Alignment of the gene Family HBG005739 of HOVERGEN

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Threshold: 50% 80% 100%
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Isoforms are ON
Q0V9Q1_XENTR Q0V9Q1_XENTR ------------------------------------------------------------ Q4SFA2_TETNG Q4SFA2_TETNG ------------------------------------------------------------ Q4TFI5_TETNG Q4TFI5_TETNG ------------------------------------------------------------ Q7SYM7_DANRE Q7SYM7_DANRE ------------------------------------------------------------ Q9DF20_DANRE Q9DF20_DANRE ------------------------------------------------------------ FMR1_XENTR FMR1_XENTR ------------------------------------------------------------ FMR1B_XENLA FMR1B_XENLA ------------------------------------------------------------ B7ZRL0_XENLA B7ZRL0_XENLA ------------------------------------------------------------ FMR1A_XENLA FMR1A_XENLA ------------------------------------------------------------ B6CVD8_TAEGU B6CVD8_TAEGU ------------------------------------------------------------ Q0II33_BOVIN Q0II33_BOVIN ------------------------------------------------------------ Q59GC1_HUMAN Q59GC1_HUMAN ------------------------------------------------------------ FMR1_PONAB FMR1_PONAB ------------------------------------------------------------ FMR1_HUMAN FMR1_HUMAN ------------------------------------------------------------ A8MQB8_HUMAN A8MQB8_HUMAN ------------------------------------------------------------ A6NNH4_HUMAN A6NNH4_HUMAN ------------------------------------------------------------ Q8IXW7_HUMAN Q8IXW7_HUMAN ------------------------------------------------------------ Q547R0_MOUSE Q547R0_MOUSE ------------------------------------------------------------ FMR1_MOUSE FMR1_MOUSE ------------------------------------------------------------ FMR1_RAT FMR1_RAT ------------------------------------------------------------ Q6AXB7_MOUSE Q6AXB7_MOUSE ------------------------------------------------------------ Q8BPK8_MOUSE Q8BPK8_MOUSE ------------------------------------------------------------ Q8BPN5_MOUSE Q8BPN5_MOUSE ------------------------------------------------------------ Q8VD80_RAT Q8VD80_RAT ------------------------------------------------------------ Q4T116_TETNG Q4T116_TETNG ------------------------------------------------------------ Q6NY99_DANRE Q6NY99_DANRE ------------------------------------------------------------ Q7ZV52_DANRE Q7ZV52_DANRE ------------------------------------------------------------ FXR2_MOUSE FXR2_MOUSE ------------------------------------------------------------ FXR2_HUMAN FXR2_HUMAN ------------------------------------------------------------ Q86V09_HUMAN Q86V09_HUMAN ------------------------------------------------------------ B1H2A6_RAT B1H2A6_RAT ------------------------------------------------------------ Q3TA75_MOUSE Q3TA75_MOUSE RQQGEVEAVERQRRVPGPRQQRGRRRAEAEVTKAAAAAAAVSLTVAETKAAAAAADGERP Q6P5B5_MOUSE Q6P5B5_MOUSE ------------------------------------------------------------ Q4T723_TETNG Q4T723_TETNG ------------------------------------------------------------ Q4TCM9_TETNG Q4TCM9_TETNG ------------------------------------------------------------ Q9PUN3_DANRE Q9PUN3_DANRE ------------------------------------------------------------ Q6NUW6_DANRE Q6NUW6_DANRE ------------------------------------------------------------ Q7SXA0_DANRE Q7SXA0_DANRE ------------------------------------------------------------ Q4TCP2_TETNG Q4TCP2_TETNG ------------------------------------------------------------ FXR1B_XENLA FXR1B_XENLA ------------------------------------------------------------ A3KMH8_XENLA A3KMH8_XENLA ------------------------------------------------------------ FXR1A_XENLA FXR1A_XENLA ------------------------------------------------------------ FXR1_XENTR FXR1_XENTR ------------------------------------------------------------ Q0VFT5_XENTR Q0VFT5_XENTR ------------------------------------------------------------ Q5F3S6_CHICK Q5F3S6_CHICK ------------------------------------------------------------ FXR1_CRIGR FXR1_CRIGR ------------------------------------------------------------ FXR1_MOUSE FXR1_MOUSE ------------------------------------------------------------ FXR1_BOVIN FXR1_BOVIN ------------------------------------------------------------ B4DM78_HUMAN B4DM78_HUMAN ------------------------------------------------------------ B4DXZ6_HUMAN B4DXZ6_HUMAN ------------------------------------------------------------ FXR1_HUMAN FXR1_HUMAN ------------------------------------------------------------ Q4R9A3_MACFA Q4R9A3_MACFA ------------------------------------------------------------ Q4R3K8_MACFA Q4R3K8_MACFA ------------------------------------------------------------ B4DGH9_HUMAN B4DGH9_HUMAN ------------------------------------------------------------ Q5R8Z2_PONAB Q5R8Z2_PONAB ------------------------------------------------------------ A6QLG6_BOVIN A6QLG6_BOVIN ------------------------------------------------------------ Q5R8Y7_PONAB Q5R8Y7_PONAB ------------------------------------------------------------ B4DM21_HUMAN B4DM21_HUMAN ------------------------------------------------------------ FXR1_RAT FXR1_RAT ------------------------------------------------------------ Q8C7U4_MOUSE Q8C7U4_MOUSE ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q0V9Q1_XENTR Q0V9Q1_XENTR -----------------------------------------MLSTLGKAMARGDLPFILP Q4SFA2_TETNG Q4SFA2_TETNG ------------------------------------------------------------ Q4TFI5_TETNG Q4TFI5_TETNG ------------------------------------------------------------ Q7SYM7_DANRE Q7SYM7_DANRE ------------------------------------------------------------ Q9DF20_DANRE Q9DF20_DANRE ------------------------------------------------------------ FMR1_XENTR FMR1_XENTR ------------------------------------------------------------ FMR1B_XENLA FMR1B_XENLA ------------------------------------------------------------ B7ZRL0_XENLA B7ZRL0_XENLA ------------------------------------------------------------ FMR1A_XENLA FMR1A_XENLA ------------------------------------------------------------ B6CVD8_TAEGU B6CVD8_TAEGU ------------------------------------------------------------ Q0II33_BOVIN Q0II33_BOVIN ------------------------------------------------------------ Q59GC1_HUMAN Q59GC1_HUMAN ------------------------------------------------------------ FMR1_PONAB FMR1_PONAB ------------------------------------------------------------ FMR1_HUMAN FMR1_HUMAN ------------------------------------------------------------ A8MQB8_HUMAN A8MQB8_HUMAN ------------------------------------------------------------ A6NNH4_HUMAN A6NNH4_HUMAN ------------------------------------------------------------ Q8IXW7_HUMAN Q8IXW7_HUMAN ------------------------------------------------------------ Q547R0_MOUSE Q547R0_MOUSE ------------------------------------------------------------ FMR1_MOUSE FMR1_MOUSE ------------------------------------------------------------ FMR1_RAT FMR1_RAT ------------------------------------------------------------ Q6AXB7_MOUSE Q6AXB7_MOUSE ------------------------------------------------------------ Q8BPK8_MOUSE Q8BPK8_MOUSE ------------------------------------------------------------ Q8BPN5_MOUSE Q8BPN5_MOUSE ------------------------------------------------------------ Q8VD80_RAT Q8VD80_RAT ------------------------------------------------------------ Q4T116_TETNG Q4T116_TETNG ------------------------------------------------------------ Q6NY99_DANRE Q6NY99_DANRE ------------------------------------------------------------ Q7ZV52_DANRE Q7ZV52_DANRE ------------------------------------------------------------ FXR2_MOUSE FXR2_MOUSE -----------------------------------------------------------M FXR2_HUMAN FXR2_HUMAN -----------------------------------------------------------M Q86V09_HUMAN Q86V09_HUMAN -----------------------------------------------------------M B1H2A6_RAT B1H2A6_RAT -----------------------------------------------------------M Q3TA75_MOUSE Q3TA75_MOUSE GPGPLLVGCSRAAVGPARLPPPAAPPPAPPPGRRRGPGPARTQGSVSAAAGPVGGGGGAM Q6P5B5_MOUSE Q6P5B5_MOUSE -----------------------------------------------------------M Q4T723_TETNG Q4T723_TETNG ------------------------------------------------------------ Q4TCM9_TETNG Q4TCM9_TETNG ------------------------------------------------------------ Q9PUN3_DANRE Q9PUN3_DANRE ------------------------------------------------------------ Q6NUW6_DANRE Q6NUW6_DANRE ------------------------------------------------------------ Q7SXA0_DANRE Q7SXA0_DANRE ------------------------------------------------------------ Q4TCP2_TETNG Q4TCP2_TETNG ------------------------------------------------------------ FXR1B_XENLA FXR1B_XENLA ------------------------------------------------------------ A3KMH8_XENLA A3KMH8_XENLA ------------------------------------------------------------ FXR1A_XENLA FXR1A_XENLA ------------------------------------------------------------ FXR1_XENTR FXR1_XENTR ------------------------------------------------------------ Q0VFT5_XENTR Q0VFT5_XENTR ------------------------------------------------------------ Q5F3S6_CHICK Q5F3S6_CHICK ------------------------------------------------------------ FXR1_CRIGR FXR1_CRIGR ------------------------------------------------------------ FXR1_MOUSE FXR1_MOUSE ------------------------------------------------------------ FXR1_BOVIN FXR1_BOVIN ------------------------------------------------------------ B4DM78_HUMAN B4DM78_HUMAN ------------------------------------------------------------ B4DXZ6_HUMAN B4DXZ6_HUMAN ------------------------------------------------------------ FXR1_HUMAN FXR1_HUMAN ------------------------------------------------------------ Q4R9A3_MACFA Q4R9A3_MACFA ------------------------------------------------------------ Q4R3K8_MACFA Q4R3K8_MACFA ------------------------------------------------------------ B4DGH9_HUMAN B4DGH9_HUMAN ------------------------------------------------------------ Q5R8Z2_PONAB Q5R8Z2_PONAB ------------------------------------------------------------ A6QLG6_BOVIN A6QLG6_BOVIN ------------------------------------------------------------ Q5R8Y7_PONAB Q5R8Y7_PONAB ------------------------------------------------------------ B4DM21_HUMAN B4DM21_HUMAN ------------------------------------------------------------ FXR1_RAT FXR1_RAT ------------------------------------------------------------ Q8C7U4_MOUSE Q8C7U4_MOUSE ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q0V9Q1_XENTR Q0V9Q1_XENTR MTKAKPQSNTDELEVEVRGTNGAFYQGFVRDIHKDAITVAVGNTWQAEKRIPFQDVRFPP Q4SFA2_TETNG Q4SFA2_TETNG ---------MDELVVEVRGASGAFYKAFVKDVQDGSVTVAFENNWQPERQMSVQDVRFPP Q4TFI5_TETNG Q4TFI5_TETNG ------------------------------------------------------------ Q7SYM7_DANRE Q7SYM7_DANRE ---------MDELAVEVRGASGAFYKAYIKDVHESTVTVAFENNWQPERQISFQDVRFPP Q9DF20_DANRE Q9DF20_DANRE ---------MDELAVEVRGASGAFYKAYIKDVHESTVTVAFENNWQPERQISFQDVRFPP FMR1_XENTR FMR1_XENTR ---------MEELAVEVRGSNGAFYKAFVKDVHEDSITVTFENNWQQERQIPFHDVRFPP FMR1B_XENLA FMR1B_XENLA ---------MEELAVEVRGSNGAFYKAFVKDVHEDSITVTFENNWQQEKQIPFHDVRFPP B7ZRL0_XENLA B7ZRL0_XENLA ---------MEELAVEVRGSNGAFYKAFMKDVHEDSITVTFENNWQQERQIPFHDVRFPP FMR1A_XENLA FMR1A_XENLA ---------MEELAVEVRGSNGAFYKAFMKDVHEDSITVTFENNWQQERQIPFHDVRFPP B6CVD8_TAEGU B6CVD8_TAEGU ---------MEELVVEVRGSNGAFYKAFVKDVHEDSITVSFENNWQPERQIPFHDVRFPP Q0II33_BOVIN Q0II33_BOVIN ---------MEDLVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPP Q59GC1_HUMAN Q59GC1_HUMAN ------------------------------------------------------------ FMR1_PONAB FMR1_PONAB ---------MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPP FMR1_HUMAN FMR1_HUMAN ---------MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPP A8MQB8_HUMAN A8MQB8_HUMAN ---------MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPP A6NNH4_HUMAN A6NNH4_HUMAN ---------MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPP Q8IXW7_HUMAN Q8IXW7_HUMAN ---------MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPP Q547R0_MOUSE Q547R0_MOUSE ---------MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPERQIPFHDVRFPP FMR1_MOUSE FMR1_MOUSE ---------MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPERQIPFHDVRFPP FMR1_RAT FMR1_RAT ---------MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPERQIPFHDVRFPP Q6AXB7_MOUSE Q6AXB7_MOUSE ---------MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPERQIPFHDVRFPP Q8BPK8_MOUSE Q8BPK8_MOUSE ---------MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPERQIPFHDVRFPP Q8BPN5_MOUSE Q8BPN5_MOUSE ---------MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPERQIPFHDVRFPP Q8VD80_RAT Q8VD80_RAT ---------MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQSERQIPFHDVRFPP Q4T116_TETNG Q4T116_TETNG ---------MDGLAVEVRGSNGAFYKGYVKDVHDDSLTIVFENNWQPERQLPFSDVRLPP Q6NY99_DANRE Q6NY99_DANRE ---------MDGLAVEVRGSNGAFYKGFIKDVHEDSLTIVFENNWQPERQLPFSDVRLPP Q7ZV52_DANRE Q7ZV52_DANRE ---------MDGLAVEVRGSNGAFYKGFIKDVHEDSLTIVFENNWQPERQLPFSDVRLPP FXR2_MOUSE FXR2_MOUSE GGLASGGDVEPGLPVEVRGSNGAFYKGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPP FXR2_HUMAN FXR2_HUMAN GGLASGGDVEPGLPVEVRGSNGAFYKGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPP Q86V09_HUMAN Q86V09_HUMAN GGLASGGDVEPGLPVEVRGSNGAFYKGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPP B1H2A6_RAT B1H2A6_RAT GGLASGGDVEPGLPVEVRGSNGAFYKGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPP Q3TA75_MOUSE Q3TA75_MOUSE GGLASGGDVEPGLPVEVRGSNGAFYKGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPP Q6P5B5_MOUSE Q6P5B5_MOUSE GGLASGGDVEPGLPVEVRGSNGAFYKGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPP Q4T723_TETNG Q4T723_TETNG ---------MEELAVEVRGSYGAYYKGFVKDIHNDSVTVAFENKWQQDRQVPFSDVRLPP Q4TCM9_TETNG Q4TCM9_TETNG --------------------------------------------WQQDRQVPFSDVRLPP Q9PUN3_DANRE Q9PUN3_DANRE ----------EELTVEVRGSNGAYYKGFVRDVHDDSLSISFENNWQPERQVPFSDVRLPP Q6NUW6_DANRE Q6NUW6_DANRE -------------TVEVRGSNGAYYKGFVRDVHDDSLSISFENNWQPERQVPFSDVRLPP Q7SXA0_DANRE Q7SXA0_DANRE ---------MEELTVEVRGSNGAYYKGFVRDVHDDSLSISFENNWQPERQVPFSDVRLPP Q4TCP2_TETNG Q4TCP2_TETNG ----------------------------------------FKFRWQQDRQVPFSDVRLPP FXR1B_XENLA FXR1B_XENLA ---------MEDLTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRMPP A3KMH8_XENLA A3KMH8_XENLA ---------MEDMTVEVRGSNGAFYKGFVKDVHEDSLTVVFENNWQPERQVPFDEVRMPP FXR1A_XENLA FXR1A_XENLA ---------MEDMTVEVRGSNGAFYKGFVKDVHEDSLTVVFENNWQPERQVPFDEVRMPP FXR1_XENTR FXR1_XENTR ---------MEDLAVEVRGSNGAYYKGFVKDVHEDSLTVVFENNWQPERQVPFHEVRMPP Q0VFT5_XENTR Q0VFT5_XENTR ---------MEDLAVEVRGSNGAYYKGFVKDVHEDSLTVVFENNWQPERQVPFHEVRMPP Q5F3S6_CHICK Q5F3S6_CHICK ---------MEELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPP FXR1_CRIGR FXR1_CRIGR ---------MADVTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPP FXR1_MOUSE FXR1_MOUSE ---------MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPP FXR1_BOVIN FXR1_BOVIN ---------MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPP B4DM78_HUMAN B4DM78_HUMAN ------------------------------------------------------------ B4DXZ6_HUMAN B4DXZ6_HUMAN ----------------------MVTEGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPP FXR1_HUMAN FXR1_HUMAN ---------MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPP Q4R9A3_MACFA Q4R9A3_MACFA ---------MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPP Q4R3K8_MACFA Q4R3K8_MACFA ------------------------------------------------------------ B4DGH9_HUMAN B4DGH9_HUMAN ------------------------------------------------------------ Q5R8Z2_PONAB Q5R8Z2_PONAB ---------MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPEHQVPFNEVRLPP A6QLG6_BOVIN A6QLG6_BOVIN ---------MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPP Q5R8Y7_PONAB Q5R8Y7_PONAB ---------MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPP B4DM21_HUMAN B4DM21_HUMAN ---------MAELTVEVRGSNGAFYK---------------------------------- FXR1_RAT FXR1_RAT ---------MAELTVEVRGSNGAFYKVFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPP Q8C7U4_MOUSE Q8C7U4_MOUSE ------------------------------------------------------------ MATCH CONSENSUS ??????????????VEVRG??GA?YK?F??DVH?DS?T??FENNWQ??RQ?PF??VR?PP

