Alignment of the gene Family HBG003760 of HOVERGEN

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Isoforms are ON
Q4SYI4_TETNG Q4SYI4_TETNG ------------------------------------------------------------ A7E3L2_CHICK A7E3L2_CHICK ------------------------------------------------------------ B2RSM1_MOUSE B2RSM1_MOUSE AVSWRS---------------------WLANEGVKHLCLLIWLSLNVLLFWKTFLLYNQG NOX4_MOUSE NOX4_MOUSE AVSWRS---------------------WLANEGVKHLCLLIWLSLNVLLFWKTFLLYNQG NOX4_RAT NOX4_RAT ALSWRS---------------------WLANEGVKHLCLLVWLSLNVLLFWKTFLLYNQG NOX4_PONAB NOX4_PONAB AVSWRS---------------------WLANEGVKHLCLFIWLSMNVLLFWKTFLLYNQG NOX4_HUMAN NOX4_HUMAN AVSWRS---------------------WLANEGVKHLCLFIWLSMNVLLFWKTFLLYNQG B7Z520_HUMAN B7Z520_HUMAN --------------------------------------------MNVLLFWKTFLLYNQG B3KQ17_HUMAN B3KQ17_HUMAN --------------------------------------------MNVLLFWKTFLLYNQG B7Z523_HUMAN B7Z523_HUMAN GEMWRKREEVIFREYSFSFYPLNIFALFILFPDYFCLLGFIWLSMNVLLFWKTFLLYNQG B7Z529_HUMAN B7Z529_HUMAN ---------------------------------------------MLSAVTDLGSIESTV B7Z535_HUMAN B7Z535_HUMAN ------------------------------------------------------------ A3FEK2_SHEEP A3FEK2_SHEEP ------------------------------------------------------------ Q6V1P7_BOVIN Q6V1P7_BOVIN -----------------------------ANEGVKHLCLLIWLSLNVLLFWKTFLLYNQG A7E3L0_CIOIN A7E3L0_CIOIN NARLNG---------------------FLVNEFPKYIVFLLWLGLNGFLFGYYYNFYNTK NOX3_MOUSE NOX3_MOUSE --MPVC---------------------WILNESGSFVVALLWLAVNAYLFIDTFFWYTEE NOX3_RAT NOX3_RAT --MPTC---------------------WILNESVSFVVALLWLAINIYLFIDTFCWYAEE A7E3L1_CANFA A7E3L1_CANFA --MMGC---------------------WILNESLSVILVLSWLGVNLYLFIDTFCWYEEE NOX3_HUMAN NOX3_HUMAN --MMGC---------------------WILNEGLSTILVLSWLGINFYLFIDTFYWYEEE Q4RP39_TETNG Q4RP39_TETNG ---MGN---------------------WIVNHGLTSFILVVWMGINIFLFVWFYLFYDLG A7E3K4_DANRE A7E3K4_DANRE ---MGN---------------------WIINHGLSAFIVVVWMAINIALFVHFYLFYDQG B1H1J8_DANRE B1H1J8_DANRE ----------------------------IINHGLSAFIVVVWMAINIALFVHFYLFYDQG A7E3K3_CHICK A7E3K3_CHICK ---MGN---------------------WLVNHWFSAAVLAAWLGINIFLFTYYFLFFDRD Q76I23_CAVPO Q76I23_CAVPO -------------------------------HWFSVLILVVWIGLNVFLFVQTFLKYEKS NOX1_RAT NOX1_RAT ---MGN---------------------WLVNHWLSVLFLVSWLGLNIFLFVYVFLNYEKS A2AEK5_MOUSE A2AEK5_MOUSE ---MGN---------------------WLVNHWLSVLFLVSWLGLNIFLFVYAFLNYEKS NOX1_MOUSE NOX1_MOUSE ---MGN---------------------WLVNHWLSVLFLVSWLGLNIFLFVYAFLNYEKS Q811U2_MOUSE Q811U2_MOUSE ------------------------------------------------------------ A3RF23_SHEEP A3RF23_SHEEP ------------------------------------------------------------ Q8TCT3_HUMAN Q8TCT3_HUMAN ---MGN---------------------WVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKA A6NGA6_HUMAN A6NGA6_HUMAN ---MGN---------------------WVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKA NOX1_HUMAN NOX1_HUMAN ---MGN---------------------WVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKA Q1ZYL4_HUMAN Q1ZYL4_HUMAN ---MGN---------------------WVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKA Q505H9_XENTR Q505H9_XENTR ---MGN---------------------WIVNEGLSIAVIIVWLGLNGYLFWNFYLVYDEG Q6GNG7_XENLA Q6GNG7_XENLA ---MGN---------------------WIVNEGLSIAVIIVWLALNGYLFWNFYLVYDEG A7E3K8_CHICK A7E3K8_CHICK ---MGN---------------------WVENEGLSIFVVLVWLGLNVFLFWWFYLAYDLP Q9N2H1_TURTR Q9N2H1_TURTR ---MGN---------------------LFVNEGMSIFVILVWLGMNVFLFVWYYRVYDIP CY24B_BISBI CY24B_BISBI ---MGN---------------------WVVNEGISIFVILVWLGMNVFLFVWYYRVYDIP CY24B_BOVIN CY24B_BOVIN ---MGN---------------------WVVNEGISIFVILVWLGMNVFLFVWYYRVYDIP CY24B_PIG CY24B_PIG ------------------------------------------------------------ A7E3K7_CANFA A7E3K7_CANFA ---MGN---------------------WIENEGLSIFVILVWLGLNVFLFIWFYGVYNNG B4DWE0_HUMAN B4DWE0_HUMAN ---MGN---------------------WAVNEGLSIFVI--------------------- CY24B_HUMAN CY24B_HUMAN ---MGN---------------------WAVNEGLSIFVILVWLGLNVFLFVWYYRVYDIP Q95MN3_RABIT Q95MN3_RABIT ---MGN---------------------WVENEGLSIFVIFVWLGLNVFLFVWYYWVYAFG Q8C6S5_MOUSE Q8C6S5_MOUSE ---MGD---------------------WAVNEGLSIFVILVWLGLNVFLFINYYKVYDDG Q3U4P0_MOUSE Q3U4P0_MOUSE ---MGN---------------------WAVNEGLSIFVILVWLGLNVFLFINYYKVYDDG Q3U6M7_MOUSE Q3U6M7_MOUSE ------------------------------------------------------------ Q3TVP4_MOUSE Q3TVP4_MOUSE ------------------------------------------------------------ CY24B_MOUSE CY24B_MOUSE ---MGN---------------------WAVNEGLSIFVILVWLGLNVFLFINYYKVYDDG Q3U6G0_MOUSE Q3U6G0_MOUSE ---MGN---------------------WAVNEGLSIFVILVWLGLNVFLFINYYKVYDDG Q9ER28_RAT Q9ER28_RAT ---MGN---------------------WAVNEGLSIFVILVWLGLNVFLFVKYYKVYDDE Q9ERL1_RAT Q9ERL1_RAT ---MGN---------------------WAVNEGLSIFVILVWLGLNVFLFVKYYKVYDDE A7BI57_CYPCA A7BI57_CYPCA ---MGN---------------------FAANEGLSIFVILVWLGINVFLFVHFYLAF-LV Q7T2A7_DANRE Q7T2A7_DANRE ---MGN---------------------FAANEGLSVFVILVWLGINVFLFVYFYLAF-LI Q1A3S4_SINCH Q1A3S4_SINCH ---MGN---------------------FAVNEGLSIFVILVWLGINAFLFVHFYMAF-LV Q4SEQ8_TETNG Q4SEQ8_TETNG ---MGN---------------------FAANEGLSVFVILVWLGINAFLFVHFYMAF-LV B8YQA0_SALSA B8YQA0_SALSA ---MGN---------------------FAANEGLSVFVILVWLGINAYLFVQFYMNF-LT Q60FB9_ONCMY Q60FB9_ONCMY ---MGN---------------------FAANEGLSVFVILVWLGINAYLFVQFYMNF-LT A2A237_PLEAT A2A237_PLEAT ---MGS---------------------FVANEGLSIFVILVWLGLNAFLFVHFYMAF-LT MATCH CONSENSUS ?????????????????????????????????????????????N??LF??????????

Q4SYI4_TETNG Q4SYI4_TETNG ------------------------------------------------------------ A7E3L2_CHICK A7E3L2_CHICK ----------------------------------MCRILLAFLRGS-QKVASRKTRRLID B2RSM1_MOUSE B2RSM1_MOUSE PEYYYIHQMLGLGLCLSRASASVLNLNCSLILLPMCRTVLAYLRGS-QKVPSRRTRRLLD NOX4_MOUSE NOX4_MOUSE PEYYYIHQMLGLGLCLSRASASVLNLNCSLILLPMCRTVLAYLRGS-QKVPSRRTRRLLD NOX4_RAT NOX4_RAT PEYYYIHQMLGLGLCLSRASASVLNLNCSLILLPMCRTVLAYLRGS-QKVPSRRTRRLLD NOX4_PONAB NOX4_PONAB PEYHYLHQMLGLGLCLSRASASVLNLNCSLILLPMCRTLLAYLRGS-QKVPSRRTRRLLD NOX4_HUMAN NOX4_HUMAN PEYHYLHQMLGLGLCLSRASASVLNLNCSLILLPMCRTLLAYLRGS-QKVPSRRTRRLLD B7Z520_HUMAN B7Z520_HUMAN PEYHYLHQMLGLGLCLSRASASVLNLNCSLILLPMCRTLLAYLRGS-QKVPSRRTRRLLD B3KQ17_HUMAN B3KQ17_HUMAN PEYHYLHQMLGLGLCLSRASASVLNLNCSLILLPMCRTLLAYLRGS-QKVPSRRTRRLLD B7Z523_HUMAN B7Z523_HUMAN PEYHYLHQMLGLGLCLSRASASVLNLNCSLILLPMCRTLLAYLRGS-QKVPSRRTRRLLD B7Z529_HUMAN B7Z529_HUMAN SKNLPVVSIHQLGLCLSRASASVLNLNCSLILLPMCRTLLAYLRGS-QKVPSRRTRRLLD B7Z535_HUMAN B7Z535_HUMAN ------------------------------------------------------------ A3FEK2_SHEEP A3FEK2_SHEEP ---------------------------------------------------------LLD Q6V1P7_BOVIN Q6V1P7_BOVIN PEYHYLHEMLGLGLCLSRASASVLNLNCSLILLPMCRTLLAFLRGS-QKVPSRRTRRLLD A7E3L0_CIOIN A7E3L0_CIOIN KTFFYTRVLLGPALALARAPAACLNLNCLLVLLPVCRNLLSLFRKA-CMCCPRRIRRVLD NOX3_MOUSE NOX3_MOUSE EAFFYTRVILGSALAWARASAVCLNFNCMLILLPVSRNFISLVRGT-SVCCRGPWRRQLD NOX3_RAT NOX3_RAT ESFFYTRVILGSALAWARASAVCLNFNCMLILLPVSRNFVSLVRGT-SVCCRGPWRRQLD A7E3L1_CANFA A7E3L1_CANFA ESFLYTRVILGSTLAWARASAVCLNFNCMLILLPISRNLISFMRGT-STCCRGLWRRQLD NOX3_HUMAN NOX3_HUMAN ESFHYTRVILGSTLAWARASALCLNFNCMLILIPVSRNLISFIRGT-SICCRGPWRRQLD Q4RP39_TETNG Q4RP39_TETNG DQFFYTRHLLGSALAWARAPAAVLNFNCMLILLPVCRNLLSLLRGS-FVCCGRSMRKQLD A7E3K4_DANRE A7E3K4_DANRE ERFEYTRELLGSALAWARAPAAVLNFNCMLILLPVCRNLLSLLRGS-FVCCGRTVRKQLD B1H1J8_DANRE B1H1J8_DANRE ERFEYTRELLGSALAWARAPAAVLNFNCMLILLPVCRNLLSLLRGS-FVCCGRTVRKQLD A7E3K3_CHICK A7E3K3_CHICK ERYFYTRAILGSALAWARASAKCLNFNSMLILLPVCRNLLSFLRGS-FSCCRRTLRKQLD Q76I23_CAVPO Q76I23_CAVPO DEYYYTREILGTALAVARASARCLNFNSMLILVPVCRNLLSFLRGT-CSFCNRTLRKPLD NOX1_RAT NOX1_RAT DKYYYTREILGTALALARASALCLNFNSMVILIPVCRNLLSFLRGT-CSFCNHTLRKPLD A2AEK5_MOUSE A2AEK5_MOUSE DKYYYTREILGTALALARASALCLNFNSMMILIPVCRNLLSFLRGT-CSFCNRTLRKPLD NOX1_MOUSE NOX1_MOUSE DKYYYTREILGTALALARASALCLNFNSMMILIPVCRNLLSFLRGT-CSFCNRTLRKPLD Q811U2_MOUSE Q811U2_MOUSE ----------------------------------------------------RTLRKPLD A3RF23_SHEEP A3RF23_SHEEP ------------------------------------------------------------ Q8TCT3_HUMAN Q8TCT3_HUMAN