Alignment of the gene Family HBG003674 of HOVERGEN

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Isoforms are ON
Q32PR1_DANRE Q32PR1_DANRE ------MKLRSWPGALHGLALLAFLCHC-ATAVE-----RHYYIAAVNINWDYT------ CERU_SHEEP CERU_SHEEP -------------MKIFLLCIFLILCGTSVWAKD-----KHYYIGIIETAWNYASDHAE- A8K5A4_HUMAN A8K5A4_HUMAN -------------MKILILGIFLFLCSTPAWAKE-----KHYYIGIIETTWDYASDHGE- B3KTA8_HUMAN B3KTA8_HUMAN ------------------------------------------------------------ B7Z5Q2_HUMAN B7Z5Q2_HUMAN -------------MKILILGIFLFLCSTPAWAKE-----KHYYIGIIETTWDYASDHGE- A5PL27_HUMAN A5PL27_HUMAN -------------MKILILGIFLFLCSTPAWAKE-----KHYYIGIIETTWDYASDHGE- CERU_HUMAN CERU_HUMAN -------------MKILILGIFLFLCSTPAWAKE-----KHYYIGIIETTWDYASDHGE- Q1L857_HUMAN Q1L857_HUMAN -------------MKILILGIFLFLCSTPAWAKE-----KHYYIGIIETTWDYASDHGE- CERU_MOUSE CERU_MOUSE -------------MKFLLLSTFIFLYSSLALARD-----KHYFIGITEAVWDYASGTEE- Q8BV37_MOUSE Q8BV37_MOUSE ------------------------------------------------------------ CERU_RAT CERU_RAT -------------MKFLLLSALLFLHSSLAWTRE-----KHYYIGITEAVWDYASGSEE- Q9JL97_RAT Q9JL97_RAT -------------MKFLLLSALLFLHSSLAWTRE-----KHYYIGITEAVWDYASGSEE- Q7ZU12_DANRE Q7ZU12_DANRE ------------MKGLQFALLWVLCCAGIASSIT-----REYFFAIKEIQWDYAPSGKNL Q1MT25_DANRE Q1MT25_DANRE LRTLIAESQWSDMKGLQFALLGVLCCAGIASSIT-----REYFFAIKEIQWDYAPSGKNL Q6P3G1_DANRE Q6P3G1_DANRE ------------MKGLQFALLGVLCCAGIASSIT-----REYFFAIKEIQWDYAPSGKNL Q90ZT2_DANRE Q90ZT2_DANRE ------------------------------------------------------------ A6PYT6_CHIRA A6PYT6_CHIRA ------------MHRLGLRGVLLLCFA--AACVS--GMRREYFLRIEEVSWNYAPTGMNI Q4T8Z9_TETNG Q4T8Z9_TETNG ------------------------------------GTTREYFFRIEEVSWNYAPTGMNV B1AJX8_HUMAN B1AJX8_HUMAN ------------------------------------------------------------ Q5JZ08_HUMAN Q5JZ08_HUMAN ------------MESGHLLWALLFMQS--LWPQLTDGATRVYYLGIRDVQWNYAPKGRNV HEPH_HUMAN HEPH_HUMAN ------------MESGHLLWALLFMQS--LWPQLTDGATRVYYLGIRDVQWNYAPKGRNV Q1HE23_HUMAN Q1HE23_HUMAN ------------MESGHLLWALLFMQS--LWPQLTDGATRVYYLGIRDVQWNYAPKGRNV HEPH_RAT HEPH_RAT ------------MKAGHLLWALLLMHS--LCSLPTDGAIRNYYLGIQDIQWNYAPKGRNV A2AI62_MOUSE A2AI62_MOUSE ------------MKAGHLLWALLLMHS--LWSIPTDGAIRNYYLGIQDMQWNYAPKGRNV A2AI63_MOUSE A2AI63_MOUSE ------------MKAGHLLWALLLMHS--LWSIPTDGAIRNYYLGIQDMQWNYAPKGRNV HEPH_MOUSE HEPH_MOUSE ------------MKAGHLLWALLLMHS--LWSIPTDGAIRNYYLGIQDMQWNYAPKGRNV Q4SFU7_TETNG Q4SFU7_TETNG ------------------------------------------------------------ HPHL1_HUMAN HPHL1_HUMAN -------------MPRKQPAGCIFLLTFLGLSGLVGTVTRTYYIGIVEEYWNYVPQGKNV HPHL1_MOUSE HPHL1_MOUSE --------MFLKQPGGCILLQFLGLLG------LVGAVTRTYYIGIVEEYWNYVPQGKDV MATCH CONSENSUS ?????????????????????????????????????????Y????????W?Y???????

Q32PR1_DANRE Q32PR1_DANRE -----------------SGQQRTGQSYKKVVYREYNEG-FKQPKAHPLSSGLLGPTLRGQ CERU_SHEEP CERU_SHEEP -KKLISVDTEHSNIYLQNGPNRIGSVYKKAVYLQYTDENFRTVIEKPVWLGFLGPIIKAE A8K5A4_HUMAN A8K5A4_HUMAN -KKLISVDTEHSNIYLQNGPDRIGRLYKKALYLQYTDETFRTTIEKPVWLGFLGPIIKAE B3KTA8_HUMAN B3KTA8_HUMAN ------------------------------------------------------------ B7Z5Q2_HUMAN B7Z5Q2_HUMAN -KKLISVDTEHSNIYLQNGPDRIGRLYKKALYLQYTDETFRTTIEKPVWLGFLGPIIKAE A5PL27_HUMAN A5PL27_HUMAN -KKLISVDTEHSNIYLQNGPDRIGRLYKKALYLQYTDETFRTTIEKPVWLGFLGPIIKAE CERU_HUMAN CERU_HUMAN -KKLISVDTEHSNIYLQNGPDRIGRLYKKALYLQYTDETFRTTIEKPVWLGFLGPIIKAE Q1L857_HUMAN Q1L857_HUMAN -KKLISVDTEHSNIYLQNGPDRIGRLYKKALYLQYTDETFRTTIEKPVWLGFLGPIIKAE CERU_MOUSE CERU_MOUSE -KKLISVDTEQSNFYLQNGPDRIGRKYKKALYFEYTDGTFSKTIDKPAWLGFLGPVIKAE Q8BV37_MOUSE Q8BV37_MOUSE ------------------------------------------------------------ CERU_RAT CERU_RAT -KELISVDTEQSNFYLRNGPDRIGRKYKKALYSEYTDGTFTKTIDKPAWLGFLGPVIKAE Q9JL97_RAT Q9JL97_RAT -KELISVDTEQSNFYLRNGPDRIGRKYKKALYSEYTDGTFTKTIDKPAWLGLLGPVIKAE Q7ZU12_DANRE Q7ZU12_DANRE IQNKTVQQDEAARVFLERGEQRIGRVYKKAVYHQYTDATYRQEIDKPKWLGYLGPLISAE Q1MT25_DANRE Q1MT25_DANRE IQNKTVQQDEAARVFLERGEQRIGRVYKKAVYHQYTDATYRQEIDKPKWLGYLGPLISAE Q6P3G1_DANRE Q6P3G1_DANRE IQNKTVQQDEAARVFLERGEQRIGRVYKKAVYHQYTDATYRQEIDKPKWLGYLGPLISAE Q90ZT2_DANRE Q90ZT2_DANRE ---------------------------------------------RP------------- A6PYT6_CHIRA A6PYT6_CHIRA IQNRTLQEDEEASVFLVKGPQRIGSTYKKAVYKQYTDSSYRTEVIKPDWLGYLGPLLMSE Q4T8Z9_TETNG Q4T8Z9_TETNG IQNRTLDEDEEASVFLKKGPQRIGPIYKKAVYKQYSDATYRTEVEKPGWLGYLGPLIVAE B1AJX8_HUMAN B1AJX8_HUMAN ------------------------------------------------------------ Q5JZ08_HUMAN Q5JZ08_HUMAN ITNQPLDSDIVASSFLKSDKNRIGGTYKKTIYKEYKDDSYTDEVAQPAWLGFLGPVLQAE HEPH_HUMAN HEPH_HUMAN ITNQPLDSDIVASSFLKSDKNRIGGTYKKTIYKEYKDDSYTDEVAQPAWLGFLGPVLQAE Q1HE23_HUMAN Q1HE23_HUMAN ITNQPLDSDIVASSFLKSDKNRIGGTYKKTIYKEYKDDSYTDEVAQPAWLGFLGPVLQAE HEPH_RAT HEPH_RAT ITNQTLNNDTVASSFLKSGKNRIGGTYKKTVYKEYSDGTYTNEIAKPAWLGFLGPLLKAE A2AI62_MOUSE A2AI62_MOUSE ITNQTLNNDTVASSFLKSGKNRIGSSYKKTVYKEYSDGTYTEEIAKPAWLGFLGPLLQAE A2AI63_MOUSE A2AI63_MOUSE ITNQTLNNDTVASSFLKSGKNRIGSSYKKTVYKEYSDGTYTEEIAKPAWLGFLGPLLQAE HEPH_MOUSE HEPH_MOUSE ITNQTLNNDTVASSFLKSGKNRIGSSYKKTVYKEYSDGTYTEEIAKPAWLGFLGPLLQAE Q4SFU7_TETNG Q4SFU7_TETNG ------------------------------MFRQFTDRTYSERVLGPAWLGFLGPILRAE HPHL1_HUMAN HPHL1_HUMAN ITGKSFTEDKLATLFLERGPNRIGSIYKKAVYRRFTDGTYSIEIPKPPWLGFLGPILRAE HPHL1_MOUSE HPHL1_MOUSE ITGKSFSEDKLATLFLERGPNRIGGIYKKAVYRHFTDGSYSTEIPKPPWLGFLGPILRAE MATCH CONSENSUS ?????????????????????R?G??YKK??Y????D?????????P?WLG?LGP????E

