Alignment of the gene Family HBG003801 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
B0UXP5_DANRE B0UXP5_DANRE ------------------------------------------------------------ Q9W6T6_DANRE Q9W6T6_DANRE ASAVNVSS------------EQENRDPDRPRVTRRNRGNYRTAAADLEYLQRPSYCDAAF Q98SW6_XENLA Q98SW6_XENLA ASAACAAEL-----------GASGEAAAQPRVVRRRGRSRRVAPPDHDYLQRPSYCDANF Q9DEF4_XENLA Q9DEF4_XENLA ASAACAAEL-----------GASGEAAAQPRVVRRRGRSRRVAPPDHDYLQRPSYCDANF PTC1_CHICK PTC1_CHICK ASAADALEPESGSSTAGGGSHPVRAARSARGRRRRSGGTRRAAAPDREYLQRPSYCDAAF Q5VZC2_HUMAN Q5VZC2_HUMAN ------------------------------------------------------------ PTC1_HUMAN PTC1_HUMAN ASAGNAAEPQDRGGGGSGCIGAPGRPAGG-GRRRRTGGLRRAAAPDRDYLHRPSYCDAAF Q6TKP9_HUMAN Q6TKP9_HUMAN ------------------------------------------------------------ Q2MHN4_MERUN Q2MHN4_MERUN ASAGNAA-------------GALGRQAG--GGRRRRTGGPHRAAPDRDYLHRPSYCDAAF PTC1_MOUSE PTC1_MOUSE ASAGNAA-------------GALGRQAG--GGRRRRTGGPHRAAPDRDYLHRPSYCDAAF Q6UY90_RAT Q6UY90_RAT ASAGNAA-------------GALGRQAG--GGRRRRTGGPHRAAPDRDYLHRPSYCDAAF Q9Z2A1_RAT Q9Z2A1_RAT ASAGNAA-------------GALGRQAG--GGRRRRTGGPHRAAPDRDYLHRPSYCDAAF PTC2_HUMAN PTC2_HUMAN TRSPP-------------------------LRELPPSYTPPARTAAPQIL---------- PTC2_MOUSE PTC2_MOUSE VRPLS-------------------------LGELPPSYTPPARSSAPHIL---------- Q4RVD6_TETNG Q4RVD6_TETNG ------------------------------------------------------------ PTC1_DANRE PTC1_DANRE ASDPRDP-------------GPAGGV----FGDLPPSYTRSPPPVNSDLLRRPSYCHAAF Q90XB9_CHICK Q90XB9_CHICK ----------------------------------MPAEPPRSAPPRA------------- Q6IRA5_XENLA Q6IRA5_XENLA ASVPPCA-------------GERG------FTHLPPGYKSKQPAPSSDLLRRPSYCHAAF Q9DEF3_XENLA Q9DEF3_XENLA ASVPPCA-------------GERG------FTHLPPGYKSKQPAPSSDLLRRPSYCHAAF MATCH CONSENSUS ????????????????????????????????????????????????????????????

B0UXP5_DANRE B0UXP5_DANRE ------------------------------------------------------------ Q9W6T6_DANRE Q9W6T6_DANRE ALEQISEGNATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLRAAN Q98SW6_XENLA Q98SW6_XENLA ALQQISEGKAIGRKAPLWLRAFFQRQLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLRAAN Q9DEF4_XENLA Q9DEF4_XENLA ALQQISEGKAIGRKAPLWLRAFFQRQLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLRAAN PTC1_CHICK PTC1_CHICK ALEQIAKGRATGRRAPLWLRAKFQRLLFNLGCYIQKNCGKFLVVGLL-YSAFAVGLRAAN Q5VZC2_HUMAN Q5VZC2_HUMAN ------------------------------------------------------------ PTC1_HUMAN PTC1_HUMAN ALEQISKGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAAN Q6TKP9_HUMAN Q6TKP9_HUMAN ------------------------------------------------------------ Q2MHN4_MERUN Q2MHN4_MERUN ALEQISKGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAAN PTC1_MOUSE PTC1_MOUSE ALEQISKGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAAN Q6UY90_RAT Q6UY90_RAT ALEQISKGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAAN Q9Z2A1_RAT Q9Z2A1_RAT AMEQISKGKATGRKAPLWLRAKFQRLLFKLGCYIQKDCGKFLVVGLLIFGAFAVGLKAAN PTC2_HUMAN PTC2_HUMAN ---------AGSLKAPLWLRAYFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAI PTC2_MOUSE PTC2_MOUSE ---------AGSLQAPLWLRAYFQGLLFSLGCRIQKHCGKVLFLGLVAFGALALGLRVAV Q4RVD6_TETNG Q4RVD6_TETNG -------------KTPLWIRARLQALLFTLGCYIQRHCGKVLFIGLLVFGALSVGLRVAT PTC1_DANRE PTC1_DANRE ALKQISKGKAVGQKAPLWIRARFQAFLFSLGCHIQRHCGKVLFIGLLVFGALSVGLRVAA Q90XB9_CHICK Q90XB9_CHICK AAAALRKALPEGRGAPLWLRARFQALLFALGCRIQRHCGKVLFVGLLLFGALAVGLRVAS Q6IRA5_XENLA Q6IRA5_XENLA ALKQIAKGKAVGQKAPLWLRAQFQALLFILGCSIQRHCGKVLFIGLLVFGALAVGLRVAS Q9DEF3_XENLA Q9DEF3_XENLA ALKQIAKGKAVGQKAPLWLRAQFQALLFSLGCSIQRHCGKVLFIGLLVFGALAVGLRVAS MATCH CONSENSUS ???????????????PLW?RA??Q??LF?LGC?IQ??CGK?L??GL????A???GL??A?

B0UXP5_DANRE B0UXP5_DANRE ------------GGRVNQELKYTRQKIGEEAMFSPQLMIQTPRQEGANILTVEALKQHLD Q9W6T6_DANRE Q9W6T6_DANRE LETDVEKLWVEVGGRVNQELKYTRQKIGEEAMFSPQLMIQTPRQEGANILTVEALKQHLD Q98SW6_XENLA Q98SW6_XENLA LETNVEELWVEVGGRVSRELDYTRQKIGEEAMFNPQLMIQTPLEDGANVLTTEALLQHLH Q9DEF4_XENLA Q9DEF4_XENLA LETNVEELWVEVGGRVSRELDYTRQKIGEEAMFNPQLMIQTPLEDGANVLTTEALLQHLH PTC1_CHICK PTC1_CHICK LETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPQEDGTNVLTTEALRQHLD Q5VZC2_HUMAN Q5VZC2_HUMAN -------------------------------MFNPQLMIQTPKEEGANVLTTEALLQHLD PTC1_HUMAN PTC1_HUMAN LETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLD Q6TKP9_HUMAN Q6TKP9_HUMAN ------------------------------------------------------------ Q2MHN4_MERUN Q2MHN4_MERUN LETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLD PTC1_MOUSE PTC1_MOUSE LETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLD Q6UY90_RAT Q6UY90_RAT LETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLD Q9Z2A1_RAT Q9Z2A1_RAT LETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLD PTC2_HUMAN PTC2_HUMAN IETNLEQLWVEVGSRVSQELHYTKEKLGEEAAYTSQMLIQTARQEGENILTPEALGLHLQ PTC2_MOUSE PTC2_MOUSE IETDLEQLWVEVGSRVSQELHYTKEKLGEEAAYTSQMLIQTAHQEGGNVLTPEALDLHLQ Q4RVD6_TETNG Q4RVD6_TETNG IETNIEKLWVKSGSRVSTELQYTREKQGEDAVFTSQMLIQTPKEKGANILTQEAFLVHMK PTC1_DANRE PTC1_DANRE IETDIEKLWVEAGSRVSKELRYTKEKQGEESVFTSQMLIQTPKQEGTNILTQEALLLHLE Q90XB9_CHICK Q90XB9_CHICK VETDIEHLWVEAGSRVSQELRYTKEKLGEESVYTSQMLIQTPKREGENILTQEALQLHLE Q6IRA5_XENLA Q6IRA5_XENLA IETDIERLWVEAGSRVSHELRYTKEKLGEESVYTSQMLIQTPKREGGNILTNEALLLHLR Q9DEF3_XENLA Q9DEF3_XENLA IETDIERLWVEAGSRVSHELRYTKEKLGEESVYTSQMLIQTPKREGENILTHEALLLHLR MATCH CONSENSUS ?ET??E?LWV??G?RV??EL?YT??K?GEE?????Q??IQTP???G?N?LT?EAL??HL?