DKYYYTRKILGSTLACARASALCLNFNSTLILLPVCRNLLSFLRGT-CSFCSRTLRKQLD A6NGA6_HUMAN A6NGA6_HUMAN DKYYYTRKILG--------------------------------------FCSRTLRKQLD NOX1_HUMAN NOX1_HUMAN DKYYYTRKILGSTLACARASALCLNFNSTLILLPVCRNLLSFLRGT-CSFCSRTLRKQLD Q1ZYL4_HUMAN Q1ZYL4_HUMAN DKYYYTRKILG--------------------------------------FCSRTLRKQLD Q505H9_XENTR Q505H9_XENTR EKYFYSRKLYGSALAWARAPAACLNFNCLLILLPVCRNLLSFLRGS-SACCGRSLRRQLD Q6GNG7_XENLA Q6GNG7_XENLA EAYFYSRKLYGSALAWARAPAACLNFNCLLILLPVCRNLLSFLRGS-SACCGRSLRRQLD A7E3K8_CHICK A7E3K8_CHICK QNFFYTRVLLGRALALARAPAACLNFNCMLILLPVCRNLLSFLRGSNSKCCSTRVRRQLD Q9N2H1_TURTR Q9N2H1_TURTR DKFFYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGS-SACCSTRIRRQLD CY24B_BISBI CY24B_BISBI DKFFYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGS-SACCSTRIRRQLD CY24B_BOVIN CY24B_BOVIN DKFFYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGS-SACCSTRIRRQLD CY24B_PIG CY24B_PIG ---------------------------------------------------STRVRRQLD A7E3K7_CANFA A7E3K7_CANFA EEFFYTRKLLGFALPLARAPAACLNFNCMLILLPVCRNLLSFLRGS-SACCSTRIRRQLD B4DWE0_HUMAN B4DWE0_HUMAN -----------SALALARAPAACLNFNCMLILLPVCRNLLSFLRGS-SACCSTRVRRQLD CY24B_HUMAN CY24B_HUMAN PKFFYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGS-SACCSTRVRRQLD Q95MN3_RABIT Q95MN3_RABIT KKYYYTTKLLGAALPLARAPAACLNFNCLLILLPVCRNLLSFLRGS-SACCSTRIRRQLD Q8C6S5_MOUSE Q8C6S5_MOUSE PKYNYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGS-SACCSTRIRRQLD Q3U4P0_MOUSE Q3U4P0_MOUSE PKYNYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGS-SACCSTRIRRQLD Q3U6M7_MOUSE Q3U6M7_MOUSE ------------------------------------------------------------ Q3TVP4_MOUSE Q3TVP4_MOUSE ------------------------------------------------------------ CY24B_MOUSE CY24B_MOUSE PKYNYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGS-SACCSTRIRRQLD Q3U6G0_MOUSE Q3U6G0_MOUSE PKYNYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGS-SACCSTRIRRQLD Q9ER28_RAT Q9ER28_RAT PKYNYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGS-SACCSTRIRRQLD Q9ERL1_RAT Q9ERL1_RAT PKYNYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGS-SACCSTRIRRQLD A7BI57_CYPCA A7BI57_CYPCA ERYYYTRVILGHALSWARAPAACLNFNCMLILLPVCRNLLSFLRGS-IQYCSRTAARQLD Q7T2A7_DANRE Q7T2A7_DANRE DKYYYTRVILGHALSWARAPAACLNFNCMLILLPVCRNLLSFLRGS-IQCCSRTAARQLD Q1A3S4_SINCH Q1A3S4_SINCH ERWFYTRVLLGQALPWAKAPAACLNFNCLLILLPVCRNLLSFLRGS-IQYCSRTAARQLD Q4SEQ8_TETNG Q4SEQ8_TETNG ERWFYTRVLLGHALSWARAPAACLNFNCMLILLPVCRNLLSFLRGS-IQCCSRTAARQLD B8YQA0_SALSA B8YQA0_SALSA ERWFYTRVLIGDALSWARAPAACLNFNCMLILLPVCRNLLSFLRGS-IQCCSRTAARQLD Q60FB9_ONCMY Q60FB9_ONCMY ERWFYTRVLLGDALSWARAPAACLNFNCMLILLPVCRNLLSFLRGS-IQCCSRTAARQLD A2A237_PLEAT A2A237_PLEAT ERWFYTRVLLGDALSWARAPAACLNFNCMLILLPVCRNLLSFLRGT-IQCCSRTAARQLD MATCH CONSENSUS ????Y?????G??L????A?A??LN?N????L?P??R??????RG?????????????LD

Q4SYI4_TETNG Q4SYI4_TETNG ------------------------------------------------------------ A7E3L2_CHICK A7E3L2_CHICK KSKTFHVTCGVTVCIFS-VHVAAHLVNALNFSENYNED---------------------- B2RSM1_MOUSE B2RSM1_MOUSE KSKTLHITCGVTICIFSGVHVAAHLVNALNFSVNYSED---------------------- NOX4_MOUSE NOX4_MOUSE KSKTLHITCGVTICIFSGVHVAAHLVNALNFSVNYSED---------------------- NOX4_RAT NOX4_RAT KSKTLHITCGITICIFSGVHVAAHLVNALNFSVNYSEH---------------------- NOX4_PONAB NOX4_PONAB KSRTFHITCGVTICIFSGVHVAAHLVNALNFSVNYSED---------------------- NOX4_HUMAN NOX4_HUMAN KSRTFHITCGVTICIFSGVHVAAHLVNALNFSVNYSED---------------------- B7Z520_HUMAN B7Z520_HUMAN KSRTFHITCGVTICIFSGVHVAAHLVNALNFSVNYSED---------------------- B3KQ17_HUMAN B3KQ17_HUMAN KSRTFHITCGVAICIFSGVHVAAHLVNALNFSVNYSED---------------------- B7Z523_HUMAN B7Z523_HUMAN KSRTFHITCGVTICIFSGVHVAAHLVNALNFSVNYSED---------------------- B7Z529_HUMAN B7Z529_HUMAN KSRTFHITCGVTICIFSGVHVAAHLVNALNFSVNYSED---------------------- B7Z535_HUMAN B7Z535_HUMAN ------------------------------------------------------------ A3FEK2_SHEEP A3FEK2_SHEEP KSRTXHITCGVTICIFSGVHVAAHLVNALNFSVNYRED---------------------- Q6V1P7_BOVIN Q6V1P7_BOVIN KSRTFHITCGVTICIFSGVHVAAHLVNALNFSVNYRED---------------------- A7E3L0_CIOIN A7E3L0_CIOIN KNIKFHRMCAYMIVLMTLIHYFAHCFNVDFFTSAYQSKILATDTPAIIQQKKLIAKLIQI NOX3_MOUSE NOX3_MOUSE KNLNFHKLVAYGIAVNSVIHIVAHLFNLERYHLGQAKD-----------AEGLLAALSKL NOX3_RAT NOX3_RAT KNLKFHKLVAYGIAVNSVIHIVAHLFNLERYHLGQAKD-----------AEGLLAALSKL A7E3L1_CANFA A7E3L1_CANFA KNLKFHKLVAYGIAVNATIHIVAHLCNLQRYHWSQSAE-----------VQGLPATLSKL NOX3_HUMAN NOX3_HUMAN KNLRFHKLVAYGIAVNATIHIVAHFFNLERYHWSQSEE-----------AQGLLAALSKL Q4RP39_TETNG Q4RP39_TETNG KNLSFHKLVAYMIALMTAVHTVAHLLNVEWYNNSRQGV-----------YDELSTALSKL A7E3K4_DANRE A7E3K4_DANRE KNLTFHKLVAYMIALMTAVHTIAHLFNAERYSNSLEGE-----------DGDLAFELSLL B1H1J8_DANRE B1H1J8_DANRE KNLTFHKLVAYMIALMTAVHTIAHLFNAERYSNSLEGE-----------DGDLAFELSLL A7E3K3_CHICK A7E3K3_CHICK HNLTFHKLVAYALALLTAVHTIAHLFNLERYNHSQQAN-----------DGSLHAVLSKM Q76I23_CAVPO Q76I23_CAVPO QNLTFHKLVAYAICIFTAIHIIAHLFNFERYHTSQQAK-----------DGSLASVLSGL NOX1_RAT NOX1_RAT HNLTFHKLVAYMICIFTAIHIIAHLFNFERYSRSQQAM-----------DGSLASVLSSL A2AEK5_MOUSE A2AEK5_MOUSE HNLTFHKLVAYMICIFTVIHIIAHLFNFERYRRSQQAM-----------DGSLASVLSSL NOX1_MOUSE NOX1_MOUSE HNLTFHKLVAYMICIFTVIHIIAHLFNFERYRRSQQAM-----------DGSLASVLSSL Q811U2_MOUSE Q811U2_MOUSE HNLTFHKLVAYMICIFTVIHIIAHLFNFERYRRSQQAM-----------DGSLASVLSSL A3RF23_SHEEP A3RF23_SHEEP ------------------------------------------------------------ Q8TCT3_HUMAN Q8TCT3_HUMAN HNLTFHKLVAYMICLHTAIHIIAHLFNFDCYSRSRQAT-----------DGSLASILSSL A6NGA6_HUMAN A6NGA6_HUMAN HNLTFHKLVAYMICLHTAIHIIAHLFNFDCYSRSRQAT-----------DGSLASILSSL NOX1_HUMAN NOX1_HUMAN HNLTFHKLVAYMICLHTAIHIIAHLFNFDCYSRSRQAT-----------DGSLASILSSL Q1ZYL4_HUMAN Q1ZYL4_HUMAN HNLTFHKLVAYMICLHTAIHIIAHLFNFDCYSRSRQAT-----------DGSLASILSSL Q505H9_XENTR Q505H9_XENTR RNLTFHKMVAWMIALHTAIHTGAHLFNVERLVDARVEA-----------NGTIQAALTDL Q6GNG7_XENLA Q6GNG7_XENLA RNLTFHKMVAWMIALHTAIHTGAHLFNVERLVDARVEA-----------NGTIQAALTSL A7E3K8_CHICK A7E3K8_CHICK RNLTFHKMVAWMIALHTAIHTIAHLFNVEWSVHARVEE-----------EGTLAAVLSRL Q9N2H1_TURTR Q9N2H1_TURTR RNLTFHKMVAWMIALHTAIHTIAHLFNVEWCVNARVNN-----------SDPYSIALSDI CY24B_BISBI CY24B_BISBI RNLTFHKMVAWMIALHTAIHTIAHLFNVEWCVNARVNN-----------SDPYSIALSDI CY24B_BOVIN CY24B_BOVIN RNLTFHKMVAWMIALHTAIHTIAHLFNVEWCVNARVNN-----------SDPYSIALSDI CY24B_PIG CY24B_PIG RNLTFHKMVAWMIALHATIHTIAHLFNVEWCVNARVNN-----------SDPYSIALSDI A7E3K7_CANFA A7E3K7_CANFA RNLTFHKLVAWMIALHTAIHTIAHLFNVEWCVNARVNN-----------SDVYSIALSNL B4DWE0_HUMAN B4DWE0_HUMAN RNLTFHKMVAWMIALHSAIHTIAHLFNVEWCVNARVNN-----------SDPYSVALSEL CY24B_HUMAN CY24B_HUMAN RNLTFHKMVAWMIALHSAIHTIAHLFNVEWCVNARVNN-----------SDPYSVALSEL Q95MN3_RABIT Q95MN3_RABIT RNLTFHKMVAWMIALHSAIHTIAHLFNVEWCVNARVNN-----------SDSYSIALSEI Q8C6S5_MOUSE Q8C6S5_MOUSE RNLTFHKMVAWMIALHTAIHTIAHLFNVEWCVNARVGI-----------SDRYSIALSDI Q3U4P0_MOUSE Q3U4P0_MOUSE RNLTFHKMVAWMIALHTAIHTIAHLFNVEWCVNARVRI-----------SDRYSIALSDI Q3U6M7_MOUSE Q3U6M7_MOUSE ------------------------------------------------------------ Q3TVP4_MOUSE Q3TVP4_MOUSE ------------------------------------------------------------ CY24B_MOUSE CY24B_MOUSE RNLTFHKMVAWMIALHTAIHTIAHLFNVEWCVNARVGI-----------SDRYSIALSDI Q3U6G0_MOUSE Q3U6G0_MOUSE RNLTFHKMVAWMIALHTAIHTIAHLFNVEWCVNARVGI-----------SDRYSIALSDI Q9ER28_RAT Q9ER28_RAT RNLTFHKMVAWMIALHTAIHTIAHLFNVEWCVNARVGT-----------SDPYSVALSNI Q9ERL1_RAT Q9ERL1_RAT RNLTFHKMVAWMIALHTAIHTIAHLFNVEWCVNARVGT-----------SDPYSVALSNI A7BI57_CYPCA A7BI57_CYPCA RNLTFHKLVAYMIALHTAIHIIAHLFNFERFMDSQLMI----------NSSYLPYVLSQI Q7T2A7_DANRE Q7T2A7_DANRE RNITFHKLVAYMIAFHTAVHIIAHLFNFERFMDSQLMI----------NSSHLPYVLSQI Q1A3S4_SINCH Q1A3S4_SINCH RNLTFHKLVAYMIAFHTAVHIVAHLFNFEYFMDAQLNR----------NSSLLPFILSEI Q4SEQ8_TETNG Q4SEQ8_TETNG RNLTFHKLVAYMIAFHTAVHIVAHLFNFEFFMDAQLNR----------NSSYLPFILSEI B8YQA0_SALSA B8YQA0_SALSA RNITFHKLVAYMIAFHTAVHIIAHLFNFEWFMGAQLYR----------NSSSLPFVLSQI Q60FB9_ONCMY Q60FB9_ONCMY RNITFHKLVAYMIAFHTAVHIIAHLFNFEWFMGAQLYR----------NSSSLPFVLSQI A2A237_PLEAT A2A237_PLEAT RNLTFHKLVAYMIAFHTAVHIVAHLFNFEWFMDAQLLG----------NSSQLPFVLSQI MATCH CONSENSUS ???TFH??????I??????H??AHL?N?????????????????????????????????

