Alignment of the gene Family HBG003619 of HOVERGEN

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Isoforms are ON
Q1WF16_FELCA Q1WF16_FELCA ------------------------------------------------------------ Q7T2C1_DANRE Q7T2C1_DANRE ------------------------------------------------------------ Q4SHX5_TETNG Q4SHX5_TETNG ------------------------------------------------------------ B1H1S6_XENLA B1H1S6_XENLA ------------------------------------------------------------ Q08D74_XENTR Q08D74_XENTR ------------------------------------------------------------ Q28FG3_XENTR Q28FG3_XENTR ------------------------------------------------------------ B5X1T6_SALSA B5X1T6_SALSA ------------------------------------------------------------ Q8CHD6_MOUSE Q8CHD6_MOUSE ------------------------------------------------------------ Q9CZM5_MOUSE Q9CZM5_MOUSE ------------------------------------------------------AQVRRT Q99KS9_MOUSE Q99KS9_MOUSE ------------------------------------------------------------ Q8BSL3_MOUSE Q8BSL3_MOUSE SRSTRSKERRENDTDSEDNSSETSNQERRRCRQGPPRPPYPPLLPPVFPPPTPPPQVRRT A2A432_MOUSE A2A432_MOUSE SRSTRSKERRENDTDSEDNSSETSNQERRRCRQGPPRPPYPPLLPPVFPPPTPPPQVRRT Q3TU30_MOUSE Q3TU30_MOUSE ----------------------------------------------------PPPQVRRT B3KVX4_HUMAN B3KVX4_HUMAN ------------------------------------------------------------ B7Z5K8_HUMAN B7Z5K8_HUMAN ------------------------------------------------------------ CUL4B_HUMAN CUL4B_HUMAN ------------------------------------------------------------ Q1WF15_FELCA Q1WF15_FELCA ------------------------------------------------------------ B1APK5_HUMAN B1APK5_HUMAN -------------------------------------------------------MMSQS Q498E8_XENLA Q498E8_XENLA ------------------------------------------------------------ B2GU90_XENTR B2GU90_XENTR ------------------------------------------------------------ B3DLE7_XENTR B3DLE7_XENTR ------------------------------------------------------------ B3DLF2_XENTR B3DLF2_XENTR ------------------------------------------------------------ Q4RTC1_TETNG Q4RTC1_TETNG ------------------------------------------------------------ Q4TI50_TETNG Q4TI50_TETNG ------------------------------------------------------------ B3EX44_SORAR B3EX44_SORAR ------------------------------------------------------------ B2RYJ3_RAT B2RYJ3_RAT ------------------------------------------------------------ Q8R1T2_MOUSE Q8R1T2_MOUSE ------------------------------------------------------------ CUL4A_MOUSE CUL4A_MOUSE ------------------------------------------------------------ Q3UD60_MOUSE Q3UD60_MOUSE ------------------------------------------------------------ B4USY1_OTOGA B4USY1_OTOGA ------------------------------------------------------------ B2RBV7_HUMAN B2RBV7_HUMAN ------------------------------------------------------------ CUL4A_HUMAN CUL4A_HUMAN ------------------------------------------------------------ A8MSH7_HUMAN A8MSH7_HUMAN ------------------------------------------------------------ B4DKT2_HUMAN B4DKT2_HUMAN ------------------------------------------------------------ Q4RV94_TETNG Q4RV94_TETNG ------------------------------------------------------------ Q6P0Z1_DANRE Q6P0Z1_DANRE ------------------------------------------------------------ Q6TEL5_DANRE Q6TEL5_DANRE ------------------------------------------------------------ B3DIU1_DANRE B3DIU1_DANRE ------------------------------------------------------------ CUL3_MOUSE CUL3_MOUSE ------------------------------------------------------------ Q6ZQ84_MOUSE Q6ZQ84_MOUSE ------------------------------------------------------------ B5DF89_RAT B5DF89_RAT ------------------------------------------------------------ CUL3_HUMAN CUL3_HUMAN ------------------------------------------------------------ Q53S54_HUMAN Q53S54_HUMAN ------------------------------------------------------------ B8ZZC3_HUMAN B8ZZC3_HUMAN ------------------------------------------------------------ Q4R4A5_MACFA Q4R4A5_MACFA ------------------------------------------------------------ B7Z600_HUMAN B7Z600_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q1WF16_FELCA Q1WF16_FELCA ------------------------------------------------------------ Q7T2C1_DANRE Q7T2C1_DANRE ------------------------------------------------------------ Q4SHX5_TETNG Q4SHX5_TETNG ------------------------------------------------------------ B1H1S6_XENLA B1H1S6_XENLA ------------------------------------------------------------ Q08D74_XENTR Q08D74_XENTR ------------------------------------------------------------ Q28FG3_XENTR Q28FG3_XENTR ------------------------------------------------------------ B5X1T6_SALSA B5X1T6_SALSA ---------------MFPTGLPSPNPPPPTQEARPAASDVNNDSSSITNSKKRKINRSER Q8CHD6_MOUSE Q8CHD6_MOUSE ------------------------------------------------------------ Q9CZM5_MOUSE Q9CZM5_MOUSE RGLQDLGAMKSVCPGTSGFSSPNPSAASAAAQEVRSATDGNTSTTPPTSAKKRKLN-SSS Q99KS9_MOUSE Q99KS9_MOUSE ------------------------------------------------------------ Q8BSL3_MOUSE Q8BSL3_MOUSE RGLQDLGAMKSVCPGTSGFSSPNPSAASAAAQEVRSATDGNTSTTPPTSAKKRKLN-SSS A2A432_MOUSE A2A432_MOUSE RGLQDLGAMKSVCPGTSGFSSPNPSAASAAAQEVRSATDGNTSTTPPTSAKKRKLN-SSS Q3TU30_MOUSE Q3TU30_MOUSE RGLQDLGAMKSVCPGTSGFSSPNPSAASAAAQEVRSATDGNTSTTPPTSAKKRKLN-SSS B3KVX4_HUMAN B3KVX4_HUMAN -------------MFPTGFSSPSPSAA-AAAQEVRSATDGNTSTTPPTSAKKRKLNSSSS B7Z5K8_HUMAN B7Z5K8_HUMAN ------------------------------------------------------------ CUL4B_HUMAN CUL4B_HUMAN -------------MFPTGFSSPSPSAA-AAAQEVRSATDGNTSTTPPTSAKKRKLNSSSS Q1WF15_FELCA Q1WF15_FELCA ------------------------------------------------------------ B1APK5_HUMAN B1APK5_HUMAN SGSGDGNDDEATTSKDGGFSSPSPSAA-AAAQEVRSATDGNTSTTPPTSAKKRKLNSSSS Q498E8_XENLA Q498E8_XENLA ----------------------------------------------MKDLVASPSGQSKQ B2GU90_XENTR B2GU90_XENTR --------------------------------------------------------MFPT B3DLE7_XENTR B3DLE7_XENTR ------------------------------------------------------------ B3DLF2_XENTR B3DLF2_XENTR ------------------------------------------------------------ Q4RTC1_TETNG Q4RTC1_TETNG ------------------------------------------------------------ Q4TI50_TETNG Q4TI50_TETNG ------------------------------------------------------------ B3EX44_SORAR B3EX44_SORAR ------------------------------------------------------------ B2RYJ3_RAT B2RYJ3_RAT ------------------------------------------------------------ Q8R1T2_MOUSE Q8R1T2_MOUSE ------------------------------------------------------------ CUL4A_MOUSE CUL4A_MOUSE ------------------------------------------------------------ Q3UD60_MOUSE Q3UD60_MOUSE ------------------------------------------------------------ B4USY1_OTOGA B4USY1_OTOGA ------------------------------------------------------------ B2RBV7_HUMAN B2RBV7_HUMAN ------------------------------------------------------------ CUL4A_HUMAN CUL4A_HUMAN ------------------------------------------------------------ A8MSH7_HUMAN A8MSH7_HUMAN ------------------------------------------------------------ B4DKT2_HUMAN B4DKT2_HUMAN ------------------------------------------------------------ Q4RV94_TETNG Q4RV94_TETNG ------------------------------------------------------------ Q6P0Z1_DANRE Q6P0Z1_DANRE ------------------------------------------------------------ Q6TEL5_DANRE Q6TEL5_DANRE ------------------------------------------------------------ B3DIU1_DANRE B3DIU1_DANRE ------------------------------------------------------------ CUL3_MOUSE CUL3_MOUSE ------------------------------------------------------------ Q6ZQ84_MOUSE Q6ZQ84_MOUSE ------------------------------------------------------------ B5DF89_RAT B5DF89_RAT ------------------------------------------------------------ CUL3_HUMAN CUL3_HUMAN ------------------------------------------------------------ Q53S54_HUMAN Q53S54_HUMAN ------------------------------------------------------------ B8ZZC3_HUMAN B8ZZC3_HUMAN ------------------------------------------------------------ Q4R4A5_MACFA Q4R4A5_MACFA ------------------------------------------------------------ B7Z600_HUMAN B7Z600_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q1WF16_FELCA Q1WF16_FELCA ------------------------------------------------------------ Q7T2C1_DANRE Q7T2C1_DANRE ------------------------------------------------------------ Q4SHX5_TETNG Q4SHX5_TETNG ------------------------------------------------------------ B1H1S6_XENLA B1H1S6_XENLA ------------------------------------------------------------ Q08D74_XENTR Q08D74_XENTR ------------------------------------------------------------ Q28FG3_XENTR Q28FG3_XENTR ------------------------------------------------------------ B5X1T6_SALSA B5X1T6_SALSA EDIDSISASPKTNNSSSSSTSQ---------------------------QIQKKLRFEDS Q8CHD6_MOUSE Q8CHD6_MOUSE ------------------------------------------------------------ Q9CZM5_MOUSE Q9CZM5_MOUSE SSSNSSNEREDFDSTSSSSTPP--QPRDSASPSTSSFCLGVPVATSSHVPIQKKLRFEDT Q99KS9_MOUSE Q99KS9_MOUSE ------------------------------------------------------------ Q8BSL3_MOUSE Q8BSL3_MOUSE SSSNSSNEREDFDSTSSSSTPP--QPRDSASPSTSSFCLGVPVATSSHVPIQKKLRFEDT A2A432_MOUSE A2A432_MOUSE SSSNSSNEREDFDSTSSSSTPP--QPRDSASPSTSSFCLGVPVATSSHVPIQKKLRFEDT Q3TU30_MOUSE Q3TU30_MOUSE SSSNSSNEREDFDSTSSSSTPP--QPRDSASPSTSSFCLGVPVATSSHVPIQKKLRFEDT B3KVX4_HUMAN B3KVX4_HUMAN SSSNRSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLRFEDT B7Z5K8_HUMAN B7Z5K8_HUMAN ------------------------------------------------------------ CUL4B_HUMAN CUL4B_HUMAN SSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLRFEDT Q1WF15_FELCA Q1WF15_FELCA ------------------------------------------------------------ B1APK5_HUMAN B1APK5_HUMAN SSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLRFEDT Q498E8_XENLA Q498E8_XENLA GLSSPNPPAQEVRTEGNSTSKKRRLNISSSDKDDLDPLSPARNSSSSSNHIQKKLRFEDT B2GU90_XENTR B2GU90_XENTR GLSTPNPPAQEVRTEGNSTSKKRRLNISSSDKDDLDPLSPPRNSSSSSNHIQKKLRFEDT B3DLE7_XENTR B3DLE7_XENTR ------------------------------------------------------------ B3DLF2_XENTR B3DLF2_XENTR ------------------------------------------------------------ Q4RTC1_TETNG Q4RTC1_TETNG ------------------------------------------------------------ Q4TI50_TETNG Q4TI50_TETNG ------------------------------------------------------------ B3EX44_SORAR B3EX44_SORAR ------------------------------------------------------------ B2RYJ3_RAT B2RYJ3_RAT ------------------------------------------------------------ Q8R1T2_MOUSE Q8R1T2_MOUSE ------------------------------------------------------------ CUL4A_MOUSE CUL4A_MOUSE ------------------------------------------------------------ Q3UD60_MOUSE Q3UD60_MOUSE ------------------------------------------------------------ B4USY1_OTOGA B4USY1_OTOGA ------------------------------------------------------------ B2RBV7_HUMAN B2RBV7_HUMAN ------------------------------------------------------------ CUL4A_HUMAN CUL4A_HUMAN ------------------------------------------------------------ A8MSH7_HUMAN A8MSH7_HUMAN ------------------------------------------------------------ B4DKT2_HUMAN B4DKT2_HUMAN ------------------------------------------------------------ Q4RV94_TETNG Q4RV94_TETNG ------------------------------------------------------------ Q6P0Z1_DANRE Q6P0Z1_DANRE ------------------------------------------------------------ Q6TEL5_DANRE Q6TEL5_DANRE ------------------------------------------------------------ B3DIU1_DANRE B3DIU1_DANRE ------------------------------------------------------------ CUL3_MOUSE CUL3_MOUSE ------------------------------------------------------------ Q6ZQ84_MOUSE Q6ZQ84_MOUSE ------------------------------------------------------------ B5DF89_RAT B5DF89_RAT ------------------------------------------------------------ CUL3_HUMAN CUL3_HUMAN ------------------------------------------------------------ Q53S54_HUMAN Q53S54_HUMAN ------------------------------------------------------------ B8ZZC3_HUMAN B8ZZC3_HUMAN ------------------------------------------------------------ Q4R4A5_MACFA Q4R4A5_MACFA ------------------------------------------------------------ B7Z600_HUMAN B7Z600_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q1WF16_FELCA Q1WF16_FELCA ---------------MPQQDSSPSSAAAASQKQERLKNVKLIVFSVAADHHNNDLTKAPT Q7T2C1_DANRE Q7T2C1_DANRE -------------------------------------------------MAEDVQHQQKS Q4SHX5_TETNG Q4SHX5_TETNG ------------------------------------------------------------ B1H1S6_XENLA B1H1S6_XENLA ------------------------------------------------------------ Q08D74_XENTR Q08D74_XENTR ---------MAQEAQKKANFS-------------------------TLAGHTNGLTKSSA Q28FG3_XENTR Q28FG3_XENTR ---------MAQEAQKKANFS-------------------------TLAGHTNGLTKSSA B5X1T6_SALSA B5X1T6_SALSA VDFIGLGVKMAEESASCSSNKTKT-----------------VFLAGVVGHHANGLTKTAG Q8CHD6_MOUSE Q8CHD6_MOUSE --------------------------TSQQEQQQQLKTKSILISSVASVHHANGLAKSST Q9CZM5_MOUSE Q9CZM5_MOUSE LEFVGIDTKMAEESSSSSSSSSPTAATSQQQQQQQLKTKSILISSVASVHHANGLAKSST Q99KS9_MOUSE Q99KS9_MOUSE ------------------------------------------------------------ Q8BSL3_MOUSE Q8BSL3_MOUSE LEFVGIDTKMAEESSSSSSSSSPTAATSQQQQQQQLKTKSILISSVASVHHANGLAKSST A2A432_MOUSE A2A432_MOUSE LEFVGIDTKMAEESSSSSSSSSPTAATSQQQQQQQLKTKSILISSVASVHHANGLAKSST Q3TU30_MOUSE Q3TU30_MOUSE LEFVGIDTKMAEESSSSSSSSSPTAATSQQQQQQQLKTKSILISSVASVHHANGLAKSST B3KVX4_HUMAN B3KVX4_HUMAN LEFVGFDAKMAEESSSSPSSSSPTAATS---QQQQLKNKSILISSVASVHHANGLAKSST B7Z5K8_HUMAN B7Z5K8_HUMAN ------------------------------------------------------------ CUL4B_HUMAN CUL4B_HUMAN LEFVGFDAKMAEESSSSSSSSSPTAATS---QQQQLKNKSILISSVASVHHANGLAKSST Q1WF15_FELCA Q1WF15_FELCA ---------MAEESSSSSSSSSPTAATS---QQQQLKNKSILISSVASVHHANGLAKSST B1APK5_HUMAN B1APK5_HUMAN LEFVGFDAKMAEESSSSSSSSSPTAATS---QQQQLKNKSILISSVASVHHANGLAKSST Q498E8_XENLA Q498E8_XENLA LDFLGLDVKMTEESSSSSSCSFSS-------TPQAVRSKNLLISPVGVGHHANGLTKAS- B2GU90_XENTR B2GU90_XENTR LDFLGLDVKMAEESPSSSCSSSST--------PQAVRSKNLLISPVGVGHHANGLTKAS- B3DLE7_XENTR B3DLE7_XENTR ------------------------------------------------------------ B3DLF2_XENTR B3DLF2_XENTR ------------------------------------------------------------ Q4RTC1_TETNG Q4RTC1_TETNG ----------MKNTRIQQRCRRQL-------DRVWPLVSKAVFLSSGVGHHANGLAKTA- Q4TI50_TETNG Q4TI50_TETNG ------------------------------------------------------------ B3EX44_SORAR B3EX44_SORAR ---------MAEEAPRKGGFS-------------------------ALVGHTNGLSRPAA B2RYJ3_RAT B2RYJ3_RAT ---------MADEGPRKGSVS-------------------------ALMGRTNGLTKPAA Q8R1T2_MOUSE Q8R1T2_MOUSE ------------------------------------------------------------ CUL4A_MOUSE CUL4A_MOUSE ---------MADEGPRKGSVS-------------------------ALMGRTNGLTKPAA Q3UD60_MOUSE Q3UD60_MOUSE ---------MADEGPRKGSVS-------------------------ALMGRTNGLTKPAA B4USY1_OTOGA B4USY1_OTOGA ---------MADEAPRKGSFS-------------------------ALVGRTNGLTKPAA B2RBV7_HUMAN B2RBV7_HUMAN ------------------------------------------------------------ CUL4A_HUMAN CUL4A_HUMAN ---------MADEAPRKGSFS-------------------------ALVGRTNGLTKPAA A8MSH7_HUMAN A8MSH7_HUMAN ---------MADEAPRKGSFS-------------------------ALVGRTNGLTKPAA B4DKT2_HUMAN B4DKT2_HUMAN ------------------------------------------------------------ Q4RV94_TETNG Q4RV94_TETNG ------------------------------------------------------------ Q6P0Z1_DANRE Q6P0Z1_DANRE ------------------------------------------------------------ Q6TEL5_DANRE Q6TEL5_DANRE ------------------------------------------------------------ B3DIU1_DANRE B3DIU1_DANRE ------------------------------------------------------------ CUL3_MOUSE CUL3_MOUSE ------------------------------------------------------------ Q6ZQ84_MOUSE Q6ZQ84_MOUSE ----------------------------------------HRRLRVRAAAAAAVSAAAGE B5DF89_RAT B5DF89_RAT ------------------------------------------------------------ CUL3_HUMAN CUL3_HUMAN ------------------------------------------------------------ Q53S54_HUMAN Q53S54_HUMAN ------------------------------------------------------------ B8ZZC3_HUMAN B8ZZC3_HUMAN ------------------------------------------------------------ Q4R4A5_MACFA Q4R4A5_MACFA ------------------------------------------------------------ B7Z600_HUMAN B7Z600_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q1WF16_FELCA Q1WF16_FELCA TLSSFASNMLGTGSVKKLVIKNFKDKPLPLENYTEETWQKLKEAVQAVQNSISVKYSLEE Q7T2C1_DANRE Q7T2C1_DANRE SFNGLSKSA-KAGASKKLVIKNFKDRPKLTDSYTEDTWLKLRDAVSAIQNSTSIQYNLEE Q4SHX5_TETNG Q4SHX5_TETNG ------------------------DRPKLSENYTEDTWLKLRDAVGAIQNSTSIKYNLEE B1H1S6_XENLA B1H1S6_XENLA ------------------------------------------EAVNAIESSTSIKYNLEE Q08D74_XENTR Q08D74_XENTR LTS-------KPSASKKLIIKNFKDKPKLPDSYTQDTWQKLQEAVNAIESSTSIKYNLEE Q28FG3_XENTR Q28FG3_XENTR LTS-------KPSASKKLIIKNFKDKPKLPDSYTQDTWQKLQEAVNAIESSTSIKYNLEE B5X1T6_SALSA B5X1T6_SALSA STTFSNS---KPGAAKKLVIKNFKEKPKLPENYTHETWQKLKEAVEAIQNSTSIKYNLEE Q8CHD6_MOUSE Q8CHD6_MOUSE AVSSFANS--KPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEE Q9CZM5_MOUSE Q9CZM5_MOUSE AVSSFANS--KPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEE Q99KS9_MOUSE Q99KS9_MOUSE ------------------------------------------------------------ Q8BSL3_MOUSE Q8BSL3_MOUSE AVSSFANS--KPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEE A2A432_MOUSE A2A432_MOUSE AVSSFANS--KPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEE Q3TU30_MOUSE Q3TU30_MOUSE AVSSFANS--KPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEE B3KVX4_HUMAN B3KVX4_HUMAN TVSSFANS--KPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEE B7Z5K8_HUMAN B7Z5K8_HUMAN -----------------MIDPDFADKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEE CUL4B_HUMAN CUL4B_HUMAN TVSSFANS--KPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEE Q1WF15_FELCA Q1WF15_FELCA TTSSFANS--KPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEE B1APK5_HUMAN B1APK5_HUMAN TVSSFANS--KPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEE Q498E8_XENLA Q498E8_XENLA PVSSFANS--KPGSAKKLVIKNFKDKPKLPENYTDETWQKLKGTVEAIQNSTSIKYNLEE B2GU90_XENTR B2GU90_XENTR PVSSFANS--KPGSAKKLVIKNFKDKPKLPENYTDETWQKLKGAVEAIQNSTSIKYNLEE B3DLE7_XENTR B3DLE7_XENTR ------------------------------------------------------------ B3DLF2_XENTR B3DLF2_XENTR ------------------------------------------------------------ Q4RTC1_TETNG Q4RTC1_TETNG GSATFSNS--KPGAAKKLVIKNFKEKPKLPENYTQETWQKLKEAVEAIQNSTSIKYNLEE Q4TI50_TETNG Q4TI50_TETNG ------------------------------------------------------------ B3EX44_SORAR B3EX44_SORAR LAAAAVSS--APGGSKKLVIKNFRDRPRLPDNYTQDTWRQLHEAVRAIQSSTPVTCNLEE B2RYJ3_RAT B2RYJ3_RAT LASGPAKPG-GTGGSRKLVIKNFRDRPRLPDNYTQDTWRKLHEAVKAIQSSTSIRYNLEE Q8R1T2_MOUSE Q8R1T2_MOUSE ------------------------------------------------------------ CUL4A_MOUSE CUL4A_MOUSE LAGGPAKPG-GTGGSRKLVIKNFRDRPRLPDNYTQDTWRKLHEAVKAIQSSTSIRYNLEE Q3UD60_MOUSE Q3UD60_MOUSE LAGGPAKPG-GTGGSRKLVIKNFRDRPRLPDNYTQDTWRKLHEAVKAIQSSTSIRYNLEE B4USY1_OTOGA B4USY1_OTOGA LASGPAKPG-GAGGSKKLVIKNFRDRPRLPDNYTQDTWQKLREAVRAVQSSTSVRCNLEE B2RBV7_HUMAN B2RBV7_HUMAN ------------------------------------------------------------ CUL4A_HUMAN CUL4A_HUMAN LAAAPAKPG-GAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEE A8MSH7_HUMAN A8MSH7_HUMAN LAAAPAKPG-GAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEE B4DKT2_HUMAN B4DKT2_HUMAN ------------------------------------------------------------ Q4RV94_TETNG Q4RV94_TETNG --------------------------MDIDDESVDRLWIILKAAIQQILRKDTGGLCFSE Q6P0Z1_DANRE Q6P0Z1_DANRE ------MSNLKPGTKKDTKMRIRAFPMTMDEKYVNNIWDLLKNAIQEIQRKNNSGLSFEE Q6TEL5_DANRE Q6TEL5_DANRE ------MSNLKPGTKKDTKMRIRAFPMTMDEKYVNNIWDLLKNAIQEIQRKNNSGLSFEE B3DIU1_DANRE B3DIU1_DANRE ----MSNLSKG-GTKKDTKMRIRAFPMTMDEKYVNNIWDLLKNAIQEIQRKNNSGLSFEE CUL3_MOUSE CUL3_MOUSE ----MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEE Q6ZQ84_MOUSE Q6ZQ84_MOUSE GPSTMSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEE B5DF89_RAT B5DF89_RAT --------------------------MTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEE CUL3_HUMAN CUL3_HUMAN ----MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEE Q53S54_HUMAN Q53S54_HUMAN --------------------------MTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEE B8ZZC3_HUMAN B8ZZC3_HUMAN ----------------------------MDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEE Q4R4A5_MACFA Q4R4A5_MACFA ------------------------------------------------------------ B7Z600_HUMAN B7Z600_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ???????????????????????????????????????????????????????????E

