Alignment of the gene Family HBG002453 of HOVERGEN

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Isoforms are ON
Q4S976_TETNG Q4S976_TETNG -----------------------------------------------PPSCSLQEWRRRV EZH1_MOUSE EZH1_MOUSE -----------------------------------------MDIASPPTSKCITYWKRKV EZH1_BOVIN EZH1_BOVIN -----------------------------------------MDIPNPPTSKCITYWKRKV EZH1_HUMAN EZH1_HUMAN -----------------------------------------MEIPNPPTSKCITYWKRKV EZH1_PONAB EZH1_PONAB -----------------------------------------MEIPNPPTSKCITYWKRKV B5DFE2_RAT B5DFE2_RAT -----------------------------------------MGQTGKKSEKGPVCWRKRV Q6AXH7_MOUSE Q6AXH7_MOUSE -----------------------------------------MGQTGKKSEKGPVCWRKRV Q571L5_MOUSE Q571L5_MOUSE --------RRQWSPGGGGGGGGGLGATRGRGAGWRAGRRIIMGQTGKKSEKGPVCWRKRV Q3TZH6_MOUSE Q3TZH6_MOUSE -----------------------------------------MGQTGKKSEKGPVCWRKRV EZH2_MOUSE EZH2_MOUSE -----------------------------------------MGQTGKKSEKGPVCWRKRV Q99L74_MOUSE Q99L74_MOUSE -----------------------------------------MGQTGKKSEKGPVCWRKRV Q3U575_MOUSE Q3U575_MOUSE -----------------------------------------MGQTGKKSEKGPVCWRKRV Q59H64_HUMAN Q59H64_HUMAN VRSRPTPGGTQKAVEPRRRRRRRAGATRGNNASRRAGRRIIMGQTGKKSEKGPVCWRKRV B7Z7L6_HUMAN B7Z7L6_HUMAN -----------------------------------------MGQTGKKSEKGPVCWRKRV Q75MQ0_HUMAN Q75MQ0_HUMAN ------------------------------------------------------------ Q96FI6_HUMAN Q96FI6_HUMAN -----------------------------------------MGQTGKKSEKGPVCWRKRV EZH2_MACFA EZH2_MACFA -----------------------------------------MGQTGKKSEKGPVCWRKRV B3KS30_HUMAN B3KS30_HUMAN -----------------------------------------MGQTGKKSEKGPVCWRKRV Q75MP9_HUMAN Q75MP9_HUMAN ------------------------------------------------------------ B2RAQ1_HUMAN B2RAQ1_HUMAN -----------------------------------------MGQTGKKSEKGPVCWRKRV B7Z1D6_HUMAN B7Z1D6_HUMAN -----------------------------------------MGQTGKKSEKGPVCWRKRV EZH2_HUMAN EZH2_HUMAN -----------------------------------------MGQTGKKSEKGPVCWRKRV EZH2B_XENLA EZH2B_XENLA -----------------------------------------MGQTGKKSEKGAVCWRKRV EZH2A_XENLA EZH2A_XENLA -----------------------------------------MGQTGKKSEKGPVCWRKRV EZH2_XENTR EZH2_XENTR -----------------------------------------MGQTGKKSEKGPVCWRKRV Q4TFJ6_TETNG Q4TFJ6_TETNG ---------------------------------------LIMVLTGKRSEKGPACWKRRV EZH2_DANRE EZH2_DANRE -----------------------------------------MGLTGRKSEKGPVCWRRRV Q504B3_DANRE Q504B3_DANRE -----------------------------------------MGLTGRKSEKGPVCWRRRV Q5TKR5_ORYLA Q5TKR5_ORYLA -----------------------------------------MG-TGKRSDKGPACWKRRV Q90WP4_TETNG Q90WP4_TETNG -----------------------------------------MVLTGKRSEKGPACWKRRV MATCH CONSENSUS ?????????????????????????????????????????M????????K????W??RV

Q4S976_TETNG Q4S976_TETNG KSEYMRLRQLKRLKKAEEVKALFMSNRQKIEQQTNLLNAEWSALRIQSIPLYIWLRYPDK EZH1_MOUSE EZH1_MOUSE KSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEWKKLRVQPVQPMKPV----- EZH1_BOVIN EZH1_BOVIN KSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEWKKLRVQPVQLMKPV----- EZH1_HUMAN EZH1_HUMAN KSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEWKKLRVQPVQSMKPV----- EZH1_PONAB EZH1_PONAB KSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEWKKLRVQPVQSMKPV----- B5DFE2_RAT B5DFE2_RAT KSEYMRLRQLKRFRRADEVKTMFSSNRQKILERTETLNQEWKQRRIQPVHIMTSV----- Q6AXH7_MOUSE Q6AXH7_MOUSE KSEYMRLRQLKRFRRADEVKTMFSSNRQKILERTETLNQEWKQRRIQPVHIMTS------ Q571L5_MOUSE Q571L5_MOUSE KSEYMRLRQLKRFRRADEVKTMFSSNRQKILERTETLNQEWKQRRIQPVHIMTSV----- Q3TZH6_MOUSE Q3TZH6_MOUSE KSEYMRLRQLKRFRRADEVKTMFSSNRQKILERTETLNQEWKQRRIQHVHIMTSV----- EZH2_MOUSE EZH2_MOUSE KSEYMRLRQLKRFRRADEVKTMFSSNRQKILERTETLNQEWKQRRIQPVHIMTSV----- Q99L74_MOUSE Q99L74_MOUSE KSEYMRLRQLKRFRRADEVKTMFSSNRQKILERTETLNQEWKQRRIQPVHIMTSV----- Q3U575_MOUSE Q3U575_MOUSE KSEYMRLRQLKRFRRADEVKTMFSSNRQKILERTETLNQEWKQRRIQPVHIMTSV----- Q59H64_HUMAN Q59H64_HUMAN KSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSV----- B7Z7L6_HUMAN B7Z7L6_HUMAN KSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTS------ Q75MQ0_HUMAN Q75MQ0_HUMAN ------------------------------------------------------------ Q96FI6_HUMAN Q96FI6_HUMAN KSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSV----- EZH2_MACFA EZH2_MACFA KSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSV----- B3KS30_HUMAN B3KS30_HUMAN KSEYMRLRQLKRFRRADEVNSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSV----- Q75MP9_HUMAN Q75MP9_HUMAN ------------------------------------------------------------ B2RAQ1_HUMAN B2RAQ1_HUMAN KSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSV----- B7Z1D6_HUMAN B7Z1D6_HUMAN KSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTS------ EZH2_HUMAN EZH2_HUMAN KSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSV----- EZH2B_XENLA EZH2B_XENLA KSEYMRLRQLKRFRRADEVKSMFNTNRQKIMERTEILNQEWKQRRIQPVHIMTTV----- EZH2A_XENLA EZH2A_XENLA KSEYMALRQLKKFRRADEVKSMFNTNRQKIMERTEILNQEWKQRRIQPVHIMTTV----- EZH2_XENTR EZH2_XENTR KSEYMRLRQLKRFRRADEVKSMFNTNRQKIMERTEILNQEWKQRRIQPVHIMTTV----- Q4TFJ6_TETNG Q4TFJ6_TETNG KSEYMRLRQLKRFRRADEIKSMFSTNRQKIMERTDILNQEWKTRRIQPVHIMTSV----- EZH2_DANRE EZH2_DANRE KSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTDILNQEWKLRRIQPVHIMTPV----- Q504B3_DANRE Q504B3_DANRE KSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTDILNQEWKLRRIQPVHIMTPV----- Q5TKR5_ORYLA Q5TKR5_ORYLA KSEYMRLRQMKRFRRADEVKGMFNSNRQKIMERTDILNQEWKTRRIQPIHIMTPV----- Q90WP4_TETNG Q90WP4_TETNG KSEYMRLRQLKRFRRADEIKSMFSTNRQKIMERTDILNQEWKTRRIQPVHIMTSV----- MATCH CONSENSUS KSEYMRLRQLKR???A?E?K??F??NRQKI?E?T??LN?EWK??RIQPV?????V?????