Q4SYI4_TETNG Q4SYI4_TETNG ------------------------------------------------------------ A7E3L2_CHICK A7E3L2_CHICK -------FLAINAANYRGEDPR----KLLFATVPGLTGVIMVLVLFLMCTASTYAIRVSN B2RSM1_MOUSE B2RSM1_MOUSE -------FLELNAARYQNEDPR----KLLFTTIPGLTGVCMVVVLFLMVTASTYAIRVSN NOX4_MOUSE NOX4_MOUSE -------FLELNAARYQNEDPR----KLLFTTIPGLTGVCMVVVLFLMVTASTYAIRVSN NOX4_RAT NOX4_RAT -------FLALNAARYQNEDPR----KLLFTTVPGLTGVCMVVVLFLMVTASTYAIRVSN NOX4_PONAB NOX4_PONAB -------FVELNAARYRDEDPR----KLLFTTVPGLTGVCMVVVLFLMITASTYAIRVSN NOX4_HUMAN NOX4_HUMAN -------FVELNAARYRDEDPR----KLLFTTVPGLTGVCMVVVLFLMITASTYAIRVSN B7Z520_HUMAN B7Z520_HUMAN -------FVELNAARYRDEDPR----KLLFTTVPGLTGVCMVVVLFLMITASTYAIRVSN B3KQ17_HUMAN B3KQ17_HUMAN -------FVELNAARYRDEDPR----KLLFTTVPGLTGVCMVVVLFLMITASTYAIRVSN B7Z523_HUMAN B7Z523_HUMAN -------FVELNAARYRDEDPR----KLLFTTVPGLTGVCMVVVLFLMITASTYAIRVSN B7Z529_HUMAN B7Z529_HUMAN -------FVELNAARYRDEDPR----KLLFTTVPGLTGVCMVVVLFLMITASTYAIRVSN B7Z535_HUMAN B7Z535_HUMAN ----------------------------------------MVVVLFLMITASTYAIRVSN A3FEK2_SHEEP A3FEK2_SHEEP -------FVELNAARYREEDPR----KLLFTTVPGLTGVCMVLVLFLMITASTYAIRVSN Q6V1P7_BOVIN Q6V1P7_BOVIN -------FVELNAARYREEDPR----KLLFTTVPGLTGVCMVLVLFLMFTASTYAIRVSN A7E3L0_CIOIN A7E3L0_CIOIN GNNGN--ETYLNPIRKSVFSVG-----AVFLLTGGWTGVIITLSLFFMVTSSLEFIRRSY NOX3_MOUSE NOX3_MOUSE GDAPN--ESYLNPVRTFDMGTT----TELLMTVSGITGLGISLALVFIMTSSTEFIRRSS NOX3_RAT NOX3_RAT GNAPN--ESYLNPVRTLYTGTT----TQLLMTVSGITGLVISLALILIMTSSTEFIRQSS A7E3L1_CANFA A7E3L1_CANFA GNAPN--ESYLNPIRTFHTNTI----TELLTTIAGVTGLIISLALVLIMTSSTESIRQVS NOX3_HUMAN NOX3_HUMAN GNTPN--ESYLNPVRTFPTNTT----TELLRTIAGVTGLVISLALVLIMTSSTEFIRQAS Q4RP39_TETNG Q4RP39_TETNG DDANG--TTYLNPIRITDLIPT----YFAFTTIAGLTGVIITLSLILIITSSMEVIRRSY A7E3K4_DANRE A7E3K4_DANRE QDSSELNTTYLNPFPSNSTTPM----IFVFTSIAGLTGVVITLALILMITSSMEVIRRSY B1H1J8_DANRE B1H1J8_DANRE QDSSELNTTYLNPFPSNSTTPM----IFVFTSIAGLTGVVITLALILMITSSMEVIRRSY A7E3K3_CHICK A7E3K3_CHICK HLQDS--NKWLNPIHSNQTPPLQTVEYVAFTTIPGLTGVIITLALILMVTSSTEFIRRNY Q76I23_CAVPO Q76I23_CAVPO SHHEKYGGSWLNPFQSPNMTVL----YVTFTSIAGLTGEIGTVALILMVTSAMEFIRRHY NOX1_RAT NOX1_RAT FHPEKE-DSWLNPIQSPNVTVM----YAAFTSIAGLTGVVATVALVLMVTSAMEFIRRNY A2AEK5_MOUSE A2AEK5_MOUSE SHPEKE-DSWLNPIQSPNMTVM----YAAFTSIAGLTGVIATVALVLMVTSAMEFIRRNY NOX1_MOUSE NOX1_MOUSE SHPEKE-DSWLNPIQSPNMTVM----YAAFTSIAGLTGVIATVALVLMVTSAMEFIRRNY Q811U2_MOUSE Q811U2_MOUSE SHPEKE-DSWLNPIQSPNMTVM----YAAFTSIAGLTGVIATVALVLMVTSAMEFIRRNY A3RF23_SHEEP A3RF23_SHEEP ------------------------------------------------------------ Q8TCT3_HUMAN Q8TCT3_HUMAN SHDEKKGGSWLNPIQSRNTTVE----YVTFTSIAGLTGVIMTIALILMVTSATEFIRRSY A6NGA6_HUMAN A6NGA6_HUMAN SHDEKKGGSWLNPIQSRNTTVE----YVTFTSIAGLTGVIMTIALILMVTSATEFIRRSY NOX1_HUMAN NOX1_HUMAN SHDEKKGGSWLNPIQSRNTTVE----YVTFTSIAGLTGVIMTIALILMVTSATEFIRRSY Q1ZYL4_HUMAN Q1ZYL4_HUMAN SHDEKKGGSWLNPIQSRNTTVE----YVTFTSIAGLTGVIMTIALILMVTSATEFIRRSY Q505H9_XENTR Q505H9_XENTR GDREG--ESYLNFVRSRVPNPIGGI-NVAFTFLAGLTGVVITLALILIITSSTKTIRRSY Q6GNG7_XENLA Q6GNG7_XENLA GDRDG--ESYLNFVRSRVPNPIGGI-NVAFTFLAGLTGVVITLALILIITSSTKTIRRSY A7E3K8_CHICK A7E3K8_CHICK GDSPN--ESYINFYRQTIPNPVGGL-YVAFTYLAGLTGVIITLALILIITSSTKIIRRSY Q9N2H1_TURTR Q9N2H1_TURTR GDKPG--ETYLNFARQRIKNPEGGL-YVAVTRLAGITGVVITLCLILIITSSTKTIRRSY CY24B_BISBI CY24B_BISBI GDKPN--ETYLNFVRQRIKNPEGGL-YVAVTLLAGITGVVITLCLILIITSSTKTIRRSY CY24B_BOVIN CY24B_BOVIN GDKPN--ETYLNFVRQRIKNPEGGL-YVAVTRLAGITGVVITLCLILIITSSTKTIRRSY CY24B_PIG CY24B_PIG GDKPN--ETYLNFVRQRIKNPEGGL-YVAVTRLAGITGVVITLCLILIITSSTKTIRRSY A7E3K7_CANFA A7E3K7_CANFA GDNPG--ESYLNFARRRIKNPEGGL-YVAVTLLAGITGIVITLCLILIITSSTKTIRRSY B4DWE0_HUMAN B4DWE0_HUMAN GDRQN--ESYLNFARKRIKNPEGGL-YLAVTLLAGITGVVITLCLILIITSSTKTIRRSY CY24B_HUMAN CY24B_HUMAN GDRQN--ESYLNFARKRIKNPEGGL-YLAVTLLAGITGVVITLCLILIITSSTKTIRRSY Q95MN3_RABIT Q95MN3_RABIT GDKKN--ETYLNFVRERIKNPEGGL-LVAVTRLAGVTGIIITLCLILIITSSTKIIRRSY Q8C6S5_MOUSE Q8C6S5_MOUSE GDNEN--EEYLNFAREKIKNPEGGL-YVAVTRLAGITGIVITLCLILIITSSTKTIRRSY Q3U4P0_MOUSE Q3U4P0_MOUSE GDNEN--EEYLNFAREKIKNPEGGL-YVAVTRLAGITGIVITLCLILIITSSTKTIRRSY Q3U6M7_MOUSE Q3U6M7_MOUSE ------------------------------------------------------------ Q3TVP4_MOUSE Q3TVP4_MOUSE ----------------------------------GITGIVITLCLILIITSSTKTIRRSY CY24B_MOUSE CY24B_MOUSE GDNEN--EEYLNFAREKIKNPEGGL-YVAVTRLAGITGIVITLCLILIITSSTKTIRRSY Q3U6G0_MOUSE Q3U6G0_MOUSE GDNEN--EEYLNFAREKIKNPEGGL-YVAVTRLAGITGIVITLCLILIITSSTKTIRRSY Q9ER28_RAT Q9ER28_RAT GDKEN--EEYLNFAREKIKNPEGGL-YVAVTRLAGITGIVITLCLILIITSSTKTIRRSY Q9ERL1_RAT Q9ERL1_RAT GDKEN--EEYLNFAREKIKNPEGGL-YVAVTRLAGITGIVITLCLILIITSSTKTIRRSY A7BI57_CYPCA A7BI57_CYPCA GNNDN--RSYLNPIRTNETNPT----IVMFTTIAGLTGVVITLALILIITSSMEVIRRSY Q7T2A7_DANRE Q7T2A7_DANRE GNNDN--RSYLNPIRSNDTNPT----IVMFTTVAGLTGVVITLALILIITSSMEVIRRSY Q1A3S4_SINCH Q1A3S4_SINCH GTGDN--AAFLNPIRTNETNPT----IVMFTTIAGVTGVVITLALILIVTSSMEVIRRSY Q4SEQ8_TETNG Q4SEQ8_TETNG GTGDN--ASFLNPIRTNETNPT----IVMFTTIAGLTGVAITLALILIITSSMEVIRRSY B8YQA0_SALSA B8YQA0_SALSA GTGDN--ASYLNPIRTDQTNPT----IVMFTTIAGLTGVVITLALILIITSSMEVIRRSY Q60FB9_ONCMY Q60FB9_ONCMY GTGDN--ASYLNPIRTDQTNPT----IVMFTTIAGLTGVVITLALILIITSSMEVIRRSY A2A237_PLEAT A2A237_PLEAT GNGDN--ASFLNPIRSNETNPT----IVMFTTIAGLTGVAITLALILIITSSMEVIRRSY MATCH CONSENSUS ??????????LN??????????????????T???G?TG??????L?L??T?????IR?S?