Q1WF16_FELCA Q1WF16_FELCA LYQSVENLCSYNLSANLYKQLKQLCEQHLKAQIHQF-----------REDSVDNG--PF- Q7T2C1_DANRE Q7T2C1_DANRE LYQAVENLCSYKVSPMLYKQLRQVCEEHVQAQIHQF-----------REESLDSL--SF- Q4SHX5_TETNG Q4SHX5_TETNG LYQAVENLCSYKVSPTLYKQLRQVCEDHVQAQIHHFFFFCIIPLNLDLTEDLDNL--SF- B1H1S6_XENLA B1H1S6_XENLA LYQAVENLCSYKVSHNLYKQLRQVCEEHMKAQIDQF-----------REESLDSF--LF- Q08D74_XENTR Q08D74_XENTR LYQAVENLCSYKVSHTLYKQLRQVCEEHMKAQIHQF-----------REDSLDSF--LF- Q28FG3_XENTR Q28FG3_XENTR LYQAVENLCSYKVSHTLYKQLRQVCEEHMKAQIHQF-----------REDSLDSF--LF- B5X1T6_SALSA B5X1T6_SALSA LYQAVENLCSHKISARLYKQLRVVCEDHIKAQIDQF-----------REDVLDST--LF- Q8CHD6_MOUSE Q8CHD6_MOUSE LYQAVENLCSHKISANLYKQLRQICEDHIKAQIHQF-----------REDSLDSV--LF- Q9CZM5_MOUSE Q9CZM5_MOUSE LYQAVENLCSHKISANLYKQLRQICEDHIKAQIHQF-----------REDSLDSV--LF- Q99KS9_MOUSE Q99KS9_MOUSE ------------------------------------------------------------ Q8BSL3_MOUSE Q8BSL3_MOUSE LYQAVENLCSHKISANLYKQLRQICEDHIKAQIHQF-----------REDSLDSV--LF- A2A432_MOUSE A2A432_MOUSE LYQAVENLCSHKISANLYKQLRQICEDHIKAQIHQF-----------REDSLDSV--LF- Q3TU30_MOUSE Q3TU30_MOUSE LYQAVENLCSHKISANLYKQLRQICEDHIKAQIHQF-----------REDSLDSV--LF- B3KVX4_HUMAN B3KVX4_HUMAN LYQAVENLCSYKISANLYKQLRQICGDHIKAQIHQF-----------REDSLDSV--LF- B7Z5K8_HUMAN B7Z5K8_HUMAN LYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQF-----------REDSLDSV--LF- CUL4B_HUMAN CUL4B_HUMAN LYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQF-----------REDSLDSV--LF- Q1WF15_FELCA Q1WF15_FELCA LYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQF-----------REDSLDSV--LF- B1APK5_HUMAN B1APK5_HUMAN LYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQF-----------REDSLDSV--LF- Q498E8_XENLA Q498E8_XENLA LYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQF-----------REDSLDSV--LF- B2GU90_XENTR B2GU90_XENTR LYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQF-----------REDALDSV--LF- B3DLE7_XENTR B3DLE7_XENTR ------------------------------------------------------------ B3DLF2_XENTR B3DLF2_XENTR ------------------------------------------------------------ Q4RTC1_TETNG Q4RTC1_TETNG LYQAVENLCSHKISAKLYKQLRAVCEDHIKAQIDQF-----------REYPSQFL--ASG Q4TI50_TETNG Q4TI50_TETNG ------------------------------------------------------------ B3EX44_SORAR B3EX44_SORAR LYQAVENLCSHKVSPALYKQLRQ------------------------------------- B2RYJ3_RAT B2RYJ3_RAT LYQAVENLCSHKVSPTLYKQLRQVCEDHVQAQILPF-----------REDSLDSV--LF- Q8R1T2_MOUSE Q8R1T2_MOUSE ------------------------------------------------------------ CUL4A_MOUSE CUL4A_MOUSE LYQAVENLCSHKVSPTLYKQLRQVCEDHVQAQILPF-----------REDSLDSV--LF- Q3UD60_MOUSE Q3UD60_MOUSE LYQAVENLCSHKVSPTLYKQLRQVCEDHVQAQILPF-----------REDSLDSV--LF- B4USY1_OTOGA B4USY1_OTOGA LYQAVENLCSHKVSPTLYKQLRQVCEDHVQAQI--------------------------- B2RBV7_HUMAN B2RBV7_HUMAN ---------------MLYKQLRQACEDHVQAQILPF-----------REDSLDSV--LF- CUL4A_HUMAN CUL4A_HUMAN LYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPF-----------REDSLDSV--LF- A8MSH7_HUMAN A8MSH7_HUMAN LYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPF-----------REYSLDSV--LF- B4DKT2_HUMAN B4DKT2_HUMAN ------------------------------------------------------------ Q4RV94_TETNG Q4RV94_TETNG LYNIAYMLTQQRRAMKMYAGLKEIITQHLSSNV--------------KPEMVDSQKNNF- Q6P0Z1_DANRE Q6P0Z1_DANRE LYRNAYTMVLHKHGEKLYTGLREVVTEHLINKV--------------REDVLHSLNNNF- Q6TEL5_DANRE Q6TEL5_DANRE LYRNAYTMVLHKHGEKLYTGLREVVTEHLINKV--------------REDVLHSLNNNF- B3DIU1_DANRE B3DIU1_DANRE LYRNAYTMVLHKHGEKLYTGLREVVTEHLINKV--------------REDVLNSLNNNF- CUL3_MOUSE CUL3_MOUSE LYRNAYTMVLHKHGEKLYTGLREVVTEHLINKV--------------REDVLNSLNNNF- Q6ZQ84_MOUSE Q6ZQ84_MOUSE LYRNAYTMVLHKHGEKLYTGLREVVTEHLINKV--------------REDVLNSLNNNF- B5DF89_RAT B5DF89_RAT LYRNAYTMVLHKHGEKLYTGLREVVTEHLINKV--------------REDVLNSLNNNF- CUL3_HUMAN CUL3_HUMAN LYRNAYTMVLHKHGEKLYTGLREVVTEHLINKV--------------REDVLNSLNNNF- Q53S54_HUMAN Q53S54_HUMAN LYRNAYTMVLHKHGEKLYTGLREVVTEHLINKV--------------REDVLNSLNNNF- B8ZZC3_HUMAN B8ZZC3_HUMAN LYRNAYTMVLHKHGEKLYTGLREVVTEHLINKV--------------REDVLNSLNNNF- Q4R4A5_MACFA Q4R4A5_MACFA -------MVLHKHGEKLYTGLREVVTEHLINKV--------------REDVLNSLNNNF- B7Z600_HUMAN B7Z600_HUMAN ------------------------------------------------------------ MATCH CONSENSUS LY??????????????LY??LR?????H????????????????????????????????