Q32PR1_DANRE Q32PR1_DANRE EGDTIIVTFRNMADHPCSLHPHGIAYGKQSEGSLYFDNTSLLEKNDDVIQPGEEHTYQWD CERU_SHEEP CERU_SHEEP TGDKVYVHLKNFASRPYTFHAHGLTYYKEHEGAIYPDNTTDLQKADDKVQPGEQCLYILH A8K5A4_HUMAN A8K5A4_HUMAN TGDKVYVHLKNLASRPYTFHSHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLL B3KTA8_HUMAN B3KTA8_HUMAN ------------------------------------------------------------ B7Z5Q2_HUMAN B7Z5Q2_HUMAN TGDKVYVHLKNLASRPYTFHSHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLL A5PL27_HUMAN A5PL27_HUMAN TGDKVYVHLKNLASRPYTFHSHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLL CERU_HUMAN CERU_HUMAN TGDKVYVHLKNLASRPYTFHSHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLL Q1L857_HUMAN Q1L857_HUMAN TGDKVYVHLKNLASRPYTFHSHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLL CERU_MOUSE CERU_MOUSE VEDKVYVHLKNLASRIYTFHAHGVTYTKEYEGAVYPDNTTDFQRADDKVLPGQQYVYVLH Q8BV37_MOUSE Q8BV37_MOUSE ------------------------------------------------------------ CERU_RAT CERU_RAT VGDKVSVHVKNFASRPYTFHAHGVTYTKANEGAIYPDNTTDFQRADDKLFPGQQYLYVLR Q9JL97_RAT Q9JL97_RAT VGDKVSVHVKNFASRPYTFHAHGVTYTKANEGAIYPDNTTDFQRADDKLFPGQQYLYVLR Q7ZU12_DANRE Q7ZU12_DANRE EDDTVIVHLKNMARRAYSLHAHGLSYNKTNEGALYPDSSEKVEKHDDSVAPGTTFTYIWT Q1MT25_DANRE Q1MT25_DANRE EDDTVIVHLKNMARRAYSLHAHGLSYNKTNEGALYPDSSEKVEKHDDSVAPGTTFTYIWT Q6P3G1_DANRE Q6P3G1_DANRE EDDTVIVHLKNMARRAYSLHAHGLSYNKTNEGALYPDSSEKVEKHDDSVAPGTTFTYIWT Q90ZT2_DANRE Q90ZT2_DANRE ------VTFRNKASRPFSIQPHGVQYNIDMDGTLYHN----------------------- A6PYT6_CHIRA A6PYT6_CHIRA EGDTVIVPLKNIATRPYSIHPHGLNYSKGNEGALYPDGTGPELKRDDSVAPGSIVTYEWT Q4T8Z9_TETNG Q4T8Z9_TETNG EGDTVIIHLRNIASRPYSIHPHGQNYSKSSEGALYPDNTGPEEKRDDSVLPGTTVIYDWT B1AJX8_HUMAN B1AJX8_HUMAN ------------------------------------------------------------ Q5JZ08_HUMAN Q5JZ08_HUMAN VGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLYPDGSSGPLKADDSVPPGGSHIYNWT HEPH_HUMAN HEPH_HUMAN VGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLYPDGSSGPLKADDSVPPGGSHIYNWT Q1HE23_HUMAN Q1HE23_HUMAN VGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLYPDGSSGPLKADDSVPPGGSHIYNWT HEPH_RAT HEPH_RAT MGDVILIHLKNFASRPYTIHPHGVFYEKDSEGSLYPDGSSGYLKADDSVPPGGSHVYNWS A2AI62_MOUSE A2AI62_MOUSE VGDVILIHLKNFASRPYTIHPHGVFYEKDSEGSLYPDGSSGYLKADDSVPPGGSHVYNWS A2AI63_MOUSE A2AI63_MOUSE VGDVILIHLKNFASRPYTIHPHGVFYEKDSEGSLYPDGSSGYLKADDSVPPGGSHVYNWS HEPH_MOUSE HEPH_MOUSE VGDVILIHLKNFASRPYTIHPHGVFYEKDSEGSLYPDGSSGYLKADDSVPPGGSHVYNWS Q4SFU7_TETNG Q4SFU7_TETNG VDDVIIVHLKNFASRNYSIHPHGVFYKKEAEGALYPDGTSKDKKMDDSVPPGGSYTYRWE HPHL1_HUMAN HPHL1_HUMAN VGDVIVIHLKNFASRPYSLHPHGVFYNKDSEGALYPDGTSGRNKNDDMVPPGKNYTYVWP HPHL1_MOUSE HPHL1_MOUSE VGDVIVIHLMNFASRPFSLHPHGVFYDKDSEGALYPDGTSGRNKEDDMVPPGKNYTYVWP MATCH CONSENSUS ??D???????N?A?R????H?HG??Y?K??EG??YPD????????DD???PG????Y???

Q32PR1_DANRE Q32PR1_DANRE VTSDVTPTAADPPCITYTYLSHFDIVRDYNTGLIGPMLICKKGTLDD--SG--NQIHFHQ CERU_SHEEP CERU_SHEEP ANPEQGPGEEDSNCVTRIYHSHIDAPKDIASGLIGPLIHCKKDSLDE--E---KEKNIDK A8K5A4_HUMAN A8K5A4_HUMAN ATEEQSPGEGDGNCVTRIYHSHIDAPKDIASGLIGPLIICKKDSLDK--E---KEKHIDR B3KTA8_HUMAN B3KTA8_HUMAN ------------------------------------------------------------ B7Z5Q2_HUMAN B7Z5Q2_HUMAN ATEEQSPGEGDGNCVTRIYHSHIDAPKDIASGLIGPLIICKKDSLDK--E---KEKHIDR A5PL27_HUMAN A5PL27_HUMAN ATEEQSPGEGDGNCVTRIYHSHIDAPKDIASGLIGPLIICKKDSLDK--E---KEKHIDR CERU_HUMAN CERU_HUMAN ATEEQSPGEGDGNCVTRIYHSHIDAPKDIASGLIGPLIICKKDSLDK--E---KEKHIDR Q1L857_HUMAN Q1L857_HUMAN ATEEQSPGEGDGNCVTRIYHSHIDAPKDIASGLIGPLIICKKDSLDK--E---KEKHIDR CERU_MOUSE CERU_MOUSE ANE-PSPGEGDSNCVTRIYHSHVDAPKDIASGLIGPLILCKKGSLYK--E---KEKNIDQ Q8BV37_MOUSE Q8BV37_MOUSE ------------------------------------------------------------ CERU_RAT CERU_RAT ANE-PSPGEGDSNCVTRIYHSHVDAPKDIASGLIGPLILCKKGSLHK--E---KEENIDQ Q9JL97_RAT Q9JL97_RAT ANE-PSPGEGDSNCVTRIYHSHVDAPKDIASGLIGPLILCKKGSLHK--E---KEENIDQ Q7ZU12_DANRE Q7ZU12_DANRE LPASHAPGKDDTNCLTRIYHSHVNAPKDIASGLIGPLIVCKKGSLDV-----HGDKTGDY Q1MT25_DANRE Q1MT25_DANRE LPASHAPGKDDTNCLTRIYHSHVNAPKDIASGLIGPLIVCKKGSLDV-----HGDKTGDY Q6P3G1_DANRE Q6P3G1_DANRE LPASHAPGKDDTNCLTRIYHSHVNAPKDIASGLIGPLIVCKKGSLDV--H---GDKTGDY Q90ZT2_DANRE Q90ZT2_DANRE ------------------------------------------------------------ A6PYT6_CHIRA A6PYT6_CHIRA LPETHSPTPEDSNCLTKFYHSHVSPPKDISAGLIGPLIVCKRGTLDL--H---GDSSSDY Q4T8Z9_TETNG Q4T8Z9_TETNG LPESHAPTLKDSNCLTRFYHSHVNTPKDINSGLIGPLIICKKGTLDL--H---GDRTGDY B1AJX8_HUMAN B1AJX8_HUMAN ------------------------------------------------------------ Q5JZ08_HUMAN Q5JZ08_HUMAN IPEGHAPTDADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGALDG--NSPPQRQDVDH HEPH_HUMAN HEPH_HUMAN IPEGHAPTDADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGALDG--NSPPQRQDVDH Q1HE23_HUMAN Q1HE23_HUMAN IPEGHAPTDADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGALDG--NSPPQRQDVDH HEPH_RAT HEPH_RAT IPEGHAPTEADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGTLDG--NSPPQRKDVDH A2AI62_MOUSE A2AI62_MOUSE IPESHAPTEADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGTLDG--NSPPQRKDVDH A2AI63_MOUSE A2AI63_MOUSE IPESHAPTEADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGTLDG--NSPPQRKDVDH HEPH_MOUSE HEPH_MOUSE IPESHAPTEADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGTLDG--NSPPQRKDVDH Q4SFU7_TETNG Q4SFU7_TETNG VRPEFAPTDDDANCLTWVYHSHVDAPRDVASGLIGSLLTCKKGVLKEAADSAQVRNDVVQ HPHL1_HUMAN HPHL1_HUMAN VREEYAPTPADANCLTWVYHSHIDAPKDICSGLIGPLLVCKEGILNR--YSG-TRNDVDR HPHL1_MOUSE HPHL1_MOUSE VREEYAPAPADANCLTWVYHSHIDAPKDICSGLIGPLLVCKEGVLNRYSG---MRTDVDR MATCH CONSENSUS ??????P???D??C?T??YHSH???P?D???GLIGPL??CK???L???????????????

Q32PR1_DANRE Q32PR1_DANRE ESVLLFGVFDENKSWY----------------STGDSPRPLNVKYTINGYTNGSVPDLDI CERU_SHEEP CERU_SHEEP EFVVMFSVVDENLSWYLEENIKTYCSEPEKVEQDNEDFQESNRMYSVNGYAFGSLPGLSM A8K5A4_HUMAN A8K5A4_HUMAN EFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDFQESNRMYSVNGYTFGSLPGLSM B3KTA8_HUMAN B3KTA8_HUMAN ------------------------------------------------------------ B7Z5Q2_HUMAN B7Z5Q2_HUMAN EFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDFQESNRMYSVNGYTFGSLLGLSM A5PL27_HUMAN A5PL27_HUMAN EFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDFQESNRMYSVNGYTFGSLPGLSM CERU_HUMAN CERU_HUMAN EFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDFQESNRMYSVNGYTFGSLPGLSM Q1L857_HUMAN Q1L857_HUMAN EFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDFQESNRMYSVNGYTFGSLPGLSM CERU_MOUSE CERU_MOUSE EFVLMFSVVDENLSWYLEDNIKTFCSEPEKVDKDNEDFQESNRMYSINGYTFGSLPGLSM Q8BV37_MOUSE Q8BV37_MOUSE ------------------------------------------------------------ CERU_RAT CERU_RAT EFVLMFSVVDENLSWYLEDNIKTFCSEPEKVDKDNEDFQESNRMYSINGYTFGSLPGLSM Q9JL97_RAT Q9JL97_RAT EFVLMFSVVDENLSWYLEDNIKTFCSEPEKVDKDNEDFQESNRMYSINGYTFGSLPGLSM Q7ZU12_DANRE Q7ZU12_DANRE LYTLMFTVSDENLSWYLDENIKTYCSAPAKVNKDDEAFQESNKMHSINGYVYGNLPDLSM Q1MT25_DANRE Q1MT25_DANRE LYTLMFTVSDENLSWYLDENIKTYCSAPAKVNKDDEAFQESNKMHSINGYVYGNLPDLSM Q6P3G1_DANRE Q6P3G1_DANRE LYTLMFTVSDENLSWYLDENIKTYCSAPAKVNKDDEAFQESNKMHSINGYVYGNLPDLSM Q90ZT2_DANRE Q90ZT2_DANRE ------------------------------------------------------------ A6PYT6_CHIRA A6PYT6_CHIRA LYALLFMVADENFSWYLDENIRTHITSPAKDLKNDEDFIESNKMHGINGFLYGNLPGLTM Q4T8Z9_TETNG Q4T8Z9_TETNG QYALLFMVSDENFSWYLDDNIKTYVTNPARDLKDDEDFIESNKMHGINGLLYGNLPGLSI B1AJX8_HUMAN B1AJX8_HUMAN -------------------------------------------MHAINGFVFGNLPELNM Q5JZ08_HUMAN Q5JZ08_HUMAN DFFLLFSVVDENLSWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGNLPELNM HEPH_HUMAN HEPH_HUMAN DFFLLFSVVDENLSWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGNLPELNM Q1HE23_HUMAN Q1HE23_HUMAN DFFLLFSVVDENLSWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGNLPELNM HEPH_RAT HEPH_RAT NFFLLFSVIDENLSWHLDDNIATYCSDPASVDKEDGPFQDSNRMHAINGFVFGNLPELSM A2AI62_MOUSE A2AI62_MOUSE NFFLLFSVIDENLSWHLDDNIATYCSDPASVDKEDGAFQDSNRMHAINGFVFGNLPELSM A2AI63_MOUSE A2AI63_MOUSE NFFLLFSVIDENLSWHLDDNIATYCSDPASVDKEDGAFQDSNRMHAINGFVFGNLPELSM HEPH_MOUSE HEPH_MOUSE NFFLLFSVIDENLSWHLDDNIATYCSDPASVDKEDGAFQDSNRMHAINGFVFGNLPELSM Q4SFU7_TETNG Q4SFU7_TETNG EVVLMFNVVDENLSWYQEENIQS-CYNPKEVDLDDPDFHDSNLMHAINGYTFGTLPGISL HPHL1_HUMAN HPHL1_HUMAN EFVIMFTLVDENQSWYLNENIKHFCTNPDSVDKKDAVFQRSNKMHALNGYLFGNFPEPDM HPHL1_MOUSE HPHL1_MOUSE EFVIMFTLVDENQSWYLDDNIKQFCTNPNSVDKSDAVFQRSNKMHALNGFLFGNMPEPEM MATCH CONSENSUS ?????F???DEN?SW????NI??????P?????????F??SN?M???NG???G??P????