Q4S976_TETNG Q4S976_TETNG ACQTVLQMCTVEFGF----------------PGFKAQ----------------------- EZH1_MOUSE EZH1_MOUSE SGHPFLKKCTIESIF----------------PGFDSQ----------------------- EZH1_BOVIN EZH1_BOVIN SGHPFLKKCTIESIF----------------PGFASQ----------------------- EZH1_HUMAN EZH1_HUMAN SGHPFLKKCTIESIF----------------PGFASQ----------------------- EZH1_PONAB EZH1_PONAB CGHPFLKKCTIESIF----------------PGFASQ----------------------- B5DFE2_RAT B5DFE2_RAT SSLRGTRECSVTSDL-----------------DFPAQ----------------------- Q6AXH7_MOUSE Q6AXH7_MOUSE --------CSVTSDL-----------------DFPAQ----------------------- Q571L5_MOUSE Q571L5_MOUSE SSLRGTRECSVTSDL-----------------DFPAQ----------------------- Q3TZH6_MOUSE Q3TZH6_MOUSE SSLRGTRECSVTSDL-----------------DFPAQ----------------------- EZH2_MOUSE EZH2_MOUSE SSLRGTRECSVTSDL-----------------DFPAQ----------------------- Q99L74_MOUSE Q99L74_MOUSE SSLRGTRECSVTSDL-----------------DFPAQ----------------------- Q3U575_MOUSE Q3U575_MOUSE SSLRGTRECSVTSDL-----------------DFPAQ----------------------- Q59H64_HUMAN Q59H64_HUMAN SSLRGTRECSVTSDL-----------------DFPTQ----------------------- B7Z7L6_HUMAN B7Z7L6_HUMAN --------CSVTSDL-----------------DFPTQ----------------------- Q75MQ0_HUMAN Q75MQ0_HUMAN --------CSVTSDL-----------------DFPTQ----------------------- Q96FI6_HUMAN Q96FI6_HUMAN SSLRGTRECSVTSDL-----------------DFPTQ----------------------- EZH2_MACFA EZH2_MACFA SSLRGTRECSVTSDL-----------------DFPTQ----------------------- B3KS30_HUMAN B3KS30_HUMAN SSLRGTREV--------------------------------------------------- Q75MP9_HUMAN Q75MP9_HUMAN --------CSVTSDL-----------------DFPTQ----------------------- B2RAQ1_HUMAN B2RAQ1_HUMAN SSLRGTREV--------------------------------------------------- B7Z1D6_HUMAN B7Z1D6_HUMAN --------CSVTSDL-----------------DFPTQ----------------------- EZH2_HUMAN EZH2_HUMAN SSLRGTRECSVTSDL-----------------DFPTQ----------------------- EZH2B_XENLA EZH2B_XENLA SSLRGTRECFVTSDL-----------------DFPKQ----------------------- EZH2A_XENLA EZH2A_XENLA SSLRGTRECSVTSDL-----------------DFPKQ----------------------- EZH2_XENTR EZH2_XENTR SSLRGTRECSVTSDL-----------------DFPKQ----------------------- Q4TFJ6_TETNG Q4TFJ6_TETNG GSLRGTREVGTRVCLWAGVLRWRPALRVCLSPVYGGQQLLRVPPAGDPPEDPERRGLGPG EZH2_DANRE EZH2_DANRE SSLRGTRECTVDSGF----------------SEFSRQ----------------------- Q504B3_DANRE Q504B3_DANRE SSLRGTRECTVDSGF----------------SEFSRQ----------------------- Q5TKR5_ORYLA Q5TKR5_ORYLA -SSRGTRECTVDSGF----------------PEFSRQ----------------------- Q90WP4_TETNG Q90WP4_TETNG GSLRGTRECTVDSSF----------------SEFPRQ----------------------- MATCH CONSENSUS ????????C???S????????????????????F??Q???????????????????????

Q4S976_TETNG Q4S976_TETNG ----AVAMRPLSTVAGIPFMYSWSPLQHNFMV-----EDETFLHNIPYMGDDVLEQDEAF EZH1_MOUSE EZH1_MOUSE ----DMLMRSLNTVALVPIMYSWSPLQQNFMV-----EDETVLCNIPYMGDEVKEEDETF EZH1_BOVIN EZH1_BOVIN ----HMLMRSLNTVALVPIMYSWSPLQQNFMV-----EDETVLCNIPYMGDEVKEEDETF EZH1_HUMAN EZH1_HUMAN ----HMLMRSLNTVALVPIMYSWSPLQQNFMV-----EDETVLCNIPYMGDEVKEEDETF EZH1_PONAB EZH1_PONAB ----HMLMRSLNTVALVPIMYSWSPLQQNFMV-----EDETVLCNIPYMGDEVKEEDETF B5DFE2_RAT B5DFE2_RAT ----VIPLKTLNAVASVPIMYSWSPLQQNFMV-----EDETVLHNIPYMGDEVLDQDGTF Q6AXH7_MOUSE Q6AXH7_MOUSE ----VIPLKTLNAVASVPIMYSWSPLQQNFMV-----EDETVLHNIPYMGDEVLDQDGTF Q571L5_MOUSE Q571L5_MOUSE ----VIPLKTLNAVASVPIMYSWSPLQQNFMV-----EDETVLHNIPYMGDEVLDQDGTF Q3TZH6_MOUSE Q3TZH6_MOUSE ----VIPLKTLNAVASVPIMYSWSPLQQNFMV-----EDETVLHNIPYMGDEVLDQDGTF EZH2_MOUSE EZH2_MOUSE ----VIPLKTLNAVASVPIMYSWSPLQQNFMV-----EDETVLHNIPYMGDEVLDQDGTF Q99L74_MOUSE Q99L74_MOUSE ----VIPLKTLNAVASVPIMYSWSPLQQNFMV-----EDETVLHNIPYMGDEVLDQDGTF Q3U575_MOUSE Q3U575_MOUSE ----VIPLKTLNAVASVPIMYSWSPLQQNFMV-----EDETVLHNIPYMGDEVLDQDGTF Q59H64_HUMAN Q59H64_HUMAN ----VIPLKTLNAVASVPIMYSWSPLQQNFMV-----EDETVLHNIPYMGDEVLDQDGTF B7Z7L6_HUMAN B7Z7L6_HUMAN ----VIPLKTLNAVASVPIMYSWSPLQQNFMV-----EDETVLHNIPYMGDEVLDQDGTF Q75MQ0_HUMAN Q75MQ0_HUMAN ----VIPLKTLNAVASVPIMYSWSPLQQNFMV-----EDETVLHNIPYMGDEVLDQDGTF Q96FI6_HUMAN Q96FI6_HUMAN ----VIPLKTLNAVASVPIMYSWSPLQQNFMV-----EDETVLHNIPYMGDEVLDQDGTF EZH2_MACFA EZH2_MACFA ----VIPLKTLNAVASVPIMYSWSPLQQNFMV-----EDETVLHNIPYMGDEVLDQDGTF B3KS30_HUMAN B3KS30_HUMAN -------------------------------------EDETVLHNIPYMGDEVLDQDGTF Q75MP9_HUMAN Q75MP9_HUMAN ----VIPLKTLNAVASVPIMYSWSPLQQNFMV-----EDETVLHNIPYMGDEVLDQDGTF B2RAQ1_HUMAN B2RAQ1_HUMAN -------------------------------------EDETVLHNIPYMGDEVLDQDGTF B7Z1D6_HUMAN B7Z1D6_HUMAN ----VIPLKTLNAVASVPIMYSWSPLQQNFMV-----EDETVLHNIPYMGDEVLDQDGTF EZH2_HUMAN EZH2_HUMAN ----VIPLKTLNAVASVPIMYSWSPLQQNFMV-----EDETVLHNIPYMGDEVLDQDGTF EZH2B_XENLA EZH2B_XENLA ----VIPLKTLTAVASMPIMYSWSPLQQNFMV-----EDETVLHNIPYMGDEVLDQDGTF EZH2A_XENLA EZH2A_XENLA ----VIPLKTLTAVASVPIMYSWSPLQQNFMV-----EDETVLHNIPYMGDEVLDQDGTF EZH2_XENTR EZH2_XENTR ----VIPLKTLTAVASVPIMYSWSPLQQNFMV-----EDETVLHNIPYMGDEVLDQDGTF Q4TFJ6_TETNG Q4TFJ6_TETNG HVLLVAPAAELHGETCVNAALDSGGVADGGLVVDRQWEDETVLHNIPYMGDEILDQDGTF EZH2_DANRE EZH2_DANRE ----VIPLKTLNAVASVPVMYSWSPLQQNFMV-----EDETVLHNIPYMGDEILDQDGTF Q504B3_DANRE Q504B3_DANRE ----VIPLKTLNAVASVPVMYSWSPLQQNFMV-----EDETVLHNIPYMGDEILDQDGTF Q5TKR5_ORYLA Q5TKR5_ORYLA ----VIPLKTLNAVASVPVMYSWSPLQQNFMV-----EDETVLHNIPYMGDEILDQDGTF Q90WP4_TETNG Q90WP4_TETNG ----VIPLKTLNAVASVPVMYSWSPLQQNFMV-----EDETVLHNIPYMGDEILDQDGTF MATCH ****.* *******:: ::* :* CONSENSUS ??????????L??VA?VP?MYSWSPLQQNFMV?????EDETVLHNIPYMGDEVLDQDGTF

