Alignment of the gene Family HBG002609 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
Q9YH35_TETFL Q9YH35_TETFL -MGSSYGFSRGNVILMLLLLLLDGVRGLYFSQSEYIETVYVGQPAGTPVLQVHALRDNVS P79726_DANRE P79726_DANRE -----MGSTRGIVWGVLLLLLSEGLLGLYFPQRLYTENIYVGQQQGSPLLQVISMREFPT A8E7C7_DANRE A8E7C7_DANRE ------------------------SFGLYFPQRLYTENIYVGQQQGSPLLQVISMREFPT O42362_DANRE O42362_DANRE -----MGSTRGIVWGVLLLLLSEGSFGLYFPQRLYTENIYVGQQQGSPLLQVISMREFPT A8E7C6_DANRE A8E7C6_DANRE -----MGSTRGIVWGVLLLLLSEGSFGLYFPQRLYTENIYVGQQQGSPLLQVISMREFPT B7ZRI5_XENLA B7ZRI5_XENLA --------MAPAEWALCFLCLFQVTSGLYFLRKDYYENVYVDQPAGTLLLQVHVMKDSPS B7ZRI3_XENLA B7ZRI3_XENLA --------MAPAEWALCFLCLFQVTSGLYFLRKDYYENVYVDQPAGTLLLQVHVMKDSPS Q9DGL0_XENLA Q9DGL0_XENLA --------MAPAEWALCFLCLFQVTSGLYFLRKDYYENVYVDQPAGTLLLQVHVMKDSPS Q90601_CHICK Q90601_CHICK --------MRSVRGAAGLLLLCGASFGLYFPRKEYSENVYIDQPAGAPLLRIHALRDSHG Q9PSD4_CHICK Q9PSD4_CHICK --------MRSMRGAAGLLLLCGASFGLYFPRKEYSENVYIDQPAGAPLLRIHALRDSHG Q9UMQ4_HUMAN Q9UMQ4_HUMAN -----------------------VALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPE RET_HUMAN RET_HUMAN AKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPE Q9BTB0_HUMAN Q9BTB0_HUMAN AKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPE A8K6Z2_HUMAN A8K6Z2_HUMAN AKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPE B4DGX8_HUMAN B4DGX8_HUMAN ------------------------------------------------------------ RET_MOUSE RET_MOUSE AKATSGAAGLGLKLILLLPLLGEAPLGLYFSRDAYWERLYVDQPAGTPLLYVHALRDAPG Q9EPA1_RAT Q9EPA1_RAT AKARSGAAGLGLKLFLLLPLLGEAPLGLCFSRDAYWERLYVDQPAGTPLLYVHALRDAPG Q9EPC3_RAT Q9EPC3_RAT AKARSGAAGLGLKLFLLLPLLGEAPLGLCFSRDAYWERLYVDQPAGTPLLYVHALRDAPG MATCH CONSENSUS ????????????????????L?????GLYF????Y?E??YV?Q??G??LL?V????????

Q9YH35_TETFL Q9YH35_TETFL QLPHFYLCWV---KFLRRPAYISWFSLDVNTGVLYLNKTLEESDFASVYQSNQ--AVKKL P79726_DANRE P79726_DANRE ERPYFFLCSH-------RDAFTSWFHIDEAS-VLYLNKTLEWSDFSSLRSGSVRSP-KDL A8E7C7_DANRE A8E7C7_DANRE ERPYFFLCSH-------RDAFTSWFHIDEASGVLYLNKTLEWSDFSSLRSGSVRSP-KDL O42362_DANRE O42362_DANRE ERPYFFLCSH-------RDAFTSWFHIDEASGVLYLNKTLEWSDFSSLRSGSVRSP-KDL A8E7C6_DANRE A8E7C6_DANRE ERPYFFLCSH-------RDAFTSWFHIDEASGVLYLNKTLEWSDFSSLRSGSVRSP-KDL B7ZRI5_XENLA B7ZRI5_XENLA EKPHFRLCPT---INFSRNSFYHWFRIDEHTGNLYLNRSLDRSDYEVFSQGSQ-SAIQKI B7ZRI3_XENLA B7ZRI3_XENLA EKPHFRLCPT---INFSRNSFYHWFRIDEHTGNLYLNRSLDRSDYEVFSQGSQ-SAIQKI Q9DGL0_XENLA Q9DGL0_XENLA EKPHFRLCPT---INFSRNSFYHWFRIDEHTGNLYLNRSLDRSDYEVFSQGSQ-SAIQKI Q90601_CHICK Q90601_CHICK KQPTF-ICARSLIISRARSHENHWFQIREKMGLLYLSKSLDREDFNMLSVGNW-MPLSKV Q9PSD4_CHICK Q9PSD4_CHICK ETAHFHLCQNLI-ISRARSHESHWFQIREKMGLLYLSKSLDREDFNMLSVGNW-MPLSKV Q9UMQ4_HUMAN Q9UMQ4_HUMAN EVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTV RET_HUMAN RET_HUMAN EVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTV Q9BTB0_HUMAN Q9BTB0_HUMAN EVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTV A8K6Z2_HUMAN A8K6Z2_HUMAN EVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTV B4DGX8_HUMAN B4DGX8_HUMAN ------------------------------------------------------------ RET_MOUSE RET_MOUSE EVPSFRLGQHLYGVYRTRLHENDWIRINETTGLLYLNQSLDHSSWEQLSIRNGGFPLLTI Q9EPA1_RAT Q9EPA1_RAT EVPSFRLGQYLYGVYRTRLHENDWIHIDAGTGLLYLNQSLDHSSWEQLSIRNGGFPLLTV Q9EPC3_RAT Q9EPC3_RAT EVPSFRLGQYLYGVYRTRLHENDWIHIDAGTGLLYLNQSLDHSSWEQLSIRNGGFPLLTV MATCH CONSENSUS E?P?F?L??????????R?????W??I????G?LYLN??L??S?????????????????