B0UXP5_DANRE B0UXP5_DANRE SAIKASRVHVYMYNRQWTLEHLCYKSGELVTETNVVDQILEKLHPCLVITPLDCFWEGAK Q9W6T6_DANRE Q9W6T6_DANRE SAIKASRVHVYMYNRQWTLEHLCYKSGELVTETNVVDQILEKLHPCLVITPLDCFWEGAK Q98SW6_XENLA Q98SW6_XENLA SALEATKVQVYMYNKPWKLEELCFKSGELITEAVYVSQIIDSMYPCLIITPLDCFWEGAK Q9DEF4_XENLA Q9DEF4_XENLA SALEATKVQVYMYNKPWKLEELCFKSGELITEAVYVSQIIDSMYPCLIITPLDCFWEGAK PTC1_CHICK PTC1_CHICK SALQASRVHVYMYNRQWKLEHLCYKSGELITEAGYMDQIIEYLYPCLIITPLDCFWEGAK Q5VZC2_HUMAN Q5VZC2_HUMAN SALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAK PTC1_HUMAN PTC1_HUMAN SALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAK Q6TKP9_HUMAN Q6TKP9_HUMAN ------------------------------------------------------------ Q2MHN4_MERUN Q2MHN4_MERUN SALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAK PTC1_MOUSE PTC1_MOUSE SALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAK Q6UY90_RAT Q6UY90_RAT SALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAK Q9Z2A1_RAT Q9Z2A1_RAT SALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAK PTC2_HUMAN PTC2_HUMAN AALTASKVQVSLYGKSWDLNKICYKSGVPLIENGMIERMIEKLFPCVILTPLDCFWEGAK PTC2_MOUSE PTC2_MOUSE AALTASKVQVSLYGKSWDLNKICYKSGVPLIENGMIERMIEKLFPCVILTPLDCFWEGAK Q4RVD6_TETNG Q4RVD6_TETNG AALSASEIKVSLFGKTWDLNKICYKSGVPIIENVMIERMIEKLYPCMIITPLDCFWDGSK PTC1_DANRE PTC1_DANRE AALSASKVQVSLYGKSWDLNKICFKSGVPIIENVMIERMIDKLFPCMIVTPLDCFWEGSK Q90XB9_CHICK Q90XB9_CHICK AALAASKVQVSLYGKSWDLNKICYKSGVPIIENGMIERMIEKLFPCVILTPLDCFWEGAK Q6IRA5_XENLA Q6IRA5_XENLA AALAASKVQVSMYGKSWDLNKICYKSGVPIIENGMIERMIEKLFPCVIITPLDCFWEGSQ Q9DEF3_XENLA Q9DEF3_XENLA AALAASKVQVSMYGKSWDLNKICYKSGVPIIENGMIERMIEKLFPCVIITPLDCFWEGSQ MATCH CONSENSUS ?AL?AS?V?V??Y???W?L???C?KSG????E???????I??L?PC?I?TPLDCFWEG?K

B0UXP5_DANRE B0UXP5_DANRE LHSGTFYLP-----------------------GKPPLQWTNFDPMGFIAELKMLKYQVDS Q9W6T6_DANRE Q9W6T6_DANRE LHSGTFYLP-----------------------GKPPLQWTNFDPMGFIAELKMLKYQVDS Q98SW6_XENLA Q98SW6_XENLA LQSGMAYLP-----------------------GKDILQWTNFDPLELLEELKKGKLHIDI Q9DEF4_XENLA Q9DEF4_XENLA LQSGMAYLP-----------------------GKDILQWTNFDPLELLEELKKGKLHIDI PTC1_CHICK PTC1_CHICK LQSGTAYLL-----------------------GKPPLQWINFDPLEFLEELKKINYQVES Q5VZC2_HUMAN Q5VZC2_HUMAN LQSGTAYLL-----------------------GKPPLRWTNFDPLEFLEELKKINYQVDS PTC1_HUMAN PTC1_HUMAN LQSGTAYLL-----------------------GKPPLRWTNFDPLEFLEELKKINYQVDS Q6TKP9_HUMAN Q6TKP9_HUMAN ------------------------------------------------------------ Q2MHN4_MERUN Q2MHN4_MERUN LQSGTAYLL-----------------------GKPPLRWTNFDPLEFLEELKKINYQVDS PTC1_MOUSE PTC1_MOUSE LQSGTAYLL-----------------------GKPPLRWTNFDPLEFLEELKKINYQVDS Q6UY90_RAT Q6UY90_RAT LQSGTAYLL-----------------------GKPPLRWTNFDPLEFLEELKKINYQVDS Q9Z2A1_RAT Q9Z2A1_RAT LQSGTAYLL-----------------------GKPPLRWTNFDPLEFLEELKKINYQVDS PTC2_HUMAN PTC2_HUMAN LQGGSAYLP-----------------------GRPDIQWTNLDPEQLLEELGPFA-SLEG PTC2_MOUSE PTC2_MOUSE LQGGSAYLP-----------------------GRPDIQWTNLDPQQLLEELGPFA-SLEG Q4RVD6_TETNG Q4RVD6_TETNG LQGGSVYLPFSPMHSPAQPTLDLIDLFFLRPGDSPYIKWMNLDPVKLVRKLSQ-SFSLEG PTC1_DANRE PTC1_DANRE LQGGSAYLP-----------------------GMPDIQWMNLDPLKLMEELSQFT-SLEG Q90XB9_CHICK Q90XB9_CHICK LQGGSAYLP-----------------------GRPDIQWSNLDPLQLMEELGQFT-SLEG Q6IRA5_XENLA Q6IRA5_XENLA LQGGSAYLP-----------------------GRADIQWTNLDPIKLMEELGQFT-SLDG Q9DEF3_XENLA Q9DEF3_XENLA LQGGSAYLP-----------------------GRADIQWTNLDPIRLMEELGQFT-SLDG MATCH CONSENSUS LQ?G??YL????????????????????????G?????W?N?DP?????EL?????????

B0UXP5_DANRE B0UXP5_DANRE WEEMLVKADVGQGYMNRPCLNPADPDCPLSAPNKNTTGPFDVAPVLTGGCYGLSKKYMHW Q9W6T6_DANRE Q9W6T6_DANRE WEEMLVKADVGQGYMNRPCLNPADPDCPLSAPNKNTTGPFDVAPVLTGGCYGLSKKYMHW Q98SW6_XENLA Q98SW6_XENLA WEEMINKAEVGHGYMDRPCLNPSDKNCPYTAPNKNSTKPVDVSLILSGGCYGLSKKYMHW Q9DEF4_XENLA Q9DEF4_XENLA WEEMINKAEVGHGYMDRPCLNPSDKNCPYTAPNKNSTKPVDVSLILSGGCYGLSKKYMHW PTC1_CHICK PTC1_CHICK WEEMLNKAEVGHGYMDRPCLNPADPDCPITAPNKNSTKPLDVALVLSGGCYGLSRKYMHW Q5VZC2_HUMAN Q5VZC2_HUMAN WEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLSRKYMHW PTC1_HUMAN PTC1_HUMAN WEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLSRKYMHW Q6TKP9_HUMAN Q6TKP9_HUMAN ------------------------------------------------------------ Q2MHN4_MERUN Q2MHN4_MERUN WEEMLDKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDVALVLNGGCQGLSRKYMHW PTC1_MOUSE PTC1_MOUSE WEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDVALVLNGGCQGLSRKYMHW Q6UY90_RAT Q6UY90_RAT WEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDVALVLNGGCQGLSRKYMHW Q9Z2A1_RAT Q9Z2A1_RAT WEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDVALVLNGGCQGLSRKYMHW PTC2_HUMAN PTC2_HUMAN FRELLDKAQVGQAYVGRPCLHPDDLHCPPSAPNHHSRQAPNVAHELSGGCHGFSHKFMHW PTC2_MOUSE PTC2_MOUSE FRELLDKAQVGQAYVGRPCLDPDDPHCPPSAPNRHSRQAPNVAQELSGGCHGFSHKFMHW Q4RVD6_TETNG Q4RVD6_TETNG FKKMLDKSEVGHAYMDRPCLNPLDRDCPRSAPNKAKGESPDIARHLQDGCRGLSKKFMHW PTC1_DANRE PTC1_DANRE FREMLDKAQVGHAYMNRPCLDPSDTDCPHSAPNKDPWQVPNIAAELQGGCHGFSKKFMHW Q90XB9_CHICK Q90XB9_CHICK FKELLDKAEVGQAYMERPCLDPRDPHCPSSAPNKQSQQSPDIPAELSGGCHGFSRKFMRW Q6IRA5_XENLA Q6IRA5_XENLA FKEMLDKAEVGQGYMERPCLDPTDSDCPESSPNKKTKKKPDIVSTLRGGCYGFSKKFMYW Q9DEF3_XENLA Q9DEF3_XENLA FKEMLDKAEVGQAYMERPCLDPTDSDCPESSPNKKTKKNPDIVSTLRGGCYGFSKKFMYW MATCH CONSENSUS ??E?L?KA?VG??YM?RPCL?P?D??CP??APNK???????????L?GGC?G?S?K?M?W

B0UXP5_DANRE B0UXP5_DANRE QEELIVGGTKKNDSGKLLSAQAFQTMFQLMTPKQMYEHLKGYDEVSHINWNEDKAAAILE Q9W6T6_DANRE Q9W6T6_DANRE QEELIVGGTKKNDSGKLLSAQAFQTMFQLMTPKQMYEHLKGYDEVSHINWNEDKAAAILE Q98SW6_XENLA Q98SW6_XENLA QEELIIGGTVKNASGQIVSALALQTMFQLMTPKQMYEHFKGHEVVSHMNWNEDKAAAILE Q9DEF4_XENLA Q9DEF4_XENLA QEELIIGGTVKNASGQIVSALALQTMFQLMTPKQMYEHFKGHEVVSHMNWNEDKAAAILE PTC1_CHICK PTC1_CHICK QEELIIGGTVKNSSGKLVSAQALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILE Q5VZC2_HUMAN Q5VZC2_HUMAN QEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILE PTC1_HUMAN PTC1_HUMAN QEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILE Q6TKP9_HUMAN Q6TKP9_HUMAN ------------------------------------------------------------ Q2MHN4_MERUN Q2MHN4_MERUN QEELIVGGTVKNASGKLVSAHALQTMFQLMTPKQMYEHFRGYDYVSHINWNEDRAAAILE PTC1_MOUSE PTC1_MOUSE QEELIVGGTVKNATGKLVSAHALQTMFQLMTPKQMYEHFRGYDYVSHINWNEDRAAAILE Q6UY90_RAT Q6UY90_RAT QEELIVGGTVKNATGKLVSAHALQTMFQLMTPKQMYEHFRGYDYVSHINWNEDRAAAILE Q9Z2A1_RAT Q9Z2A1_RAT QEELIVGGTVKNATGKLVSAHALQTMFQLMTPKQMYEHFRGYDYVSHINWNEDRAAAILE PTC2_HUMAN PTC2_HUMAN QEELLLGGMARDPQGELLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQASTVLQ PTC2_MOUSE PTC2_MOUSE QEELLLGGTARDLQGQLLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQASMVLQ Q4RVD6_TETNG Q4RVD6_TETNG QEELILGGRVKGSKNALLSAEALQTTFLLMSPKQLYEHFKDNYEIHNMNWNEEKAKAIIE PTC1_DANRE PTC1_DANRE QEELILGERVKDSQNALQSAEALQTMFLLMSPKQLYEHFKDDYEIHDINWNEDKATAILE Q90XB9_CHICK Q90XB9_CHICK QEELILGGTTKDSQGKLLSAEALQTMFLLMSPRQLYEHFKDDYEIHDISWSEEKAGAILE Q6IRA5_XENLA Q6IRA5_XENLA QKELILGGMLKGPDGELKSAEALQTMYLLMSPGQLYEHFKDDYEIHDINWNEEKAAAILE Q9DEF3_XENLA Q9DEF3_XENLA QKELILGGMLKGPNGELKSAEALQTMYLLMSPGQLFEHFKDDYEIHDINWNEEKAAAILE MATCH CONSENSUS QEELI?GG??K???G?L?SA?ALQT?F?LM?P?Q?YEHF??????????W?E??A?AILE

