Alignment of the gene Family HBG002243 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
B1H2S0_XENTR B1H2S0_XENTR ------------------------------------------------------------ PYRG2_XENLA PYRG2_XENLA ------------------------------------------------------------ PYRG2_RAT PYRG2_RAT ------------------------------------------------------------ A2AEQ7_MOUSE A2AEQ7_MOUSE ------------------------------------------------------------ PYRG2_MOUSE PYRG2_MOUSE ------------------------------------------------------------ A2AEQ8_MOUSE A2AEQ8_MOUSE ------------------------------------------------------------ A2AEQ6_MOUSE A2AEQ6_MOUSE ------------------------------MGSELLGKNSALFSSFPTFCGGGPLGCTVA B3KWM2_HUMAN B3KWM2_HUMAN ------------------------------------------------------------ PYRG2_HUMAN PYRG2_HUMAN ------------------------------------------------------------ PYRG2_BOVIN PYRG2_BOVIN ------------------------------------------------------------ PYRG2_CHICK PYRG2_CHICK ------------------------------------------------------------ Q4SYD8_TETNG Q4SYD8_TETNG NTVRTLERDRPANPQQPNSRGSQISLVLVTMNSSEGELNKLVKDGAIRIGKIQPGYGQIF PYG1A_XENLA PYG1A_XENLA ------------------------------------------------------------ PYG1B_XENLA PYG1B_XENLA ------------------------------------------------------------ B4E1E0_HUMAN B4E1E0_HUMAN ------------------------------------------------------------ PYRG1_HUMAN PYRG1_HUMAN ------------------------------------------------------------ B4DR64_HUMAN B4DR64_HUMAN ------------------------------------------------------------ B4DMB5_HUMAN B4DMB5_HUMAN ------------------------------------------------------------ B7Z9C4_HUMAN B7Z9C4_HUMAN ------------------------------------------------------------ PYRG1_CRIGR PYRG1_CRIGR ------------------------------------------------------------ A0JNE9_BOVIN A0JNE9_BOVIN ------------------------------------------------------------ Q3TPP2_MOUSE Q3TPP2_MOUSE ------------------------------------------------------------ B1AS53_MOUSE B1AS53_MOUSE ------------------------------------------------------------ PYRG1_MOUSE PYRG1_MOUSE ------------------------------------------------------------ B1WC02_RAT B1WC02_RAT ------------------------------------------------------------ A3QJW5_DANRE A3QJW5_DANRE ------------------------------------------------------------ PYRG1_DANRE PYRG1_DANRE ------------------------------------------------------------ A9JT21_DANRE A9JT21_DANRE ------------------------------------------------------------ B7ZVK1_DANRE B7ZVK1_DANRE ------------------------------------------------------------ Q6DBZ3_DANRE Q6DBZ3_DANRE ------------------------------------------------------------ B5X4W4_SALSA B5X4W4_SALSA ------------------------------------------------------------ B5X434_SALSA B5X434_SALSA ------------------------------------------------------------ Q4SGG9_TETNG Q4SGG9_TETNG ------------------------------------------------------------ Q4THD8_TETNG Q4THD8_TETNG ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

B1H2S0_XENTR B1H2S0_XENTR -------------------MKYILVTGGVISGVGKGIIASSIGTILKSCGLRVTAIKIDP PYRG2_XENLA PYRG2_XENLA -------------------MKYILVTGGVISGVGKGIIASSIGTILKSCGLRVTAIKIDP PYRG2_RAT PYRG2_RAT -------------------MKYILVTGGVISGIGKGIIASSIGTILKSCGLRVTAIKIDP A2AEQ7_MOUSE A2AEQ7_MOUSE -------------------MKYILVTGGVISGIGKGIIASSIGTILKSCGLRVTAIKIDP PYRG2_MOUSE PYRG2_MOUSE -------------------MKYILVTGGVISGIGKGIIASSIGTILKSCGLRVTAIKIDP A2AEQ8_MOUSE A2AEQ8_MOUSE -------------------MKYILVTGGVISGIGKGIIASSIGTILKSCGLRVTAIKIDP A2AEQ6_MOUSE A2AEQ6_MOUSE DGQTFMIASGYWQSPIRPPMKYILVTGGVISGIGKGIIASSIGTILKSCGLRVTAIKIDP B3KWM2_HUMAN B3KWM2_HUMAN -------------------MKYILVTGGVISGIGKGIIASSIGTILKSCGLRVTAIKIDP PYRG2_HUMAN PYRG2_HUMAN -------------------MKYILVTGGVISGIGKGIIASSIGTILKSCGLRVTAIKIDP PYRG2_BOVIN PYRG2_BOVIN -------------------MKYILVTGGVISGIGKGIIASSIGTILKSCGLRVTAIKIDP PYRG2_CHICK PYRG2_CHICK -------------------MKYILVTGGVISGIGKGIIASSIGTILKSCGLRVTAIKIDP Q4SYD8_TETNG Q4SYD8_TETNG FSFTSFPDELCHHSYSHVAMKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTAIKIDP PYG1A_XENLA PYG1A_XENLA -------------------MKYILVTGGVISGIGKGVIASSIGTILKSSNLHVTSIKIDP PYG1B_XENLA PYG1B_XENLA -------------------MKYILVTGGVISGIGKGVIASSVGTILKSSNLHVTSIKIDP B4E1E0_HUMAN B4E1E0_HUMAN ------------------------------------------------------------ PYRG1_HUMAN PYRG1_HUMAN -------------------MKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDP B4DR64_HUMAN B4DR64_HUMAN ------------------------------------------------------------ B4DMB5_HUMAN B4DMB5_HUMAN -------------------MKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDP B7Z9C4_HUMAN B7Z9C4_HUMAN ------------MPKSKSKMKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDP PYRG1_CRIGR PYRG1_CRIGR ----------------------------------------------------------DP A0JNE9_BOVIN A0JNE9_BOVIN -------------------MKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDP Q3TPP2_MOUSE Q3TPP2_MOUSE -------------------MKYILVTGGVISGIGKGVIASSVGTILKSCGLHVTSIKIDP B1AS53_MOUSE B1AS53_MOUSE -------------------MKYILVTGGVISGIGKGVIASSVGTILKSCGLHVTSIKIDP PYRG1_MOUSE PYRG1_MOUSE -------------------MKYILVTGGVISGIGKGVIASSVGTILKSCGLHVTSIKIDP B1WC02_RAT B1WC02_RAT -------------------MKYILVTGGVISGIGKGVIASSVGTILKSCGLHVTSIKIDP A3QJW5_DANRE A3QJW5_DANRE ---------------MISKMKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTAIKIDP PYRG1_DANRE PYRG1_DANRE -------------------MKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTAIKIDP A9JT21_DANRE A9JT21_DANRE -------------------MKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDP B7ZVK1_DANRE B7ZVK1_DANRE -------------------MKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDP Q6DBZ3_DANRE Q6DBZ3_DANRE -------------------MKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDP B5X4W4_SALSA B5X4W4_SALSA -------------------MKYILVTGGVISGIGKGIIASSVGTILKSCGLRVTAIKIDP B5X434_SALSA B5X434_SALSA -------------------MKYILVTGGVISGIGKGIIASSVGLILKSCGLHVTAIKIDP Q4SGG9_TETNG Q4SGG9_TETNG -------------------MKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTAIKIDP Q4THD8_TETNG Q4THD8_TETNG -------------------MKYILVTGGVISGIGKGIIASSVGTILKVCGLHVTAIKIDP MATCH CONSENSUS ???????????????????MKYILVTGGVISGIGKG?IASS?GTILKSCGL?VT?IKIDP

B1H2S0_XENTR B1H2S0_XENTR YINIDAGTFSPYEH---------------------------GEVFVLNDGGEVDLDLGNY PYRG2_XENLA PYRG2_XENLA YINIDAGTFSPYEH---------------------------GEVFVLNDGGEVDLDLGNY PYRG2_RAT PYRG2_RAT YINIDAGTFSPYEH---------------------------GEVFVLNDGGEVDLDLGNY A2AEQ7_MOUSE A2AEQ7_MOUSE YINIDAGTFSPYEH---------------------------GEVFVLNDGGEVDLDLGNY PYRG2_MOUSE PYRG2_MOUSE YINIDAGTFSPYEH---------------------------GEVFVLNDGGEVDLDLGNY A2AEQ8_MOUSE A2AEQ8_MOUSE YINIDAGTFSPYEH---------------------------GEVFVLNDGGEVDLDLGNY A2AEQ6_MOUSE A2AEQ6_MOUSE YINIDAGTFSPYEH---------------------------GEVFVLNDGGEVDLDLGNY B3KWM2_HUMAN B3KWM2_HUMAN YINIDAGTFSPYEH---------------------------GEVFVLNDGGEVDLDLGNY PYRG2_HUMAN PYRG2_HUMAN YINIDAGTFSPYEH---------------------------GEVFVLNDGGEVDLDLGNY PYRG2_BOVIN PYRG2_BOVIN YINIDAGTFSPYEH---------------------------GEVFVLNDGGEVDLDLGNY PYRG2_CHICK PYRG2_CHICK YINIDAGTFSPYEH---------------------------GEVFVLNDGGEVDLDLGNY Q4SYD8_TETNG Q4SYD8_TETNG YINIDAGTFSPYEH---------------------------GEVFVLDDGGEVDLDLGNY PYG1A_XENLA PYG1A_XENLA YINIDAGTFSPYEH---------------------------GEVFVLDDGGEVDLDLGNY PYG1B_XENLA PYG1B_XENLA YINIDAGTFSPYEH---------------------------GEVFVLDDGGEVDLDLGNY B4E1E0_HUMAN B4E1E0_HUMAN ------------------------------------------------------------ PYRG1_HUMAN PYRG1_HUMAN YINIDAGTFSPYEH---------------------------GEVFVLDDGGEVDLDLGNY B4DR64_HUMAN B4DR64_HUMAN ------------------------------------------------------------ B4DMB5_HUMAN B4DMB5_HUMAN YINIDAGTFSPYEH---------------------------GEVFVLDDGGEVDLDLGNY B7Z9C4_HUMAN B7Z9C4_HUMAN YINIDAGTFSPYEH---------------------------GEVFVLDDGGEVDLDLGNY PYRG1_CRIGR PYRG1_CRIGR YINIDAGTFSPYEH---------------------------GEVFVLDDGGEVDLDLGNY A0JNE9_BOVIN A0JNE9_BOVIN YINIDAGTFSPYEH---------------------------GEVFVLDDGGEVDLDLGNY Q3TPP2_MOUSE Q3TPP2_MOUSE YINIDAGTFSPYEH---------------------------GEVFVLDDGGEVDLDLGNY B1AS53_MOUSE B1AS53_MOUSE YINIDAGTFSPYEH---------------------------GEVFVLDDGGEVDLDLGNY PYRG1_MOUSE PYRG1_MOUSE YINIDAGTFSPYEH---------------------------GEVFVLDDGGEVDLDLGNY B1WC02_RAT B1WC02_RAT YINIDAGTFSPYEH---------------------------GEVFVLDDGGEVDLDLGNY A3QJW5_DANRE A3QJW5_DANRE YINIDAGTFSPYEH---------------------------GEVFVLDDGGEVDLDLGNY PYRG1_DANRE PYRG1_DANRE YINIDAGTFSPYEH---------------------------GEVFVLDDGGEVDLDLGNY A9JT21_DANRE A9JT21_DANRE YINIDAGTFSPYEH---------------------------GEVFVLDDGGEVDLDLGNY B7ZVK1_DANRE B7ZVK1_DANRE YINIDAGTFSPYEH---------------------------GEVFVLDDGGEVDLDLGNY Q6DBZ3_DANRE Q6DBZ3_DANRE YINIDAGTFSPYEH---------------------------GEVFVLDDGGEVDLDLGNY B5X4W4_SALSA B5X4W4_SALSA YINIDAGTFSPYEH---------------------------GEVFVLDDGGEVDLDLGNY B5X434_SALSA B5X434_SALSA YINIDAGTFSPYEH---------------------------GEVFVLDDGGEVDLDLGNY Q4SGG9_TETNG Q4SGG9_TETNG YINIDAGTFSPYEHGRSEGVDEPVCVCVCVCVCVMVASCHAGEVFVLDDGGEVDLDLGNY Q4THD8_TETNG Q4THD8_TETNG YINIDAGTFSPYEH---------------------------GEVFVLDDGGEVDLDLGNY MATCH CONSENSUS YINIDAGTFSPYEH???????????????????????????GEVFVL?DGGEVDLDLGNY

B1H2S0_XENTR B1H2S0_XENTR ERFLDINLYKDNNITTGKIYQQVINRERRGDYLGKTVQVVPHITDAIQEWVLNQAKVPVD PYRG2_XENLA PYRG2_XENLA ERFLDINLYKDNNITTGKIYQQVINRERRGDYLGKTVQVVPHITDAIQEWVLNQAKVPVD PYRG2_RAT PYRG2_RAT ERFLDINLYKDNNITTGKIYQHVINKERRGDYLGKTVQVVPHITDAIQDWVMNQAKVSVD A2AEQ7_MOUSE A2AEQ7_MOUSE ERFLDINLYKDNNITTGKIYQHVINKERRGDYLGKTVQVVPHITDAIQEWVMNQAKVSVD PYRG2_MOUSE PYRG2_MOUSE ERFLDINLYKDNNITTGKIYQHVINKERRGDYLGKTVQVVPHITDAIQEWVMNQAKVSVD A2AEQ8_MOUSE A2AEQ8_MOUSE ERFLDINLYKDNNITTGKIYQHVINKERRGDYLGKTVQVVPHITDAIQEWVMNQAKVSVD A2AEQ6_MOUSE A2AEQ6_MOUSE ERFLDINLYKDNNITTGKIYQHVINKERRGDYLGKTVQVVPHITDAIQEWVMNQAKVSVD B3KWM2_HUMAN B3KWM2_HUMAN ERFLDINLYKDNNITTGKIYQHVINKERRGDYLGKTVQVVPHITDAVQEWVMNQAKVPVD PYRG2_HUMAN PYRG2_HUMAN ERFLDINLYKDNNITTGKIYQHVINKERRGDYLGKTVQVVPHITDAVQEWVMNQAKVPVD PYRG2_BOVIN PYRG2_BOVIN ERFLDINLYKDNNITTGKIYQHVINKERRGDYLGKTVQVVPHITDAVQEWVMNQAMVPVD PYRG2_CHICK PYRG2_CHICK ERFLDINLYKDNNITTGKIYQHVINKERHGDYLGKTVQVVPHITDAVQEWVMNQAKVPVD Q4SYD8_TETNG Q4SYD8_TETNG