Alignment of the gene Family HBG004961 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
Q4SQ17_TETNG Q4SQ17_TETNG AAEDLPSEFDVVILGTGLAESVAAAAFSRVGQRVLHVDRRSYYAANWASFTFNGLLNWIE Q4V9Q9_DANRE Q4V9Q9_DANRE AAEDLPSQFDVVILGTGLTESVIAAACSRVGQSVLHLDRRNYYAGNWASFTFNGLLSWIE Q6RFG0_DANRE Q6RFG0_DANRE AAEDLPSQFDVVILGTGLTESVIAAACSRVGQSVLHLDRRNYYAGNWASFTFNGLLSWIE A8KBQ8_DANRE A8KBQ8_DANRE AAEDLPSQFDVVILGTGLTESVIAAACSRVGQSVLHLDRRNYYAGNWASFTFNGLLSWIE Q6AZH3_XENLA Q6AZH3_XENLA --DDLPTVFDVVILGTGLPETIIAAACTRTGQRVLHVDARNYYGGNWASFTFSGLQTWIE Q6P7I1_XENLA Q6P7I1_XENLA MADDLPTEFDVVILGTGLPESIIAAACTRTGQQVLHVDARNYYGGNWASFTFSGLQTWIE Q5ZKN6_CHICK Q5ZKN6_CHICK MADNLPSEFDVVVIGTGLPESIIAAACARSGQRVLHVDSRNYYGGNWASFSFSGLLSWIK RAE1_HUMAN RAE1_HUMAN MADTLPSEFDVIVIGTGLPESIIAAACSRSGRRVLHVDSRSYYGGNWASFSFSGLLSWLK A8K545_HUMAN A8K545_HUMAN MADTLPSEFDVIVIGTGLPESIIAAACSRSGRRVLHVDSRSYYGGNWASFSFSGLLSWLK B4DRL9_HUMAN B4DRL9_HUMAN ------------------------------------------------------------ RAE1_RAT RAE1_RAT MADNLPSDFDVIVIGTGLPESIIAAACSRSGQRVLHVDSRSYYGGNWASFSFSGLLSWLK RAE1_MOUSE RAE1_MOUSE MADNLPSDFDVIVIGTGLPESIIAAACSRSGQRVLHVDSRSYYGGNWASFSFSGLLSWLK Q8CBI2_MOUSE Q8CBI2_MOUSE MADNLPSDFDVIVIGTGLPESIIAAACSRSGQRVLHVDSRSYYGGNWASFSFSGLLSWLK A2AD03_MOUSE A2AD03_MOUSE MADNLPSDFDVIVIGTGLPESIIAAACSRSGQRVLHVDSRSYYGGNWASFSFSGLLSWLK Q3UR39_MOUSE Q3UR39_MOUSE MADNLPSDFDVIVIGTGLPESIIAAACSRSGQRVLHVDSRSYYGGNWASFSFSGLLSWLK RAE2_HUMAN RAE2_HUMAN MADNLPTEFDVVIIGTGLPESILAAACSRSGQRVLHIDSRSYYGGNWASFSFSGLLSWLK RAE2_MOUSE RAE2_MOUSE MAEKLPTEFDVVIIGTGLPESILAAACSRSGQRVLHVDSRSYYGGNWASFSFTGLQSWLK MATCH CONSENSUS ?A??LP??FDV???GTGL?ES??AAAC?R?GQ?VLH?D?R?YY?GNWASF?F?GL??W??

Q4SQ17_TETNG Q4SQ17_TETNG QYHEEDP---PDEPRDWSSLLEEGEELIYLSNPDSASIKNLQVFCFTSEEEEEEEEASSS Q4V9Q9_DANRE Q4V9Q9_DANRE EYKNQQELQITESEQEWRSLIEDGEEAVPLNSVDS-SISNLEVFCYASEEEEQEEETKDL Q6RFG0_DANRE Q6RFG0_DANRE EYKNQQELQITESEQEWRSLIEDGEEAVPLNSVDS-SISNLEVFCYASEEEEQEEETKDL A8KBQ8_DANRE A8KBQ8_DANRE EYKNQQELQITESEQEWRSLIEDGEEAVPLNSVDS-SISNLEVFCYASEEEEQEEETKDL Q6AZH3_XENLA Q6AZH3_XENLA NCKQETNTDLAESC---QGQALDNEEIIPFNKRNQ-TIQNVEFFCYSSTEDGENVEEAGA Q6P7I1_XENLA Q6P7I1_XENLA NCKQEPNTDFAESC---KGQALDNEEIIPFNKRNQ-TIQNVEVFCYSSTEDGENIEEAGV Q5ZKN6_CHICK Q5ZKN6_CHICK ENQQNTDIK-DECE-DWRKLILENEEVISLNKKDK-TIQHVEAFCFDDQDAAEDVEEAGA RAE1_HUMAN RAE1_HUMAN EYQENSDIV-SDSP-VWQDQILENEEAIALSRKDK-TIQHVEVFCYASQDLHEDVEEAGA A8K545_HUMAN A8K545_HUMAN EYQENSDIV-SDSP-VWQDQILENEEAIALCRKDK-TIQHVEVFCYASQDLHEDVEEAGA B4DRL9_HUMAN B4DRL9_HUMAN ------------------------------------------------------------ RAE1_RAT RAE1_RAT EYQENNDVV-TENS-MWQEQILENEEAIPLSSKDK-TIQHVEVFCYASQDLHKDVEEAGA RAE1_MOUSE RAE1_MOUSE EYQENSDVV-TENS-MWQEQILENEEAILLSSKDK-TIQHVEVFCYASQDLHKDVEEAGA Q8CBI2_MOUSE Q8CBI2_MOUSE EYQENSDVV-TENS-MWQEQILENEEAILLSSKDK-TIQHVEVFCYASQDLHKDVEEAGA A2AD03_MOUSE A2AD03_MOUSE EYQENSDVV-TENS-MWQEQILENEEAILLSSKDK-TIQHVEVFCYASQDLHKDVEEAGA Q3UR39_MOUSE Q3UR39_MOUSE EYQENSDVV-TENS-MWQEQILENEEAILLSSKDK-TIQHVEVFCYASQDLHKDVEEAGA RAE2_HUMAN RAE2_HUMAN EYQQNNDIG-EESTVVWQDLIHETEEAITLRKKDE-TIQHTEAFCYASQDMEDNVEEIGA RAE2_MOUSE RAE2_MOUSE DYQQNHDSE-EGVTATWQDLIHETEEAISLRKKDE-TIQHTEVFCYASQDVEDSVQDTET MATCH CONSENSUS ????????????????W???????EE???L???D???I???E?FCY?S???????E????