Q0V9Q1_XENTR Q0V9Q1_XENTR PPSYNRNISVGNEVE--------VYTRVNEKEPRCWWLAKVLKRMKENIVVAFTAYGNRY Q4SFA2_TETNG Q4SFA2_TETNG PPGFHKDISESDEVE--------VYSRPNEKEPCGWWPATVRMVKGEFYVIEYAACDATL Q4TFI5_TETNG Q4TFI5_TETNG ------------------------------------------------------------ Q7SYM7_DANRE Q7SYM7_DANRE PTGFQKEINESDEVE--------VYSRANDKEPCGWWLAKVRMVKGEFYVIEYAACDATL Q9DF20_DANRE Q9DF20_DANRE PTGFQKEINESDEVE--------VYSRANDKEPCGWWLAKVRMVKGEFYVIEYAACDATL FMR1_XENTR FMR1_XENTR PSGYNKDINESDEVE--------VYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATY FMR1B_XENLA FMR1B_XENLA PSGYNKDINESDEVE--------VYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATY B7ZRL0_XENLA B7ZRL0_XENLA PSGYNKDINESDEVE--------VYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATY FMR1A_XENLA FMR1A_XENLA PSGYNKDINERDEVE--------VYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATY B6CVD8_TAEGU B6CVD8_TAEGU PAGYNKDINESDEVE--------VYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATY Q0II33_BOVIN Q0II33_BOVIN PVGYNKDINESDEVE--------VYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATY Q59GC1_HUMAN Q59GC1_HUMAN -----------------------------------------LLFISQFYVIEYAACDATY FMR1_PONAB FMR1_PONAB PVGYNKDINESDEVE--------VYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATY FMR1_HUMAN FMR1_HUMAN PVGYNKDINESDEVE--------VYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATY A8MQB8_HUMAN A8MQB8_HUMAN PVGYNKDINESDEVE--------VYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATY A6NNH4_HUMAN A6NNH4_HUMAN PVGYNKDINESDEVE--------VYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATY Q8IXW7_HUMAN Q8IXW7_HUMAN PVGYNKDINESDEVE--------VYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATY Q547R0_MOUSE Q547R0_MOUSE PVGYNKDINESDEVE--------VYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATY FMR1_MOUSE FMR1_MOUSE PVGYNKDINESDEVE--------VYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATY FMR1_RAT FMR1_RAT PVGYNKDINESDEVE--------VYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATY Q6AXB7_MOUSE Q6AXB7_MOUSE PVGYNKDINESDEVE--------VYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATY Q8BPK8_MOUSE Q8BPK8_MOUSE PVGYNKDINESDEVE--------VYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATY Q8BPN5_MOUSE Q8BPN5_MOUSE PVGYNKDINESDEVE--------VYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATY Q8VD80_RAT Q8VD80_RAT PVGYNKDINESDEVE--------VYSRANEKEPCCWWLTKVRMIKGEFYVIEYAACDATY Q4T116_TETNG Q4T116_TETNG PADYHKDIAEGEEVEVSTRYDFPVYSRANEQEPCGWWLARVKMIKGEFYVIEYAACDATY Q6NY99_DANRE Q6NY99_DANRE PTDYHKDICEGDEVE--------VYSRANEQEPCGWWLARVRMMKGEFYVIEYAACDATY Q7ZV52_DANRE Q7ZV52_DANRE PTDYHKDICEGDEVE--------VYSRANEQEPCGWWLAGVRMMKGEFYVIEYAACDATY FXR2_MOUSE FXR2_MOUSE PADYNKEITEGDEVE--------VYSRANEQEPCGWCLARVRMMKGDFYVIEYAACDATY FXR2_HUMAN FXR2_HUMAN PADYNKEITEGDEVE--------VYSRANEQEPCGWWLARVRMMKGDFYVIEYAACDATY Q86V09_HUMAN Q86V09_HUMAN PADYNKEITEGDEVE--------VYSRANEQEPCGWWLARVRMMKGDFYVIEYAACDATY B1H2A6_RAT B1H2A6_RAT PADYNKEITEGDEVE--------VYSRANEQEPCGWWLARVRMMKGDFYVIEYAACDATY Q3TA75_MOUSE Q3TA75_MOUSE PADYNKEITEGDEVE--------VYSRANEQEPCGWWLARVRMMKGDFYVIEYAACDATY Q6P5B5_MOUSE Q6P5B5_MOUSE PADYNKEITEGDEVE--------VYSRANEQEPCGWWLARVRMMKGDFYVIEYAACDATY Q4T723_TETNG Q4T723_TETNG PSDEKKDIGEGDEVE--------IFSRSNDQEPYGWWMGKVRMMKGDFYVIEYAAWNASY Q4TCM9_TETNG Q4TCM9_TETNG PSDEKKDIGEGDEVE--------IFSRSNDQEPYGWWMGKVRMMKGDFYVIEYAAWNASY Q9PUN3_DANRE Q9PUN3_DANRE SADTKKEIGEGEEVE--------IFSRANEQEPCGWWLAKVRMMKGDFYVIEYAACDATY Q6NUW6_DANRE Q6NUW6_DANRE SADTKKEIGEGEEVE--------IFSRANEQEPCGWWLAKVRMMKGDFYVIEYAACDATY Q7SXA0_DANRE Q7SXA0_DANRE SADTKKEIGEGEEVE--------ISSRANEQEPCGWWLAKVRMMKGDFYVIEYAACDATY