B0UXP5_DANRE B0UXP5_DANRE AWQRKYSEAVQQSVPVNSSQKVLTFTTTTLEDILKSFSDVSVIRIASGYLLMLAYA---- Q9W6T6_DANRE Q9W6T6_DANRE AWQRKYSEAVQQSVPVNSSQKVLTFTTTTLEDILKPFSDVSVIRIASGYLLMLAYA---- Q98SW6_XENLA Q98SW6_XENLA AWQRTYVQVVHQSVPQNSSQKVLPFTTTTLDDILKSFSDVSVIRVASGYLLMLAYA---- Q9DEF4_XENLA Q9DEF4_XENLA AWQRTYVQVVHQSVPQNSSQKVLPFTTTTLDDILKSFSDVSVIRVASGYLLMLAYA---- PTC1_CHICK PTC1_CHICK AWQRMYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYA---- Q5VZC2_HUMAN Q5VZC2_HUMAN AWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYA---- PTC1_HUMAN PTC1_HUMAN AWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYA---- Q6TKP9_HUMAN Q6TKP9_HUMAN --------VVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYA---- Q2MHN4_MERUN Q2MHN4_MERUN AWQRTYVEVVHQSVAPNSTQKVLSFTTTTLDDILKSFSDVSVIRGASGYLLMLAYA---- PTC1_MOUSE PTC1_MOUSE AWQRTYVEVVHQSVAPNSTQKVLPFTTTTLDDILKSFSDVSVIRVASGYLLMLAYA---- Q6UY90_RAT Q6UY90_RAT AWQRTYVEVVHQSVAPNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYA---- Q9Z2A1_RAT Q9Z2A1_RAT AWQRTYVEVVHQSVAPNSTQKVLSFTTRTLDDILKSFSDVSVIRVASGYLLMLAYA---- PTC2_HUMAN PTC2_HUMAN AWQRRFVQLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAYA---- PTC2_MOUSE PTC2_MOUSE AWQRRFVQLAQEALPANASQQIHAFSSTTLDDILRAFSEVSTTRVVGGYLLMLAYA---- Q4RVD6_TETNG Q4RVD6_TETNG SWQREFTAVVHKSIPENSNHSIYAFSTIAFDDIMQSFSNVSVIRVAGGYLLMVRTVQSLI PTC1_DANRE PTC1_DANRE SWQRKFVEVVHGSIPQNSSSNVYAFSTTTLNDIMKSFSDVSVIRVAGGYLLMLAYA---- Q90XB9_CHICK Q90XB9_CHICK AWQRKFVELAQDSIPPNATQNIHAFSTTTLNDIMKSFSDVSAIRVAGGYLLMLAYA---- Q6IRA5_XENLA Q6IRA5_XENLA SWQRKFVEQAQQSIPQNSSQDIHAFSTTTLNDIMKSFSDVSAIRVAGGYLLMLAYA---- Q9DEF3_XENLA Q9DEF3_XENLA SWQRKFVEQAQQSVPQNSSQDIHAFSTTTLNDIMKSFSDVSAIRVAGGYLLMLAYA---- MATCH .: ::. *:. .: .*:: :::**::.**:**. * ..*****: . CONSENSUS ?WQR????????S???NS?Q????F?TTTL?DI?KSFSDVS?IRVA?GYLLMLAYA????

B0UXP5_DANRE B0UXP5_DANRE CLTMLRWD---------------------------------CAKSQGAVG------LAGV Q9W6T6_DANRE Q9W6T6_DANRE CLTMLRWD---------------------------------CAKSQGAVG------LAGV Q98SW6_XENLA Q98SW6_XENLA CLTMLRWD---------------------------------CAKSQGAVG------LAGV Q9DEF4_XENLA Q9DEF4_XENLA CLTMLRWD---------------------------------CAKSQGAVG------LAGV PTC1_CHICK PTC1_CHICK CLTMLRWD---------------------------------CAKSQGAVG------LAGV Q5VZC2_HUMAN Q5VZC2_HUMAN CLTMLRWD---------------------------------CSKSQGAVG------LAGV PTC1_HUMAN PTC1_HUMAN CLTMLRWD---------------------------------CSKSQGAVG------LAGV Q6TKP9_HUMAN Q6TKP9_HUMAN CLTMLRWD---------------------------------CSKSQGAVG------LAGV Q2MHN4_MERUN Q2MHN4_MERUN CLTMLRWD---------------------------------CSKSQGAVG------LAGV PTC1_MOUSE PTC1_MOUSE CLTMLRWD---------------------------------CSKSQGAVG------LAGV Q6UY90_RAT Q6UY90_RAT CLTMLRWD---------------------------------CSKSQGAVG------LAGV Q9Z2A1_RAT Q9Z2A1_RAT CLTMLRWD---------------------------------CSKSQGAVG------LAGV PTC2_HUMAN PTC2_HUMAN CVTMLRWD---------------------------------CAQSQGSVG------LAGV PTC2_MOUSE PTC2_MOUSE CVTMLRWD---------------------------------CAQSQGAVG------LAGV Q4RVD6_TETNG Q4RVD6_TETNG HLIMARHSLKPATLLISYIIPVAGLRLSDHAKVGLCQVSGGCGASRGAVDGFVGGCRTGP PTC1_DANRE PTC1_DANRE CVTMLRWD---------------------------------CAKSQGAVG------LAGV Q90XB9_CHICK Q90XB9_CHICK CVTMLRWD---------------------------------CSKSQGAVG------LAGV Q6IRA5_XENLA Q6IRA5_XENLA CATMLRWD---------------------------------CSKSQGAVG------LAGV Q9DEF3_XENLA Q9DEF3_XENLA CVTLLRWD---------------------------------CSKSQGAVG------LAGV MATCH : * . *. *:*:*. :* CONSENSUS C?TMLRWD?????????????????????????????????C?KSQGAVG??????LAGV

B0UXP5_DANRE B0UXP5_DANRE LLVTLSVA-----AGLGLCSLLGISFNAATT------------------QVLPFLALGVG Q9W6T6_DANRE Q9W6T6_DANRE LLVTLSVA-----AGLGLCSLLGISFNAATT------------------QVLPFLALGVG Q98SW6_XENLA Q98SW6_XENLA LLVALSVA-----AGLGLCSLIGISFNAATT------------------QVLPFLALGVG Q9DEF4_XENLA Q9DEF4_XENLA LLVALSVA-----AGLGLCSLIGISFNAATT------------------QVLPFLALGVG PTC1_CHICK PTC1_CHICK LLVALSVA-----AGLGLCSLIGISFNAATT------------------QVLPFLALGVG Q5VZC2_HUMAN Q5VZC2_HUMAN LLVALSVA-----AGLGLCSLIGISFNAATT------------------QVLPFLALGVG PTC1_HUMAN PTC1_HUMAN LLVALSVA-----AGLGLCSLIGISFNAATT------------------QVLPFLALGVG Q6TKP9_HUMAN Q6TKP9_HUMAN LLVALSVA-----AGLGLCSLIGISFNAATT------------------QVLPFLALGVG Q2MHN4_MERUN Q2MHN4_MERUN LLVALSVA-----AGLGLCSLIGISFNAATT------------------QVLPFLALGVG PTC1_MOUSE PTC1_MOUSE LLVALSVA-----AGLGLCSLIGISFNAATT------------------QVLPFLALGVG Q6UY90_RAT Q6UY90_RAT LLVALSVA-----AGLGLCSLIGISFNAATT------------------QVLPFLALGVG Q9Z2A1_RAT Q9Z2A1_RAT LLVALSVA-----AGLGLCSLIGISFNAATT------------------QVLPFLALGVG PTC2_HUMAN PTC2_HUMAN LLVALAVA-----SGLGLCALLGITFNAATT------------------QVLPFLALGIG PTC2_MOUSE PTC2_MOUSE LLVALAVA-----SGLGLCALLGITFNAATT------------------QVLPFLALGIG Q4RVD6_TETNG Q4RVD6_TETNG LLPARPLPQCCHHPGMNLIGLLCVCISAVGSKVFLTGPLQRFIVTISYLQVLPFLALGIG PTC1_DANRE PTC1_DANRE LLVALSVA-----AGLGLCSLLGLSFNAATT------------------QVLPSLALGIG Q90XB9_CHICK Q90XB9_CHICK LLVALSVA-----SGLGLCSLLGISFNAATT------------------QVLPFLALGIG Q6IRA5_XENLA Q6IRA5_XENLA LLVALSVA-----SGLGLCSLLGISFNAATT------------------QVLPFLALGIG Q9DEF3_XENLA Q9DEF3_XENLA LLVALSVA-----SGLGLCSLLGISFNAATT------------------QVLPFLALGIG MATCH ** : .:. .*:.* .*: : :.*. : **** ****:* CONSENSUS LLVALSVA??????GLGLCSL?GISFNAATT??????????????????QVLPFLALG?G