Q1WF16_FELCA Q1WF16_FELCA ----------------------------LKKVDKCWQNHSRQMSMIRNIFLFLDRTYAFQ Q7T2C1_DANRE Q7T2C1_DANRE ----------------------------LKRMNRCWQDHCRQTIMIRSIFLFLDRTYVLQ Q4SHX5_TETNG Q4SHX5_TETNG ----------------------------LKRMNRCWQDHCRQTIMIRSIFLFLDRTYVLQ B1H1S6_XENLA B1H1S6_XENLA ----------------------------LKKVNRCWKDHCRQMIMIRSIFLFLDRTYVLQ Q08D74_XENTR Q08D74_XENTR ----------------------------LKKVNRCWKDHCRQMIMIRSIFLFLDRTYVLQ Q28FG3_XENTR Q28FG3_XENTR ----------------------------LKKVNRCWKDHCRQMIMIRSIFLFLDRTYVLQ B5X1T6_SALSA B5X1T6_SALSA ----------------------------LKKIDNCWQDHCRQMIMIRSIFLFLDRTYVLQ Q8CHD6_MOUSE Q8CHD6_MOUSE ----------------------------LKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQ Q9CZM5_MOUSE Q9CZM5_MOUSE ----------------------------LKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQ Q99KS9_MOUSE Q99KS9_MOUSE ------------------------------------------MIMIRSIFLFLDRTYVLQ Q8BSL3_MOUSE Q8BSL3_MOUSE ----------------------------LKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQ A2A432_MOUSE A2A432_MOUSE ----------------------------LKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQ Q3TU30_MOUSE Q3TU30_MOUSE ----------------------------LKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQ B3KVX4_HUMAN B3KVX4_HUMAN ----------------------------LKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQ B7Z5K8_HUMAN B7Z5K8_HUMAN ----------------------------LKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQ CUL4B_HUMAN CUL4B_HUMAN ----------------------------LKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQ Q1WF15_FELCA Q1WF15_FELCA ----------------------------LKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQ B1APK5_HUMAN B1APK5_HUMAN ----------------------------LKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQ Q498E8_XENLA Q498E8_XENLA ----------------------------LKKIDKCWKDHCRQMIMIRSIFLFLDRTYVLQ B2GU90_XENTR B2GU90_XENTR ----------------------------LKKIDKCWQDHCRQMIMIRSIFLFLDRTYVLQ B3DLE7_XENTR B3DLE7_XENTR ------------------------------------------------------------ B3DLF2_XENTR B3DLF2_XENTR ------------------------------------------------------------ Q4RTC1_TETNG Q4RTC1_TETNG APRRALPEENRQVLAGPLQANGDVRPPPVTDQFTARLSQYRSGIMIRSIFLFLDRTYVLQ Q4TI50_TETNG Q4TI50_TETNG ------------------------------------------QIMIRSIFLFLDRTYVLQ B3EX44_SORAR B3EX44_SORAR ------------------------------RINTCWQDHCRQMIMIRSIFLFLDRTYVLQ B2RYJ3_RAT B2RYJ3_RAT ----------------------------LKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQ Q8R1T2_MOUSE Q8R1T2_MOUSE ------------------------------------------------------------ CUL4A_MOUSE CUL4A_MOUSE ----------------------------LKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQ Q3UD60_MOUSE Q3UD60_MOUSE ----------------------------LKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQ B4USY1_OTOGA B4USY1_OTOGA ----------------------------LQLARQCLIPEEDERMLARPL----------- B2RBV7_HUMAN B2RBV7_HUMAN ----------------------------LKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQ CUL4A_HUMAN CUL4A_HUMAN ----------------------------LKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQ A8MSH7_HUMAN A8MSH7_HUMAN ----------------------------LKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQ B4DKT2_HUMAN B4DKT2_HUMAN ------------------------------------------------------------ Q4RV94_TETNG Q4RV94_TETNG ----------------------------LGILYKTWSDYLVEITMIEDIFIRMDQIYAKN Q6P0Z1_DANRE Q6P0Z1_DANRE ----------------------------LQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQ Q6TEL5_DANRE Q6TEL5_DANRE ----------------------------LQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQ B3DIU1_DANRE B3DIU1_DANRE ----------------------------LQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQ CUL3_MOUSE CUL3_MOUSE ----------------------------LQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQ Q6ZQ84_MOUSE Q6ZQ84_MOUSE ----------------------------LQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQ B5DF89_RAT B5DF89_RAT ----------------------------LQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQ CUL3_HUMAN CUL3_HUMAN ----------------------------LQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQ Q53S54_HUMAN Q53S54_HUMAN ----------------------------LQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQ B8ZZC3_HUMAN B8ZZC3_HUMAN ----------------------------LQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQ Q4R4A5_MACFA Q4R4A5_MACFA ----------------------------LQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQ B7Z600_HUMAN B7Z600_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????L??????W????????MIR?I????DR?YV?Q

Q1WF16_FELCA Q1WF16_FELCA YLMLSSIWDMGLELFKSYIIGDQNVRSRTIDGILVLIEKERNGEMVDRCLIQRLVTMLSD Q7T2C1_DANRE Q7T2C1_DANRE NSLLPSIWDTGLELFRTHIVSDAAVQSRTVQGILEQVERERSGETVDRSLLRSLLGMLSD Q4SHX5_TETNG Q4SHX5_TETNG NSLLPSIWDTGLELFRTHIVSDSAVQKRTVDGILEQIELERNGETIDRSLLRSLLGMLSD B1H1S6_XENLA B1H1S6_XENLA NSMLPSIWDMGLELFRSHVISDRMVQNKTIDGILKLIEQERSGEAVDRSLLRSLLGMLSD Q08D74_XENTR Q08D74_XENTR NSMLPSIWDMGLELFRCHVVSDRMVQIKTIDGILKLIEQERSGEAVDRSLLRSLLGMLSD Q28FG3_XENTR Q28FG3_XENTR NSMLPSIWDMGLELFRCHVVSDRMVQIKTIDGILKLIEQERSGEAVDRSLLRSLLGMLSD B5X1T6_SALSA B5X1T6_SALSA NSMLPSIWDMGLELFRFYIISDMKVQSKTIYGILLLIERERSGETIDRSLLRSLLSMLSD Q8CHD6_MOUSE Q8CHD6_MOUSE NSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLSMLSD Q9CZM5_MOUSE Q9CZM5_MOUSE NSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLSMLSD Q99KS9_MOUSE Q99KS9_MOUSE NSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLSMLSD Q8BSL3_MOUSE Q8BSL3_MOUSE NSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLSMLSD A2A432_MOUSE A2A432_MOUSE NSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLSMLSD Q3TU30_MOUSE Q3TU30_MOUSE NSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLSMLSD B3KVX4_HUMAN B3KVX4_HUMAN NSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSD B7Z5K8_HUMAN B7Z5K8_HUMAN NSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSD CUL4B_HUMAN CUL4B_HUMAN NSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSD Q1WF15_FELCA Q1WF15_FELCA NSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSD B1APK5_HUMAN B1APK5_HUMAN NSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSD Q498E8_XENLA Q498E8_XENLA NSMLPSIWDMGLELFRTHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSD B2GU90_XENTR B2GU90_XENTR NSMLPSIWDMGLELFRNHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSD B3DLE7_XENTR B3DLE7_XENTR ------------------------------------------------------------ B3DLF2_XENTR B3DLF2_XENTR ------------------------------------------------------------ Q4RTC1_TETNG Q4RTC1_TETNG NSMLPSIWDMGLELFRFYIISDAKVQSKTIDGILLLIGRE-------RSLLRSLLSMLSD Q4TI50_TETNG Q4TI50_TETNG NSMLPSIWDMGLELFRFYIISDAKVQSKTIDGILLLIGRERREEAIDRSLLRSLLSMLSD B3EX44_SORAR B3EX44_SORAR SSMLPSIWDMGLELFRNHIISDKLVQSKTVDGILLLIERERGGEAVDRSLLRSLLSMLSD B2RYJ3_RAT B2RYJ3_RAT NSMLPSIWDMGLELFRNHIISDRMVQSKTIDGILLLIGRERSGEAVDRSLLRSLLSMLSD Q8R1T2_MOUSE Q8R1T2_MOUSE --MLPSIWDMGLELFRNHIISDRMVQSKTIDGILLLIGRERSGEAVDRSLLRSLLSMLSD CUL4A_MOUSE CUL4A_MOUSE NSMLPSIWDMGLELFRNHIISDRMVQSKTIDGILLLIGRERSGEAVDRSLLRSLLSMLSD Q3UD60_MOUSE Q3UD60_MOUSE NSMLPSIWDMGLELFRNHIISDRMVQSKTIDGILLLIGRERSGEAVDRSLLRSLLSMLSD B4USY1_OTOGA B4USY1_OTOGA -----------------------QTDDHDQEHLPVL------GPHLCAAELHASLRL--- B2RBV7_HUMAN B2RBV7_HUMAN NSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSD CUL4A_HUMAN CUL4A_HUMAN NSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSD A8MSH7_HUMAN A8MSH7_HUMAN NSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSD B4DKT2_HUMAN B4DKT2_HUMAN ------------------------------------------------------------ Q4RV94_TETNG Q4RV94_TETNG HG-MDSVFAIGVTLFKEQVLSHSSIKKQLQQLLLGMIDQDRKGELVDRENIRNICKMLMI Q6P0Z1_DANRE Q6P0Z1_DANRE NN-VENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERRGEVVDRGAIRNACQMLMV Q6TEL5_DANRE Q6TEL5_DANRE NN-VENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMV B3DIU1_DANRE B3DIU1_DANRE NN-VENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMI CUL3_MOUSE CUL3_MOUSE NN-VENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMI Q6ZQ84_MOUSE Q6ZQ84_MOUSE NN-VENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMI B5DF89_RAT B5DF89_RAT NN-VENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMI CUL3_HUMAN CUL3_HUMAN NN-VENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMI Q53S54_HUMAN Q53S54_HUMAN NN-VENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMI B8ZZC3_HUMAN B8ZZC3_HUMAN NN-VENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMI Q4R4A5_MACFA Q4R4A5_MACFA NN-VENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMI B7Z600_HUMAN B7Z600_HUMAN ------------------------------------------------------------ MATCH CONSENSUS N?????????GL??FR?????????????????L??I??ER?GE??DR???R????ML??

