Alignment of the gene Family HBG005495 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
DMD_CHICK DMD_CHICK SAHVLWYEEVED----------------DYEREDVQKKTFTKWINAQFAKCGRRCIEDLF A2A9Z0_MOUSE A2A9Z0_MOUSE ---MLWWEEVED----------------CYEREDVQKKTFTKWINAQFSKFGKQHIDNLF DMD_MOUSE DMD_MOUSE ---MLWWEEVED----------------CYEREDVQKKTFTKWINAQFSKFGKQHIDNLF DMD_PIG DMD_PIG ------MSEV-S----------------SDEREDVQKKTFTKWINAQFSKFGKQHIENLF DMD_HUMAN DMD_HUMAN ---MLWWEEVED----------------CYEREDVQKKTFTKWVNAQFSKFGKQHIENLF DMD_CANFA DMD_CANFA ---MLWWEEVED----------------CYEREDVQKKTFTKWVNAQFSKFGKQHIENLF Q4S6Z2_TETNG Q4S6Z2_TETNG -----------------------------DEHDSVQKKTFTKWINAQLSKTGKMPIKDMF O08614_MOUSE O08614_MOUSE ---MAKYGDLEARPDDGQNEFSDIIKSRSDEHNDVQKKTFTKWINARFSKSGKPPISDMF O55147_RAT O55147_RAT ---MAKYGHLEASPDDGQNQFSDIIKSRSDEHNDVQKKTFTKWINARFSKSGKPPINDMF Q5JCF5_CANFA Q5JCF5_CANFA ---MAKYGEHEARPDDGQNEFSDIIKSRSDEHNDVQKKTFTKWINARFSKSGKPPINDMF UTRO_HUMAN UTRO_HUMAN ---MAKYGEHEASPDNGQNEFSDIIKSRSDEHNDVQKKTFTKWINARFSKSGKPPINDMF MATCH *::.*********:**:::* *: *.::* CONSENSUS ??????????E???????????????????E??DVQKKTFTKWINA?FSK?GK??I???F

DMD_CHICK DMD_CHICK NDFRDGRKLLELLECLTGQKIAKEKGSTRVHALNNVNKALQILQRNNVDLVNIGSSDIVD A2A9Z0_MOUSE A2A9Z0_MOUSE SDLQDGKRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQKNNVDLVNIGSTDIVD DMD_MOUSE DMD_MOUSE SDLQDGKRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQKNNVDLVNIGSTDIVD DMD_PIG DMD_PIG NDLQDGRRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALQVLQKNNVDLVNIGSTDIVD DMD_HUMAN DMD_HUMAN SDLQDGRRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQNNNVDLVNIGSTDIVD DMD_CANFA DMD_CANFA SDLQDGRRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQKNNVDLVNIGSTDIVD Q4S6Z2_TETNG Q4S6Z2_TETNG TDLKDGRKLLDLLEGLTGTTLTKERGSTRVHALNNVNKVLQVLHQNNVDLVNIGGTDIVD O08614_MOUSE O08614_MOUSE SDLKDGRKLLDLLEGLTGTSLPKERGSTRVHALNNVNRVLQVLHQNNVDLVNIGGTDIVA O55147_RAT O55147_RAT SDLKDGRKLLDLLEGLTGTSLPKERGSTRVHALNNVNRVLQVLHQNNVELVNIGGTDIVD Q5JCF5_CANFA Q5JCF5_CANFA TDLKDGRKLLDLLEGLTGTSLPKERGSTRVHALNNVNRVLQVLHQNNVDLVNIGGTDIVD UTRO_HUMAN UTRO_HUMAN TDLKDGRKLLDLLEGLTGTSLPKERGSTRVHALNNVNRVLQVLHQNNVELVNIGGTDIVD MATCH .*::**::**:*** *** .:.**:************:.*::*:.***:*****.:*** CONSENSUS ?DL?DGR?LLDLLEGLTG??LPKE?GSTRVHALNNVN??L?VL??NNVDLVNIG?TDIVD

DMD_CHICK DMD_CHICK GNHKLTLGLIWNIILHWQVKDVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTS A2A9Z0_MOUSE A2A9Z0_MOUSE GNHKLTLGLIWNIILHWQVKNVMKTIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTS DMD_MOUSE DMD_MOUSE GNHKLTLGLIWNIILHWQVKNVMKTIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTS DMD_PIG DMD_PIG GNHKLTLGLIWNIILHWQVKNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTT DMD_HUMAN DMD_HUMAN GNHKLTLGLIWNIILHWQVKNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTT DMD_CANFA DMD_CANFA GNHKLTLGLIWNIILHWQVKNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTT Q4S6Z2_TETNG Q4S6Z2_TETNG GNHKLTLGLIWSIILHWQVKDIMKDVMANLQQTNSEKILLSWVRQCTRLYPEVNVLNFTT O08614_MOUSE O08614_MOUSE GNPKLTLGLLWSIILHWQVKDVMKDIMSDLQQTNSEKILLSWVRQTTRPYSQVNVLNFTT O55147_RAT O55147_RAT GNPKLTLGLLWSIILHWQVKDVMKDIMSDLQQTNSEKILLSWVRQTTRPYSQVNVLNFTT Q5JCF5_CANFA Q5JCF5_CANFA GNHKLTLGLLWSIILHWQVKDVMKDVMSDLQQTNSEKILLSWVRQSTRPYSQVNVLNFTT UTRO_HUMAN UTRO_HUMAN GNHKLTLGLLWSIILHWQVKDVMKDVMSDLQQTNSEKILLSWVRQTTRPYSQVNVLNFTT MATCH ** ******:*.********::** :*:.**************** ** *.:***:***: CONSENSUS GNHKLTLGL?W?IILHWQVK?VMK??M??LQQTNSEKILLSWVRQ?TR?Y?QVNV?NFT?

DMD_CHICK DMD_CHICK SWSDGLAFNALLHSHRPDLFDWNAVASQQSPVQRLDHAFNIARQHLGIEKLLDPEDVATA A2A9Z0_MOUSE A2A9Z0_MOUSE SWSDGLALNALIHSHRPDLFDWNSVVSQHSATQRLEHAFNIAKCQLGIEKLLDPEDVATT DMD_MOUSE DMD_MOUSE SWSDGLALNALIHSHRPDLFDWNSVVSQHSATQRLEHAFNIAKCQLGIEKLLDPEDVATT DMD_PIG DMD_PIG SWSDGLALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIAKYQLGIEKLLDPEDVATT DMD_HUMAN DMD_HUMAN SWSDGLALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTT DMD_CANFA DMD_CANFA SWSDGLALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIAKYQLGIEKLLDPEDVATT Q4S6Z2_TETNG Q4S6Z2_TETNG SWTDGLALNGILHHFSHFL----SPSYHHSIYNSFYNHFLHSHSSLH-AIFISISDVVVQ O08614_MOUSE O08614_MOUSE SWTDGLAFNAVLHRHKPDLFDWDEMV-KMSPIERLDHAFDKAHTSLGIEKLLSPETVAVH O55147_RAT O55147_RAT SWTDGLAFNAVLHRHKPDLFSWDRVV-KMSPTERLEHAFSKAHTYLGIEKLLDPEDVAVQ Q5JCF5_CANFA Q5JCF5_CANFA SWTDGLAFNAVLHRHKPDLFSWDRVV-KMSPIERLEHAFSKAQTYLGIEKLLDPEDVAVQ UTRO_HUMAN UTRO_HUMAN SWTDGLAFNAVLHRHKPDLFSWDKVV-KMSPIERLEHAFSKAQTYLGIEKLLDPEDVAVQ MATCH **:****:*.::* . * : * : : : * :: * ::. . * . CONSENSUS SW?DGLA?NA??H?H?PDLF?W??VV???S???RL?HAF??A???LGIEKLLDPEDVA??

DMD_CHICK DMD_CHICK CPDKKSILMYVTSLFQVLPQQVTMEAIREVEMLPRHS-RVTTEEHIQVHHQQHFSQEITV A2A9Z0_MOUSE A2A9Z0_MOUSE YPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRTSSKVTREEHFQLHHQMHYSQQITV DMD_MOUSE DMD_MOUSE YPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRTSSKVTREEHFQLHHQMHYSQQITV DMD_PIG DMD_PIG YPDKKSILMYVTSLFQVLPQQVSIEAIQEVEMLPRPS-KVTREEHFQLHHQMHYSQQITV DMD_HUMAN DMD_HUMAN YPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRPP-KVTKEEHFQLHHQMHYSQQITV DMD_CANFA DMD_CANFA YPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRPS-QVTREEHFQIHHQMHYSQQITV Q4S6Z2_TETNG Q4S6Z2_TETNG LPDKKSIIMYVTSLFAVLPKDVSMEAIREVETLPRRY-KASEDAAVDL------------ O08614_MOUSE O08614_MOUSE LPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEEIHI------------ O55147_RAT O55147_RAT LPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEGEEINI------------ Q5JCF5_CANFA Q5JCF5_CANFA LPDKKSIIMYLTSLFEVHPQQVTLDAIREVETLPRKYKKECEEGEISI------------ UTRO_HUMAN UTRO_HUMAN LPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINI------------ MATCH ******:**:**** * *::*:::**:*** *** : . : CONSENSUS ?PDKKSI?MY?TSLF?VLPQQV???AI?EVE?LPR???K???EE????????????????

DMD_CHICK DMD_CHICK NIPQ---RPSPSPKPRFKSYAYAQTAYVIPPDQKRRQVPPQFLETVEKRTYTTTVMRSEM A2A9Z0_MOUSE A2A9Z0_MOUSE SLAQGYEQTSSSPKPRFKSYAFTQAAYVATSDSTQSPYPSQHLEAPRDKSLDSSLMETEV DMD_MOUSE DMD_MOUSE SLAQGYEQTSSSPKPRFKSYAFTQAAYVATSDSTQSPYPSQHLEAPRDKSLDSSLMETEV DMD_PIG DMD_PIG CLAQGYERTPS-PKPRFKSYAYTQAAYVTTSDPTRSPFPSQRLESPEDKSFGSSLLETEV DMD_HUMAN DMD_HUMAN SLAQGYERTSS-PKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEV DMD_CANFA DMD_CANFA SLAQGYERAPSFPKPRFKSYAYTQAAYVTTSDPTRSPLPSQHLETPEDKSFGRSLTETEA Q4S6Z2_TETNG Q4S6Z2_TETNG ------------------------------------------------------------ O08614_MOUSE O08614_MOUSE ----------------------------------QSAVLAEEGQSPRAET-PSTVTEVDM O55147_RAT O55147_RAT ----------------------------------QSAVLTEEGQSPRAET-PSTVTEVDM Q5JCF5_CANFA Q5JCF5_CANFA ----------------------------------QSSAPEEEHECPGAET-PSTVTEVDT UTRO_HUMAN UTRO_HUMAN ----------------------------------QSTAPEEEHESPRAET-PSTVTEVDM MATCH CONSENSUS ???????????????????????????????????S?????????P??????????E???