Q9YH35_TETFL Q9YH35_TETFL SLHVMASPGFTKKPLCNSRNYPRITLDFVNALMPQCGETDLKELCFPRKDTSNPHITENR P79726_DANRE P79726_DANRE TLKVGVSSTPPMKVMCTILPTVEVKLSFINDTAPSCGQVELSTLCFPEKISN-PHITENR A8E7C7_DANRE A8E7C7_DANRE TLKVGVSSTPPMKVMCTILPTVEVKLSFINDTAPSCGQVELSTLCFPEKISN-PHITENR O42362_DANRE O42362_DANRE TLKVGVSSTPPMKVMCTILPTVEVKLSFINDTAPSCGQVELSTLCFPEKISN-PHITENR A8E7C6_DANRE A8E7C6_DANRE TLKVGVSSTPPMKVMCTILPTVEVKLSFINDTAPSCGQVELSTLCFPEKISN-PHITENR B7ZRI5_XENLA B7ZRI5_XENLA TLKVSTKPHPFLDKDCNNAPLTWVHLNFINLTSSICFSLKPKDLCFNDKDLS-FHIKENK B7ZRI3_XENLA B7ZRI3_XENLA TLKVSTKPHPFLDKDCNNAPLTWVHLNFINLTSSICFSLKPKDLCFNDKDLS-FHIKENK Q9DGL0_XENLA Q9DGL0_XENLA TLKVSTKPHPFLDKDCNNAPLTWVHLNFINLTSSICFSLKPKDLCFNDKDLS-FHIKENK Q90601_CHICK Q90601_CHICK MLYVFLSSHPFQEKECDSATRTTVVLSLINATAPACSSLSARQLCFTEMDLS-FHIKENK Q9PSD4_CHICK Q9PSD4_CHICK MLYVFLSSHPFQEKECDSATRTTVVLSLINATAPACSSLSARQLCFTEMDLS-FHIKENK Q9UMQ4_HUMAN Q9UMQ4_HUMAN YLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPS-FRIRENR RET_HUMAN RET_HUMAN YLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPS-FRIRENR Q9BTB0_HUMAN Q9BTB0_HUMAN YLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPS-FRIRENR A8K6Z2_HUMAN A8K6Z2_HUMAN YLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPS-FRIRENR B4DGX8_HUMAN B4DGX8_HUMAN ------------------------------------------------------------ RET_MOUSE RET_MOUSE FLQVFLGSTAQREGECHWPGCTRVYFSFINDTFPNCSSFKAQDLCIPETAVS-FRVRENR Q9EPA1_RAT Q9EPA1_RAT FLQVFLGSTAQREGECHWPGCARVYFSFINDTFPNCSSFKARDLCTPETGVS-FRIRENR Q9EPC3_RAT Q9EPC3_RAT FLQVFLGSTAQREGECHWPGCARVYFSFINDTFPNCSSFKARDLCTPETGVS-FRIRENR MATCH CONSENSUS ?L?V???????????C???????V???F?N?????C???????LC??????????I?EN?

Q9YH35_TETFL Q9YH35_TETFL FPGGLRQLRRLSWLNVCPNYTISYSVETESPAPFAVNENTTELVVTAPLDREESESYR-L P79726_DANRE P79726_DANRE EPGALPTAR-FTHMRICPNYTISYGVVAGSSVPFAVDDSTSELVVTAQVDREEKEVYH-L A8E7C7_DANRE A8E7C7_DANRE EPGALRQLRRFTHMSICPNYTISYGVVAGSSVPFAVDDSTSELVVTAQVDREEKEVYH-L O42362_DANRE O42362_DANRE EPGALRHVRRFTHMSICPNYTISYGVVAGSSVPFAVDDSTSELVVTAQVDREEKEVYH-L A8E7C6_DANRE A8E7C6_DANRE EPGALRQLRRFTHMSICPNYTISYGVVAGSSVPFAVDDSTSELVVTAQVDREEKEVYH-L B7ZRI5_XENLA B7ZRI5_XENLA PPGKFYKFHPRPIVQSCPNVSVSYMLISDHSYPFRFNPNTSEVSLTHSVDREERENYD-L B7ZRI3_XENLA B7ZRI3_XENLA PPGKFYKFHPRPIVQSCPNVSVSYMLISDHSYPFRFNPNTSEVSLTHSVDREERENYD-L Q9DGL0_XENLA Q9DGL0_XENLA PPGKFYKFHPRPIVQSCPNVSVSYMLISDHSYPFRFNPNTSEVSLTHSVDREERENYD-L Q90601_CHICK Q90601_CHICK PPGTFHQLQLPSVHHLCQNLSITYKLLAAEGLPFRYNENTTGVSVTQRLDREERERYE-L Q9PSD4_CHICK Q9PSD4_CHICK PPGTFHQLQLPSVHHLCQNLSITDKMLAAEGLNFRYNENTTGVSVTQRLDREERERYELL Q9UMQ4_HUMAN Q9UMQ4_HUMAN PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYE-L RET_HUMAN RET_HUMAN PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYE-L Q9BTB0_HUMAN Q9BTB0_HUMAN PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYE-L A8K6Z2_HUMAN A8K6Z2_HUMAN PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYE-L B4DGX8_HUMAN B4DGX8_HUMAN ------------------------------------------------------------ RET_MOUSE RET_MOUSE PPGTFYHFHMLPVQFLCPNISVKYSLLGGDSLPFRCDPDCLEVSTRWALDRELREKYV-L Q9EPA1_RAT Q9EPA1_RAT PPGTFYQFRMLPVQFLCPNISVKYKLLEGDGLPFRCDPDCLEVSTRWALDRELQEKYV-L Q9EPC3_RAT Q9EPC3_RAT PPGTFYQFRMLPVQFLCPNISVKYKLLEGDGLPFRCDPDCLEVSTRWALDRELQEKYV-L MATCH CONSENSUS ?PG?????????????CPN????Y????????PF???????E???????DRE??E?Y??L

Q9YH35_TETFL Q9YH35_TETFL LLVCTVR-TEAVITKVETSLDVFVD-DEDDNAPYMN-GTDTSDIVISFNRTAGGSFGTLS P79726_DANRE P79726_DANRE DIVCMVRTERNLEEVGFRSLHVNIY-DEDDNSPYVN-GTDTEDVLVEFDRREGTVLGRLF A8E7C7_DANRE A8E7C7_DANRE DIVCMVR-TERNLEEVFRSLHVNIY-DEDDNSPYVN-GTDTEDVLVEFDRSEGTVFGTLF O42362_DANRE O42362_DANRE DIVCMVR-TERNLEEVFRSLHVNIY-DEDDNSPYVN-GTDTEDVLVEFDRSEGTVFGTLF A8E7C6_DANRE A8E7C6_DANRE DIVCMVR-TERNLEEVFRSLHVNIY-DEDDNSPYVN-GTDTEDVLVEFDRSEGTVFGTLF B7ZRI5_XENLA B7ZRI5_XENLA VAKCLLR-DASSEVEVEQSFQIKVD-DEDDTAPFLPNGTDTAHVVVDFKRKNGTVLGMLT B7ZRI3_XENLA B7ZRI3_XENLA VAKCLLR-DASSEVEVEQSFQIKVD-DEDDTAPFLPNGTDTAHVVVDFKRKNGTVLGMLT Q9DGL0_XENLA Q9DGL0_XENLA VAKCLLR-DASSEVEVEQSFQIKVD-DEDDTAPFLPNGTDTAHVVVDFKRKNGTVLGMLT Q90601_CHICK Q90601_CHICK IAKCTVR-EGFREMEVEVPFLVNVL-DEDDSPPFLPNGTDTADAVVEFNRKEGTVLATLT Q9PSD4_CHICK Q9PSD4_CHICK IAKCTVR-EGFREMEVEVPSLVNVL-DEDDSPPFLPNGTDTADAVVEFNRKEGTVLATLT Q9UMQ4_HUMAN Q9UMQ4_HUMAN VAVCTVH-AGAREEVVMVPFPVTVY-DEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLR RET_HUMAN RET_HUMAN VAVCTVH-AGAREEVVMVPFPVTVY-DEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLR Q9BTB0_HUMAN Q9BTB0_HUMAN VAVCTVH-AGAREEVVMVPFPVTVY-DEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLR A8K6Z2_HUMAN A8K6Z2_HUMAN VAVCTVH-AGAREEVVMVPFPVTVY-DEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLR B4DGX8_HUMAN B4DGX8_HUMAN ----------------MVPFPVTVY-DEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLR RET_MOUSE RET_MOUSE EALCIVAGPGANKETVTLSFPVTVY-DEDDSAPTFSGGVGTASAVVEFKRKEGTVVATLQ Q9EPA1_RAT Q9EPA1_RAT EAECAVAGPGANKEKVAVSFPVTVYDDEDDSPPTFSGGVGTASAVVEFKRKEGTVVATLQ Q9EPC3_RAT Q9EPC3_RAT EAECAVAGPGANKEKVAVSFPVTVYDDEDDSPPTFSGGVGTASAVVEFKRKEGTVVATLQ MATCH . : : ****..* . *..* ::.*.* . .. * CONSENSUS ???C???????????V?????V????DEDD??P????G?DT????V?F?R???TV???L?