Q1WF16_FELCA Q1WF16_FELCA L---------------------------RIYQEPFESKFLEETSRFYAAEGRKLVQKKEI Q7T2C1_DANRE Q7T2C1_DANRE L---------------------------QVYKDSFEQRFLSETTRLYAAEGQRLMQERDV Q4SHX5_TETNG Q4SHX5_TETNG L---------------------------QVYKDSFEDRFLTETDRLYAAEGQRLMLERDV B1H1S6_XENLA B1H1S6_XENLA L---------------------------QVYKESFEAKFLEETKCLYAAEGQRLMQEREV Q08D74_XENTR Q08D74_XENTR L---------------------------QVYKESFETKFLEETNCLYAAEGQRLMQEREV Q28FG3_XENTR Q28FG3_XENTR L---------------------------QVYKESFETKFLEETNCLYAAEGQRLMQEREV B5X1T6_SALSA B5X1T6_SALSA L---------------------------QIYQDSFEQRFLEETNRLYAAEGQRLMQEREV Q8CHD6_MOUSE Q8CHD6_MOUSE L---------------------------QIYQDSFEQQFLQETNRLYAAEGQKLMQEREV Q9CZM5_MOUSE Q9CZM5_MOUSE L---------------------------QIYQDSFEQQFLQETNRLYAAEGQKLMQEREV Q99KS9_MOUSE Q99KS9_MOUSE L---------------------------QIYQDSFEQQFLQETNRLYAAEGQKLMQEREV Q8BSL3_MOUSE Q8BSL3_MOUSE L---------------------------QIYQDSFEQQFLQETNRLYAAEGQKLMQEREV A2A432_MOUSE A2A432_MOUSE L---------------------------QIYQDSFEQQFLQETNRLYAAEGQKLMQEREV Q3TU30_MOUSE Q3TU30_MOUSE L---------------------------QIYQDSFEQQFLQETNRLYAAEGQKLMQEREV B3KVX4_HUMAN B3KVX4_HUMAN L---------------------------QIYQDSFEQRFLEETNRLYAAEGQKLMQEREV B7Z5K8_HUMAN B7Z5K8_HUMAN L---------------------------QIYQDSFEQRFLEETNRLYAAEGQKLMQEREV CUL4B_HUMAN CUL4B_HUMAN L---------------------------QIYQDSFEQRFLEETNRLYAAEGQKLMQEREV Q1WF15_FELCA Q1WF15_FELCA L---------------------------QIYQDSFEQRFLEETNRLYAAEGQKLMQEREV B1APK5_HUMAN B1APK5_HUMAN L---------------------------QIYQDSFEQRFLEETNRLYAAEGQKLMQEREV Q498E8_XENLA Q498E8_XENLA L---------------------------QIYQDSFEQRFLEETNRLYSAEGQRLMQEREV B2GU90_XENTR B2GU90_XENTR L---------------------------QIYQDSFEQRFLEETNRLYAAEGQRLMQEREV B3DLE7_XENTR B3DLE7_XENTR ----------------------------------FEQRFLEETNRLYAAEGQRLMQEREV B3DLF2_XENTR B3DLF2_XENTR ----------------------------------FEQRFLEETNRLYAAEGQRLMQEREV Q4RTC1_TETNG Q4RTC1_TETNG LQVAAPLRKLLFFVLQEAALVEASLLSAQIYQESFEQRFLEETNRLYAAEGQRLMQEREV Q4TI50_TETNG Q4TI50_TETNG LQVAAPLRKLLFFVLQEAALVEASLLSAQIYQESFEQRFLEETNRLYAAEGQRLMQEREV B3EX44_SORAR B3EX44_SORAR L---------------------------QVYKDSFEMKFLEETNCLYAAEGQRLMQEREV B2RYJ3_RAT B2RYJ3_RAT L---------------------------QVYKDSFELKFLEETNCLYAAEGQRLMQDREV Q8R1T2_MOUSE Q8R1T2_MOUSE L---------------------------QVYKDSFELKFLEETNCLYAAEGQRLMQDREV CUL4A_MOUSE CUL4A_MOUSE L---------------------------QVYKDSFELKFLEETNCLYAAEGQRLMQDREV Q3UD60_MOUSE Q3UD60_MOUSE L---------------------------QVYKDSFELKFLEETNCLYAAEGQRLMQDREV B4USY1_OTOGA B4USY1_OTOGA -----------------------------VYKDSFEVKFLEETNCLYAAEGQRLMQEREV B2RBV7_HUMAN B2RBV7_HUMAN L---------------------------QVYKDSFELKFLEETNCLYAAEGQRLMQEREV CUL4A_HUMAN CUL4A_HUMAN L---------------------------QVYKDSFELKFLEETNCLYAAEGQRLMQEREV A8MSH7_HUMAN A8MSH7_HUMAN L---------------------------QVYKDSFELKFLEETNCLYAAEGQRLMQEREV B4DKT2_HUMAN B4DKT2_HUMAN ------------------------------------------------------------ Q4RV94_TETNG Q4RV94_TETNG L----------------------SLDGRSLYEEYFEEPFLSRSIKLFQSESRKLLAEKSA Q6P0Z1_DANRE Q6P0Z1_DANRE L----------------------GLEGRSVYEEDFEIPFLDMSAEFFQMESQKFLAENSA Q6TEL5_DANRE Q6TEL5_DANRE L----------------------GLKGRSVYEEDFEIPFLDMSAEFFQMESQKFLAENSA B3DIU1_DANRE B3DIU1_DANRE L----------------------GLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSA CUL3_MOUSE CUL3_MOUSE L----------------------GLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSA Q6ZQ84_MOUSE Q6ZQ84_MOUSE L----------------------GLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSA B5DF89_RAT B5DF89_RAT L----------------------GLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSA CUL3_HUMAN CUL3_HUMAN L----------------------GLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSA Q53S54_HUMAN Q53S54_HUMAN L----------------------GLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSA B8ZZC3_HUMAN B8ZZC3_HUMAN L----------------------GLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSA Q4R4A5_MACFA Q4R4A5_MACFA L----------------------GLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSA B7Z600_HUMAN B7Z600_HUMAN ------------------------------------------------MESQKFLAENSA MATCH CONSENSUS L?????????????????????????????Y???FE??FL?????????E?Q????E???

Q1WF16_FELCA Q1WF16_FELCA PGCPYHIKKLLEGEVDRVRTYLCLNTQKQLITMLEKQLLGEHLSAVLQ---KGLNFLLDE Q7T2C1_DANRE Q7T2C1_DANRE PEYLHHVARRLEEENDRVISYLDQSTQKPLIATVEKQLLGEHMTTILQ---KGLRTLLDE Q4SHX5_TETNG Q4SHX5_TETNG PEYLHHVARRLEEENDRILSYLDQSTQKPLIGCVEKQLLGEHITAILQ---KGLGTLLDE B1H1S6_XENLA B1H1S6_XENLA PEYLHHVNRRLEEEVDRVITYLDHGTHKPLIACVEKQLLGEHLTAILQ---KGLKNMLDE Q08D74_XENTR Q08D74_XENTR PEYLHHVNRRLEEEVDRVITYLDHGTHKPLIACVEKQLLGEHLTAILQ---KGLKNMLDE Q28FG3_XENTR Q28FG3_XENTR PEYLHHVNRRLEEEVDRVITYLDHGTHKPLIACVEKQLLGEHLTAILQ---KGLKNMLDE B5X1T6_SALSA B5X1T6_SALSA PEYLHHVNKRLEEEADRVITYLDQSTQKPLIATVEKQLLGEHLTSTLQ---KGLNHLLDE Q8CHD6_MOUSE Q8CHD6_MOUSE PEYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQ---KGLNSLLDE Q9CZM5_MOUSE Q9CZM5_MOUSE PEYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQ---KGLNSLLDE Q99KS9_MOUSE Q99KS9_MOUSE PEYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQ---KGLNSLLDE Q8BSL3_MOUSE Q8BSL3_MOUSE PEYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQ---KGLNSLLDE A2A432_MOUSE A2A432_MOUSE PEYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQ---KGLNSLLDE Q3TU30_MOUSE Q3TU30_MOUSE PEYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQ---KGLNSLLDE B3KVX4_HUMAN B3KVX4_HUMAN PEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQ---KGLNNLLDE B7Z5K8_HUMAN B7Z5K8_HUMAN PEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQ---KGLNNLLDE CUL4B_HUMAN CUL4B_HUMAN PEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQ---KGLNNLLDE Q1WF15_FELCA Q1WF15_FELCA PEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQ---KGLNNLLDE B1APK5_HUMAN B1APK5_HUMAN PEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQ---KGLNNLLDE Q498E8_XENLA Q498E8_XENLA PEYLHHVNKRLEEEADRVITYLDQSTQKPLIATVEKQLLGEHLTATLQ---KGLNHLLDE B2GU90_XENTR B2GU90_XENTR PEYLHHVNKRLEEEADRVITYLDQSTQKPLIATVEKQLLGEHLTATLQ---KGLNHLLDE B3DLE7_XENTR B3DLE7_XENTR PEYLHHV-KRLEEEADRVITYLDQSTQKPLIATVEKQLLGEHLTATLQ---KGLNHLLDE B3DLF2_XENTR B3DLF2_XENTR PEYLHHV-KRLEEEADRVITYLDQSTQKPLIATVEKQLLGEHLTATLQ---KGLNHLLDE Q4RTC1_TETNG Q4RTC1_TETNG PEYLHHVSKRLEEEADRVITYLDQSTQKPLIASVEKQLLGEHLTATLQ---KGLTHLLDE Q4TI50_TETNG Q4TI50_TETNG PEYLHHVSKRLEEEADRVITYLDQSTQKPLIASVEKQLLGEHLTATLQ---KGLTHLLDE B3EX44_SORAR B3EX44_SORAR -RWSVSVGLVSAEAASRSLYFFNDFIKKPLIACVEKQLLGEHLTAILQ---KGLDHLLDE B2RYJ3_RAT B2RYJ3_RAT PEYLNHVSKRLEEEADRVITYLDHSTQKPLIACVEKQLLGEHLTAILQ---KGLEQLLDE Q8R1T2_MOUSE Q8R1T2_MOUSE PEYLNHVSKRLEEEADRVITYLDHSTQKPLIACVEKQLLGEHLTAILQ---KGLEHLLDE CUL4A_MOUSE CUL4A_MOUSE PEYLNHVSKRLEEEADRVITYLDHSTQKPLIACVEKQLLGEHLTAILQ---KGLEHLLDE Q3UD60_MOUSE Q3UD60_MOUSE PEYLNHVSKRLEEEADRVITYLDHSTQKPLIACVEKQLLGEHLTAILQ---KGLEHLLDE B4USY1_OTOGA B4USY1_OTOGA PEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQ---KGLDHLLDE B2RBV7_HUMAN B2RBV7_HUMAN PEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQ---KGLDHLLDE CUL4A_HUMAN CUL4A_HUMAN PEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQ---KGLDHLLDE A8MSH7_HUMAN A8MSH7_HUMAN PEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQ---KGLDHLLDE B4DKT2_HUMAN B4DKT2_HUMAN ------------------------------------------------------------ Q4RV94_TETNG Q4RV94_TETNG DKYLKEVEDRIEEEEERALSCLDISTGERIIQVVEQEMIVKHMRTIVEMEISGLVHMLEH Q6P0Z1_DANRE Q6P0Z1_DANRE SVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKN Q6TEL5_DANRE Q6TEL5_DANRE SVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKN B3DIU1_DANRE B3DIU1_DANRE SVYIKKVEARINEEIERVIHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKN CUL3_MOUSE CUL3_MOUSE SVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKN Q6ZQ84_MOUSE Q6ZQ84_MOUSE SVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKN B5DF89_RAT B5DF89_RAT SVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKN CUL3_HUMAN CUL3_HUMAN SVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKN Q53S54_HUMAN Q53S54_HUMAN SVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKN B8ZZC3_HUMAN B8ZZC3_HUMAN SVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKN Q4R4A5_MACFA Q4R4A5_MACFA SVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKN B7Z600_HUMAN B7Z600_HUMAN SVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKN MATCH CONSENSUS ??Y???V??R??EE??R????LD??T???????VE??L???H???I??????GL???L??