Q4S976_TETNG Q4S976_TETNG LEELIDNYDG-VHGDR---------------VLVISVLEG--G--FISDEIFKELVEALS EZH1_MOUSE EZH1_MOUSE IEELINNYDGKVHGEE----------------------EMIPGSVLISDAVFLELVDALN EZH1_BOVIN EZH1_BOVIN IEELINNYDGKVHGEE----------------------EMIPGSVLISDAVFLELVDALN EZH1_HUMAN EZH1_HUMAN IEELINNYDGKVHGEE----------------------EMIPGSVLISDAVFLELVDALN EZH1_PONAB EZH1_PONAB IEELINNYDGKVHGEE----------------------EMIPGSVLISDAVFLELVDALN B5DFE2_RAT B5DFE2_RAT IEELIKNYDGKVHGDR----------------------EC--G--FINDEIFVELVNALG Q6AXH7_MOUSE Q6AXH7_MOUSE IEELIKNYDGKVHGDR----------------------EC--G--FINDEIFVELVNALG Q571L5_MOUSE Q571L5_MOUSE IEELIKNYDGKVHGDR----------------------EC--G--FINDEIFVELVNALG Q3TZH6_MOUSE Q3TZH6_MOUSE IEELIKNYDGKVHGDR----------------------EC--G--FINDEIFVELVNALG EZH2_MOUSE EZH2_MOUSE IEELIKNYDGKVHGDR----------------------EC--G--FINDEIFVELVNALG Q99L74_MOUSE Q99L74_MOUSE IEELIKNYDGKVHGDR----------------------EC--G--FINDEIFVELVNALG Q3U575_MOUSE Q3U575_MOUSE IEELIKNYDGKVHGDR----------------------EC--G--FINDEIFVELVNALG Q59H64_HUMAN Q59H64_HUMAN IEELIKNYDGKVHGDR----------------------EC--G--FINDEIFVELVNALG B7Z7L6_HUMAN B7Z7L6_HUMAN IEELIKNYDGKVHGDR----------------------EC--G--FINDEIFVELVNALG Q75MQ0_HUMAN Q75MQ0_HUMAN IEELIKNYDGKVHGDR----------------------EC--G--FINDEIFVELVNALG Q96FI6_HUMAN Q96FI6_HUMAN IEELIKNYDGKVHGDR----------------------EC--G--FINDEIFVELVNALG EZH2_MACFA EZH2_MACFA IEELIKNYDGKVHGDR----------------------EC--G--FINDEIFVELVNALG B3KS30_HUMAN B3KS30_HUMAN IEELIKNYDGKVHGDR----------------------EC--G--FINDEIFVELVNALG Q75MP9_HUMAN Q75MP9_HUMAN IEELIKNYDGKVHGDR----------------------EC--G--FINDEIFVELVNALG B2RAQ1_HUMAN B2RAQ1_HUMAN IEELIKNYDGKVHGDR----------------------EC--G--FINDEIFVELVNALG B7Z1D6_HUMAN B7Z1D6_HUMAN IEELIKNYDGKVHGDR----------------------EC--G--FINDEIFVELVNALG EZH2_HUMAN EZH2_HUMAN IEELIKNYDGKVHGDR----------------------EC--G--FINDEIFVELVNALG EZH2B_XENLA EZH2B_XENLA IEELIKNYDGKVHGDR----------------------EC--G--FINDEIFVELVNALA EZH2A_XENLA EZH2A_XENLA IEELIKNYDGKVHGDR----------------------EC--G--FINDEIFVELVNALA EZH2_XENTR EZH2_XENTR IEELIKNYDGKVHGDR----------------------EC--G--FINDEIFVELVNALA Q4TFJ6_TETNG Q4TFJ6_TETNG IEELIKNYDGKVHGDRGGEHLPPARGQDAQLQRSVCATEC--G--FINDEIFVELVNALA EZH2_DANRE EZH2_DANRE IEELIKNYDGKVHGDR----------------------EC--G--FINDEIFVELVNALN Q504B3_DANRE Q504B3_DANRE IEELIKNYDGKVHGDR----------------------EC--G--FINDEIFVELVNALN Q5TKR5_ORYLA Q5TKR5_ORYLA IEELIKNYDGKVHGDR----------------------EC--G--FINDEIFVELVNALV Q90WP4_TETNG Q90WP4_TETNG IEELIKNYDGKVHGDR----------------------EC--G--FINDEIFVELVNALA MATCH :****.**** ***:. * * :*.* :* ***:** CONSENSUS IEELIKNYDGKVHGDR??????????????????????EC??G??FINDEIFVELVNAL?