ERFLDIRLTKNNNLTTGKIYQSVINKERKGDYLGKTVQVVPHITDAIQEWVMKQARVSVD PYG1A_XENLA PYG1A_XENLA ERFLDIRLTKDNNLTTGKIYQSVINKERKGDYLGKTVQVVPHITDAIQEWVMRQALIPVD PYG1B_XENLA PYG1B_XENLA ERFLDIRLTKDNNLTTGKIYQSVINKERKGDYLGKTVQVVPHITEAIQEWVMRQALIPVD B4E1E0_HUMAN B4E1E0_HUMAN ------------------------------------------------------------ PYRG1_HUMAN PYRG1_HUMAN ERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDAIQEWVMRQALIPVD B4DR64_HUMAN B4DR64_HUMAN ------------------------------------------------------------ B4DMB5_HUMAN B4DMB5_HUMAN ERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQAVPHITDAIQEWVMRQALIPVD B7Z9C4_HUMAN B7Z9C4_HUMAN ERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDAIQEWVMRQALIPVD PYRG1_CRIGR PYRG1_CRIGR ERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVHVVPHITDAIQRWVMRQALIPVD A0JNE9_BOVIN A0JNE9_BOVIN ERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDAIQEWVMRQALIPVD Q3TPP2_MOUSE Q3TPP2_MOUSE ERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDAIQEWVMRQALIPVD B1AS53_MOUSE B1AS53_MOUSE ERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDAIQEWVMRQALIPVD PYRG1_MOUSE PYRG1_MOUSE ERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDAIQEWVMRQALIPVD B1WC02_RAT B1WC02_RAT ERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDAIQEWVMRQALIPVD A3QJW5_DANRE A3QJW5_DANRE ERFLDIRLTKDNNLTTGKIYQSVINKERRGDYLGKTVQVVPHITDAIQEWVMRQAKIPVD PYRG1_DANRE PYRG1_DANRE ERFLDIRLTKDNNLTTGKIYQSVINKERRGDYLGKTVQVVPHITDAIQEWVMRQAKIPVD A9JT21_DANRE A9JT21_DANRE ERFLDIRLTRDNNLTTGKIYQSVINKERRGDYLGKTVQVVPHITDAIQEWVMRQAKVSVD B7ZVK1_DANRE B7ZVK1_DANRE ERFLDIRLTRDNNLTTGKIYQSVINKERRGDYLGKTVQVVPHITDAIQEWVMRQAKVSVD Q6DBZ3_DANRE Q6DBZ3_DANRE ERFLDIRLTRDNNLTTGKIYQSVINKERRGDYLGKTVQVVPHITDAIQEWVMRQAKVSVD B5X4W4_SALSA B5X4W4_SALSA ERFLDIRLTKDNNLTTGKIYQSVINKERKGDYLGKTVQVVPHITDAIQEWVMRQARVPVD B5X434_SALSA B5X434_SALSA ERFLDIRLTRDNNLTTGKIYQSVINKERRGDYLGKTVQVVPHITDAIQEWVVKQAKISVD Q4SGG9_TETNG Q4SGG9_TETNG ERFLDIRLTRDNNLTTGKIYQSVINKERRGDYLGKTVQVVPHITDAIQEWVEKQATVPVD Q4THD8_TETNG Q4THD8_TETNG ERFLDIRLTRDNNLTTGKIYQSVINKERRGDYLGKTVQVVPHMTDAIQEWVEKQVTVPVD MATCH CONSENSUS ERFLDI?L??DNN?TTGKIYQ?VINKER?GDYLGKTVQVVPHITDAIQEWV??QA???VD

B1H2S0_XENTR B1H2S0_XENTR SDQKEPQICVIELGGTIGDIEGMPFIEAFRQFQFKAKRENFCNIHVSLVPQPSATGEQKT PYRG2_XENLA PYRG2_XENLA RDQKEPQICVIELGGTIGDIEGMPFIEAFRQFQFKAKRENFCNIHVSLVPQPSATGEQKT PYRG2_RAT PYRG2_RAT GNKEDPQICVIELGGTIGDIEGMAFVEAFRQFQFKAKRENFYNIHVSLVPQPSATGEQKT A2AEQ7_MOUSE A2AEQ7_MOUSE GNKEDPQICVIELGGTIGDIEGMAFVEAFRQFQFKAKKENFYNIHVSLVPQPSATGEQKT PYRG2_MOUSE PYRG2_MOUSE GNKEDPQICVIELGGTIGDIEGMAFVEAFRQFQFKAKKENFYNIHVSLVPQPSATGEQKT A2AEQ8_MOUSE A2AEQ8_MOUSE GNKEDPQICVIELGGTIGDIEGMAFVEAFRQFQFKAKKENFYNIHVSLVPQPSATGEQKT A2AEQ6_MOUSE A2AEQ6_MOUSE GNKEDPQICVIELGGTIGDIEGMAFVEAFRQFQFKAKKENFYNIHVSLVPQPSATGEQKT B3KWM2_HUMAN B3KWM2_HUMAN GNKEEPQICVIELGGTIGDIEGMPFVEAFRQFQFKAKRENFCNIHVSLVPQLSATGEQKT PYRG2_HUMAN PYRG2_HUMAN GNKEEPQICVIELGGTIGDIEGMPFVEAFRQFQFKAKRENFCNIHVSLVPQLSATGEQKT PYRG2_BOVIN PYRG2_BOVIN GHKEEPQICVIELGGTIGDIEGMPFVEAFRQFQFKAKRENFCNIHVSLVPQPSATGEQKT PYRG2_CHICK PYRG2_CHICK DDRKEPQICVIELGGTIGDIEGMPFVEAFRQFQFKAKRENFCNIHVSLVPQPNATGEQKT Q4SYD8_TETNG Q4SYD8_TETNG DDDIEPEVCVIE------------------------------------------------ PYG1A_XENLA PYG1A_XENLA EDGIEPEVCVIELGGTVGDIESMPFVEAFRQFQFKVRRENFCNIHVSLVPQPSATGEQKT PYG1B_XENLA PYG1B_XENLA EDGIEPEVCVIELGGTVGDIESMPFVEAFRQFQFKARRENFCNIHVSLVPQPSATGEQKT B4E1E0_HUMAN B4E1E0_HUMAN ----------------------MPFIEAFRQFQFKVKRENFCNIHVSLVPQPSSTGEQKT PYRG1_HUMAN PYRG1_HUMAN EDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPSSTGEQKT B4DR64_HUMAN B4DR64_HUMAN ------------------------------------------------------------ B4DMB5_HUMAN B4DMB5_HUMAN EDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPSSTGEQKT B7Z9C4_HUMAN B7Z9C4_HUMAN EDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPSSTGEQKT PYRG1_CRIGR PYRG1_CRIGR EDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPSSTGEQKT A0JNE9_BOVIN A0JNE9_BOVIN EDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPSSTGEQKT Q3TPP2_MOUSE Q3TPP2_MOUSE EDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPSSTGEQKT B1AS53_MOUSE B1AS53_MOUSE EDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPSSTGEQKT PYRG1_MOUSE PYRG1_MOUSE EDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPSSTGEQKT B1WC02_RAT B1WC02_RAT EDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKKENFCNIHVSLVPQPSSTGEQKT A3QJW5_DANRE A3QJW5_DANRE DDDVEPQVCVIELGGTVGDIESMPFVEAFRQFQFKVKRENFCNIHVSLVPQPSATGEQKT PYRG1_DANRE PYRG1_DANRE DDDVEPQVCVIELGGTVGDIESMPFVEAFRQFQFKVKRENFCNIHVSLVPQPSATGEQKT A9JT21_DANRE A9JT21_DANRE DDGIEPEVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPNSTGEQKT B7ZVK1_DANRE B7ZVK1_DANRE DDGIEPEVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPNSTGEQKT Q6DBZ3_DANRE Q6DBZ3_DANRE DDGIEPEVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPNSTGEQKT B5X4W4_SALSA B5X4W4_SALSA DDGVEPQICVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPSATGEQKT B5X434_SALSA B5X434_SALSA DDGVEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRDNFCNIHVSLVPQPSATGEQKT Q4SGG9_TETNG Q4SGG9_TETNG DDGVEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVRRENFCNIHVSLIPQPGTTGEQKT Q4THD8_TETNG Q4THD8_TETNG DDGVEPQVCVIELGGTVGDIESMPFI---------------------------------- MATCH CONSENSUS ?????P??CVIELGGT?GDIE?M?F?EAFRQFQFK?K?ENF?NIHVSLVPQP??TGEQKT