DMD_CHICK DMD_CHICK DLDSYQTALEEVLTWLLSAEDALQAQGDISSDVEVVKEQFHTHEGFMMELTAHQGRVGNV A2A9Z0_MOUSE A2A9Z0_MOUSE NLDSYQTALEEVLSWLLSAEDTLRAQGEISNDVEEVKEQFHAHEGFMMDLTSHQGLVGNV DMD_MOUSE DMD_MOUSE NLDSYQTALEEVLSWLLSAEDTLRAQGEISNDVEEVKEQFHAHEGFMMDLTSHQGLVGNV DMD_PIG DMD_PIG NLDSYQTALEEVLSWLLSAEDTLQAQGEISNDVEEVKEQFHTHEGYMMDLTSHQGRIGSV DMD_HUMAN DMD_HUMAN NLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNI DMD_CANFA DMD_CANFA NLDSYQTALEEVLSWLLSAEDALQAQGEISNDVEEVKEQFHTHEGYMMDLTSHQGRVGNV Q4S6Z2_TETNG Q4S6Z2_TETNG ------------------------------------------------------------ O08614_MOUSE O08614_MOUSE DLDSYQIALEEVLTWLLSAEDTFQEQHDISDDVEEVKEQFATHETFMMELTAHQSSVGSV O55147_RAT O55147_RAT DLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEDVKEQFATHETFMMELSAHQSSVGSV Q5JCF5_CANFA Q5JCF5_CANFA DLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKEQFTTHEAFMMELTAHQSSVGSV UTRO_HUMAN UTRO_HUMAN DLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSV MATCH CONSENSUS ?LDSYQ?ALEEVL?WLLSAED????Q??IS?DVE?VK?QF??HE??MM?LT?HQ??VG?V

DMD_CHICK DMD_CHICK LQVGSQLLAMGKLSDDEENEIQEQMNLLNSRWESLRVASMEKQSNLHKILMDLQNQQLAQ A2A9Z0_MOUSE A2A9Z0_MOUSE LQLGSQLVGKGKLSEDEEAEVQEQMNLLNSRWECLRVASMEKQSKLHKVLMDLQNQKLKE DMD_MOUSE DMD_MOUSE LQLGSQLVGKGKLSEDEEAEVQEQMNLLNSRWECLRVASMEKQSKLHKVLMDLQNQKLKE DMD_PIG DMD_PIG LQLGSQLIGKGKLSEDEETEVQEQMNLLNSRWECLRVASVEKQSNLHKVLMDLQNQQLKE DMD_HUMAN DMD_HUMAN LQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKE DMD_CANFA DMD_CANFA LQLGSQLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHKVLMDLQNQQLKE Q4S6Z2_TETNG Q4S6Z2_TETNG ------------------------------------------------------------ O08614_MOUSE O08614_MOUSE LQAGNQLMTQGTLSREEEFEIQEQMTLLNARWEALRVESMERQSRLHDALMELQKKQLQQ O55147_RAT O55147_RAT LQAGNQLMTQGTLSDEEEFEIQEQMTLLNARWEALRVESMERQSRLHDALMELQKKQLQQ Q5JCF5_CANFA Q5JCF5_CANFA LQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVDSMNRQSRLHDVLMELQKKQLQQ UTRO_HUMAN UTRO_HUMAN LQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQ MATCH CONSENSUS LQ?G?QL???G?LS??EE?E?QEQM?LLN?RWE?LRV?SM??QS?LH??LM?LQ???L??

DMD_CHICK DMD_CHICK LADWLTKTEERTKKIDSEPLGPDLEDLKRQVEEHKAFQDDLEQEQVKVNSLTHMVVVVDE A2A9Z0_MOUSE A2A9Z0_MOUSE LDDWLTKTEERTKKMEEEPFGPDLEDLKCQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDE DMD_MOUSE DMD_MOUSE LDDWLTKTEERTKKMEEEPFGPDLEDLKCQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDE DMD_PIG DMD_PIG LNDWLTKTEEKTRKMEKEPLGPDLEDLKHQIQQHKVLQEDLEQEQVRVNSLTHMVVVVDE DMD_HUMAN DMD_HUMAN LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDE DMD_CANFA DMD_CANFA LNDWLTKTEERTRKMEKEPLGPDIEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDE Q4S6Z2_TETNG Q4S6Z2_TETNG --------------------------------STQELQNDLEAEQVKVNSLTHMVVVVDE O08614_MOUSE O08614_MOUSE LSSWLALTEERIQKMESLPLGDDLPSLQKLLQEHKSLQNDLEAEQVKVNSLTHMVVIVDE O55147_RAT O55147_RAT LSGWLTLTEERIQKMESLPVGDDLPSLQNLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDE Q5JCF5_CANFA Q5JCF5_CANFA LSAWLTLTEERIQKMETCPLDDDLKSLQKLLEDHKRLQNDLEAEQVKVNSLTHMVVIVDE UTRO_HUMAN UTRO_HUMAN LSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDE MATCH . : :*.*** ***:*********:*** CONSENSUS L??WLT?TEER??KME??P???D???L??????HK?LQ?DLE?EQV?VNSLTHMVV?VDE

DMD_CHICK DMD_CHICK NSGDKATAALEEQLQHFGSRWAAICRWTEDRWVLLQDILRKWQHFAEEQCLFDAWLTEKE A2A9Z0_MOUSE A2A9Z0_MOUSE SSGDHATAALEEQLKVLGDRWANICRWTEDRWIVLQDILLKWQHFTEEQCLFSTWLSEKE DMD_MOUSE DMD_MOUSE SSGDHATAALEEQLKVLGDRWANICRWTEDRWIVLQDILLKWQHFTEEQCLFSTWLSEKE DMD_PIG DMD_PIG SSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRFTEEQCLFSTWLSEKE DMD_HUMAN DMD_HUMAN SSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKE DMD_CANFA DMD_CANFA SSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRFTEEQCLFSAWLSEKE Q4S6Z2_TETNG Q4S6Z2_TETNG NSGEGATAALEEQLQSLGERWAAVCRWTEERWHKLQEVFVVWQQLLSDQSLFRLWLAEKE O08614_MOUSE O08614_MOUSE NSGESATALLEDQLQKLGERWTAVCRWTEERWNRLQEISILWQELLEEQCLLEAWLTEKE O55147_RAT O55147_RAT NSGESATAVLEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLEAWLTEKE Q5JCF5_CANFA Q5JCF5_CANFA NSGESATAVLEDQLQKLGERWTAVCRWTEERWSRLQEINILWQELLEEQCLLKAWLTEKE UTRO_HUMAN UTRO_HUMAN NSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKE MATCH .**: *** **:**: :*.**: :*****:** **:: **.: .:*.*: **:*** CONSENSUS ?SG??ATA?LE?QL??LG?RW???CRWTE?RW??LQ?I???WQ???EEQCL???WL?EKE

DMD_CHICK DMD_CHICK GSLSKIQTSDFKDENEMLTSLRKLAILKGDIEMKKQMMSKLKSLSRDLLVAVKNKAVAQK A2A9Z0_MOUSE A2A9Z0_MOUSE DAMKNIQTSGFKDQNEMMSSLHKISTLKIDLEKKKPTMEKLSSLNQDLLSALKNKSVTQK DMD_MOUSE DMD_MOUSE DAMKNIQTSGFKDQNEMMSSLHKISTLKIDLEKKKPTMEKLSSLNQDLLSALKNKSVTQK DMD_PIG DMD_PIG DALNKIHTTGFKDQGEMLSSLQKLAVLKTDLEKKKQTMDKLSSLNQDLLSTLKNTLVAQK DMD_HUMAN DMD_HUMAN DAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQK DMD_CANFA DMD_CANFA DAVNKIHTTGFKDQSEVLSNLQKLAVLKTDLEKKKQTMDKLCSLNQDLLSALKNTVVAHK Q4S6Z2_TETNG Q4S6Z2_TETNG EALNEVQSSNFRDPNKMNTNVRHLAILKEDMEKKKRTLDQLSDAGQDVMALLRSPEAGGK O08614_MOUSE O08614_MOUSE EALDKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLSNPKASKK O55147_RAT O55147_RAT EALNKVQTGNFKDQKELGVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLSNPKASEK Q5JCF5_CANFA Q5JCF5_CANFA EALNKVQTSNFKDQKELSVSIRRLAILKEDMEMKRQALDQLSEIGQDVGQLVDNPKASKK UTRO_HUMAN UTRO_HUMAN EALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKK MATCH ::.:::: .*:* :: .::::: ** *:* *: : :* . :*: : . . * CONSENSUS ?A?????T??FKDQ?E???S???LA?LK?D?E?K??????L????QD????L?N?????K

DMD_CHICK DMD_CHICK LESRLENFAQRWDSLVQKLESDSKQVSQAVTTTQTSLTQTTVMETVTMVTTREQILVKHA A2A9Z0_MOUSE A2A9Z0_MOUSE MEIWMENFAQRWDNLTQKLEKSSAQISQAVTTTQPSLTQTTVMETVTMVTTREQIMVKHA DMD_MOUSE DMD_MOUSE MEIWMENFAQRWDNLTQKLEKSSAQISQAVTTTQPSLTQTTVMETVTMVTTREQIMVKHA DMD_PIG DMD_PIG MEAWLDNFAQRWDNLVQKLEKSSTQISQAVTTTQPSLTQTTVMETVTMVTTREQILVKHA DMD_HUMAN DMD_HUMAN TEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHA DMD_CANFA DMD_CANFA MEAWLDNFAQRWDNLVQKLEKSSAQISQAVTTTQPSLTQTTVMETVTMVTTREHILVKHA Q4S6Z2_TETNG Q4S6Z2_TETNG IEADTEELAQRWDNLVQKLEDCSFQVCTIV--TDAGVTQEEEQVIVDTVTV--GAAASRT O08614_MOUSE O08614_MOUSE MNSDSEELTQRWDSLVQRLEDSSNQVTQAV--AKLGMSQIPQKDLLETVHVREQGMVKKP O55147_RAT O55147_RAT MNSDSEELTQRWDSLVQRLEDSSNQVTQAV--AKLGMSQIPQKDLLETVHVREQGMIKKP Q5JCF5_CANFA Q5JCF5_CANFA INSDSEELTQRWDSLVQRLEDSSNQVTQAV--AKLGMSQIPQKDLLETVRIREQVTTKRS UTRO_HUMAN UTRO_HUMAN INSDSEELTQRWDSLVQRLEDSSNQVTQAV--AKLGMSQIPQKDLLETVRVREQAITKKS MATCH : ::::: **.*.*:**. : *: * :. .::* : * .:. CONSENSUS ?????????QRWD?LVQ?LE?SS?Q??QAV????????Q?????????V??REQ???K??

DMD_CHICK DMD_CHICK KEELPPPPPHKKRQLLVDSEIRKRFDSDTTELHSWMTRSEAVLQSPEFAIYRKEGNLSDL A2A9Z0_MOUSE A2A9Z0_MOUSE QEELPPPPPQKKRQITVDSELRKRLDVDITELHSWITRSEAVLQSSEFAVYRKEGNISDL DMD_MOUSE DMD_MOUSE QEELPPPPPQKKRQITVDSELRKRLDVDITELHSWITRSEAVLQSSEFAVYRKEGNISDL DMD_PIG DMD_PIG QEELPPPPPQKKRQIIVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIYRKEGNFSDL DMD_HUMAN DMD_HUMAN QEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDL DMD_CANFA DMD_CANFA QEELPPPPPQKKRQIIVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIYRKEGNFSDL Q4S6Z2_TETNG Q4S6Z2_TETNG DVHLTPLASSKNWLAGKDPEVTRMFESKCSQLLSWIKTWKTSVQAVASADPETTPDSSDL O08614_MOUSE O08614_MOUSE KQELPPPPPPKKRQIHVDVEAKKKFDAISTELLNWILKSKTAIQNTEMKEYKKSQETSGM O55147_RAT O55147_RAT KQELPPPPPPKKRQIHVDVEAKKKFDATSAELQSWILRSKAALQNTEMNEYKKSQETSGV Q5JCF5_CANFA Q5JCF5_CANFA KQELPPPPPPKKRQIPVDIEAKKKFDAASAELLNCILKSKTAIQAAEIKGYKKMQETSEM UTRO_HUMAN UTRO_HUMAN KQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTSEM MATCH . .*.* .. *: * * : :: ::* . : :: :* . : * : CONSENSUS ??ELPPPPP?KKRQI?VD?E??K??D????EL??WI??S????Q??E???Y?K????S??