Q4S976_TETNG Q4S976_TETNG QYSDHEDEEEEEAAAATAEAMKKREDERVMRRSSLEASEDSRPGTVPFMRRKRRNTADVR EZH1_MOUSE EZH1_MOUSE QYSDEEEDGHND---------P-SDGKQDDSKEDL---PVTRKRKR--------HAIEGN EZH1_BOVIN EZH1_BOVIN QYSDEDEEGHND---------T-SDGKQDDSKEDL---PVTRKRKR--------HAIEGS EZH1_HUMAN EZH1_HUMAN QYSDEEEEGHND---------T-SDGKQDDSKEDL---PVTRKRKR--------HAIEGN EZH1_PONAB EZH1_PONAB QYSDEEEEGHND---------T-SDGKQDDSKEDL---PVTRKRKR--------HAIEGN B5DFE2_RAT B5DFE2_RAT QYNDDDDDDDGD---------D--PDEREEKQKDL---DDSRDDKE-------------- Q6AXH7_MOUSE Q6AXH7_MOUSE QYNDDDDDDDGD---------D--PDEREEKQKDL---EDNRDDKE-------------- Q571L5_MOUSE Q571L5_MOUSE QYNDDDDDDDGD---------D--PDEREEKQKDL---EDNRDDKE-------------- Q3TZH6_MOUSE Q3TZH6_MOUSE QYNDDDDDDDGD---------D--PDEREEKQKDL---EDNRDDKE-------------- EZH2_MOUSE EZH2_MOUSE QYNDDDDDDDGD---------D--PDEREEKQKDL---EDNRDDKE-------------- Q99L74_MOUSE Q99L74_MOUSE QYNDDDDDDDGD---------D--PDEREEKQKDL---EDNRDDKE-------------- Q3U575_MOUSE Q3U575_MOUSE QYNDDDDDDDGD---------D--PDEREEKQKDL---EDNRDDKE-------------- Q59H64_HUMAN Q59H64_HUMAN QYNDDDDDDDGD---------D--PEEREEKQKDL---EDHRDDKE-------------- B7Z7L6_HUMAN B7Z7L6_HUMAN QYNDDDDDDDGD---------D--PEEREEKQKDL---EDHRDDKE-------------- Q75MQ0_HUMAN Q75MQ0_HUMAN QYNDDDDDDDGD---------D--PEEREEKQKDL---EDHRDDKE-------------- Q96FI6_HUMAN Q96FI6_HUMAN QYNDDDDDDDGD---------D--PEEREEKQKDL---EDHRDDKE-------------- EZH2_MACFA EZH2_MACFA QYNDDDDDDDGD---------D--PEEREEKQKDL---EDHRDDKE-------------- B3KS30_HUMAN B3KS30_HUMAN QYNDDDDDDDGD---------D--PEEREEKQKDL---EDHRDDKE-------------- Q75MP9_HUMAN Q75MP9_HUMAN QYNDDDDDDDGD---------D--PEEREEKQKDL---EDHRDDKE-------------- B2RAQ1_HUMAN B2RAQ1_HUMAN QYNDDDDDDDGD---------D--PEEREEKQKDL---EDHRDDKE-------------- B7Z1D6_HUMAN B7Z1D6_HUMAN QYNDDDDDDDGD---------D--PEEREEKQKDL---EDHRDDKE-------------- EZH2_HUMAN EZH2_HUMAN QYNDDDDDDDGD---------D--PEEREEKQKDL---EDHRDDKE-------------- EZH2B_XENLA EZH2B_XENLA QYSDYEDDEDGE---------DNQDDERDDITKDQ---DDNMEEKE-------------- EZH2A_XENLA EZH2A_XENLA QYSDYEDDEDGD---------DNQDDEQDDTAKDQ---DDNMEDKE-------------- EZH2_XENTR EZH2_XENTR QYSDYEDDEDGD---------DNQDDERDDTAKDQ---DDNMEDQE-------------- Q4TFJ6_TETNG Q4TFJ6_TETNG QYSDNEDEEEEE------------EHDFKVDKIDL---CDSRSGAD-------------- EZH2_DANRE EZH2_DANRE QYSDNEEDDEED---------D--HHDYKFEKMDL---CDGKDDAEDHKEQ---LSSESH Q504B3_DANRE Q504B3_DANRE QYSDNEENDEED---------D--HHDYKFEKMDL---CDGKDDAEDHKEQ---LSSESH Q5TKR5_ORYLA Q5TKR5_ORYLA QYSDN-EDDEED---------E--EQDYKVDKMDL---CDGKDHTEDPCKDGH-SNESRA Q90WP4_TETNG Q90WP4_TETNG QYSDNEDEEEEE------------EHDFKVDKIDL---CDSKKHPEDGRKDGLVNNEGRS MATCH **.* :: . : . . CONSENSUS QY?D???????D?????????????????????DL????D?????E??????????????

Q4S976_TETNG Q4S976_TETNG DSSSSKKVPNDKIFTAIASMFPYKGTMEELKEKYKDLLEPPSTVKLLPLCTPNLDGPFAK EZH1_MOUSE EZH1_MOUSE KKSSKKQFPNDMIFSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAK EZH1_BOVIN EZH1_BOVIN KKSSKKQFPNDMIFSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAK EZH1_HUMAN EZH1_HUMAN KKSSKKQFPNDMIFSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAK EZH1_PONAB EZH1_PONAB KKSSKKQFPNDMIFSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAK B5DFE2_RAT B5DFE2_RAT -TCPPRKFPADKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAK Q6AXH7_MOUSE Q6AXH7_MOUSE -TCPPRKFPADKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAK Q571L5_MOUSE Q571L5_MOUSE -TCPPRKFPADKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAK Q3TZH6_MOUSE Q3TZH6_MOUSE -TCPPRKFPADKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAK EZH2_MOUSE EZH2_MOUSE -TCPPRKFPADKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAK Q99L74_MOUSE Q99L74_MOUSE -TCPPRKFPADKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAK Q3U575_MOUSE Q3U575_MOUSE -TCPPRKFPADKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAK Q59H64_HUMAN Q59H64_HUMAN -SRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAK B7Z7L6_HUMAN B7Z7L6_HUMAN -SRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAK Q75MQ0_HUMAN Q75MQ0_HUMAN -SRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAK Q96FI6_HUMAN Q96FI6_HUMAN -SRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAK EZH2_MACFA EZH2_MACFA -SRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAK B3KS30_HUMAN B3KS30_HUMAN -SRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAK Q75MP9_HUMAN Q75MP9_HUMAN -SRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAK B2RAQ1_HUMAN B2RAQ1_HUMAN -SRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAK B7Z1D6_HUMAN B7Z1D6_HUMAN -SRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAK EZH2_HUMAN EZH2_HUMAN -SRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAK EZH2B_XENLA EZH2B_XENLA -TLPLRKFPSDKIFEAISSVFPDKGTSEELKEKYKELTEQQLPGALPPECTPNIDGSNAK EZH2A_XENLA EZH2A_XENLA -TQPLRKFPSDKIFEAISSMFPDKGTSEELKEKYKELTEQQLPGALPPECTPNIDGPNAK EZH2_XENTR EZH2_XENTR -TQPLRKFPSDKIFEAISSMFPDKGTLEELKEKYKELTEQQLPGALPPECTPNIDGPNAK Q4TFJ6_TETNG Q4TFJ6_TETNG ---GSKKFPSDKIFEAISAMFPDKGSTEELKEKYKELTEQQMPGALPPECTPNIDGPHAR EZH2_DANRE EZH2_DANRE NNDGSKKFPSDKIFEAISSMFPDKGSTEELKEKYKELTEQQLPGALPPECTPNIDGPNAK Q504B3_DANRE Q504B3_DANRE NNDGSKKFPSDKIFEAISSMFPDKGSTEELKEKYKELTEQQLPGALPPECTPNIDGPNAK Q5TKR5_ORYLA Q5TKR5_ORYLA NSDGSKKFPSDKIFEAISSMFPDKGSLEELKEKYKELTEQQLPGALPPECTPNIDGPNAR Q90WP4_TETNG Q90WP4_TETNG GADGSKKFPSDKIFEAISAMFPDKGSTEELKEKYKELTEQQMPGALPPECTPNIDGPHAR MATCH ::.* * ** **:::** :* :::**:*::* * . * * ****:**. *: CONSENSUS ??????KFP?DKIFEAISSMFPDKG??EELKEKYKELTEQQ?PGALPPECTPNIDGPNAK