Q9YH35_TETFL Q9YH35_TETFL VFDRDLTPI--IDRTHNKYVGTLLNIDPWVKETFDIKGTFSEKKAAQGG--IRETVHDYH P79726_DANRE P79726_DANRE VYDRDTTPVYPTNQVQNKLVGTLMTNDSWIKNNFAIEHKFREEKAIFGN--VRGTVHEYK A8E7C7_DANRE A8E7C7_DANRE VYDRDTTPVYPTNQVQNKLVGTLMTNDSWIKNNFAIEHKFREEKAIFGN--VRGTVHEYK O42362_DANRE O42362_DANRE VYDRDTTPVYPTNQVQNKLVGTLMTNDSWIKNNFAIEHKFREEKAIFGN--VRGTVHEYK A8E7C6_DANRE A8E7C6_DANRE VYDRDTTPVYPTNQVQNKLVGTLMTNDSWIKNNFAIEHKFREEKAIFGN--VRGTVHEYK B7ZRI5_XENLA B7ZRI5_XENLA VWDADSTPVYPADVSRKKYTKTIVSKDRFILENFRVEHSFKEVKFRPKGNLIRGTLHEYR B7ZRI3_XENLA B7ZRI3_XENLA VWDADSTPVYPADVSRKKYTKTIVSKDRFILENFRVEHSFKEVKFQPKGNLIRGTLHEYR Q9DGL0_XENLA Q9DGL0_XENLA VWDADSTPVYPADVSRKKYTKTIVSKDRFILENFRVEHSFKEVKFQPKGNLIRGTLHEYR Q90601_CHICK Q90601_CHICK VYDADTTPIYPLESSRKKYTGTIITDDPWINETFRVEHIFDEIHFSPNGSQERGTQHEYK Q9PSD4_CHICK Q9PSD4_CHICK VYDADTTPIYPLESSRKKYTGTIITDDPWINETFRVEHIFDEIHFSPNGSQVRGTQHEYK Q9UMQ4_HUMAN Q9UMQ4_HUMAN VFDADVVPA--SGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYR RET_HUMAN RET_HUMAN VFDADVVPA--SGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYR Q9BTB0_HUMAN Q9BTB0_HUMAN VFDADVVPA--SGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYR A8K6Z2_HUMAN A8K6Z2_HUMAN VFDADVVPA--SGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYR B4DGX8_HUMAN B4DGX8_HUMAN VFDADVVPA--SGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYR RET_MOUSE RET_MOUSE VFDADVVPA--SGELVRRYTNTLLSGDSWAQQTFRVEHSPIETLVQVNNNSVRATMHNYK Q9EPA1_RAT Q9EPA1_RAT VFDADVVPA--SGELVRRYTSTLLSGDSWAQQTFRVEHTPNETLVQSNNNSVRATMHNYR Q9EPC3_RAT Q9EPC3_RAT VFDADVVPA--SGELVRRYTSTLLSGDSWAQQTFRVEHTPNETLVQSNNNSVRATMHNYR MATCH *:* * .* .: . *:: * : :.* :: * . * * *:*: CONSENSUS V?D?D??P?????????????T????D?W????F??EH???E??????????R?T?H?Y?

Q9YH35_TETFL Q9YH35_TETFL LVLKRNLYVTENRTLQLDYLVNDTTYPGLE--GTVLLHFNVTILPVHIFFSNITHTFPLT P79726_DANRE P79726_DANRE LNLSQNLSVTEQRSFLLGYLVNDTTFPGPE--GTVLLHFNVTVLPVPIRFSNVTYSFTVS A8E7C7_DANRE A8E7C7_DANRE LKLSQNLSVTEQRSFLLGYLVNDTTFPGPE--GTVLLHFNVTVLPVPIRFSNVTYSFTVS O42362_DANRE O42362_DANRE LKLSQNLSVTEQRSFLLGYLVNDTTFPGPE--GTVLLHFNVTVLPVPIRFSNVTYSFTVS A8E7C6_DANRE A8E7C6_DANRE LKLSQNLSVTEQRSFLLGYLVNDTTFPGPE--GTVLLHFNVTVLPVPIRFSNVTYSFTVS B7ZRI5_XENLA B7ZRI5_XENLA LVLNKSIPIIRNGSLLVSVLVNDTEFHGPN--GDVMLYFNVTILSMEIRFPNISYQYTVN B7ZRI3_XENLA B7ZRI3_XENLA LVLNKSIPIIRNGSLLVSVLVNDTEFHGPN--GDVMLYFNVTILSMEIRFPNISYQYTVN Q9DGL0_XENLA Q9DGL0_XENLA LVLNKSIPIIRNGSLLVSVLVNDTEFHGPN--GDVMLYFNVTILSMEIRFPNISYQYTVN Q90601_CHICK Q90601_CHICK LVLNKSISVTEHRSFQLDVLVNDTEFNGPE--KSVMLHFNVSILPVSIQFPNTTYRFTVN Q9PSD4_CHICK Q9PSD4_CHICK LVLNKSISVTEHRSFQLDVLVTDTEFNGPE--KSVMLHFNVSILPVSIQFPNTTYRFTVN Q9UMQ4_HUMAN Q9UMQ4_HUMAN LVLNRNLSISENRTMQLAVLVNDSDFQGPGA-GVLLLHFNVSVLPVSLHLPS-TYSLSVS RET_HUMAN RET_HUMAN LVLNRNLSISENRTMQLAVLVNDSDFQGPGA-GVLLLHFNVSVLPVSLHLPS-TYSLSVS Q9BTB0_HUMAN Q9BTB0_HUMAN LVLNRNLSISENRTMQLAVLVNDSDFQGPGA-GVLLLHFNVSVLPVSLHLPS-TYSLSVS A8K6Z2_HUMAN A8K6Z2_HUMAN LVLNRNLSISENRTMQLAVLVNDSDFQGPGA-GVLLLHFNVSVLPVSLHLPS-TYSLSVS B4DGX8_HUMAN B4DGX8_HUMAN LVLNRNLSISENRTMQLAVLVNDSDFQGPGA-GVLLLHFNVSVLPVSLHLPS-TYSLSVS RET_MOUSE RET_MOUSE LILNRSLSISESRVLQLAVLVNDSDFQGPGAGGILVLHFNVSVLPVTLNLPR-AYSFPVN Q9EPA1_RAT Q9EPA1_RAT LVLNRSLSISESRVLQLVVLVNDSDFQGPGS-GFLFLHFNVSVLPVTLNLPM-AYSFPVN Q9EPC3_RAT Q9EPC3_RAT LVLNRSLSISESRVLQLVVLVNDSDFQGPGS-GFLFLHFNVSVLPVTLNLPM-AYSFPVN MATCH * *.:.: : . : : **.*: : * :.*:***::*.: : :. :: .:. CONSENSUS L?L???????E?R???L??LVND??F?GP???G???LHFNV??LPV????????Y???V?