Q32PR1_DANRE Q32PR1_DANRE CAHSKVSWHLLGMSSEPELFSVHFNGQVLLHDGHKTSAVGIISGTATSASMTGVHPGRWL CERU_SHEEP CERU_SHEEP CAEDRVKWYLFGMGNEIDVHAAFFHGQVLTSKNYRVDTINLFPATLFDAFMVAQNPGQWM A8K5A4_HUMAN A8K5A4_HUMAN CAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINLFPATLFDAYMVAQSPGEWM B3KTA8_HUMAN B3KTA8_HUMAN ------------MGNEVDVHAAFFHGQALTNKNYRIDTINLFPATLFDAYMVAQNPGEWM B7Z5Q2_HUMAN B7Z5Q2_HUMAN CAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINLFPATLFDAYMVAQNPGEWM A5PL27_HUMAN A5PL27_HUMAN CAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINLFPATLFDAYMVAQNPGEWM CERU_HUMAN CERU_HUMAN CAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINLFPATLFDAYMVAQNPGEWM Q1L857_HUMAN Q1L857_HUMAN CAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINLFPATLFDAYMVAQNPGEWM CERU_MOUSE CERU_MOUSE CAADRVKWYLFGMGNEVDVHSAFFHGQALTSRNYQTDIINLFPATLIDAYMVAQNPGVWM Q8BV37_MOUSE Q8BV37_MOUSE ------------------------------------------------------------ CERU_RAT CERU_RAT CAEDRVKWYLFGMGNEVDVHSELFHGQALTSKNYHTDIINLFPATLIDVSMVAQNPGVWM Q9JL97_RAT Q9JL97_RAT CAEDRVKWYLFGMGNEVDVHSELFHGQALTSKNYHTDIINLFPATLIDVSMVAQNPGVWM Q7ZU12_DANRE Q7ZU12_DANRE CMGNKIHWHLFGMGNEVDIHSAFFHGQILTDKRQHVDTVSLFPATFVNVEMVADNPGQWL Q1MT25_DANRE Q1MT25_DANRE CIGNKIHWHLFGMGNEVDIHSAFFHGQILTDKRQHVDTVSLFPATFVNVEMVADNPGQWL Q6P3G1_DANRE Q6P3G1_DANRE CIGNKIHWHLFGMGNEVDIHSAFFHGQILTDKRQHVDTVSLFPATFVNVEMVADNPGQWL Q90ZT2_DANRE Q90ZT2_DANRE ------------------------------------------------------------ A6PYT6_CHIRA A6PYT6_CHIRA CQGNKIHWHLIGLGNEVDMHSIHFHGQILTVQNHHTDTVSLFPASSTTAEMVADNPGHWL Q4T8Z9_TETNG Q4T8Z9_TETNG CQGNKIHWHLFGLGNEVDIHSVHFHGQILTALNRHTDTVSLSPGSSTTAEMMADNVGHWL B1AJX8_HUMAN B1AJX8_HUMAN CAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWL Q5JZ08_HUMAN Q5JZ08_HUMAN CAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWL HEPH_HUMAN HEPH_HUMAN CAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWL Q1HE23_HUMAN Q1HE23_HUMAN CAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWL HEPH_RAT HEPH_RAT CAQKHVAWHLFGMGNEIDVHTAFFHGQTLSIRGHRTDVAHIFPATFVTAEMVPQKSGTWL A2AI62_MOUSE A2AI62_MOUSE CAQKHVAWHLFGMGNEIDVHTAFFHGQMLSIRGHHTDVANIFPATFVTAEMVPQKSGTWL A2AI63_MOUSE A2AI63_MOUSE CAQKHVAWHLFGMGNEIDVHTAFFHGQMLSIRGHHTDVANIFPATFVTAEMVPQKSGTWL HEPH_MOUSE HEPH_MOUSE CAQKHVAWHLFGMGNEIDVHTAFFHGQMLSIRGHHTDVANIFPATFVTAEMVPQKSGTWL Q4SFU7_TETNG Q4SFU7_TETNG CQGQAVAWHLFGMGNEMDVHSAFFHGNTVLDRGHRTDVLSLFPATFATAEMVPQARGKWL HPHL1_HUMAN HPHL1_HUMAN CVGESVSWHLFGMGNEIDIHSIYFYGNTFISRGHRTDVVNLFPATFLTTEMIAENPGKWM HPHL1_MOUSE HPHL1_MOUSE CVGESVSWHLFGMGNEIDIHSIYFYGNTFITRGHRADVVNLFPATFLTTEMIVENPGKWM MATCH CONSENSUS C??????W?LFGMGNE?D?H???FHGQ?L???????D????FPAT?????M?????G?W?

Q32PR1_DANRE Q32PR1_DANRE VSSHISKHLEAGLHGYLNIRKCDEYTAPKRRLTIEQKKESQEWTYYMAAEEVIWDYAPNM CERU_SHEEP CERU_SHEEP LSCQNLNHLKAGLQAFFWVQDCKK-SSSEDNIHGKNVRH-----YYIAAEEVIWNYAPSG A8K5A4_HUMAN A8K5A4_HUMAN LSCQNLNHLKAGLQAFFQVQECNK-SSSKDNIRGKHVRH-----YYIAAEEIIWNYAPSG B3KTA8_HUMAN B3KTA8_HUMAN LSCQNLNHLKAGLQAFFQVQECNK-SSSKDNIRGKHVRH-----YYIAAEEIIWNYAPSG B7Z5Q2_HUMAN B7Z5Q2_HUMAN LSCQNLNHLKAGLQAFFQVQECNK-SSSKDNIRGKHVRH-----YYIAAEEIIWNYAPSG A5PL27_HUMAN A5PL27_HUMAN LSCQNLNHLKAGLQAFFQVQECNK-SSSKDNIRGKHVRH-----YYIAAEEIIWNYAPSG CERU_HUMAN CERU_HUMAN LSCQNLNHLKAGLQAFFQVQECNK-SSSKDNIRGKHVRH-----YYIAAEEIIWNYAPSG Q1L857_HUMAN Q1L857_HUMAN LSCQNLNHLKAGLQAFFQVQECNK-SSSKDNIRGKHVRH-----YYIAAEEIIWNYAPSG CERU_MOUSE CERU_MOUSE LSCQNLNHLKAGLQAFFQVRDCNK-PSPEDNIQDRHVRH-----YYIAAEEVIWNYAPSG Q8BV37_MOUSE Q8BV37_MOUSE ------------------------------------------------------------ CERU_RAT CERU_RAT LSCQNLNHLKAGLQAFFQVRDCNK-PSPDDDIQDRHVRH-----YYIAAEETIWDYAPSG Q9JL97_RAT Q9JL97_RAT LSCQNLNHLKAGLQAFFQVRDCNK-PSPDDDIQDRHVRH-----YYIAAEETIWDYAPSG Q7ZU12_DANRE Q7ZU12_DANRE LSCQVNDHLEAGMQAFFEIKKCFP-NVHKPRPFGE-VRQ-----YYIAAEEIIWDYGPTE Q1MT25_DANRE Q1MT25_DANRE LSCQVNDHLEAGMQAFFEIKKCFP-NVHKPRPFGE-VRQ-----YYIAAEEIIWDYGPTE Q6P3G1_DANRE Q6P3G1_DANRE LSCQVNDHLEAGMQAFFEIKKCFP-NVHKPRPFGE-VRQ-----YYIAAEEIIWDYGPTE Q90ZT2_DANRE Q90ZT2_DANRE ------------------------------------------------------------ A6PYT6_CHIRA A6PYT6_CHIRA LACGINDHLTAGMQAIFEIKKCFP-NVHKPQPHGE-LRP-----FFIAAEEDIWDYAP-- Q4T8Z9_TETNG Q4T8Z9_TETNG LTCTVNDHLMAGMQAIFEIKKCFP-NVHKPRPHGE-LRQ-----FFVAAEEEVWDYAP-- B1AJX8_HUMAN B1AJX8_HUMAN ISCQVNSHFRDGMQALYKVKSCSM-APPVDLLTGK-VRQ-----YFIEAHEIQWDYGPMG Q5JZ08_HUMAN Q5JZ08_HUMAN ISCQVNSHFRDGMQALYKVKSCSM-APPVDLLTGK-VRQ-----YFIEAHEIQWDYGPMG HEPH_HUMAN HEPH_HUMAN ISCQVNSHFRDGMQALYKVKSCSM-APPVDLLTGK-VRQ-----YFIEAHEIQWDYGPMG Q1HE23_HUMAN Q1HE23_HUMAN ISCQVNSHFRDGMQALYKVKSCSM-APPVDLLTGK-VRQ-----YFIEAHEIQWDYGPMG HEPH_RAT HEPH_RAT ISCVVNSHLKSGMQAFYKVDSCSM-DPPVEQLTGK-VRQ-----YFIQAHEIQWDYGPIG A2AI62_MOUSE A2AI62_MOUSE ISCEVNSHLRSGMQAFYKVDSCSM-DPPVDQLTGK-VRQ-----YFIQAHEIQWDYGPIG A2AI63_MOUSE A2AI63_MOUSE ISCEVNSHLRSGMQAFYKVDSCSM-DPPVDQLTGK-VRQ-----YFIQAHEIQWDYGPIG HEPH_MOUSE HEPH_MOUSE ISCEVNSHLRSGMQAFYKVDSCSM-DPPVDQLTGK-VRQ-----YFIQAHEIQWDYGPIG Q4SFU7_TETNG Q4SFU7_TETNG LTCQNRDHLKAGEQAFYEVKSCNS-DSSTTQSSPV-VRN-----YYIAVEKVLWDYAPSG HPHL1_HUMAN HPHL1_HUMAN ITCQVSDHLQAGMLGQYNVDNCKS-DIFYPKMKGQ-QRR-----YFIAAEKILWDYAPQG HPHL1_MOUSE HPHL1_MOUSE ITCQVSDHLQAGMLGQYSVGNCRG-NAPHPKVQGQ-QRR-----YFIAAEKVLWDYGPQG MATCH CONSENSUS ??C????H???G?QA??????C???????????????R??????Y?I?A?E??W?Y?P??

Q32PR1_DANRE Q32PR1_DANRE PENMDGDF----------RSKYLKQGPQRIGKKYKKAVFTQYKDGTFKERAEDKQRKREL CERU_SHEEP CERU_SHEEP IDAFTKEN---LRAPGSASEAFFEQGPTRIGGSYKKLVYREYTDASFSNQKERGPEEEHL A8K5A4_HUMAN A8K5A4_HUMAN IDIFTKEN---LTAPGSDSAVFFEQGTTRIGGSYKKLVHREYTDASFTNRKERGPEEEHL B3KTA8_HUMAN B3KTA8_HUMAN IDIFTKEN---LTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDASFTNRKERGPEEEHL B7Z5Q2_HUMAN B7Z5Q2_HUMAN IDIFTKEN---LTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDASFTNRKERGPEEEHL A5PL27_HUMAN A5PL27_HUMAN IDIFTKEN---LTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDASFTNRKERGPEEEHL CERU_HUMAN CERU_HUMAN IDIFTKEN---LTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDASFTNRKERGPEEEHL Q1L857_HUMAN Q1L857_HUMAN IDIFTKEN---LTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDASFTNRKERGPEEEHL CERU_MOUSE CERU_MOUSE TDIFTGEN---LTALESDSRVFFEQGATRIGGSYKKMAYREYTDGSFTNRKQRGPDEEHL Q8BV37_MOUSE Q8BV37_MOUSE ------------------------------------------------------------ CERU_RAT CERU_RAT TDTFTGEN---FTSLGSDSRVFFEQGATRIGGSYKKLVYREYTDDSFTNRKERGPDEEHL Q9JL97_RAT Q9JL97_RAT TDTFTGEN---LTSLGSDSRVFFEQGATRIGGSYKKLVYREYTDDSFTNRKQRGPDEEHL Q7ZU12_DANRE Q7ZU12_DANRE INQYTMKK---LVD-DIVSDTFFDNRNDRIGGKYKKVQYVEYTDDTFTKRKEKTPEEQHL Q1MT25_DANRE Q1MT25_DANRE INQYTMKK---LVD-DIVSDTFFDNRNDRIGGKYKKVQYVEYTDDTFTKRKEKTPEEQHL Q6P3G1_DANRE Q6P3G1_DANRE INQYTMKK---LVD-DIVSDTFFDNRNDRIGGKYKKVQYVEYTDDTFTKRKEKTPEEQHL Q90ZT2_DANRE Q90ZT2_DANRE ------------------------------------VLEESYTDKKLRELKKQ------- A6PYT6_CHIRA A6PYT6_CHIRA -----------IPPTDGDAEQFVTRGRNRIGSRYKKVRYVEYTDNTFTTKMLRSPEEQHL Q4T8Z9_TETNG Q4T8Z9_TETNG -----------TPSGDGEAEVFLTRGGNRIGSRYKKVRYVEYTDNTFMTKMLRSPEELHL B1AJX8_HUMAN B1AJX8_HUMAN HDGSTGKN---LREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHL-EEDRHL Q5JZ08_HUMAN Q5JZ08_HUMAN HDGSTGKN---LREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHL-EEDRHL HEPH_HUMAN HEPH_HUMAN HDGSTGKN---LREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHL-EEDRHL Q1HE23_HUMAN Q1HE23_HUMAN HDGSTGKN---LREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHL-EEDRHL HEPH_RAT HEPH_RAT HDGRTGKS---LREPGSGPDKYFQKSSSRIGGTYWKVRYEAFQDETFQERLHQ-EEETHL A2AI62_MOUSE A2AI62_MOUSE YDGRTGKS---LREPGSGPDKYFQKSSSRIGGTYWKVRYEAFQDETFQERVHQ-EEETHL A2AI63_MOUSE A2AI63_MOUSE YDGRTGKS---LREPGSGPDKYFQKSSSRIGGTYWKVRYEAFQDETFQERVHQ-EEETHL HEPH_MOUSE HEPH_MOUSE YDGRTGKS---LREPGSGPDKYFQKSSSRIGGTYWKVRYEAFQDETFQERVHQ-EEETHL Q4SFU7_TETNG Q4SFU7_TETNG KDLTNHTNHTLLTAEGSASETFFGRNNKRIGGQYNKVMYKEYTDDSFTTEKPQTKEAEHL HPHL1_HUMAN HPHL1_HUMAN YNKFSGLP---LNASGSDSDLYFTQGDNRIGGKYWKVRYTEFVDATFTKRKRLSAEEAHL HPHL1_MOUSE HPHL1_MOUSE YDKFTGFP---LNTSGSDSAVYFTQADNRIGGKYWKARYTEYVDATFSRRKMPSDSEAHL MATCH CONSENSUS ??????????????????????F?????RIGG?Y?K??Y????D??F???????????HL