Q4SYI4_TETNG Q4SYI4_TETNG ------------------------------------------------------------ A7E3L2_CHICK A7E3L2_CHICK YDIFWYTHNLFFVFYILLMLHVSGGVLKYQTNLEEHPPGCFNPNKTLLGNMTVPKSFEEL B2RSM1_MOUSE B2RSM1_MOUSE YDIFWYTHNLFFVFYMLLLLHVSGGLLKYQTNVDTHPPGCISLNQ--------TSSQNMS NOX4_MOUSE NOX4_MOUSE YDIFWYTHNLFFVFYMLLLLHVSGGLLKYQTNVDTHPPGCISLNQ--------TSSQNMS NOX4_RAT NOX4_RAT YDIFWYTHNLFFVFYMLLLLHVSGGLLKYQTNLDTHPPGCISLNR--------TPSQNMS NOX4_PONAB NOX4_PONAB YDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNR--------TSSQNIS NOX4_HUMAN NOX4_HUMAN YDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNR--------TSSQNIS B7Z520_HUMAN B7Z520_HUMAN YDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNR--------TSSQNIS B3KQ17_HUMAN B3KQ17_HUMAN YDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNR--------TSSQNIS B7Z523_HUMAN B7Z523_HUMAN YDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNR--------TSSQNIS B7Z529_HUMAN B7Z529_HUMAN YDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNR--------TSSQNIS B7Z535_HUMAN B7Z535_HUMAN YDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNR--------TSSQNIS A3FEK2_SHEEP A3FEK2_SHEEP YDIFWYTHNLFFVFYMLLMLHVSGGLLKYQTNLDTHPPGCINLNG--------THFQNTH Q6V1P7_BOVIN Q6V1P7_BOVIN YDIFWYTHNLFFVFYMLLMLHVSGGLLKYQTNLDTHPPGCINLNG--------THYQNTH A7E3L0_CIOIN A7E3L0_CIOIN FEVFWFTHHLFIVFYGFLVVHGISMQVRGQT----------------------PQSLTVH NOX3_MOUSE NOX3_MOUSE YELFWYTHHIFVFFFISLAIHGGGRIIRGQT----------------------PESLRLH NOX3_RAT NOX3_RAT YELFWYTHHIFIFLFISLAIHGGGRIIRGQT----------------------PESLRLH A7E3L1_CANFA A7E3L1_CANFA YELFWYTHHVFIIFFIGLAIHGAGRIVRGQT----------------------PESQLLH NOX3_HUMAN NOX3_HUMAN YELFWYTHHVFIVFFLSLAIHGTGRIVRGQT----------------------QDSLSLH Q4RP39_TETNG Q4RP39_TETNG FEVFWYTHHLFIIFFAGLVFHGAGRIVRSQ-----------------------QTTNPPH A7E3K4_DANRE A7E3K4_DANRE FEVFWYTHHLFIVFFAGLVFHGAGRVVRGQV-----------------------TTDPPH B1H1J8_DANRE B1H1J8_DANRE FEVFWYTHHLFIVFFAGLVFHGAGRVVRGQV-----------------------TTDPPH A7E3K3_CHICK A7E3K3_CHICK FEVFWYTHHLFIIYFIGLVIHGVAGLVRGQT----------------------EESMKEV Q76I23_CAVPO Q76I23_CAVPO FELFWFTHHLFIVYFLCLALHGFGRIVRGQT----------------------KDSMKES NOX1_RAT NOX1_RAT FELFWYTHHLFIIYIICLGIHGLGGIVRGQT----------------------EESMSES A2AEK5_MOUSE A2AEK5_MOUSE FELFWYTHHLFIVYIICLGIHGLGGIVRGQT----------------------EESLGES NOX1_MOUSE NOX1_MOUSE FELFWYTHHLFIVYIICLGIHGLGGIVRGQT----------------------EESLGES Q811U2_MOUSE Q811U2_MOUSE FELFWYTHHLFIVYIICLGIHGLGGIVRGQT----------------------EESLGES A3RF23_SHEEP A3RF23_SHEEP ------------------------------------------------------------ Q8TCT3_HUMAN Q8TCT3_HUMAN FEVFWYTHHLFIFYILGLGIHGIGGIVRGQT----------------------EESMNES A6NGA6_HUMAN A6NGA6_HUMAN FEVFWYTHHLFIFYILGLGIHGIGGIVRGQT----------------------EESMNES NOX1_HUMAN NOX1_HUMAN FEVFWYTHHLFIFYILGLGIHGIGGIVRGQT----------------------EESMNES Q1ZYL4_HUMAN Q1ZYL4_HUMAN FEVFWYTHHLFIFYILGLGIHGIGGIVRGQT----------------------EESMNES Q505H9_XENTR Q505H9_XENTR FEVFWYTHHLFVIFFIGLVIHGAGKIVRGQT----------------------DKSLEKH Q6GNG7_XENLA Q6GNG7_XENLA FEVFWYTHHLFVVFFIGLVIHGVGRIVRGQT----------------------AASREKH A7E3K8_CHICK A7E3K8_CHICK FEVFWYTHHLFVIFFIGLVIHGAGRIVRGQT----------------------AVSLAEH Q9N2H1_TURTR Q9N2H1_TURTR FEVFWYTHHLFVIFFIGLAIHGAERIVRGQT----------------------AESLLKH CY24B_BISBI CY24B_BISBI FEVFWYTHHLFVIFFIGLAIHGAQRIVRGQT----------------------AESLLKH CY24B_BOVIN CY24B_BOVIN FEVFWYTHHLFVIFFIGLAIHGAQRIVRGQT----------------------AESLLKH CY24B_PIG CY24B_PIG FEVFWYTHHLFVIFFIGLAIHGAERIVRRQT----------------------PKSLLVH A7E3K7_CANFA A7E3K7_CANFA FEVFWYTHHLFVIFFIGLAIHGAERIVRGQT----------------------AASRLEH B4DWE0_HUMAN B4DWE0_HUMAN FEVFWYTHHLFVIFFIGLAIHGAERIVRGQT----------------------AESLAVH CY24B_HUMAN CY24B_HUMAN FEVFWYTHHLFVIFFIGLAIHGAERIVRGQT----------------------AESLAVH Q95MN3_RABIT Q95MN3_RABIT FEVFWYTHHLFVIFFIGLAIHGAERIVRGQT----------------------EESLKKH Q8C6S5_MOUSE Q8C6S5_MOUSE FEVFWYTHHLFVIFFIGLAIHGAERIVRGQT----------------------AESLEEH Q3U4P0_MOUSE Q3U4P0_MOUSE FEVFWYTHHLFVIFFIGLAIHGAERIVRGQT----------------------AESLEEH Q3U6M7_MOUSE Q3U6M7_MOUSE ------------------------------------------------------------ Q3TVP4_MOUSE Q3TVP4_MOUSE FEVFWYTHHLFVIFFIGLAIHGAERIVRGQT----------------------AESLEEH CY24B_MOUSE CY24B_MOUSE FEVFWYTHHLFVIFFIGLAIHGAERIVRGQT----------------------AESLEEH Q3U6G0_MOUSE Q3U6G0_MOUSE FEVFWYTHHLFVIFFIGLAIHGAERIVRGQT----------------------AESLEEH Q9ER28_RAT Q9ER28_RAT FEVFWYTHHLFVIFFIGLAIHGAERIVRGQT----------------------SDSLKEH Q9ERL1_RAT Q9ERL1_RAT FEVFWYTHHLFVIFFIGLAIHGAERIVRGQT----------------------SDSLKEH A7BI57_CYPCA A7BI57_CYPCA FEVFWFTHHLFIVFFIGLVLHGVGRIVRGQT----------------------IESVKVH Q7T2A7_DANRE Q7T2A7_DANRE FEVFWFTHHLFIVFFIGLVLHGIGRIVRGQT----------------------DADLQVH Q1A3S4_SINCH Q1A3S4_SINCH FEVFWYTHHLFVIFFIGLVFHGYGRIVRGQT----------------------LASLRTN Q4SEQ8_TETNG Q4SEQ8_TETNG FEVFWYTHHLFVIFFIGLVLHGFGRIVRGQT----------------------AASLKTN B8YQA0_SALSA B8YQA0_SALSA FEVFWYTHHLFIIFFIGLVFHGFGRIVRGQT----------------------ATSLLEN Q60FB9_ONCMY Q60FB9_ONCMY FEVFWYTHHLFIIFFIGLVFHGFGRIVRGQT----------------------ATSLLEN A2A237_PLEAT A2A237_PLEAT FEVFWYTHHLFVIFFIGLVFHGFGRIVRGQT----------------------ASSLDEH MATCH CONSENSUS ???FWYTH?LF??????L??H????????QT????????????????????????S????

Q4SYI4_TETNG Q4SYI4_TETNG ------Q----------------------------------------------------- A7E3L2_CHICK A7E3L2_CHICK FPDYTTE-PF----PEDLTFPQPLVQSNFMRICSKEPKFQSHFPETWFWISGPLCLYCVE B2RSM1_MOUSE B2RSM1_MOUSE IPDYVSE-HFHGSLPRGFSKLEDRYQKTLVKICLEEPKFQAHFPQTWIWISGPLCLYCAE NOX4_MOUSE NOX4_MOUSE IPDYVSE-HFHGSLPRGFSKLEDRYQKTLVKICLEEPKFQAHFPQTWIWISGPLCLYCAE NOX4_RAT NOX4_RAT IADYVSE-HFHGSLPGGFSKLEDHYQKTLVKICLEEPKFQAHFPQTWIWISGPLCLYCAE NOX4_PONAB NOX4_PONAB LPEYFSE-HFHEPFPEGFSKPEEFTQNTFVKICMEEPRFQANFPQTWLWISGPLCLYCAE NOX4_HUMAN NOX4_HUMAN LPEYFSE-HFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAE B7Z520_HUMAN B7Z520_HUMAN LPEYFSE-HFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLCISGPLCLYCAE B3KQ17_HUMAN B3KQ17_HUMAN LPEYFSE-HFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAE B7Z523_HUMAN B7Z523_HUMAN LPEYFSE-HFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAE B7Z529_HUMAN B7Z529_HUMAN LPEYFSE-HFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAE B7Z535_HUMAN B7Z535_HUMAN LPEYFSE-HFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAE A3FEK2_SHEEP A3FEK2_SHEEP LPEHLSD-HFHESFPGGFSKPDELTQNTFVKICMEEPRFQANFPQTWLWISGPLCLYCAE Q6V1P7_BOVIN Q6V1P7_BOVIN LPEHLSE-HFHESFPGGFSKPDELTQNTFVKICMEEPRFQANFPQTWLWISGPLCLYCAE A7E3L0_CIOIN A7E3L0_CIOIN DPIRCSTIDP--------------ATWSQN--NCPTPVFAGSPPMTWKWVIAPMVLYVIE NOX3_MOUSE NOX3_MOUSE NVTYCRD-HY--------------AEWQAAA-LCPVPQFSGKEPSAWKWALGPVVLYACE NOX3_RAT NOX3_RAT NVTFCRD-HF--------------DEWQEAA-SCPVPQFSGKEPSAWKWTLGPVVLYACE A7E3L1_CANFA A7E3L1_CANFA NVTFCRD-HH--------------AQWQKMA-QCPMPQFSGKEPSAWKWVLGPVVLYACE NOX3_HUMAN NOX3_HUMAN NITFCRD-RY--------------AEWQTVA-QCPVPQFSGKEPSAWKWILGPVVLYACE Q4RP39_TETNG Q4RP39_TETNG NTSYCKD-HP--------------DDWGHIP-ECPIPQFAGGFPQTWMWVIAPMFLYVCE A7E3K4_DANRE A7E3K4_DANRE NNSFCED-QP--------------DNWGKIP-ECPIPQFAGGSPQTWMYVIGPMIIYICE B1H1J8_DANRE B1H1J8_DANRE NNSFCED-QP--------------DNWGKIP-ECPIPQFAGGSPQTWMYVIGPMIIYICE A7E3K3_CHICK A7E3K3_CHICK HPQSCAE-FLVN------------KSKECRHQCCKEPEFGSIPAE-----VGMGVGLQES Q76I23_CAVPO Q76I23_CAVPO HPHKCAQ-SF--------------EKWDHHDSHCRPPQFEGNPPESWKWIVAPVILYIFE NOX1_RAT NOX1_RAT HPRNCSY-SF--------------HEWDKYERSCRSPHFVGQPPESWKWILAPIAFYIFE A2AEK5_MOUSE A2AEK5_MOUSE HPHNCSH-SF--------------HEWDDHKGSCRHPHFAGHPPESWKWILAPIAFYIFE NOX1_MOUSE NOX1_MOUSE HPHNCSH-SF--------------HEWDDHKGSCRHPHFAGHPPESWKWILAPIAFYIFE Q811U2_MOUSE Q811U2_MOUSE HPHNCSH-SF--------------HEWDDHKGSCRHPHFAGHPPESWKWILAPIAFYIFE A3RF23_SHEEP A3RF23_SHEEP ------------------------------------------------------------ Q8TCT3_HUMAN Q8TCT3_HUMAN HPRKCAE-SF--------------EMWDDRDSHCRRPKFEGHPPESWKWILASVILYICE A6NGA6_HUMAN A6NGA6_HUMAN HPRKCAE-SF--------------EMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICE NOX1_HUMAN NOX1_HUMAN HPRKCAE-SF--------------EMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICE Q1ZYL4_HUMAN Q1ZYL4_HUMAN HPRKCAE-SF--------------EMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICE Q505H9_XENTR Q505H9_XENTR NSTECED-KF--------------TEWGNIT-SCPIPQFAGNEPMTWKWVVAPMVLYVFE Q6GNG7_XENLA Q6GNG7_XENLA NPRDCEY-NF--------------TEWGNNT-SCPIPQFAGNPPGTWQWVIAPMVLYVFE A7E3K8_CHICK A7E3K8_CHICK IPEVCSK-NF--------------TDWGKKG-ACPVPQFAGNPPMTWKWVVGPMFLYFCE Q9N2H1_TURTR Q9N2H1_TURTR KPRECYQ-NI--------------SQWGKIK-DCPIPEFSGNPPMTWKWIVGPMFLYLCE CY24B_BISBI CY24B_BISBI QPRNCYQ-NI--------------SQWGKIK-DCPIPEFSGNPPMTWKWIVGPMFLYLCE CY24B_BOVIN CY24B_BOVIN QPRNCYQ-NI--------------SQWGKIE-NCPIPEFSGNPPMTWKWIVGPMFLYLCE CY24B_PIG CY24B_PIG DPKACAQ-NI--------------SQWGKIK-DCPIPEFAGNPPMTWKWIVGPMFLYLCE A7E3K7_CANFA A7E3K7_CANFA NYKVCAD-NI--------------SQWGKIP-DCPIPQFSGNPPMTWKWIVGPMFLYLCE B4DWE0_HUMAN B4DWE0_HUMAN NITVCEQ-KI--------------SEWGKIK-ECPIPQFAGNPPMTWKWIVGPMFLYLCE CY24B_HUMAN CY24B_HUMAN NITVCEQ-KI--------------SEWGKIK-ECPIPQFAGNPPMTWKWIVGPMFLYLCE Q95MN3_RABIT Q95MN3_RABIT DPVMCEQ-HI--------------SDWGKIK-DCPVPEFSGNPPMTWKWIVGPMFLYLCE Q8C6S5_MOUSE Q8C6S5_MOUSE NLDICAD-KI--------------EEWGKIK-ECPVPKFAGNPPMTWKWIVGPMFLYLCE Q3U4P0_MOUSE Q3U4P0_MOUSE NLDICAD-KI--------------EEWGKIK-ECPVPKFAGNPPMTWKWIVGPMFLYLCE Q3U6M7_MOUSE Q3U6M7_MOUSE -------------------------------------------------LVGPMFLYLCE Q3TVP4_MOUSE Q3TVP4_MOUSE NLDICAD-KI--------------EEWGKIK-ECPVPKFAGNPPMTWKWIVGPMFLYLCE CY24B_MOUSE CY24B_MOUSE NLDICAD-KI--------------EEWGKIK-ECPVPKFAGNPPMTWKWIVGPMFLYLCE Q3U6G0_MOUSE Q3U6G0_MOUSE NLDICAD-KI--------------EEWGKIK-ECPVPKFAGNPPMTWKWIVGPMFLYLCE Q9ER28_RAT Q9ER28_RAT NLDVCAD-KI--------------KEWGKIK-ECPVPKFAGNPPMTWKWIVGPMFLYLCE Q9ERL1_RAT Q9ERL1_RAT NLDVCAD-KI--------------KEWGKIK-ECPVPKFAGNPPMTWKWIVGPMFLYLCE A7BI57_CYPCA A7BI57_CYPCA KPDECHS-RF--------------EDWGKNGTDCPEPVFAGNPPMTWKWVVGPMILYVCE Q7T2A7_DANRE Q7T2A7_DANRE DPTICHS-KF--------------EKWGQNVTDCPVPIFAGNPPKTWKWVVGPMFLYVCE Q1A3S4_SINCH Q1A3S4_SINCH NPEVCAN-QF--------------EDWGNNGSDCAVPEFAGNPPMTWKWVVAPMILYVCE Q4SEQ8_TETNG Q4SEQ8_TETNG KPEVCAD-RF--------------EEWGRNGSDCAVPEFAGNPPMTWKWVVGPMILYVCE B8YQA0_SALSA B8YQA0_SALSA KPSQCAD-QF--------------ESWGKNGTFCPKPEFAGNPPMTWKWVVGPMILYVCE Q60FB9_ONCMY Q60FB9_ONCMY KPSQCAD-QF--------------ESWGKNGTFCPKPEFAGNPPMTWKWVVGPMILYVCE A2A237_PLEAT A2A237_PLEAT RPLQCKD-QF--------------ENWGQNGTNCPQPRFAGNPPMTWKWVVGPMILYVCE MATCH CONSENSUS ????????????????????????????????????P?F????P??W?W???P??LY??E