Q4S976_TETNG Q4S976_TETNG SVQREQSLHSFHTLFCRRCFKYDCFLH------PFHATPNVYKRKSKEIHIMTEPCGENC EZH1_MOUSE EZH1_MOUSE SVQREQSLHSFHTLFCRRCFKYDCFLH------PFHATPNVYKRKNKEIKIEPEPCGTDC EZH1_BOVIN EZH1_BOVIN SVQREQSLHSFHTLFCRRCFKYDCFLH------PFHATPNVYKRKNKEIKIEPEPCGTDC EZH1_HUMAN EZH1_HUMAN SVQREQSLHSFHTLFCRRCFKYDCFLH------PFHATPNVYKRKNKEIKIEPEPCGTDC EZH1_PONAB EZH1_PONAB SVQREQSLHSFHTLFCRRCFKYDCFLH------PFHATPNVYKRKNKEIKIEPEPCGTDC B5DFE2_RAT B5DFE2_RAT SVQREQSLHSFHTLFCRRCFKYDCFLH------PFHATPNTYKRKNTETALDNKPCGPQC Q6AXH7_MOUSE Q6AXH7_MOUSE SVQREQSLHSFHTLFCRRCFKYDCFLHRKC-SYSFHATPNTYKRKNTETALDNKPCGPQC Q571L5_MOUSE Q571L5_MOUSE SVQREQSLHSFHTLFCRRCFKYDCFLH------PFHATPNTYKRKNTETALDNKPCGPQC Q3TZH6_MOUSE Q3TZH6_MOUSE SVQREQSLHSFHTLFCRRCFKYDCFLH------PFHATPNTYKRKNTETALDNKPCGPQC EZH2_MOUSE EZH2_MOUSE SVQREQSLHSFHTLFCRRCFKYDCFLH------PFHATPNTYKRKNTETALDNKPCGPQC Q99L74_MOUSE Q99L74_MOUSE SVQREQSLHSFHTLFCRRCFKYDCFLH------PFHATPNTYKRKNTETALDNKPCGPQC Q3U575_MOUSE Q3U575_MOUSE SVQREQSLHSFHTLFCRRCFKYDCFLH------PFHATPNTYKRKNTETALDNKPCGPQC Q59H64_HUMAN Q59H64_HUMAN SVQREQSLHSFHTLFCRRCFKYDCFLH------PFHATPNTYKRKNTETALDNKPCGPQC B7Z7L6_HUMAN B7Z7L6_HUMAN SVQREQSLHSFHTLFCRRCFKYDCFLH------PFHATPNTYKRKNTETALDNKPCGPQC Q75MQ0_HUMAN Q75MQ0_HUMAN SVQREQSLHSFHTLFCRRCFKYDCFLHRKC-NYSFHATPNTYKRKNTETALDNKPCGPQC Q96FI6_HUMAN Q96FI6_HUMAN SVQREQSLHSFHTLFCRRCFKYDCFLHRKC-NYSFHATPNTYKRKNTETALDNKPCGPQC EZH2_MACFA EZH2_MACFA SVQREQSLHSFHTLFCRRCFKYDCFLH------PFHATPNAYKRKNTETALDNKPCGPQC B3KS30_HUMAN B3KS30_HUMAN SVQREQSLHSFHTLFCRRCFKYDCFLH------PFHATPNTYKRKNTETALDNKPCGPQC Q75MP9_HUMAN Q75MP9_HUMAN SVQREQSLHSFHTLFCRRCFKYDCFLH------PFHATPNTYKRKNTETALDNKPCGPQC B2RAQ1_HUMAN B2RAQ1_HUMAN SVQREQSLHSFHTLFCRRCFKYDCFLH------PFHATPNTYKRKNTETALDNKPCGPQC B7Z1D6_HUMAN B7Z1D6_HUMAN SVQREQSLHSFHTLFCRRCFKYDCFLH------PFHATPNTYKRKNTETALDNKPCGPQC EZH2_HUMAN EZH2_HUMAN SVQREQSLHSFHTLFCRRCFKYDCFLH------PFHATPNTYKRKNTETALDNKPCGPQC EZH2B_XENLA EZH2B_XENLA SVQREQSLHSFHTLFCRRCFKYDCFLH------PFHATPNTYKRKNNEAANDGKLCGPYC EZH2A_XENLA EZH2A_XENLA SVQREQSLHSFHTLFCRPCFKYDCFLH------PFHATPNTYKRKNNEAANDGKPCGPHC EZH2_XENTR EZH2_XENTR SVQREQSLHSFHTLFCRRCFKYDCFLH------PFHATPNTYKRKNNEAANDGKPCGPHC Q4TFJ6_TETNG Q4TFJ6_TETNG SVQREQSLHSFHTLFCRRCFKYDCFLHREHGNHSFHATPNTYKRKNLENLVDSKP----- EZH2_DANRE EZH2_DANRE SVQREQSLHSFHTLFCRRCFKYDCFLH------PFQATPNTYKRKNMENLVDSKPCGIYC Q504B3_DANRE Q504B3_DANRE SVQREQSLHSFHTLFCRRCFKYDCFLH------PFHATPNTYKRKNMENLVDSKPCGIYC Q5TKR5_ORYLA Q5TKR5_ORYLA SVQREQSLHSFHTLFCRRCFKYDCFLH------PFHATPNTYKRKNLENLVESKPCGIDC Q90WP4_TETNG Q90WP4_TETNG SVQREQSLHSFHTLFCRRCFKYDCFLH------PFHATPNTYKRKNLENLVDSKPCGLDC MATCH ***************** ********* .*:****.****. * : CONSENSUS SVQREQSLHSFHTLFCRRCFKYDCFLH??????PFHATPNTYKRKN?E???D?KPCG??C