B0UXP5_DANRE B0UXP5_DANRE VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR Q9W6T6_DANRE Q9W6T6_DANRE VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVVLTSISNVTAFFMAALIPIPALR Q98SW6_XENLA Q98SW6_XENLA VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR Q9DEF4_XENLA Q9DEF4_XENLA VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR PTC1_CHICK PTC1_CHICK VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR Q5VZC2_HUMAN Q5VZC2_HUMAN VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR PTC1_HUMAN PTC1_HUMAN VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR Q6TKP9_HUMAN Q6TKP9_HUMAN VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR Q2MHN4_MERUN Q2MHN4_MERUN VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR PTC1_MOUSE PTC1_MOUSE VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR Q6UY90_RAT Q6UY90_RAT VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR Q9Z2A1_RAT Q9Z2A1_RAT VDDVFLLAHAFSETGQNKRIPIEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR PTC2_HUMAN PTC2_HUMAN VDDVFLLAHAFTEALPG--TPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALR PTC2_MOUSE PTC2_MOUSE VDDIFLLAHAFTKAPPD--TPLPERMGECLRSTGTSVALTSVNNMVAFFMAALVPIPALR Q4RVD6_TETNG Q4RVD6_TETNG VDDMFLLAHSFRETGSD--IPLEERMGNCLRRTGTSIALTSINNMTAFFMAAIVPIPALR PTC1_DANRE PTC1_DANRE VDDMFLLGHSFTETRSN--IPFKERTGDCLRRTGTSVALTSVNNMIAFFMAALVPIPALR Q90XB9_CHICK Q90XB9_CHICK VDDMFLLAHAFTETSQH--IPFKERTGECLRRTGTSVALTSVSNMIAFFMAALVPIPALR Q6IRA5_XENLA Q6IRA5_XENLA VDDMFLLAHAFTETSLS--TPFKERTGECLRRTGTSVALTSINNMIAFFMAALVPIPALR Q9DEF3_XENLA Q9DEF3_XENLA VDDMFLLAHAFTETSRS--TPFKDRTGECLRRTGTSVTLTSINNMIAFFMAALVPIPALR MATCH ***:***.*:* :: *: :* *:**: **:*:.***:.*: **:***::****** CONSENSUS VDD?FLLAHAF?ET??????P???RTGECL?RTG?SVALTSI?N??AFFMAAL?PIPALR

B0UXP5_DANRE B0UXP5_DANRE AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRFDIFCCFVSPCANRVIQLEPQAAY Q9W6T6_DANRE Q9W6T6_DANRE AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRFDIFCCFVSPCANRVIQLEPQAAY Q98SW6_XENLA Q98SW6_XENLA AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREVRRLDIFCCFSSPCVSRVIQIEPQ-AY Q9DEF4_XENLA Q9DEF4_XENLA AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREVRRLDIFCCFSSPCVSRVIQIEPQ-AY PTC1_CHICK PTC1_CHICK AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVTRVIQIEPQ-AY Q5VZC2_HUMAN Q5VZC2_HUMAN AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQ-AY PTC1_HUMAN PTC1_HUMAN AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQ-AY Q6TKP9_HUMAN Q6TKP9_HUMAN AFSLQAAVVLVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQ-AY Q2MHN4_MERUN Q2MHN4_MERUN AFSLQAAVVVVFNFAMVLLILPAILSMDLYRREDRRSDIFCCFTSPCVSRVIQVEPQ-AY PTC1_MOUSE PTC1_MOUSE AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQ-AY Q6UY90_RAT Q6UY90_RAT AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQ-AY Q9Z2A1_RAT Q9Z2A1_RAT AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSLV--------- PTC2_HUMAN PTC2_HUMAN AFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCCFSSPCSAQVIQILPQ-EL PTC2_MOUSE PTC2_MOUSE AFSLQAAIVVGCNFAAVMLVFPAILSLDLRRRHRQRLDVLCCFSSPCSAQVIQMLPQ-EL Q4RVD6_TETNG Q4RVD6_TETNG VFSLQAAIVVVLNLVMVLLIFPAILCLDLYRREAKRLDILCCLYIPCSDQVTPLSPN-EL PTC1_DANRE PTC1_DANRE AFSLQAAVVVVFNFAMALLIFPAILSLDLHRREDKRLDILCCFYSPCSSRVIQIQPQ-EL Q90XB9_CHICK Q90XB9_CHICK AFSLQAAVVVVFNFAMVLFIFPAILSLDLYRREKRRLDILCCFYSPCSSRVIQIQPQ-EL Q6IRA5_XENLA Q6IRA5_XENLA AFSLQAAVVVVFNFAMVLLIFPAILSLDLHRREDQRLDILCCFYSPCSSRVIQIQPQ-EF Q9DEF3_XENLA Q9DEF3_XENLA AFSLQAAVIVVFNFAMVLLIFPAILSLDLQRREDQRLDILCCFYSPCSSRVIQIQPQ-EF MATCH .******::: .:. .::::****.:** **. :* *::**: ** * CONSENSUS AFSLQAAVVVVFNFAMVLLIFPAILS?DL?RRE??RLDI?CCF?SPC???VIQ??PQ???

B0UXP5_DANRE B0UXP5_DANRE ADSSADSSRYSPPPSYSSHSFAQHTQITMQSTVQLRTEYDPRTQAYYTTAEPHSHISVQP Q9W6T6_DANRE Q9W6T6_DANRE ADSSADSSRYSPPPSYSSHSFAQHTQITMQSTVQLRTEYDPRTQAYYTTGEPHSHISVQP Q98SW6_XENLA Q98SW6_XENLA TDNN-DNTRYSLPPTYSSHSFAHETQITMQSTVQLRTEYDPRTQLYYTTAQPRSEISVQP Q9DEF4_XENLA Q9DEF4_XENLA TDNN-DNTRYSLPPTYSSHSFAHETQITMQSTVQLRTEYDPRTQLYYTTAQPRSEISVQP PTC1_CHICK PTC1_CHICK AEN--DNICYSSPPPYSSHSFAHETQITMQSTVQLRTEYDPHTQAYYTTAEPRSEISVQP Q5VZC2_HUMAN Q5VZC2_HUMAN TDTH-DNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQP PTC1_HUMAN PTC1_HUMAN TDTH-DNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQP Q6TKP9_HUMAN Q6TKP9_HUMAN TDTH-DNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQP Q2MHN4_MERUN Q2MHN4_MERUN TEPH-SNTRYSPPPPYSSHSFAHETHITMQSTVQLRTEYDLHTHVYYTTAEPRSEISVQP PTC1_MOUSE PTC1_MOUSE TEPH-SNTRYSPPPPYTSHSFAHETHITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQP Q6UY90_RAT Q6UY90_RAT TEPH-SNTRYSPPPPYSSHSFAHETHITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQP Q9Z2A1_RAT Q9Z2A1_RAT ------------------------------------------------------------ PTC2_HUMAN PTC2_HUMAN GDGT------------VPVGIAHLT-----ATVQAFTHCEASSQHVVTILPPQAHLVP-- PTC2_MOUSE PTC2_MOUSE GDRA------------VPVGIAHLT-----ATVQAFTHCEASSQHVVTILPPQAHLLS-- Q4RVD6_TETNG Q4RVD6_TETNG SDAR----EQSPAPTVTTTG----TQFT--TTVQAFTECDEREQHIVTILHSTSQISNSA PTC1_DANRE PTC1_DANRE SDANDNHQRAPATPTYTGSTITTSTHIT--TTVQAFTQCDAAGQHIVTILPPTSQISTTP Q90XB9_CHICK Q90XB9_CHICK ADAN-DNHASTVP--YGHPGVATSTQIT--TTVQAFTQCDPSGHHIVTVLPPTSQVCTSP Q6IRA5_XENLA Q6IRA5_XENLA SDAN-DNHTYH-PSSYGNPTITTSTQIT--TTVQAFTQCDPSGHHIVTILPPTSQISTSP Q9DEF3_XENLA Q9DEF3_XENLA SDAN-DNHTYH-PSSYGNPTITTSTQIT--TTVQAFTQCDPSGHHIVTILPPTSQISTSP MATCH CONSENSUS ????????????????????????T??T???TVQ??T??D???????T???P?S??????