Q32PR1_DANRE Q32PR1_DANRE GILGPVIRAQIRDIIKIVFKNKASRPYSIYPHGLTIDKAAEGASYPQGGN---------- CERU_SHEEP CERU_SHEEP GILGPVIAAEVGDTIRVTFHNKAAHPLSIEPIGVRVDKNNEGTYYSPTGSG--------- A8K5A4_HUMAN A8K5A4_HUMAN GILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPNYNPQSRS----- B3KTA8_HUMAN B3KTA8_HUMAN GILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPNYNPQSRS----- B7Z5Q2_HUMAN B7Z5Q2_HUMAN GILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPNYNPQSRS----- A5PL27_HUMAN A5PL27_HUMAN GILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPNYNPQSRS----- CERU_HUMAN CERU_HUMAN GILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPNYNPQSRS----- Q1L857_HUMAN Q1L857_HUMAN GILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPNYNPQSRS----- CERU_MOUSE CERU_MOUSE GILGPVIWAEVGDTIKVTFHNKGQHPLSIQPMGVSFTAENEGTYYGPPGRS--------- Q8BV37_MOUSE Q8BV37_MOUSE ------------------------------------------------------------ CERU_RAT CERU_RAT GILGPVIWAEVGDIIRVTFHNKGQFPLSIQPMGVRFTKENEGTYYGPDGR---------- Q9JL97_RAT Q9JL97_RAT GILGPVIWAEVGDIIRVTFHNKGQFPLSIQPMGVRFTKENEGTYYGPDGR---------- Q7ZU12_DANRE Q7ZU12_DANRE GILGPVIRAEEEDTIKVTFRNKASRPFSIQPHGVQYNIDMDGTLYHNVLEESYTDKKLRE Q1MT25_DANRE Q1MT25_DANRE GILGPVIRAEEEDTIKVTFRNKASRPFSIQPHGVQYNIDMDGTLYHNVLEESYTDKKLRE Q6P3G1_DANRE Q6P3G1_DANRE GILGPVIRAEEEDTIKVTFRNKASRPFSIQPHGVQYNIDMDGTLYHNVLEESYTDKKLRE Q90ZT2_DANRE Q90ZT2_DANRE -------------------------PRVIEPL---------------------------- A6PYT6_CHIRA A6PYT6_CHIRA GIMGPVLRAEEKDTIKVVFKNKASRPYSIQPHGVQYSIEDSGTLYYNELEEPHTAKKLRE Q4T8Z9_TETNG Q4T8Z9_TETNG GILGPVLRAEEKDRISVVFKNKASRPYSIQPHGVQYSVEQDGTLYYNELEESYTEKKLRE B1AJX8_HUMAN B1AJX8_HUMAN GILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDG------------ Q5JZ08_HUMAN Q5JZ08_HUMAN GILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYND------------- HEPH_HUMAN HEPH_HUMAN GILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDG------------ Q1HE23_HUMAN Q1HE23_HUMAN GILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDG------------ HEPH_RAT HEPH_RAT GILGPVIRAEVGDTIQVVFYNRASQPFSIQPHGVFYEKSSEGTVYNDG------------ A2AI62_MOUSE A2AI62_MOUSE GILGPVIRAEVGDTIQVVFYNRASQPFSIQPHGVFYEKNSEGTVYND------------- A2AI63_MOUSE A2AI63_MOUSE GILGPVIRAEVGDTIQVVFYNRASQPFSIQPHGVFYEKNSEGTVYNDG------------ HEPH_MOUSE HEPH_MOUSE GILGPVIRAEVGDTIQVVFYNRASQPFSIQPHGVFYEKNSEGTVYNDG------------ Q4SFU7_TETNG Q4SFU7_TETNG GLLGPVLRAEEGDTIKVTLRNKADRAFGIQPHGLFYESCTSSS----------------- HPHL1_HUMAN HPHL1_HUMAN GILGPVIKAEVGDTLLVTFANKADKVYSILPHGVIYDKASDAAPNLDG------------ HPHL1_MOUSE HPHL1_MOUSE GILGPVIKAEVGDILLVTFANKADKVYSILPHGVFYDKASDAAPNVDG------------ MATCH CONSENSUS GILGPVI?AE??D?I?V?F?N????P?SI?P?GV???????G??Y???????????????

Q32PR1_DANRE Q32PR1_DANRE -----------QTYSVQPGETYTYTWSVTEEDVPTDSDPRCLTRMYHSAVDAPRDIASGL CERU_SHEEP CERU_SHEEP --------PPPSGSHVAPKGTFTYEWTVPKEVGPTYKDPVCLAKMYYSG--STKDIFTGL A8K5A4_HUMAN A8K5A4_HUMAN --------VPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTKDIFTGL B3KTA8_HUMAN B3KTA8_HUMAN --------VPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTKDIFTGL B7Z5Q2_HUMAN B7Z5Q2_HUMAN --------VPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTKDIFTGL A5PL27_HUMAN A5PL27_HUMAN --------VPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTKDIFTGL CERU_HUMAN CERU_HUMAN --------VPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTKDIFTGL Q1L857_HUMAN Q1L857_HUMAN --------VPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTKDIFTGL CERU_MOUSE CERU_MOUSE --------SQQAASHVAPKETFTYEWTVPKEMGPTYADPVCLSKMYYSGVDPTKDIFTGL Q8BV37_MOUSE Q8BV37_MOUSE ------------------------------------------------------------ CERU_RAT CERU_RAT --------SSKQASHVAPKETFTYEWTVPKEMGPTYADPVCLSKMYYSGVDLTKDIFTGL Q9JL97_RAT Q9JL97_RAT --------SSKQASHVAPKETFTYEWTVPKEMGPTYADPVCLSKMYYSGVDLTKDIFTGL Q7ZU12_DANRE Q7ZU12_DANRE LKKQPRVIEPLPAAMVRPDTTYKYEWVVPKDGGPTEKDPDCLTYLYYSAVDPIRDTNSGL Q1MT25_DANRE Q1MT25_DANRE LKKQPRVIEPLPAAMVRPDTTYKYEWVVPKDGGPTEKDPDCLTYLYYSAVDPIRDTNSGL Q6P3G1_DANRE Q6P3G1_DANRE LKKQPRVIEPLPAAMVRPDTTYKYEWVVPKDGGPTEKDPDCLTYLYYSAVDPIRDTNSGL Q90ZT2_DANRE Q90ZT2_DANRE -----------PAAMVRPDTTYKYEWVVPKDGGPTEKDPDCLTYLYYSAVDPIRDSNSGL A6PYT6_CHIRA A6PYT6_CHIRA LKKEPRVVTPLPAALVRPGTIYTYEWTVPVDAGPVQGEADCLTYLYYSGVDPVKDTHSGL Q4T8Z9_TETNG Q4T8Z9_TETNG LKKQPRVVTPPPAALVRPGSTHTYEWTVPVGGGPLQGEADCLTYLYYSGVDPVKDTNSGL B1AJX8_HUMAN B1AJX8_HUMAN --------SSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGL Q5JZ08_HUMAN Q5JZ08_HUMAN --------------------------------------------------DPIRDTNSGL HEPH_HUMAN HEPH_HUMAN --------SSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGL Q1HE23_HUMAN Q1HE23_HUMAN --------SSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGL HEPH_RAT HEPH_RAT --------TSYPK-VAKSFEKVTYYWTVPPHAGPTAEDPACLTWMYFSAADPTRDTNSGL A2AI62_MOUSE A2AI62_MOUSE --------------------------------------------------DPTRDTNSGL A2AI63_MOUSE A2AI63_MOUSE --------TSHPK-VAKSFEKVTYYWTVPPHAGPTAQDPACLTWMYFSAADPTRDTNSGL HEPH_MOUSE HEPH_MOUSE --------TSHPK-VAKSFEKVTYYWTVPPHAGPTAQDPACLTWMYFSAADPTRDTNSGL Q4SFU7_TETNG Q4SFU7_TETNG --------KLFTTTYISPGKNFTYVWQV--KDGPSSSDPPCIPYLYFSGAQPVADTYSGL HPHL1_HUMAN HPHL1_HUMAN --------FVKPGAHVKPGETFTYKWTVPESVSPTAGDPPCLTYLYFSAVDPIKDTSSGL HPHL1_MOUSE HPHL1_MOUSE --------FLKPGAHVKPGETFTYRWTVPESVSPTDEDPPCLTYLYFSAVQPIKDTSAGL MATCH CONSENSUS ???????????????????????Y?W?VP????P???DP?CL???Y?S??DP??D???GL