B1H2S0_XENTR B1H2S0_XENTR KPTQNSVRALRGLGLSPDLIVCRSAKPIEMAVKQKISMFCHVEPEQVIFVHDVSSTYRVP PYRG2_XENLA PYRG2_XENLA KPTQNSVRALRGLGLSPDLIVCRSAKPIEMAVKQKISMFCHVEPEQVIFVHDVSSTYRVP PYRG2_RAT PYRG2_RAT KPTQNSVRALRGLGLSPDLIVCRSSTPIEMAVKEKISMFCHVNPEQVICIHDVSSIYRVP A2AEQ7_MOUSE A2AEQ7_MOUSE KPTQNSVRALRGLGLSPDLIVCRSSTPIEMAVKEKISMFCHVNPEQVICIHDVSSIYRVP PYRG2_MOUSE PYRG2_MOUSE KPTQNSVRALRGLGLSPDLIVCRSSTPIEMAVKEKISMFCHVNPEQVICIHDVSSIYRVP A2AEQ8_MOUSE A2AEQ8_MOUSE KPTQNSVRALRGLGLSPDLIVCRSSTPIEMAVKEKISMFCHVNPEQVICIHDVSSIYRVP A2AEQ6_MOUSE A2AEQ6_MOUSE KPTQNSVRALRGLGLSPDLIVCRSSTPIEMAVKEKISMFCHVNPEQVICIHDVSSIYRVP B3KWM2_HUMAN B3KWM2_HUMAN KPTQNSVRALRGLGLSPDLIVCRSSTPIEMAVKEKISMFCHVNPEQVICIHDVSSTYRVP PYRG2_HUMAN PYRG2_HUMAN KPTQNSVRALRGLGLSPDLIVCRSSTPIEMAVKEKISMFCHVNPEQVICIHDVSSTYRVP PYRG2_BOVIN PYRG2_BOVIN KPTQNSVRALRGLGLSPDLIVCRSSTPIEMAVKEKISMFCHVNPEQVICIHDVSSTYRVP PYRG2_CHICK PYRG2_CHICK KPTQNSVRALRGLGLSPDLIVCRSAKPIEMAVKEKISMFCHVEPEQVIFIHDVSSTYRVP Q4SYD8_TETNG Q4SYD8_TETNG ----------------------------------------------VICVQDVSSIYRVP PYG1A_XENLA PYG1A_XENLA KPTQNSVRELRGLGLSPDLVVCRCSTPLDTSVKEKISMFCHVEPQQVICVHDVSSIYRVP PYG1B_XENLA PYG1B_XENLA KPTQNSVRELRGLGLSPDLVVCRCSTPLDTSVKEKISMFCHVEPQQVICVHDVSSIYRVP B4E1E0_HUMAN B4E1E0_HUMAN KPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQVICVHDVSSIYRVP PYRG1_HUMAN PYRG1_HUMAN KPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQVICVHDVSSIYRVP B4DR64_HUMAN B4DR64_HUMAN -------------------------------------MFCHVEPEQVICVHDVSSIYRVP B4DMB5_HUMAN B4DMB5_HUMAN KPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQVICVHDVSSIYRVP B7Z9C4_HUMAN B7Z9C4_HUMAN KPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQVICVHDVSSIYRVP PYRG1_CRIGR PYRG1_CRIGR KPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQVICVHDVSSIYRVP A0JNE9_BOVIN A0JNE9_BOVIN KPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQVICVHDVSSIYRVP Q3TPP2_MOUSE Q3TPP2_MOUSE KPTQNSVRELRGLGLSPDLEVCRCSNPLDTSA---------------------------- B1AS53_MOUSE B1AS53_MOUSE KPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQVICVHDVSSIYRVP PYRG1_MOUSE PYRG1_MOUSE KPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQVICVHDVSSIYRVP B1WC02_RAT B1WC02_RAT KPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQVICVHDVSSIYRVP A3QJW5_DANRE A3QJW5_DANRE KPTQNSVRELRGLGLSPDLIMCRCSTPLDNSVKEKISMFCHVEPEQVICVHDVSSIYRVP PYRG1_DANRE PYRG1_DANRE KPTQNSVRELRGLGLSPDLIMCRCSTPLDNSVKEKISMFCHVEPEQVICVHDVSSIYRVP A9JT21_DANRE A9JT21_DANRE KPTQNSVRELRGLGLSPDLIVCRCSTPLDTAVKEKISMFCHVEPEQVICIHDVSSIYRVP B7ZVK1_DANRE B7ZVK1_DANRE KPTQNSVRELRGLGLSPDLIVCRCSTPLDTAVKEKISMFCHVEPEQVICIHDVSSIYRVP Q6DBZ3_DANRE Q6DBZ3_DANRE KPTQNSVRELRGLGLSPDLIVCRCSTPLDTAVKEKISMFCHVEPEQVICIHDVSSIYRVP B5X4W4_SALSA B5X4W4_SALSA KPTQNSVRELRGLGLSPDLIMCRCSTPLENSVKEKISMFCHVEPEQVICVADVSSIYRVP B5X434_SALSA B5X434_SALSA KPTQNSVRELRGLGLSPDLIMCRCATPLENAVKEKISMFCHVEPTQVICVADVSSIYRVP Q4SGG9_TETNG Q4SGG9_TETNG KPTQNSVRELRGLGLSPDLIMCRCTTALENSVKEKISMFCHVEPEQVICVHDVSSIYRVP Q4THD8_TETNG Q4THD8_TETNG ------------------------------------------------------------ MATCH CONSENSUS KPTQNSVR?LRGLGLSPDL??CR???P????VKEKISMFCHV?PEQVIC?HDVSS?YRVP

B1H2S0_XENTR B1H2S0_XENTR ILLQEQGIIKYFKQRLSIPIDDQPSTLLFKWKRMADRYERLLKTCSIALVGKYTKLSDCY PYRG2_XENLA PYRG2_XENLA ILLQEQGIIKYFKQRLSIPIEDQPSTQLFKWKRMADRYERLLKTCSIALVGKYTKLSDCY PYRG2_RAT PYRG2_RAT LLLEEQGVVKYFQERLDLPINDCSNNLLFKWKTMADRYERLQKICSIALVGKYTKLRDCY A2AEQ7_MOUSE A2AEQ7_MOUSE LLLEEQGVVKYFQERLGLPINDCSSNLLFKWKAMADRYERLQKICSIALVGKYTKLRDCY PYRG2_MOUSE PYRG2_MOUSE LLLEEQGVVKYFQERLGLPINDCSSNLLFKWKAMADRYERLQKICSIALVGKYTKLRDCY A2AEQ8_MOUSE A2AEQ8_MOUSE LLLEEQGVVKYFQERLGLPINDCSSNLLFKWKAMADRYERLQKICSIALVGKYTKLRDCY A2AEQ6_MOUSE A2AEQ6_MOUSE LLLEEQGVVKYFQERLGLPINDCSSNLLFKWKAMADRYERLQKICSIALVGKYTKLRDCY B3KWM2_HUMAN B3KWM2_HUMAN VLLEEQSIVKYFKERLHLPIGDSASNLLFKWRNMADRYERLQKICSIALVGKYTKLRDCY PYRG2_HUMAN PYRG2_HUMAN VLLEEQSIVKYFKERLHLPIGDSASNLLFKWRNMADRYERLQKICSIALVGKYTKLRDCY PYRG2_BOVIN PYRG2_BOVIN VLLEEQGIIKYFKERLDLPIGDSASSLLSKWRNMADRYERLQKTCSIALVGKYTKLRDCY PYRG2_CHICK PYRG2_CHICK ILLEEQGIIKYFKQRLNLPIDDQPSDLLMKWKKMADRYERLLKVCSIALVGKYTKLSDCY Q4SYD8_TETNG Q4SYD8_TETNG LLLEEQGVVNYFCNRLNMSVKMSPRKMLTKWKEMADRSDRLLEHVTIALVGKYTKLADSY PYG1A_XENLA PYG1A_XENLA LLLEEQGVVDYFRQRLDLPIGRQPRRLLMKWKEMADRYERLLESCSIALVGKYTKFSDSY PYG1B_XENLA PYG1B_XENLA LLLEEQGVVDYFRQRLDLPIGRQPRRLLMKWKEMADRYERLLESCSIALVGKYTKFSDSY B4E1E0_HUMAN B4E1E0_HUMAN LLLEEQGVVDYFLRRLDLPIERQPRKMLMKWKEMADRYDRLLETCSIALVGKYTKFSDSY PYRG1_HUMAN PYRG1_HUMAN LLLEEQGVVDYFLRRLDLPIERQPRKMLMKWKEMADRYDRLLETCSIALVGKYTKFSDSY B4DR64_HUMAN B4DR64_HUMAN LLLEEQGVVDYFLRRLDLPIERQPRKMLMKWKEMADRYDRLLETCSIALVGKYTKFSDSY B4DMB5_HUMAN B4DMB5_HUMAN LLLEEQGVVDYFLRRLDLPIERQPRKMLMKWKEMADRYDRLLETCSIALVGKYTKFSDSY B7Z9C4_HUMAN B7Z9C4_HUMAN LLLEEQGVVDYFLRRLDLPIERQPRKMLMKWKEMADRFA--------------------- PYRG1_CRIGR PYRG1_CRIGR LLLEEQGVVDYFLRSLELPIERQSRKMLMKWKEMADRYDRLLETCSIALVGKYTKLSDSY A0JNE9_BOVIN A0JNE9_BOVIN LLLEEQGVVDYFLRRLDLPIERQPRKMLMKWKEMADRYDRLLETCSIALVGKYTKFSDSY Q3TPP2_MOUSE