B0UXP5_DANRE B0UXP5_DANRE YAPNTNPNPNPNRNNNNNNCTNNSSSAVPGVATDTASCQSPDGAS-STRDLLSQFG--DS Q9W6T6_DANRE Q9W6T6_DANRE YAPNTNPNPNPNRNNNDNNCTNSSSSAVPGVATDTASCQSPDGAS-STRDLLSQFG--DS Q98SW6_XENLA Q98SW6_XENLA AA----------------------------STPQDVSGQTPESTS-STRDLISQFSVHGG Q9DEF4_XENLA Q9DEF4_XENLA AA----------------------------STPQDVSGQTPESTS-STRDLISQFSVHGG PTC1_CHICK PTC1_CHICK VT----------------------------VTQDSLSCQSPESAS-STRDLLSQFS--DS Q5VZC2_HUMAN Q5VZC2_HUMAN VT----------------------------VTQDTLSCQSPESTS-STRDLLSQFS--DS PTC1_HUMAN PTC1_HUMAN VT----------------------------VTQDTLSCQSPESTS-STRDLLSQFS--DS Q6TKP9_HUMAN Q6TKP9_HUMAN VT----------------------------VTQDTLSCQSPESTS-STRDLLSQFS--DS Q2MHN4_MERUN Q2MHN4_MERUN VT----------------------------VTQDTLSCQSPESTS-STRDLLSQFS--DS PTC1_MOUSE PTC1_MOUSE VT----------------------------VTQDNLSCQSPESTS-STRDLLSQFS--DS Q6UY90_RAT Q6UY90_RAT VT----------------------------ITQDTLSCQSPESTS-STRDLLSQFS--DS Q9Z2A1_RAT Q9Z2A1_RAT ------------------------------------------------------------ PTC2_HUMAN PTC2_HUMAN ------------------------------PPSDPLGSELFSPGG-STRDLLGQEEETRQ PTC2_MOUSE PTC2_MOUSE ------------------------------PASDPLGSELYSPGG-STRDLLSQEEGTGP Q4RVD6_TETNG Q4RVD6_TETNG PS---------------------IISCSTSQPQDPYGSQLFTPTSGSTRNLFTQGEETKL PTC1_DANRE PTC1_DANRE PS---------------------MVLSTPTPTTDPYGSQVFTTSS-STRDLLAQVEEPKE Q90XB9_CHICK Q90XB9_CHICK AV--------------------------LLPPADPLGSQVFTPSS-STRDLLAQLDEAKG Q6IRA5_XENLA Q6IRA5_XENLA SV--------------------------IVPTMDPLGSQVFSPSS-STRDLLAQLDESKE Q9DEF3_XENLA Q9DEF3_XENLA SV--------------------------IVPTMDPLGSQIFTPSS-STRDLLAQLDESKE MATCH CONSENSUS ?????????????????????????????????D????Q?????S?STRDL??Q??????

B0UXP5_DANRE B0UXP5_DANRE GIRCLDSPYSRWTFASFAEKHYAPFLLQSTTKVVVIFLFLALLGVSLYGTTRVRDGLELT Q9W6T6_DANRE Q9W6T6_DANRE GIRCLDSPYSRWTFASFAEKHYAPFLLQSTTKVVVIFLFLALLGVSLYGTTRVRDGLELT Q98SW6_XENLA Q98SW6_XENLA SMQC--TPDSKWTLSSFAEKHYAPFLLKPKTKVAVILGFLALLSVSLYGTTRVRDGLDLT Q9DEF4_XENLA Q9DEF4_XENLA SMQC--TPDSKWTLSSFAEKHYAPFLLKPKTKVAVILGFLALLSVSLYGTTRVRDGLDLT PTC1_CHICK PTC1_CHICK SVHCLEPPCTKWTLSTFAEKHYAPFLLKPKAKVVVIFLFLGLLGLSLYGTTRVRDGLDLT Q5VZC2_HUMAN Q5VZC2_HUMAN SLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLT PTC1_HUMAN PTC1_HUMAN SLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLT Q6TKP9_HUMAN Q6TKP9_HUMAN SLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLT Q2MHN4_MERUN Q2MHN4_MERUN SLHCLEPPCTKWTLSSFAEKHYAPFLLRPKAKAVVILLFLVLLGVSLYGTTRVRDGLDLT PTC1_MOUSE PTC1_MOUSE SLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKVVVILLFLGLLGVSLYGTTRVRDGLDLT Q6UY90_RAT Q6UY90_RAT SLHCLEPPCTKWTLSSFAEKHYAPFLLRPKAKVVVILLFLGLLGVSLYGTTRVRDGLDLT Q9Z2A1_RAT Q9Z2A1_RAT ------------------------------------------------------------ PTC2_HUMAN PTC2_HUMAN KAACKSLPCARWNLAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALT PTC2_MOUSE PTC2_MOUSE QAACRPLLCAHWTLAHFARYQFAPLLLQTRAKALVLLFFGALLGLSLYGATLVQDGLALT Q4RVD6_TETNG Q4RVD6_TETNG GKKFTLMPSLNWNLSSFARDKYAPFLLKPKSKVAVIIFFLGLLGISLYGTTMVHDGLYLT PTC1_DANRE PTC1_DANRE GRECVPLPFFRWNLSSFAREKYAPLLLKPETKTVVVVVFVALLSLSLYGTTMVHDGLYLT Q90XB9_CHICK Q90XB9_CHICK GRECVPLPLCRWSLSDFAREKYAPLLLQTQTKVVVVVLFLALLGLSLYGTTMVHDGLYLT Q6IRA5_XENLA Q6IRA5_XENLA KRECVPLPFLKWSLSDFAREKYAPVLLKAETKGIVVALFMALLGLGLYGTTMVHDGLYLT Q9DEF3_XENLA Q9DEF3_XENLA KRECVPLPFLKWSLSDFAREKYAPVLLKAETKGIVVTLFMALLGLGLYGTTMVHDGLYLT MATCH CONSENSUS ???C???P???W?L??FA???YAP?LL????K??V???F??LL??SLYGTT?V?DGL?LT

B0UXP5_DANRE B0UXP5_DANRE DIVPRETGEYDFIRAQFRYFSFYNMYVVTQRA-DYAQIQPQLYELHQRFGSVKYILREEN Q9W6T6_DANRE Q9W6T6_DANRE DIVPRETGEYDFIRAQFRYSSFYNMYVVTQRV-DYAQIQPQLYELHQRFGSVKYILREEN Q98SW6_XENLA Q98SW6_XENLA DIVPRETREYDFIATQFKYFSFYHMYVVTQKA-DYPRAQRLLYELHKSFVGVRYVLLEGN Q9DEF4_XENLA Q9DEF4_XENLA DIVPRETREYDFIATQFKYFSFYHMYVVTQKA-DYPRAQRLLYELHKSFVGVRYVLLEGN PTC1_CHICK PTC1_CHICK DIVPRDTREYDFIAAQFKYFSFYNMYIVTQKA-DYPNVQHLLYELHRSFSNVTYVLLEGD Q5VZC2_HUMAN Q5VZC2_HUMAN DIVPRETREYDFIAAQFKYFSFYNMYIVTQKA-DYPNIQHLLYDLHRSFSNVKYVMLEEN PTC1_HUMAN PTC1_HUMAN DIVPRETREYDFIAAQFKYFSFYNMYIVTQKA-DYPNIQHLLYDLHRSFSNVKYVMLEEN Q6TKP9_HUMAN Q6TKP9_HUMAN DIVPRETREYDFIAAQFKYFSFYNMYIVTQKA-DYPNIQHLLYDLHRSFSNVKYVMLEEN Q2MHN4_MERUN Q2MHN4_MERUN DIVPRETREYDFIAAQFKYFSFYNMYIVTQKA-DYPNIQHLLYDLHKSFSNVKYVMLEEN PTC1_MOUSE PTC1_MOUSE DIVPRETREYDFIAAQFKYFSFYNMYIVTQKA-DYPNIQHLLYDLHKSFSNVKYVMLEEN Q6UY90_RAT Q6UY90_RAT DIVPRETREYDFIAAQFKYFSFYNMYIVTQKA-DYPNIQHLLYDLHKSFSSVKYVMLEEN Q9Z2A1_RAT Q9Z2A1_RAT ------------------------------------------------------------ PTC2_HUMAN PTC2_HUMAN DVVPRGTKEHAFLSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPA PTC2_MOUSE PTC2_MOUSE DVVPRGTKEHAFLSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPA Q4RVD6_TETNG Q4RVD6_TETNG DVVPRDTKEYNFIDAQFKYFSFYNMYLVTMDGFDYTRSQKLLMQLHDSFNSIKYVVKDSN PTC1_DANRE PTC1_DANRE DIVPRDTQEYEFITAQFKYFSFYNMYLVTMDGFDYARSQRQLLQLHNAFNSVKYVVKDGN Q90XB9_CHICK Q90XB9_CHICK DIVPRDTKAHAFISAQFKYFSFYNMFIVTKGGFHYPGAQAALLSLHQAFSTVKYVVREGN Q6IRA5_XENLA Q6IRA5_XENLA DIIPRETKEYNFISAQFKYFSFYNMFIVTKDGFNYPKAQESLYDLHEAFGSVRYVVREEG Q9DEF3_XENLA Q9DEF3_XENLA DIVPRETKEYNFISAQFKYFSFYNMFIVTKDGFDYPKAQESLYDLHEAFGSVKYVVREEG MATCH CONSENSUS D?VPR?T?E??FI?AQF?YFSFY?M??VT????DY???Q??L??LH??F????YV?????