DMD_CHICK DMD_CHICK RERVNAIQREKPEKYRKLQDASRSAEALVEQMVNEGLNADNIRQASEQLKSRWIEFCQLL A2A9Z0_MOUSE A2A9Z0_MOUSE QEKVNAIAREKAEKFRKLQDASRSAQALVEQMANEGVNAESIRQASEQLNSRWTEFCQLL DMD_MOUSE DMD_MOUSE QEKVNAIAREKAEKFRKLQDASRSAQALVEQMANEGVNAESIRQASEQLNSRWTEFCQLL DMD_PIG DMD_PIG KEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAAEQLNSRWIEFCQLL DMD_HUMAN DMD_HUMAN KEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLL DMD_CANFA DMD_CANFA KEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLL Q4S6Z2_TETNG Q4S6Z2_TETNG PADLKALDLDFMTKGATVIQVIQEGRDLVDQMDRVGWCSRELQAASERVCT--------- O08614_MOUSE O08614_MOUSE KKKLKGLEKEQKENLPRLDELNQTGQTLREQMGKEGLPLKEVNDVLERVSLEWKMISQQL O55147_RAT O55147_RAT RKKWKGLEKEQKEKIPQLDELNQTGQILQEQMGKEGLLAEEINDVLERVLLEWKMISQQL Q5JCF5_CANFA Q5JCF5_CANFA KKKLKGLQKEQTERSPRLDELNQTGQVLLEQMGKEGIPTEEIKNVLEKVFSEWKDISQHL UTRO_HUMAN UTRO_HUMAN KKKLKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHL MATCH :.: : . : : .. * :** . * .:. . *:: CONSENSUS ??K??????E??E????L???????Q?L?EQM??EG?????I????E?????W????Q?L

DMD_CHICK DMD_CHICK SERLVWLEYQNSIIDFYSQLQRLEQTAITAENWLKAQPTPA--TDPATVKIQLEKCKDEI A2A9Z0_MOUSE A2A9Z0_MOUSE SERVNWLEYQTNIITFYNQLQQLEQMTTTAENLLKTQSTTL--SEPTAIKSQLKICKDEV DMD_MOUSE DMD_MOUSE SERVNWLEYQTNIITFYNQLQQLEQMTTTAENLLKTQSTTL--SEPTAIKSQLKICKDEV DMD_PIG DMD_PIG SERLNWLEYQNRIITFYNQLQQLEQITTAAENWLKTQPITT--SEPTAVKSQLKICKDEV DMD_HUMAN DMD_HUMAN SERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTP--SEPTAIKSQLKICKDEV DMD_CANFA DMD_CANFA SERLNWLEYQNNIITFYNQLQQLEQMTTTAENWLKTQPTTT--SEPTAIKSQLKICKDEI Q4S6Z2_TETNG Q4S6Z2_TETNG ---------QSRVNTLSTELADVDRSLGEQDQWIESDLAMPKCNDESELRRQIRDCEDRI O08614_MOUSE O08614_MOUSE EDLGRKIQLQEDINAYFKQLDAIEETIKEKEEWLRGTPISE--SPRQPLPGLKDSCQREL O55147_RAT O55147_RAT EDLGRKIQLQEDINAYFRQLDALEKTIRAKEEWLRDASFSE--SPQRSLPSLKDSCQREL Q5JCF5_CANFA Q5JCF5_CANFA EDLARKIQLQEDINAYFKQLDDLEKIVKTKEEWVKHTPFLE--APQRPSPSLKDSCQREL UTRO_HUMAN UTRO_HUMAN EDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISE--SSRQSLPSLKDSCQREL MATCH * : :* ::. :: :. *: .: CONSENSUS ?????????Q??I?????QL??LE??????E?W??????????????????????C??E?

DMD_CHICK DMD_CHICK IRMSTLQPQIERLKAQSQALKEKEQCPVFLDADLAAFTSHFKQILADMHTREKQLQTIFD A2A9Z0_MOUSE A2A9Z0_MOUSE NRLSALQPQIEQLKIQSLQLKEKGQGPMFLDADFVAFTNHFNHIFDGVRAKEKELQTIFD DMD_MOUSE DMD_MOUSE NRLSALQPQIEQLKIQSLQLKEKGQGPMFLDADFVAFTNHFNHIFDGVRAKEKELQTIFD DMD_PIG DMD_PIG NRLSALQPQIERLKIESIALKEKGQGPMFLDADSVAFTNHFNQVFADMQAKEKELQIIFD DMD_HUMAN DMD_HUMAN NRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFD DMD_CANFA DMD_CANFA NRLSALQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFNQVFADVQAREKELQTIFD Q4S6Z2_TETNG Q4S6Z2_TETNG VLVTALGPQLEQLSADTRSLGAVPSLKD----NIVVVSAHHAS----------------- O08614_MOUSE O08614_MOUSE TDLLGLHPRIETLCASCSALKSQPCVPGFVQQGFDDLRHHYQAVAKALEEYQQQLENELK O55147_RAT O55147_RAT TDLLGLHPRIEILCASCSALRSQPSVPGFVQQGFDDLRRHYQAVQKALEEYQQQLENELK Q5JCF5_CANFA Q5JCF5_CANFA TDLLGLHPKIEMARAYCLALKSRPLAPDFVQQGFESLLGRYQAVRQELEHRQQQLENELK UTRO_HUMAN UTRO_HUMAN TNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELK MATCH : * *::* * . . :. CONSENSUS ??L??L?P?IE?L??????L??????P?F??????????H??????????????L?????

DMD_CHICK DMD_CHICK SLPPARYKDTVTTILSWIQQSETKVSIPPVAVAEYEIMEQRLGELKALQSSLQEQQKGLK A2A9Z0_MOUSE A2A9Z0_MOUSE TLPPMRYQETMSSIRTWIQQSESKLSVPYLSVTEYEIMEERLGKLQALQSSLKEQQNGFN DMD_MOUSE DMD_MOUSE TLPPMRYQETMSSIRTWIQQSESKLSVPYLSVTEYEIMEERLGKLQALQSSLKEQQNGFN DMD_PIG DMD_PIG TLPPMRYQETMSTILTWIQHSEAKLSIPQATVTEYEIMEQRLGELQALQSSLQEQQNGLN DMD_HUMAN DMD_HUMAN TLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLY DMD_CANFA DMD_CANFA SLPPMRYQETMSTILTWIQQSETKLSIPQVTVTEYDIMEQRLGELQALQSSLQEQQNGLN Q4S6Z2_TETNG Q4S6Z2_TETNG ------TLQRLEDTKDALSKAEG-----------------AVGRAQSLCLEIEQTQQA-- O08614_MOUSE O08614_MOUSE SQPGPEYLDTLNTLKKMLSESEKAAQASLNALNDPIAVEQALQEKKALDETLENQKHTLH O55147_RAT O55147_RAT SQPEPAYLDTLNTLKKMLSESEKAAQASLSALNDPSAVEQALQEKKALDETLENQKPTLH Q5JCF5_CANFA Q5JCF5_CANFA SQPGRAYLETLKTLKNTLNDSESKAQTSLNVLNDLTKLEKALQEKKALDEILENQRPTLY UTRO_HUMAN UTRO_HUMAN GQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEILENQKPALH MATCH : : :..:* : . ::* ::: : CONSENSUS ??P???Y??T??????????SE????????????????E??L????AL???L??Q?????

DMD_CHICK DMD_CHICK YLNTTVEDLSRKAP-AEVSQKYRSEVELIVGRWKKLSSQLVEHCQKLEDLMTKLQRFQND A2A9Z0_MOUSE A2A9Z0_MOUSE YLSDTVKEMAKKAP-SEICQKYLSEFEEIEGHWKKLSSQLVESCQKLEEHMNKLRKFQNH DMD_MOUSE DMD_MOUSE YLSDTVKEMAKKAP-SEICQKYLSEFEEIEGHWKKLSSQLVESCQKLEEHMNKLRKFQNH DMD_PIG DMD_PIG YLSTTVKEMSKKAP-SNISRKYQSEFEEIEGRWKKLSAQLMEHCQKLEEQIAKLRKLQNH DMD_HUMAN DMD_HUMAN YLSTTVKEMSKKAP-SEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNH DMD_CANFA DMD_CANFA YLSTTVKEMSKKAPLSDISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMAKLRKIQNH Q4S6Z2_TETNG Q4S6Z2_TETNG ---------------SDVA-----EFE----RWSQLSTKAREGLATLQCTLGSMREYQVS O08614_MOUSE O08614_MOUSE KLSEETKTLEKNML-PDVGKMYKQEFDDVQGRWNKVKTKVSRDLHLLEEITPRLRDFEAD O55147_RAT O55147_RAT KLSEETKALEKNML-PDVGKTYRQEFDDAQGKWNKVKTKVSRDLRSLEEIIPRLRDFKAD Q5JCF5_CANFA Q5JCF5_CANFA TLAEETKALEKTVS-PDVEKMYKQEFDDVQGKWNKLKVKVSKDLHLLEEITSKLRAFEAD UTRO_HUMAN UTRO_HUMAN KLAEETKALEKNVH-PDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLRAFEAD MATCH .:: *.: :*.::. . *: :: : CONSENSUS ?L????K???K??????????Y??EF????G?W?KL??????????LEE????LR?????

DMD_CHICK DMD_CHICK TKTLKKWMAEVDVFLKEEWPALGDSEALEKQLEQCTALVNDIQTIQPSLNSVNEIGKKMK A2A9Z0_MOUSE A2A9Z0_MOUSE IKTLQKWMAEVDVFLKEEWPALGDAEILKKQLKQCRLLVGDIQTIQPSLNSVNEGGQKIK DMD_MOUSE DMD_MOUSE IKTLQKWMAEVDVFLKEEWPALGDAEILKKQLKQCRLLVGDIQTIQPSLNSVNEGGQKIK DMD_PIG DMD_PIG IKTLKNWMAEVDIFLKEEWPALGDSEILRKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIK DMD_HUMAN DMD_HUMAN IQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIK DMD_CANFA DMD_CANFA IKTLKKWITEVDVFLKEEWPALGDSEILKRQLKQCRLLVNDIQTIQPSLNSVNEGAQKMK Q4S6Z2_TETNG Q4S6Z2_TETNG LVEVERWLDAVQEMLSNDATGLSKRENLQEELNNCKEYMNEMESVDCALKQMGENVSTLQ O08614_MOUSE O08614_MOUSE SEVIEKWVSGIKDFLMKEQAAQGDAAA-QSQLDQCATFANEIETIESSLKNMREVETSLQ O55147_RAT O55147_RAT SEVIEKWTNGVKDFLMKEQAAQGDTTALQRQLDQCTTFANEIETIESSLKNLRDIETSLQ Q5JCF5_CANFA Q5JCF5_CANFA SKVIEKWMDGVKDF-MKEQAVQRDAEGLQSQLDQCCGFVNEIETVESSLKDMKEIETNLR UTRO_HUMAN UTRO_HUMAN STVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLR MATCH ::.* :. : :: . . . :*.:* .:::::: :*:.: : .:: CONSENSUS ?????KW???V??FL??E??A?GD???L??QL?QC??????I?TI??SL????E??????

DMD_CHICK DMD_CHICK REAEPEFASRIATELKDLNAQWEHICQQAHAKKAALKGGLDKTVSLRKDLSEMHEWITQA A2A9Z0_MOUSE A2A9Z0_MOUSE SEAELEFASRLETELRELNTQWDHICRQVYTRKEALKAGLDKTVSLQKDLSEMHEWMTQA DMD_MOUSE DMD_MOUSE SEAELEFASRLETELRELNTQWDHICRQVYTRKEALKAGLDKTVSLQKDLSEMHEWMTQA DMD_PIG DMD_PIG KEAEPEFASRLETELRELNTQWDYICRQVYARKEALKGGLDKTISLQKDLSEMHEWMTQA DMD_HUMAN DMD_HUMAN NEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQA DMD_CANFA DMD_CANFA NEAEPEFAGRLETELRELNTQWDYMCRQVYARKEALKGGLDKTVSLQKDLSEMHEWMTQA Q4S6Z2_TETNG Q4S6Z2_TETNG TAQVPALANWGQDKLSECQSRWDSLSKQLLVHQEQVAESREKQVNLRKDLLEMQEWMAQV O08614_MOUSE O08614_MOUSE RCPVTGVKTWVQARLVDYQSQLEKFSKEIAIQKSRLLDSQEKALNLKKDLAEMQEWMAQA O55147_RAT O55147_RAT RCPVTGVKTWVQTRLADYQSQLEKFSQEIDIQKSRLSDSQEKAMNLKKDLAEMQEWMAQA Q5JCF5_CANFA Q5JCF5_CANFA SYPVAGIKTWMQTKLVDYQTQLEKFSKEIAIQKNRLSESQEKAVNLKKDLAEMQEWMTQA UTRO_HUMAN UTRO_HUMAN SGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQA MATCH . .* : ::: : :.:: :: : . :* .*:*** **:**::*. CONSENSUS ????????????T?L?????Q???????????K??L?????K???L?KDL?EM?EWM?QA

DMD_CHICK DMD_CHICK EEEYLERDFEYKTPEELQKAVEELKRAKEDAMQKEVKVKLITDSVNNFIAKAPP----AA A2A9Z0_MOUSE A2A9Z0_MOUSE EEEYLERDFEYKTPDELQTAVEEMKRAKEEALQKETKVKLLTETVNSVIAHAPP----SA DMD_MOUSE DMD_MOUSE EEEYLERDFEYKTPDELQTAVEEMKRAKEEALQKETKVKLLTETVNSVIAHAPP----SA DMD_PIG DMD_PIG EEEYLERDFEYKTPDELQTAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPP----AA DMD_HUMAN DMD_HUMAN EEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPP----VA DMD_CANFA DMD_CANFA EEEYLERDFEYKTPDELQTAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPP----AA Q4S6Z2_TETNG Q4S6Z2_TETNG DEEFLMRDFEYKSPEELEASLEEMKRAKEDVLQKEVKVKILKDSIHLLVSRTSPSAGHSG O08614_MOUSE O08614_MOUSE EEDYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDSIKLVAAKVPS----GG O55147_RAT O55147_RAT EEDYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDSIKLVAARVPS----GG Q5JCF5_CANFA Q5JCF5_CANFA EEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDNIMLLAAKAPS----GG UTRO_HUMAN UTRO_HUMAN EEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPS----GG MATCH :*::* ******:*:**: ::**:*****:. ***.:**::.:.: . ::... . CONSENSUS EEEYLERDFEYK?P?EL??AVEEMKRAKE???QKE??VK?L????????A??P???????