Q4SYI4_TETNG Q4SYI4_TETNG ------------------------------------------------------------ A7E3L2_CHICK A7E3L2_CHICK RLYRYIRSNKPVTITSVISHPSNVLEVRMIKDDFRARPGQYVILHCPRVSGLESHPFTLT B2RSM1_MOUSE B2RSM1_MOUSE RLYRCIRSNKPVTIISVINHPSDVMELRMIKENFKARPGQYIILHCPSVSALENHPFTLT NOX4_MOUSE NOX4_MOUSE RLYRCIRSNKPVTIISVINHPSDVMELRMIKENFKARPGQYIILHCPSVSALENHPFTLT NOX4_RAT NOX4_RAT RLYRCIRSNKPVTIISVINHPSDVMELRMIKENFKARPGQYIILHCPSVSALENHPFTLT NOX4_PONAB NOX4_PONAB RLYRYIRSNKPVTIISVISHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLT NOX4_HUMAN NOX4_HUMAN RLYRYIRSNKPVTIISVMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLT B7Z520_HUMAN B7Z520_HUMAN RLYRYIRSNKPVTIISVISHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLT B3KQ17_HUMAN B3KQ17_HUMAN RLYRYIRSNKPVTIISVISHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLT B7Z523_HUMAN B7Z523_HUMAN RLYRYIRSNKPVTIISVISHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLT B7Z529_HUMAN B7Z529_HUMAN RLYRYIRSNKPVTIISVISHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLT B7Z535_HUMAN B7Z535_HUMAN RLYRYIRSNKPVTIISVISHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLT A3FEK2_SHEEP A3FEK2_SHEEP RLYRCIRSNKPVTIISVTSHPSDVMEIRMVKENFKARPGQYIILHCPSVSALENHPFTLT Q6V1P7_BOVIN Q6V1P7_BOVIN RLYRCIRSNKPVTIISVTSHPSDVVEIRMVKENFKARPGQYIILHCPSVSALENHPFTLT A7E3L0_CIOIN A7E3L0_CIOIN RIIRLVRFNQQVEVLKVIKHPSRVLEIQMRKNGFFAEVGQYVFIMCPQLSQLEWHPFTLT NOX3_MOUSE NOX3_MOUSE RIIRFWRSHQEVVITKVVSHPSAVLELHMKKRDFKMAPGQYIFIQCPSVSPLEWHPFTLT NOX3_RAT NOX3_RAT IIIRFWRSHQEVVITKVVSHPSAVLELHMKKRDFKMAPGQYIFIQCPSISPLEWHPFTLT A7E3L1_CANFA A7E3L1_CANFA RIIRFWRFQQEVVITKVVSHPSGVLELHMKKRNFKMAPGQYILVQCPSISWLEWHPFTLT NOX3_HUMAN NOX3_HUMAN RIIRFWRFQQEVVITKVVSHPSGVLELHMKKRGFKMAPGQYILVQCPAISSLEWHPFTLT Q4RP39_TETNG Q4RP39_TETNG RLIRFVRYMQTVRYRRIVMRPSKVLELQLVKSGFKMEVGQYVFLNCPAISQLEWHPFTMT A7E3K4_DANRE A7E3K4_DANRE RLLRFIRYMQPVTYRKIVIRPSKVLELQLVKPGFSMDVGQYVFLNCPAISQLEWHPFTLT B1H1J8_DANRE B1H1J8_DANRE RLLRFIRYMQPVTYRKIVIRPSKVLELQLVKPGFSMDVGQYVFLNCPAISQLEWHPFTLT A7E3K3_CHICK A7E3K3_CHICK RLLH--TPLGGVDGLGVVMHPAKVLELQMQKKGFRMEVGQYIFVNCPAVSLLEWHPFTLT Q76I23_CAVPO Q76I23_CAVPO RILRLLRSQQRVMITEVVMHPSKVLELQMTKQGFSMEVGQYILVKCPSISLLEWHPFTLT NOX1_RAT NOX1_RAT RILRFYRSRQKVVITKVVMHPCKVLELQMRKRGFTMGIGQYIFVNCPSISFLEWHPFTLT A2AEK5_MOUSE A2AEK5_MOUSE RILRFYRSQQKVVITKVVMHPSNVLELQMRKRGFSMEVGQYIFVNCPSISFLEWHPFTLT NOX1_MOUSE NOX1_MOUSE RILRFYRSQQKVVITKVVMHPSNVLELQMRKRGFSMEVGQYIFVNCPSISFLEWHPFTLT Q811U2_MOUSE Q811U2_MOUSE RILRFYRSQQKVVITKVVMHPSNVLELQMRKRGFSMEVGQYIFVNCPSISFLEWHPFTLT A3RF23_SHEEP A3RF23_SHEEP -----------VVITKVVMHPSKVLELQMHKHGFSMEVGQYIFVNCPSISSLERHPFTLT Q8TCT3_HUMAN Q8TCT3_HUMAN RILRFYRSQQKVVITKVVMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLT A6NGA6_HUMAN A6NGA6_HUMAN RILRFYRSQQKVVITKVVMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLT NOX1_HUMAN NOX1_HUMAN RILRFYRSQQKVVITKVVMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLT Q1ZYL4_HUMAN Q1ZYL4_HUMAN RILRFYRSQQKVVITKVVMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLA Q505H9_XENTR Q505H9_XENTR RLVRFWRSQQKVVITKVVTHPFKTIELQMKMKGFKMEVGQYIFVQCPAVSKLEWHPFTLT Q6GNG7_XENLA Q6GNG7_XENLA RLVRFWRSQQKVVITKVVTHPFKTIELQMKMKGFKMEVGQYISVQCPAVSRLEWHPFTLT A7E3K8_CHICK A7E3K8_CHICK RLVRFWRSQQKVVITKVVIHPFKTIELQMMKKGFKMEVGQYIFVKCPAVSKLEWHPFTLT Q9N2H1_TURTR Q9N2H1_TURTR RLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPVVSRLEWHPFTLT CY24B_BISBI CY24B_BISBI RLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPVVSKLEWHPFTLT CY24B_BOVIN CY24B_BOVIN RLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPVVSKLEWHPFTLT CY24B_PIG CY24B_PIG RLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFRMEVGQYIFVKRPAVSKLEWHPFTLT A7E3K7_CANFA A7E3K7_CANFA RLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSSLEWHPFTLT B4DWE0_HUMAN B4DWE0_HUMAN RLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHPFTLT CY24B_HUMAN CY24B_HUMAN RLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHPFTLT Q95MN3_RABIT Q95MN3_RABIT RLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPTVSKLEWHPFTLT Q8C6S5_MOUSE Q8C6S5_MOUSE RLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHTFTLT Q3U4P0_MOUSE Q3U4P0_MOUSE RLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHPFTLT Q3U6M7_MOUSE Q3U6M7_MOUSE RLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHPFTLT Q3TVP4_MOUSE Q3TVP4_MOUSE RLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSNLEWHPFTLT CY24B_MOUSE CY24B_MOUSE RLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHPFTLT Q3U6G0_MOUSE Q3U6G0_MOUSE RLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHPFTLT Q9ER28_RAT Q9ER28_RAT RLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFRMEVGQYIFVKRPAVSKLEWHPFTLT Q9ERL1_RAT Q9ERL1_RAT RLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPQVSKLEWHPFTLT A7BI57_CYPCA A7BI57_CYPCA RLVRFYRSQQKVVITKVVMHPSKTLELQMKKKGFKMEVGQYVFIKCPSISQLEWHPFTLT Q7T2A7_DANRE Q7T2A7_DANRE RLVRFYRSQQKVVITKVVTHPSKTLELQMKKKGFKMEVGQYIFMMCPSISQLEWHPFTLT Q1A3S4_SINCH Q1A3S4_SINCH RLVRIYRSHQKVVITKVVMHPSKTLELQMKRKGFHMEVGQYVFIQCPSVSRLEWHPFTLT Q4SEQ8_TETNG Q4SEQ8_TETNG RIVRFYRSHQKVVITKVVMHPSKTLELRMKRKGFHMEVGQYVFIQCPSVSRLEWHPFTLT B8YQA0_SALSA B8YQA0_SALSA RLVRFYRSQQKVVITKVVMHPSKTLELQMKRKGFRMEVGQYVFMQCPCVSQLEWHPFTLT Q60FB9_ONCMY Q60FB9_ONCMY RLVRFYRSQQKVVITKVVMHPSKTLELQMKRKGFRMEVGQYVFMQCPCVSQLEWHPFTLT A2A237_PLEAT A2A237_PLEAT RLVRFFRSRQKVVITKVVMHPSKTLELQMKRKGFKMEVGQYVFMQCPSVSSLEWHPFTLT MATCH CONSENSUS R??R??RS???V?I??V??HP????E??M?K??F????GQY????CP??S?LE?HPFTLT

Q4SYI4_TETNG Q4SYI4_TETNG -----------------------------------CPTEKRKTFSIHLRVVGDWTERFTQ A7E3L2_CHICK A7E3L2_CHICK MVWSKDRSRGWQHSWFPLAGCHRHVENCSYIFLLECPTDTKATFGVHLKVVGDWTERFRD B2RSM1_MOUSE B2RSM1_MOUSE M----------------------------------CPTETKATFGVHFKVVGDWTERFRD NOX4_MOUSE NOX4_MOUSE M----------------------------------CPTETKATFGVHFKVVGDWTERFRD NOX4_RAT NOX4_RAT M----------------------------------CPTETKATFGVHFKVVGDWTERFRD NOX4_PONAB NOX4_PONAB M----------------------------------CPTETKATFGVHLKIVGDWTERFRD NOX4_HUMAN NOX4_HUMAN M----------------------------------CPTETKATFGVHLKIVGDWTERFRD B7Z520_HUMAN B7Z520_HUMAN M----------------------------------CPTETKATFGVHLKIVGDWTERFRD B3KQ17_HUMAN B3KQ17_HUMAN M----------------------------------CPTETKATFGVHLKIVGDWTERFRD B7Z523_HUMAN B7Z523_HUMAN M----------------------------------CPTETKATFGVHLKIVGDWTERFRD B7Z529_HUMAN B7Z529_HUMAN M----------------------------------CPTETKATFGVHLKIVGDWTERFRD B7Z535_HUMAN B7Z535_HUMAN M----------------------------------CPTETKATFGVHLKIVGDWTERFRD A3FEK2_SHEEP A3FEK2_SHEEP M----------------------------------CPTETKATFGVHLKIVGDWTERFRD Q6V1P7_BOVIN Q6V1P7_BOVIN M----------------------------------CPTETKATFGVHLKIVGDWTERFRD A7E3L0_CIOIN A7E3L0_CIOIN S----------------------------------APEEDY--FSIHVRIVGDWTTG--- NOX3_MOUSE NOX3_MOUSE S----------------------------------APQEDF--FSVHIRASGDWTEA--- NOX3_RAT NOX3_RAT S----------------------------------APQEDF--FSVHIRASGDWTEA--- A7E3L1_CANFA A7E3L1_CANFA S----------------------------------APQEDF--FSLHIRVAGDWTEA--- NOX3_HUMAN NOX3_HUMAN S----------------------------------APQEDF--FSVHIRAAGDWTAA--- Q4RP39_TETNG Q4RP39_TETNG S----------------------------------APEEDF--FSVHIRSAGDWTDK--- A7E3K4_DANRE A7E3K4_DANRE S----------------------------------APEEDF--FSVHIRSVGDWTEK--- B1H1J8_DANRE B1H1J8_DANRE S----------------------------------APEEDF--FSVHIRSVGDWTEK--- A7E3K3_CHICK A7E3K3_CHICK S----------------------------------APEEDF--FSIHIRAAGDWTEH--- Q76I23_CAVPO Q76I23_CAVPO S----------------------------------APEEVF--FPIHVRAAGDWTEN--- NOX1_RAT NOX1_RAT S----------------------------------APEEEF--FSIHIRAAGDWTEN--- A2AEK5_MOUSE A2AEK5_MOUSE S----------------------------------APEEEF--FSVHIRAAGDWTRN--- NOX1_MOUSE NOX1_MOUSE S----------------------------------APEEEF--FSVHIRAAGDWTRN--- Q811U2_MOUSE Q811U2_MOUSE S----------------------------------APEEEF--FSVHIRAAGDWTRN--- A3RF23_SHEEP A3RF23_SHEEP S----------------------------------APEED---FSIHIRAVGDWTEN--- Q8TCT3_HUMAN Q8TCT3_HUMAN S----------------------------------APEEDF--FSIHIRAAGDWTEN--- A6NGA6_HUMAN A6NGA6_HUMAN S----------------------------------APEEDF--FSIHIRAAGDWTEN--- NOX1_HUMAN NOX1_HUMAN S----------------------------------APEEDF--FSIHIRAAGDWTEN--- Q1ZYL4_HUMAN Q1ZYL4_HUMAN S----------------------------------APEEDF--FSIHIRAAGDWTEN--- Q505H9_XENTR Q505H9_XENTR S----------------------------------APEEDF--FSIHIRIVGDWTEG--- Q6GNG7_XENLA Q6GNG7_XENLA S----------------------------------APEEDF--FSIHIRIVGDWTEG--- A7E3K8_CHICK A7E3K8_CHICK S----------------------------------APEEDY--FSIHVRIVGDWTEG--- Q9N2H1_TURTR Q9N2H1_TURTR S----------------------------------APEEDF--FSIHIRIVGDWTEG--- CY24B_BISBI CY24B_BISBI S----------------------------------APEEDF--FSIHIRIVGDWTEG--- CY24B_BOVIN CY24B_BOVIN S----------------------------------APEEDF--FSIHIRIVGDWTEG--- CY24B_PIG CY24B_PIG S----------------------------------APEEDF--FSIHIRIVGDWTEG--- A7E3K7_CANFA A7E3K7_CANFA S----------------------------------APEEDF--FSIHIRIVGDWTEG--- B4DWE0_HUMAN B4DWE0_HUMAN S----------------------------------APEEDF--FSIHIRIVGDWTEG--- CY24B_HUMAN CY24B_HUMAN S----------------------------------APEEDF--FSIHIRIVGDWTEG--- Q95MN3_RABIT Q95MN3_RABIT S----------------------------------APEEDF--FSIHIRIVGDWTEG--- Q8C6S5_MOUSE Q8C6S5_MOUSE S----------------------------------APEEDF--FSIHIRIVGDWTEG--- Q3U4P0_MOUSE Q3U4P0_MOUSE S----------------------------------APEEDF--FSIHIRIVGDWTEG--- Q3U6M7_MOUSE Q3U6M7_MOUSE S----------------------------------APEEDF--FSIHIRIVGDWTEG--- Q3TVP4_MOUSE Q3TVP4_MOUSE S----------------------------------APEEDF--FSIHIRIVGDWTEG--- CY24B_MOUSE CY24B_MOUSE S----------------------------------APEEDF--FSIHIRIVGDWTEG--- Q3U6G0_MOUSE Q3U6G0_MOUSE S----------------------------------APEEDF--FSIHIRIVGDWTEG--- Q9ER28_RAT Q9ER28_RAT S----------------------------------APEEDF--FSIHIRIVGDWTEG--- Q9ERL1_RAT Q9ERL1_RAT S----------------------------------APEEDF--FSIHIRIVGDWTEG--- A7BI57_CYPCA A7BI57_CYPCA S----------------------------------APEEDH--LSVHIRIVGDWTQA--- Q7T2A7_DANRE Q7T2A7_DANRE S----------------------------------APEEDH--FSVHIRIVGDWTQA--- Q1A3S4_SINCH Q1A3S4_SINCH S----------------------------------APEEDY--FSAHIRIVGDWTQA--- Q4SEQ8_TETNG Q4SEQ8_TETNG S----------------------------------APEEDY--FSAHIRIVGDWTQA--- B8YQA0_SALSA B8YQA0_SALSA S----------------------------------APEEDH--FSVHIRIVGDWTQG--- Q60FB9_ONCMY Q60FB9_ONCMY S----------------------------------APEEDH--FSVHIRIVGDWTQG--- A2A237_PLEAT A2A237_PLEAT S----------------------------------APEEDH--FSVHIRIVGDWTEG--- MATCH .* : : *.: **** CONSENSUS ????????????????????????????????????P?E????F??H????GDWT?????