Q4SQ17_TETNG Q4SQ17_TETNG TP-PNTADEDAVKESSETESAGSQ--------------------------------EEET Q4V9Q9_DANRE Q4V9Q9_DANRE LTCPNAETVSEETNSDSTETQDTV-------------------TSDDVTESNVKVQNEEN Q6RFG0_DANRE Q6RFG0_DANRE LTCPNAETVSEETNSDSTETQDTV-------------------TSDDVTESNVKVQNEEN A8KBQ8_DANRE A8KBQ8_DANRE LTCPNAETVSEETNSDSTETQDTV-------------------TSDDVTESNVKVQNEEN Q6AZH3_XENLA Q6AZH3_XENLA LN-INPALLITATTAADSETKTAL--------------------QENTSTEISQ--NHTS Q6P7I1_XENLA Q6P7I1_XENLA LN-LNPALLTTVTTSADSESA----------------------SQENASIDICK--NYKS Q5ZKN6_CHICK Q5ZKN6_CHICK LA-RLPAYGASVAEEVAEEPE------------------KECSPLESAVPGAENLESEKA RAE1_HUMAN RAE1_HUMAN LQ-KNHALVTSANSTEAADSA------------------FLPTEDESLSTMSCEMLTEQT A8K545_HUMAN A8K545_HUMAN LQ-KNHALVTSANSTEAADSA------------------FLPTEDESLSTMSCEMLTEQT B4DRL9_HUMAN B4DRL9_HUMAN --------------------------------------------------MSCEMLTEQT RAE1_RAT RAE1_RAT LQ-KNHASVTSAQSAEAAEAAETS---------------CLPTAVEPLSMGSCEIPAEQS RAE1_MOUSE RAE1_MOUSE LQ-KNPASVMSAQATEAAEAAEAAEATEAAEAAEAAEAACLPTAEESLSTRSCELPAEQS Q8CBI2_MOUSE Q8CBI2_MOUSE LQ-KNPASVMSAQATEAAEAAEAA---EAAEATEAAEAACLPTAEESLSTRSCELPAEQS A2AD03_MOUSE A2AD03_MOUSE LQ-KNPASVMSAQATEAAEAAEAA---EAAEATEAAEAACLPTAEESLSTRSCELPAEQS Q3UR39_MOUSE Q3UR39_MOUSE LQ-KNPASVMSAQATEAAEAAEAA---EAAEATEAAEAACLPTAEESLSTRSCELPAEQS RAE2_HUMAN RAE2_HUMAN LQ-KNPSLGVSNTFTEVLDSA-------------------LPEESQLSYFNSDEMPAKHT RAE2_MOUSE RAE2_MOUSE LQ-RSSPLEASATPADSLDSA------------------SLPKERQSAYSTSYEVPSRHT MATCH CONSENSUS L???N???????????????????????????????????????????????????????