Q3TPP2_MOUSE ------------------------------------------------------------ B1AS53_MOUSE B1AS53_MOUSE LLLEEQGVVDYFLRRLDLPIERQSRKMLMKWKEMADRYDRLLETCSIALVGKYTKFSDSY PYRG1_MOUSE PYRG1_MOUSE LLLEEQGVVDYFLRRLDLPIERQSRKMLMKWKEMADRYDRLLETCSIALVGKYTKFSDSY B1WC02_RAT B1WC02_RAT LLLEEQGVVDYFLRRLDLPVERQSRKMLMKWKEMADRYDRLLETCSIALVGKYTKFSDSY A3QJW5_DANRE A3QJW5_DANRE LLLEDQGVVGYFCRRLNLPIENRPRKMLAKWKEMSDRSDRLLEQCSIALVGKYTKFSDSY PYRG1_DANRE PYRG1_DANRE LLLEDQGVVGYFCRRLNLPIENRPRKMLAKWKEMSDRSDRLLEQCSIALVGKYTKFSDSY A9JT21_DANRE A9JT21_DANRE LLLEDQGMVHYFCRRLDLPIQMRPRQMLRKWKEMSDRSDRLLEQTSIALVGKYTKLSDSY B7ZVK1_DANRE B7ZVK1_DANRE LLLEDQGMVHYFCRRLDLPIQMRPRQMLRKWKEMSDRSDRLLEQTSIALVGKYTKLSDSY Q6DBZ3_DANRE Q6DBZ3_DANRE LLLEDQGMVHYFCRRLDLPIQMRPRQMLRKWKEMSDRSDRLLEQTSIALVGKYTKLSDSY B5X4W4_SALSA B5X4W4_SALSA LLLENQGVVGYFCQRLDLPIETRPRKMLTKWKEMSDRSDRLLEQCSIALVGKYTKFTDSY B5X434_SALSA B5X434_SALSA LLLEDQGVVGYICQRLDLPIEMRARKMLTKWKEMSDRSDRLLEHVSVALVGKYTKFSDSY Q4SGG9_TETNG Q4SGG9_TETNG LLLESQGVVSYLSRRLNMPIETRPRKMLTKWKEMSDRSDRLLEQCSIALVGKYTKFSDSY Q4THD8_TETNG Q4THD8_TETNG ------------------------------------------------------------ MATCH CONSENSUS ?LLE?QG?V?YF??RL?LPI???????L?KWK?M?DR??RL????SIALVGKYTK??D?Y

B1H2S0_XENTR B1H2S0_XENTR TSVFKALEHSALAINHKLNLMYIDSADLEPSMKAEDPVKYHKAWEELCKAEGILVPGGFG PYRG2_XENLA PYRG2_XENLA TSVFKALEHSALAINHKLNLMYIDSADLEPSMKAQDPVKYHKAWEELCKAEGILVPGGFG PYRG2_RAT PYRG2_RAT ASVFKALEHSALAINHKLNLMYIDSIDLEPVTKAEDPVKFHEAWQKLCLADGILVPGGFG A2AEQ7_MOUSE A2AEQ7_MOUSE ASVFKALEHSALAINHKLNLMYIDSIDLEPVTKAEDPVKFHEAWQKLCLADGILVPGGFG PYRG2_MOUSE PYRG2_MOUSE ASVFKALEHSALAINHKLNLMYIDSIDLEPVTKAEDPVKFHEAWQKLCLADGILVPGGFG A2AEQ8_MOUSE A2AEQ8_MOUSE ASVFKALEHSALAINHKLNLMYIDSIDLEPVTKAEDPVKFHEAWQKLCLADGILVPGGFG A2AEQ6_MOUSE A2AEQ6_MOUSE ASVFKALEHSALAINHKLNLMYIDSIDLEPVTKAEDPVKFHEAWQKLCLADGILVPGGFG B3KWM2_HUMAN B3KWM2_HUMAN ASVFKALEHSALAINHKLNLMYIDSIDLEKITETEDPVKFHEAWQKLCKADGILVPGGFG PYRG2_HUMAN PYRG2_HUMAN ASVFKALEHSALAINHKLNLMYIDSIDLEKITETEDPVKFHEAWQKLCKADGILVPGGFG PYRG2_BOVIN PYRG2_BOVIN ASVFKALEHSALAINHKLNLMYIDSIDLEQTTEVEDPVKFHEAWQKLCKADGVLVPGGFG PYRG2_CHICK PYRG2_CHICK ASVFKALEHSALAINHKLDLMYIDSTELERSTEVENSVKYHQAWHKLCKADGILVPGGFG Q4SYD8_TETNG Q4SYD8_TETNG TSVIKALEHSALAINHKLEVKYIDSEDLEPTTLGVEPVKYHEAWQKLCSSQGVLVPGGFG PYG1A_XENLA PYG1A_XENLA ASVIKALEHSALAINHRLEIKYIDSADLEQETLQEEPVRYHEAWQKLCSSEGILVPGGFG PYG1B_XENLA PYG1B_XENLA ASVIKALEHSALAINHRLEIKYIDSADLEQETLQEEPVRYHEAWQKLCSSDGILVPGGFG B4E1E0_HUMAN B4E1E0_HUMAN ASVIKALEHSALAINHKLEIKYIDSADLEPITSQEEPVRYHEAWQKLCSAHGVLVPGGFG PYRG1_HUMAN PYRG1_HUMAN ASVIKALEHSALAINHKLEIKYIDSADLEPITSQEEPVRYHEAWQKLCSAHGVLVPGGFG B4DR64_HUMAN B4DR64_HUMAN ASVIKALEHSALAINHKLEIKYIDSADLEPITSQEEPVRYHEAWQKLCSAHGVLVPGGFG B4DMB5_HUMAN B4DMB5_HUMAN ASVIKALEHSALAINHKLEIKYIDSADLEPITSQEEPVRYHEAWQKLCSAHGVLVPGGFG B7Z9C4_HUMAN B7Z9C4_HUMAN -----------------------------------------------CNEE--------- PYRG1_CRIGR PYRG1_CRIGR ASVIKALEHSALAINHKLEIKYIDSTDLEPSTLQEEPVRYHEAWQKLCSAHGVLVPGGFG A0JNE9_BOVIN A0JNE9_BOVIN ASVIKALEHSALAINHKLEIKYIDSTDLEPSTLQEDPVRYHEAWQKLCSAHGVLVPGGFG Q3TPP2_MOUSE Q3TPP2_MOUSE ------------------------------------------------------------ B1AS53_MOUSE B1AS53_MOUSE ASVIKALEHSALAINHKLEIKYIDSTDLEPSTLQEEPVRYHEAWQKLCSAHGVLVPGGFG PYRG1_MOUSE PYRG1_MOUSE ASVIKALEHSALAINHKLEIKYIDSTDLEPSTLQEEPVRYHEAWQKLCSAHGVLVPGGFG B1WC02_RAT B1WC02_RAT ASVIKALEHSALAINHKLEIKYIDSTDLEPSTLQEEPVRYHEAWQKLCSAHGVLVPGGFG A3QJW5_DANRE A3QJW5_DANRE ASVIKALEHSALAISHKLEVKYVDSADLEPSMLQEEPVKYHEAWQKLCSSDGILVPGGFG PYRG1_DANRE PYRG1_DANRE ASVIKALEHSALAISHKLEVKYVDSADLEPSMLQEEPVKYHEAWQKLCSSDGILVPGGFG A9JT21_DANRE A9JT21_DANRE ASVIKALEHSALAINYKLEVKYIDSAYLEPAALQDEPVKYHEAWQKLCSADGVLVPGGFG B7ZVK1_DANRE B7ZVK1_DANRE ASVIKALEHSALAINYKLEVKYIDSAYLEPAALQDEPVKYHEAWQKLCSADGVLVPGGFG Q6DBZ3_DANRE Q6DBZ3_DANRE ASVIKALEHSALAINYKLEVKYIDSAYLEPAALQDEPVKYHEAWQKLCSADGVLVPGGFG B5X4W4_SALSA B5X4W4_SALSA ASVIKALEHSALAICHKLDIKYIDSADLEPNTLKEEPVKYHEAWQKLCSADGILVPGGFG B5X434_SALSA B5X434_SALSA ASVIKALEHSALAINHKLEIKFIDSADLEPNTLQEEPVKYHEAWQKLCSADGVLVPGGFG Q4SGG9_TETNG Q4SGG9_TETNG ASVIKALEHSALAISHKLEVKYIDSACLEPSTLQEEPVKYHEAWQKLCSSDGVLVPGGFG Q4THD8_TETNG Q4THD8_TETNG ------------------------------------------------------------ MATCH CONSENSUS ASV?KALEHSALAI?HKL???YIDS??LE???????PV??HEAWQKLC???G?LVPGGFG

B1H2S0_XENTR B1H2S0_XENTR LRGTEGKIQAITWARERKIPFL----------------------GICLGMQLAVVEFARN PYRG2_XENLA PYRG2_XENLA LRGTEGKIQAITWARERKIPFL----------------------GICLGMQLAVVEFARN PYRG2_RAT PYRG2_RAT IRGTLGKLQAISWARTKKIPFL----------------------GICLGMQLAVIEFARN A2AEQ7_MOUSE A2AEQ7_MOUSE IRGTLGKLQAISWARTKKIPFL----------------------GICLGMQLAVIEFARN PYRG2_MOUSE PYRG2_MOUSE IRGTLGKLQAISWARTKKIPFL----------------------GICLGMQLAVIEFARN A2AEQ8_MOUSE A2AEQ8_MOUSE IRGTLGKLQAISWARTKKIPFL----------------------GICLGMQLAVIEFARN A2AEQ6_MOUSE A2AEQ6_MOUSE IRGTLGKLQAISWARTKKIPFL----------------------GICLGMQLAVIEFARN B3KWM2_HUMAN B3KWM2_HUMAN IRGTLGKLQAISWARTKKIPFL----------------------GVCLGMQLAVIEFARN PYRG2_HUMAN PYRG2_HUMAN IRGTLGKLQAISWARTKKIPFL----------------------GVCLGMQLAVIEFARN PYRG2_BOVIN PYRG2_BOVIN IRGTLGKLQAISWARSRKIPFL----------------------GVCLGMQLAVIEFARN PYRG2_CHICK PYRG2_CHICK