Q9YH35_TETFL Q9YH35_TETFL RRASSYAQVGKVCVENCRQFDGFRIAYRLELPDKNVSADVLSCHSAVSIAQAPD-EMWGL P79726_DANRE P79726_DANRE QKATTYSQIGKVCVENCQKFKGIDVTYQLEIVDRNITAEAQSCYWAVSLGTKPEWIIQGV A8E7C7_DANRE A8E7C7_DANRE QKATTYSQIGKVCVENCQKFKGIDVTYQLEIVDRNITAEAQSCYWAVSLAQNPN-DNTGV O42362_DANRE O42362_DANRE QKATTYSQIGKVCVENCQKFKGIDVTYQLEIVDRNITAEAQSCYWAVSLAQNPN-DNTGV A8E7C6_DANRE A8E7C6_DANRE QKATTYSQIGKVCVENCQKFKGIDVTYQLEIVDRNITAEAQSCYWAVSLAQNPN-DNTGV B7ZRI5_XENLA B7ZRI5_XENLA RNADRYAQIGKICIENCKLVEGVNINYRLQTEN-N-------TH-AFAIIQGRE-STFAT B7ZRI3_XENLA B7ZRI3_XENLA RNADRYAQIGKICIENCKLVEGVNINYRLQTEN-N-------TH-AFAIIQGRE-STFAT Q9DGL0_XENLA Q9DGL0_XENLA RNADRYAQIGKICIENCKLVEGVNINYRLQTEN-N-------TH-AFAIIQGRE-STFAT Q90601_CHICK Q90601_CHICK RNAQRFAQIGKICIENCMKFRGVNITYKLLSPNVS-------CY-AVGILQGRE-DKYGS Q9PSD4_CHICK Q9PSD4_CHICK RNAQRFAQIGKICIENCMKFRGVNITYKLLSPNVS-------CY-AVGILQGRE-DKYGS Q9UMQ4_HUMAN Q9UMQ4_HUMAN RRARRFAQIGKVCVENCQAFSGINVQYKLHSSGAN-------CS-TLGVVTSAE-DTSGI RET_HUMAN RET_HUMAN RRARRFAQIGKVCVENCQAFSGINVQYKLHSSGAN-------CS-TLGVVTSAE-DTSGI Q9BTB0_HUMAN Q9BTB0_HUMAN RRARRFAQIGKVCVENCQAFSGINVQYKLHSSGAN-------CS-TLGVVTSAE-DTSGI A8K6Z2_HUMAN A8K6Z2_HUMAN RRARRFAQIGKVCVENCQAFSGINVQYKLHSSGAN-------CS-TLGVVTSAE-DTSGI B4DGX8_HUMAN B4DGX8_HUMAN RRARRFAQIGKVCVENCQAFSGINVQYKLHSSGAN-------CS-TLGVVTSAE-DTSGI RET_MOUSE RET_MOUSE KRARRYAQIGKVCVENCQEFSGVSIQYKLQPSSIN-------CT-ALGVVTSPE-DTSGT Q9EPA1_RAT Q9EPA1_RAT RRARRYAQIGKVCVENCQEFSGVSIQYKLQPSSTN-------CS-ALGVVTSTE-DTSGT Q9EPC3_RAT Q9EPC3_RAT RRARRYAQIGKVCVENCQEFSGVSIQYKLQPSSTN-------CS-ALGVVTSTE-DTSGT MATCH :.* ::*:**:*:*** . *. : *:* . . :..: : . CONSENSUS ??A????QIGK?C?ENC??F?G????Y?L?????N???????C???????????????G?

Q9YH35_TETFL Q9YH35_TETFL LYVNDTEELRRPECQDLQYLVVVKEQHTQMETSVQIQIILD----NEVGQESQPLLSCAE P79726_DANRE P79726_DANRE LYVNDTKVLRRPECQELEYVVIAQEQQNKLQAKTQLTVSFQGEADSLRTDVANDFQHCAE A8E7C7_DANRE A8E7C7_DANRE LYVNDTKVLRRPECQELEYVVIAQEQQNKLQAKTQLTVSFQGEADSLKTDEPRFPA-CAE O42362_DANRE O42362_DANRE LYVNDTKVLRRPECQELEYVVIAQEQQNKLQAKTQLTVSFQGEADSLRTDEPRFPA-CAE A8E7C6_DANRE A8E7C6_DANRE LYVNDTKVLRRPECQELEYVVIAQEQQNKLQAKTQLTVSFQGEADSLKTDEPRFPA-CAE B7ZRI5_XENLA B7ZRI5_XENLA LIVNDSDALATHESKEIVCTVFATNKHLKEPVRTQIIIVLEG---TPMKDEDNCPHSCSE B7ZRI3_XENLA B7ZRI3_XENLA LIVNDSDALATHESKEIVCTVFATNKHLKEPVRTQIIIVLEG---TPMKDEDNCPHSCSE Q9DGL0_XENLA Q9DGL0_XENLA LIVNDSDALATHESKEIVCTVFATNKHLKEPVRTQIIIVLEG---TPMKDEDNCPHSCSE Q90601_CHICK Q90601_CHICK LYVNDSSVLLRPECKEIQYTVQATDKQSRKHTKTLFTVVLEG---TLFKKEEDCPDSCAM Q9PSD4_CHICK Q9PSD4_CHICK LYVNDSSVLLRPECKEIQYTVHATDKQSRKHTKTLFTVVLEG---PLFKKEEDCPDSCAM Q9UMQ4_HUMAN Q9UMQ4_HUMAN LFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEG---SYVAEEAGCPLSCAV RET_HUMAN RET_HUMAN LFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEG---SYVAEEAGCPLSCAV Q9BTB0_HUMAN Q9BTB0_HUMAN LFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEG---SYVAEEAGCPLSCAV A8K6Z2_HUMAN A8K6Z2_HUMAN LFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEG---SYVAEEAGCPLSCAV B4DGX8_HUMAN B4DGX8_HUMAN LFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEG---SYVAEEAGCPLSCAV RET_MOUSE RET_MOUSE LFVNDTEALRRPECTKLQYTVVATDRQTRRQTQASLVVTVEG---TSITEEVGCPKSCAV Q9EPA1_RAT Q9EPA1_RAT LYVNDTEALRRPECTELQYTVVATDRQTRRQTQASLVVTVEG---TYIAEEVGCPKSCAV Q9EPC3_RAT Q9EPC3_RAT LYVNDTEALRRPECTELQYTVVATDRQTRRQTQASLVVTVEG---TYIAEEVGCPKSCAV MATCH * ***:. * :. .: * . ::: . . : : .: . *: CONSENSUS L?VND???L?RP?C?E??Y?V?A??????????????????G????????E???P??CA?