Q4SQ17_TETNG Q4SQ17_TETNG QERGEEEEPKEVS-------------------------KEEEEEPEADQSQPQPAKKKIS Q4V9Q9_DANRE Q4V9Q9_DANRE EDSAPKEQLHASDISEHSQS------------------VEEKQPNRSPADPPAELQKKIT Q6RFG0_DANRE Q6RFG0_DANRE EDSAPKEQLHASDISEHSQS------------------VEEKQPNRSPADPPAELQKKIT A8KBQ8_DANRE A8KBQ8_DANRE EDSAPKEQLHASDISEHSQS------------------VEEKQPNRSPADPPAELQNKIT Q6AZH3_XENLA Q6AZH3_XENLA TVTEKHDNPKESDLEEAASSDQRSANSTLET------GATIEVEPSPAQVNEKDLAKTVT Q6P7I1_XENLA Q6P7I1_XENLA TETEKHDSPEGRSDLEEAASHDQGSADSTPE-----TGATEEVEPFPTQANQQDSPKTVT Q5ZKN6_CHICK Q5ZKN6_CHICK TSVDPASAAEGNVTEINAESESSHDSASGESTLE--SGKTEAALSEI--SAQEPKK--IT RAE1_HUMAN RAE1_HUMAN PSSDPENALEVNGAEVTGEKENHCDDKTCVPSTS--AEDMSENVPIAEDTTEQPKKNRIT A8K545_HUMAN A8K545_HUMAN PSSDPENALEVNGAEVTGEKENHCDDKTCVPSTS--AEDMSENVPIAEDTTEQPKKNRIT B4DRL9_HUMAN B4DRL9_HUMAN PSSDPENALEVNGAEVTGEKENHCDDKTCVPSTS--AEDMSENVPIAEDTTEQPKKNRIT RAE1_RAT RAE1_RAT QCPGPESSPEVNDAEATGKKEN-SDAKSSTE-------EPSENVPKVQDNTETPKKNRIT RAE1_MOUSE RAE1_MOUSE QCMGPESSPQVNDAEV-GEKETQSDAKSSTE-------QSSEILPKVQDNTETPKRNVIT Q8CBI2_MOUSE Q8CBI2_MOUSE QCTGPESSPQVNDAEV-GEKETQSDAKSSTE-------QSSEILPKVQDNTETPKRNVIT A2AD03_MOUSE A2AD03_MOUSE QCTGPESSPQVNDAEV-GEKETQSDAKSSTE-------QSSEILPKVQDNTETPKRNVIT Q3UR39_MOUSE Q3UR39_MOUSE QCTGPESSPQVNDAEV-GEKETQSDAKSSTE-------QSSEILPKVQDNTETPKRNVIT RAE2_HUMAN RAE2_HUMAN QKSDTEISLEVTDVEESVEKEKYCGDKTCMHTVSDKDGDKDESKSTVEDKADEPIRNRIT RAE2_MOUSE RAE2_MOUSE EESDRELSLPSANVEDSLEKEKYCGDKTDMHTVS--GEDKGEHKLVVQDSIEQPKRNRIT MATCH :: CONSENSUS ??????????????????????????????????????????????????????????IT

Q4SQ17_TETNG Q4SQ17_TETNG YAQLVKEGRRFNIDLVSKLMYSRGSLVDLLIKSNVSRYAEFKNVSRILTYRQGRVEPVPC Q4V9Q9_DANRE Q4V9Q9_DANRE YQKLLKEGRRFNIDLVSKLMYSRGALVDLLIKSNVSRYAEFKNIGRILTCRNGKVEQVPC Q6RFG0_DANRE Q6RFG0_DANRE YQKLLKEGRRFNIDLVSKLMYSRGALVDLLIKSNVSRYAEFKNIGRILTCRNGKVEQVPC A8KBQ8_DANRE A8KBQ8_DANRE YQKLLKEGRRFNIDLVSKLMYSRGALVDLLIKSNVSRYAEFKNIGRILTCRNGKVEQVPC Q6AZH3_XENLA Q6AZH3_XENLA YSQIVKEGRRFNIDLVAKFLYSRGLLIELLIKSNVSRYTEFKNVTRILTYHDGKIEQVPC Q6P7I1_XENLA Q6P7I1_XENLA YSQIVKEGRRFNIDLVSKFLYSRGLLIELLIKSNVSRYTEFKNVTRILTYHDGKIEQVPC Q5ZKN6_CHICK Q5ZKN6_CHICK YSQIVREGRRFNIDLVSKLLYSRGLLIELLIKSNVSRYAEFKNATRILAFREGKVEQVPC RAE1_HUMAN RAE1_HUMAN YSQIIKEGRRFNIDLVSKLLYSRGLLIDLLIKSNVSRYAEFKNITRILAFREGRVEQVPC A8K545_HUMAN A8K545_HUMAN YSQIIKEGRRFNIDLVSKLLYSRGLLIDLLIKSNVSRYAEFKNITRILAFREGRVEQVPC B4DRL9_HUMAN B4DRL9_HUMAN