Q4S976_TETNG Q4S976_TETNG FLLQ--KG-AKEFVD-------QNMLRSQRSRKHRRQPRPHVSNCPG-PSQSAEESKPGD EZH1_MOUSE EZH1_MOUSE FLLL--EG-AKEYAM------LHNPRSKCSGRRRRRHP-VVSASCSNASASAMAETKEGD EZH1_BOVIN EZH1_BOVIN FLLL--EG-AKEYAM------LHNPRSKCSGRRRRRHH-VVNASCSNTSASAVAETKEGD EZH1_HUMAN EZH1_HUMAN FLLL--EG-AKEYAM------LHNPRSKCSGRRRRRHH-IVSASCSNASASAVAETKEGD EZH1_PONAB EZH1_PONAB FLLL--EG-AKEYAM------LHNPRSKCSGRRRRRHH-IVSASCSNASASAVAETKEGD B5DFE2_RAT B5DFE2_RAT YQHL--EG-AKEFAAALTAERIKTPPKRPGGRRRGRLP--NNSSRPSTPTISVLESKDTD Q6AXH7_MOUSE Q6AXH7_MOUSE YQHL--EG-AKEFAAALTAERIKTPPKRPGGRRRGRLP--NNSSRPSTPTISVLESKDTD Q571L5_MOUSE Q571L5_MOUSE YQHL--EG-AKEFAAALTAERIKTPPKRPGGRRRGRLP--NNSSRPSTPTISVLESKDTD Q3TZH6_MOUSE Q3TZH6_MOUSE YQHL--EG-AKEFAAALTAERIKTPPKRPGGRRRGRLP--NNSSRPSTPTISVLESKDTD EZH2_MOUSE EZH2_MOUSE YQHL--EG-AKEFAAALTAERIKTPPKRPGGRRRGRLP--NNSSRPSTPTISVLESKDTD Q99L74_MOUSE Q99L74_MOUSE YQHL--EG-AKEFAAALTAERIKTPPKRPGGRRRGRLP--NNSSRPSTPTISVLESKDTD Q3U575_MOUSE Q3U575_MOUSE YQHL--EG-AKEFAAALTAERIKTPPKRPGGRRRGRLP--NNSSRPSTPTISVLESKDTD Q59H64_HUMAN Q59H64_HUMAN YQHL---------------------------------P---------------------- B7Z7L6_HUMAN B7Z7L6_HUMAN YQHL--EG-AKEFAAALTAERIKTPPKRPGGRRRGRLP--NNSSRPSTPTINVLESKDTD Q75MQ0_HUMAN Q75MQ0_HUMAN YQHL--EG-AKEFAAALTAERIKTPPKRPGGRRRGRLP--NNSSRPSTPTINVLESKDTD Q96FI6_HUMAN Q96FI6_HUMAN YQHL--EG-AKEFAAALTAERIKTPPKRPGGRRRGRLP--NNSSRPSTPTINVLESKDTD EZH2_MACFA EZH2_MACFA YQHL--EG-AKEFAAALTAERIKTPPKRPGGRRRGRLP--NNSSRPSTPTINVLESKDTD B3KS30_HUMAN B3KS30_HUMAN YQHL--EG-AKEFAAALTAERIKTPPKRPGGRRRGRLP--NNSSRPSTPTINVLESKDTD Q75MP9_HUMAN Q75MP9_HUMAN YQHL--EG-AKEFAAALTAERIKTPPKRPGGRRRGRLP--NNSSRPSTPTINVLESKDTD B2RAQ1_HUMAN B2RAQ1_HUMAN YQHL--EG-AKEFAAALTAERIKTPPKRPGGRRRGRLP--NNSSRPSTPTINVLESKDTD B7Z1D6_HUMAN B7Z1D6_HUMAN YQHL--EG-AKEFAAALTAERIKTPPKRPGGRRRGRLP--NNSSRPSTPTINVLESKDTD EZH2_HUMAN EZH2_HUMAN YQHL--EG-AKEFAAALTAERIKTPPKRPGGRRRGRLP--NNSSRPSTPTINVLESKDTD EZH2B_XENLA EZH2B_XENLA YQLL--EG-AREFAAALTAEIIKTPPKRPSGRRRGRLP--NNSSRPSTPTVNVLEAKDTD EZH2A_XENLA EZH2A_XENLA YQLL--EG-AREFAAALTAERIKTPPKRPSGRRRGRLP--NNTSRPSTPTVNVSEAKDTD EZH2_XENTR EZH2_XENTR YQLL--EG-AREFAAALTAERIKTPPKRPSGRRRGRLP--NNTSRPSTPTVNVLEAKDTD Q4TFJ6_TETNG Q4TFJ6_TETNG ------------------------------------------------------------ EZH2_DANRE EZH2_DANRE YMYMVQDGMVREYPAGVVPERAKTPSKRSTGRRRGRLP--NSNSRPSTPTVN-SETKDTD Q504B3_DANRE Q504B3_DANRE YMYMVQDGMVREYPAGVVPERAKTPSKRSTGRRRGRLP--NSNSRPSTPTVN-SETKDTD Q5TKR5_ORYLA Q5TKR5_ORYLA YMYLVQDGMFREFPAGVVAERAKTPSKRSVGRRRGRQPNSNSSSRPSTPTIS-SETKDAD Q90WP4_TETNG Q90WP4_TETNG YMYLVQDGMASEYAAG--AERTKTPSKRPAGRRRGRQP--NSSSRPSTPTVS-SESKDAD MATCH CONSENSUS Y??L???G?A?E?A??????????P?????GRRR?R?P?????S?P?TP?????E?K??D

Q4S976_TETNG Q4S976_TETNG SDHE--TTSSSEKPLQSVFFFLLSYVCITEGNSRCQTPTKLRPGDDDV----TEQESSVV EZH1_MOUSE EZH1_MOUSE SDRDTGN---------------DWASSSSEANSRCQTPTKQKASPAPAQLCVVEAPSEPV EZH1_BOVIN EZH1_BOVIN SDRDTGN---------------DWASSSSEANSRCQTPTKQKASPAPPQLCVVEAPSEPV EZH1_HUMAN EZH1_HUMAN SDRDTGN---------------DWASSSSEANSRCQTPTKQKASPAPPQLCVVEAPSEPV EZH1_PONAB EZH1_PONAB SDRDTGN---------------DWASSSSEANSRCQTPTKQKASPAPPQLCVVEAPSEPV B5DFE2_RAT B5DFE2_RAT SDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPP---------ENV Q6AXH7_MOUSE Q6AXH7_MOUSE SDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPP---------ENV Q571L5_MOUSE Q571L5_MOUSE SDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPP---------ENV Q3TZH6_MOUSE Q3TZH6_MOUSE SDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPP---------ENV EZH2_MOUSE EZH2_MOUSE SDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPP---------ENV Q99L74_MOUSE Q99L74_MOUSE SDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPP---------ENV Q3U575_MOUSE Q3U575_MOUSE SDREAGTETGGE------------------------------------------------ Q59H64_HUMAN Q59H64_HUMAN ------------------------------------------------------------ B7Z7L6_HUMAN B7Z7L6_HUMAN SDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPP---------ENV Q75MQ0_HUMAN Q75MQ0_HUMAN SDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPP---------ENV Q96FI6_HUMAN Q96FI6_HUMAN SDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPP---------ENV EZH2_MACFA EZH2_MACFA SDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPP---------ENV B3KS30_HUMAN B3KS30_HUMAN SDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPP---------ENV Q75MP9_HUMAN Q75MP9_HUMAN SDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPP---------ENV B2RAQ1_HUMAN B2RAQ1_HUMAN SDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPP---------ENV B7Z1D6_HUMAN B7Z1D6_HUMAN SDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPP---------ENV EZH2_HUMAN EZH2_HUMAN SDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPP---------ENV EZH2B_XENLA EZH2B_XENLA SDREAGTETGGESNDKEEEEKKDETDSSSEANSRCQTPIKMKPNIEPP---------ENV EZH2A_XENLA EZH2A_XENLA SDREAGTETGGESNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPP---------ENV EZH2_XENTR EZH2_XENTR SDREAGTETGGESNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPP---------ENV Q4TFJ6_TETNG Q4TFJ6_TETNG ------------------------------------------------------------ EZH2_DANRE EZH2_DANRE SDREGGAD-GNDSNDKDDDDKKDETTSSSEANSRCQTPVKLKLSSEPP---------ENV Q504B3_DANRE Q504B3_DANRE SDREGGAD-GNDSNDKDDDDKKDETTSSSEANSRCQTPVKLKLSSEPP---------ENV Q5TKR5_ORYLA Q5TKR5_ORYLA SDREDGKE-DERDNDKDDEDKKDETTSSSEGNSRCQTPVKMKLTGEA----------EAV Q90WP4_TETNG Q90WP4_TETNG SDRE-GSKEDERENEKDEDDKKDENTSSSEGNSRCQTPVKMKLVGEA----------EAV MATCH CONSENSUS SDRE?G????????????????D???SSSEANSRCQTP?K?K????P??????????E?V