Q9YH35_TETFL Q9YH35_TETFL NRRRGDCESARGLGTTTGRCQWRQGSDKGISKNYSTCSPDLRTCPD-SVCDAVESKDASI P79726_DANRE P79726_DANRE KRQRGDCEATRGLGAPTGRCQWRQGRDKGISKRYSTCSPNLG-CPD-GYCDAIESKNISI A8E7C7_DANRE A8E7C7_DANRE KRQRGDCEATRGLGAPTGRCQWRQGRDKGISKRYSTCSPNLGTCPD-GYCDAIESKNISI O42362_DANRE O42362_DANRE KRQRGDCEATRGLGAPTGRCQWRQGRDKGISKRYSTCSPNLGTCPD-GYCDAIESKNISI A8E7C6_DANRE A8E7C6_DANRE KRQRGDCEATRGLGAPTGRCQWRQGRDKGISKRYSTCSPNLGTCPD-GYCDAIESKNISI B7ZRI5_XENLA B7ZRI5_XENLA SRQKSECEECGGLGSLTGRCQWRQGHGEGITTNYSTCTPSLLTCPD-GICDAVEMNDSAI B7ZRI3_XENLA B7ZRI3_XENLA SRQKSECEECGGLGSLTGRCQWRQGHGEGITTNYSTCTPSLLTCPD-GICDAVEMNDSAI Q9DGL0_XENLA Q9DGL0_XENLA SRQKSECEECGGLGSLTGRCQWRQGHGEGITTNYSTCTPSLLTCPD-GICDAVEMNDSAI Q90601_CHICK Q90601_CHICK SKHLAECEECGGLGVLTGRCQWRQGSGKGITTNYSTCTPSIKNLLQMATCDIVESKDPAI Q9PSD4_CHICK Q9PSD4_CHICK SKHLAECEECGGLGVLTGRCQWRQGSGKGITTNYSTCSPSTKTCPD-GTCDVVESKDPAI Q9UMQ4_HUMAN Q9UMQ4_HUMAN SKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPD-GHCDVVETQDINI RET_HUMAN RET_HUMAN SKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPD-GHCDVVETQDINI Q9BTB0_HUMAN Q9BTB0_HUMAN SKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPD-GHCDVVETQDINI A8K6Z2_HUMAN A8K6Z2_HUMAN SKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPD-GHCDVVETQDINI B4DGX8_HUMAN B4DGX8_HUMAN SKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPD-GHCDVVETQDINI RET_MOUSE RET_MOUSE NKRRPECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTRTCPD-GHCDAVESRDANI Q9EPA1_RAT Q9EPA1_RAT NKRRPECEECGGLGSPTGRCEWRQGDGKGTTRNFSTCSPSTRTCPD-GHCDALESRDINI Q9EPC3_RAT Q9EPC3_RAT NKRRPECEECGGLGSPTGRCEWRQGDGKGTTRNFSTCSPSTRTCPD-GHCDALESRDINI MATCH .:: :** *** ****:**** .:* : .:***:*. : . ** :* .: * CONSENSUS ??????CE???GLG??TGRC?WRQG??KGI????STC?P???TCPD?G?CD??E?????I

Q9YH35_TETFL Q9YH35_TETFL CPQDCTKKTVIGGHEPGLRN-GIQAGHGTCYCY--SEKCFCEKEDIDETMCDDMCKTIIA P79726_DANRE P79726_DANRE CPQDCSSEAIIGGYERDLY--GIKAGHGTCYCF--EGKCFCERDEPEDDICNDMCKTVIA A8E7C7_DANRE A8E7C7_DANRE CPQDCSSEAIIGGYERDLY--GIKAGHGTCYCF--EGKCFCERDEPEDDICNDMCKTVIA O42362_DANRE O42362_DANRE CPQDCSSEAIIGGYERDLY--GIKAGHGTCYCF--EGKCFCERDEPEDDICNDMCKTVIA A8E7C6_DANRE A8E7C6_DANRE CPQDCSSEAIIGGYERDLY--GIKAGHGTCYCF--EGKCFCERDEPEDDICNDMCKTVIA B7ZRI5_XENLA B7ZRI5_XENLA CPQDCTEITIIGGHEKGRLK-GIKAGYGTCFCLL-PDKCFCEKNIVEGQLCDDTCKTVIA B7ZRI3_XENLA B7ZRI3_XENLA CPQDCTEITIIGGHEKGRLK-GIKAGYGTCFCLL-PDKCFCEKNIVEGQLCDDTCKTVIA Q9DGL0_XENLA Q9DGL0_XENLA CPQDCTEITIIGGHEKGRLK-GIKAGYGTCFCLL-PDKCFCEKNIVEGQLCDDTCKTVIA Q90601_CHICK Q90601_CHICK CPQDCTNGNIIGGHGKGTGNLGIKSGHGICYCFP-RQNCYCEKDDIKEQFCDEVCKTVIA Q9PSD4_CHICK Q9PSD4_CHICK CPQDCTNGNI-GGHGKGTGNLGIKSGHGICYCFP-RQNCYCEKDDIKEQFCDEVCKTVIA Q9UMQ4_HUMAN Q9UMQ4_HUMAN CPQDCLRGSIVGGHEPGEPR-GIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIA RET_HUMAN RET_HUMAN CPQDCLRGSIVGGHEPGEPR-GIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIA Q9BTB0_HUMAN Q9BTB0_HUMAN CPQDCLRGSIVGGHEPGEPR-GIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIA A8K6Z2_HUMAN A8K6Z2_HUMAN CPQDCLRGSIVGGHEPGEPR-GIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIA B4DGX8_HUMAN B4DGX8_HUMAN CPQDCLRGSIVGGHEPGEPR-GIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIA RET_MOUSE RET_MOUSE CPQDCLRADIVGGHERGERQ-GIKAGYGICNCFPDEKKCFCEPEDSQGPLCDALCRTIIT Q9EPA1_RAT Q9EPA1_RAT CPQDCLRGPIVGGHERGERQ-GIKAGYGICNCFPDEKKCFCEPEDSQAPLCDELCRTVIT Q9EPC3_RAT Q9EPC3_RAT CPQDCLRGPIVGGHERGERQ-GIKAGYGICNCFPDEKKCFCEPEDSQAPLCDELCRTVIT MATCH ***** : **: . **::*:* * * :*:** : . :*: *:*:*: CONSENSUS CPQDC????I?GG?E??????GIKAG?G?C?C?????KCFCE????????C???C?TVIA