YSQIIKEGRRFNIDLVSKLLYSRGLLIDLLIKSNVSRYAEFKNITRILAFREGRVEQVPC RAE1_RAT RAE1_RAT YSQIIKEGRRFNIDLVSQLLYSRGLLIDLLIKSNVSRYAEFKNITRILAFREGTVEQVPC RAE1_MOUSE RAE1_MOUSE YSQIIKEGRRFNIDLVSKLLYSRGLLIDLLIKSNVSRYAEFKNITRILAFREGTVEQVPC Q8CBI2_MOUSE Q8CBI2_MOUSE YSQIIKEGRRFNIDLVSKLLYSRGLLIDLLIKSNVSRYAEFKNITRILAFREGTVEQVPC A2AD03_MOUSE A2AD03_MOUSE YSQIIKEGRRFNIDLVSKLLYSRGLLIDLLIKSNVSRYAEFKNITRILAFREGTVEQVPC Q3UR39_MOUSE Q3UR39_MOUSE YSQIIKEGRRFNIDLVSK---------------------------------------VPC RAE2_HUMAN RAE2_HUMAN YSQIVKEGRRFNIDLVSKLLYSQGLLIDLLIKSDVSRYVEFKNVTRILAFREGKVEQVPC RAE2_MOUSE RAE2_MOUSE YSQMVKESRRFNIDLVSKPLYSQGSLIDLLIKSNVSRYAEFKNVTRILAFWEGKVEQVPC MATCH * ::::*.********:: *** CONSENSUS Y?Q??KEGRRFNIDLVSK??YSRG?L??LLIKSNVSRY?EFKN??RIL????G?VEQVPC

Q4SQ17_TETNG Q4SQ17_TETNG SRADVFASRQLSVVEKRKLMRFLTSCME---ETEEQKAYDGRPYSQFLREQQLGDNLQYF Q4V9Q9_DANRE Q4V9Q9_DANRE SRADVFASKQLTVVEKRMLMKFLTFCLDFEQHPEEYQDYSEKPFSEFLKNKKLTENLQDF Q6RFG0_DANRE Q6RFG0_DANRE SRADVFASKQLTVVEKRMLMKFLTFCLDFEQHPEEYQDYSEKPFSEFLKNKKLTENLQDF A8KBQ8_DANRE A8KBQ8_DANRE SRADVFASKQLTVVEKRMLMKFLTFCLDFEQHPEEYQDYSEKPFSEFLKNKKLTENLQDF Q6AZH3_XENLA Q6AZH3_XENLA SRADVFASKQLSMVEKRILMKFLMHYVDYELHPEDYQDYENSTFLEFLKSKQLTPTLQHF Q6P7I1_XENLA Q6P7I1_XENLA SRADVFASKQLSMVEKRILMKFLMHYVDYELHPEDYQDYEASTFLEFLKSKQLTPTLQHF Q5ZKN6_CHICK Q5ZKN6_CHICK SRADVFNSRQLAMVEKRMLMKFLTFCLEYEQHPDEYQDYKNSTFAQFLKTRKLTPSLQHF RAE1_HUMAN RAE1_HUMAN SRADVFNSKQLTMVEKRMLMKFLTFCMEYEKYPDEYKGYEEITFYEYLKTQKLTPNLQYI A8K545_HUMAN A8K545_HUMAN SRADVFNSKQLTMVEKRMLMKFLTFCMEYEKYPDEYKGYEEITFYEYLKTQKLTPNLQYI B4DRL9_HUMAN B4DRL9_HUMAN SRADVFNSKQLTMVEKRMLMKFLTFCMEYEKYPDEYKGYEEITFYEYLKTQKLTPNLQYI RAE1_RAT RAE1_RAT SRADVFNSKQLTMVEKRMLMKFLTFCVEYEEHPDEYRAYEGTTFSEYLKTQKLTPNLQYF RAE1_MOUSE RAE1_MOUSE SRADVFNSKQLTMVEKRMLMKFLTFCVEYEDHPDEYKAYEETTFSEYLKTQKLTPNLQYF Q8CBI2_MOUSE Q8CBI2_MOUSE SRADVFNSKQLTMVEKRMLMKFHTFCVEYEDHPDEYKAYEETTFSEYLKTQKLTPNLQYF A2AD03_MOUSE A2AD03_MOUSE SRADVFNSKQLTMVEKRMLMKFLTFCVEYEDHPDEYKAYEETTFSEYLKTQKLTPNLQYF Q3UR39_MOUSE Q3UR39_MOUSE SRADVFNSKQLTMVEKRMLMKFLTFCVEYEDHPDEYKAYEETTFSEYLKTQKLTPNLQYF RAE2_HUMAN RAE2_HUMAN SRADVFNSKELTMVEKRMLMKFLTFCLEYEQHPDEYQAFRQCSFSEYLKTKKLTPNLQHF RAE2_MOUSE RAE2_MOUSE SRADVFNSKELSMVEKRMLMKFLTFCLDYEQHSDEYQDFKQCSFSDYLKTKKLTPNLQHF MATCH ****** *::*::**** **:* :: .:: : : .: ::*: ::* .** : CONSENSUS SRADVF?SKQL??VEKRMLMKFLTFC???E??P?EY??Y????F?E?LK??KLT?NLQ?F