B0UXP5_DANRE B0UXP5_DANRE GQLPRMWLHYFRDWLLGLQEAFDKDWQAGRITQGNYRNGSDDGVLAYKLLVQTGRREKTI Q9W6T6_DANRE Q9W6T6_DANRE GQLPRMWPHYFRDWLLGLQEAFDKDWQAGRITQGNYRNGTDDGVLAYKLLVQTGRREKTI Q98SW6_XENLA Q98SW6_XENLA KQLPKMWLHYFRDWLQGLQDTFDHEWEAGKITRNDYRNASDDAVLAYKLLIQTGNSDKPI Q9DEF4_XENLA Q9DEF4_XENLA KQLPKMWLHYFRDWLQGLQDTFDHEWEAGKITRNDYRNASDDAVLAYKLLIQTGNSDKPI PTC1_CHICK PTC1_CHICK RQLPKMWLHYFRDWLQGLQDAFDSDWETGKITYSNYKNGSDDAVLAYKLLVQTGNRAKPI Q5VZC2_HUMAN Q5VZC2_HUMAN KQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPI PTC1_HUMAN PTC1_HUMAN KQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPI Q6TKP9_HUMAN Q6TKP9_HUMAN KQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPI Q2MHN4_MERUN Q2MHN4_MERUN KQLPQMWLHYFRDWLQGLQDAFDSDWETGRIMPNNYKNGSDDGVLAYKLLVQNGSRNKPI PTC1_MOUSE PTC1_MOUSE KQLPQMWLHYFRDWLQGLQDAFDSDWETGRIMPNNYKNGSDDGVLAYKLLVQTGSRDKPI Q6UY90_RAT Q6UY90_RAT KQLPQMWLHYFRDWLQGLQDAFDSDWETGRIMPNNYKNGSDDGVLAYKLLVQTGSRDKPI Q9Z2A1_RAT Q9Z2A1_RAT ------------------------------------------------------------ PTC2_HUMAN PTC2_HUMAN TQAPRTWLHYYRNWLQGIQAAFDQDWASGRITRHSYRNGSEDGALAYKLLIQTGDAQEPL PTC2_MOUSE PTC2_MOUSE TQAPRTWLHYYRSWLQGIQAAFDQDWASGRITCHSYRNGSEDGALAYKLLIQTGNAQEPL Q4RVD6_TETNG Q4RVD6_TETNG NKLPSMWLHYFQEWLKDLQDAFDADWQAGRLNSVGYLNGTEDGMLAYKLLIQTGSEKDPL PTC1_DANRE PTC1_DANRE HKLPRMWLHYFQDWLKGLQATFDADWEAGKITYDSYRNGTEDGALAYKPLIQTGSKKEPF Q90XB9_CHICK Q90XB9_CHICK HDLPKMWLHYFQDWLRGLQATFDRDWQAGRITHDSYRNGSEDGALAYKLLIQTGNKKEPF Q6IRA5_XENLA Q6IRA5_XENLA RDLPKMWLHYFQDWLRGLQTAFDKDWESGRMTQDNYRNGTEDGVLAYKLLIQTGNKKEPF Q9DEF3_XENLA Q9DEF3_XENLA RDLPKMWLHYFQDWLRGLQTSFDMDWESGYITQDSYRNGTEDGVLAYKLLIQTGNKKEPF MATCH CONSENSUS ??LP?MWLHYF??WL?GLQ??FD?DW??G?I????Y?NG??D??LAYKLL?QTG????P?

B0UXP5_DANRE B0UXP5_DANRE -----TRQRLVSADGIINPNAFYIYLSAWVSNDPVAYAASQANIRPHPPEWLHDRTDSIP Q9W6T6_DANRE Q9W6T6_DANRE -----TRQRLVSADGIINPNAFYIYLSAWVSNDPVAYAASQANIRPHPPEWLHDRTDSIP Q98SW6_XENLA Q98SW6_XENLA NLNQLTKQRLVDADGIIQPNAFYIYLTAWVSNDPVAYAASQANIRPHPPEWLHDKADDRP Q9DEF4_XENLA Q9DEF4_XENLA NLNQLTKQRLVDADGIIQPNAFYIYLTAWVSNDPVAYAASQANIRPHPPEWLHDKADDRP PTC1_CHICK PTC1_CHICK DISQLTKQRLVDADGIINPNAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMP Q5VZC2_HUMAN Q5VZC2_HUMAN DISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMP PTC1_HUMAN PTC1_HUMAN DISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMP Q6TKP9_HUMAN Q6TKP9_HUMAN DISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMP Q2MHN4_MERUN Q2MHN4_MERUN DISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMP PTC1_MOUSE PTC1_MOUSE DISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMP Q6UY90_RAT Q6UY90_RAT DISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMP Q9Z2A1_RAT Q9Z2A1_RAT ------------------------------------------------------------ PTC2_HUMAN PTC2_HUMAN DFSQLTTRKLVDREGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWLHDKYDTTG PTC2_MOUSE PTC2_MOUSE DFSQLTTRKLVDKEGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWLHDKYDTTG Q4RVD6_TETNG Q4RVD6_TETNG NYSLLTSRRLLDADGLVRPEVFYIYLTAWVSNDPLGYASSQANFYPPPREWIHDQYDATG PTC1_DANRE PTC1_DANRE NYSQLTSRRLVDGDGLIPPEVFYIYLTVWVSNDPLGYAASQANFYPHPREWIHDKYDTTG Q90XB9_CHICK Q90XB9_CHICK NFNQLTTRRLVDENGIIPPDTFYICLTVWASNDPLGFAASQANFYPPPPEWIHDKYDTTG Q6IRA5_XENLA Q6IRA5_XENLA NFNQLTSRRLVDEKGLIPQDAFYIYLTVWVSNDPLGYAASQANFYPQPPEWIHDRYDTTG Q9DEF3_XENLA Q9DEF3_XENLA NFNQLTSRRLVDEKGLIPQDAFYIYLTVWVSNDPLGYAASQANFYPQPPEWIHDRYDTTG MATCH CONSENSUS ????LT??RLVD??G?I?P??FYI?LT?WVSNDP???AASQAN??P??PEW?HD??D???

B0UXP5_DANRE B0UXP5_DANRE ASRLNIPAAEPIEYAQFPFYLNGLRETPQFVEAIESVRAICNNFSRQGLPSYPNGYPFLF Q9W6T6_DANRE Q9W6T6_DANRE ASRLNIPAAEPIEYAQFPFYLNGLRETPQFVEAIESVRAICNNYSRQGLPSYPNGYPFLF Q98SW6_XENLA Q98SW6_XENLA ETR-TIRAAEPIEYVQFPFYLNGLRETSDFVEAIEKVRAICNNYTSLGVSSYPNGYPFLF Q9DEF4_XENLA Q9DEF4_XENLA ETR-TIRAAEPIEYVQFPFYLNGLRETSDFVEAIEKVRAICNNYTSLGVSSYPNGYPFLF PTC1_CHICK PTC1_CHICK ETRLRIPAAEPIEYAQFPFYLNGLRETSDFVEAIEKVRAICNNYTSLGIASYPNGYPFLF Q5VZC2_HUMAN Q5VZC2_HUMAN ETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLF PTC1_HUMAN PTC1_HUMAN ETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLF Q6TKP9_HUMAN Q6TKP9_HUMAN ETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLF Q2MHN4_MERUN Q2MHN4_MERUN ETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSYPNGYPFLF PTC1_MOUSE PTC1_MOUSE ETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSYPNGYPFLF Q6UY90_RAT Q6UY90_RAT ETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSYPNGYPFLF Q9Z2A1_RAT Q9Z2A1_RAT ------------------------------------------------------------ PTC2_HUMAN PTC2_HUMAN EN-LRIPPAQPLEFAQFPFLLRGLQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPFLF PTC2_MOUSE PTC2_MOUSE EN-LRIPAAQPLEFAQFPFLLHGLQKTADFVEAIEGARAACTEAGQAGVHAYPSGSPFLF Q4RVD6_TETNG Q4RVD6_TETNG EN-LHIPAAEPLEFAQFPFYLNDLRHTSDFVEAIESVRAICEEFSRKGVFSYPDGYPFLF PTC1_DANRE PTC1_DANRE EN-LRIPAAEPLEFAQFPFYLNGLRQASDFIEAIESVRTICEEFMRQGIKNYPNGYPFLF Q90XB9_CHICK Q90XB9_CHICK EN---------------------LRS---------------------------------- Q6IRA5_XENLA Q6IRA5_XENLA EN-LRIPAAEPIEFAQFPFYLNGLRQTSDFIEAIESVRSICEEFVKQGVHSYPSGYPFLF Q9DEF3_XENLA Q9DEF3_XENLA EN-LRIPATEPIEFAQFPFYLNGLRQTSDFVEAIESVRSVCEEFVKQGVHSYPSGYPFLF MATCH CONSENSUS E????I?AA?P?E??QFPF?L?GLR?T??F?EAIE??R??C??????G???YP?G?PFLF

B0UXP5_DANRE B0UXP5_DANRE WEQYVGLRHWLLLSISVVLACTFLVCAVFLLNPWTAGIIVLVLSLMTVELFGMMGLIGIK Q9W6T6_DANRE Q9W6T6_DANRE WEQYVGLRHWLLLSISVVLACTFLVCAVFLLNPWTAGIIVLVLSLMTVELFGMMGLIGIK Q98SW6_XENLA Q98SW6_XENLA WEQYISLRHWLLLSISVVLACTFLVCALFLLNPWTAGIIVMVLALMTVELFGMMGLIGIK Q9DEF4_XENLA Q9DEF4_XENLA WEQYISLRHWLLLSISVVLACTFLVCALFLLNPWTAGIIVMVLALMTVELFGMMGLIGIK PTC1_CHICK PTC1_CHICK WEQYIGLRHWLLLSISVVLACTFLVCALFLLNPWTAGIIVVVLALMTVELFGMMGLIGIK Q5VZC2_HUMAN Q5VZC2_HUMAN WEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIK PTC1_HUMAN PTC1_HUMAN WEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIK Q6TKP9_HUMAN Q6TKP9_HUMAN WEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGII--------------------- Q2MHN4_MERUN Q2MHN4_MERUN WEQYISLRHWLLLAISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIK PTC1_MOUSE PTC1_MOUSE WEQYISLRHWLLLSISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIK Q6UY90_RAT Q6UY90_RAT WEQYISLRHWLLLAISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIK Q9Z2A1_RAT Q9Z2A1_RAT ------------------------------------------------------------ PTC2_HUMAN PTC2_HUMAN WEQYLGLRRCFLLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIK PTC2_MOUSE PTC2_MOUSE WEQYLGLRRCFLLAVCILLVCTFLVCALLLLSPWTAGLIVLVLAMMTVELFGIMGFLGIK Q4RVD6_TETNG Q4RVD6_TETNG WEQYIDLRHWFLLSISITLACTFLVCAILLFNPWIAAIIVFVLATMTVELFGVMGLINIK PTC1_DANRE PTC1_DANRE WEQYIGLRHWFLLSISVVLACTFLVCAILLLNPWTAGVIVFILPMMTVELFGIMGLIGIK Q90XB9_CHICK Q90XB9_CHICK ------------------------------------------------------------ Q6IRA5_XENLA Q6IRA5_XENLA WEQYIGLRHWFLLAISIVLACTFLVCAILLLNPWTAGIIVFILAMMTVELFGIMGLIGIK Q9DEF3_XENLA Q9DEF3_XENLA WEQYIGLRHWFLLAISIVLACTFLVCAILLLNPWTAGIIVFILAMMTVELFGIMGLIGIK MATCH CONSENSUS WEQY??LR???LL?????L?CTFLVCA??LLNPWTAG?IV??L??MTVELFG?MG???IK