Q32PR1_DANRE Q32PR1_DANRE VGPLLICKSQSLNKKNVQLKADKEQHAMFTVFDENKSWYQDENINTYCSDPKKVKKDDPE CERU_SHEEP CERU_SHEEP IGPMKICRNGSLLANGRLKNVDKEFYLFPTVFDENESLLLDDNIKMFTTAPDQVDKENED A8K5A4_HUMAN A8K5A4_HUMAN IGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDED B3KTA8_HUMAN B3KTA8_HUMAN IGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDED B7Z5Q2_HUMAN B7Z5Q2_HUMAN IGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDED A5PL27_HUMAN A5PL27_HUMAN IGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDED CERU_HUMAN CERU_HUMAN IGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDED Q1L857_HUMAN Q1L857_HUMAN IGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDED CERU_MOUSE CERU_MOUSE IGPMKICKKGSLLADGRQKDVDKEFYLFPTVFDENESLLLDDNIRMFTTAPDQVDKEDED Q8BV37_MOUSE Q8BV37_MOUSE ----------SLLADGRQKDVDKEFYLFPTVFDENESLLLDDNIRMFTTAPDQVDKEDED CERU_RAT CERU_RAT IGPMKICKKGSLLADGRQKDVDKEFYLFATVFDENESLLLDDNIRMFTTAPENVDKEDED Q9JL97_RAT Q9JL97_RAT IGPMKICKKGSLLADGRQKDVDKEFYLFATVFDENESLLLDDNIRMFTTAPENVDKEDED Q7ZU12_DANRE Q7ZU12_DANRE VGPLLICKPKTL-KSGKQKNVDKEFHLLATVFDENLSWYLDDNINRYAKQPKSVNKEDAD Q1MT25_DANRE Q1MT25_DANRE VGPLLICKPKTL-KSGKQKNVDKEFHLLATVFDENLSWYLDDNINRYAKQPKSVNKEDAD Q6P3G1_DANRE Q6P3G1_DANRE VGPLLICKPKTL-KSGKQKNVDKEFHLLATVFDENLSWYLDDNINRYAKQPKSVNKEDAD Q90ZT2_DANRE Q90ZT2_DANRE VGPLLICKPKTL-KSGKQKNVDKEFHLLATVFDENLSWYLDDNINRYAKQPKSVNKEDAD A6PYT6_CHIRA A6PYT6_CHIRA MGPLLICRPGSL-KKGVQKNYNKEFHLMATTFDENLSWYLDENKS---TVPGPVTVDDA- Q4T8Z9_TETNG Q4T8Z9_TETNG VGPLLVCRPGSL-KKGVQKNYDKEFHLLATVFDENLSWYLDENILTFTTAPATVNKEEDG B1AJX8_HUMAN B1AJX8_HUMAN VGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEG Q5JZ08_HUMAN Q5JZ08_HUMAN VGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEG HEPH_HUMAN HEPH_HUMAN VGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEG Q1HE23_HUMAN Q1HE23_HUMAN VGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEG HEPH_RAT HEPH_RAT VGPLLVCKAGALGEDGKQKGVDKEFFLLFTIFDENESWYNNANQAAGMLDSRLLSEDVEG A2AI62_MOUSE A2AI62_MOUSE VGPLLVCKAGALGADGKQKGVDKEFFLLFTVFDENESWYNNANQAAGMLDSRLLSEDVEG A2AI63_MOUSE A2AI63_MOUSE VGPLLVCKAGALGADGKQKGVDKEFFLLFTVFDENESWYNNANQAAGMLDSRLLSEDVEG HEPH_MOUSE HEPH_MOUSE VGPLLVCKAGALGADGKQKGVDKEFFLLFTVFDENESWYNSANQAAGMLDSRLLSEDVEG Q4SFU7_TETNG Q4SFU7_TETNG MGPLLVCKKGSLAENGRQKGVDKEFFLLFSVMDENESPYLKENTDQFAPNASVLDEL--- HPHL1_HUMAN HPHL1_HUMAN VGPLLVCKKGVLNADGTQKGIDKEFYLLFTVFDENLSRYFDENIQKFIWHPFSIDKEDKE HPHL1_MOUSE HPHL1_MOUSE VGPLLVCKKGTLNADGTQKGIDKEFYLLFTVFDENFSSYLDENIKKFTWHPFSVDKEDKE MATCH * .. :** . : : :*** * . * : CONSENSUS ?GP???C????L???G?QK?VDKEF?L??TVFDEN?S?????N?????????????????

Q32PR1_DANRE Q32PR1_DANRE FYKSNVMHTINGYVYESGQELGFCHGEIVTWHVSSVGEQDYIQTATFYGHTFELKNREED CERU_SHEEP CERU_SHEEP FQESNKMHSMNGFMYGNQPGLSMCQGDSVMWYLFSAGNEVDIHGIYFSGNTYLSRGERRD A8K5A4_HUMAN A8K5A4_HUMAN FQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGVYFSGNTYLWRGERRD B3KTA8_HUMAN B3KTA8_HUMAN FQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRD B7Z5Q2_HUMAN B7Z5Q2_HUMAN FQESNKMH----------------------W----------------------------- A5PL27_HUMAN A5PL27_HUMAN FQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRD CERU_HUMAN CERU_HUMAN FQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRD Q1L857_HUMAN Q1L857_HUMAN FQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRD CERU_MOUSE CERU_MOUSE FQESNKMHSMNGFMYGNQPGLNMCLGESIVWYLFSAGNEADVHGIYFSGNTYLSKGERRD Q8BV37_MOUSE Q8BV37_MOUSE FQESNKMHSMNGFMYGNQPGLNMCLGESIVWYLFSAGNEADVHGIYFSGNTYLSKGERRD CERU_RAT CERU_RAT FQESNKMHSMNGFMYGNLPGLNMCLGESIVWYLFSAGNEADVHGIYFSGNTYLSKGERRD Q9JL97_RAT Q9JL97_RAT FQESNKMHSMNGFMYGNLPGLNMCLGESIVWYLFSAGNEADVHGIYFSGNTYLSKGERRD Q7ZU12_DANRE Q7ZU12_DANRE FQESNKMHSLNGYMYGNLKGLNMCKGDKVSWHLSGLGSETDIHGLYFEGNRFLYKETRRD Q1MT25_DANRE Q1MT25_DANRE FQESNKMHSLNGYMYGNLKGLNMCKGDKVSWHLSGLGSETDIHGLYFEGNRFLYKETRRD Q6P3G1_DANRE Q6P3G1_DANRE FQESNKMHSLNGYMYGNLKGLNMCKGDKVSWHLSGLGSETDIHGLYFEGNRFLYKETRRD Q90ZT2_DANRE Q90ZT2_DANRE FQESNKMHSLNGYMYGNLKGLNMCKGDKVSWHLSGLGSETDIHGLYFEGNRFLYKETRRD A6PYT6_CHIRA A6PYT6_CHIRA FIESNKMHAINGFVYRNLPGLTMCKGDKVTWHVSGLGTETDVISLYFQGNRFIYRQNRRD Q4T8Z9_TETNG Q4T8Z9_TETNG FIESNKMHAINGFVFGNLPGLTMCKGSKVTWHLSGLGSELDINSLYFQGNRFIYLQNRRD B1AJX8_HUMAN B1AJX8_HUMAN FQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKG Q5JZ08_HUMAN Q5JZ08_HUMAN FQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKG HEPH_HUMAN HEPH_HUMAN FQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKG Q1HE23_HUMAN Q1HE23_HUMAN FQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKG HEPH_RAT HEPH_RAT FEDSNRMHAINGFLFSNLPRLDICKGDTVAWHLLGLGTENDVHGVMFEGNTLQLQGMRKS A2AI62_MOUSE A2AI62_MOUSE FQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFEGNTVQLQGMRKG A2AI63_MOUSE A2AI63_MOUSE FQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFEGNTVQLQGMRKG HEPH_MOUSE HEPH_MOUSE FQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFEGNTVQLQGMRKG Q4SFU7_TETNG Q4SFU7_TETNG FMESNMMHAINGRMYSNLKGLEMCAGDNVMWYTFGLGTEVDIHGVHFEGNTFKKQGTTRD HPHL1_HUMAN HPHL1_HUMAN FVKSNRMHAVNGYMYGNQPGLNMCKRDRVSWHLIGLGTDTDMHGIVFQGNTIHLRGTHRD HPHL1_MOUSE HPHL1_MOUSE FVKSNRMHAVNGYMYGSQPGLSMCKKDRVSWHLIGMGTDTDMHGVYFQGNTIHLRGTHRD MATCH * .** ** * CONSENSUS F??SN?MH??NG????N???L?MC?G??V?W?L???G?E?D?HG??F?GN???????R??

Q32PR1_DANRE Q32PR1_DANRE ILSLFPMTGETITMNMVNIGIWLLASLNSHDSTKGMRVKFKDLECFR------------- CERU_SHEEP CERU_SHEEP TANLFPQTSLSLFMQPDTAGTFDVECLTTDHYTGGMKQKYTVSQCGQRSEDL-YLYLGER A8K5A4_HUMAN A8K5A4_HUMAN TANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSEDS-TFYLGER B3KTA8_HUMAN B3KTA8_HUMAN TANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSEDS-TFYLGER B7Z5Q2_HUMAN B7Z5Q2_HUMAN --------------------TFNVECLTTDHYTGGMKQKYTVNQCRRQSEDS-TFYLGER A5PL27_HUMAN A5PL27_HUMAN TANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSEDS-TFYLGER CERU_HUMAN CERU_HUMAN TANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSEDS-TFYLGER Q1L857_HUMAN Q1L857_HUMAN TANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSEDS-TFYLGER CERU_MOUSE CERU_MOUSE TANLFPHKSLTLLMNPDTKGTFDVECLTTDHYTGGMKQKYTVNQCQRQFEDF-TVYLGER Q8BV37_MOUSE Q8BV37_MOUSE TANLFPHKSLTLLMNPDTKGTFDVECLTTDHYTGGMKQKYTVNQCQRQFEDF-TVYLGER CERU_RAT CERU_RAT TANLFPHKSLTLLMTPDTEGSFDVECLTTDHYTGGMKQKYTVNQCKGQFEDV-TLYQGER Q9JL97_RAT Q9JL97_RAT TANLFPHKSLTLLMTPDTEGSFDVECLTTDHYTGGMKQKYTVNQCKGQFEDV-TLYQGER Q7ZU12_DANRE Q7ZU12_DANRE TINVFPHISHTVIMEPDSMGQFEVNCKTTDHYHGGMRANYTVEKCRFWNRQS-ETMLHQK Q1MT25_DANRE Q1MT25_DANRE TINVFPHISHTVIMEPDSMGQFEVNCKTTDHYHGGMRANYTVEKCRFWNRQS-ETMLHQK Q6P3G1_DANRE Q6P3G1_DANRE TINVFPHISHTVIMEPDSMGQFEVNCKTTDHYHGGMRANYTVEKCRFWNRQS-ETMLHQK Q90ZT2_DANRE Q90ZT2_DANRE TINVFPHISHTVIMEPDSMGQFEVNCKTTDHYHGGMRANYTVEKCRFWNRQS-ETMLHQK A6PYT6_CHIRA A6PYT6_CHIRA TISVFPHISHTVTMEPDSMGQFEVVSATVNQYRAGMRANYTVQKCSLLQRQG-EIMLHSK Q4T8Z9_TETNG Q4T8Z9_TETNG SISVFPHISHTVTMEPDSMGQFEVVSPTVSNYRGGMRANYTVQKCGLFQRQS-EIMLHTK B1AJX8_HUMAN B1AJX8_HUMAN AAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAAR Q5JZ08_HUMAN Q5JZ08_HUMAN AAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAAR HEPH_HUMAN HEPH_HUMAN AAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAAR Q1HE23_HUMAN Q1HE23_HUMAN AAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAAR HEPH_RAT HEPH_RAT AAMLFPHTFVTAIMQPDNPGIFEIYCQAGSHREAGMQAIYNVSQCSSHQDSPRQHYQASR A2AI62_MOUSE A2AI62_MOUSE AVMLFPHTFVTAIMQPDNPGIFEIYCQAGSHREEGMQAIYNVSQCSSHQDSPRQHYQASR A2AI63_MOUSE A2AI63_MOUSE AVMLFPHTFVTAIMQPDNPGIFEIYCQAGSHREEGMQAIYNVSQCSSHQDSPRQHYQASR HEPH_MOUSE HEPH_MOUSE AVMLFPHTFVTAIMQPDNPGIFEIYCQAGSHREEGMQAIYNVSQCSSHQDSPRQHYQASR Q4SFU7_TETNG Q4SFU7_TETNG TLNLFPHTTSAVSMQPKVPGVYEVNCQVTDHYSAGMRQQYTVNRCPQNNFIY-KHTNPTK HPHL1_HUMAN HPHL1_HUMAN SLALFPHMATTAFMQPDHAGIFRVFCATMPHLSRGMGQIYEVSSCDNRDPSE-QRYGMIR HPHL1_MOUSE HPHL1_MOUSE SLALFPHMATTAYMQPDHSGIFKVFCSTLPHFTRGMGQIYEISSCGNRDPSE-PPYGMLR MATCH : : . . ** : * CONSENSUS ????FP???????M?PD??G?F???C????H???GM???Y?V??C???????????????