Q4SQ17_TETNG Q4SQ17_TETNG ILYSIAMVTEDT-PAEEGLACTRNFLQCLGRYGNTPFLFPVYGLGEIPQCFCRMCAVFGG Q4V9Q9_DANRE Q4V9Q9_DANRE VLLSIAMVTQQT-LTEEGLKATQHFLRCLGRYGNTPFLFPLYGLGEIPQCFCRMCAVFGG Q6RFG0_DANRE Q6RFG0_DANRE VLLSIAMVTQQT-LTEEGLKATQHFLRCLGRYGNTPFLFPLYGLGEIPQCFCRMCAVFGG A8KBQ8_DANRE A8KBQ8_DANRE VLLSIAMVTQQT-LTEEGLKATQHFLRCLGRYGNTPFLFPLYGLGEIPQCFCRMCAVFGG Q6AZH3_XENLA Q6AZH3_XENLA VLYSIAMVPESA-KTVEGLKAMQHFLKCLGRYGNTPFLFPMYGLGEIPQCFCRMCAVFGG Q6P7I1_XENLA Q6P7I1_XENLA VLYSIAMVPESA-KTVEGLKAMQHFLRCLGRYGNTPFLFPMYGLGEIPQCFCRMCAVFGG Q5ZKN6_CHICK Q5ZKN6_CHICK ILHSIAMVSEKDCNTLEGLQATRKFLQCLGRYGNTPFLFPLYGQGEIPQCFCRMCAVFGG RAE1_HUMAN RAE1_HUMAN VMHSIAMTSETASSTIDGLKATKNFLHCLGRYGNTPFLFPLYGQGELPQCFCRMCAVFGG A8K545_HUMAN A8K545_HUMAN VMHSIAMTSETASSTIDGLKATKNFLHCLGRYGNTPFLFPLYGQGELPQCFCRMCAVFGG B4DRL9_HUMAN B4DRL9_HUMAN VMHSIAMTSETASSTIDGLKATKNFLHCLGRYGNTPFLFPLYGQGELPQCFCRMCAVFGG RAE1_RAT RAE1_RAT VLHSIAMTSETTSCTVDGLKATKKFLQCLGRYGNTPFLFPLYGQGELPQCFCRMCAVFGG RAE1_MOUSE RAE1_MOUSE VLHSIAMTSETTSSTVDGLKATKKFLQCLGRYGNTPFLFPLYGQGELPQCFCRMCAVFGG Q8CBI2_MOUSE Q8CBI2_MOUSE VLHSIAMTSETTSSTVDGLKATKKFLQCLGRYGNTPFLFPLYGQGELPQCFCRMCAVFGG A2AD03_MOUSE A2AD03_MOUSE VLHSIAMTSETTSSTVDGLKATKKFLQCLGRYGNTPFLFPLYGQGELPQCFCRMCAVFGG Q3UR39_MOUSE Q3UR39_MOUSE VLHSIAMTSETTSSTVDGLKATKKFLQCLGRYGNTPFLFPLYGQGELPQCFCRMCAVFGG RAE2_HUMAN RAE2_HUMAN VLHSIAMTSESSCTTIDGLNATKNFLQCLGRFGNTPFLFPLYGQGEIPQGFCRMCAVFGG RAE2_MOUSE RAE2_MOUSE ILHSIAMTSESSCTTLDGLQATKNFLQCLGRFGNTPFIFPLYGHGEIPQCFCRMCAVFGG MATCH :: ****..: : :** . ::**:****:*****:**:** **:** ********** CONSENSUS VL?SIAM??E????T??GL?AT??FL?CLGRYGNTPFLFPLYG?GE?PQCFCRMCAVFGG

Q4SQ17_TETNG Q4SQ17_TETNG IYCLRHSVSCLLVDKDTNRCKAVIDSRGQRISCGHLVVEEGYVGAELKRAATPTRFVSRA Q4V9Q9_DANRE Q4V9Q9_DANRE IYCLRHSVQCLVVDKESNKVKAVIDTRGQKIGCSHFVVEDSYI-REEQRESINYRQISRA Q6RFG0_DANRE Q6RFG0_DANRE IYCLRHSVQCLVVDKESNKVKAVIDTRGQKIGCSHFVVEDSYI-REEQRESIDYRQISRA A8KBQ8_DANRE A8KBQ8_DANRE IYCLRHSVQCLVVDKESNKVKAVIDTRGQKIGCSHFVVEDSYI-REEQRESIDYRQISRA Q6AZH3_XENLA Q6AZH3_XENLA VYCLHHSLECLVVDEDSKLCKAVIDHRGKRVDCKYLVVEDSYL-PEQICANVSYKQISRA Q6P7I1_XENLA Q6P7I1_XENLA VYCLHHSLECLVVDGDSKLCKAVIDHRGKRVDCKYLVVEDSYL-PEQICANVSYKQISRA Q5ZKN6_CHICK Q5ZKN6_CHICK IYCLRHSVQCLVVDKESGRCKAVVDHFGQRISANYFIVEDSYL-SESVCENVCYRQLSRA RAE1_HUMAN RAE1_HUMAN IYCLRHSVQCLVVDKESRKCKAIIDQFGQRIISEHFLVEDSYF-PENMCSRVQYRQISRA A8K545_HUMAN A8K545_HUMAN IYCLRHSVQCLVVDKESRKCKAIIDQFGQRIISEHFLVEDSYF-PENMCSRVQYRQISRA B4DRL9_HUMAN B4DRL9_HUMAN