DMD_CHICK DMD_CHICK NEALKKELDVLITSYQRLCSRLNGKCKTLEEVWACWHELLSYLDAENKWLNEVELKLKAT A2A9Z0_MOUSE A2A9Z0_MOUSE QEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVELKLKTM DMD_MOUSE DMD_MOUSE QEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVELKLKTM DMD_PIG DMD_PIG QEALKKELDTLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLSEVEFKLKTT DMD_HUMAN DMD_HUMAN QEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTT DMD_CANFA DMD_CANFA QEALKKELDTLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLSEVEVKLKTT Q4S6Z2_TETNG Q4S6Z2_TETNG QE-LTVELERVLANYHKLCDRFKSKCHTLEEVWSCWIELLQYLDMEHSWVNTLEEKVKAT O08614_MOUSE O08614_MOUSE QE-LTSEFNEVLESYQLLCNRIRGKCHTLEEVWSCWVELLHYLDLETTWLNTLEERVRST O55147_RAT O55147_RAT QE-LTSEFNEVLESYQLLCNRIRGKCHTLEEVWSCWVELLHYLDLETAWLNTLEERMQST Q5JCF5_CANFA Q5JCF5_CANFA QE-LTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKST UTRO_HUMAN UTRO_HUMAN QE-LTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKST MATCH :* *. *:: : .*: ** *:..**:******:** *** **: *:. :* :::: CONSENSUS QE?L??EL??????YQ?LC?R??GKC?TLEEVW?CW?ELL?YL?????WLN??E???K?T

DMD_CHICK DMD_CHICK ENIQGGAEEISESLDSLERLMRHPEDNRNQIRELAQTLTDGGILDELINEKLEKFNTRWE A2A9Z0_MOUSE A2A9Z0_MOUSE ENVPAGPEEITEVLESLENLMHHSEENPNQIRLLAQTLTDGGVMDELINEELETFNSRWR DMD_MOUSE DMD_MOUSE ENVPAGPEEITEVLESLENLMHHSEENPNQIRLLAQTLTDGGVMDELINEELETFNSRWR DMD_PIG DMD_PIG ENIPGGAEEISEVLESLENLMQHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWR DMD_HUMAN DMD_HUMAN ENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWR DMD_CANFA DMD_CANFA ENISGGAEEIAEVLDSLENLMQHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWR Q4S6Z2_TETNG Q4S6Z2_TETNG DNLPESTEAVSEALESLESALRHPGDNRTQIRELGQTLVDGGILDELISEKLEAFNSQYE O08614_MOUSE O08614_MOUSE EALPERAEAVHEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYE O55147_RAT O55147_RAT EALPERAEAVHDALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYE Q5JCF5_CANFA Q5JCF5_CANFA EALPEKADAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNNRYE UTRO_HUMAN UTRO_HUMAN EVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYE MATCH : : .: : : *:*** ::*. :* .*** *.*** ***::*::*.*:** **.::. CONSENSUS E??P???E???E?L?SLE????H??DN??QIR?L?QTL?DGG??D??I?E?LE?FNSR??

DMD_CHICK DMD_CHICK ELQQEAVRRQKSLEQSIQSAQETDKTLRLIQESLAAIDKQLTAYTADRVDAAQVPQEAQK A2A9Z0_MOUSE A2A9Z0_MOUSE ELHEEAVRKQKLLEQSIQSAQEIEKSLHLIQESLEFIDKQLAAYITDKVDAAQMPQEAQK DMD_MOUSE DMD_MOUSE ELHEEAVRKQKLLEQSIQSAQEIEKSLHLIQESLEFIDKQLAAYITDKVDAAQMPQEAQK DMD_PIG DMD_PIG ELHEEAVRRQKLLEQSIQSAQEIEKSLHLIQDSLSSIDHQLAVYIADKVDAAQMPQEAQK DMD_HUMAN DMD_HUMAN ELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK DMD_CANFA DMD_CANFA ELHEEAVRRQKLLEQSIQSAQEIEKSLHLIQESLSSIDKQLAAYIADKVDAAQMPQEAQK Q4S6Z2_TETNG Q4S6Z2_TETNG QLNHQVVNRQISLEQQLQTLKENEQALQTLQESLSQLDHTLTSYLTDRIDAFRLPQEAQT O08614_MOUSE O08614_MOUSE ELSHLAESKQISLEKQLQVLRETDHMLQVLKESLGELDKQLTTYLTDRIDAFQLPQEAQK O55147_RAT O55147_RAT ELSHLAESKQISLEKQLQVLRETDHMLQVLKESLGELDKQLTTYLTDRIDAFQLPQEAQK Q5JCF5_CANFA Q5JCF5_CANFA ELSHLAESKQISLEKQLQVLRETDHMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQK UTRO_HUMAN UTRO_HUMAN DLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQK MATCH :* . . :* **:.:* :* :: *: :::** :*: *: * :*::** ::*****. CONSENSUS EL???A???Q??LE???Q???E????L???QESL???DKQL??Y??D??DA?Q?PQEAQK

DMD_CHICK DMD_CHICK IQSELTSHEISLEEMKK-------RNRGKESAKRVLSQIDVAQKKLQDVSMKFRLFQKPA A2A9Z0_MOUSE A2A9Z0_MOUSE IQSDLTSHEISLEEMKK-------HNQGKDANQRVLSQIDVAQKKLQDVSMKFRLFQKPA DMD_MOUSE DMD_MOUSE IQSDLTSHEISLEEMKK-------HNQGKDANQRVLSQIDVAQKKLQDVSMKFRLFQKPA DMD_PIG DMD_PIG IQSDLTSHEISLEEMKK-------HYQGKEAAPRVLSQIELAQKKLQDVSMKFRLFQKPA DMD_HUMAN DMD_HUMAN IQSDLTSHEISLEEMKK-------HNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPA DMD_CANFA DMD_CANFA IQSDLTSHEISLEEMKK-------HNQGKETAQRVLSQIDVAQKKLQDVSMKFRLFQKPA Q4S6Z2_TETNG Q4S6Z2_TETNG IGAEIAAHELTVEDMRRRNVANLPPSTSDGKASRGGTMLDHLQRKLREISTKYQLFQKPA O08614_MOUSE O08614_MOUSE IQAEISAHELTLEELRK-NVRSQPPTSPEGRATRGGSQMDMLQRKLREVSTKFQLFQKPA O55147_RAT O55147_RAT IQAEISAHELTLEELKK-NVRPQPPTSPEGRTTRGGSQMDLLQRKLREVSTKFQLFQKPA Q5JCF5_CANFA Q5JCF5_CANFA IQAEISAHELTLEELRR-NIRSQPPTSPESRNARGGSQMDVLQRKLREVSTKFQLFQKPA UTRO_HUMAN UTRO_HUMAN IQAEISAHELTLEELRR-NMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPA MATCH * :::::**:::*:::: . * : :: *:**:::* *::****** CONSENSUS IQ?????HE??LEE???????????????????R??SQ?D??Q?KL??VS?KF?LFQKPA

DMD_CHICK DMD_CHICK NFEQRLQECKRILDEVKLQVPKLETKSVEQEVVQSHLDHCMKLYKSLSEVKSEVETVIKT A2A9Z0_MOUSE A2A9Z0_MOUSE NFEQRLEESKMILDEVKMHLPALETKSVEQEVIQSQLSHCVNLYKSLSEVKSEVEMVIKT DMD_MOUSE DMD_MOUSE NFEQRLEESKMILDEVKMHLPALETKSVEQEVIQSQLSHCVNLYKSLSEVKSEVEMVIKT DMD_PIG DMD_PIG NFEQRLQESKMILDEVKMHLPALEIKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKT DMD_HUMAN DMD_HUMAN NFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKT DMD_CANFA DMD_CANFA NFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKT Q4S6Z2_TETNG Q4S6Z2_TETNG NFEQRMLDCKRVLDGAKTELHILDVKDVEPEKIQSHLAGCM------------------- O08614_MOUSE O08614_MOUSE NFEQRMLDCKRVLEGVKAELHVLDVRDVDPDVIQAHLDKCMKLYKTLSEVKLEVETVIKT O55147_RAT O55147_RAT NFEQRMLDCKRVLDGVKAELHVLSVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKT Q5JCF5_CANFA Q5JCF5_CANFA NFEQRMLDCKRVLDCVKAELHVLDVKDVDPDIIQNHLDKCMKLYKTLSEVKLEVETVIKT UTRO_HUMAN UTRO_HUMAN NFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKT MATCH *****: :.* :*: .* .: *. :.*: : :* :* *: CONSENSUS NFEQR????K??LD?VK??L??L??K?V???V?Q??L??C??LYK?LSEVK?EVE?VIKT

DMD_CHICK DMD_CHICK GRQIVQKQQTENPKELDERLTALKLQYNELGAKVTEKKQELEKCLKLSRKLRKEINSLTE A2A9Z0_MOUSE A2A9Z0_MOUSE GRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTE DMD_MOUSE DMD_MOUSE GRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTE DMD_PIG DMD_PIG GRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTE DMD_HUMAN DMD_HUMAN GRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTE DMD_CANFA DMD_CANFA GRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNALTE Q4S6Z2_TETNG Q4S6Z2_TETNG ---------------------------------VTERKQHLEKALSLSQKFQKESTIFHH O08614_MOUSE O08614_MOUSE GRHIVQKQQTDNPKSMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLSRKMKKEAAVLSE O55147_RAT O55147_RAT GRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLSRKLKKEAAILSE Q5JCF5_CANFA Q5JCF5_CANFA GRHIVQKQQTDNPKGMDEQLTSLKILYNDLGAQVTEGKQDLERASQLARKMKKDTASLSE UTRO_HUMAN UTRO_HUMAN GRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSE MATCH *** **.**:. .*::*::*: : . CONSENSUS GR?IVQK?QT?NPK??DE??T?LK??YN?LGA?VTE?KQ?LE????LSRK??KE???L?E

DMD_CHICK DMD_CHICK WLAATDVELTKRSAVQGMPSNLDAEIAWGKATRKEIEKRQVQLKNICDLGENLKTVLKGK A2A9Z0_MOUSE A2A9Z0_MOUSE WLAATDTELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKAHLKSVTELGESLKMVLGKK DMD_MOUSE DMD_MOUSE WLAATDTELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKAHLKSVTELGESLKMVLGKK DMD_PIG DMD_PIG WLAATDTELTKRSAVEGMPSNLDSEVVWGKATQKEIEKQKFHLKSISEIGEALKMVLGKK DMD_HUMAN DMD_HUMAN WLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKK DMD_CANFA DMD_CANFA WLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSVTEVGEALKTVLGKK Q4S6Z2_TETNG Q4S6Z2_TETNG SLITSEAQLHQNNSSPDIPADIDAEIAWANGLLKETERRKVDLSNLTENSAGLQTLVEGS O08614_MOUSE O08614_MOUSE WLSATEAELVQKSTSEGVIGDLDTEISWAKSILKDLEKRKVDLNGITESSAALQHLVLGS O55147_RAT O55147_RAT WLSTTEAELVQKSASEGVIGDLDTEISWAKNILKDLEKRKVDLNTITESSAALQHLVVGS Q5JCF5_CANFA Q5JCF5_CANFA WLSVTETELVQKSTSEGLLGDLDVEISWAKNVLKDLEKRKADLNTITESSAALQNLIEGS UTRO_HUMAN UTRO_HUMAN WLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLIEGS MATCH * .:: :* :..: .: .::* *: *.: *: *::: .*. : : . *: :: . CONSENSUS WL??T??EL???S??EG????LD?E??W?K???K??EK?K??L???TE????L???????