Q1WF16_FELCA Q1WF16_FELCA NRIEDLSLVYQLFSRIECGFQVLLQHWIEYIKKFGSSIVINPMKDK---TMVQELLDFKD Q7T2C1_DANRE Q7T2C1_DANRE NRVCELTLLYELFSKVKGGLTALLQSWREYIKSVGAETVCSPERDR---EMVQELLDFKD Q4SHX5_TETNG Q4SHX5_TETNG NRVTELTLLYQLFSKVKGGLPTLLQFWRDYIKAFGGEIVCTPEKDK---DMVQDLLDFKD B1H1S6_XENLA B1H1S6_XENLA NRDLELTLMYQLFSRVKDGKMILLQHWGEYIKNFGSGLVVNPEKDK---DMVQELLDFKD Q08D74_XENTR Q08D74_XENTR NRDPELTLMYQLFSRVKGGQIILLQHWGEYIKNFGSGLVINPEKDK---DMVQELLDFKD Q28FG3_XENTR Q28FG3_XENTR NRDPELTLMYQLFSRVKGGQIILLQHWGEYIKNFGSGLVINPEKDK---DMVQELLDFKD B5X1T6_SALSA B5X1T6_SALSA NRIQDLCLLYQLFSRVRGGVLVLLQHWIEYIKAFGSTIVINPEKDK---TMVQELLDFKD Q8CHD6_MOUSE Q8CHD6_MOUSE NRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDK---TMVQELLDFKD Q9CZM5_MOUSE Q9CZM5_MOUSE NRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDK---TMVQELLDFKD Q99KS9_MOUSE Q99KS9_MOUSE NRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDK---TMVQELLDFKD Q8BSL3_MOUSE Q8BSL3_MOUSE NRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDK---TMVQELLDFKD A2A432_MOUSE A2A432_MOUSE NRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDK---TMVQELLDFKD Q3TU30_MOUSE Q3TU30_MOUSE NRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDK---TMVQELLDFKD B3KVX4_HUMAN B3KVX4_HUMAN NRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDK---TMVQELLDFKD B7Z5K8_HUMAN B7Z5K8_HUMAN NRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDK---TMVQELLDFKD CUL4B_HUMAN CUL4B_HUMAN NRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDK---TMVQELLDFKD Q1WF15_FELCA Q1WF15_FELCA NRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDK---TMVQELLDFKD B1APK5_HUMAN B1APK5_HUMAN NRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDK---TMVQELLDFKD Q498E8_XENLA Q498E8_XENLA NRIQDLSLLYQLFSRVRGGVQVLLQHWIEYIKAFGSTIVINPEKDK---TMVQELLDFKD B2GU90_XENTR B2GU90_XENTR NRIQDLSLLYQLFSRVRGGVQVLLQHWIEYIKAFGSTIVINPEKDK---TMVQELLDFKD B3DLE7_XENTR B3DLE7_XENTR NRIQDLSLLYQLFSRVRGGVQVLLQHWIEYIKAFGSTIVINPEKDK---TMVQELLDFKD B3DLF2_XENTR B3DLF2_XENTR NRIQDLSLLYQLFSRVRGGVQVLLQHWIEYIKAFGSTIVINPEKDK---TMVQELLDFKD Q4RTC1_TETNG Q4RTC1_TETNG NRIQDLSLLYQLFSRVRSGVQVLLQHWIEYIKAFGSTIVINPEKDK---TMVQELLDFKD Q4TI50_TETNG Q4TI50_TETNG NRIQDLSLLYQLFSRVRSGVQVLLQHWIEYIKAFGSTIVINPEKDK---TMVQELLDFKD B3EX44_SORAR B3EX44_SORAR NRVPDLTQMYQLFSRVKGGQHVLLQHWSEYIKTFGTTIVINPEKDK---DMVQDLLDFKD B2RYJ3_RAT B2RYJ3_RAT NRVPDLTQMYQLFSRVKGGQHALLQHWSEYIKTFGTTIVINPEKDK---DMVQDLLDFKD Q8R1T2_MOUSE Q8R1T2_MOUSE NRVPDLTQMYQLFSRVKGGQHALLQHWSEYIKTFGTTIVINPEKDK---DMVQDLLDFKD CUL4A_MOUSE CUL4A_MOUSE NRVPDLTQMYQLFSRVKGGQHALLQHWSEYIKTFGTTIVINPEKDK---DMVQDLLDFKD Q3UD60_MOUSE Q3UD60_MOUSE NRVPDLTQMYQLFSRVKGGQHALLQHWSEYIKTFGTTIVINPEKDK---DMVQDLLDFKD B4USY1_OTOGA B4USY1_OTOGA NRVPDLTQMYQLLSRVKGGQQALLRHWSEYIKTFGTTIVINPEKDK---DMVQDLLDFKD B2RBV7_HUMAN B2RBV7_HUMAN NRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDK---DMVQDLLDFKD CUL4A_HUMAN CUL4A_HUMAN NRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDK---DMVQDLLDFKD A8MSH7_HUMAN A8MSH7_HUMAN NRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDK---DMVQDLLDFKD B4DKT2_HUMAN B4DKT2_HUMAN --------MYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDK---DMVQDLLDFKD Q4RV94_TETNG Q4RV94_TETNG TKTQDLARMYRLLGRVPGGLKLMCDCMSSYLRQRGQLLFSQEKAGLNPVDQIQNLLDFKA Q6P0Z1_DANRE Q6P0Z1_DANRE GKTEDLACMYKLFGRVPNGLKTMCECMSWYLREQGKALVSEEGEGKNPVDYIQGLLDLKS Q6TEL5_DANRE Q6TEL5_DANRE GKTEDLACMYKLFGRVPNGLKTMCECMSWYLREQGKALVSEEGEGKNPVDYIQGLLDLKS B3DIU1_DANRE B3DIU1_DANRE GKTEDLACMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKS CUL3_MOUSE CUL3_MOUSE GKTEDLACMYKLFSRVPNGLKTMCECMSCYLREQGKALVSEEGEGKNPVDYIQGLLDLKS Q6ZQ84_MOUSE Q6ZQ84_MOUSE GKTEDLACMYKLFSRVPNGLKTMCECMSCYLREQGKALVSEEGEGKNPVDYIQGLLDLKS B5DF89_RAT B5DF89_RAT GKTEDLACMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKS CUL3_HUMAN CUL3_HUMAN GKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKS Q53S54_HUMAN Q53S54_HUMAN GKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKS B8ZZC3_HUMAN B8ZZC3_HUMAN GKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKS Q4R4A5_MACFA Q4R4A5_MACFA GKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKS B7Z600_HUMAN B7Z600_HUMAN GKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKS MATCH :*.*:.:: * : *:: * . . :* ***:* CONSENSUS ????DL???Y?LFSRV??G??????????Y????G???V??????K??????Q?LLD?K?

Q1WF16_FELCA Q1WF16_FELCA KIDFIIEASFLKNEKIIVAMKDAFETFINKRPNKPAELL--------------------- Q7T2C1_DANRE Q7T2C1_DANRE QMDSVTQSCFQRNESFINAMKEAFENFINQRPNKPAELI--------------------- Q4SHX5_TETNG Q4SHX5_TETNG KMDNVAHCCFARSEGFINAMKEAFETFINKRPNKPAELI--------------------- B1H1S6_XENLA B1H1S6_XENLA KVDHIIEVCFQKNEKFVNTMKESFETFINRRANKPAELI--------------------- Q08D74_XENTR Q08D74_XENTR NVDHIIDVCFQKNEKFVNTMKESFETFINRRANKPAELI--------------------- Q28FG3_XENTR Q28FG3_XENTR NVDHIIDVCFQKNEKFVNTMKESFETFINRRANKPAELI--------------------- B5X1T6_SALSA B5X1T6_SALSA KVDHIIDICFIKNEKFVNAMKEAFETFINKRPNKPAELI--------------------- Q8CHD6_MOUSE Q8CHD6_MOUSE KVDHIIDTCFLKNEKFINAMKEAFETFINKRPNKPAELI--------------------- Q9CZM5_MOUSE Q9CZM5_MOUSE KVDHIIDTCFLENEKFINAMKEAFETFINKRPNKPAELI--------------------- Q99KS9_MOUSE Q99KS9_MOUSE KVDHIIDTCFLKNEKFINAMKEAFETFINKRPNKPAELI--------------------- Q8BSL3_MOUSE Q8BSL3_MOUSE KVDHIIDTCFLKNEKFINAMKEAFETFINKRPNKPAELI--------------------- A2A432_MOUSE A2A432_MOUSE KVDHIIDTCFLKNEKFINAMKEAFETFINKRPNKPAELI--------------------- Q3TU30_MOUSE Q3TU30_MOUSE KVDHIIDTCFLKNEKFINAMKEAFETFINKRPNKPAELI--------------------- B3KVX4_HUMAN B3KVX4_HUMAN KVDHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELI--------------------- B7Z5K8_HUMAN B7Z5K8_HUMAN KVDHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELI--------------------- CUL4B_HUMAN CUL4B_HUMAN KVDHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELI--------------------- Q1WF15_FELCA Q1WF15_FELCA KVDHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELI--------------------- B1APK5_HUMAN B1APK5_HUMAN KVDHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELI--------------------- Q498E8_XENLA Q498E8_XENLA KVDHVIDVCFLKNEKFVNAMKEAFETFINKRPNKPAELI--------------------- B2GU90_XENTR B2GU90_XENTR KVDHVIDVCFLKNEKFVNAMKEAFETFINKRPNKPAELI--------------------- B3DLE7_XENTR B3DLE7_XENTR KVDHVIDVCFLKNEKFVNAMKEAFETFINKRPNKPAELI--------------------- B3DLF2_XENTR B3DLF2_XENTR KVDHVIDVCFLKNEKFVNAMKEAFETFINKRPNKPAELI--------------------- Q4RTC1_TETNG Q4RTC1_TETNG KVDYIIDICFVKNDKFVNAMKEAFETFINKRPNKPAELIGGWRRR--LLLASSPAPSSPS Q4TI50_TETNG Q4TI50_TETNG KVDYIIDICFVKNDKFVNAMKEAFETFINKRPNKPAELIGAGAAVSFFLLPSSPAPSSPS B3EX44_SORAR B3EX44_SORAR RVDHVIDVCFQRSDKCINLMKESFETFINKRPNKPAELI--------------------- B2RYJ3_RAT B2RYJ3_RAT KVDHVVEVCFQRNERFINLMKESFETFINKRPNKPAELI--------------------- Q8R1T2_MOUSE Q8R1T2_MOUSE KVDHVVEVCFQRNERFINLMKESFETFINKRPNKPAELI--------------------- CUL4A_MOUSE CUL4A_MOUSE KVDHVVEVCFQRNERFINLMKESFETFINKRPNKPAELI--------------------- Q3UD60_MOUSE Q3UD60_MOUSE KVDHVVEVCFQRNERFINLMKESFETFINKRPNKPAELI--------------------- B4USY1_OTOGA B4USY1_OTOGA RVDHVIEVCFQRNERFVNLMKESFETFINKRPNKPAELI--------------------- B2RBV7_HUMAN B2RBV7_HUMAN KVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELI--------------------- CUL4A_HUMAN CUL4A_HUMAN KVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELI--------------------- A8MSH7_HUMAN A8MSH7_HUMAN KVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELI--------------------- B4DKT2_HUMAN B4DKT2_HUMAN KVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELI--------------------- Q4RV94_TETNG Q4RV94_TETNG QCDHFLSESFNNNKLCNQTIIGEFEHIFNLNTHSPEYL---------------------- Q6P0Z1_DANRE Q6P0Z1_DANRE RFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSPEYL---------------------- Q6TEL5_DANRE Q6TEL5_DANRE RFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSPEYL---------------------- B3DIU1_DANRE B3DIU1_DANRE RFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSPEYL---------------------- CUL3_MOUSE CUL3_MOUSE RFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSPEYL---------------------- Q6ZQ84_MOUSE Q6ZQ84_MOUSE RFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSPEYL---------------------- B5DF89_RAT B5DF89_RAT RFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSPEYL---------------------- CUL3_HUMAN CUL3_HUMAN RFDRFLLESFNNDRLFKQTIAGDFEYFLNLNSRSPEYL---------------------- Q53S54_HUMAN Q53S54_HUMAN RFDRFLLESFNNDRLFKQTIAGDFEYFLNLNSRSPEYL---------------------- B8ZZC3_HUMAN B8ZZC3_HUMAN RFDRFLLESFNNDRLFKQTIAGDFEYFLNLNSRSPEYL---------------------- Q4R4A5_MACFA Q4R4A5_MACFA RFDRFLLESFNNDRLFKQTIAGDFEYFLNLNSRSPEYL---------------------- B7Z600_HUMAN B7Z600_HUMAN RFDRFLLESFNNDRLFKQTIAGDFEYFLNLNSRSPEYL---------------------- MATCH . * . .* .. : ** ::* ....* * CONSENSUS ??D??????F?????F???????FE?F?N?????P??L??????????????????????