Q9YH35_TETFL Q9YH35_TETFL TALLLSFIVSILLSSYFIHRYHKNSPKPPIASAEMTFRRPAQAYPISFPANNLRRGSQES P79726_DANRE P79726_DANRE TGIILSFIVSVLLSSYFIHRYHKTTPKPPIASAEMTFRRPAQSYPISYSANNVRRASLDS A8E7C7_DANRE A8E7C7_DANRE TGIILSFIVSVLLSSYFIHRYHKTTPKPPIASAEMTFRRPAQSYPISYSANNVRRASLDS O42362_DANRE O42362_DANRE TGIILSFIVSVLLSSYFIHRYHKTTPKPPIASAEMTFRRPAQSYPISYSANNVRRASLDS A8E7C6_DANRE A8E7C6_DANRE TGIILSFIVSVLLSSYFIHRYHKTTPKPPIASAEMTFRRPAQSYPISYSANNVRRASLDS B7ZRI5_XENLA B7ZRI5_XENLA CGVFLSFIISILLSSYFIHRYHKNSPKPPIASAEMTFRRPAQSYPVSYSSNNARRPSLDS B7ZRI3_XENLA B7ZRI3_XENLA CGVFLSFIISVLLSSYFIHRYHKNSPKPPIASAEMTFRRPAQSYPVSYSSNNARRPSLDS Q9DGL0_XENLA Q9DGL0_XENLA CGVFLSFIISVLLSSYFIHRYHKNSPKPPIASAEMTFRRPAQSYPVSYSSNNARRPSLDS Q90601_CHICK Q90601_CHICK GAVLLSFIISVLLSSYFIHRYHKNSPKPPIASAEMTFRRPAQSYPISYSSTNVRRPSLDS Q9PSD4_CHICK Q9PSD4_CHICK GAVLFSFIISVLLSSYFIHRYHKNSPKPPIASAEMTFRRPAQSYPISYSSTNVRRPSLDS Q9UMQ4_HUMAN Q9UMQ4_HUMAN AAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDS RET_HUMAN RET_HUMAN AAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDS Q9BTB0_HUMAN Q9BTB0_HUMAN AAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSSARRPSLDS A8K6Z2_HUMAN A8K6Z2_HUMAN AAVLFSFIVSVLLSAFCIHCYHKFSHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDS B4DGX8_HUMAN B4DGX8_HUMAN AAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDS RET_MOUSE RET_MOUSE AA-LFSLIISILLSIFCVCHHHKHGHKPPIASAEMTFCRPAQGFPISYSSSGTRRPSLDS Q9EPA1_RAT Q9EPA1_RAT AAVLFSFIISVLLSTFCIHRYHKHXXKPPIXSAEMTFCRPAQGFPISYSSSGXRRPSLDS Q9EPC3_RAT Q9EPC3_RAT AAVLFSFIISVLLSTFCIHRYHKHXXKPPIXSAEMTFCRPAQGFPISYSSSGXRRPSLDS MATCH . ::*:*:*:*** : : :** **** ****** ****.:*:*:.:.. ** * :* CONSENSUS ?????SFI?SVLLS???IH?YHK???KPPI?SAEMTFRRPAQ??P?SYS????RR?SLDS

Q9YH35_TETFL Q9YH35_TETFL IET----DTFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGKAGYTTVAVKM P79726_DANRE P79726_DANRE MENQVAIDTFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGKAGYTTVAVKM A8E7C7_DANRE A8E7C7_DANRE MENQVAIDTFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGKAGYTTVAVKM O42362_DANRE O42362_DANRE MENQVAIDTFKIPEDPKWEFPRKNLVLGKTVGEGEFGKVVKATAFRLKGKAGYTTVAVKM A8E7C6_DANRE A8E7C6_DANRE MENQVAIDTFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGKAGYTTVAVKM B7ZRI5_XENLA B7ZRI5_XENLA MENQMSVDTFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGKAGYTTVAVKM B7ZRI3_XENLA B7ZRI3_XENLA MENQMSVDTFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGKAGYTTVAVKM Q9DGL0_XENLA Q9DGL0_XENLA MENQMSVDTFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGKAGYTTVAVKM Q90601_CHICK Q90601_CHICK MENQVSVDTFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKM Q9PSD4_CHICK Q9PSD4_CHICK MENQVSVDTFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKM Q9UMQ4_HUMAN Q9UMQ4_HUMAN MENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKM RET_HUMAN RET_HUMAN MENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKM Q9BTB0_HUMAN Q9BTB0_HUMAN MENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKM A8K6Z2_HUMAN A8K6Z2_HUMAN MENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKM B4DGX8_HUMAN B4DGX8_HUMAN MENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKM RET_MOUSE RET_MOUSE TENQVPVDSFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKM Q9EPA1_RAT Q9EPA1_RAT MENQVSVDSFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKDRAGYTTVAVKM Q9EPC3_RAT Q9EPC3_RAT MENQVSVDSFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKDRAGYTTVAVKM MATCH *. *:*** *****************:**************:**.:********** CONSENSUS MENQ???D?FKI?EDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF?LKG?AGYTTVAVKM

Q9YH35_TETFL Q9YH35_TETFL LKENASHSGLRSLLSEFTLLKQVNHPHVIKMYGACSQDGPLYLIVEYAKYGSLRNFLRES P79726_DANRE P79726_DANRE LKENASHSELRDLLSEFTLLKQVNHPHVIKMYGACSQDGPLYLIVEYAKYGSLRNFLRES A8E7C7_DANRE A8E7C7_DANRE LKENASHSELRDLLSEFTLLKQVNHPHVIKMYGACSQDGPLYLIVEYAKYGSLRNFLRES O42362_DANRE O42362_DANRE LKENASHSELRDLLSEFTLLKQVNHPHVIKMYGACSQDGPLYLIVEYAKYGSLRNFLRES A8E7C6_DANRE A8E7C6_DANRE LKENASHSELRDLLSEFTLLKQVNHPHVIKMYGACSQDGPLYLIVEYAKYGSLRNFLRES B7ZRI5_XENLA B7ZRI5_XENLA LKESASQSELRDLLSEFNLLKQVNHPHVIKLYGACTQDGPLHLIVEYAKYGSLRSFLRES B7ZRI3_XENLA B7ZRI3_XENLA LKESASQSELRDLLSEFNLLKQVNHPHVIKLYGACTQDGPLHLIVEYAKYGSLRSFLRES Q9DGL0_XENLA Q9DGL0_XENLA LKESASQSELRDLLSEFNLLKQVNHPHVIKLYGACTQDGPLHLIVEYSKYGSLRSFLRES Q90601_CHICK Q90601_CHICK LKENASQSELRDLLSEFNLLKQVNHPHVIKLYGACSQDGPLYLIVEYAKYGSLRSFLRES Q9PSD4_CHICK Q9PSD4_CHICK LKENASQSELRDLLSEFNLLKQGNHPHVIKLYGACSQDGPLYLIVEYAKYGSLRSFLRES Q9UMQ4_HUMAN Q9UMQ4_HUMAN LKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRES RET_HUMAN RET_HUMAN LKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRES Q9BTB0_HUMAN Q9BTB0_HUMAN LKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRES A8K6Z2_HUMAN A8K6Z2_HUMAN LKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRES B4DGX8_HUMAN B4DGX8_HUMAN LKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRES RET_MOUSE RET_MOUSE LKENASQSELRDLLSEFNLLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDS Q9EPA1_RAT Q9EPA1_RAT LKENASQSELRDLLSEFNLLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDS Q9EPC3_RAT Q9EPC3_RAT LKENASQSELRDLLSEFNLLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDS MATCH ***.** * **.*****.:*** *******:****:***** *****:******.***:* CONSENSUS LKENAS?SELRDLLSEF??LKQVNHPHVIK?YGACSQDGPL?LIVEYAKYGSLR?FLRES