Q32PR1_DANRE Q32PR1_DANRE ---DYV----IEYD---------------------------------------------- CERU_SHEEP CERU_SHEEP T--YYIAAVEVEWDYSPSRKWEKELHHLQEQ----NLSNAFLDKEEFYIGSKYKKVVYRQ A8K5A4_HUMAN A8K5A4_HUMAN T--YYIAAVEVEWDYSPQREWEKELHHLQEQ----NVSNAFLDKGEFYIGSKYKKVVYRQ B3KTA8_HUMAN B3KTA8_HUMAN T--YYIAAVEVEWDYSPQREWEKELHHLQEQ----NVSNAFLDKGEFYIGSKYKKVVYRQ B7Z5Q2_HUMAN B7Z5Q2_HUMAN T--YYIAAVEVEWDYSPQREWEKELHHLQEQ----NVSNAFLDKGEFYIGSKYKKVVYRQ A5PL27_HUMAN A5PL27_HUMAN T--YYIAAVEVEWDYSPQREWEKELHHLQEQ----NVSNAFLDKGEFYIGSKYKKVVYRQ CERU_HUMAN CERU_HUMAN T--YYIAAVEVEWDYSPQREWEKELHHLQEQ----NVSNAFLDKGEFYIGSKYKKVVYRQ Q1L857_HUMAN Q1L857_HUMAN T--YYIAAVEVEWDYSPQREWEKELHHLQEQ----NVSNAFLDKGEFYIGSKYKKVVYRQ CERU_MOUSE CERU_MOUSE T--YYVAAVEVEWDYSPSRAWEKELHHLQEQ----NVSNVFLDKEEFFIGSKYKKVVYRQ Q8BV37_MOUSE Q8BV37_MOUSE T--YYVAAVEVEWDYSPSRAWEKELHHLQEQ----NVSNVFLDKEEFFIGSKYKKVVYRQ CERU_RAT CERU_RAT T--YYIAAVEVEWDYSPSRDWEMELHHLQEQ----NVSNAFLDKEEFFIGSKYKKVVYRE Q9JL97_RAT Q9JL97_RAT T--YYIAAVEVEWDYSPSRDWEMELHHLQEQ----NVSNAFLDKEEFFIGSKYKKVVYRE Q7ZU12_DANRE Q7ZU12_DANRE K--YYIAAVEMDWDYSPTRTWEDKMHNGLKE----SPGNEFLKKEGKFIGSKYKKVLYKE Q1MT25_DANRE Q1MT25_DANRE K--YYIAAVEMDWDYSPTRTWEDKMHNGLKE----SPGNEFLKKEGKFIGSKYKKVLYKE Q6P3G1_DANRE Q6P3G1_DANRE K--YYIAAVEMDWDYSPTRTWEDKMHNGLKE----SPGNEFLKKEGKFIGSKYKKVLYKE Q90ZT2_DANRE Q90ZT2_DANRE K--YYIAAVEMDWDYSPTRTWEDKMHNGLKE----SPGNEFLKKEGKFIGSKYKKVLYKE A6PYT6_CHIRA A6PYT6_CHIRA T--YYIAAMEVDWNYSPNRTWETEMFGGQDS-----PAPAFLDQQGGFIGSSYKKVVYLR Q4T8Z9_TETNG Q4T8Z9_TETNG T--YYIAAVEVEWDYSLSRTWETELYRGQEKYAYFHPASVFLDKQAGFIGSRYKKVVYRQ B1AJX8_HUMAN B1AJX8_HUMAN I--YYIMAEEVEWDYCPDRSWEREWHNQSEK---DSYGYIFLSNKDGLLGSRYKKAVFRE Q5JZ08_HUMAN Q5JZ08_HUMAN I--YYIMAEEVEWDYCPDRSWEREWHNQSEK---DSYGYIFLSNKDGLLGSRYKKAVFRE HEPH_HUMAN HEPH_HUMAN I--YYIMAEEVEWDYCPDRSWEREWHNQSEK---DSYGYIFLSNKDGLLGSRYKKAVFRE Q1HE23_HUMAN Q1HE23_HUMAN I--YYIMAEEVEWDYCPDRSWEREWHNQSEK---DSYGYIFLSNKDGLLGSRYKKAVFRE HEPH_RAT HEPH_RAT V--YYIMAEEIEWDYCPDRSWELEWYNTSEK---DSYGHVFLSNKDGLLGSKYKKAVFRE A2AI62_MOUSE A2AI62_MOUSE V--YYIMAEEIEWDYCPDRSWELEWHNTSEK---DSYGHVFLSNKDGLLGSKYKKAVFRE A2AI63_MOUSE A2AI63_MOUSE V--YYIMAEEIEWDYCPDRSWELEWHNTSEK---DSYGHVFLSNKDGLLGSKYKKAVFRE HEPH_MOUSE HEPH_MOUSE V--YYIMAEEIEWDYCPDRSWELEWHNTSEK---DSYGHVFLSNKDGLLGSKYKKAVFRE Q4SFU7_TETNG Q4SFU7_TETNG VVQYFISAEEIEWDYSPQRHWEQELHNTKNS-----PGDKYLEKGKYRIGSRYKKVVYRE HPHL1_HUMAN HPHL1_HUMAN T--FYIAAEEVEWDYAPNKNWEFEKQHVDAR--GERHGDIFMNRTENWIGSQYKKVVYRE HPHL1_MOUSE HPHL1_MOUSE T--FFIAAEEVEWDYAPNKNWEFEKQHLDAG--GERHGDIFMNHTENWIGSQYRKVVYRE MATCH :: :::: CONSENSUS ???YYI?A?E?EWDY?P?R?WE?E????????????????FL???????GS?YKK?V???

Q32PR1_DANRE Q32PR1_DANRE YEDGKFTA---------------------------------------------------- CERU_SHEEP CERU_SHEEP FTDSTFQVPVERKGEEEHLGIL--------------------------GPQLHADVGDKV A8K5A4_HUMAN A8K5A4_HUMAN YTDSTFRVPVERKAEEEHLGIL--------------------------GPQLHADVGDKV B3KTA8_HUMAN B3KTA8_HUMAN YTDSTFRVPVERKAEEEHLGIL--------------------------GPQLHADVGDKV B7Z5Q2_HUMAN B7Z5Q2_HUMAN YTDSTFRVPVERKAEEEHLGIL--------------------------GPQLHADVGDKV A5PL27_HUMAN A5PL27_HUMAN YTDSTFRVPVERKAEEEHLGIL--------------------------GPQLHADVGDKV CERU_HUMAN CERU_HUMAN YTDSTFRVPVERKAEEEHLGIL--------------------------GPQLHADVGDKV Q1L857_HUMAN Q1L857_HUMAN YTDSTFRVPVERKAEEEHLGIL--------------------------GPQLHADVGDKV CERU_MOUSE CERU_MOUSE FTDSSFREQVKRRAEDEHLGIL--------------------------GPPIHANVGDKV Q8BV37_MOUSE Q8BV37_MOUSE FTDSSFREQVKRRAEDEHLGIL--------------------------GPPIHANVGDKV CERU_RAT CERU_RAT FTDSTFREQVKRRAEEEHLGML--------------------------GPLIHADVGAKV Q9JL97_RAT Q9JL97_RAT FTDSTFREQVKRRAEEEHLGIL--------------------------GPLIHADVGDKV Q7ZU12_DANRE Q7ZU12_DANRE YTDETFTKLKERTADMEHLGIM--------------------------GPMIHGKVGEKV Q1MT25_DANRE Q1MT25_DANRE YTDETFTKLKERTADMEHLGIM--------------------------GPMIHGKVGEKV Q6P3G1_DANRE Q6P3G1_DANRE YTDETFTKLKERTADMEHLGIM--------------------------GPMIHGKVGEKV Q90ZT2_DANRE Q90ZT2_DANRE YTDETFTKLKERTADMEHLGIM--------------------------GPMIHGKVGEKV A6PYT6_CHIRA A6PYT6_CHIRA FTNKKFTQQMERAADMEHLGIL--------------------------GPMIRADVGDKI Q4T8Z9_TETNG Q4T8Z9_TETNG FTCGKFITQVERTADMEHLGIM--------------------------GPMIHANVGDKV B1AJX8_HUMAN B1AJX8_HUMAN YTDGTFRIPRPRTGPEEHLGIL--------------------------GPLIKGEVGDIL Q5JZ08_HUMAN Q5JZ08_HUMAN YTDGTFRIPRPRTGPEEHLGIL--------------------------GPLIKGEVGDIL HEPH_HUMAN HEPH_HUMAN YTDGTFRIPRPRTGPEEHLGIL--------------------------GPLIKGEVGDIL Q1HE23_HUMAN Q1HE23_HUMAN YTDGTFRIPRPRTGPEEHLGIL--------------------------GPLIKGEVGDIL HEPH_RAT HEPH_RAT YTDGTFRIPQPRSGPEEHLGIL--------------------------GPLIRGEVGDIL A2AI62_MOUSE A2AI62_MOUSE YTDGTFRIPRPRSGPEEHLGIL--------------------------GPLIRGEVGDIL A2AI63_MOUSE A2AI63_MOUSE YTDGTFRIPRPRSGPEEHLGIL--------------------------GPLIRGEVGDIL HEPH_MOUSE HEPH_MOUSE YTDGTFRIPRPRSGPEEHLGIL--------------------------GPLIRGEVGDIL Q4SFU7_TETNG Q4SFU7_TETNG YTDDTFSVQKKRQASQKHLGILGTVRFYFLLFVFVETRNDNFFVFTCIGPIIRAEVGEQI HPHL1_HUMAN HPHL1_HUMAN YTDGEFVEIKARPPREEHLELL--------------------------GPMIHAEVGNTV HPHL1_MOUSE HPHL1_MOUSE YTNGEFVEIKARPPQEEHLQLL--------------------------GPMIHAEVGDSI MATCH : * CONSENSUS ?TD??F?????R????EHLGI???????????????????????????GP?????VG???