B0UXP5_DANRE B0UXP5_DANRE LSAVPVVILIASVGIGVEFTVHVALAFLTAIGDRNKRAVLALEHMFAPVLDGAFSTLLGV Q9W6T6_DANRE Q9W6T6_DANRE LSAVPVVILIASVGIGVEFTVHVALAFLTAIGDRNKRAVLALEHMFAPVLDGAFSTLLGV Q98SW6_XENLA Q98SW6_XENLA LSAVPVVILIASVGIGVEFTVHVALAFLTAVGDKNRRAVLALEHMFAPVLDGAVSTLLGV Q9DEF4_XENLA Q9DEF4_XENLA LSAVPVVILIASVGIGVEFTVHVALAFLTAVGDKNRRAVLALEHMFAPVLDGAVSTLLGV PTC1_CHICK PTC1_CHICK LSAVPVVILIASVGIGVEFTVHIALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGV Q5VZC2_HUMAN Q5VZC2_HUMAN LSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGV PTC1_HUMAN PTC1_HUMAN LSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGV Q6TKP9_HUMAN Q6TKP9_HUMAN ------------------------------------------------------------ Q2MHN4_MERUN Q2MHN4_MERUN LSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNHRAMLALEHMFAPVLDGAVSTLLGV PTC1_MOUSE PTC1_MOUSE LSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNHRAMLALEHMFAPVLDGAVSTLLGV Q6UY90_RAT Q6UY90_RAT LSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNHRAMLALEHMFAPVLDGAVSTLLGV Q9Z2A1_RAT Q9Z2A1_RAT ------------------------------------------------------------ PTC2_HUMAN PTC2_HUMAN LSAIPVVILVASVGIGVEFTVHVALGFLTTQGSRNLRAAHALEHTFAPVTDGAISTLLGL PTC2_MOUSE PTC2_MOUSE LSAIPVVILVASIGIGVEFTVHVALGFLTSHGSRNLRAASALEQTFAPVTDGAVSTLLGL Q4RVD6_TETNG Q4RVD6_TETNG LSAIPVVILIASVGIGVEFTVHIAMGFLVATGNRNQRATAALERMFAPVFDGAISTLLGV PTC1_DANRE PTC1_DANRE LSAIPVVILIASVGIGVEFTVHIALGFLTAIGDRNTRSAVAMEHMFAPVIDGAISTLLGV Q90XB9_CHICK Q90XB9_CHICK ------------------------------------------------------------ Q6IRA5_XENLA Q6IRA5_XENLA LSAIPVVILIASVGIGVEFTVHVALGFLTAIGDRNQRSVLALEHMFAPVLDGAISTLLGV Q9DEF3_XENLA Q9DEF3_XENLA LSAIPVVILIASVGIGVEFTVHVALGFLTAIGDRNQRSVLALEHMFAPVLDGAISTLLGV MATCH CONSENSUS LSA?PVVIL?AS?GIGVEFTVH?A??FL???G??N?R???A?E??FAPV?DGA?STLLG?

B0UXP5_DANRE B0UXP5_DANRE LMLAGSEFDFIVRYFFAVLAILTVLGVLNGLVLLPVLLSYFGPYPEVSPADGQSRLPTPS Q9W6T6_DANRE Q9W6T6_DANRE LMLAGSEFDFIVRYFFAVLAILTVLGVLNGLVLLPVLLSYFGPCPEVSPADGRSRLPTPS Q98SW6_XENLA Q98SW6_XENLA LMLAGSEFDFIVRYFFAVLAILTLLGVLNGLVLLPVLLSFFGPYPEVSPTNGGDRLEV-S Q9DEF4_XENLA Q9DEF4_XENLA LMLAGSEFDFIVRYFFAVLAILTLLGVLNGLVLLPVLLSFFGPYPEVSPTNGGDRLEV-S PTC1_CHICK PTC1_CHICK LMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPACGRNRLPTPS Q5VZC2_HUMAN Q5VZC2_HUMAN LMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPS PTC1_HUMAN PTC1_HUMAN LMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPS Q6TKP9_HUMAN Q6TKP9_HUMAN ------------------------------------------------------------ Q2MHN4_MERUN Q2MHN4_MERUN LMLAGSEFDFIVRYFFALLAILTVLGVLNGLVLLPVLLSFFGPCPEVSPANGLDRLPTPS PTC1_MOUSE PTC1_MOUSE LMLAGSEFDFIVRYFFAVLAILTVLGVLNGLVLLPVLLSFFGPCPEVSPANGLNRLPTPS Q6UY90_RAT Q6UY90_RAT LMLAGSEFDFIVRYFFAVLAILTVLGVLNGLVLLPVLLSFFGPCPEVSPANGLNRLPTPS Q9Z2A1_RAT Q9Z2A1_RAT ------------------------------------------------------------ PTC2_HUMAN PTC2_HUMAN LMLAGSHFDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGPPPEVIQMYKESPEILSP PTC2_MOUSE PTC2_MOUSE LMLAGSNFDFIIRYFFVVLTVLTLLGLLHGLLLLPVLLSILGPPPQVVQVYKESPQTLNS Q4RVD6_TETNG Q4RVD6_TETNG LMLAGSEFEFIIRYFFAVLAILTVLGILNGLVLLPVLLSVLGPPAE-------------- PTC1_DANRE PTC1_DANRE LMLAGSEFDFIMRYFFAVLAILTLLGILNGLVLLPVLLSLMGPPAEVVPANNANHLQSPS Q90XB9_CHICK Q90XB9_CHICK ------------------------------------------------------------ Q6IRA5_XENLA Q6IRA5_XENLA LMLAGSEFDFILRYFFAVLTILTILGLLNGLVLLPVLLSLIGPPAEVTPADNGSRLPTPT Q9DEF3_XENLA Q9DEF3_XENLA LMLAGSEFDFILRYFFAVLTILTILGLLNGLVLLPVLLSLIGPPAEVTPADNSSRLPTPT MATCH CONSENSUS LMLAGS?F?FI?RYFF??L??LT?LG?L?GL?LLPVLLS??GP?????????????????

B0UXP5_DANRE B0UXP5_DANRE PEPPPQVVR----FTMRPSHTTPGAGSDSSDSEYGSNTTVSGISQELQQYNLQPNRGRSA Q9W6T6_DANRE Q9W6T6_DANRE PEPPPQVVR----FTMRPSHTTPGAGSDS------------------------------- Q98SW6_XENLA Q98SW6_XENLA QDPPPNIVR----FPEHPRPTQNG--SDSSDSEYSSQTSVSGISEELHQYNSQQCSAA-- Q9DEF4_XENLA Q9DEF4_XENLA QDPPPNIVR----FPEHPRPTQNG--SDSSDSEYSSQTSVSGISEELHQYNSQQCSAA-- PTC1_CHICK PTC1_CHICK PEPPPSIVR----FALPPGHTNNG--SDSSDSEYSSQTTVSGISEELHHYEATQSPGIPV Q5VZC2_HUMAN Q5VZC2_HUMAN PEPPPSVVR----FAMPPGHTHSG--SDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPA PTC1_HUMAN PTC1_HUMAN PEPPPSVVR----FAMPPGHTHSG--SDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPA Q6TKP9_HUMAN Q6TKP9_HUMAN ------------------------------------------------------------ Q2MHN4_MERUN Q2MHN4_MERUN PEPPPSVVR----FAVPPGHMNNG--SDSSDSEYSSQTTVSGISEELRHYEAQRGAGGPA PTC1_MOUSE PTC1_MOUSE PEPPPSVVR----FAVPPGHTNNG--SDSSDSEYSSQTTVSGISEELRQYEAQQGAGGPA Q6UY90_RAT Q6UY90_RAT PEPPPSVVR----FAVPPGHTNNG--SDSSDSEYSSQTTVSGISEELRHYEAQQGTGGPA Q9Z2A1_RAT Q9Z2A1_RAT ------------------------------------------------------------ PTC2_HUMAN PTC2_HUMAN PAPQGGGLRWGASSSLPQSFAR-------------------------------------- PTC2_MOUSE PTC2_MOUSE AAPQRGGLR----WDRPPTLPQSF------------------------------------ Q4RVD6_TETNG Q4RVD6_TETNG ------------------------------------------------------------ PTC1_DANRE PTC1_DANRE PEPMPPPMNHHGYYAGHIPKASHQAFSETSDSEY-------------------------- Q90XB9_CHICK Q90XB9_CHICK ------------------------------------------------------------ Q6IRA5_XENLA Q6IRA5_XENLA PEPLPPPLSHHAFYMNHKGFSD----PEDSSEYYSETTTTSGLEEDDPRLYERSAYIIPP Q9DEF3_XENLA Q9DEF3_XENLA PEPLPPPLSHHAFYMNHKGFSD----PEDSSEYYSETTTTSGIEEDDPQLYERSAYIIPP MATCH CONSENSUS ????????????????????????????????????????????????????????????