DMD_CHICK DMD_CHICK ESLVEDKLSLLNSNWIAVTSRAEEWLNLLMEYQKHMEAFDQKVANVTTWIYRAEILLDES A2A9Z0_MOUSE A2A9Z0_MOUSE ETLVEDKLSLLNSNWIAVTSRVEEWLNLLLEYQKHMETFDQNIEQITKWIIHADELLDES DMD_MOUSE DMD_MOUSE ETLVEDKLSLLNSNWIAVTSRVEEWLNLLLEYQKHMETFDQNIEQITKWIIHADELLDES DMD_PIG DMD_PIG ETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMENFDQNVDHITKWIIQADTLLDES DMD_HUMAN DMD_HUMAN ETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDES DMD_CANFA DMD_CANFA EMLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDYITNWIIQADALLDES Q4S6Z2_TETNG Q4S6Z2_TETNG GAQLEDKLCVLNEAWDHVRTLTEDWLSAVLSHQNEVEIFDENLAHISTWLYQTQIHLDEA O08614_MOUSE O08614_MOUSE ESVLEENLCVLNAGWSRVRTWTEDWCNTLLNHQNQLELFDGHVAHISTWLYQAEALLDEI O55147_RAT O55147_RAT ESVLEDTLCVLNAGWSRVRTWTEDWRNTLLNHQNQLEVFDGHVAHISTCLYQAEALLDEI Q5JCF5_CANFA Q5JCF5_CANFA EPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEVFDGNVAHISTWLYQAEALLDEI UTRO_HUMAN UTRO_HUMAN EPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEI MATCH :*: *.:** * * : .*:* . ::.:*:.:* ** :: ::. : ::: *** CONSENSUS E???E??L??LN??W??V????E?W?N?L???Q???E?FD?????I??W???A??LLDE?

DMD_CHICK DMD_CHICK DKQKPQQKEETLKRLKAELNDMHPKVDSVRDQAVDLMTNRGDHCRKVIEPKLSELNHRFA A2A9Z0_MOUSE A2A9Z0_MOUSE EKKKPQQKEDILKRLKAEMNDMRPKVDSTRDQAAKLMANRGDHCRKVVEPQISELNRRFA DMD_MOUSE DMD_MOUSE EKKKPQQKEDILKRLKAEMNDMRPKVDSTRDQAAKLMANRGDHCRKVVEPQISELNRRFA DMD_PIG DMD_PIG EKKKPQQKEDVLKRLKAEMNDMRPKVDSTRDQAANLMANRGDHCRKVIEPKISELNHRFA DMD_HUMAN DMD_HUMAN EKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFA DMD_CANFA DMD_CANFA EKKKPQQKEDILKRLKAEMNDIRPKVDSTRDQAANLMANRGDHCRKVVEPKISELNHRFA Q4S6Z2_TETNG Q4S6Z2_TETNG ERLPPAEREKVVKRVLEELRDISLRVDNVKDQAIILMTSRGPACRDVVEPKLSELNFNFD O08614_MOUSE O08614_MOUSE EKKPASKQEEIVKRLLSELDDASLQVENVREQAIILVNARGSASRELVEPKLAELSRNFE O55147_RAT O55147_RAT EKKPASKQEEIVKRLLSELSDASIQVENVREQAIVLVNARGSSSRELVEPKLAELGKNFE Q5JCF5_CANFA Q5JCF5_CANFA EKKPASKREKIVKRLISELDDANLQVENVRDQAVVLMNARGGSSWELVEPKLAELNRNFE UTRO_HUMAN UTRO_HUMAN EKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFE MATCH :: . ::*. :**: *: * :*:..::** *: ** . .::**:::**. .* CONSENSUS EKK?????E???KRL??E??D????V???RDQA??LM??RG???R??VEP???ELN??F?

DMD_CHICK DMD_CHICK AISQRIKSGK--------------------PFIPLKELEQFDFDIQKLLEPLEVEIQQGV A2A9Z0_MOUSE A2A9Z0_MOUSE AISHRIKTGK--------------------ASIPLKELEQFNSDIQKLLEPLEAEIQQGV DMD_MOUSE DMD_MOUSE AISHRIKTGK--------------------ASIPLKELEQFNSDIQKLLEPLEAEIQQGV DMD_PIG DMD_PIG AISHRIKTGK--------------------ASIPLKELEQFNSDIQKLLEPLEAEIQQGV DMD_HUMAN DMD_HUMAN AISHRIKTGK--------------------ASIPLKELEQFNSDIQKLLEPLEAEIQQGV DMD_CANFA DMD_CANFA AISHRIKTGK--------------------ASIPLKELEQFNSDIQKLLEPLEAEIQQGV Q4S6Z2_TETNG Q4S6Z2_TETNG KVSQHIRTAQLIQNQE--------IQAESHPDSHLTEVKDLHAELQNTLTTLQQQ-DPSE O08614_MOUSE O08614_MOUSE KVSQHIKSARMLIGQDPSSYQGLDPAGTVQAAESFSDLENLEQDIENMLKVVEKHLDPN- O55147_RAT O55147_RAT KVSQHINSAQMLIGQD--------PAGTVEAVGPFSDLESLESDIENMLKVVEKHLDPS- Q5JCF5_CANFA Q5JCF5_CANFA KVSQHIRSANLLIGQEPLSYQRLVTTEAFEADVLFSDLEKLESDIENMLKVVEKHLEFSG UTRO_HUMAN UTRO_HUMAN KVSQHIKSAKLLIAQEPL-YQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSD MATCH :*::*.:.. . :.:::.:. :::: * :: . : . CONSENSUS ??S??I???????????????????????????????LE????DI???L???E???????

DMD_CHICK DMD_CHICK NLKEEDFNKDMSEDDESTVKELLQRGDTLQKRITDERKREEIKIKQQLLQTKHNALKDLR A2A9Z0_MOUSE A2A9Z0_MOUSE NLKEEDFNKDMSEDNEGTVNELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLR DMD_MOUSE DMD_MOUSE NLKEEDFNKDMSEDNEGTVNELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLR DMD_PIG DMD_PIG NLKEEDFNKDMSEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLR DMD_HUMAN DMD_HUMAN NLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLR DMD_CANFA DMD_CANFA NLKEEDFNKDMSEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLR Q4S6Z2_TETNG Q4S6Z2_TETNG LLDDEKM-----DEEKAGVEDLLRRGEELLQQTTDESQKEEFRLLLLRLQSQYSAHREK- O08614_MOUSE O08614_MOUSE --NDEKM-----DEEQAQIEEVLQRGEHLLHEPMEDSKKEKIRLQLLLLHTRYNKIKTI- O55147_RAT O55147_RAT --NDEKM-----DEERAQIEEVLQRGEHLLHEPMEDSKKEKIRLQLLLLHTRYNKIKAI- Q5JCF5_CANFA Q5JCF5_CANFA --EDEKV-----DEERAQIEEVLQRGEQMLHQPMEDNKKEKIRLQLLLLRTRYNKTKTV- UTRO_HUMAN UTRO_HUMAN --EDEKM-----DEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAI- MATCH .:*.. ::: . ::::*:**: : :. :: ::*:::: *::::. : CONSENSUS ????E???????????????E?LQRG??L????????K?E?I?????LL?T??N??K???

DMD_CHICK DMD_CHICK SQRRKKALEISHQWYQYKRQADDLMTWLDDIEKKLASLPDHKDEQKLKEIGGELEKKKED A2A9Z0_MOUSE A2A9Z0_MOUSE SQRRKKALEISHQWYQYKRQADDLLKCLDEIEKKLASLPEPRDERKLKEIDRELQKKKEE DMD_MOUSE DMD_MOUSE SQRRKKALEISHQWYQYKRQADDLLKCLDEIEKKLASLPEPRDERKLKEIDRELQKKKEE DMD_PIG DMD_PIG SQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPQDEKKIKEIDRELQKKKEE DMD_HUMAN DMD_HUMAN SQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEE DMD_CANFA DMD_CANFA SQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEE Q4S6Z2_TETNG Q4S6Z2_TETNG ----------------------------------------PSVEPN--DSSPAIVRRS-- O08614_MOUSE O08614_MOUSE ----------------------------------------PIQQRKTIPVSSGITSSA-- O55147_RAT O55147_RAT ----------------------------------------P--QRKTIPLSSGIMSSA-- Q5JCF5_CANFA Q5JCF5_CANFA ----------------------------------------PNQQRRTGQLAPGIRLSP-- UTRO_HUMAN UTRO_HUMAN ----------------------------------------PIQQRKMGQLASGIRSSL-- MATCH : . : CONSENSUS ????????????????????????????????????????P????K??????????????

DMD_CHICK DMD_CHICK LNAVNRQAERLSKDGAAKAVEPTLVQLSKRWRDFESKFAQFRRLNYAQIQTVLEDTTFVM A2A9Z0_MOUSE A2A9Z0_MOUSE LNAVRRQAEGLSENGAAMAVEPTQIQLSKRWRQIESNFAQFRRLNFAQIHTLHEETMVVT DMD_MOUSE DMD_MOUSE LNAVRRQAEGLSENGAAMAVEPTQIQLSKRWRQIESNFAQFRRLNFAQIHTLHEETMVVT DMD_PIG DMD_PIG LDAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAHFRRLNFAQIHTVHEESVMVM DMD_HUMAN DMD_HUMAN LNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVM DMD_CANFA DMD_CANFA LNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVHEESVVAM Q4S6Z2_TETNG Q4S6Z2_TETNG ------------------------------------------------------------ O08614_MOUSE O08614_MOUSE ------------------------------------------------------------ O55147_RAT O55147_RAT ------------------------------------------------------------ Q5JCF5_CANFA Q5JCF5_CANFA ------------------------------------------------------------ UTRO_HUMAN UTRO_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

DMD_CHICK DMD_CHICK TESMTVETTYVPSTYLAEILQLLQALSEVEERLNSPVLQAKDCEDLLKQEECLKNIKDCL A2A9Z0_MOUSE A2A9Z0_MOUSE TEDMPLDVSYVPSTYLTEISHILQALSEVDHLLNTPELCAKDFEDLFKQEESLKNIKDNL DMD_MOUSE DMD_MOUSE TEDMPLDVSYVPSTYLTEISHILQALSEVDHLLNTPELCAKDFEDLFKQEESLKNIKDNL DMD_PIG DMD_PIG TEDMPLEISYVPSAYLTEITHVSQALSEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSL DMD_HUMAN DMD_HUMAN TEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSL DMD_CANFA DMD_CANFA TEDMPLEISYVPSTYLTEITHVSQALSEVEELLNAPDLCAQDFEDLFKQEESLKNIKDSL Q4S6Z2_TETNG Q4S6Z2_TETNG -----------PSDYLVDINKVLLAMADNELLLNSSELSGGLYEDFSSQEDTLKNIKDNL O08614_MOUSE O08614_MOUSE ----------LPADYLVEINKILLTLDDIELSLNMPELNTTVYKDFSFQEDSLKSIKGQL O55147_RAT O55147_RAT ----------LPADYLVEINKILLTLDDIELSLNIPELNTTVYEDFSFQEDSLKRIKDQL Q5JCF5_CANFA Q5JCF5_CANFA ----------LPTDYLVEISKVLLSMDDAELSLNAPELSTVVYEDFSFQEDSLKNIKEQL UTRO_HUMAN UTRO_HUMAN ----------LPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQL MATCH *: **.:* :: : : : ** . * :*: **: ** ** * CONSENSUS ???????????P??YL?EI??????????E??LN?P?L?????ED???QE?SLKNIKD?L

DMD_CHICK DMD_CHICK GRLQGHIDIIHSKKTPALQSATPRETANIQDKLTQLNSQWEKVNKMYRDRQARFDKSKEK A2A9Z0_MOUSE A2A9Z0_MOUSE QQISGRIDIIHKKKTAALQSATSMEKVKVQEAVAQMDFQGEKLHRMYKERQGRFDRSVEK DMD_MOUSE DMD_MOUSE QQISGRIDIIHKKKTAALQSATSMEKVKVQEAVAQMDFQGEKLHRMYKERQGRFDRSVEK DMD_PIG DMD_PIG QQISGRVDIIHNKKTAGLQSATPVERTRLQEALSQLDFQWERVNKMYKDRQGKFDRSVEK DMD_HUMAN DMD_HUMAN QQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEK DMD_CANFA DMD_CANFA QQISGRIDIIHNKKTAALHSATPAERAKLQEALSRLDFQWERVNNMYKDRQGRFDRSVEK Q4S6Z2_TETNG Q4S6Z2_TETNG ESLGEQVTGIHERQPDAIRDASPAEVAQISDALTQLNAEWDRLNRMYNHRKGSFDCAVEE O08614_MOUSE O08614_MOUSE DRLGEQIAVVHEKQPDVIVEASGPEAIQIRDMLAQLNAKWDRVNRVYSDRRGSFARAVEE O55147_RAT O55147_RAT DRLGEQLAAVHEKQPDVILEASGPEAIQIRDMLSQLNAKWDRVNRLYSDRRGSFARAVEE Q5JCF5_CANFA Q5JCF5_CANFA DKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYNDRKSHFDRAVEE UTRO_HUMAN UTRO_HUMAN DKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEE MATCH :: :*.::. : .*: * .: : ::::: : ::::.:* .*:. * : *: CONSENSUS ?????????IH?K???????A???E???????L?QL???W???N?MY??R?G?FDR?VE?