Q32PR1_DANRE Q32PR1_DANRE -------------------------------------------WKPP------------- CERU_SHEEP CERU_SHEEP NIIFKNMATRPYSIHAHGVKTESSTVTPT-----APGETRTYIWKIPERSGAGMGDSPCI A8K5A4_HUMAN A8K5A4_HUMAN KIIFKNMATRPYSIHAHGVQTESSTVTPT-----LPGETLTYVWKIPERSGAGTEDSACI B3KTA8_HUMAN B3KTA8_HUMAN KIIFKNMATRPYSIHAHGVQTESSTVTPT-----LPGETLTYVWKIPERSGAGTEDSACI B7Z5Q2_HUMAN B7Z5Q2_HUMAN KIIFKNMATRPYSIHAHGVQTESSTVTPT-----LPGETLTYVWKIPERSGAGTEDSACI A5PL27_HUMAN A5PL27_HUMAN KIIFKNMATRPYSIHAHGVQTESSTVTPT-----LPGETLTYVWKIPERSGAGTEDSACI CERU_HUMAN CERU_HUMAN KIIFKNMATRPYSIHAHGVQTESSTVTPT-----LPGETLTYVWKIPERSGAGTEDSACI Q1L857_HUMAN Q1L857_HUMAN KIIFKNMATRPYSIHAHGVQTESSTVTPT-----LPGETLTYVWKIPERSGAGTEDSACI CERU_MOUSE CERU_MOUSE KVVFKNMATRPYSIHAHGVKTESSTVVPT-----LPGEVRTYTWQIPERSGAGREDSACI Q8BV37_MOUSE Q8BV37_MOUSE KVVFKNMATRPYSIHAHGVKTESSTVVPT-----LPGEVRTYTWQIPERSGAGREDSACI CERU_RAT CERU_RAT KVVFKNMATRPYSIHAHGVKTKSSTVAPT-----LPGEVRTYIWQIPERSGAGTEDSPCI Q9JL97_RAT Q9JL97_RAT KVAFKNMASRPYSIHAHGVKTKSSTVTPT-----LPGEVRTYIWQIPERSGAGTEDSPCI Q7ZU12_DANRE Q7ZU12_DANRE KIVFKNMARRPYSIHAHGVKTDSPQVPLT-----RPGETQTYTWYLPKNSGPTEEQEECS Q1MT25_DANRE Q1MT25_DANRE KIVFKNMARRPYSIHAHGVKTDSPQVALT-----RPGETQTYTWYLPKNSGPTEEQEECS Q6P3G1_DANRE Q6P3G1_DANRE KIVFKNMARRPYSIHAHGVKTDSPQVALT-----RPGETQTYTWYLPKNSGPTEEQEECS Q90ZT2_DANRE Q90ZT2_DANRE KIVFKNMARRPYSIHAHGVKTDSPQVALT-----RPGETQTYTWYLPKNSGPTEEQEECS A6PYT6_CHIRA A6PYT6_CHIRA TVVFKNMASRPYSIHAHGVKTETPAVHLT-----QPGETHSYYWYVTKNTGPTPEQEQCT Q4T8Z9_TETNG Q4T8Z9_TETNG KVVFKNMASRPYSIHAHGVKTDTPDVHHT-----KPGETYTYYWYVTKNTGPTAEQEECS B1AJX8_HUMAN B1AJX8_HUMAN TVVFKNNASRPYSVHAHGV-LESTTVWPL---AAEPGEVVTYQWNIPERSGPGPNDSACV Q5JZ08_HUMAN Q5JZ08_HUMAN TVVFKNNASRPYSVHAHGV-LESTTVWPL---AAEP------------------------ HEPH_HUMAN HEPH_HUMAN TVVFKNNASRPYSVHAHGV-LESTTVWPL---AAEPGEVVTYQWNIPERSGPGPNDSACV Q1HE23_HUMAN Q1HE23_HUMAN TVVFKNNASRPYSVHAHGV-LESTTVWPL---AAEPGEVVTYQWNIPERSGPGPNDSACV HEPH_RAT HEPH_RAT TVVFKNKASRPYSIHAHGV-LESSTGWPQ---AAEPGEVLTYQWNIPERSGPGPSDSACV A2AI62_MOUSE A2AI62_MOUSE TVVFKNKASRPYSIHAHGV-LESNTGGPQ---AAEPGEL--------------------- A2AI63_MOUSE A2AI63_MOUSE TVVFKNKASRPYSIHAHGV-LESNTGGPQ---AAEPGEVLTYQWNIPERSGPGPSDSACV HEPH_MOUSE HEPH_MOUSE TVVFKNKASRPYSIHAHGV-LESNTGGPQ---AAEPGEVLTYQWNIPERSGPGPSDSACV Q4SFU7_TETNG Q4SFU7_TETNG VITLKNKASRPYSITAHGV-KASGVRSPV-----KPGHIIELTWDVLESSGPGVSDPNCI HPHL1_HUMAN HPHL1_HUMAN LIIFKNKASRPYSISAQGV-EEMDSGKQFQVPMTKPGEVKTYRWNIPKRSGPGPSDPNCI HPHL1_MOUSE HPHL1_MOUSE LIIFKNKASRPYSIAAQGV-EDSNNGKLLNVPVTKPGEIKTYRWNVPKRSGPGPSDPNCI MATCH CONSENSUS ???FKN?A?RPYSIHAHGV???S????????????PGE??TY?W??P??SG???????C?

Q32PR1_DANRE Q32PR1_DANRE ------TINEIK--------------------------KKKK------------------ CERU_SHEEP CERU_SHEEP PWVYYSTVDRVKDLFSGLIGPLIVCRKHYLKVSN-----PIKKLEFSLLFLVFDENESWY A8K5A4_HUMAN A8K5A4_HUMAN PWAYYSTVDQVKDLYSGLIGPLIVCRRPYLKVFN-----PRRKLEFALLFLVFDENESWY B3KTA8_HUMAN B3KTA8_HUMAN PWAYYSTVDQVKDLYSGLIGPLIVCRRPYLKVFN-----PRRKLEFALLFLVFDENESWY B7Z5Q2_HUMAN B7Z5Q2_HUMAN PWAYYSTVDQVKDLYSGLIGPLIVCRRPYLKVFN-----PRRKLEFALLFLVFDENESWY A5PL27_HUMAN A5PL27_HUMAN PWAYYSTVDQVKDLYSGLIGPLIVCRRPYLKVFN-----PRRKLEFALLFLVFDENESWY CERU_HUMAN CERU_HUMAN PWAYYSTVDQVKDLYSGLIGPLIVCRRPYLKVFN-----PRRKLEFALLFLVFDENESWY Q1L857_HUMAN Q1L857_HUMAN PWAYYSTVDQVKDLYSGLIGPLIVCRRPYLKVFN-----PRRKLEFALLFLVFDENESWY CERU_MOUSE CERU_MOUSE PWAYYSTVDRVKDLYSGLIGPLIVCRKSYVKVFS-----PKKKMEFFLLFLVFDENESWY Q8BV37_MOUSE Q8BV37_MOUSE PWAYYSTVDRVKDLYSGLIGPLIVCRKSYVKVFS-----PKKKMEFFLLFLVFDENESWY CERU_RAT CERU_RAT PWAYYSTVDRVKDLYSGLIGPLIVCRKSYVKVFN-----PKKKMEFSLLFLVFDENESWY Q9JL97_RAT Q9JL97_RAT PWAYYSTVDRVKDLYSGLIGPLIVCRKSYVKVFN-----PKKKMEYSLLFLVFDENESWY Q7ZU12_DANRE Q7ZU12_DANRE VGAYYSTVDVIKDMYSGLVGPLVICKKSLARTLG----LKKEVEEFALLFMVFDENESWY Q1MT25_DANRE Q1MT25_DANRE VGAYYSTVDVIKDMYSGLVGPLVICKKSLARTLG----LKKEVEEFALLFMVFDENESWY Q6P3G1_DANRE Q6P3G1_DANRE VGAYYSTVDVIKDMYSGLVGPLVICKKSLARTLG----LKKEVEEFALLFMVFDENESWY Q90ZT2_DANRE Q90ZT2_DANRE VGAYYSTVDVIKDMYSGLVGPLVICKKSLARTLG----LKKEVEEFALLFMVFDENESWY A6PYT6_CHIRA A6PYT6_CHIRA VSAYYSTADVTKDMYSGLIGPLVICRRSWGRSFG----VRKEVEEFALLFLIFDENESWY Q4T8Z9_TETNG Q4T8Z9_TETNG VSAYYSAVDVVKDLYSGLVGPLVICRRSWARTLG----IKKEIDEFALLFLVFDENESWY B1AJX8_HUMAN B1AJX8_HUMAN SWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGG---RSDMDREFALLFLIFDENKSWY Q5JZ08_HUMAN Q5JZ08_HUMAN ------------------------------------------------------------ HEPH_HUMAN HEPH_HUMAN SWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGG---RSDMDREFALLFLIFDENKSWY Q1HE23_HUMAN Q1HE23_HUMAN SWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGG---RSDMDREFALLFLIFDENKSWY HEPH_RAT HEPH_RAT SWIYYSAVDPIKDMYSGLVGPLVICRNGILEPNGG---RNDMDREFALLFLIFDENQSWY A2AI62_MOUSE A2AI62_MOUSE --------------------EHLMKRQRLYNP-------------FTLVF--------WF A2AI63_MOUSE A2AI63_MOUSE SWIYYSAVDPIKDMYSGLVGPLVICRNGILEPNGG---RNDMDREFALLFLIFDENQSWY HEPH_MOUSE HEPH_MOUSE SWIYYSAVDPIKDMYSGLVGPLVICRNGILEPNGG---RNDMDREFALLFLIFDENQSWY Q4SFU7_TETNG Q4SFU7_TETNG SYPYYSNVNFIKDLYSGLLGPLVICRPGTLKGQGSERQRTDVDKEFALLFVVHDENQSWY HPHL1_HUMAN HPHL1_HUMAN PWVYYSTVNFVKDTYSGLMGPLITCRKGVLNEKGR---RSDVDYEFALLFLVFNENESWY HPHL1_MOUSE HPHL1_MOUSE PWVYFSTANFVKDTYSGLMGPLITCREGVLNEKGR---RSDVDYEFALLFLVFNENESWY MATCH CONSENSUS ???YYS?V???KD?YSGL?GPL??C???????????????????EF?LLF??FDEN?SWY

Q32PR1_DANRE Q32PR1_DANRE ------------------------------------------------------------ CERU_SHEEP CERU_SHEEP LDDNIKTY-SDHPEKVDKANEEFMESNKMHAINGRMFGNLQGLTMHV-----------GN A8K5A4_HUMAN A8K5A4_HUMAN LDDNIKTY-SDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGN B3KTA8_HUMAN B3KTA8_HUMAN LDDNIKTY-SDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGN B7Z5Q2_HUMAN B7Z5Q2_HUMAN LDDNIKTY-SDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGN A5PL27_HUMAN A5PL27_HUMAN LDDNIKTY-SDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGN CERU_HUMAN CERU_HUMAN LDDNIKTY-SDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGN Q1L857_HUMAN Q1L857_HUMAN LDDNIKTY-SDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGN CERU_MOUSE CERU_MOUSE LDDNIKTY-SEHPEKVNKDNEEFLESNKMHAINGKMFGNLQGLTMHVKDEVNWYVMGMGN Q8BV37_MOUSE Q8BV37_MOUSE LDDNIKTY-SEHPEKVNKDNEEFLESNKMHAINGKMFGNLQGLTMHVKDEVNWYVMGMGN CERU_RAT CERU_RAT LDDNINTY-PDHPEKDNKDNEEFIESNKMHAINGKMFGNLQGLTMHVGDEVNWYVMAMGN Q9JL97_RAT Q9JL97_RAT LDDNINTY-SDHPEKVNKDNEEFIESNKMHAINGKMFGNLQGLTMHVGDEVNWYVMAMGN Q7ZU12_DANRE Q7ZU12_DANRE LEENIKTH-VKNPPKALTEDQQFIESNKMHGINGLVFGNLKGLNMKVGDKVYWYLMGLGN Q1MT25_DANRE Q1MT25_DANRE LEENIKTH-VKNPPKALTEDQQFIESNKMHGINGLVFGNLKGLNMKVGDKVYWYLMGLGN Q6P3G1_DANRE Q6P3G1_DANRE LEENIKTH-VKNPPKALTEDQQFIESNKMHGINGLVFGNLKGLNMKVGDKVYWYLMGLGN Q90ZT2_DANRE Q90ZT2_DANRE LEENIKTH-VKNPPKALTEDQQFIESNKMHGINGLVFGNLKGLNMKVGDKVYWYLMGLGN A6PYT6_CHIRA A6PYT6_CHIRA LDENIRTH-IRNPRPNLKDDETFIESNKMHAVNGYMYANLNGLNMEVGDKVYWYLMGMGN Q4T8Z9_TETNG Q4T8Z9_TETNG LDENIRRH-VRNPPTNLKDDETFIESNKMHAINGHMYNNLNGLNMEVGDKVYWYLMGMGT B1AJX8_HUMAN B1AJX8_HUMAN LEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQ Q5JZ08_HUMAN Q5JZ08_HUMAN ------------------------------------------------------------ HEPH_HUMAN HEPH_HUMAN LEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQ Q1HE23_HUMAN Q1HE23_HUMAN LEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQ HEPH_RAT HEPH_RAT LKENIATYGPQETSHVNLQDATFLESNKMHAINGKLYANLRGLTVYQGERVAWYMLAMGQ A2AI62_MOUSE A2AI62_MOUSE IPFNI-----------------------LHSWAGQVT----------------------- A2AI63_MOUSE A2AI63_MOUSE LKENIATYGPQESSHVNLKDATFLESNKMHAINGKLYANLRGLTVYQGERVAWYMLAMGQ HEPH_MOUSE HEPH_MOUSE LKENIATYGPQESSHVNLKDATFLESNKMHAINGKLYANLRGLTVYQGERVAWYMLAMGQ Q4SFU7_TETNG Q4SFU7_TETNG LDENIQNYLNVEPHNFDQDDG-FLESNMMHGINGRVFANLQGLEMTQGQKVTWYLLGMGN HPHL1_HUMAN HPHL1_HUMAN LDDNIKKYLNKDPRDFKRTDD-FEESNRMHAINGKIFGNLHGLIMNEDTMTNWYLLGIGS HPHL1_MOUSE HPHL1_MOUSE LDDNIKKYLNKDPRDFKHTDD-FEESNKMHAINGKIFGNLPGLIMTEDSMTNWYLLGIGS MATCH CONSENSUS L??NI?????????????????F?ESNKMH?ING????NL?GL?????????WY????G?