IYCLRHSVQCLVVDKESRKCKAIIDQFGQRIISEHFLVEDSYF-PENMCSRVQYRQISRA RAE1_RAT RAE1_RAT IYCLRHSVQCLVVDKESRKCKAVIDQFGQRIISKHFIIEDSYL-SENTCSRVQYRQISRA RAE1_MOUSE RAE1_MOUSE IYCLRHSVQCLVVDKESRKCKAIVDQFGQRIISKHFVIEDSYL-SENTCSGVQYRQISRA Q8CBI2_MOUSE Q8CBI2_MOUSE IYCLRHSVQCLVVDKESRKCKAIVDQFGQRIISKHFVIEDSYL-SENTCSGVQYRQISRA A2AD03_MOUSE A2AD03_MOUSE IYCLRHSVQCLVVDKESRKCKAIVDQFGQRIISKHFVIEDSYL-SENTCSGVQYRQISRA Q3UR39_MOUSE Q3UR39_MOUSE IYCLRHSVQCLVVDKESRKCKAIVDQFGQRIISKHFVIEDSYL-SENTCSGVQYRQISRA RAE2_HUMAN RAE2_HUMAN IYCLRHKVQCFVVDKESGRCKAIIDHFGQRINAKYFIVEDSYL-SEETCSNVQYKQISRA RAE2_MOUSE RAE2_MOUSE VYCLRHKVQCLVVDKDSGRCKGIIDAFGQRISANYFIVEDSYL-PKETCSNVQYKQISRA MATCH :***:*.:.*::** :: *.::* *::: . ::::*:.*. : : :*** CONSENSUS IYCLRHSVQCLVVDK?S??CKA??D??GQRI????F??EDSY???E???????Y?QISRA

Q4SQ17_TETNG Q4SQ17_TETNG VLITDGSVLPSSSDQQVSLVTIPPITAGCAAVRMVELSPSTMTCMPGTYLVHLTCQSSG- Q4V9Q9_DANRE Q4V9Q9_DANRE VLITDRSVLPSESDQQISLVTVPPVESSGPAVRMVELCSSSMTCMPGTCLVHLTCSSSG- Q6RFG0_DANRE Q6RFG0_DANRE VLITDRSVLPSESDQQISLVTVPPVESSGPAVRMVELCSSSMTCMPGTCLVHLTCSSSG- A8KBQ8_DANRE A8KBQ8_DANRE VLITDRSVLPSESDQQISLVTVPPVESSGPAVRMVELCSSSMTCMPGTCLVHLTCSSSG- Q6AZH3_XENLA Q6AZH3_XENLA VLITDCSILNSESNQEISVLTFPPSDKGQNAVYLTELCSSTMTCMKNTYLVHLTCSSTKA Q6P7I1_XENLA Q6P7I1_XENLA VLITDCSILNSESNQEISVLTFPPAD-GQNAVYLTELCSSTMTCMKNTYVVHLTCSSTKA Q5ZKN6_CHICK Q5ZKN6_CHICK VLITDQSVLKTDSEQQVSILMVPPVDLGQPAVCVIELCSSTMTCMKDTYLVHLTCPSTK- RAE1_HUMAN RAE1_HUMAN VLITDRSVLKTDSDQQISILTVPAEEPGTFAVRVIELCSSTMTCMKGTYLVHLTCTSSK- A8K545_HUMAN A8K545_HUMAN VLITDRSVLKTDSDQQISILTVPAEEPGTFAVRVIELCSSTMTCMKGTYLVHLTCTSSK- B4DRL9_HUMAN B4DRL9_HUMAN VLITDRSVLKTDSDQQISILTVPAEEPGTFAVRVIELCSSTMTCMKGTYLVHLTCTSSK- RAE1_RAT RAE1_RAT VLITDGSVLKTDADQQVSILAVPAEEPGSFGVRVIELCSSTMTCMKGTYLVHLTCMSSK- RAE1_MOUSE RAE1_MOUSE VLITDGSVLKPDSDQQVSILTVPAEESGSFAVRVIELCSSTMTCMKGTYLVHLTCMSSK- Q8CBI2_MOUSE Q8CBI2_MOUSE VLITDGSVLKPDSDQQVSILTVPAEESGSFAVRVIELCSSTMTCMKGT------------ A2AD03_MOUSE A2AD03_MOUSE VLITDGSVLKPDSDQQVSILTVPAEESGSFAVRVIELCSSTMTCMKGTYLVHLTCMSSK- Q3UR39_MOUSE Q3UR39_MOUSE VLITDGSVLKPDSDQQVSILTVPAEESGSFAVRVIELCSSTMTCMKGTYLVHLTCMSSK- RAE2_HUMAN RAE2_HUMAN VLITDQSILKTDLDQQTSILIVPPAEPGACAVRVTELCSSTMTCMKDTYLVHLTCSSSK- RAE2_MOUSE RAE2_MOUSE VLITDQSILKTDSDQQISILVVPPLEPGTTSVRVMELCSSTMTCMKDSYLVHLTCSSSK- MATCH ***** *:* .. :*: *:: .*. . .* : **..*:**** .: CONSENSUS VLITD?S?L???SDQQ?S???VP????G??AVR??ELCSSTMTCM??T?LVHLTC?S???