Q4S976_TETNG Q4S976_TETNG QWSGAEESLFRVLHGTYFNNFCSIARLIGTKNCKQVYEFAVKEV-LIHRVPLVDGGISPQ EZH1_MOUSE EZH1_MOUSE EWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKES-LILKLPTDELMNPAQ EZH1_BOVIN EZH1_BOVIN EWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKES-LILKLPTDELMNPSQ EZH1_HUMAN EZH1_HUMAN EWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKES-LILKLPTDELMNPSQ EZH1_PONAB EZH1_PONAB EWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKES-LILKLPTDELMNPSQ B5DFE2_RAT B5DFE2_RAT EWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPVPTEDVDTPPR Q6AXH7_MOUSE Q6AXH7_MOUSE EWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPVPTEDVDTPPR Q571L5_MOUSE Q571L5_MOUSE EWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPVPTEDVDTPPR Q3TZH6_MOUSE Q3TZH6_MOUSE EWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPVPTEDVDTPPR EZH2_MOUSE EZH2_MOUSE EWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPVPTEDVDTPPR Q99L74_MOUSE Q99L74_MOUSE EWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPVPTEDVDTPPR Q3U575_MOUSE Q3U575_MOUSE ------------------------------------------------------------ Q59H64_HUMAN Q59H64_HUMAN ------------------------------------------------------------ B7Z7L6_HUMAN B7Z7L6_HUMAN EWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPR Q75MQ0_HUMAN Q75MQ0_HUMAN EWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPR Q96FI6_HUMAN Q96FI6_HUMAN EWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPR EZH2_MACFA EZH2_MACFA EWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPR B3KS30_HUMAN B3KS30_HUMAN EWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPR Q75MP9_HUMAN Q75MP9_HUMAN EWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPR B2RAQ1_HUMAN B2RAQ1_HUMAN EWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPR B7Z1D6_HUMAN B7Z1D6_HUMAN EWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPR EZH2_HUMAN EZH2_HUMAN EWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPR EZH2B_XENLA EZH2B_XENLA EWSGAEASLFRVLIGTYYDNFCAIARLISTKTCRQVYEFRVKESSIIAPVIAEDVDTPPR EZH2A_XENLA EZH2A_XENLA EWSGAEASLFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIISPVIAEDVDTPPR EZH2_XENTR EZH2_XENTR EWSGAEASLFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPVIAEDVDTPPR Q4TFJ6_TETNG Q4TFJ6_TETNG ------------------------------------------------------------ EZH2_DANRE EZH2_DANRE DWSGAEASLFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIARAPAVDENTPQR Q504B3_DANRE Q504B3_DANRE DWSGAEASLFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIARAPAVDENTPQK Q5TKR5_ORYLA Q5TKR5_ORYLA EWSGAEASLFRVLIGTYYDNFLAIARLIGTKTCRQVYEFRVKESAIIARAPAEDEDTPPR Q90WP4_TETNG Q90WP4_TETNG DWNGAEASLFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIARAPAEDEDTPPR MATCH CONSENSUS ?W?GAE?S?FRV??GTY??NFC?IARL?GTKTC?QV??F?VKES??I???P??????P??

Q4S976_TETNG Q4S976_TETNG KKKRKHR------HDITIDYNNSSNQVYNYQPCDHPDHPCDSSCPCVMTQNFCEKFCLCE EZH1_MOUSE EZH1_MOUSE KKKRKHRLWAAHCRKIQLKKDNNSTQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCS EZH1_BOVIN EZH1_BOVIN KKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCN EZH1_HUMAN EZH1_HUMAN KKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCN EZH1_PONAB EZH1_PONAB KKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCN B5DFE2_RAT B5DFE2_RAT KKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCS Q6AXH7_MOUSE Q6AXH7_MOUSE KKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCS Q571L5_MOUSE Q571L5_MOUSE KKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCS Q3TZH6_MOUSE Q3TZH6_MOUSE KKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCS EZH2_MOUSE EZH2_MOUSE KKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCS Q99L74_MOUSE Q99L74_MOUSE KKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCS Q3U575_MOUSE Q3U575_MOUSE ------------------------------------------------------------ Q59H64_HUMAN Q59H64_HUMAN ------------------------------------------------------------ B7Z7L6_HUMAN B7Z7L6_HUMAN KKKRKHRLWAAHCRKIQLKKG--------------------------------------- Q75MQ0_HUMAN Q75MQ0_HUMAN KKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCS Q96FI6_HUMAN Q96FI6_HUMAN KKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCS EZH2_MACFA EZH2_MACFA KKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCS B3KS30_HUMAN B3KS30_HUMAN KKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCS Q75MP9_HUMAN Q75MP9_HUMAN KKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCS B2RAQ1_HUMAN B2RAQ1_HUMAN KKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCS B7Z1D6_HUMAN B7Z1D6_HUMAN KKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCS EZH2_HUMAN EZH2_HUMAN KKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCS EZH2B_XENLA EZH2B_XENLA KKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCS EZH2A_XENLA EZH2A_XENLA KKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCS EZH2_XENTR EZH2_XENTR KKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCS Q4TFJ6_TETNG Q4TFJ6_TETNG ------------------------------------------------------------ EZH2_DANRE EZH2_DANRE KKKRKHRLWATHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVTAQNFCEKFCQCS Q504B3_DANRE Q504B3_DANRE KKKK-------------------------------------------------------- Q5TKR5_ORYLA Q5TKR5_ORYLA KKKRKHRLWATHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVTAQNFCEKFCQCS Q90WP4_TETNG Q90WP4_TETNG KKKRKHRLWATHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVTAQNFCEKFCQCS MATCH CONSENSUS KKKRKHRLWA?HCRKIQLKKD?SS??VYNYQPCDHP??PCDS?CPC???QNFCEKFCQC?

Q4S976_TETNG Q4S976_TETNG HECQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCMTCGAADHWDSKGVSCKNCSIQRGL EZH1_MOUSE EZH1_MOUSE PDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVVSCKNCSIQRGL EZH1_BOVIN EZH1_BOVIN PDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVVSCKNCSIQRGL EZH1_HUMAN EZH1_HUMAN PDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVVSCKNCSIQRGL EZH1_PONAB EZH1_PONAB PDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVVSCKNCSIQRGL B5DFE2_RAT B5DFE2_RAT SECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGS Q6AXH7_MOUSE Q6AXH7_MOUSE SECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGS Q571L5_MOUSE Q571L5_MOUSE SECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGS Q3TZH6_MOUSE Q3TZH6_MOUSE SECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGS EZH2_MOUSE EZH2_MOUSE SECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGS Q99L74_MOUSE Q99L74_MOUSE SECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGS Q3U575_MOUSE Q3U575_MOUSE ------------------------------------------------------------ Q59H64_HUMAN Q59H64_HUMAN ------------------------------------------------------------ B7Z7L6_HUMAN B7Z7L6_HUMAN ---QNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGS Q75MQ0_HUMAN Q75MQ0_HUMAN SECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGS Q96FI6_HUMAN Q96FI6_HUMAN SECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGS EZH2_MACFA EZH2_MACFA SECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGS B3KS30_HUMAN B3KS30_HUMAN SECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGS Q75MP9_HUMAN Q75MP9_HUMAN SECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGS B2RAQ1_HUMAN B2RAQ1_HUMAN SECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGS B7Z1D6_HUMAN B7Z1D6_HUMAN SECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGS EZH2_HUMAN EZH2_HUMAN SECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGS EZH2B_XENLA EZH2B_XENLA SDCQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGS EZH2A_XENLA EZH2A_XENLA SECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGS EZH2_XENTR EZH2_XENTR SECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGS Q4TFJ6_TETNG Q4TFJ6_TETNG ------------------------------------------------------------ EZH2_DANRE EZH2_DANRE SECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAAEHWDSKNVSCKNCSIQRGA Q504B3_DANRE Q504B3_DANRE ------------------------------------------------------------ Q5TKR5_ORYLA Q5TKR5_ORYLA SECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGA Q90WP4_TETNG Q90WP4_TETNG SECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGA MATCH CONSENSUS ??CQNRFPGCRCK?QCNTKQCPCYLAVRECDPDLCLTCGA??HWD?K?VSCKNCSIQRG?