IRGTEGKLQAISWARTKKKPFL----------------------GVCLGMQLAVVEFARN Q4SYD8_TETNG Q4SYD8_TETNG ARGTEGKMLAINWARKQNKPYL----------------------GVCLGMQLAVCEFARN PYG1A_XENLA PYG1A_XENLA VRGTEGKIQAIAWARKQKKPFL----------------------GVCLGMQLAVVEFARD PYG1B_XENLA PYG1B_XENLA VRGTEGKIQAIAWARKQKKPFL----------------------GVCLGMQLAVVEFARD B4E1E0_HUMAN B4E1E0_HUMAN VRGTEGKIQAIAWARNQKKPFL----------------------GVCLGMQLAVVEFSRN PYRG1_HUMAN PYRG1_HUMAN VRGTEGKIQAIAWARNQKKPFL----------------------GVCLGMQLAVVEFSRN B4DR64_HUMAN B4DR64_HUMAN VRGTEGKIQAIAWARNQKKPFL----------------------GVCLGMQLAVVEFSRN B4DMB5_HUMAN B4DMB5_HUMAN VRGTEGKIQAIAWARNQKKPFL----------------------GVCLGMQLAVVEFSRN B7Z9C4_HUMAN B7Z9C4_HUMAN ---------------------L----------------------GVLASFTLL------- PYRG1_CRIGR PYRG1_CRIGR VRGTEGKIQAIAWARKQKKPFL----------------------GVCLGMQLAVVEFSRN A0JNE9_BOVIN A0JNE9_BOVIN VRGTEGKIQAISWARKQKKPFL----------------------GVCLGMQLAVVEFSRN Q3TPP2_MOUSE Q3TPP2_MOUSE ------------------------------------------------------------ B1AS53_MOUSE B1AS53_MOUSE VRGTEGKIQAIAWARKQKKPFL----------------------GVCLGMQLAVVEFSRN PYRG1_MOUSE PYRG1_MOUSE VRGTEGKIQAIAWARKQKKPFL----------------------GVCLGMQLAVVEFSRN B1WC02_RAT B1WC02_RAT VRGTEGKIQAIAWARKQKKPFL----------------------GVCLGMQLAVVEFSRN A3QJW5_DANRE A3QJW5_DANRE VRGTEGKIQAINWARKQKKPFL----------------------GVCLGMQLAVCEFARN PYRG1_DANRE PYRG1_DANRE VRGTEGKIQAINWARKQKKPFL----------------------GVCLGMQLAVCEFARN A9JT21_DANRE A9JT21_DANRE VRGTEGKIQAINWARKQKKPFL----------------------GVCLGMQLAVCEFARN B7ZVK1_DANRE B7ZVK1_DANRE VRGTEGKIQAINWARKQKKPFL----------------------GVCLGMQLAVCEFARN Q6DBZ3_DANRE Q6DBZ3_DANRE VRGTEGKIQAINWARKQKKPFL----------------------GVCLGMQLAVCEFARN B5X4W4_SALSA B5X4W4_SALSA VRGTEGKIHAINWARKQKKPFL----------------------GVCLGMQLAVCEFARN B5X434_SALSA B5X434_SALSA VRGTEGKIQAISWARKKKKPFL----------------------GICLGMQLAVCEFARN Q4SGG9_TETNG Q4SGG9_TETNG VRGTEGKIHAIGWARKQRKPFLGENVRLSEGVAPVTVSKTFVCAGVCLGMQLAVCEFARN Q4THD8_TETNG Q4THD8_TETNG ------------------------------------------------------------ MATCH CONSENSUS ?RGT?GK?QAI?WAR??K?PFL??????????????????????G?CLGMQLAV?EF?RN

B1H2S0_XENTR B1H2S0_XENTR ILKMT----------------------------DANSTEFDPNTNNPVVIDMPEHHPGDM PYRG2_XENLA PYRG2_XENLA ILKMT----------------------------DANSTEFDPNTKNPAVIDMPEHHPGDM PYRG2_RAT PYRG2_RAT CLNLK----------------------------DANSTEFDPNTPVPLVIDMPEHNPGDL A2AEQ7_MOUSE A2AEQ7_MOUSE CLNLK----------------------------DANSTEFEPNTPVPLVIDMPEHNPGDL PYRG2_MOUSE PYRG2_MOUSE CLNLK----------------------------DANSTEFEPNTPVPLVIDMPEHNPGDL A2AEQ8_MOUSE A2AEQ8_MOUSE CLNLK----------------------------DANSTEFEPNTPVPLVIDMPEHNPGDL A2AEQ6_MOUSE A2AEQ6_MOUSE CLNLK----------------------------DANSTEFEPNTPVPLVIDMPEHNPGDL B3KWM2_HUMAN B3KWM2_HUMAN CLNLK----------------------------DADSTEFRPNAPVPLVIDMPEHNPGNL PYRG2_HUMAN PYRG2_HUMAN CLNLK----------------------------DADSTEFRPNAPVPLVIDMPEHNPGNL PYRG2_BOVIN PYRG2_BOVIN CLNLK----------------------------DADSTEFEPNARVPVVIDMPEHNPGNL PYRG2_CHICK PYRG2_CHICK CLNWK----------------------------DANSTEFDPDTKSPVVIDMPEHNPGDM Q4SYD8_TETNG Q4SYD8_TETNG VLGWK----------------------------DANSTEFNPESKYPVVIEMPEHNPGQM PYG1A_XENLA PYG1A_XENLA VLGWT----------------------------DANSTEFNPKTSHPVVIDMPEHNPGQM PYG1B_XENLA PYG1B_XENLA VLDWK----------------------------DANSTEFNPKTSHPVVIDMPEHNPGQM B4E1E0_HUMAN B4E1E0_HUMAN VLGWQ----------------------------DANSTEFDPTTSHPVVVDMPEHNPGQM PYRG1_HUMAN PYRG1_HUMAN VLGWQ----------------------------DANSTEFDPTTSHPVVVDMPEHNPGQM B4DR64_HUMAN B4DR64_HUMAN VLGWQ----------------------------DANSTEFDPTTSHPVVVDMPEHNPGQM B4DMB5_HUMAN B4DMB5_HUMAN VLGWQ----------------------------DANSTEFDPTTSHPVVVDMPEHNPGQM B7Z9C4_HUMAN B7Z9C4_HUMAN ------------------------------------------------------------ PYRG1_CRIGR PYRG1_CRIGR VLGWQ----------------------------DANSTEFDPKTSHPVVIDMPEHNPGQM A0JNE9_BOVIN A0JNE9_BOVIN VLGWQ----------------------------DANSTEFDPNTNHPVVIDMPEHNPGQM Q3TPP2_MOUSE Q3TPP2_MOUSE ------------------------------------------------------------ B1AS53_MOUSE B1AS53_MOUSE VLGWQ----------------------------DANSTEFDPKTSHPVVIDMPEHNPGQM PYRG1_MOUSE PYRG1_MOUSE VLGWQ----------------------------DANSTEFDPKTSHPVVIDMPEHNPGQM B1WC02_RAT B1WC02_RAT VLGWQ----------------------------DANSTEFDPKTSHPVVIDMPEHNPGQM A3QJW5_DANRE A3QJW5_DANRE MLDWT----------------------------DANSTEFDPETKHPVVIDMPEHNPGQM PYRG1_DANRE PYRG1_DANRE MLDWT----------------------------DANSTEFDPETKHPVVIDMPEHNPGQM A9JT21_DANRE A9JT21_DANRE VLGWE----------------------------DANSTEFDPETKHPVVIEMPEHNPGQM B7ZVK1_DANRE B7ZVK1_DANRE VLGWE----------------------------DANSTEFDPETKHPVVIEMPEHNPGQM Q6DBZ3_DANRE Q6DBZ3_DANRE VLGWE----------------------------DANSTEFDPETKHPVV----------- B5X4W4_SALSA B5X4W4_SALSA VLEWE----------------------------DANSTEFHPESKHPVVIDMPEHNPGQM B5X434_SALSA B5X434_SALSA VLGWQ----------------------------DANSTEFHPESKHPVVIDMPEHNPGQM Q4SGG9_TETNG Q4SGG9_TETNG ELGWEGDHHTTVYWFFQISRRTFLTCISFFFGSDANSTEFDPESKHPVVIDMPEHNPGQM Q4THD8_TETNG Q4THD8_TETNG ------------------------------------------------------------ MATCH CONSENSUS ?L???????????????????????????????DANSTEF?P????P?V??MPEHNPG??