DMD_CHICK DMD_CHICK WRLFHCEMKSFNEWLTETEEKLSRAQIEAGDVGHVKTKQFLQELQDGIGRQQTVVKTLNV A2A9Z0_MOUSE A2A9Z0_MOUSE WRHFHYDMKVFNQWLNEVEQFFKKTQNPE-NWEHAKYKWYLKELQDGIGQRQAVVRTLNA DMD_MOUSE DMD_MOUSE WRHFHYDMKVFNQWLNEVEQFFKKTQNPE-NWEHAKYKWYLKELQDGIGQRQAVVRTLNA DMD_PIG DMD_PIG WRRFHYDMKIFNQWLTEAEHFLKKTQIPE-NWEHAKYKWYLKELQDGIGQRQTIVRVLNA DMD_HUMAN DMD_HUMAN WRRFHYDIKIFNQWLTEAEQFLRKTQIPE-NWEHAKYKWYLKELQDGIGQRQTVVRTLNA DMD_CANFA DMD_CANFA WRRFHYDMKILNQWLTEAEQFLKKTQIPE-NWEHAKYKWYLKELQDGIGQRQSVVRVLNA Q4S6Z2_TETNG Q4S6Z2_TETNG WRQFHCDMNDLSQWLTDTERLVSESVGPDGRLDLDSARQRQEELEEGLTSHQPVT----- O08614_MOUSE O08614_MOUSE WRQFHHDLDDLTQWLSEAEDLLVDTCAPDGSLDLEKARAQQLELEEGLSSHQPSLIKVNR O55147_RAT O55147_RAT WKQFHCDLDDLTQWLSEAEDLLVGTCAPDGSLDLEKARTHQLELEDGLSSHQPCLIDVNQ Q5JCF5_CANFA Q5JCF5_CANFA WRQFHCDLNDLTQWITEAEELLAESFTPDGGLDLEKARMHQQELEEGISSHQPSFAALNR UTRO_HUMAN UTRO_HUMAN WRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNR MATCH *: ** ::. :.:*:.:.* . : . : **: *: :*. CONSENSUS WR?FH?D?????QWL?E?E????????P???????K??????EL??G????Q??????N?

DMD_CHICK DMD_CHICK TGEEIIEQSSAADANVLKEQLGNLNTRWQEICRQLVEKRKRIEEEKNILSEFQEDLNKLI A2A9Z0_MOUSE A2A9Z0_MOUSE TGEEIIQQSSKTDVNILQEKLGSLSLRWHDICKELAERRKRIEEQKNVLSEFQRDLNEFV DMD_MOUSE DMD_MOUSE TGEEIIQQSSKTDVNILQEKLGSLSLRWHDICKELAERRKRIEEQKNVLSEFQRDLNEFV DMD_PIG DMD_PIG TGEEVIQQSSKTDASILQEKLGSLNLRWQEVCKQLAERKKRLEEQKNILSEFQRDLNEFV DMD_HUMAN DMD_HUMAN TGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFV DMD_CANFA DMD_CANFA TGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLAERKKRLEEQKNILSEFQRDVNEFV Q4S6Z2_TETNG Q4S6Z2_TETNG --HELLDKIREVEANLQSH-------------TQFEDKMTRLTD---------------- O08614_MOUSE O08614_MOUSE KGEDLVQRLRPSEASFLKEKLAGFNQRWSTLVAEVEALQPRLKGESQQVLGYKRRLDEVT O55147_RAT O55147_RAT KGEDIVQRLRPSDASFLKDKLASLNQRWSALVAEVKDLQPRLKGESKQVSGYRKRLDEVV Q5JCF5_CANFA Q5JCF5_CANFA TGEGIVQKLSPTDGSFLKDKLAGLNQRWNAIFAEVKDRWPRLKGENKQVMEYRRRLGEIM UTRO_HUMAN UTRO_HUMAN TGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEII MATCH . :::: : .. .. :. *: CONSENSUS ?GE???Q?????D???L??KL??L??RW????????????R??????????????L?E??

DMD_CHICK DMD_CHICK LWLEETENVIAIPLEPGNEDQLRDCLGKVKLRVEELLPHKGILKRLNETGGTTLGSASLN A2A9Z0_MOUSE A2A9Z0_MOUSE LWLEEADNIAITPL--GDEQQLKEQLEQVKLLAEELPLRQGILKQLNETGGAVLVSAPIR DMD_MOUSE DMD_MOUSE LWLEEADNIAITPL--GDEQQLKEQLEQVKLLAEELPLRQGILKQLNETGGAVLVSAPIR DMD_PIG DMD_PIG LWLEEADNITSVALEPGNEQQLKEKLEEIKLLAEELPLRQGTLKQLNETGGTVLVSAPIS DMD_HUMAN DMD_HUMAN LWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPIS DMD_CANFA DMD_CANFA LWLEEADNVANIPLEPGNEQQLKEKLEQVKLLAEELPLRQGILKQLNETGGTVLVSAPLS Q4S6Z2_TETNG Q4S6Z2_TETNG -WVIVTHQTIITR---GLSSSQAQVLLKMGDLGIN---QTSSITHVVKRATCVVGPGGLH O08614_MOUSE O08614_MOUSE CWLTKVESAVQKR----STPDPEESPQELTDLAQETEVQAENIKWLNRAELEMLSDKNLS O55147_RAT O55147_RAT CWLTKVENSVQKR----STPDPEENPWELTDLAQEMDAQAENIKWLNRAELEMLSDKNLS Q5JCF5_CANFA Q5JCF5_CANFA CWLTEAENAMQKR----SAAELEENFQELTDLTQEMDVQAEKLKWLNRTELEMLSDKSLS UTRO_HUMAN UTRO_HUMAN CWLTKAEHAMQKR----STTELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLS MATCH *: .. . : :: : : :. : . : : CONSENSUS ?WL????????????????????E???????L??E????????K?LN??????L??????

DMD_CHICK DMD_CHICK PERKHKLESTLKEASRRLLKVSRDLPEKQKEIEILLKDFIE-------LNQQINQLTLWI A2A9Z0_MOUSE A2A9Z0_MOUSE PEEQDKLEKKLKQTNLQWIKVSRALPEKQGELEVHLKDFRQ-------LEEQLDHLLLWL DMD_MOUSE DMD_MOUSE PEEQDKLEKKLKQTNLQWIKVSRALPEKQGELEVHLKDFRQ-------LEEQLDHLLLWV DMD_PIG DMD_PIG PEEQDKIENKLKQTNLQWIKVSRILPEKQGEIEAHIKDLGQ-------FEEQLNHLLVWL DMD_HUMAN DMD_HUMAN PEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL DMD_CANFA DMD_CANFA PEEQDKLENKLKQTNLQWIKVSRNLPEKQEEIEAHVKDLGQ-------LEEQLNHLLLWL Q4S6Z2_TETNG Q4S6Z2_TETNG ERPEKGPGGPVGSFH-------RAAKT--------------------------------- O08614_MOUSE O08614_MOUSE LREREKLSESLKNVNTTWTKVCREVPS--------------------------------- O55147_RAT O55147_RAT LCERDNLSESLRNVNTMWTKICREVPS--------------------------------- Q5JCF5_CANFA Q5JCF5_CANFA LHEREKISESLRIVNSTWNKICREVPS--------------------------------- UTRO_HUMAN UTRO_HUMAN LPERDKISESLRTVNMTWNKICREVPT--------------------------------- MATCH .. : * CONSENSUS ??E??K????L???N??W?K??R??P??????????????????????????????????

DMD_CHICK DMD_CHICK TPVKNQLELYNQVGQPGAFDIKETEAAVQAKQPNVEEVLSKGCHLYKEKPATHPVKKKLE A2A9Z0_MOUSE A2A9Z0_MOUSE SPIRNQLEIYNQPSQAGPFDIKEIEVTVHGKQADVERLLSKGQHLYKEKPSTQPVKRKLE DMD_MOUSE DMD_MOUSE SPIRNQLEIYNQPSQAGPFDIKEIEVTVHGKQADVERLLSKGQHLYKEKPSTQPVKRKLE DMD_PIG DMD_PIG SPIKNQLEIYNQPNQTGPFDIKETEVAVQAKQLDVEGILSKGQHLYKEKPATQPVKRKLE DMD_HUMAN DMD_HUMAN SPIRNQLEIYNQPNQEGPFDVKETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE DMD_CANFA DMD_CANFA SPIRNQLEIYNQPNQTGPFDIKEIEVAVQAKQPDVEGILSKGQHLYKEKPATQPAKRKLE Q4S6Z2_TETNG Q4S6Z2_TETNG ------------------------------------------------------------ O08614_MOUSE O08614_MOUSE ------------------------------------------------------------ O55147_RAT O55147_RAT ------------------------------------------------------------ Q5JCF5_CANFA Q5JCF5_CANFA ------------------------------------------------------------ UTRO_HUMAN UTRO_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

DMD_CHICK DMD_CHICK DLNADWKAINHLILQLKEKPTFGEPALTSPGVLTSGQTVAVDTQARVTKETTSFTPEMPS A2A9Z0_MOUSE A2A9Z0_MOUSE DLRSEWEAVNHLLRELRTKQPDRAPGLSTTGA-SASQTVTLVTQSVVTKETVISKLEMPS DMD_MOUSE DMD_MOUSE DLRSEWEAVNHLLRELRTKQPDRAPGLSTTGA-SASQTVTLVTQSVVTKETVISKLEMPS DMD_PIG DMD_PIG DLSSEWKAVTHLLQELRAKWPGPTPGLTTIEA-PTSQTVTLVTQPTVTKETAISKPEMPS DMD_HUMAN DMD_HUMAN DLSSEWKAVNRLLQELRAKQPDLAPGLTTIGA-SPTQTVTLVTQPVVTKETAISKLEMPS DMD_CANFA DMD_CANFA DLSSDWKVVTQLLQELRAKQPGPAPGLTTVRA-PPSQTVTLVTQPAVTKETAISKLEMPS Q4S6Z2_TETNG Q4S6Z2_TETNG ------------TAVVASREVSAVP--------SAVQTVTLVS----------EEPHHQR O08614_MOUSE O08614_MOUSE ------------LLKTRTQDPCSAPQMRMAAH-PNVQKVVLVSSA--------SDAPLRG O55147_RAT O55147_RAT ------------LLKTRTQDPCSAPQTRIAAH-PNVQKVALVSSA--------SDAPLRG Q5JCF5_CANFA Q5JCF5_CANFA ------------TLKEHIQEPCSVSQTRIAAH-PGVQKVVLVSSA--------SDIPVQS UTRO_HUMAN UTRO_HUMAN ------------TLKECIQEPSSVSQTRIAAH-PNVQKVVLVSSA--------SDIPVQS MATCH : . . *.*.: : CONSENSUS ????????????????????P???P???????????Q?V?LV???????????S??????