Q4SQ17_TETNG Q4SQ17_TETNG SAYDDLSPLVTRMFCTPDSPDQETVRLSSGASTSTSLMVQGWRPRTQPSLQRVRVLRTRR Q4V9Q9_DANRE Q4V9Q9_DANRE TAQQDLAPVVSQLFHIPTTPGED------------------------------------- Q6RFG0_DANRE Q6RFG0_DANRE TAQQDLAPVVSQLFHIPTTPGED------------------------------------- A8KBQ8_DANRE A8KBQ8_DANRE TAQQDLAPVVSQLFHIPTTPGED------------------------------------- Q6AZH3_XENLA Q6AZH3_XENLA SAKEDLEPVVQQLFT----LSTE------------------------------------- Q6P7I1_XENLA Q6P7I1_XENLA TAKEDLEPVVQQLFT----LSTE------------------------------------- Q5ZKN6_CHICK Q5ZKN6_CHICK TAREDLEPVVQKLFSLN--AETE------------------------------------- RAE1_HUMAN RAE1_HUMAN TAREDLESVVQKLFV----PYTE------------------------------------- A8K545_HUMAN A8K545_HUMAN TAREDLESVVQKLFV----PYTE------------------------------------- B4DRL9_HUMAN B4DRL9_HUMAN TAREDLESVVQKLFV----PYTE------------------------------------- RAE1_RAT RAE1_RAT TAREDLERVVQKLFT----PYTE------------------------------------- RAE1_MOUSE RAE1_MOUSE TAREDLERVVQKLFT----PYTE------------------------------------- Q8CBI2_MOUSE Q8CBI2_MOUSE ------------------------------------------------------------ A2AD03_MOUSE A2AD03_MOUSE TAREDLERVVQKLFT----PYTE------------------------------------- Q3UR39_MOUSE Q3UR39_MOUSE TAREDLERVVQKLFT----PYTE------------------------------------- RAE2_HUMAN RAE2_HUMAN TAREDLESVVKKLFT----PYTE------------------------------------- RAE2_MOUSE RAE2_MOUSE TAREDLEPVVKQLFI----PEAE------------------------------------- MATCH CONSENSUS TA??DL??VV??LF??????????????????????????????????????????????

Q4SQ17_TETNG Q4SQ17_TETNG RPGPRERHQADLVHLTCQSSGSAYDDLSPLVTRMFCTPDSPDQGNCPSVLWCLYFNITDG Q4V9Q9_DANRE Q4V9Q9_DANRE ------------------------------------PSEGTGEISKPAVLWVMYFNMRDT Q6RFG0_DANRE Q6RFG0_DANRE ------------------------------------PSEGTGEISKPAVLWVMYFNMRDT A8KBQ8_DANRE A8KBQ8_DANRE ------------------------------------PSEGTGEISKPAVLWVMYFNMRDT Q6AZH3_XENLA Q6AZH3_XENLA ------------------------------------KDLESNDPPKPKVLWALYFNMRDS Q6P7I1_XENLA Q6P7I1_XENLA ------------------------------------KDLETSDITKPKVLWALYFNMRDS Q5ZKN6_CHICK Q5ZKN6_CHICK ------------------------------------KETEDEVLEKPRVLWALYFNMRDS RAE1_HUMAN RAE1_HUMAN ------------------------------------MEIENEQVEKPRILWALYFNMRDS A8K545_HUMAN A8K545_HUMAN ------------------------------------MEIENEQVEKPRILWALYFNMRDS B4DRL9_HUMAN B4DRL9_HUMAN ------------------------------------MEIENEQVEKPRILWALYFNMRDS RAE1_RAT RAE1_RAT ------------------------------------IEAENEQVEKPRLLWALYFNMRDS RAE1_MOUSE RAE1_MOUSE ------------------------------------IEAENEQVEKPRILWALYFNMRDS Q8CBI2_MOUSE Q8CBI2_MOUSE ------------------------------------------------------------ A2AD03_MOUSE A2AD03_MOUSE ------------------------------------IEAENEQVEKPRILWALYFNMRDS Q3UR39_MOUSE Q3UR39_MOUSE ------------------------------------IEAENEQVEKPRILWALYFNMRDS RAE2_HUMAN RAE2_HUMAN ------------------------------------TEINEEELTKPRLLWALYFNMRDS RAE2_MOUSE RAE2_MOUSE ------------------------------------AEAGKDELRKPRLLWALYFNMRDS MATCH CONSENSUS ?????????????????????????????????????????????KP??LW??YFNMRD?