Q9YH35_TETFL Q9YH35_TETFL RKVGPSYMGRDANRNSSYLENPDDRALTMGDLISFAWQISRGMQYLAEMKLVHRDLAARN P79726_DANRE P79726_DANRE RKVGPSYMGNDANRNSSYLENPDERALTMGDLISFAWQISRGMQYLAEMKLVHRDLAARN A8E7C7_DANRE A8E7C7_DANRE RKVGPSYMGNDANRNSSYLENPDERALTMGDLISFAWQISRGMQYLAEMKLVHRDLAARN O42362_DANRE O42362_DANRE RKVGPSYMGNDANRNSSYLENPDERALTMGDLISFAWQISRGMQYLAEMKLVHRDLAARN A8E7C6_DANRE A8E7C6_DANRE RKVGPSYMGNDANRNSSYLENPDERALTMGDLISFAWQISRGMQYLAEMKLVHRDLAARN B7ZRI5_XENLA B7ZRI5_XENLA RKVGPSSLGGDSNRNSSYLDNPDERALTMGDLISFAWQISRGMQYLAEMKLVHRDLAARN B7ZRI3_XENLA B7ZRI3_XENLA RKVGPSSLGGDSNRNSSYLDNPDERALTMGDLISFAWQISRGMQYLAEMKLVHRDLAARN Q9DGL0_XENLA Q9DGL0_XENLA RKVGPSTLGGDSNRNSSYLDNPDERALTMGDLISFAWQISRGMQYLAEMKLVHRDLAARN Q90601_CHICK Q90601_CHICK RKVGPSYVGSDGNRNSSYLDNPDERALTMGDLISFAWQISRGMQYLAEMKLVHRDLAARN Q9PSD4_CHICK Q9PSD4_CHICK RKVGPSYVGSDGNRNSSYLDNPDERALTMGDLISFAWQISRGMQYLAEMKLVHRDLAARN Q9UMQ4_HUMAN Q9UMQ4_HUMAN RKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARN RET_HUMAN RET_HUMAN RKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARN Q9BTB0_HUMAN Q9BTB0_HUMAN RKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARN A8K6Z2_HUMAN A8K6Z2_HUMAN RKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARN B4DGX8_HUMAN B4DGX8_HUMAN RKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARN RET_MOUSE RET_MOUSE RKIGPAYVSGGGSRNSSSLDHPDERVLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARN Q9EPA1_RAT Q9EPA1_RAT RKIGPAYVSSGGSRNSSSLDHPDERVLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARN Q9EPC3_RAT Q9EPC3_RAT RKIGPAYVSSGGSRNSSSLDHPDERVLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARN MATCH **:**. :. ...**** *::**:*.**************:******************* CONSENSUS RKVGP?Y?G????RNSS?L??PDERALTMGDLISFAWQIS?GMQYLAEMKLVHRDLAARN

Q9YH35_TETFL Q9YH35_TETFL VLVAEGRKMKISDFGLSRDVYEEDSYVKRSK-GRIPVKWMAIESLFDHIYTTQSDVWSFG P79726_DANRE P79726_DANRE VLVAEGRKMKISDFGLSRDVYEEDSYVKRSK-GRIPVKWMATESLFDHIYTTQSDVWSFG A8E7C7_DANRE A8E7C7_DANRE VLVAEGRKMKISDFGLSRDVYEEDSYVKRSK-GRIPVKWMAIESLFDHIYTTQSDVWSFG O42362_DANRE O42362_DANRE VLVAEGRKMKISDFGLSRDVYEEDSYVKRSK-GRIPVKWMAIESLFDHIYTTQSDVWSFG A8E7C6_DANRE A8E7C6_DANRE VLVAEGRKMKISDFGLSRDVYEEDSYVKRSK-GRIPVKWMAIESLFDHIYTTQSDVWSFG B7ZRI5_XENLA B7ZRI5_XENLA VLVAEGRKMKISDFGLSRDVYEEDSYVKRSK-GRIPVKWMAIESLFDHIYTTQSDVWSFG B7ZRI3_XENLA B7ZRI3_XENLA VLVAEGRKMKISDFGLSRDVYEEDSYVKRSK-GRIPVKWMAIESLFDHIYTTQSDVWSFG Q9DGL0_XENLA Q9DGL0_XENLA VLVAEGRKMKISDFGLSRDVYEEDSYVKRSK-GRIPVKWMAIESLFDHIYTTQSDVWSFG Q90601_CHICK Q90601_CHICK VLVAEGRKMKISDFGLSRDVYEEDSYVKRSK-GRIPVKWMAIESLFDHIYTTQSDVWSFG Q9PSD4_CHICK Q9PSD4_CHICK VLVAEGRKMKISDFGLSRDVYEEDSYVKRSK-GRIPVKWMGIESLFDHIYTTQSDVCSFG Q9UMQ4_HUMAN Q9UMQ4_HUMAN ILVAEGRKMKISDFGLSRDVYEEDSYVKRSQVGRIPVKWMAIESLFDHIYTTQSDVWSFG RET_HUMAN RET_HUMAN ILVAEGRKMKISDFGLSRDVYEEDSYVKRSQ-GRIPVKWMAIESLFDHIYTTQSDVWSFG Q9BTB0_HUMAN Q9BTB0_HUMAN ILVAEGRKMKISDFGLSRDVYEEDSYVKRSQ-GRIPVKWMAIESLFDHIYTTQSDVWSFG A8K6Z2_HUMAN A8K6Z2_HUMAN ILVAEGRKMKISDFGLSRDVYEEDSYVKRSQ-GRIPVKWMAIESLFDHIYTTQSDVWSFG B4DGX8_HUMAN B4DGX8_HUMAN ILVAEGRKMKISDFGLSRDVYEEDSYVKRSQ-GRIPVKWMAIESLFDHIYTTQSDVWSFG RET_MOUSE RET_MOUSE ILVAEGRKMKISDFGLSRDVYEEDSYVKKSK-GRIPVKWMAIESLFDHIYTTQSDVWSFG Q9EPA1_RAT Q9EPA1_RAT ILVAEGRKMKISDFGLSRDVYEEDSYVKKSX-GRIPVNWMAINSLSDHFYTTQSDVWSFG Q9EPC3_RAT Q9EPC3_RAT ILVAEGRKMKISDFGLSRDVYEEDSYVKKSX-GRIPVNWMAINSLSDHFYTTQSDVWSFG MATCH :***************************:* *****:**. :** **:******* *** CONSENSUS ?LVAEGRKMKISDFGLSRDVYEEDSYVKRS??GRIPVKWMAIESLFDHIYTTQSDVWSFG