B0UXP5_DANRE B0UXP5_DANRE RLEEVRIATAGRQGSRQVELPMFPSCSDDSRQQQIQQHYRSSSHDAAPQPSKRYCSRDPK Q9W6T6_DANRE Q9W6T6_DANRE ------------------------------------------------------------ Q98SW6_XENLA Q98SW6_XENLA ------------------VFPRPTVVQQNSRHNPP-NQSTPPNKEARTQQQWCSNRNQRW Q9DEF4_XENLA Q9DEF4_XENLA ------------------VF---------------------------------------- PTC1_CHICK PTC1_CHICK HQVVV-------EATENPVFARSTVVQPESRHQS--SPRLQSNPEAGTQQVWHQGRQPKQ Q5VZC2_HUMAN Q5VZC2_HUMAN HQVIV-------EATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRR PTC1_HUMAN PTC1_HUMAN HQVIV-------EATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRR Q6TKP9_HUMAN Q6TKP9_HUMAN ------------------------------------------------------------ Q2MHN4_MERUN Q2MHN4_MERUN HQVIV-------EATENPVFARSTVVHPESRHHPPLNPRQQSHLDSGSLSSGRQGQQPRR PTC1_MOUSE PTC1_MOUSE HQVIV-------EATENPVFARSTVVHPDSRHQPPLTPRQQPHLDSGSLSPGRQGQQPRR Q6UY90_RAT Q6UY90_RAT HQVIV-------EATENPVFARSTVVHPDSRHQPPLNSRQQPHLDSGSLSPGRQGQQPRR Q9Z2A1_RAT Q9Z2A1_RAT ------------------------------------------------------------ PTC2_HUMAN PTC2_HUMAN ------------------------------------------------------------ PTC2_MOUSE PTC2_MOUSE ------------------------------------------------------------ Q4RVD6_TETNG Q4RVD6_TETNG ------------------------------------------------------------ PTC1_DANRE PTC1_DANRE ------------------------------------------------------------ Q90XB9_CHICK Q90XB9_CHICK ------------------------------------------------------------ Q6IRA5_XENLA Q6IRA5_XENLA KPPHIIL-----EASKDPNYPKITLVKPCKGNQDVPGNKDSQDINNSEALPGKDISHRTC Q9DEF3_XENLA Q9DEF3_XENLA KPPHIIL-----EASKDPSYPKIMLVKPCKGNQ---------DINNREALPGKDMSRRTC MATCH CONSENSUS ????????????????????????????????????????????????????????????

B0UXP5_DANRE B0UXP5_DANRE RDFGSGHPPPPHRPRMDAFETATEPGGHSGPNHRDRSGAHRPRSHNPYNP-HPSHPSTGP Q9W6T6_DANRE Q9W6T6_DANRE -----------YRLRIRL------------------------------------------ Q98SW6_XENLA Q98SW6_XENLA D-STEGSRPPPYRPRRDAFASFTE--EHAGPSTRDRSGHR-SHSHNMRQTAFAPGGASVP Q9DEF4_XENLA Q9DEF4_XENLA ------------------------------------------------------------ PTC1_CHICK PTC1_CHICK E-VREGLRPPPYRPRRDAFEISTE--GHSGPSNKDRLNHK-AHSHNMRSPAFGAMGVPGS Q5VZC2_HUMAN Q5VZC2_HUMAN DPPREGLWPPPYRPRRDAFEISTE--GHSGPSNRARWGPRGARSHNPRNPASTAMGSSVP PTC1_HUMAN PTC1_HUMAN DPPREGLWPPPYRPRRDAFEISTE--GHSGPSNRARWGPRGARSHNPRNPASTAMGSSVP Q6TKP9_HUMAN Q6TKP9_HUMAN ------------------------------------------------------------ Q2MHN4_MERUN Q2MHN4_MERUN EPPREGLRPPPYRPRRDAFEISTE--GHSGPSNRDRSGPRGARSHNPRNPTSTATGSSVP PTC1_MOUSE PTC1_MOUSE DPPREGLRPPPYRPRRDAFEISTE--GHSGPSNRDRSGPRGARSHNPRNPTSTAMGSSVP Q6UY90_RAT Q6UY90_RAT DPPREGLRPPPYRPRRDAFEISTE--GHSGPSNRDRSGPHGARSHNPRNPTSTAMGSSVP Q9Z2A1_RAT Q9Z2A1_RAT ------------------------------------------------------------ PTC2_HUMAN PTC2_HUMAN ------------------------------------------------------------ PTC2_MOUSE PTC2_MOUSE ------------------------------------------------------------ Q4RVD6_TETNG Q4RVD6_TETNG ------------------------------------------------------------ PTC1_DANRE PTC1_DANRE ------------------------------------------------------------ Q90XB9_CHICK Q90XB9_CHICK ------------------------------------------------------------ Q6IRA5_XENLA Q6IRA5_XENLA QEQKDTKEPSGSRMRQQLPTPS----GPTRTNQPQNSWAQHNTRPQGHRTAPPAYCAKMS Q9DEF3_XENLA Q9DEF3_XENLA QEQKDIKEPSGSRMRQQLPTSS----GPTRTNQPQNSRAQHNTRPQGHRTAPPAYCAKMP MATCH CONSENSUS ????????????????????????????????????????????????????????????

B0UXP5_DANRE B0UXP5_DANRE NYCQPITTVTASASVTVAVHS---GVPSQSPAYPSYPSNDSYQTSGDVHNDPHFSDPHVP Q9W6T6_DANRE Q9W6T6_DANRE ------------------------------------------------------------ Q98SW6_XENLA Q98SW6_XENLA AYGQPITTVTASASVTVAVHPS----VCSHSSYGSYPFYSGY----HENDHGHFEDPHVP Q9DEF4_XENLA Q9DEF4_XENLA ------------------------------------------------------------ PTC1_CHICK PTC1_CHICK AYCQPITTVTASASVTVAVHPA---VHSHNSCRGSFPSCEEY----NEDDRGMFEDPHVP Q5VZC2_HUMAN Q5VZC2_HUMAN GYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPG---Y----PETDHGLFEDPHVP PTC1_HUMAN PTC1_HUMAN GYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPG---Y----PETDHGLFEDPHVP Q6TKP9_HUMAN Q6TKP9_HUMAN ------------------------------------------------------------ Q2MHN4_MERUN Q2MHN4_MERUN SYRQPITTVTASASVTVAVHPP--PGPGRNPRGGPYPGYESY----PETDHGVFEDPHVP PTC1_MOUSE PTC1_MOUSE SYCQPITTVTASASVTVAVHPP--PGPGRNPRGGPCPGYESY----PETDHGVFEDPHVP Q6UY90_RAT Q6UY90_RAT SYCQPITTVTASASVTVAVHPP--PGPGRNPRGGPCPGYESY----PETDHGVFEDPHVP Q9Z2A1_RAT Q9Z2A1_RAT ------------------------------------------------------------ PTC2_HUMAN PTC2_HUMAN ----------VTTSMTVAIHPPPLPGAYIHPAPDEPPWSPAA------------------ PTC2_MOUSE PTC2_MOUSE --------ARVTTSMTVALHPPPLPGAYVHPASEEPT----------------------- Q4RVD6_TETNG Q4RVD6_TETNG ------------------------------------------------------------ PTC1_DANRE PTC1_DANRE ------------------------------------------------------------ Q90XB9_CHICK Q90XB9_CHICK ------------------------------------------------------------ Q6IRA5_XENLA Q6IRA5_XENLA GPNGSITTVTATASVTVAVHPSLPGTVRGYNHEGFEDSDIDCMAIRPE------------ Q9DEF3_XENLA Q9DEF3_XENLA GHNGSITTVTATASVTVAVHPSLPGTAHGYSHEGFEDSDIDCMAIRPE------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

B0UXP5_DANRE B0UXP5_DANRE FDESHD--SSKVEGMELQDLEYDTANVCHTRPSS Q9W6T6_DANRE Q9W6T6_DANRE ---------------------------------- Q98SW6_XENLA Q98SW6_XENLA INVRYERRDSKVEVIELQDVECEERTQGNASK-- Q9DEF4_XENLA Q9DEF4_XENLA ---------------------------------- PTC1_CHICK PTC1_CHICK FNVRCERRNSKVEVIELQDVECEERTAGKISE-- Q5VZC2_HUMAN Q5VZC2_HUMAN FHVRCERRDSKVEVIELQDVECEERPRGSSSN-- PTC1_HUMAN PTC1_HUMAN FHVRCERRDSKVEVIELQDVECEERPRGSSSN-- Q6TKP9_HUMAN Q6TKP9_HUMAN ---------------------------------- Q2MHN4_MERUN Q2MHN4_MERUN FHVRCERRGSKVEVIELQDVECEERPWGSSSN-- PTC1_MOUSE PTC1_MOUSE FHVRCERRDSKVEVIELQDVECEERPWGSSSN-- Q6UY90_RAT Q6UY90_RAT FHVRCERRDSKVEVIELQDVECEERPWGSSSN-- Q9Z2A1_RAT Q9Z2A1_RAT ---------------------------------- PTC2_HUMAN PTC2_HUMAN ----------------TSSGNLSSRGPGPATG-- PTC2_MOUSE PTC2_MOUSE ---------------------------------- Q4RVD6_TETNG Q4RVD6_TETNG ---------------------------------- PTC1_DANRE PTC1_DANRE ---------------------------------- Q90XB9_CHICK Q90XB9_CHICK ---------------------------------- Q6IRA5_XENLA Q6IRA5_XENLA ---WAKRRVKHPEVFELEDLEQDRRQDDLSVQH- Q9DEF3_XENLA Q9DEF3_XENLA ---WAKRRVKHPEVFELEDLEQDRRQDDASVRH- MATCH CONSENSUS ??????????????????????????????????


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