Q4S976_TETNG Q4S976_TETNG KKHLLLAPSDVAGWGTFIKEPVQKNEFISEYCGELISQDEADRRGRIYDKYMSSFLFNLN EZH1_MOUSE EZH1_MOUSE KKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLN EZH1_BOVIN EZH1_BOVIN KKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLN EZH1_HUMAN EZH1_HUMAN KKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLN EZH1_PONAB EZH1_PONAB KKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLN B5DFE2_RAT B5DFE2_RAT KKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLN Q6AXH7_MOUSE Q6AXH7_MOUSE KKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLN Q571L5_MOUSE Q571L5_MOUSE KKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLN Q3TZH6_MOUSE Q3TZH6_MOUSE KKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLN EZH2_MOUSE EZH2_MOUSE KKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEDDRRGKVYDKYMCSFLFNLN Q99L74_MOUSE Q99L74_MOUSE KKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLN Q3U575_MOUSE Q3U575_MOUSE ------------------------------------------------------------ Q59H64_HUMAN Q59H64_HUMAN -----LLPRN-------------------------------------------------- B7Z7L6_HUMAN B7Z7L6_HUMAN KKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLN Q75MQ0_HUMAN Q75MQ0_HUMAN KKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLN Q96FI6_HUMAN Q96FI6_HUMAN KKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLN EZH2_MACFA EZH2_MACFA KKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLN B3KS30_HUMAN B3KS30_HUMAN KKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLN Q75MP9_HUMAN Q75MP9_HUMAN KKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLN B2RAQ1_HUMAN B2RAQ1_HUMAN KKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLN B7Z1D6_HUMAN B7Z1D6_HUMAN KKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLN EZH2_HUMAN EZH2_HUMAN KKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLN EZH2B_XENLA EZH2B_XENLA KKHLLLAPSDVAGWGIYIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLN EZH2A_XENLA EZH2A_XENLA KKHLLLAPSDVAGWGIFINDTVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLN EZH2_XENTR EZH2_XENTR KKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLN Q4TFJ6_TETNG Q4TFJ6_TETNG ------------------------------------------------------------ EZH2_DANRE EZH2_DANRE KKHLLLAPSDVAGWGIFIKEPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLN Q504B3_DANRE Q504B3_DANRE ------------------------------------------------------------ Q5TKR5_ORYLA Q5TKR5_ORYLA KKHLLLAPSDVAGWGIFIKEPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLN Q90WP4_TETNG Q90WP4_TETNG KKHLLLAPSDVAGWGIFIKEPVQKNDFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLN MATCH CONSENSUS KKHLLLAPSDVAGWG?FIK??VQKNEFISEYCGE?ISQDEADRRGKVYDKYM?SFLFNLN

Q4S976_TETNG Q4S976_TETNG NGNNHYYTLCLSVDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAILQ EZH1_MOUSE EZH1_MOUSE N------------DFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQA EZH1_BOVIN EZH1_BOVIN N------------DFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQA EZH1_HUMAN EZH1_HUMAN N------------DFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQA EZH1_PONAB EZH1_PONAB N------------DFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQA B5DFE2_RAT B5DFE2_RAT N------------DFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQT Q6AXH7_MOUSE Q6AXH7_MOUSE N------------DFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQT Q571L5_MOUSE Q571L5_MOUSE N------------DFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQT Q3TZH6_MOUSE Q3TZH6_MOUSE N------------DFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQT EZH2_MOUSE EZH2_MOUSE N------------DFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQT Q99L74_MOUSE Q99L74_MOUSE N------------DFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQT Q3U575_MOUSE Q3U575_MOUSE ------------------------------------------------------------ Q59H64_HUMAN Q59H64_HUMAN ------------------------------------------------------------ B7Z7L6_HUMAN B7Z7L6_HUMAN N------------DFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQT Q75MQ0_HUMAN Q75MQ0_HUMAN N------------DFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQT Q96FI6_HUMAN Q96FI6_HUMAN N------------DFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQT EZH2_MACFA EZH2_MACFA N------------DFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQT B3KS30_HUMAN B3KS30_HUMAN N------------DFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQT Q75MP9_HUMAN Q75MP9_HUMAN N------------DFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQT B2RAQ1_HUMAN B2RAQ1_HUMAN N------------DFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQT B7Z1D6_HUMAN B7Z1D6_HUMAN N------------DFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQT EZH2_HUMAN EZH2_HUMAN N------------DFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQT EZH2B_XENLA EZH2B_XENLA N------------DFVVDATRKGNKIRFANHSLNPNCYAKVMMVNGDHRIGIFAKRAIQT EZH2A_XENLA EZH2A_XENLA N------------DFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQT EZH2_XENTR EZH2_XENTR N------------DFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQT Q4TFJ6_TETNG Q4TFJ6_TETNG ------------------------------------------------------------ EZH2_DANRE EZH2_DANRE N------------DFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQT Q504B3_DANRE Q504B3_DANRE ------------------------------------------------------------ Q5TKR5_ORYLA Q5TKR5_ORYLA N------------DFVVDATRKGNKIRFANHSVNPNCYAKVMMVSGDHRIGIFAKRAIQT Q90WP4_TETNG Q90WP4_TETNG N------------DFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQT MATCH CONSENSUS N????????????DFVVDATRKGNKIRFANHSVNPNCYAKV?MVNGDHRIGIFAKRAIQ?

Q4S976_TETNG Q4S976_TETNG GEELFFDYRYSQADALKYVGIEREVDM- EZH1_MOUSE EZH1_MOUSE GEELFFDYRYSQADALKYVGIERETDVF EZH1_BOVIN EZH1_BOVIN GEELFFDYRYSQADALKYVGIERETDVL EZH1_HUMAN EZH1_HUMAN GEELFFDYRYSQADALKYVGIERETDVL EZH1_PONAB EZH1_PONAB GEELFLDYRYSQADALKYVGIERETDVL B5DFE2_RAT B5DFE2_RAT GEELFFDYRYSQADALKYVGIEREMEIP Q6AXH7_MOUSE Q6AXH7_MOUSE GEELFFDYRYSQADALKYVGIEREMEIP Q571L5_MOUSE Q571L5_MOUSE GEELFFDYRYSQADALKYVGIEREMEIP Q3TZH6_MOUSE Q3TZH6_MOUSE GEELFFDYRYSQADALKYVGIEREMEIP EZH2_MOUSE EZH2_MOUSE GEELFFDYRYSQADALKYVGIEREMEIP Q99L74_MOUSE Q99L74_MOUSE GEELFFDYRYSQADALKYVGIEREMEIP Q3U575_MOUSE Q3U575_MOUSE ---------------------------- Q59H64_HUMAN Q59H64_HUMAN ---------------------------- B7Z7L6_HUMAN B7Z7L6_HUMAN GEELFFDYRYSQADALKYVGIEREMEIP Q75MQ0_HUMAN Q75MQ0_HUMAN GEELFFDYRYSQADALKYVGIEREMEIP Q96FI6_HUMAN Q96FI6_HUMAN GEELFFDYRYSQADALKYVGIEREMEIP EZH2_MACFA EZH2_MACFA GEELFFDYRYSQADALKYVGIEREMEIP B3KS30_HUMAN B3KS30_HUMAN GEELFFDYRYSQADALKYVGIEREMEIP Q75MP9_HUMAN Q75MP9_HUMAN GEELFFDYRYSQADALKYVGIEREMEIP B2RAQ1_HUMAN B2RAQ1_HUMAN GEELFFDYRYSQADALKYVGIEREMEIP B7Z1D6_HUMAN B7Z1D6_HUMAN GEELFFDYRYSQADALKYVGIEREMEIP EZH2_HUMAN EZH2_HUMAN GEELFFDYRYSQADALKYVGIEREMEIP EZH2B_XENLA EZH2B_XENLA GEELFFDYRYSQADALKYVGIEREMEIP EZH2A_XENLA EZH2A_XENLA GEELFFDYRYSQADALKYVGIEREMEIP EZH2_XENTR EZH2_XENTR GEELFFDYRYSQADALKYVGIEREMEIP Q4TFJ6_TETNG Q4TFJ6_TETNG ---------------------------- EZH2_DANRE EZH2_DANRE GEELFFDYRYSQADALKYVGIEREMEIP Q504B3_DANRE Q504B3_DANRE ---------------------------- Q5TKR5_ORYLA Q5TKR5_ORYLA GEELFFDYRYSQADALKYVGIEREMEIA Q90WP4_TETNG Q90WP4_TETNG GEELFFDYRYSQADARKYVGIEREMEIA MATCH CONSENSUS GEELFFDYRYSQADALKYVGIERE????


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