Q1WF16_FELCA Q1WF16_FELCA -------AKYVDSKLRTANKEATDEELEDLLAKVVILFRFIRERDVFEAFYKKDLAKRLL Q7T2C1_DANRE Q7T2C1_DANRE -------AKYVDSKLRAGNKEATEEELERILDKIMIIFRFIHGKDVFEAFYKKDLAKRLL Q4SHX5_TETNG Q4SHX5_TETNG -------AKYVDSKLRAGNKEATEEELERILDKIMIIFRFIHGKDVFEAFYKKDLAKRLL B1H1S6_XENLA B1H1S6_XENLA -------AKYVDSKLRSGNKEATDEELERLLDKIMIIFRFIHGKDVFEAFYKKDLAKRLL Q08D74_XENTR Q08D74_XENTR -------AKYVDSKLRSGNKEATDEELERLLDKIMIIFRFIHGKDVFEAFYKKDLAKRLL Q28FG3_XENTR Q28FG3_XENTR -------AKYVDSKLRSGNKEATDEELERLLDKIMIIFRFIHGKDVFEAFYKKDLAKRLL B5X1T6_SALSA B5X1T6_SALSA -------AKHVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLL Q8CHD6_MOUSE Q8CHD6_MOUSE -------AKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLL Q9CZM5_MOUSE Q9CZM5_MOUSE -------AKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLL Q99KS9_MOUSE Q99KS9_MOUSE -------AKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLL Q8BSL3_MOUSE Q8BSL3_MOUSE -------AKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLL A2A432_MOUSE A2A432_MOUSE -------AKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLL Q3TU30_MOUSE Q3TU30_MOUSE -------AKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLL B3KVX4_HUMAN B3KVX4_HUMAN -------AKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLL B7Z5K8_HUMAN B7Z5K8_HUMAN -------AKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLL CUL4B_HUMAN CUL4B_HUMAN -------AKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLL Q1WF15_FELCA Q1WF15_FELCA -------AKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLL B1APK5_HUMAN B1APK5_HUMAN -------AKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLL Q498E8_XENLA Q498E8_XENLA -------AKHVDSKLRTGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLL B2GU90_XENTR B2GU90_XENTR -------AKYVDSKLRTGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLL B3DLE7_XENTR B3DLE7_XENTR -------AKYVDSKLRTGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLL B3DLF2_XENTR B3DLF2_XENTR -------AKYVDSKLRTGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLL Q4RTC1_TETNG Q4RTC1_TETNG NSLLSVPAKHVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLL Q4TI50_TETNG Q4TI50_TETNG NSLLSVPAKHVDSKLRAGNKEATDEELEKMLDKIMIIFRFIY------------------ B3EX44_SORAR B3EX44_SORAR -------AKHVDSKLRAGNKEATDEELERILDKIMIIFRFIHGKDVFEAFYKKDLAKRLL B2RYJ3_RAT B2RYJ3_RAT -------AKHVDSKLRAGNKEATDEELERILDKIMILFRFIHGKDVFEAFYKKDLAKRLL Q8R1T2_MOUSE Q8R1T2_MOUSE -------AKHVDSKLRAGNKEATDEELERILDKIMILFRFIHGKDVFEAFYKKDLAKRLL CUL4A_MOUSE CUL4A_MOUSE -------AKHVDSKLRAGNKEATDEELERILDKIMILFRFIHGKDVFEAFYKKDLAKRLL Q3UD60_MOUSE Q3UD60_MOUSE -------AKHVDSKLRAGNKEATDEELERIL----------------------------- B4USY1_OTOGA B4USY1_OTOGA -------AKHVDSKLRAGNKEATDEELERTLDKIMIIFRFIHGKDVFEAFYKKDLAKRLL B2RBV7_HUMAN B2RBV7_HUMAN -------AKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLL CUL4A_HUMAN CUL4A_HUMAN -------AKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLL A8MSH7_HUMAN A8MSH7_HUMAN -------AKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLL B4DKT2_HUMAN B4DKT2_HUMAN -------AKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLL Q4RV94_TETNG Q4RV94_TETNG -------SLFIHDKLTKGTKCLTEQEVESYLDKALMLFKILQEKDMFEKYYKQHLSYRLL Q6P0Z1_DANRE Q6P0Z1_DANRE -------SLFIDDKLKKGVKGLTEQEVESILDKAMVLFRFMQEKDVFERYYKQHLARRLL Q6TEL5_DANRE Q6TEL5_DANRE -------SLFIDDKLKKGVKGLTEQEVESILDKAMVLFRFMQEKDVFERYYKQHLARRLL B3DIU1_DANRE B3DIU1_DANRE -------SLFIDDKLKKGVKGLTEQEVESILDKAMVLFRFMQEKDVFERYYKQHLARRLL CUL3_MOUSE CUL3_MOUSE -------SLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLL Q6ZQ84_MOUSE Q6ZQ84_MOUSE -------SLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLL B5DF89_RAT B5DF89_RAT -------SLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLL CUL3_HUMAN CUL3_HUMAN -------SLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLL Q53S54_HUMAN Q53S54_HUMAN -------SLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLL B8ZZC3_HUMAN B8ZZC3_HUMAN -------SLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLL Q4R4A5_MACFA Q4R4A5_MACFA -------SLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLL B7Z600_HUMAN B7Z600_HUMAN -------SLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLL MATCH : .:..** . * *::*:* * CONSENSUS ???????????D?KL??G?K??T??E?E??LDK?M??FRF???KDVFE??YK??LA?RLL

Q1WF16_FELCA Q1WF16_FELCA LDKSASVDAEKSMLCKLKQECGTAFTNKLQGMVKDMELSKDIMIQ-----YMKNQNIP-G Q7T2C1_DANRE Q7T2C1_DANRE VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQ--YMQNQTEP-S Q4SHX5_TETNG Q4SHX5_TETNG VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQ--YMQNQSEP-S B1H1S6_XENLA B1H1S6_XENLA VGKSASVDSEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDVMVQFKQ--HMQNHSDP-G Q08D74_XENTR Q08D74_XENTR VGKSASVDSEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDVMVQFKQ--HMQNHSDP-G Q28FG3_XENTR Q28FG3_XENTR VGKSASVDSEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDVMVQFKQ--HMQNHSDP-G B5X1T6_SALSA B5X1T6_SALSA VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVQFKQ-----CQNIP-G Q8CHD6_MOUSE Q8CHD6_MOUSE VGKSASVDAEKSMLSKLKH-------------------------------YMQNQNVP-G Q9CZM5_MOUSE Q9CZM5_MOUSE VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQ--YMQNQNVP-G Q99KS9_MOUSE Q99KS9_MOUSE VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQ--YMQNQNVP-G Q8BSL3_MOUSE Q8BSL3_MOUSE VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQ--YMQNQNVP-G A2A432_MOUSE A2A432_MOUSE VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQ--YMQNQNVP-G Q3TU30_MOUSE Q3TU30_MOUSE VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQ--YMQNQNVP-G B3KVX4_HUMAN B3KVX4_HUMAN VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQ--YMQNQNVP-G B7Z5K8_HUMAN B7Z5K8_HUMAN VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQ--YMQNQNVP-G CUL4B_HUMAN CUL4B_HUMAN VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQ--YMQNQNVP-G Q1WF15_FELCA Q1WF15_FELCA VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQVKYMQNQNVP-G B1APK5_HUMAN B1APK5_HUMAN VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQ--YMQNQNVP-G Q498E8_XENLA Q498E8_XENLA VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQ--YMQNQNVP-G B2GU90_XENTR B2GU90_XENTR VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQ--YMQNQNVP-G B3DLE7_XENTR B3DLE7_XENTR VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQ--YMQNQNVP-G B3DLF2_XENTR B3DLF2_XENTR VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQ--YMQNQNVP-G Q4RTC1_TETNG Q4RTC1_TETNG VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVQFKQ--YMQCQNIP-G Q4TI50_TETNG Q4TI50_TETNG ------------------------------------------------------------ B3EX44_SORAR B3EX44_SORAR VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQ--YMQNQSAP-S B2RYJ3_RAT B2RYJ3_RAT VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQ--HMQNQSAP-G Q8R1T2_MOUSE Q8R1T2_MOUSE VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQ--HMQNQSAP-G CUL4A_MOUSE CUL4A_MOUSE VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQ--HMQNQSAP-G Q3UD60_MOUSE Q3UD60_MOUSE ------------------------------------------------------------ B4USY1_OTOGA B4USY1_OTOGA VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQ--HMQNQSDP-G B2RBV7_HUMAN B2RBV7_HUMAN VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQ--HMQNQSDS-G CUL4A_HUMAN CUL4A_HUMAN VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQ--HMQNQSDS-G A8MSH7_HUMAN A8MSH7_HUMAN VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQ--HMQNQSDS-G B4DKT2_HUMAN B4DKT2_HUMAN VGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQ--HMQNQSDS-G Q4RV94_TETNG Q4RV94_TETNG SNMSVSEHTEKSMILRLKRECGFQFTAKLEGMFKDMSISTTTMEEFLS--HIQTVPISLS Q6P0Z1_DANRE Q6P0Z1_DANRE TNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRH--HLQTSQVSLC Q6TEL5_DANRE Q6TEL5_DANRE TNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRH--HLQTSQVSLC B3DIU1_DANRE B3DIU1_DANRE TNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQ--HLTSTGVSLG CUL3_MOUSE CUL3_MOUSE TNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQ--HLQATGVSLG Q6ZQ84_MOUSE Q6ZQ84_MOUSE TNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQ--HLQATGVSLG B5DF89_RAT B5DF89_RAT TNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQ--HLQATGVSLG CUL3_HUMAN CUL3_HUMAN TNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQ--HLQATGVSLG Q53S54_HUMAN Q53S54_HUMAN TNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQ--HLQATGVSLG B8ZZC3_HUMAN B8ZZC3_HUMAN TNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQ--HLQATGVSLG Q4R4A5_MACFA Q4R4A5_MACFA TNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQ--HLQATGVSLG B7Z600_HUMAN B7Z600_HUMAN TNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQ--HLQATGVSLG MATCH CONSENSUS ??KS?S?D?EK?M?SKLK?ECG??FTSKLEGMF?DM??S???M??F?Q????Q??????G

Q1WF16_FELCA Q1WF16_FELCA NIDLTVNILTMSFWPAYISK-EIHLPPD------------MERLQKNFKNFYLSKHSGRK Q7T2C1_DANRE Q7T2C1_DANRE NIELTVNILTMGYWPSYTPM-DVHLPAE------------MVKLQEVFKLFYLGKHSGRK Q4SHX5_TETNG Q4SHX5_TETNG NIELTVNILTMGYWPSYTPM-EVHLPTE------------MVKLQEVFKMFYLGKHSGRK B1H1S6_XENLA B1H1S6_XENLA NIDLTVNILTMGYWPSYTPM-DVHLPAE------------MVKLQEIFKTFYLGKHSGRR Q08D74_XENTR Q08D74_XENTR NIDLTVNILTMGYWPTYTPV-DVHLPAE------------MVKLQEIFKTFYLGKHSGRR Q28FG3_XENTR Q28FG3_XENTR NIDLTVNILTMGYWPTYTPV-DVHLPAE------------MVKLQEIFKAFYLGKHSGRR B5X1T6_SALSA B5X1T6_SALSA NIELTVNILTMGYWPTYIPM-EVHLPAE-------------VTNIEPFRLFC-------- Q8CHD6_MOUSE Q8CHD6_MOUSE NIELTVNILTMGYWPTYVPM-EVHLPPE------------MVKLQEIFKTFYLGKHSGRK Q9CZM5_MOUSE Q9CZM5_MOUSE NIELTVNILTMGYWPTYVPM-EVHLPPE------------MVKLQEIFKTFYLGKHSGRK Q99KS9_MOUSE Q99KS9_MOUSE NIELTVNILTMGYWPTYVPM-EVHLPPE------------MVKLQEIFKTFYLGKHSGRK Q8BSL3_MOUSE Q8BSL3_MOUSE NIELTVNILTMGYWPTYVPM-EVHLPPE------------MVKLQEIFKTFYLGKHSGRK A2A432_MOUSE A2A432_MOUSE NIELTVNILTMGYWPTYVPM-EVHLPPE------------MVKLQEIFKTFYLGKHSGRK Q3TU30_MOUSE Q3TU30_MOUSE NIELTVNILTMGYWPTYVPM-EVHLPPE------------MVKLQEIFKTFYLGKHSGRK B3KVX4_HUMAN B3KVX4_HUMAN NIELTVNILTMGYWPTYVPM-EVHLPPE------------MVKLQEIFKTFYLGKHSGRK B7Z5K8_HUMAN B7Z5K8_HUMAN NIELTVNILTMGYWPTYVPM-EVHLPPE------------MVKLQEIFKTFYLGKHSGRK CUL4B_HUMAN CUL4B_HUMAN NIELTVNILTMGYWPTYVPM-EVHLPPE------------MVKLQEIFKTFYLGKHSGRK Q1WF15_FELCA Q1WF15_FELCA NIELTVNILTMGYWPTYVPM-EVHLPPE------------MVKLQEIFKTFYLGKHSGRK B1APK5_HUMAN B1APK5_HUMAN NIELTVNILTMGYWPTYVPM-EVHLPPE------------MVKLQEIFKTFYLGKHSGRK Q498E8_XENLA Q498E8_XENLA NIELTVNILTMGYWPTYVPM-EVLLPPE------------MVKLQEIFKTFYLGKHSGRK B2GU90_XENTR B2GU90_XENTR NIELTVNILTMGYWPTYVPM-EVHLPPE------------MVKLQEIFKTFYLGKHSGRK B3DLE7_XENTR B3DLE7_XENTR NIELTVNILTMGYWPTYVPM-EVHLPPE------------MVKLQEIFKTFYLGKHSGRK B3DLF2_XENTR B3DLF2_XENTR NIELTVNILTMGYWPTYVPM-EVHLPPE------------MVKLQEIFKTFYLGKHSGRK Q4RTC1_TETNG Q4RTC1_TETNG NIELTVNILTMGYWPTYVPM-EVHLPPERPRNENCVIANQMVRLQEIFKTFYLGKHSGRK Q4TI50_TETNG Q4TI50_TETNG ------------------------------------------------------------ B3EX44_SORAR B3EX44_SORAR PIDLTVNILTMGYWPTYTPM-EVHLPPE------------MVKLQEVFKTFYLGKHSGRK B2RYJ3_RAT B2RYJ3_RAT PIDLTVNILTMGYWPTYTPM-EVHLPPE------------MVRLQEVFKTFYLGKHSGRK Q8R1T2_MOUSE Q8R1T2_MOUSE PIDLTVNILTMGYWPTYTPM-EVHLPPE------------MVRLQEVFKTFYLGKHSGRK CUL4A_MOUSE CUL4A_MOUSE PIDLTVNILTMGYWPTYTPM-EVHLPPE------------MVRLQEVFKTFYLGKHSGRK Q3UD60_MOUSE Q3UD60_MOUSE ------------------------------------------------------------ B4USY1_OTOGA B4USY1_OTOGA PIDLTVNILTMGYWPTYTPM-EVHLTPE------------MIKLQEVFKTFYLGKHSGRK B2RBV7_HUMAN B2RBV7_HUMAN PIDLTVNILTMGYWPTYTPM-EVHLTPE------------MIKLQEVFKAFYLGKHSGRK CUL4A_HUMAN CUL4A_HUMAN PIDLTVNILTMGYWPTYTPM-EVHLTPE------------MIKLQEVFKAFYLGKHSGRK A8MSH7_HUMAN A8MSH7_HUMAN PIDLTVNILTMGYWPTYTPM-EVHLTPE------------MIKLQEVFKAFYLGKHSGRK B4DKT2_HUMAN B4DKT2_HUMAN PIDLTVNILTMGYWPTYTPM-EVHLTPE------------MIKLQEVFKAFYLGKHSGRK Q4RV94_TETNG Q4RV94_TETNG GLNLTVKVLTSGVWPTQPQAPKCSIPSI------------PSTAFEVFRSFYLAKHNGRQ Q6P0Z1_DANRE Q6P0Z1_DANRE GVDLTVRVLTTGYWPTQSATPKCNIPPS------------PRHAFEVFRRFYLAKHSGRQ Q6TEL5_DANRE Q6TEL5_DANRE GVDLTVRVLTTGYWPTQSATPKCNIPPS------------PRHAFEVFRRFYLAKHSGRQ B3DIU1_DANRE B3DIU1_DANRE GVDLIVRVLTTGYWPTQSATPKCNIPPS------------PRHAFEVFRRFYLAKHSGRQ CUL3_MOUSE CUL3_MOUSE GVDLTVRVLTTGYWPTQSATPKCNIPPA------------PRHAFEIFRRFYLAKHSGRQ Q6ZQ84_MOUSE Q6ZQ84_MOUSE GVDLTVRVLTTGYWPTQSATPKCNIPPA------------PRHAFEIFRRFYLAKHSGRQ B5DF89_RAT B5DF89_RAT GVDLTVRVLTTGYWPTQSATPKCNIPPA------------PRHAFEIFRRFYLAKHSGRQ CUL3_HUMAN CUL3_HUMAN GVDLTVRVLTTGYWPTQSATPKCNIPPA------------PRHAFEIFRRFYLAKHSGRQ Q53S54_HUMAN Q53S54_HUMAN GVDLTVRVLTTGYWPTQSATPKCNIPPA------------PRHAFEIFRRFYLAKHSGRQ B8ZZC3_HUMAN B8ZZC3_HUMAN GVDLTVRVLTTGYWPTQSATPKCNIPPA------------PRHAFEIFRRFYLAKHSGRQ Q4R4A5_MACFA Q4R4A5_MACFA GVDLTVRVLTTGYWPTQSATPKCNIPPA------------PRHAFEIFRRFYLAKHSGRQ B7Z600_HUMAN B7Z600_HUMAN GVDLTVRVLTTGYWPTQSATPKCNIPPA------------PRHAFEIFRRFYLAKHSGRQ MATCH CONSENSUS ???LTV??LT?GYWPT?????????PP??????????????????E?F??FYL?KHSGR?