Q4SYI4_TETNG Q4SYI4_TETNG LLLPGSRTDLKILPVVQQRQYH------------KIYVDGPFGSPSEEVFNYDVSLCVAG A7E3L2_CHICK A7E3L2_CHICK LLLLHSNQDAEILPIFQQRHYP------------KLYVDGPFGSPFEESLNYEVSLCVAG B2RSM1_MOUSE B2RSM1_MOUSE LLLPPSSQDSEILPFIHSRNYP------------KLYIDGPFGSPFEESLNYEVSLCVAG NOX4_MOUSE NOX4_MOUSE LLLPPSSQDSEILPFIHSRNYP------------KLYIDGPFGSPFEESLNYEVSLCVAG NOX4_RAT NOX4_RAT LLLPPSSQDSEILPFIQSRNYP------------KLYIDGPFGSPFEESLNYEVSLCVAG NOX4_PONAB NOX4_PONAB LLLPPSSQDSEILPFIQSRNYP------------KLYIDGPFGSPFEESLNYEVSLCVAG NOX4_HUMAN NOX4_HUMAN LLLPPSSQDSEILPFIQSRNYP------------KLYIDGPFGSPFEESLNYEVSLCVAG B7Z520_HUMAN B7Z520_HUMAN LLLPPSSQDSEILPFIQSRNYP------------K------------------------- B3KQ17_HUMAN B3KQ17_HUMAN LLLPPSSQDSEILPFIQSRNYP------------KLYIDGPFGSPFEESLNYEVSLCVAG B7Z523_HUMAN B7Z523_HUMAN LLLPPSSQDSEILPFIQSRNYP------------KLYIDGPFGSPFEESLNYEVSLCVAG B7Z529_HUMAN B7Z529_HUMAN LLLPPSSQDSEILPFIQSRNYP------------KLYIDGPFGSPFEESLNYEVSLCVAG B7Z535_HUMAN B7Z535_HUMAN LLLPPSSQDSEILPFIQSRNYP------------KLYIDGPFGSPFEESLNYEVSLCVAG A3FEK2_SHEEP A3FEK2_SHEEP LLLPPSSQDSEILPFIQSRNYP------------KLYIDGPFGSPFEESLNYEVSLCVAG Q6V1P7_BOVIN Q6V1P7_BOVIN LLLPPSSQDSEILPFIQSRNYP------------KLYIDGPFGSPFEESLNYEVSLCVAG A7E3L0_CIOIN A7E3L0_CIOIN -LSKVLGADEAGNEVQPSWKMP------------RLAIDGPFGTASEDVFNYPVAICVGS NOX3_MOUSE NOX3_MOUSE -LLKAFRVEGQ--APSELCSMP------------RLAVDGPFGGSLADVFHYPVSVCIAT NOX3_RAT NOX3_RAT -LLKAFGAEGQ--APSELCSMP------------RLAVDGPFGGSLADVFHYPVSVCIAT A7E3L1_CANFA A7E3L1_CANFA -LWKAFGAEGQ--ALKEPWSLP------------RLAVDGPFGTTLTDVFHYPVSVCIAA NOX3_HUMAN NOX3_HUMAN -LLEAFGAEGQ--ALQEPWSLP------------RLAVDGPFGTALTDVFHYPVCVCVAA Q4RP39_TETNG Q4RP39_TETNG -LIDIMQ------KLPEGAQGP------------KMGVDGPFGTASEDVFDYEVSMLVGA A7E3K4_DANRE A7E3K4_DANRE -LLKMVE------NLPEGGQGPKYVLLWIFTITSRMGVDGPFGTASEDVFHYEVSMLVGA B1H1J8_DANRE B1H1J8_DANRE -LLKMVE------NLPEGGQGP------------KMGVDGPFGTASEDVFHYEVSMLVGA A7E3K3_CHICK A7E3K3_CHICK -IIDTFQQQKL--EM------P------------RIKVDGPFGTASEDVFLYEVAMLVGA Q76I23_CAVPO Q76I23_CAVPO -LIRAFEQHHS--PV------P------------RIQVDGPFGTVSEDVFQYEVAVLVGA NOX1_RAT NOX1_RAT -LIRTFEQQHS--PM------P------------RIEVDGPFGTVSEDVFQYEVAVLVGA A2AEK5_MOUSE A2AEK5_MOUSE -LIRTFEQQHS--PM------P------------RIEVDGPFGTVSEDVFQYEVAVLVGA NOX1_MOUSE NOX1_MOUSE -LIRTFEQQHS--PM------P------------RIEVDGPFGTVSEDVFQYEVAVLVGA Q811U2_MOUSE Q811U2_MOUSE -LIRTFEQQHS--PM------P------------RIEVDGPFGTVSEDVFQYEVAVLVGA A3RF23_SHEEP A3RF23_SHEEP -LIRTFEQQYS--PV------P------------RIQVDGPFGTVSEDVFQYEVAVLVGA Q8TCT3_HUMAN Q8TCT3_HUMAN -LIRAFEQQYS--PI------P------------RIEVDGPFGTASEDVFQYEVAVLVGA A6NGA6_HUMAN A6NGA6_HUMAN -LIRAFEQQYS--PI------P------------RIEVDGPFGTASEDVFQYEVAVLVGA NOX1_HUMAN NOX1_HUMAN -LIRAFEQQYS--PI------P------------RIEVDGPFGTASEDVFQYEVAVLVGA Q1ZYL4_HUMAN Q1ZYL4_HUMAN -LIRAFEQQYS--PI------P------------RIEVDGPFGTASEDVFQYEVAVLVGA Q505H9_XENTR Q505H9_XENTR -LFKACGCDKT--EFQDAWKMP------------KIAVDGPFGTASEDVFSYEVAMLVGA Q6GNG7_XENLA Q6GNG7_XENLA -LFKACGCDKT--EFQDAWKMP------------KIAVDGPFGTASEDVFSYEVAMLVGA A7E3K8_CHICK A7E3K8_CHICK -LFNACGCDKQ--EFQEAWKLP------------KIAVDGPFGTASEDVFSYETVMLVGA Q9N2H1_TURTR Q9N2H1_TURTR -LFKACGCDKQ--EFQDAWKLP------------KIAVDGPFGTASEDVFSYEVVMLVGA CY24B_BISBI CY24B_BISBI -LFKACGCDKQ--EFQDAWKLP------------KIAVDGPFGTASEDVFSYEVVMLVGA CY24B_BOVIN CY24B_BOVIN -LFKACGCDKQ--EFQDAWKLP------------KIAVDGPFGTASEDVFSYEVVMLVGA CY24B_PIG CY24B_PIG -LFKACGCDKQ--EFQDAWKLP------------KIAVDGPFGTASEDVFSYQVVMLVGA A7E3K7_CANFA A7E3K7_CANFA -LFNACGCDKQ--EFQDAWKLP------------KIAVDGPFGTASEDVFSYEVVMLVGA B4DWE0_HUMAN B4DWE0_HUMAN -LFNACGCDKQ--EFQDAWKLP------------KIAVDGPFGTASEDVFSYEVVMLVGA CY24B_HUMAN CY24B_HUMAN -LFNACGCDKQ--EFQDAWKLP------------KIAVDGPFGTASEDVFSYEVVMLVGA Q95MN3_RABIT Q95MN3_RABIT -LFNACGCDKQ--EFQDAWKLP------------KIAVDGPFGTASEDVFSYEVVMLVGA Q8C6S5_MOUSE Q8C6S5_MOUSE -LFNACGCDKQ--EFQDAWKLP------------KIAVDGPFGTASEDVFSYEVVMLVGA Q3U4P0_MOUSE Q3U4P0_MOUSE -LFNACGCDKQ--EFQDASKLP------------KIAVDGPFGTASEDVFSYEVVMLVGA Q3U6M7_MOUSE Q3U6M7_MOUSE -LFNACGCDKQ--EFQDAWKLP------------KIAVDGPFGTASEDVFSYEVVMLVGA Q3TVP4_MOUSE Q3TVP4_MOUSE -LFNACGCDKQ--EFQDAWKLP------------KIAVDGPFGTASEDVFSYEVVMLVGA CY24B_MOUSE CY24B_MOUSE -LFNACGCDKQ--EFQDAWKLP------------KIAVDGPFGTASEDVFSYEVVMLVGA Q3U6G0_MOUSE Q3U6G0_MOUSE -LFNACGCDKQ--EFQDAWKLP------------KIAVDGPFGTASEDVFSYEVVMLVGA Q9ER28_RAT Q9ER28_RAT -LFKACGCDKQ--EFQDAWKLP------------KIAVDGPFGTASEDVFSYEVVMLVGA Q9ERL1_RAT Q9ERL1_RAT -LFNACGCDKQ--EFQDAWKLP------------KIAVDGPFGTASEDVFSYEVVMLVGA A7BI57_CYPCA A7BI57_CYPCA -LYTACGGDKT--VVQDAWTLP------------KVAVDGPFGTASEDVFRYEVVMLVGA Q7T2A7_DANRE Q7T2A7_DANRE -LYSACGGDKT--AVLDAWTLP------------KMAVDGPFGTASEDVFRYEAVMLVGA Q1A3S4_SINCH Q1A3S4_SINCH -LYEACGGDKT--ELQEAWKLP------------KLAIDGPFGTASEDVFRYEVVMLVGA Q4SEQ8_TETNG Q4SEQ8_TETNG -LYEACGGDRS--EPQEAWKLP------------KVAIDGPFGTASEDVFRYEVVMLVGA B8YQA0_SALSA B8YQA0_SALSA -LYEACGGDKN--ETQEAWKLP------------KMAIDGPFGTASEDVFGYEVVMLVGA Q60FB9_ONCMY Q60FB9_ONCMY -LYEACGGDKN--ETQEAWKLP------------KMAIDGPFGTASEDVFGYEVVMLVGA A2A237_PLEAT A2A237_PLEAT -IYKACGGDRT--VPQDAWKLP------------KMAIDGPFGTASEDVFRYEVVMLVGA MATCH : : CONSENSUS ?L???????????????????P????????????????DGPFG???E????YEV???V??