B1H2S0_XENTR B1H2S0_XENTR GGTMRLGRRKTVFKTSDSVIKKLYDNYEFVEERHRHRYEVNPELVHQFEEKGLKFVGQDN PYRG2_XENLA PYRG2_XENLA GGTMRLGSRKTVFKTSESVVKKLYDNQDFVEERHRHRYEVNPELVQQFEEKGLKFVGQDN PYRG2_RAT PYRG2_RAT GGTMRLGLRRTVFTTENSILKKLYGDVPYIEERHRHRYEVNPNLINQFENKDLCFVGEDV A2AEQ7_MOUSE A2AEQ7_MOUSE GGTMRLGLRRTVFTTENSILKKLYGDVPYIEERHRHRYEVNPNLINQFENKDLCFVGEDV PYRG2_MOUSE PYRG2_MOUSE GGTMRLGLRRTVFTTENSILKKLYGDVPYIEERHRHRYEVNPNLINQFENKDLCFVGEDV A2AEQ8_MOUSE A2AEQ8_MOUSE GGTMRLGLRRTVFTTENSIL---------------------------------------- A2AEQ6_MOUSE A2AEQ6_MOUSE GGTMRLGLRRTVFTTENSIL---------------------------------------- B3KWM2_HUMAN B3KWM2_HUMAN GGTMRLGIRRTVFKTENSILRKLYGDVPFIEERHRHRFEVNPNLIKQFEQNDLSFVGQDV PYRG2_HUMAN PYRG2_HUMAN GGTMRLGIRRTVFKTENSILRKLYGDVPFIEERHRHRFEVNPNLIKQFEQNDLSFVGQDV PYRG2_BOVIN PYRG2_BOVIN GGTMRLGIRRTVFKTENSILRKLYGDVPFIEERHRHRYEVNPSLISQLEQKDLSFVGQDV PYRG2_CHICK PYRG2_CHICK GGTMRLGKRRTVFKTQNSILRKLYGDEMFVEERHRHRYEVNPELTHCFEEKGLKFVGHDT Q4SYD8_TETNG Q4SYD8_TETNG GGTMRLGKRRTVFKSDTSVMKKLYGNVDFIDERHRHRFEVNPALKDYFVKHGLQFVGQDV PYG1A_XENLA PYG1A_XENLA GGTMRLGKRRTIFHSQNSIMKKLYGGHEYVEERHRHRYEVNPELRRELEVRGLKFVGQDT PYG1B_XENLA PYG1B_XENLA GGTMRLGKRRTIFHSQNSVMKKLYGGHEYVEERHRHRYEVNPELRRELEARGLKFVGQDT B4E1E0_HUMAN B4E1E0_HUMAN GGTMRLGKRRTLFQTKNSVMRKLYGDADYLEERHRHRFEVNPVWKKCLEEQGLKFVGQDV PYRG1_HUMAN PYRG1_HUMAN GGTMRLGKRRTLFQTKNSVMRKLYGDADYLEERHRHRFEVNPVWKKCLEEQGLKFVGQDV B4DR64_HUMAN B4DR64_HUMAN GGTMRLGKRRTLFQTKNSVMRKLYGDADYLEERHRHRFEVNPVWKKCLEEQGLKFVGQDV B4DMB5_HUMAN B4DMB5_HUMAN GGTMRLGKRRTLFQTKNSVMRKLYGDADYLEERHRHRFEVRI------------------ B7Z9C4_HUMAN B7Z9C4_HUMAN ------------------------------------------------------------ PYRG1_CRIGR PYRG1_CRIGR GGTMRLGKSRTLFQTKNSVMSKLYGDTDYLEERHRHRFEVNP------------------ A0JNE9_BOVIN A0JNE9_BOVIN GGTMRLGKRRTLFQTKNSVMRKLYGDPDYLEERHRHRFEVNPVLKKCLEEQGLKFVGQDV Q3TPP2_MOUSE Q3TPP2_MOUSE ------------------------------------------------------------ B1AS53_MOUSE B1AS53_MOUSE GGTMRLGKRRTLFQTKNSVMRKLYGDTDYLEERHRHRFEVNPVLKKCLEEQGLKFVGQDV PYRG1_MOUSE PYRG1_MOUSE GGTMRLGKRRTLFQTKNSVMRKLYGDTDYLEERHRHRFEVNPVLKKCLEEQGLKFVGQDV B1WC02_RAT B1WC02_RAT GGTMRLGKRRTLFQTKNSVMRKLYGDTDYLEERHRHRFEVNPVLKKCLEEQGLKFVGQDV A3QJW5_DANRE A3QJW5_DANRE GGTMRLGKRRTIFKNKSSILRKLYGDVDYVEERHRHRFEVNPELKHHFEEKGFRFVGQDV PYRG1_DANRE PYRG1_DANRE GGTMRLGKRRTIFKNKSSILRKLYGDVDYVEERHRHRFEVNPELKHHFEEKGFRFVGQDV A9JT21_DANRE A9JT21_DANRE GGTMRLGKRRTLFKSTPSILRKLYGDAEYVDERHRHRFEVNPELKHHFEDRGFRFVGQDL B7ZVK1_DANRE B7ZVK1_DANRE GGTMRLGKRRTLLKSTPSILRKLYGDAEYVDERHRHRFEVNPELKHHFEDRGFRFVGQDL Q6DBZ3_DANRE Q6DBZ3_DANRE ---------------------------------------------------GVRLVKQII B5X4W4_SALSA B5X4W4_SALSA GGTMRLGKRRTIFKTTNSILRRLYGDAEYVDERHRHRFEVNPELKDHFEGKGFHFVGQDV B5X434_SALSA B5X434_SALSA GGTMRLGKRRTIFKSNTSILRKLYGDAEYVDERHRHRFEVNPELKHHFEERGFHFVGQDI Q4SGG9_TETNG Q4SGG9_TETNG GGTMRLGKRRTIFRAPGSILRKLYGDAEYVEERHRHRFEVNPELKSHFEDKGFRFVGQDI Q4THD8_TETNG Q4THD8_TETNG ------------------------------------------------------------ MATCH CONSENSUS GGTMRLG?RRT?F????S????LY???????ERHRHR?EV????????????????????