Q1WF16_FELCA Q1WF16_FELCA LQWQSTLGRCVLRAEFKK---------------------------------GKKELQVTL Q7T2C1_DANRE Q7T2C1_DANRE LQWQPTLGHAVLKTEFKE---------------------------------GKKELQVSL Q4SHX5_TETNG Q4SHX5_TETNG LQWQSTLGHAVLKAEFKE---------------------------------GKKELQVSL B1H1S6_XENLA B1H1S6_XENLA LQWQSTLGHAVLKADFKE---------------------------------EKKELQVSL Q08D74_XENTR Q08D74_XENTR LQWQSTLGHAVLKADFKE---------------------------------EKKELQVSL Q28FG3_XENTR Q28FG3_XENTR LQWQSTLGHAVLKADFKE---------------------------------EKKELQVSL B5X1T6_SALSA B5X1T6_SALSA ------------------------------------------------------------ Q8CHD6_MOUSE Q8CHD6_MOUSE LQWQSTLGHCVLKAEFKE---------------------------------GKKELQVSL Q9CZM5_MOUSE Q9CZM5_MOUSE LQWQSTLGHCVLKAEFKE---------------------------------GKKELQVSL Q99KS9_MOUSE Q99KS9_MOUSE LQWQSTLGHCVLKAEFKE---------------------------------GKKELQVSL Q8BSL3_MOUSE Q8BSL3_MOUSE LQWQSTLGHCVLKAEFKE---------------------------------GKKELQVSL A2A432_MOUSE A2A432_MOUSE LQWQSTLGHCVLKAEFKE---------------------------------GKKELQVSL Q3TU30_MOUSE Q3TU30_MOUSE LQWQSTLGHCVLKAEFKE---------------------------------GKKELQVSL B3KVX4_HUMAN B3KVX4_HUMAN LQWQSTLGHCVLKAEFKE---------------------------------GKKELQVSL B7Z5K8_HUMAN B7Z5K8_HUMAN LQWQSTLGHCVLKAEFKE---------------------------------GKKELQVSL CUL4B_HUMAN CUL4B_HUMAN LQWQSTLGHCVLKAEFKE---------------------------------GKKELQVSL Q1WF15_FELCA Q1WF15_FELCA LQWQSTLGHCVLKAEFKE---------------------------------GKKELQVSL B1APK5_HUMAN B1APK5_HUMAN LQWQSTLGHCVLKAEFKE---------------------------------GKKELQVSL Q498E8_XENLA Q498E8_XENLA LQWQSTLGQCVLKAEFNE---------------------------------GRKELQVSL B2GU90_XENTR B2GU90_XENTR LQWQSTLGQCVLKAEFNE---------------------------------GKKELQVSL B3DLE7_XENTR B3DLE7_XENTR LQWQSTLGQCVLKAEFNE---------------------------------GKKELQVSL B3DLF2_XENTR B3DLF2_XENTR LQWQSTLGQCVLKAEFNE---------------------------------GKKELQVSL Q4RTC1_TETNG Q4RTC1_TETNG LQWQSTLGHCVLKAEFKEVDDRLLIPLRVYSLSSVKIILFFFIPFPKKKKKGKKELQVSL Q4TI50_TETNG Q4TI50_TETNG ------------------------------------------------------------ B3EX44_SORAR B3EX44_SORAR LQWQTTLGHAVLKAEFKE---------------------------------GKKEFQVSL B2RYJ3_RAT B2RYJ3_RAT LQWQTTLGHAVLKADFKE---------------------------------GKKEFQVSL Q8R1T2_MOUSE Q8R1T2_MOUSE LQWQTTLGHAVLKADFKE---------------------------------GKKEFQVSL CUL4A_MOUSE CUL4A_MOUSE LQWQTTLGHAVLKADFKE---------------------------------GKKEFQVSL Q3UD60_MOUSE Q3UD60_MOUSE ------------------------------------------------------------ B4USY1_OTOGA B4USY1_OTOGA LQWQTTLGHAVLKAEFKE---------------------------------GKKEFQVSL B2RBV7_HUMAN B2RBV7_HUMAN LQWQTTLGHAVLKAEFKE---------------------------------GKKEFQVSL CUL4A_HUMAN CUL4A_HUMAN LQWQTTLGHAVLKAEFKE---------------------------------GKKEFQVSL A8MSH7_HUMAN A8MSH7_HUMAN LQWQTTLGHAVLKAEFKE---------------------------------GKKEFQVSL B4DKT2_HUMAN B4DKT2_HUMAN LQWQTTLGHAVLKAEFKE---------------------------------GKKEFQVSL Q4RV94_TETNG Q4RV94_TETNG LMLQYHMGWADVNATFYGSLQKVNDPESNAGGAQV-----------T----RKHILQVST Q6P0Z1_DANRE Q6P0Z1_DANRE LTLQHHMGSADLNATFYGPIKKEDGSDVGVGGALL-----------TGSNTRKHILQVST Q6TEL5_DANRE Q6TEL5_DANRE LTLQHHMGSADLNATFYGPIKKEDGSDVGVGGALL-----------TGSNTRKHILQVST B3DIU1_DANRE B3DIU1_DANRE LTLQHHMGSADLNATFYGPIKKEDGSDM-VGGAQV-----------TGSNTRKHILQVST CUL3_MOUSE CUL3_MOUSE LTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQV-----------TGSNTRKHILQVST Q6ZQ84_MOUSE Q6ZQ84_MOUSE LTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQV-----------TGSNTRKHILQVST B5DF89_RAT B5DF89_RAT LTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQV-----------TGSNTRKHILQVST CUL3_HUMAN CUL3_HUMAN LTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQV-----------TGSNTRKHILQVST Q53S54_HUMAN Q53S54_HUMAN LTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQV-----------TGSNTRKHILQVST B8ZZC3_HUMAN B8ZZC3_HUMAN LTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQV-----------TGSNTRKHILQVST Q4R4A5_MACFA Q4R4A5_MACFA LTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQV-----------TGSNTRKHILQVST B7Z600_HUMAN B7Z600_HUMAN LTLQHHMGSADLNATFYGPIKKEDGSEVGVGGAQV-----------TGSNTRKHILQVST MATCH CONSENSUS L??Q???G???L?A?F????????????????????????????????????K???QVS?

Q1WF16_FELCA Q1WF16_FELCA FQTLVLLMFNEGNRFSLEEIKVATGVEDRELRRTLQSLACGRA--RVLIKSPKGRDVEDG Q7T2C1_DANRE Q7T2C1_DANRE FQTLVLLMFNESDECSVEEIRVATGIEEGELKRTLQSLACGKA--RVLNKTPRGKEVED- Q4SHX5_TETNG Q4SHX5_TETNG FQTLVLLMFNEGEEFSVEEIGTATGIENGELRRTLQSLACGKA--RVLNKNPRGKDVEDG B1H1S6_XENLA B1H1S6_XENLA FQTLVLLLFNKGEEFGFEEIKITTGIEDNELRRTLQSLACGKA--RVLNKSQKKKKK--- Q08D74_XENTR Q08D74_XENTR FQTLVLLLFNKGDEFGFEEIKITTGIEDNELRRTLQSLACGKA--RVLNKSPKSKDVEDG Q28FG3_XENTR Q28FG3_XENTR FQTLVLLLFNKGDEFGFEEIKITTGIEDNELRRTLQSLACGKA--RVLNKSPKSKDVEDG B5X1T6_SALSA B5X1T6_SALSA ------------------------------------------------------------ Q8CHD6_MOUSE Q8CHD6_MOUSE FQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKA--RVLAKNPKGKDIEDG Q9CZM5_MOUSE Q9CZM5_MOUSE FQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKA--RVLAKNPKGKDIEDG Q99KS9_MOUSE Q99KS9_MOUSE FQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKA--RVLAKNPKGKDIEDG Q8BSL3_MOUSE Q8BSL3_MOUSE FQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKA--RVLAKNPKGKDIEDG A2A432_MOUSE A2A432_MOUSE FQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKA--RVLAKNPKGKDIEDG Q3TU30_MOUSE Q3TU30_MOUSE FQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKA--RVLAKNPKGKDIEDG B3KVX4_HUMAN B3KVX4_HUMAN FQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKA--RVLAKNPKGKDIEDG B7Z5K8_HUMAN B7Z5K8_HUMAN FQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKA--RVLAKNPKGKDIEDG CUL4B_HUMAN CUL4B_HUMAN FQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKA--RVLAKNPKGKDIEDG Q1WF15_FELCA Q1WF15_FELCA FQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKA--RVLAKNPKGKDIEDG B1APK5_HUMAN B1APK5_HUMAN FQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKA--RVLAKNPKGKDIEDG Q498E8_XENLA Q498E8_XENLA FQTLVLLMFNEGDEFSLEEIRQATGIEDSELRRTLQSLACGRA--RVLVKNPKSKDVDDG B2GU90_XENTR B2GU90_XENTR FQTLVLLMFNEGDEFSLEEIRQATGIEDSELRRTLQSLACGRA--RVLVKSPKSKDVDDG B3DLE7_XENTR B3DLE7_XENTR FQTLVLLMFNEGDEFSLEEIRQATGIEDSELRRTLQSLACGRA--RVLVKSPKSKDVDDG B3DLF2_XENTR B3DLF2_XENTR FQTLVLLMFNEGDEFSLEEIRQATGIEDSELRRTLQSLACGRA--RVLVKSPKSKDVDDG Q4RTC1_TETNG Q4RTC1_TETNG FQTLVLLMFNEGEEFTLEEIKLATGIEDSELRRTLQSLACGKA--RVLTKLPKSKDVEDG Q4TI50_TETNG Q4TI50_TETNG ------------------------------------------------------------ B3EX44_SORAR B3EX44_SORAR FQTLVLLMFNEGDGFSFEEIKVATGIEDSELRRTLQSLACGKA--RVLVKSPKGKEVEDG B2RYJ3_RAT B2RYJ3_RAT FQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKA--RVLIKSPKGKEVEDG Q8R1T2_MOUSE Q8R1T2_MOUSE FQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKA--RVLIKSPKGKEVEDG CUL4A_MOUSE CUL4A_MOUSE FQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKA--RVLIKSPKGKEVEDG Q3UD60_MOUSE Q3UD60_MOUSE ------------------------------------------------------------ B4USY1_OTOGA B4USY1_OTOGA FQTLVLLMFNEGDEFSFEEIKMATGIEDSELRRTLQSLACGKA--RVLTKSPKGKEVEDA B2RBV7_HUMAN B2RBV7_HUMAN FQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKA--RVLIKSPKGKEVEDG CUL4A_HUMAN CUL4A_HUMAN FQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKA--RVLIKSPKGKEVEDG A8MSH7_HUMAN A8MSH7_HUMAN FQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKA--RVLIKSPKGKEVEDG B4DKT2_HUMAN B4DKT2_HUMAN FQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKA--RVLIKSPKGKEVEDG Q4RV94_TETNG Q4RV94_TETNG FQMTILMLFNNRETFTFKEIQQETDIPDNDLLRALLPLYWGKPSQRVLVKEPDCKQIKKE Q6P0Z1_DANRE Q6P0Z1_DANRE FQMTILMLFNNREKFTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIESG Q6TEL5_DANRE Q6TEL5_DANRE FQMTILMLFNNREKFTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIESG B3DIU1_DANRE B3DIU1_DANRE FQMTILMLFNNREKSTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENG CUL3_MOUSE CUL3_MOUSE FQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIESG Q6ZQ84_MOUSE Q6ZQ84_MOUSE FQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIESG B5DF89_RAT B5DF89_RAT FQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIESG CUL3_HUMAN CUL3_HUMAN FQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENG Q53S54_HUMAN Q53S54_HUMAN FQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENG B8ZZC3_HUMAN B8ZZC3_HUMAN FQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENG Q4R4A5_MACFA Q4R4A5_MACFA FQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENG B7Z600_HUMAN B7Z600_HUMAN FQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENG MATCH CONSENSUS FQ???L??FN???????EEI???T?I???EL?R?LQSLACGK???RVL?K?PK?K??E?G