Q9YH35_TETFL Q9YH35_TETFL VLLWEIVMLGGNPYPGIAPERLFNLLKTGYRMERPENCSEEMYNLMLRCWKQEADKRPTF P79726_DANRE P79726_DANRE VLLWEIVTLGGNPYPGIAPERLFNLLKTGYRMEKPENCTDEMYNLMLRCWKQESDKRPTF A8E7C7_DANRE A8E7C7_DANRE VLLWEIVTLGGNPYPGIAPERLFNLLKTGYRMEKPENCTDEMYNLMLRCWKQESDKRPTF O42362_DANRE O42362_DANRE VLLWEIVTLGGNPYPGIAPERLFNLLKTGYRMEKPENCTDEMYNLMLRCWKQESDKRPTF A8E7C6_DANRE A8E7C6_DANRE VLLWEIVTLGGNPYPGIAPERLFNLLKTGYRMEKPENCTDEMYNLMLRCWKQESDKRPTF B7ZRI5_XENLA B7ZRI5_XENLA VLLWEIVTLGGNPYPGIAPERLFNLLKTGYRMEKPENCSDEMYNLMLKCWKQEPEKRQTF B7ZRI3_XENLA B7ZRI3_XENLA VLLWEIVTLGGNPYPGIAPERLFNLLKTGYRMEKPENCSDEMYNLMLKCWKQEPEKRQTF Q9DGL0_XENLA Q9DGL0_XENLA VLLWEIVTLGGNPYPGIAPERLFNLLKTGYRMEKPENCSDEMYNLMLKCWKQEPEKRQTF Q90601_CHICK Q90601_CHICK VLLWEIVTLGGNPYPGIAPERLFNLLKTGYRMERPENCSEEMYNLMLRCWKQEPDKRPTF Q9PSD4_CHICK Q9PSD4_CHICK VLLWEIVTLGANPYPGIAPERLFNLLKTGYRMERPETCSEEMYNLMLRCWKQEPDKRPTF Q9UMQ4_HUMAN Q9UMQ4_HUMAN VLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVF RET_HUMAN RET_HUMAN VLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVF Q9BTB0_HUMAN Q9BTB0_HUMAN VLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYCLMLQCWKQEPDKRPVF A8K6Z2_HUMAN A8K6Z2_HUMAN VLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVF B4DGX8_HUMAN B4DGX8_HUMAN VLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVF RET_MOUSE RET_MOUSE VLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVF Q9EPA1_RAT Q9EPA1_RAT VLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPNNCSEEMYRLMLQCWKQEPDKRPVF Q9EPC3_RAT Q9EPC3_RAT VLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPNNCSEEMYRLMLQCWKQEPDKRPVF MATCH ******* **.******.***********:***:*:.*::*** ***:*****.:** .* CONSENSUS VLLWEIVTLGGNPYPGI?PERLFNLLKTG?RME?P?NC??EMY?LML?CWKQE?DKRP?F

Q9YH35_TETFL Q9YH35_TETFL SDISKELEKMMVKSRDYLDLAASTPADALLYDDALSEEDTPLVDCNNAPLPRTLPSTWIE P79726_DANRE P79726_DANRE SDISKELEKMMVKSRDYLDLAASTPADALLYDDSLSEEDTPLVDCSNAPLPRTLPSTWIE A8E7C7_DANRE A8E7C7_DANRE SDISKELEKMMVKSRDYLDLAASTPADALLYDDSLSEEDTPLVDCSNAPLPRTLPSTWIE O42362_DANRE O42362_DANRE SDISKELEKMMVKSRDYLDLAASTPADALLYDDSLSEEDTPLVDCSNAPLPRTLPSTWIE A8E7C6_DANRE A8E7C6_DANRE SDISKELEKMMVKSRDYLDLAASTPADALLYDDSLSEEDTPLVDCSNAPLPRTLPSTWIE B7ZRI5_XENLA B7ZRI5_XENLA GEISKELEKMMVKSRDYLDLAASTPADSLLYDDGLSEEETPLVDCNNAPLPRTLPSTWIE B7ZRI3_XENLA B7ZRI3_XENLA GEISKELEKMMVKSRDYLDLAASTPADSLLYDDGLSEEETPLVDCNNAPLPRTLPSTWIE Q9DGL0_XENLA Q9DGL0_XENLA GEISKELEKMMVKSRDYLDLAASTPADSLLYDDGLSEEETPLVDCNNAPLPRTLPSTWIE Q90601_CHICK Q90601_CHICK AEISKELEKMMVKSRDYLDLAASTPSDSLLYDDGLSEEETPLVDCNNAPLPRTLPSTWIE Q9PSD4_CHICK Q9PSD4_CHICK AEISKELEKMMVKSRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIE Q9UMQ4_HUMAN Q9UMQ4_HUMAN ADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIE RET_HUMAN RET_HUMAN ADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIE Q9BTB0_HUMAN Q9BTB0_HUMAN ADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIE A8K6Z2_HUMAN A8K6Z2_HUMAN ADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIE B4DGX8_HUMAN B4DGX8_HUMAN ADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIE RET_MOUSE RET_MOUSE ADISKDLEKMMVKSRDYLDLAASTPSDSLLYDDGLSEEETPLVDCNNAPLPRSLPSTWIE Q9EPA1_RAT Q9EPA1_RAT ADISKDLEKMMVKSRDYLDLAASTPSDSLLYDDGLSEEETPLVDCNSAPLPRSLPSTWIE Q9EPC3_RAT Q9EPC3_RAT ADISKDLEKMMVKSRDYLDLAASTPSDSLLYDDGLSEEETPLVDCNSAPLPRSLPSTWIE MATCH .:***:******* ***********:*:*:***.****:******..*****:******* CONSENSUS ??ISK?LEKMMVK?RDYLDLAASTP?D?L?YDD?LSEE?TPLVDC?NAPLPR?LPSTWIE

Q9YH35_TETFL Q9YH35_TETFL NKLYGMSYPNWPEKSPVPLSRHDATNPVFTRYANDSVYANWMALPSPAKAVDKVDS-- P79726_DANRE P79726_DANRE NKLYGMSYPNWPEKSPVPLNRLDATNPVFTRYANDSVYANWMALHSPAKIVDTIDS-- A8E7C7_DANRE A8E7C7_DANRE NKLYGR------------------ISHAFTRF-------------------------- O42362_DANRE O42362_DANRE NKLYGMSYPNWPEKSPVPFNRLDATNPVFTRYANDSVYANWMALHSPAKIVDTIDS-- A8E7C6_DANRE A8E7C6_DANRE NKLYGMSYPNWPEKSPVPLNRLDATNPVFTRYANDSVYANWMALHSPAKIVDTIDS-- B7ZRI5_XENLA B7ZRI5_XENLA NKLYGR------------------ISHAFTRF-------------------------- B7ZRI3_XENLA B7ZRI3_XENLA NKLYGR------------------ISHAFTRF-------------------------- Q9DGL0_XENLA Q9DGL0_XENLA NKLYGR------------------ISHAFTRF-------------------------- Q90601_CHICK Q90601_CHICK NKLYGR------------------ISHAFTRF-------------------------- Q9PSD4_CHICK Q9PSD4_CHICK NKLYGMSYPNWPEESPVPLTRFDGTNSVFSRYANDSVYANWMGFTLNRQNLVDKVWIA Q9UMQ4_HUMAN Q9UMQ4_HUMAN NKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS-- RET_HUMAN RET_HUMAN NKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS-- Q9BTB0_HUMAN Q9BTB0_HUMAN NKLYGR------------------ISHAFTRF-------------------------- A8K6Z2_HUMAN A8K6Z2_HUMAN NKLYGR------------------ISHAFTRF-------------------------- B4DGX8_HUMAN B4DGX8_HUMAN NKLYGR------------------ISHAFTRF-------------------------- RET_MOUSE RET_MOUSE NKLYGMSDPNWPGESPVPLTRADGTSTGFPRYANDSVYANWMVSPSAAKLMDTFDS-- Q9EPA1_RAT Q9EPA1_RAT NKLYGMSDPNWPGESPVPLTRADGTSTGFPRYANDSVYANWMVSPSAAKLMDTFDS-- Q9EPC3_RAT Q9EPC3_RAT NKLYGR------------------ISHAFTRF-------------------------- MATCH ***** . *.*: CONSENSUS NKLYG???????????????????????F?R???????????????????????????


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