DMD_CHICK DMD_CHICK SVLLEVPALADFNKAWAELTDWLSRLDREIKAQRVTVGDLDDINDMIIKQKANMQDLEQR A2A9Z0_MOUSE A2A9Z0_MOUSE SLLLEVPALADFNRAWTELTDWLSLLDRVIKSQRVMVGDLEDINEMIIKQKATLQDLEQR DMD_MOUSE DMD_MOUSE SLLLEVPALADFNRAWTELTDWLSLLDRVIKSQRVMVGDLEDINEMIIKQKATLQDLEQR DMD_PIG DMD_PIG SLLLEVPALADFNRAWTELTDWLSLLDRVIKSQRVMVGDLEDINEMIIKQKATLQDLEQR DMD_HUMAN DMD_HUMAN SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR DMD_CANFA DMD_CANFA SLLLEVPALADFNRAWTELTDWLSLLDRVIKSQRVMVGDLEDINEMIIKQKATLQDLEQR Q4S6Z2_TETNG Q4S6Z2_TETNG PHTPDSVAPTDLNKTATELSDWLVLITQMLKSNIVTVGDIGEIRTTMGRLQVTKSDLEQR O08614_MOUSE O08614_MOUSE G--LEISVPADLDKTITELADWLVLIDQMLKSNIVTVGDVKEINKTVSRMKITKADLEQR O55147_RAT O55147_RAT P---EISVPADLDKTITELADWLVLIDQMLKSNIVTVGDVKEINKTVSRMKITKADLEQR Q5JCF5_CANFA Q5JCF5_CANFA PRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDIEEINKTVSRMKITKSDLEQR UTRO_HUMAN UTRO_HUMAN HRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQR MATCH : :*:::: :**:*** : : :*:: * ***: :*. : : : . ***** CONSENSUS ????E????AD?????TEL?DWL?L?D???KS??V?VGD???IN??????K?T??DLEQR

DMD_CHICK DMD_CHICK RPQLDELITAAQNLKNKTSNQEARTIITDRIEKIQSQWDDVHGYLQNRRQQLHEMQKDST A2A9Z0_MOUSE A2A9Z0_MOUSE RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQIQWDEVQEQLQNRRQQLNEMLKDST DMD_MOUSE DMD_MOUSE RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQIQWDEVQEQLQNRRQQLNEMLKDST DMD_PIG DMD_PIG RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQSQWDEVQEHLQNRRQQLNEMLKDST DMD_HUMAN DMD_HUMAN RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST DMD_CANFA DMD_CANFA RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQSQWDEVQEHLQNRRLQLTEMLKDST Q4S6Z2_TETNG Q4S6Z2_TETNG HHQLDDIFTLAQNIKNKTSNLDVRTSISEKLERVRSQWDSTQHGVEARLQQLDTMIGHSN O08614_MOUSE O08614_MOUSE HPQLDCVFTLAQNLKNKASSSDVRTAITEKLEKLKTQWESTQHGVELRRQQLEDMVVDSL O55147_RAT O55147_RAT HPQLDFVFTLAQNLKNKASSSDLRTAITGKLEKLKTQWESTQHGVELRRQQLEDMVVDSL Q5JCF5_CANFA Q5JCF5_CANFA HPQLDYVFTLAQNLKNKASSSDVRTAITEKLEKVKNQWDSTQHGVELRQQQLEDMIIDSI UTRO_HUMAN UTRO_HUMAN HPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSL MATCH : **: ::* ***:***:*. : ** *: ::*::: **: .: :: * ** * .* CONSENSUS ?PQL????T?AQNLKNK?S????RT?IT???E????QWD??Q?????R?QQL??M??DS?

DMD_CHICK DMD_CHICK QWLEAKQEAEQVLEQAKAKLESWKEISYTVEALKKQNSELKQFSKEIRQWQMNIEGVNDV A2A9Z0_MOUSE A2A9Z0_MOUSE QWLEAKEEAEQVIGQVRGKLDSWKEGPHTVDAIQKKITETKQLAKDLRQRQISVDVANDL DMD_MOUSE DMD_MOUSE QWLEAKEEAEQVIGQVRGKLDSWKEGPHTVDAIQKKITETKQLAKDLRQRQISVDVANDL DMD_PIG DMD_PIG QWLEAKEEAEQVLGQARAKLESWKEGPYTMDAIQRKITETKQLAKDLRQWQINVDVANDL DMD_HUMAN DMD_HUMAN QWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDL DMD_CANFA DMD_CANFA QWLEAKEEAEQVLGQARAKLESWKEAPYTVDAIQKKITETKQLAKDLRQWQINVDVANDL Q4S6Z2_TETNG Q4S6Z2_TETNG HWEEQRKQVKALIGHHEGRFHNLLQQAR--DPLTKQLADNKAFLQDLGQGQAPVASFNEL O08614_MOUSE O08614_MOUSE QWDDHREETEELMRKYEARFYMLQQARR--DPLSKQVSDNQLLLQELGSGDGVIMAFDNV O55147_RAT O55147_RAT QWDDHREETEELMRKHEARFYMLQQARR--DPLSKQVSDNQLLLQELGSGDGVIMAFDNV Q5JCF5_CANFA Q5JCF5_CANFA QWDDHKEETEELMRKYEARLYILQQARR--DPLIKQISDNQILLQELGPGDGIIMAFDNV UTRO_HUMAN UTRO_HUMAN QWDDHREETEELMRKYEARLYILQQARR--DPLTKQISDNQILLQELGPGDGIVMAFDNV MATCH :* : :::.: :: : ..:: : :.: :: :: : : ::: : : ::: CONSENSUS QW????EE?E????????????????????D???K???????L???L?????????????

DMD_CHICK DMD_CHICK ALKPVRDYSADDTRKVELMTDNINATWATINKRVSEREAALESALLMLQEFYLDLEKFLA A2A9Z0_MOUSE A2A9Z0_MOUSE ALKLLRDYSADDTRKVHMITENINTSWGNIHKRVSEQEAALEETHRLLQQFPLDLEKFLS DMD_MOUSE DMD_MOUSE ALKLLRDYSADDTRKVHMITENINTSWGNIHKRVSEQEAALEETHRLLQQFPLDLEKFLS DMD_PIG DMD_PIG ALKLLRDYSADDTRKVHMITENINASWANIHKRLSERETVLEETHRLLQQFPLDLEKFLA DMD_HUMAN DMD_HUMAN ALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLA DMD_CANFA DMD_CANFA ALKLLRDYSADDTRKVHMITENINASWASIHKRLSEREAALEETHRLLQQFPLDLEKFLA Q4S6Z2_TETNG Q4S6Z2_TETNG SAHLLHEYSGDDTRRIKEVTDKHNAVWNSINKRASDRHAHLDSELKGLQMSLRELETFLK O08614_MOUSE O08614_MOUSE LQKLLEEYSGDDTRNVEETTEYLKTSWVNLKQSIADRQSALEAELQTVQTSRRDLENFVK O55147_RAT O55147_RAT LQKLLEEYSSDDTRNVEETTEYLKTSWINLKQSIADRQSALEAELRTVQTSRRDLENFVK Q5JCF5_CANFA Q5JCF5_CANFA LQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSITDRQCALEAELRAVQASRRDLENFLK UTRO_HUMAN UTRO_HUMAN LQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLK MATCH : :.:*..****.:. *: :: * .::: :::. *: :* :**.*: CONSENSUS ??KLL??YS?DDTR?V???TE????SW?????????R??ALE??????Q????DLE?FL?

DMD_CHICK DMD_CHICK WLTEAETTANVLQDATHKEKTLEDPQMVRELMKQ-------------------------- A2A9Z0_MOUSE A2A9Z0_MOUSE WITEAETTANVLQDASRKEKLLEDSRGVRELMKP-------------------------- DMD_MOUSE DMD_MOUSE WITEAETTANVLQDASRKEKLLEDSRGVRELMKP-------------------------- DMD_PIG DMD_PIG WLTEAETTANVLQDATHKERLLEDSKGVRELMKQ-------------------------- DMD_HUMAN DMD_HUMAN WLTEAETTANVLQDATRKERLLEDSKGVKELMKQ-------------------------- DMD_CANFA DMD_CANFA WLTEAETTANVLQDATHKERLLEDSKGVRELMKQ-------------------------- Q4S6Z2_TETNG Q4S6Z2_TETNG WLQEAETTVNVLADASQREDLSQDTAHVKELRQQLEMMAMVRTSLQKVVVFLHRLQRMAI O08614_MOUSE O08614_MOUSE WLQEAETTANVLADASQRENALQDSVLARQLRQQ-------------------------- O55147_RAT O55147_RAT WLQEAETTANVLADASQRENALQDSVLARQLRQQ-------------------------- Q5JCF5_CANFA Q5JCF5_CANFA WIQEAETTVNVLADASQRENALQDTLLARELTQQ-------------------------- UTRO_HUMAN UTRO_HUMAN WIQEAETTVNVLVDASHRENALQDSILARELKQQ-------------------------- MATCH *: *****.*** **:::* :*. .::* : CONSENSUS W??EAETT?NVL?DA???E??L?D????REL??Q??????????????????????????

DMD_CHICK DMD_CHICK ------------------------------------------------------------ A2A9Z0_MOUSE A2A9Z0_MOUSE ------------------------------------------------------------ DMD_MOUSE DMD_MOUSE ------------------------------------------------------------ DMD_PIG DMD_PIG ------------------------------------------------------------ DMD_HUMAN DMD_HUMAN ------------------------------------------------------------ DMD_CANFA DMD_CANFA ------------------------------------------------------------ Q4S6Z2_TETNG Q4S6Z2_TETNG SSPRYQKLCKPDNQSVEQQSLELRPDVVPPCQYLWMICPRAVIYHRDVLDSSKDVVFFRN O08614_MOUSE O08614_MOUSE ------------------------------------------------------------ O55147_RAT O55147_RAT ------------------------------------------------------------ Q5JCF5_CANFA Q5JCF5_CANFA ------------------------------------------------------------ UTRO_HUMAN UTRO_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

DMD_CHICK DMD_CHICK -----------------------WQDLQAEIDAHTDIFHNLDENGQKILRSLEGSEDAVL A2A9Z0_MOUSE A2A9Z0_MOUSE -----------------------WQDLQGEIETHTDIYHNLDENGQKILRSLEGSDEAPL DMD_MOUSE DMD_MOUSE -----------------------WQDLQGEIETHTDIYHNLDENGQKILRSLEGSDEAPL DMD_PIG DMD_PIG -----------------------WQDLQGEIEAHTDIYHNLDENGQKILRSLEGSDDAIL DMD_HUMAN DMD_HUMAN -----------------------WQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVL DMD_CANFA DMD_CANFA -----------------------WQDLQGEIEAHTDIYHNLDENGQKVLRSLEGSDDAAL Q4S6Z2_TETNG Q4S6Z2_TETNG YRITVMYWFNYTGCYRQVVPLDDLQDIQAEIDAHNDIYKSVEGNKSKMVKALGSSEEAAF O08614_MOUSE O08614_MOUSE -----------------------MLDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATM O55147_RAT O55147_RAT -----------------------MLDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATM Q5JCF5_CANFA Q5JCF5_CANFA -----------------------MQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATM UTRO_HUMAN UTRO_HUMAN -----------------------MQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATM MATCH *:*.**::*.*:::.:: * .*::::* .*::* : CONSENSUS ????????????????????????QD?Q?EI?AH?DI????D?N?QK????L??S??A??

DMD_CHICK DMD_CHICK LQRRLDNMNFRWSELRKKSLNI-------------------RSHLEASTDQWKRLHLSLQ A2A9Z0_MOUSE A2A9Z0_MOUSE LQRRLDNMNFKWSELQKKSLNI-------------------RSHLEASSDQWKRLHLSLQ DMD_MOUSE DMD_MOUSE LQRRLDNMNFKWSELQKKSLNI-------------------RSHLEASSDQWKRLHLSLQ DMD_PIG DMD_PIG LQRRLDNMNFKWSELRKKSLNI-------------------RSHLEASSDQWKRLHLSLQ DMD_HUMAN DMD_HUMAN LQRRLDNMNFKWSELRKKSLNI-------------------RSHLEASSDQWKRLHLSLQ DMD_CANFA DMD_CANFA LQRRLDNMNFKWSELRKKSLNI-------------------RSHLEASSDQWKRLHLSLQ Q4S6Z2_TETNG Q4S6Z2_TETNG LQHRLDDMNQRWNDLKAKSASISFCAFQTSNHRTIKNVCIGRAHLEASAERWSRLLGLLE O08614_MOUSE O08614_MOUSE LQHRLDDMNQRWNDLKAKSASI-------------------RAHLEASAEKWNRLLASLE O55147_RAT O55147_RAT LQHRLDDMNQRWNDLKAKSASI-------------------RAHLEASAEKWNRLLASLE Q5JCF5_CANFA Q5JCF5_CANFA LQHRLDDMNQRWNDLKAKSASI-------------------RAHLEASAEKWNRLLTSLE UTRO_HUMAN UTRO_HUMAN LQHRLDDMNQRWNDLKAKSASI-------------------RAHLEASAEKWNRLLMSLE MATCH **:***:** :*.:*: ** .* *:*****:::*.** *: CONSENSUS LQ?RLD?MN??W??L??KS??I???????????????????R?HLEAS???W?RL??SL?

DMD_CHICK DMD_CHICK ELLAWLQLKEDELKQQAPIGGDIPTVQKQNDVHRTFKRELKTKEPVIMNALETVRLFLAD A2A9Z0_MOUSE A2A9Z0_MOUSE ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDIHRAFKRELKTKEPVIMSTLETVRIFLTE DMD_MOUSE DMD_MOUSE ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDIHRAFKRELKTKEPVIMSTLETVRIFLTE DMD_PIG DMD_PIG ELLVWLQLKDDELSRQAPIGGDCPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE DMD_HUMAN DMD_HUMAN ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE DMD_CANFA DMD_CANFA ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE Q4S6Z2_TETNG Q4S6Z2_TETNG ELWRWICMKDEDLAKQMPVGGDVPTLLQQQSYCTALQSELKEREHLVVSTLDQARMFLAD O08614_MOUSE O08614_MOUSE ELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKVLRRELKEKEYSVLNAVDQARVFLAD O55147_RAT O55147_RAT ELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKVLRRELKEKEYSVLNAVDQARVFLAD Q5JCF5_CANFA Q5JCF5_CANFA ELIKWLNIKDEELQNQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAIDQARVFLAD UTRO_HUMAN UTRO_HUMAN ELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLAD MATCH ** *: :*:::* .* *:*** *:: * . .:: *** :* ::.::: .*:**:: CONSENSUS EL??WL??KD?EL??Q?PIGGD?PA?Q?Q?D??????RELK?KE??????????R?FL??