Q1WF16_FELCA Q1WF16_FELCA DVFFCNEEFRHKLFKIKINQIQMK--ETIEER--TITTQRVFQDRRYQIDAAIVRIMKMR Q7T2C1_DANRE Q7T2C1_DANRE ------------------------------------------------------------ Q4SHX5_TETNG Q4SHX5_TETNG DRFNFNNEFKHKLFRIKINQIQMK--ETVEEQ--VSTTERVFQDRQYQIDAAVVRIMKMR B1H1S6_XENLA B1H1S6_XENLA ------------------------------------------------------------ Q08D74_XENTR Q08D74_XENTR DRFCFNADFKHKLYRIKINQIQMK--ETVEEQ--VNTTERVFQDRQYQIDAAIVRIMKMR Q28FG3_XENTR Q28FG3_XENTR DRFCFNADFKHKLYRIKINQIQMK--ETVEEQ--VNTTERVFQDRQYQIDAAIVRIMKMR B5X1T6_SALSA B5X1T6_SALSA ------------------------------------------------------------ Q8CHD6_MOUSE Q8CHD6_MOUSE DKFICNDDFKHKLFRIKINQIQMK--ETVEEQ--ASTTERVFQDRQYQIDAAIVRIMKMR Q9CZM5_MOUSE Q9CZM5_MOUSE DKFICNDDFKHKLFRIKINQIQMK--ETVEEQ--ASTTERVFQDRQYQIDAAIVRIMKMR Q99KS9_MOUSE Q99KS9_MOUSE DKFICNDDFKHKLFRIKINQIQMK--ETVEEQ--ASTTERVFQDRQYQIDAAIVRIMKMR Q8BSL3_MOUSE Q8BSL3_MOUSE DKFICNDDFKHKLFRIKINQIQMK--ETVEEQ--ASTTERVFQDRQYQIDAAIVRIMKMR A2A432_MOUSE A2A432_MOUSE DKFICNDDFKHKLFRIKINQIQMK--ETVEEQ--ASTTERVFQDRQYQIDAAIVRIMKMR Q3TU30_MOUSE Q3TU30_MOUSE DKFICNDDFKHKLFRIKINQIQMK--ETVEEQ--ASTTERVFQDRQYQIDAAIVRIMKMR B3KVX4_HUMAN B3KVX4_HUMAN DKFICNDDFKHKLFRIKINQIQMK--ETVEEQ--ASTTERVFQDRQYQIDAAIVRIMKMR B7Z5K8_HUMAN B7Z5K8_HUMAN DKFICNDDFKHKLFRIKINQIQMK--ETVEEQ--ASTTERVFQDRQYQIDAAIVRIMKMR CUL4B_HUMAN CUL4B_HUMAN DKFICNDDFKHKLFRIKINQIQMK--ETVEEQ--ASTTERVFQDRQYQIDAAIVRIMKMR Q1WF15_FELCA Q1WF15_FELCA DKFICNDDFKHKLFRIKINQIQMK--ETVEEQ--ASTTERVFQDRQYQIDAAIVRIMKMR B1APK5_HUMAN B1APK5_HUMAN DKFICNDDFKHKLFRIKINQIQMK--ETVEEQ--ASTTERVFQDRQYQIDAAIVRIMKMR Q498E8_XENLA Q498E8_XENLA DKFTFNDDFRHQLFRIRINQIQMK--ETVEEQ--ASTTERVFQDRQYQIDAAIVRIMKMR B2GU90_XENTR B2GU90_XENTR DKFTFNDDFRHQLFRIRINQIQMK--ETVEEQ--ASTTERVFQDRQYQIDAAIVRIMKMR B3DLE7_XENTR B3DLE7_XENTR DKFTFNDDFRHQLFRIRINQIQMK--ETVEEQ--ASTTERVFQDRQYQIDAAIVRIMKMR B3DLF2_XENTR B3DLF2_XENTR DKFTFNDDFRHQLFRIRINQIQMK--ETVEEQ--ASTTERVFQDRQYQIDAAIVRIMKMR Q4RTC1_TETNG Q4RTC1_TETNG DKFSCNDDFKHKLFRIKINQIQMK--ETVEEQ--ASTTERVFQDRQYQIDAAIVRIMKMR Q4TI50_TETNG Q4TI50_TETNG ------------------------------------------------------------ B3EX44_SORAR B3EX44_SORAR DKFLFNGEFKHKLFRIKINQIQMR--ETVEEQ--VSTTERVFQDRQYQIDAAIVRTMKMR B2RYJ3_RAT B2RYJ3_RAT DKFIFNADFKHKLFRIKINQIQMK--ETVEEQ--VSTTERVFQDRQYQIDAAIVRIMKMR Q8R1T2_MOUSE Q8R1T2_MOUSE DKFIFNADFKHKLFRIKINQIQMK--ETVEEQ--VSTTERVFQDRQYQIDAAIVRIMKMR CUL4A_MOUSE CUL4A_MOUSE DKFIFNADFKHKLFRIKINQIQMK--ETVEEQ--VSTTERVFQDRQYQIDAAIVRIMKMR Q3UD60_MOUSE Q3UD60_MOUSE ------------------------------------------------------------ B4USY1_OTOGA B4USY1_OTOGA DKFIFNGDFKHKLFRIKINQIQMK--ETVEEQ--VSTTERVFQDRQYQIDAAIVRIMKMR B2RBV7_HUMAN B2RBV7_HUMAN DKFIFNGEFKHKLFRIKINQIQMK--ETVEEQ--VSTTERVFQDRQYQIDAAIVRIMKMR CUL4A_HUMAN CUL4A_HUMAN DKFIFNGEFKHKLFRIKINQIQMK--ETVEEQ--VSTTERVFQDRQYQIDAAIVRIMKMR A8MSH7_HUMAN A8MSH7_HUMAN DKFIFNGEFKHKLFRIKINQIQMK--ETVEEQ--VSTTERVFQDRQYQIDAAIVRIMKMR B4DKT2_HUMAN B4DKT2_HUMAN DKFIFNGEFKHKLFRIKINQIQMK--ETVEEQ--VSTTERVFQDRQYQIDAAIVRIMKMR Q4RV94_TETNG Q4RV94_TETNG DIFTVNDEFSSKKYKVKMKLVPGKKEAAVPQKEGEKTRYRVDQERKLQIEAAIVRIMKSK Q6P0Z1_DANRE Q6P0Z1_DANRE HVFTVNDQFTSKLHRVKIQTVAAKQGESDPER--KETRQKVDDDRKHEIEAAIVRIMKSR Q6TEL5_DANRE Q6TEL5_DANRE HVFTVNDQFTSKLHRVKIQTVAAKQGESDPER--KETRQKVDDDRKHEIEAAIVRIMKSR B3DIU1_DANRE B3DIU1_DANRE HVFTVNDQFTSRLHRVKIQTVAAKQGESDPER--KETRQKVDDDRKHEIEAAIVRIMKSR CUL3_MOUSE CUL3_MOUSE HIFTVNDQFTSKLHRVKIQTVAAKQGESDPER--KETRQKVDDDRKHEIEAAIVRIMKSR Q6ZQ84_MOUSE Q6ZQ84_MOUSE HIFTVNDQFTSKLHRVKIQTVAAKQGESDPER--KETRQKVDDDRKHEIEAAIVRIMKSR B5DF89_RAT B5DF89_RAT HIFTVNDQFTSKLHRVKIQTVAAKQGESDPER--KETRQKVDDDRKHEIEAAIVRIMKSR CUL3_HUMAN CUL3_HUMAN HIFTVNDQFTSKLHRVKIQTVAAKQGESDPER--KETRQKVDDDRKHEIEAAIVRIMKSR Q53S54_HUMAN Q53S54_HUMAN HIFTVNDQFTSKLHRVKIQTVAAKQGESDPER--KETRQKVDDDRKHEIEAAIVRIMKSR B8ZZC3_HUMAN B8ZZC3_HUMAN HIFTVNDQFTSKLHRVKIQTVAAKQGESDPER--KETRQKVDDDRKHEIEAAIVRIMKSR Q4R4A5_MACFA Q4R4A5_MACFA HIFTVNDQFTSKLHRVKIQTVAAKQGESDPER--KETRQKVDDDRKHEIEAAIVRIMKSR B7Z600_HUMAN B7Z600_HUMAN HIFTVNDQFTSKLHRVKIQTVAAKQGESDPER--KETRQKVDDDRKHEIEAAIVRIMKSR MATCH CONSENSUS ??F??N??F???L?R?KI?????K??E???E?????T???V??DR???I?AAIVRIMK?R

Q1WF16_FELCA Q1WF16_FELCA KTLSHSVLLSELYNQLK--FTLQPSDLKTRVESLIDRDYMERDKENPNEYKYIA Q7T2C1_DANRE Q7T2C1_DANRE ------------------------------------------------------ Q4SHX5_TETNG Q4SHX5_TETNG KTLSHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKETPNQYHYVA B1H1S6_XENLA B1H1S6_XENLA ------------------------------------------------------ Q08D74_XENTR Q08D74_XENTR KTLTHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKDNAKQYHYLA Q28FG3_XENTR Q28FG3_XENTR KTLTHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKDNAKQYHYLA B5X1T6_SALSA B5X1T6_SALSA ---------------------------------------------------FMA Q8CHD6_MOUSE Q8CHD6_MOUSE KTLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQSNYIA Q9CZM5_MOUSE Q9CZM5_MOUSE KTLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA Q99KS9_MOUSE Q99KS9_MOUSE KTLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA Q8BSL3_MOUSE Q8BSL3_MOUSE KTLSHNLLVSEVYNRLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA A2A432_MOUSE A2A432_MOUSE KTLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA Q3TU30_MOUSE Q3TU30_MOUSE KTLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA B3KVX4_HUMAN B3KVX4_HUMAN KTLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA B7Z5K8_HUMAN B7Z5K8_HUMAN KTLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA CUL4B_HUMAN CUL4B_HUMAN KTLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA Q1WF15_FELCA Q1WF15_FELCA KTLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA B1APK5_HUMAN B1APK5_HUMAN KTLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA Q498E8_XENLA Q498E8_XENLA KTLTHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYVA B2GU90_XENTR B2GU90_XENTR KTLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYVA B3DLE7_XENTR B3DLE7_XENTR KTLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYVA B3DLF2_XENTR B3DLF2_XENTR KTLSRNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYVA Q4RTC1_TETNG Q4RTC1_TETNG KTLSHNLLMSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENSNQYNYVA Q4TI50_TETNG Q4TI50_TETNG ------------------------------------------------------ B3EX44_SORAR B3EX44_SORAR KTLSHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKDSPNQYHYVA B2RYJ3_RAT B2RYJ3_RAT KTLGHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKDSPNQYHYVA Q8R1T2_MOUSE Q8R1T2_MOUSE KTLGHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKDSPNQYHYVA CUL4A_MOUSE CUL4A_MOUSE KTLGHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKDSPNQYHYVA Q3UD60_MOUSE Q3UD60_MOUSE ------------------------------------------------------ B4USY1_OTOGA B4USY1_OTOGA KTLGHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA B2RBV7_HUMAN B2RBV7_HUMAN KTLGHNLLVSELYNQPK--FPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA CUL4A_HUMAN CUL4A_HUMAN KTLGHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA A8MSH7_HUMAN A8MSH7_HUMAN KTLGHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA B4DKT2_HUMAN B4DKT2_HUMAN KTLGHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA Q4RV94_TETNG Q4RV94_TETNG NRLHHRALVTEATDSAA----------AREFPALL----------------CCS Q6P0Z1_DANRE Q6P0Z1_DANRE KKMQHNVLVAEVTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA Q6TEL5_DANRE Q6TEL5_DANRE KKMQHNVLVAEVTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA B3DIU1_DANRE B3DIU1_DANRE KKMQHNVLVAEVTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA CUL3_MOUSE CUL3_MOUSE KKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA Q6ZQ84_MOUSE Q6ZQ84_MOUSE KKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA B5DF89_RAT B5DF89_RAT KKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA CUL3_HUMAN CUL3_HUMAN KKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA Q53S54_HUMAN Q53S54_HUMAN KKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA B8ZZC3_HUMAN B8ZZC3_HUMAN KKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA Q4R4A5_MACFA Q4R4A5_MACFA KKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA B7Z600_HUMAN B7Z600_HUMAN KKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA MATCH CONSENSUS K???HN?LV?E???QLK??F???P???KKRIE?LI?R?Y??R???????Y?Y?A


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