Q4SQ17_TETNG Q4SQ17_TETNG SGLEAQGHN-LPSNVYVCSGPDGALGHENAIKQAESIFSKILPGEDFCPPAPNPEDIIYD Q4V9Q9_DANRE Q4V9Q9_DANRE SAMDSSCYS-LPSNVHVCTGPDAGLGSDYSIKLAESVFHCLLPDEEFCPPAPNPEDIIYD Q6RFG0_DANRE Q6RFG0_DANRE SAMDSSCYS-LPSNVHVCTGPDAGLGSDYSIKLAESVFHCLLPDEEFCPPAPNPEDIIYD A8KBQ8_DANRE A8KBQ8_DANRE SAMDSSCYS-LPSNVHVCTGPDAGLGSDYSIKLAESVFHCLLPDEEFCPPAPNPEDIIYD Q6AZH3_XENLA Q6AZH3_XENLA SGVPRQSYVGLPSNVYVCSGPDHCFGNDNAVQQAEDIFQKLYPSEEFCPPAPNPEDIVYD Q6P7I1_XENLA Q6P7I1_XENLA SGVPRQSYVGLPSNVYVCSGPDHCFGNDHAVQQAENIFHDLYPSEEFCPPAPNPEDIIYD Q5ZKN6_CHICK Q5ZKN6_CHICK SGIDRNSYSGLPSNVYVCSGPDSALGNDCAVKQAETIFQEMFPTEEFCPAPPNPEDIIYD RAE1_HUMAN RAE1_HUMAN SDISRSCYNDLPSNVYVCSGPDCGLGNDNAVKQAETLFQEICPNEDFCPPPPNPEDIILD A8K545_HUMAN A8K545_HUMAN SDISRSCYNDLPSNVYVCSGPDCGLGNDNAVKQAETLFQEICPNEDFCPPPPNPEDIILD B4DRL9_HUMAN B4DRL9_HUMAN SDISRSCYNDLPSNVYVCSGPDCGLGNDNAVKQAETLFQEICPNEDFCPPPPNPEDIILD RAE1_RAT RAE1_RAT SDISRDCYNDLPSNVYVCSGPDSGLGNDNAVKQAETLFQQICPNEDFCPAPPNPEDIVLD RAE1_MOUSE RAE1_MOUSE SDISRDCYNDLPSNVYVCSGPDCNLGNDNAVQQAEIVFQKICPNEDFCPAPPNPEDIILD Q8CBI2_MOUSE Q8CBI2_MOUSE ------------------------------------------------------------ A2AD03_MOUSE A2AD03_MOUSE SDISRDCYNDLPSNVYVCSGPDCNLGNDNAVQQAETVFQKICPNEDFCPAPPNPEDIILD Q3UR39_MOUSE Q3UR39_MOUSE SDISRDCYNDLPSNVYVCSGPDCNLGNDNAVQQAETVFQKICPNEDFCPAPPNPEDIILD RAE2_HUMAN RAE2_HUMAN SGISRSSYNGLPSNVYVCSGPDCGLGNEHAVKQAETLFQEIFPTEEFCPPPPNPEDIIFD RAE2_MOUSE RAE2_MOUSE SGVSRSSYCGLPSNVYICSGPDWGLGSEHAVKQAETLFQEIFPSEEFCPPPPNPEDIIFE MATCH CONSENSUS S??????Y??LPSNV?VC?GPD??LG???????AE??F????P?E?FCP??PNPEDII?D

Q4SQ17_TETNG Q4SQ17_TETNG GD---------------------------------------------------------- Q4V9Q9_DANRE Q4V9Q9_DANRE GDAPQAEGRGFDESNDTEADKSQAE-EEGTTNETNPENSEAAEMDSVAQETTLDTNAPSE Q6RFG0_DANRE Q6RFG0_DANRE GDAPQAEGRGFDESNDTEANKSQAE-EEGTTNETNPENSEAAEMDSVAQETTLDTNPPSE A8KBQ8_DANRE A8KBQ8_DANRE GDAPQAEGPGFDESNDTEANKSQAE-EEGTTNETNPENSEAAEMDSVAQETTLDTNPPSE Q6AZH3_XENLA Q6AZH3_XENLA ADCAQQE-------PIPVDSKAEAS-AEHGTVPNSYEDTEGEKAE--------------- Q6P7I1_XENLA Q6P7I1_XENLA GECVQQEAS---ESSIPVKAEASAETVTESCEDLEGQKAE-------------------- Q5ZKN6_CHICK Q5ZKN6_CHICK EDEIASEET---GFNNSPETKPESSLQESSSRGSSTAVKEHIEE---------------- RAE1_HUMAN RAE1_HUMAN GDSLQPEAS---ESSAIPEANSETF-KESTNLGNLEESSE-------------------- A8K545_HUMAN A8K545_HUMAN GDSLQPEAS---ESSAIPEANSETF-KESTNLGNLEESSE-------------------- B4DRL9_HUMAN B4DRL9_HUMAN GDSLQPEAS---ESSAIPEANSETF-KESTNLGNLEESSE-------------------- RAE1_RAT RAE1_RAT GDSSQQEVP---ESSVTPETNSETP-KESTVLGNPEEPSE-------------------- RAE1_MOUSE RAE1_MOUSE GDSSQQEVS---ESSVIPETNSETP-KESTVLGDSEEPSE-------------------- Q8CBI2_MOUSE Q8CBI2_MOUSE ------------------------------------------------------------ A2AD03_MOUSE A2AD03_MOUSE GDSSQQEVS---ESSVIPETNSETP-KESTVLGDSEEPSE-------------------- Q3UR39_MOUSE Q3UR39_MOUSE GDSSQQEVS---ESSVIPETNSETP-KESTVLGDSEEPSE-------------------- RAE2_HUMAN RAE2_HUMAN GDDKQPEAP---GTNNVVMAKLESS-EESKNLESPEKHLQN------------------- RAE2_MOUSE RAE2_MOUSE AEG--------------------------------------------------------- MATCH CONSENSUS ?D????E?????????????????????????????????????????????????????

Q4SQ17_TETNG Q4SQ17_TETNG - Q4V9Q9_DANRE Q4V9Q9_DANRE E Q6RFG0_DANRE Q6RFG0_DANRE E A8KBQ8_DANRE A8KBQ8_DANRE E Q6AZH3_XENLA Q6AZH3_XENLA - Q6P7I1_XENLA Q6P7I1_XENLA - Q5ZKN6_CHICK Q5ZKN6_CHICK - RAE1_HUMAN RAE1_HUMAN - A8K545_HUMAN A8K545_HUMAN - B4DRL9_HUMAN B4DRL9_HUMAN - RAE1_RAT RAE1_RAT - RAE1_MOUSE RAE1_MOUSE - Q8CBI2_MOUSE Q8CBI2_MOUSE - A2AD03_MOUSE A2AD03_MOUSE - Q3UR39_MOUSE Q3UR39_MOUSE - RAE2_HUMAN RAE2_HUMAN - RAE2_MOUSE RAE2_MOUSE - MATCH CONSENSUS ?


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