B1H2S0_XENTR B1H2S0_XENTR EGQRMEIIELEGHPYFVGVQFHPEFCSRPMKPSPPYLGFMLAASGKFNSYVQNGCKLSPR PYRG2_XENLA PYRG2_XENLA EGQRMEIIELEGHPYFVGVQFHPEFCSRPMKPSPPYLGFMLAASGKLNTYVQNGCKLSPR PYRG2_RAT PYRG2_RAT DGKRMEIIELTGHPYFIGVQFHPEFSSRPMKPSPPYLGLLLAATGTLNTHLQQMSKLSYS A2AEQ7_MOUSE A2AEQ7_MOUSE DGKRMEIVELTSHPYFIGVQFHPEFSSRPMKPSPPYLGLLLAATGNLNAHLQQMNKLPYS PYRG2_MOUSE PYRG2_MOUSE DGKRMEIVELTSHPYFIGVQFHPEFSSRPMKPSPPYLGLLLAATGNLNAHLQQMNKLPYS A2AEQ8_MOUSE A2AEQ8_MOUSE -----------SHPYFIGVQFHPEFSSRPMKPSPPYLGLLLAATGNLNAHLQQMNKLPYS A2AEQ6_MOUSE A2AEQ6_MOUSE -------------------------------------SLYLQCSG--------------- B3KWM2_HUMAN B3KWM2_HUMAN DGDRMEIIELANHPYFVGVQFHPEFSSRPMKPSPPYLGLLLAATGNLNAYLQQGCKLSSS PYRG2_HUMAN PYRG2_HUMAN DGDRMEIIELANHPYFVGVQFHPEFSSRPMKPSPPYLGLLLAATGNLNAYLQQGCKLSSS PYRG2_BOVIN PYRG2_BOVIN DGERMEIIELANHPYFVGVQFHPEFSSRPMKPSPPYLGLLLAATGNLNAYLLQGCKLSSS PYRG2_CHICK PYRG2_CHICK EGNRMEMIELENHPYFVGVQFHPEFSSRPMKPSPPYLGLLLAATGTLNAYLQRGCKLSPS Q4SYD8_TETNG Q4SYD8_TETNG QGERMEIVELEDHCYFVGVQYHPEFTSRPIKPSPPYFGLLLAAAGKLQSYLSKGCQLSPR PYG1A_XENLA PYG1A_XENLA EGERMEIVELEDHPYFVGVQYHPEFLSRPIKPSPPYFGLLLASVGRLSQYIERGCRLSPR PYG1B_XENLA PYG1B_XENLA EGERMEIVELEDHPYFVGVQYHPEFLSRPIKPSPPYFGLLLASVGRLSQYIERGCRLSPR B4E1E0_HUMAN B4E1E0_HUMAN EGERMEIVELEDHPFFVGVQYHPEFLSRPIKPSPPYFGLLLASVGRLSHYLQKGCRLSPR PYRG1_HUMAN PYRG1_HUMAN EGERMEIVELEDHPFFVGVQYHPEFLSRPIKPSPPYFGLLLASVGRLSHYLQKGCRLSPR B4DR64_HUMAN B4DR64_HUMAN EGERMEIVELEDHPFFVGVQYHPEFLSRPIKPSPPYFGLLLASVGRLSHYLQKGCRLSPR B4DMB5_HUMAN B4DMB5_HUMAN -------------------------------PACWYSGKIVS------------------ B7Z9C4_HUMAN B7Z9C4_HUMAN ------------------------------------------------------------ PYRG1_CRIGR PYRG1_CRIGR ------------------------------------------------------------ A0JNE9_BOVIN A0JNE9_BOVIN EGERMEIVELEDHPFFVGVQYHPEFLSRPIKPSPPYFGLLLASVGRLPHYLQKGCRLSPR Q3TPP2_MOUSE Q3TPP2_MOUSE ------------------------------------------------------------ B1AS53_MOUSE B1AS53_MOUSE EGERMEIVELEDHPFFVGVQYHPEFLSRPIKPSPPYFGLLLASVGRLPHYLQKGCRLSPR PYRG1_MOUSE PYRG1_MOUSE EGERMEIVELEDHPFFVGVQYHPEFLSRPIKPSPPYFGLLLASVGRLPHYLQKGCRLSPR B1WC02_RAT B1WC02_RAT EGERMEIVELEDHPFFVGVQYHPEFLSRPIKPSPPYFGLLLASVGRLPHYLQKGCRLSPR A3QJW5_DANRE A3QJW5_DANRE EGERMEVIEMDDHPYFVGVQYHPEFTSRPIKPSPPYLGLLLAAAGRLQSYLQKGCRLSPR PYRG1_DANRE PYRG1_DANRE EGERMEVIEMDDHPYFVGVQYHPEFTSRPIKPSPPYLGLLLAAAGRLQSYLQKGCRLSPR A9JT21_DANRE A9JT21_DANRE EGERMEIIELEDHTYFVGVQYHPEFTSRPIKPSPPYFGLLLAASGKLQNYLQKGCRLSPR B7ZVK1_DANRE B7ZVK1_DANRE EGERMEIIELEDHTYFVGVQYHPEFTSRPIKPSPPYFGLLLAASGKLHNYLQKGCRLSPR Q6DBZ3_DANRE Q6DBZ3_DANRE ------------------------------------------------------------ B5X4W4_SALSA B5X4W4_SALSA EGERMEVIELDDHPYFVGVQYHPEFTSRPIKPSPPYFGLLLASAGKLQSYLQKGCRLSPR B5X434_SALSA B5X434_SALSA EGERMEVIELDDHAYFVGVQYHPEFTSRPIKPSPPYFGLLLAAAGKLQSYLQKGCRLSPR Q4SGG9_TETNG Q4SGG9_TETNG EGERMEVIELDEHPYFVGVQYHPEFTSRPIKPSPPYLGLLLASAGKLQSYLQKGCRLSPR Q4THD8_TETNG Q4THD8_TETNG ------------------------------------------------------------ MATCH CONSENSUS ???????????????????????????????P???Y?G??L???G???????????????

B1H2S0_XENTR B1H2S0_XENTR NSY-SEHSDESSSDS------------- PYRG2_XENLA PYRG2_XENLA NSY-SEHSDESSSDS------------- PYRG2_RAT PYRG2_RAT DIY-SDASDDSFSEAKFAELDIN----- A2AEQ7_MOUSE A2AEQ7_MOUSE DGY-SDASDDSFPEAKLAELDLN----- PYRG2_MOUSE PYRG2_MOUSE DGY-SDASDDSFPEAKLAELDLN----- A2AEQ8_MOUSE A2AEQ8_MOUSE DGY-SDASDDSFPEAKLAELDLN----- A2AEQ6_MOUSE A2AEQ6_MOUSE ---------------------------- B3KWM2_HUMAN B3KWM2_HUMAN DRY-SDASDDSFSEPRIAELEIS----- PYRG2_HUMAN PYRG2_HUMAN DRY-SDASDDSFSEPRIAELEIS----- PYRG2_BOVIN PYRG2_BOVIN DRY-SDASDDSFSEPRLAELEIS----- PYRG2_CHICK PYRG2_CHICK ESY-SDLSDDSSPEKEFPKSETS----- Q4SYD8_TETNG Q4SYD8_TETNG DMYCCSSSGSSSPEPDITELKF------ PYG1A_XENLA PYG1A_XENLA DTY-SDRSENSSPDAEIAELKLPMIDHD PYG1B_XENLA PYG1B_XENLA DTY-SDRSENSSPDAEIAELKLPMIDHE B4E1E0_HUMAN B4E1E0_HUMAN DTY-SDRSGSSSPDSEITELKFPSINHD PYRG1_HUMAN PYRG1_HUMAN DTY-SDRSGSSSPDSEITELKFPSINHD B4DR64_HUMAN B4DR64_HUMAN DTY-SDRSGSSSPDSEITELKFPSINHD B4DMB5_HUMAN B4DMB5_HUMAN ---------------------------- B7Z9C4_HUMAN B7Z9C4_HUMAN ---------------------------- PYRG1_CRIGR PYRG1_CRIGR ---------------------------- A0JNE9_BOVIN A0JNE9_BOVIN DTY-SDRSGSSSPDSEITELKFPSINHD Q3TPP2_MOUSE Q3TPP2_MOUSE ---------------------------- B1AS53_MOUSE B1AS53_MOUSE DTY-SDRSGSSSPDSEITELKFPSISQD PYRG1_MOUSE PYRG1_MOUSE DTY-SDRSGSSSPDSEITELKFPSISQD B1WC02_RAT B1WC02_RAT DTY-SDRSGSSSPDSEITELKFPSISQD A3QJW5_DANRE A3QJW5_DANRE DAY-SDRSGSSSPDLEIADLKLRSIAQE PYRG1_DANRE PYRG1_DANRE DAY-SDRSGSSSPDLEIADLKLRSIAQE A9JT21_DANRE A9JT21_DANRE DAY-SDRSGTSSPDSEISEFKFPSLS-- B7ZVK1_DANRE B7ZVK1_DANRE DAY-SDRSGTSSPDSEISEFKFPSLS-- Q6DBZ3_DANRE Q6DBZ3_DANRE -IY-T----------------------- B5X4W4_SALSA B5X4W4_SALSA DTY-SDQSGSSTPDSEIAESISQEFV-- B5X434_SALSA B5X434_SALSA DTY-SDRSDSSSPDSEIAELKF------ Q4SGG9_TETNG Q4SGG9_TETNG DTY-SDHSGSSTPDSEISELKLPSISSE Q4THD8_TETNG Q4THD8_TETNG ---------------------------- MATCH CONSENSUS ??Y?????????????????????????


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