Q4SYI4_TETNG Q4SYI4_TETNG GIGVTPFACVLHTLL----DGWTHFRLQRLYFVWVCRELRSFYWFAELLCSVHHKLWQEN A7E3L2_CHICK A7E3L2_CHICK GIGVTPFASVLNALL----DGWKCYKLRRLYFIWVCRDVESFRWFADLLCMLHNKLWQEN B2RSM1_MOUSE B2RSM1_MOUSE GIGVTPFASILNTLL----DDWKPYKLRRLYFIWVCRDIQSFQWFADLLCVLHNKFWQEN NOX4_MOUSE NOX4_MOUSE GIGVTPFASILNTLL----DDWKPYKLRRLYFIWVCRDIQSFQWFADLLCVLHNKFWQEN NOX4_RAT NOX4_RAT GIGVTPFASILNTLL----DDWKPYKLRRLYFIWVCRDIQSFQWFADLLYVLHNKFWQEN NOX4_PONAB NOX4_PONAB GIGVTPFASILNTLL----DDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLHNKFWQEN NOX4_HUMAN NOX4_HUMAN GIGVTPFASILNTLL----DDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLHNKFWQEN B7Z520_HUMAN B7Z520_HUMAN -------------------DDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLHNKFWQEN B3KQ17_HUMAN B3KQ17_HUMAN GIGVTPFASILNTLL----DDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLHNKFWQEN B7Z523_HUMAN B7Z523_HUMAN GIGVTPFASILNTLL----DDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLHNKFWQEN B7Z529_HUMAN B7Z529_HUMAN GIGVTPFASILNTLL----DDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLHNKFWQEN B7Z535_HUMAN B7Z535_HUMAN GIGVTPFASILNTLL----DDWKPYKPRRLYFIW---------------------FWQEN A3FEK2_SHEEP A3FEK2_SHEEP GIGVTPFASILNTLL----DDWKPYKLRRLYFIWVCRDIQSFHWFADLLCVLYNKFWQEN Q6V1P7_BOVIN Q6V1P7_BOVIN GIGVTPFASILNTLL----DDWKPYKLRRLYFIWVCRDIQSFRWFADLLCVLYNKFWQEN A7E3L0_CIOIN A7E3L0_CIOIN GIGVTPFASLLKSVWYKNLNPEHEMVLKKVYFFWICPETHAFEWFGDLLKYLERQLTEIG NOX3_MOUSE NOX3_MOUSE GIGVTPFASLLKSVWYKCCESQSLPELSKVYFYWICRDAGAFEWFADLLLSLETRMSEQG NOX3_RAT NOX3_RAT GIGVTPFASLLKSVWYKCCESQSLPGLSKVYFYWICRDAAAFEWFADLLLSLETQMSEQG A7E3L1_CANFA A7E3L1_CANFA GIGVTPFASLLKSIWYK-CESQTQLKLSKVYFYWICRDPKAFEWFADLLLSLETLMSERG NOX3_HUMAN NOX3_HUMAN GIGVTPFAALLKSIWYKCSEAQTPLKLSKVYFYWICRDARAFEWFADLLLSLETRMSEQG Q4RP39_TETNG Q4RP39_TETNG GIGVTPFASILKSIWYKFKESNPKLRTRKIYFYWLCRETHAFEWFADLLQVLEKEMDERG A7E3K4_DANRE A7E3K4_DANRE GIGVTPFASILKSIWYKFKDSDPKLRTKRIYFYWLCRETHAFEWFADLLQVLEREMEERG B1H1J8_DANRE B1H1J8_DANRE GIGVTPFASILKSIWYKFKDSDPKLRTKRIYFYWLCRETHAFEWFADLLQVLEREMEERG A7E3K3_CHICK A7E3K3_CHICK GIGVTPFASILKSIWYRFQQNDQTLKTKKIYFYWLCRDTGAFTWFNDLLASLEQKMAESG Q76I23_CAVPO Q76I23_CAVPO GIGVTPFASILKSIWYKFQRADHNLKIQKIYFYWICRETGAFSWFNDLMISLEQEMEELG NOX1_RAT NOX1_RAT GIGVTPFASFLKSIWYKFQRAHNKLKTQKIYFYWICRETGAFAWFNNLLNSLEQEMDELG A2AEK5_MOUSE A2AEK5_MOUSE GIGVTPFASILKSIWYKFQRADNKLKTQK------------------------------- NOX1_MOUSE NOX1_MOUSE GIGVTPFASILKSIWYKFQRADNKLKTQKIYFYWICRETGAFAWFNNLLNSLEQEMEELG Q811U2_MOUSE Q811U2_MOUSE GIGVTPFASILKSIWYKFQRADNKLKTQKIYFYWICRETGAFAWFNNLLNSLEQEMEELG A3RF23_SHEEP A3RF23_SHEEP GIGVTPFASILKSIWYKFQHTDHNLKTQKIYFYWICREMGAFAWFNDLLASLEQEMEELG Q8TCT3_HUMAN Q8TCT3_HUMAN GIGVTPFASILKSIWYKFQCADHNLKTKKV------------------------------ A6NGA6_HUMAN A6NGA6_HUMAN GIGVTPFASILKSIWYKFQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELG NOX1_HUMAN NOX1_HUMAN GIGVTPFASILKSIWYKFQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELG Q1ZYL4_HUMAN Q1ZYL4_HUMAN GIGVTPFASILKSIWYKFQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELG Q505H9_XENTR Q505H9_XENTR GIGVTPFASVLKSVWYRYVNDASTLRLKKIYFYWLCRDTQAFEWFADLLQSLETQMQERD Q6GNG7_XENLA Q6GNG7_XENLA GIGVTPFASVLKSVWYKYVNDASTLRLKKIYFYWLCRDTQAFEWFADLLQSLETQMQERD A7E3K8_CHICK A7E3K8_CHICK GIGVTPFASVLKSVWYKYCHDATNLKLKKIYFYWLCRDTHAFEWFADLLQSLETQMQERN Q9N2H1_TURTR Q9N2H1_TURTR GIGVTPFASILKSIRYKYCNKAPNLRLKKIYFYWLCRDTHAFEWFADLLQLLETQM-QKD CY24B_BISBI CY24B_BISBI GIGVTPFASILKSVWYKYCNKAPNLRLKKIYFYWLCRDTHAFEWFADLLQLLETQMQEKN CY24B_BOVIN CY24B_BOVIN GIGVTPFASILKSVWYKYCNKAPNLRLKKIYFYWLCRDTHAFEWFADLLQLLETQMQEKN CY24B_PIG CY24B_PIG GIGVTPFASILKSVWYKYCNNATNLRLKKIYFYWLCRDTHAFEWFADLLQLLETQMQERN A7E3K7_CANFA A7E3K7_CANFA GIGVTPFASILKSVWYKYCNNATNLRLKKIYFYWLCRDTHAFEWFADLLQLLETQMQERN B4DWE0_HUMAN B4DWE0_HUMAN GIGVTPFASILKSVWYKYCNNATNLKLKKIYFYWLCRDTHAFEWFADLLQLLESQMQERN CY24B_HUMAN CY24B_HUMAN GIGVTPFASILKSVWYKYCNNATNLKLKKIYFYWLCRDTHAFEWFADLLQLLESQMQERN Q95MN3_RABIT Q95MN3_RABIT GIGVTPFASILKSVWYKYCDNATNLRLKKIYFYWLCRDTHAFEWFADLLQLLETQMQERN Q8C6S5_MOUSE Q8C6S5_MOUSE GIGVTPFASILKSVWYKYCDNATSLKLKKIYFYWLCRDTHAFEWFADLLQLLETQMQERN Q3U4P0_MOUSE Q3U4P0_MOUSE GIGVTPFASILKSVWYKYCDNATSLKLKKIYFYWLCRDTHAFEWFADLLQLLETQMQERN Q3U6M7_MOUSE Q3U6M7_MOUSE GIGVTPFASILKSVWYKYCDNATSLKLKKIYFYWLCRDTHAFEWFADLLQLLETQMQERN Q3TVP4_MOUSE Q3TVP4_MOUSE GIGVTPFASILKSVWYKYCDNATSLKLKKIYFYWLCRDTHAFEWFADLLQLLETQMQERN CY24B_MOUSE CY24B_MOUSE GIGVTPFASILKSVWYKYCDNATSLKLKKIYFYWLCRDTHAFEWFADLLQLLETQMQERN Q3U6G0_MOUSE Q3U6G0_MOUSE GIGVTPFASILKSVWYKYCDNATSLKLKKIYFYWLCRDTHAFEWFADLLQLLETQMQERN Q9ER28_RAT Q9ER28_RAT GIGVTPSASILKSVWYKYCDNATSLRLKKIYFYWLCRDTHAFEWFADLLQLLETQMQERN Q9ERL1_RAT Q9ERL1_RAT GIGVTPFASILKSVWYKYCDNATSLRLKKIYFYWLCRDTHAFEWFADLLQLLETQMQERN A7BI57_CYPCA A7BI57_CYPCA GIGVTPFASVLKSVWYKHVQENKNVFTKKIYFYWLCPETQAFEWFADLLQSLERQMIEKD Q7T2A7_DANRE Q7T2A7_DANRE GIGVTPFASVLKSVWYKHVQENQNVFTKKIYFYWLCPETQAFEWFADLLQSLEKQMSDKN Q1A3S4_SINCH Q1A3S4_SINCH GIGVTPFASILKSVWYKRIQNNQDVFTKKIYFYWLCPETQAFEWFADLLQSLEGQMTEKG Q4SEQ8_TETNG Q4SEQ8_TETNG GIGVTPFASILKSVWYKHIQKNQEVFTKKIYFYWLCPETEAFEWFADLLQSLEGQMADKG B8YQA0_SALSA B8YQA0_SALSA GIGVTPFASVLKSVWYKHIQENQNVFTKKIYFYWLCPETQAFEWFADLLQSLEGQMTEKG Q60FB9_ONCMY Q60FB9_ONCMY GIGVTPFASVLKSVWYKHIQENQNVFTKKIYFYWLCPETQAFEWFADLLQSLEGQMTGKG A2A237_PLEAT A2A237_PLEAT GIGVTPFASILKSVWYKHIQKNQNVFTKKIYFYWLCPETQAFEWFADLLQSLEGQMTEKG MATCH : CONSENSUS GIGVTPFAS?L???????????????????YF?W?CR????F?WF?DLL??L????????