Q32PR1_DANRE Q32PR1_DANRE ------------------------------------------------------------ CERU_SHEEP CERU_SHEEP EVDLHSVHFHGHSFQYQH-RGIYTSDVFDLFPGTYQTLEMTPKTPGIWLLHCHVTDHIHA A8K5A4_HUMAN A8K5A4_HUMAN EIDLHTVHFHGHSFQYKH-RGVYSSDVFDIFPGTYQTLEMFPRTPGIWLLHCHVTDHFHA B3KTA8_HUMAN B3KTA8_HUMAN EIDLHTVHFHGHSFQYKH-RGVYSSDVFDIFPGTYQTLEMFPRTPGIWLLHCHVTDHIHA B7Z5Q2_HUMAN B7Z5Q2_HUMAN EIDLHTVHFHGHSFQYKH----------------------LLRLTGEYGM---------- A5PL27_HUMAN A5PL27_HUMAN EIDLHTVHFHGHSFQYKH-RGVYSSDVFDIFPGTYQTLEMFPRTPGIWLLHCHVTDHIHA CERU_HUMAN CERU_HUMAN EIDLHTVHFHGHSFQYKH-RGVYSSDVFDIFPGTYQTLEMFPRTPGIWLLHCHVTDHIHA Q1L857_HUMAN Q1L857_HUMAN EIDLHTVHFHGHSFQYK------------------------------------------- CERU_MOUSE CERU_MOUSE EIDLHTVHFHGHSFQYKH-RGVYSSDVFDLFPGTYQTLEMFPQTPGTWLLHCHVTDHVHA Q8BV37_MOUSE Q8BV37_MOUSE EIDLHTVHFHGHSFQYKH-RGVYSSDVFDLFPGTYQTLEMFPQTPGTWLLHCHVTDHVHA CERU_RAT CERU_RAT EIDLHTVHFHGHSFQYKH-RGIHSSDVFDFFPGTYQTLEMFPQTPGTWLLHCHVTDHIHA Q9JL97_RAT Q9JL97_RAT EIDLHTVHFHGHSFQYKH-RGIHSSDVFDLFPGTYQTLEMFPQTPGTWLLHCHVTDHIHA Q7ZU12_DANRE Q7ZU12_DANRE EVDIHTAHFHGHSFDYKV-SGTHRADVFDLVPGTFQTVTMRPLYSGTWLLHCHVTDHIQA Q1MT25_DANRE Q1MT25_DANRE EVDIHTAHFHGHSFDYKV-SGTHRADVFDLVPGTFQTVTMRPLYSGTWLLHCHVTDHIQA Q6P3G1_DANRE Q6P3G1_DANRE EVDIHTAHFHGHSFDYKV-SGTHRADVFDLVPGTFQTVTMRPLYSGTWLLHCHVTDHIQA Q90ZT2_DANRE Q90ZT2_DANRE EVDIHTAHFHGHSFDYKV-SGTHRADVFDLVPGTFQTVTMRPLYSGTWLLHCHVTDHIQA A6PYT6_CHIRA A6PYT6_CHIRA DVDIHSAHWHGHTVEYKLGGGPHRTDVYELFPAAFQTVKMHPQYPGTWLLHCHVTDHIKG Q4T8Z9_TETNG Q4T8Z9_TETNG DVDIHSVHWHGHSAEYKLGGGPHRTDVYELFPATFQTVKMRPEFPGTWLLHCHVTDHIKA B1AJX8_HUMAN B1AJX8_HUMAN DVDLHTIHFHAESFLYRN-GENYRADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHA Q5JZ08_HUMAN Q5JZ08_HUMAN ------------------------------------------------------------ HEPH_HUMAN HEPH_HUMAN DVDLHTIHFHAESFLYRN-GENYRADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHA Q1HE23_HUMAN Q1HE23_HUMAN DVDLHTIHFHAESFLYRN-GENYRADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHA HEPH_RAT HEPH_RAT DTDIHTVHFHAESFLYQN-GHSYRADVVDLFPGTFEVVEMVASNPGAWLMHCHVTDHVHA A2AI62_MOUSE A2AI62_MOUSE ------------------------------------------------------------ A2AI63_MOUSE A2AI63_MOUSE DTDIHTVHFHAESFLYQN-GQSYRADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHA HEPH_MOUSE HEPH_MOUSE DTDIHTVHFHAESFLYQN-GQSYRADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHA Q4SFU7_TETNG Q4SFU7_TETNG EVDVHTVHFHAETFIYKT-HSMHRADVFDLFPGTVQTVEMVARNPGTWLLHCHVTDHIQS HPHL1_HUMAN HPHL1_HUMAN EVDIHTIHYHAESFLFKI-DKSYREDVYDLFPGTFQTIELFADHPGTWLLHCHVSDHIHA HPHL1_MOUSE HPHL1_MOUSE EVDIHTIHYHAESFLFKI-DKSYREDVYDLFPGTFQTIELFADHPGTWLLHCHVSDHIHA MATCH CONSENSUS ??D?H??H?H??SF?Y?????????DV????P?????????????G?WL?HCHV?DH???

Q32PR1_DANRE Q32PR1_DANRE ------------------------------------------------------------ CERU_SHEEP CERU_SHEEP GMETTYTVLP-NEEIKSG------------------------------------------ A8K5A4_HUMAN A8K5A4_HUMAN GMETTYTVLQ-NEDTKSG------------------------------------------ B3KTA8_HUMAN B3KTA8_HUMAN GMETTYTVLQ-NEDTKSG------------------------------------------ B7Z5Q2_HUMAN B7Z5Q2_HUMAN ------------------------------------------------------------ A5PL27_HUMAN A5PL27_HUMAN GMETTYTVLQ-NEDTKSG------------------------------------------ CERU_HUMAN CERU_HUMAN GMETTYTVLQ-NEDTKSG------------------------------------------ Q1L857_HUMAN Q1L857_HUMAN ------------------------------------------------------------ CERU_MOUSE CERU_MOUSE GMATTYTVLPVEQETKSG------------------------------------------ Q8BV37_MOUSE Q8BV37_MOUSE GMATTYTVLPVEQETKSG------------------------------------------ CERU_RAT CERU_RAT GMVTTYTVLP-NQETKSG------------------------------------------ Q9JL97_RAT Q9JL97_RAT GMVTTYTVLP-NQASSQSYRMTWNILYTLLISMTTLFQISTKE----------------- Q7ZU12_DANRE Q7ZU12_DANRE GMETTYTVLE-KDGRKRGFLGIFGSG---------------------------------- Q1MT25_DANRE Q1MT25_DANRE GMETTYTVLE-KDGRKRGFLGIFGSG---------------------------------- Q6P3G1_DANRE Q6P3G1_DANRE GMETTYTVLE-KDGRKRGFLGIFGSG---------------------------------- Q90ZT2_DANRE Q90ZT2_DANRE GMETTYTVLE-KDGRKRGFLGIFGSG---------------------------------- A6PYT6_CHIRA A6PYT6_CHIRA GMEALYTVTE--KAKKTGLFG--------------------------------------- Q4T8Z9_TETNG Q4T8Z9_TETNG GMVTTYTVT--------------------------------------------------- B1AJX8_HUMAN B1AJX8_HUMAN GMETLFTVFS-RTEHLSPLTVITK-----ETEKAVPPRDIEEGNVKMLGMQIPIKNVEML Q5JZ08_HUMAN Q5JZ08_HUMAN ------------------------------------------------------------ HEPH_HUMAN HEPH_HUMAN GMETLFTVFS-RTEHLSPLTVITK-----ETEKAVPPRDIEEGNVKMLGMQIPIKNVEML Q1HE23_HUMAN Q1HE23_HUMAN GMETLFTVFS-RTEHLSPLTVITK-----ETEKAVPPRDIEEGNVKMLGMQIPIKNVEML HEPH_RAT HEPH_RAT GMETIFTVLS-HEEHFSTMTTITK-----EIGKAVILQNIGEGNVKMLGMNIPVKNVEIL A2AI62_MOUSE A2AI62_MOUSE ------------------------------------------------------------ A2AI63_MOUSE A2AI63_MOUSE GMETIFTVLS-HEEHFSTMTTITK-----EIGKAVILRDIGGDNVKMLGMNIPIKDVEIL HEPH_MOUSE HEPH_MOUSE GMETIFTVLS-HEEHFSTMTTITK-----EIGKAVILRDIGGDNVKMLGMNIPIKDVEIL Q4SFU7_TETNG Q4SFU7_TETNG GMETTFMIK--------------------------------------------------- HPHL1_HUMAN HPHL1_HUMAN GMETTYTVLR-NIDNRIPYSTTSP-GVASHPATVPSNERPGKEQLYFFGKNLGPTGAKAA HPHL1_MOUSE HPHL1_MOUSE GMETTYTVLR-NIDNRIPYSTKTPSGAGSHAVTVPSQEQPGKEELYFFGKNLRPRGAKAA MATCH CONSENSUS GM??????????????????????????????????????????????????????????

Q32PR1_DANRE Q32PR1_DANRE -------------------------------------------------- CERU_SHEEP CERU_SHEEP -------------------------------------------------- A8K5A4_HUMAN A8K5A4_HUMAN -------------------------------------------------- B3KTA8_HUMAN B3KTA8_HUMAN -------------------------------------------------- B7Z5Q2_HUMAN B7Z5Q2_HUMAN -------------------------------------------------- A5PL27_HUMAN A5PL27_HUMAN -------------------------------------------------- CERU_HUMAN CERU_HUMAN -------------------------------------------------- Q1L857_HUMAN Q1L857_HUMAN -------------------------------------------------- CERU_MOUSE CERU_MOUSE -------------------------------------------------- Q8BV37_MOUSE Q8BV37_MOUSE -------------------------------------------------- CERU_RAT CERU_RAT -------------------------------------------------- Q9JL97_RAT Q9JL97_RAT -------------------------------------------------- Q7ZU12_DANRE Q7ZU12_DANRE -------------------------------------------------- Q1MT25_DANRE Q1MT25_DANRE -------------------------------------------------- Q6P3G1_DANRE Q6P3G1_DANRE -------------------------------------------------- Q90ZT2_DANRE Q90ZT2_DANRE -------------------------------------------------- A6PYT6_CHIRA A6PYT6_CHIRA -------------------------------------------------- Q4T8Z9_TETNG Q4T8Z9_TETNG -------------------------------------------------- B1AJX8_HUMAN B1AJX8_HUMAN ASVLVAISVTLLLVVLALGGVVWYQHRQRKLRRNRRSILDDSFKLLSFKQ Q5JZ08_HUMAN Q5JZ08_HUMAN -------------------------------------------------- HEPH_HUMAN HEPH_HUMAN ASVLVAISVTLLLVVLALGGVVWYQHRQRKLRRNRRSILDDSFKLLSFKQ Q1HE23_HUMAN Q1HE23_HUMAN ASVLVAISVTLLLVVLALGGVVWYQHRQRKLRRNRRSILDDSFKLLSFKQ HEPH_RAT HEPH_RAT SSALIAICVVLLLIALALGGVVWYQHRQRKLRRNRRSILDDSFKLLSLKQ A2AI62_MOUSE A2AI62_MOUSE -------------------------------------------------- A2AI63_MOUSE A2AI63_MOUSE SSALIAICVLLLLIALALGGVVWYQHRQRKLRRNRRSILDDSFKLLSLKQ HEPH_MOUSE HEPH_MOUSE SSALIAICVLLLLIALALGGVVWYQHRQRKLRRNRRSILDDSFKLLSLKQ Q4SFU7_TETNG Q4SFU7_TETNG -------------------------------------------------- HPHL1_HUMAN HPHL1_HUMAN LVILFIIGLLLLITTVILSLRLCSAMKQTDYQQVQSCALPTDAL------ HPHL1_MOUSE HPHL1_MOUSE LVILFILGLLLLVATVVLALRLRSSRRQMAYREVQSCALPTDAL------ MATCH CONSENSUS ??????????????????????????????????????????????????


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