DMD_CHICK DMD_CHICK QPVEGLEKVYPEPR---DLSPEERAQNVTKVLRRQADDVRTEWDKLNLRSADWQKKIDDA A2A9Z0_MOUSE A2A9Z0_MOUSE QPLEGLEKLYQEPR---ELPPEERAQNVTRLLRKQAEEVNAEWDKLNLRSADWQRKIDEA DMD_MOUSE DMD_MOUSE QPLEGLEKLYQEPR---ELPPEERAQNVTRLLRKQAEEVNAEWDKLNLRSADWQRKIDEA DMD_PIG DMD_PIG QPLEGLEKLYQEPR---ELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDEA DMD_HUMAN DMD_HUMAN QPLEGLEKLYQEPR---ELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDET DMD_CANFA DMD_CANFA QPLEGLEKLYQEPR---ELPPEERAQNVTRLLRKQAEEVNTQWEKLNVHSADWQRKIDEA Q4S6Z2_TETNG Q4S6Z2_TETNG QPIEGPGEPRKTLQPKPDLTPEEKARGLARAIRKQTGEVRERWERLKGHISGWQSQVDQA O08614_MOUSE O08614_MOUSE QPIEAPEEPRRNPQSKTELTPEERAQKIAKAMRKQSSEVREKWENLNAVTSNWQKQVGKA O55147_RAT O55147_RAT QPIEAPEEPRRNPQSKTELTPEERAQKIAKAMRKQSSEVREKWESLNAVTSTWQKQVGKA Q5JCF5_CANFA Q5JCF5_CANFA QPIEAPEEPRRDLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKA UTRO_HUMAN UTRO_HUMAN QPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKA MATCH **:*. : : :*.***:*: ::: :*:*: :*. .*: *: : ** ::..: CONSENSUS QP?E??E??????????EL?PEERAQ??????RKQ??EV???W??LN?????WQ???D?A

DMD_CHICK DMD_CHICK LERLQGLQEAMDELDLKLRQAEAFKGSWQPVGDLLIDSLQDHLEKVKVYRAEMVPLKEKV A2A9Z0_MOUSE A2A9Z0_MOUSE LERLQELQEAADELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENV DMD_MOUSE DMD_MOUSE LERLQELQEAADELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENV DMD_PIG DMD_PIG LERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEKAPLKENV DMD_HUMAN DMD_HUMAN LERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENV DMD_CANFA DMD_CANFA LERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEITPLKENV Q4S6Z2_TETNG Q4S6Z2_TETNG LERLQELQSSMDQLDLRLTQAEEAKATWQPVGDLLIDALQDHIDKTVAFREEIAPLRQDV O08614_MOUSE O08614_MOUSE LEKLRDLQGAMDDLDADMKEVEAVRNGWKPVGDLLIDSLQDHIEKTLAFREEIAPINLKV O55147_RAT O55147_RAT LEKLRDLQGAVDDLDADMKEVEAVRNGWKPVGDLLIDSLQDHIEKTLAFREEIAPINLKV Q5JCF5_CANFA Q5JCF5_CANFA LEKLRDLQGAMDDLDVDMKEAEAVRNGWKPVGDLLIDSLQDHIEKTMAFREEIAPINLKV UTRO_HUMAN UTRO_HUMAN LEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKV MATCH **:*: ** : *:** : :.* : *:********:****::* . * * .*:. .* CONSENSUS LE?L??LQ?A?D?LD?????AE?????W?PVGDLLIDSLQDH?EK??A?R?EIAP????V

DMD_CHICK DMD_CHICK HQVNELAHRFAPPDIQLSPYTLSCLEDLNTRWKVLQVAIDERIRQLHEAHRDFGPTSQHF A2A9Z0_MOUSE A2A9Z0_MOUSE NRVNDLAHQLTTLGIQLSPYNLSTLEDLNTRWRLLQVAVEDRVRQLHEAHRDFGPASQHF DMD_MOUSE DMD_MOUSE NRVNDLAHQLTTLGIQLSPYNLSTLEDLNTRWRLLQVAVEDRVRQLHEAHRDFGPASQHF DMD_PIG DMD_PIG SHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRIRQLHEAHRDFGPASQHF DMD_HUMAN DMD_HUMAN SHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHF DMD_CANFA DMD_CANFA SYVNDLARQLTTLGIQLSPYNLNTLEDLNTRWKLLQVAIEDRIRQLHEAHRDFGPASQHF Q4S6Z2_TETNG Q4S6Z2_TETNG RVVNELSAELTPLDIQLSSTASRQLDQLNMRWKLLQVAVEDRLKLLQEAHRDFGPSSQHF O08614_MOUSE O08614_MOUSE KTMNDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHF O55147_RAT O55147_RAT KTMNDLSSQLSPLDLHPSPKMSRQLDDLNMRWKLLQVSVEDRLKQLQEAHRDFGPCSQHF Q5JCF5_CANFA Q5JCF5_CANFA KTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDLGPSSQHF UTRO_HUMAN UTRO_HUMAN KTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHF MATCH :*:*: .::. .:: * *::** **::***::::*:: *:*****:** **** CONSENSUS ??VNDL??QL??L????S??????L?DLN?RWKLLQV?V?DR??QL?EAHRDFGP?SQHF

DMD_CHICK DMD_CHICK LTTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKL A2A9Z0_MOUSE A2A9Z0_MOUSE LSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKL DMD_MOUSE DMD_MOUSE LSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKL DMD_PIG DMD_PIG LSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKL DMD_HUMAN DMD_HUMAN LSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKL DMD_CANFA DMD_CANFA LSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKL Q4S6Z2_TETNG Q4S6Z2_TETNG LSTSVQLPWQRAVSQNKVPYYINHQTQTTCWDHPKMTELYQTLADLNNVRFSAYRTAMKI O08614_MOUSE O08614_MOUSE LSTSVQLPWQRSISHNKVPYYINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYRTAIKI O55147_RAT O55147_RAT LSTSVQLPWQRSISHNKVPYYINHQTQTTCWDHPKMTELFQSLGDLNNVRFSAYRTAIKI Q5JCF5_CANFA Q5JCF5_CANFA LSTSVQLPWQRSISHNKVPYYINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYRTAIKI UTRO_HUMAN UTRO_HUMAN LSTSVQLPWQRSISHNKVPYYINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYRTAIKI MATCH *:**** **:*::* *********:**************:*:*.*************:*: CONSENSUS LSTSVQ?PW?R?IS?NKVPYYINH?TQTTCWDHPKMTEL?QSLADLNNVRFSAYRTA?K?

DMD_CHICK DMD_CHICK RRLQKALCLDLLNLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVP A2A9Z0_MOUSE A2A9Z0_MOUSE RRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVP DMD_MOUSE DMD_MOUSE RRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVP DMD_PIG DMD_PIG RRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTVYDRLEQEHNNLVNVP DMD_HUMAN DMD_HUMAN RRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVP DMD_CANFA DMD_CANFA RRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQVINCLTTIYDRLEQEHNNLVNVP Q4S6Z2_TETNG Q4S6Z2_TETNG RRLQKALCLDLLDLNVAQNTFKQHKLTNNSQLLSVPDIINCLTSIYDGLEQEHKDLVNVP O08614_MOUSE O08614_MOUSE RRLQKALCLDLLELNTTNEVFKQHKLNQNDQLLSVPDVINCLTTTYDGLEQLHKDLVNVP O55147_RAT O55147_RAT RRLQKALCLDLLELNTTNEVFKQHKLNQNDQLLSVPDVINCLTTTYDGLEQLHKDLVNVP Q5JCF5_CANFA Q5JCF5_CANFA RRLQKALCLDLLELNTTNEVFKQHKLNQNDQLLSVPDVINCLTTTYDGLEQMHMDLVNVP UTRO_HUMAN UTRO_HUMAN RRLQKALCLDLLELSTTNEIFKQHKLNQNDQLLSVPDVINCLTTTYDGLEQMHKDLVNVP MATCH ************.*..: : :.**:*.:*.* :.: ::*****: ** *** * :***** CONSENSUS RRLQKALCLDLL?L????????QH?L?QNDQ???????INCLTT?YD?LEQ?H??LVNVP

DMD_CHICK DMD_CHICK LCVDMCLNWLLNVYDTGRTGRIRVLSFKTGVVSLCKAHLEDKYRYLFKQVASSTGFCDQR A2A9Z0_MOUSE A2A9Z0_MOUSE LCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQR DMD_MOUSE DMD_MOUSE LCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQR DMD_PIG DMD_PIG LCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIVSLCKAHLEDKYRYLFKQVASSTGFCDQR DMD_HUMAN DMD_HUMAN LCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQR DMD_CANFA DMD_CANFA LCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQR Q4S6Z2_TETNG Q4S6Z2_TETNG LCVDMCLNWLLNVYDTGRSGKIRVLSMKIGLLSLCKGHLEEKYKYLFSQVASAGDTCDQR O08614_MOUSE O08614_MOUSE LCVDMCLNWLLNVYDTGRTGKIRVQSLKIGLMSLSKGLLEEKYRCLFKEVAGPTEMCDQR O55147_RAT O55147_RAT LCVDMCLNWLLNVYDTGRTGKIRVQSLKIGLMSLSKGLLEEKYRCLFKEVAGPTEMCDQR Q5JCF5_CANFA Q5JCF5_CANFA LCVDMCLNWLLNVYDTGRTGKIRVQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTEMCDQR UTRO_HUMAN UTRO_HUMAN LCVDMCLNWLLNVYDTGRTGKIRVQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTEMCDQR MATCH ******************:*:*** *:* *::**.*. **:**: **.:**.. **** CONSENSUS LCVDMCLNWLLNVYDTGRTG?IRV?S?K?G??SL?K??LE?KYRYLFK?VA??T??CDQR

DMD_CHICK DMD_CHICK RLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSM A2A9Z0_MOUSE A2A9Z0_MOUSE RLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSM DMD_MOUSE DMD_MOUSE RLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSM DMD_PIG DMD_PIG RLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSM DMD_HUMAN DMD_HUMAN RLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSM DMD_CANFA DMD_CANFA RLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSM Q4S6Z2_TETNG Q4S6Z2_TETNG QLGLLLHEAIQIPRQLGEVAAFGGSNIEPSVRSCFQHVNNKVELEPRQFVDWMRLEPQSM O08614_MOUSE O08614_MOUSE QLGLLLHDAIQIPRQLGEVAAFGGSNIEPSVRSCFQQNNNKPEISVKEFIDWMHLEPQSM O55147_RAT O55147_RAT QLGLLLHDAIQIPRQLGEVAAFGGSNIEPSVRSCFQQNNNKPEISVKEFIDWMRLEPQSM Q5JCF5_CANFA Q5JCF5_CANFA QLGLLLHDAIQIPRQLGEVAAFGGSNIEPSVRSCFQQNNNKPEISVKDFIDWMRLEPQSM UTRO_HUMAN UTRO_HUMAN QLGLLLHDAIQIPRQLGEVAAFGGSNIEPSVRSCFQQNNNKPEISVKEFIDWMHLEPQSM MATCH :******::***********:*************** *** *:. *:***:****** CONSENSUS ?LGLLLHD?IQIPRQLGEVA?FGGSNIEPSVRSCFQ??NNKPEI????F?DWMRLEPQSM

DMD_CHICK DMD_CHICK VWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKM A2A9Z0_MOUSE A2A9Z0_MOUSE VWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKM DMD_MOUSE DMD_MOUSE VWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKM DMD_PIG DMD_PIG VWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKM DMD_HUMAN DMD_HUMAN VWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKM DMD_CANFA DMD_CANFA VWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKM Q4S6Z2_TETNG Q4S6Z2_TETNG VWLPVLHRVAAAETAKHQAKCNICKECPIVGFR--------------------------- O08614_MOUSE O08614_MOUSE VWLPVLHRVAAAETAKHQAKCNICKECPIVGFRYRSLKHFNYDVCQSCFFSGRTAKGHKL O55147_RAT O55147_RAT VWLPV