Q4SYI4_TETNG Q4SYI4_TETNG RPDYFNMKLYVS------QTDTLQVMSEEKYRPITS---RLLVGRPRWKLLLNEVGKTNK A7E3L2_CHICK A7E3L2_CHICK RPDYINIQLYLS------QTDGIQKIIGEKYQALNS---RLLIGRPRWKLLFDEIAKYNR B2RSM1_MOUSE B2RSM1_MOUSE RPDFVNIQLYLS------QTDGIQKIIGEKYHTLNS---RLFIGRPRWKLLFDEIAKCNR NOX4_MOUSE NOX4_MOUSE RPDFVNIQLYLS------QTDGIQKIIGEKYHTLNS---RLFIGRPRWKLLFDEIAKCNR NOX4_RAT NOX4_RAT RPDFVNIQLYLS------QTDGIQKIIGEKYHTLNS---RLFIGRPRWKLLFDEIAKCNR NOX4_PONAB NOX4_PONAB RPDYVNIQLYLS------QTDGIQKIIGEKYHALNS---RLFIGRPRWKLLFDEIAKYNR NOX4_HUMAN NOX4_HUMAN RPDYVNIQLYLS------QTDGIQKIIGEKYHALNS---RLFIGRPRWKLLFDEIAKYNR B7Z520_HUMAN B7Z520_HUMAN RPDYVNIQLYLS------QTDGIQKIIGEKYHALNS---RLFIGRPRWKLLFDEIAKYNR B3KQ17_HUMAN B3KQ17_HUMAN RPDYVNIQLYLS------QTDGIQKIIGEKYHALNS---RLFIGRPRWKLLFDEIAKYNR B7Z523_HUMAN B7Z523_HUMAN RPDYVNIQLYLS------QTDGIQKIIGEKYHALNS---RLFIGRPRWKLLFDEIAKYNR B7Z529_HUMAN B7Z529_HUMAN RPDYVNIQLYLS------QTDGIQKIIGEKYHALNS---RLFIGRPRWKLLFDEIAKYNR B7Z535_HUMAN B7Z535_HUMAN GPDYVNIQLYLS------QTDGIQKIIGEKYHALNS---RLFIGRPRWKLLFDEIAKYNR A3FEK2_SHEEP A3FEK2_SHEEP RPDYVNIQLYLS------QTDGIQKIIGEKYQALNS---RLFIGRPRWKLLFDEIAKCNR Q6V1P7_BOVIN Q6V1P7_BOVIN RPDYVNIQLYLS------QTDGIQKIIGEKYQALNS---RLFIGRPRWK----------- A7E3L0_CIOIN A7E3L0_CIOIN RQDLIEYHIYLTRGWDHKQAKAIYAHEEDTHDVITGLEQKTNYGRPNWDEIFSKTARDYP NOX3_MOUSE NOX3_MOUSE KAHLLSYHIYLT-GWDENQAIHIALHWDESLDVITGLKQKAFYGRPNWNDEFKQIAYNHP NOX3_RAT NOX3_RAT KAHLLSYHIYLT-GWDEYQAIHIALHWDESLDVITGLKQKTFYGRPNWNEEFKQIAYNHP A7E3L1_CANFA A7E3L1_CANFA KAHFLSYHIFLT-SWDENQAVHIALHWDENTDVVTGLKQKTFYGRPNWSNEFRQLAYAHP NOX3_HUMAN NOX3_HUMAN KTHFLSYHIFLT-GWDENQALHIALHWDENTDVITGLKQKTFYGRPNWNNEFKQIAYNHP Q4RP39_TETNG Q4RP39_TETNG MGDFLTYKLYLT-KWDQSHADHIMVHSDQDIDVVTGLRQKTYYGRPAWDKEFEQVRKENP A7E3K4_DANRE A7E3K4_DANRE MRDFLTYKLYLT-GWDQSHADHAMVHFDKDTDIITGLKQKTHYGRPNWDKEFEQVRQENP B1H1J8_DANRE B1H1J8_DANRE MRDFLTYKLYLT-GWDQSHADHAMVHFDKDTDIITGLKQKTHYGRPNWDKEFEQVRQENP A7E3K3_CHICK A7E3K3_CHICK KADFLTYRLFLT-GWDTSIANNAALHFDTVTDTVTGLRQKTIFGRPRWDTEFSAVATAHP Q76I23_CAVPO Q76I23_CAVPO KVGFLNYRLFLT-GWDSNIAGHAALNFDKATDILTGLKQKTYFGRPKWENEFSTIATAHP NOX1_RAT NOX1_RAT KPDFLNYRLFLT-GWDSNIAGHAALNFDRATDVLTGLKQKTSFGRPMWDNEFSRIATAHP A2AEK5_MOUSE A2AEK5_MOUSE -------------------AGHAALNFDRATDILTGLKQKTSFGRPMWDNEFSRIATAHP NOX1_MOUSE NOX1_MOUSE KMDFLNYRLFLT-GWDSNIAGHAALNFDRATDILTGLKQKTSFGRPMWDNEFSRIATAHP Q811U2_MOUSE Q811U2_MOUSE KMDFLNYRLFLT-GWDSNIAGHAALNFDRATDILTGLKQKTSFGRPMWDNEFSRIATAHP A3RF23_SHEEP A3RF23_SHEEP KVGFLNYRLFLT-GWDSNFAGHAALNFDKANDILTGLKQKTFFGRPMWDNEFSTIATAHP Q8TCT3_HUMAN Q8TCT3_HUMAN --------------------GHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHP A6NGA6_HUMAN A6NGA6_HUMAN KVGFLNYRLFLT-GWDSNIVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHP NOX1_HUMAN NOX1_HUMAN KVGFLNYRLFLT-GWDSNIVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHP Q1ZYL4_HUMAN Q1ZYL4_HUMAN KVGFLNYRLFLT-GWDSNIVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHP Q505H9_XENTR Q505H9_XENTR NANFLVYNIYLT-GWDESQATAFSLHHDQEKDVITGLKQKTLYGRPNWENEFKTIANAHT Q6GNG7_XENLA Q6GNG7_XENLA NANFLVYNIYLT-GWDESQATAFSLHHDEEKDVITGLKQKTLYGRPNWENEFKTIANQHQ A7E3K8_CHICK A7E3K8_CHICK NAEFLSYNIYLT-GWDETQATHFVMHHEEEKDVITGLKQKTLYGRPNWENEFKTIARQHP Q9N2H1_TURTR Q9N2H1_TURTR NAGFLSYNIYLT-GWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIGSQHP CY24B_BISBI CY24B_BISBI NTDFLSYNICLT-GWDESQASHFAMHHDEEKDVITGLKQKTLYGRPNWDNEFKTIGSQHP CY24B_BOVIN CY24B_BOVIN NTDFLSYNICLT-GWDESQASHFAMHHDEEKDVITGLKQKTLYGRPNWDNEFKTIGSQHP CY24B_PIG CY24B_PIG NAGFLSYNIYLT-GWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASQHP A7E3K7_CANFA A7E3K7_CANFA NAGFLSYNIYLT-GWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASQHP B4DWE0_HUMAN B4DWE0_HUMAN NAGFLSYNIYLT-GWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASQHP CY24B_HUMAN CY24B_HUMAN NAGFLSYNIYLT-GWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASQHP Q95MN3_RABIT Q95MN3_RABIT NAGFLSYNIYLT-GWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASQHP Q8C6S5_MOUSE Q8C6S5_MOUSE NANFLSYNIYLT-GWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASEHP Q3U4P0_MOUSE Q3U4P0_MOUSE NANFLSYNIYLT-GWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASEHP Q3U6M7_MOUSE Q3U6M7_MOUSE NANFLSYNIYLT-GWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASEHP Q3TVP4_MOUSE Q3TVP4_MOUSE NANFLSYNIYLT-GWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASEHP CY24B_MOUSE CY24B_MOUSE NANFLSYNIYLT-GWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASEHP Q3U6G0_MOUSE Q3U6G0_MOUSE NANFLSYNIYLT-GWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASEHP Q9ER28_RAT Q9ER28_RAT NANFLSYNIYLT-GWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASQHP Q9ERL1_RAT Q9ERL1_RAT NANFLSYNIYLT-GWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASQHP A7BI57_CYPCA A7BI57_CYPCA MSDFLSYNIYLT-RWKDAEAAHFRVQYEAEDDPITGLKQKTRYGKPNWDNEFSAIATQHP Q7T2A7_DANRE Q7T2A7_DANRE MSDFLSYNIYLT-RWKDAEAAHLRVQYEAEDDPITGLKQKTRYGKPNWDNEFSLIASQHP Q1A3S4_SINCH Q1A3S4_SINCH VTDFLSYNIYLT-RWKETEAAHFRVHHEAENDPITGLKQKTLYGKPNWDNEFTSIASKHP Q4SEQ8_TETNG Q4SEQ8_TETNG MTDFLSYNIYLT-RWKEKEAAHFRVHHEAENDPITGLKQKTLYGKPNWDHEFASIASQHP B8YQA0_SALSA B8YQA0_SALSA MVDFLSYNIYLT-RWKETEAAHFRVHHEAENDPITGLKQKTLYGKPNWDNEFTTIGTKHP Q60FB9_ONCMY Q60FB9_ONCMY MVDFLSYNIYLT-RWKETEAAHFRVHHEAENDPITGLKQKTLYGKPNWDNEFTTIGTKHP A2A237_PLEAT A2A237_PLEAT MANFLSYNIYLT-RWKETEAAHFRVHHEAESDPITGLKQKTLYGKPNWDSEFSSIGNNHP MATCH :.. : *:* *. CONSENSUS ??????????L????????????????????????????????GRP?W???F??IA????

Q4SYI4_TETNG Q4SYI4_TETNG HKRVGVFCCGPKAISSTLHRLCNSFQSS---ETVFEFNKESFN A7E3L2_CHICK A7E3L2_CHICK RKTIGVFCCGPSKMSKILHKLSNSSNPY---GTRFEYNKESFS B2RSM1_MOUSE B2RSM1_MOUSE GKTVGVFCCGPSSISKTLHSLSNRNNSY---GTKFEYNKESFS NOX4_MOUSE NOX4_MOUSE GKTVGVFCCGPSSISKTLHSLSNRNNSY---GTKFEYNKESFS NOX4_RAT NOX4_RAT GKTVGVFCCGPSSISKTLHNLSNRNNSY---GTKFEYNKESFS NOX4_PONAB NOX4_PONAB GKTVGVFCCGPNSLSKTLHKLSNQINSY---GTRFEYNKESFS NOX4_HUMAN NOX4_HUMAN GKTVGVFCCGPNSLSKTLHKLSNQNNSY---GTRFEYNKESFS B7Z520_HUMAN B7Z520_HUMAN GKTVGVFCCGPNSLSKTLHKLSNQNNSY---GTRFEYNKESFS B3KQ17_HUMAN B3KQ17_HUMAN GKTVGVFCCGPNSLSKTLHKLSNQNNSY---GTRFEYNKESFS B7Z523_HUMAN B7Z523_HUMAN GKTVGVFCCGPNSLSKTLHKLSNQNNSY---GTRFEYNKESFS B7Z529_HUMAN B7Z529_HUMAN GKTVGVFCCGPNSLSKTLHKLSNQNNSY---GTRFEYNKESFS B7Z535_HUMAN B7Z535_HUMAN GKTVGVFCCGPNSLSKTLHKLSNQNNSY---GTRFEYNKESFS A3FEK2_SHEEP A3FEK2_SHEEP GKTVG-------------------------------------- Q6V1P7_BOVIN Q6V1P7_BOVIN ------------------------------------------- A7E3L0_CIOIN A7E3L0_CIOIN NTHIGVFFCGVAALSAKLHKMSNKHSGG---GVYFHYNKENF- NOX3_MOUSE NOX3_MOUSE SSSIGVFFCGSKAMSKTLQKMCRLYSSVDPRGVHFYYNKENF- NOX3_RAT NOX3_RAT SSSIGVFFCGPKAMSKTLQKMCRLYSSSDPRGVHFYYNKENF- A7E3L1_CANFA A7E3L1_CANFA SSSIGVFFCGPKALSKTLQRMCHLYSSADPRGVHFYYNKESF- NOX3_HUMAN NOX3_HUMAN SSSIGVFFCGPKALSRTLQKMCHLYSSADPRGVHFYYNKESF- Q4RP39_TETNG Q4RP39_TETNG TSVVGTFLCGPEALAEVLEKKCVKYSDVDPRKTKFYFNKENF- A7E3K4_DANRE A7E3K4_DANRE SSVVGTFLCGPQALAKDLEKKCVKYSDVDPRRTKFYFNKENF- B1H1J8_DANRE B1H1J8_DANRE SSVVGTFLCGPQALAKDLEKKCVKYSDVDPRRTKFYFNKENF- A7E3K3_CHICK A7E3K3_CHICK RSVVGVFLCGPEALAKVLRRSCHQHSSLDPRKVKFYFNKENF- Q76I23_CAVPO Q76I23_CAVPO KSVVGVFLCGPQTLGKEPAQM-----------LSPIFQSRSR- NOX1_RAT NOX1_RAT KSVVGVFLCGPPTLAKSLRKCCRRYSSLDPRKVQFYFNKETF- A2AEK5_MOUSE A2AEK5_MOUSE KSAVGVFLCGPRTLAKSLRKRCQRYSSLDPRKVQFYFNKETF- NOX1_MOUSE NOX1_MOUSE KSAVGVFLCGPRTLAKSLRKRCQRYSSLDPRKVQFYFNKETF- Q811U2_MOUSE Q811U2_MOUSE KSAVGVFLCGPRTLAK--------------------------- A3RF23_SHEEP A3RF23_SHEEP K------------------------------------------ Q8TCT3_HUMAN Q8TCT3_HUMAN KSVVGVFLCGPRTLAKSLRKCCHRYSSLDPRKVQFYFNKENF- A6NGA6_HUMAN A6NGA6_HUMAN KSVVGVFLCGPRTLAKSLRKCCHRYSSLDPRKVQFYFNKENF- NOX1_HUMAN NOX1_HUMAN KSVVGVFLCGPRTLAKSLRKCCHRYSSLDPRKVQFYFNKENF- Q1ZYL4_HUMAN Q1ZYL4_HUMAN KSVVGVFLCGPRTLAKSLRKCCHRYSSLDPRKVQFYFNKENF- Q505H9_XENTR Q505H9_XENTR SSRVGVFLCGPESLAETLNKQSIANSTVDPRGVHFIFNKENF- Q6GNG7_XENLA Q6GNG7_XENLA SSRVGVFLCGPESLAETLSKQSIANSSVDPRGVHFIFNKENF- A7E3K8_CHICK A7E3K8_CHICK GSRIGVFLCGPEGLADTLNKQSISNSEADPRGVHFIFNKENF- Q9N2H1_TURTR Q9N2H1_TURTR STRIGVFLCGPEALAETLNKQCISNSDSGPRGVHLIFNKENF- CY24B_BISBI CY24B_BISBI NTRIGVFLCGPEALADTLNKQCISNSDSGPRGVHFIFNKENF- CY24B_BOVIN CY24B_BOVIN NTRIGVFLCGPEALADTLNKQCISNSDSGPRGVHFIFNKENF- CY24B_PIG CY24B_PIG TTRIGVFLCGPEALAETLNKQCISNSDSSPRGVHFIFNKENF- A7E3K7_CANFA A7E3K7_CANFA NTRIGVFLCGPEALAETLSKQCISNSESGPRGVHFIFNKENF- B4DWE0_HUMAN B4DWE0_HUMAN NTRVGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKENF- CY24B_HUMAN CY24B_HUMAN NTRIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKENF- Q95MN3_RABIT Q95MN3_RABIT NTRIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKENF- Q8C6S5_MOUSE Q8C6S5_MOUSE NTTIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKENF- Q3U4P0_MOUSE Q3U4P0_MOUSE NTTIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKENF- Q3U6M7_MOUSE Q3U6M7_MOUSE NTTIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKENF- Q3TVP4_MOUSE Q3TVP4_MOUSE NTTIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKENF- CY24B_MOUSE CY24B_MOUSE NTTIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKENF- Q3U6G0_MOUSE Q3U6G0_MOUSE NTTIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKENF- Q9ER28_RAT Q9ER28_RAT NTRIGVFLCGPEALAKTLSKQSISNSESGPRGVHFIFNKENF- Q9ERL1_RAT Q9ERL1_RAT NTRIGVFLCGPEALAKTLSKQSISNSESGPRGVHFIFNKENF- A7BI57_CYPCA A7BI57_CYPCA GSKVGVFLCGPTALATALGKQCISHTES---GTEFIFNKENF- Q7T2A7_DANRE Q7T2A7_DANRE GTKVGVFLCGPTALGKALSKQCLSHTEG---GTEFIFNKENF- Q1A3S4_SINCH Q1A3S4_SINCH GTKVGVFLCGPPQLGKSLEKQSLSHSEA---DVKFIFNKENF- Q4SEQ8_TETNG Q4SEQ8_TETNG RSKVGVFLCGPPKLGQSLQKQCLSYSGA---DVKFIFNKENF- B8YQA0_SALSA B8YQA0_SALSA EKKVGVFLCGPTQLADVLEKQCLSHSEA---GVKFIFNKENF- Q60FB9_ONCMY Q60FB9_ONCMY EKKVGVFLCGPTQLADVLEKQCLSHSEA---GVKFIFNKENF- A2A237_PLEAT A2A237_PLEAT GSKVGVFLCGPTQLADVLGKQCQSHTEG---GVKFIFNKENF- MATCH CONSENSUS ????GVF?CGP??L???L?K??????????????F??NKE?F?


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