Q4TCP2_TETNG Q4TCP2_TETNG PSDEKKDIGEGDEVE--------IFSRSNDQEPYGWWMGKVRMMKGDFYVIEYAAWNASY FXR1B_XENLA FXR1B_XENLA LPDIKKEITEGDEVE--------VYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATY A3KMH8_XENLA A3KMH8_XENLA LPDIKKEITEGDEVE--------VYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATY FXR1A_XENLA FXR1A_XENLA LPDIKKEITEGDEVE--------VYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATY FXR1_XENTR FXR1_XENTR LPDIKKEITEGDEVE--------VYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATY Q0VFT5_XENTR Q0VFT5_XENTR LPDIKKEITEGDEVE--------VYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATY Q5F3S6_CHICK Q5F3S6_CHICK PPDIKKEIGEGDEVE--------VYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATY FXR1_CRIGR FXR1_CRIGR PPDIKKEISEGDEVE--------VYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATY FXR1_MOUSE FXR1_MOUSE PPDIKKEISEGDEVE--------VYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATY FXR1_BOVIN FXR1_BOVIN PPDIKKEISEGDEVE--------VYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATY B4DM78_HUMAN B4DM78_HUMAN ------------------------------------------MMKGEFYVIEYAACDATY B4DXZ6_HUMAN B4DXZ6_HUMAN PPDIKKEISEGDEVE--------VYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATY FXR1_HUMAN FXR1_HUMAN PPDIKKEISEGDEVE--------VYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATY Q4R9A3_MACFA Q4R9A3_MACFA PPDLKKEISEGDEVE--------VYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATY Q4R3K8_MACFA Q4R3K8_MACFA ------------------------------------------------------------ B4DGH9_HUMAN B4DGH9_HUMAN ------------------------------------------MMKGEFYVIEYAACDATY Q5R8Z2_PONAB Q5R8Z2_PONAB P-DIKKEISEGDEVE--------VYSRANDQEPCGWWLAKVRMMKGELYVIEYAACDATY A6QLG6_BOVIN A6QLG6_BOVIN PPDIKKEISEGDEVE--------VYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATY Q5R8Y7_PONAB Q5R8Y7_PONAB PPDIKKGISEGDEVE--------VYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATY B4DM21_HUMAN B4DM21_HUMAN -----------------------VYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATY FXR1_RAT FXR1_RAT PPDIKKEISEGDEVE--------VYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATY Q8C7U4_MOUSE Q8C7U4_MOUSE ------------------------------------------------------------ MATCH CONSENSUS ?????K?I?E?DEVE????????VYSRAN??EPC?WWLA?VRM?KG?FYVIEYAACDATY

Q0V9Q1_XENTR Q0V9Q1_XENTR TKNVTIKQLRLVNPNKPLGKNDFCKVTLDVPTDLQHVFAEEFLLEDFKKAIGAFSVRYDW Q4SFA2_TETNG Q4SFA2_TETNG NEIVTLERLRPVNPNKPMVKNTFIKIRVDVPEDLQLMCSNESAHKEYKKAIRAFSVTYDS Q4TFI5_TETNG Q4TFI5_TETNG ------------------------------------------------------------ Q7SYM7_DANRE Q7SYM7_DANRE NEIVTLERLRPVNPNKAATKNTFLKTRLDVPEDLRQMCAKDSAHKDFKKAIGAFNVTYDS Q9DF20_DANRE Q9DF20_DANRE NEIVTLERLRPVNPNKAATKNTFLKTRLDVPEDLRQMCAKDSAHKDFKKAIGAFNVTYDS FMR1_XENTR FMR1_XENTR NEIVTIERLRSVNPNKPATKNSFHKVKLDVPEDLRQMCAKDSAHKDFKKAVGAFSVSYDS FMR1B_XENLA FMR1B_XENLA NEIVTIDRLRSVNPNKSATKNSFHKVKLDVPEDLRQMCAKDSAHKDFKKAVGAFSVSYDS B7ZRL0_XENLA B7ZRL0_XENLA NEIVTIERLRSVNPNKPATKSSFHKVKLDVPEDLRQMCAKDSAHKDFKKAVGAFSVSYDS FMR1A_XENLA FMR1A_XENLA NEIVTIERLRSVNPNKPATKSSFHKVKLDVPEDLRQMCAKDSAHKDFKKAVGAFSVSYDS B6CVD8_TAEGU B6CVD8_TAEGU NEIVTIERLRSVNPNKPATKDTFHKIKLAVPEDLRQMCAKESAHKDFKKAVGAFSVTYDS Q0II33_BOVIN Q0II33_BOVIN NEIVTIERLRSVNPNKPATKETFHKIKLDVPEDLRQMCAKESAHKDFKKAVGAFSVTYDP Q59GC1_HUMAN Q59GC1_HUMAN NEIVTIERLRSVNPNKPATKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDP FMR1_PONAB FMR1_PONAB NEIVTIERLRSVNPNKPATKDTFHKIKLDVPEDLRQMCAKESAHKDFKKAVGAFSVTYDP FMR1_HUMAN FMR1_HUMAN NEIVTIERLRSVNPNKPATKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDP A8MQB8_HUMAN A8MQB8_HUMAN NEIVTIERLRSVNPNKPATKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDP A6NNH4_HUMAN A6NNH4_HUMAN NEIVTIERLRSVNPNKPATKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDP Q8IXW7_HUMAN Q8IXW7_HUMAN NEIVTIERLRSVNPNKPATKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDP Q547R0_MOUSE Q547R0_MOUSE NEIVTIERLRSVNPNKPATKDTFHKIKLEVPEDLRQMCAKESAHKDFKKAVGAFSVTYDP FMR1_MOUSE FMR1_MOUSE NEIVTIERLRSVNPNKPATKDTFHKIKLEVPEDLRQMCAKESAHKDFKKAVGAFSVTYDP FMR1_RAT FMR1_RAT NEIVTIERLRSVNPNKPATKDTFHKIKLEVPEDLRQMCAKESAHKDFKKAVGAFSVTYDP Q6AXB7_MOUSE Q6AXB7_MOUSE NEIVTIERLRSVNPNKPATKDTFHKIKLEVPEDLRQMCAKESAHKDFKKAVGAFSVTYDP Q8BPK8_MOUSE Q8BPK8_MOUSE NEIVTIERLRSVNPNKPATKDTFHKIKLEVPEDLRQMCAKESAHKDFKKAVGAFSVTYDP Q8BPN5_MOUSE Q8BPN5_MOUSE NEIVTIERLRSVNPNKPATKDTFHKIKLEVPEDLRQMCAKESAHKDFKKAVGAFSVTYDP Q8VD80_RAT Q8VD80_RAT NEIVTIERLRSVNPNKPATKDTFHKIKLEVPEDLRQMCAKESAHKDFKKAVGAFSVTYDP Q4T116_TETNG Q4T116_TETNG NEIVTAERIRPLNPNCPCSSNSFHKIQIPVPEDLRDICSNDNIHKDLRKAVGANSIFYNA Q6NY99_DANRE Q6NY99_DANRE NEIVTSERIRPVNPNSPSAQNSFYKVPIAVPEDLRDICLTENIHKDFRKAIGANCIFYNT Q7ZV52_DANRE Q7ZV52_DANRE NEIVTSERIRPVNPNSPSAQNSFYKVPIAVPEDLRDICLTENIHKDFRKAIGANCIFYNT FXR2_MOUSE FXR2_MOUSE NEIVTLERLRPVNSSSLATKGSFFKVTMAVPEDLREACSNENVHKEFKKALGANCIFLNI FXR2_HUMAN FXR2_HUMAN NEIVTLERLRPVNPNPLATKGSFFKVTMAVPEDLREACSNENVHKEFKKALGANCIFLNI Q86V09_HUMAN Q86V09_HUMAN NEIVTLERLRPVNPNPLATKGSFFKVTMAVPEDLREACSNENVHKEFKKALGANCIFLNI B1H2A6_RAT B1H2A6_RAT NEIVTLERLRPVNPNPLATKGSFFKVTMAVPEDLREACSNENVHKEFKKALGANCIFLNI Q3TA75_MOUSE Q3TA75_MOUSE NEIVTLERLRPVNPSPLATKGSFFKVTMAVPEDLREACSNENVHKEFKKALGANCIFLNI Q6P5B5_MOUSE Q6P5B5_MOUSE NEIVTLERLRPVNPSPLATKGSFFKVTMAVPEDLREACSNENVHKEFKKALGANCIFLNI Q4T723_TETNG Q4T723_TETNG NEIVTFERLRPVNPNKPITKDSFFKCTVPVPQDLQEACQNENAHKDFKKAVGAIHVSYSP Q4TCM9_TETNG Q4TCM9_TETNG NEIVTFERLRPVNPNKPITKDSFFKCTVPVPQDLQEACQNENAHKDFKKAVGAIHVSYSP Q9PUN3_DANRE Q9PUN3_DANRE NEIVTFERLRPVNRNKAVTESTFFRCSVPVPEDLRAACESEQAHKEFKKAVGAIRIVYSP Q6NUW6_DANRE Q6NUW6_DANRE NEIVTFERLRPVNRNKAVTESTFFRCSVPVPEDLRAACESEQAHKEFKKAVGAIRIVYSP Q7SXA0_DANRE Q7SXA0_DANRE NEIVTFERLRPVNRNKAVTESTFFRCSVPVPEDLRAACESEQAHKEFKKAVGAIRIVYSP Q4TCP2_TETNG Q4TCP2_TETNG NEIVTFERLRPVNPNKPITKDSFFKCTVPVPQDLQEACQNENAHKDFKKAVGAIHVSYSP FXR1B_XENLA FXR1B_XENLA NEIVTFERLRPVNQNKSVTKNSFFKCTVDVPEDLRESCSNENVHKEFKKAVGACRVYFHA A3KMH8_XENLA A3KMH8_XENLA NEIVTFERLRPVNQNKTVTKNSFFKCTVDVPEDLRESCSNENVHKEFKKAVGACRVYFHA FXR1A_XENLA FXR1A_XENLA NEIVTFERLRPVNQNKTVTKNSFFKCTVDVPEDLRESCSNENVHKEFKKAVGACRVYFHA FXR1_XENTR FXR1_XENTR NEIVTFERLRPGNQNKSVTKSSFFKCTVDVPEDLREPCSNENVHKEFKKAVGACRVYFHA Q0VFT5_XENTR Q0VFT5_XENTR NEIVTFERLRPGNQNKSVTKSSFFKCTVDVPEDLREPCSNENVHKEFKKAVGACRVYFHA Q5F3S6_CHICK Q5F3S6_CHICK NEIVTYERLRPVNQNKTVKKNTFFKCTVDVPEDLRDACANENAHKDFKKAVGACRIFYHA FXR1_CRIGR FXR1_CRIGR NEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHP FXR1_MOUSE FXR1_MOUSE NEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHP FXR1_BOVIN FXR1_BOVIN NEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKDYKKAVGACRIFYHP B4DM78_HUMAN B4DM78_HUMAN NEIVTFERLRPVNQNKTVKKNTFFKCTMDVPEDLREACANENAHKDFKKAVGACRIFYHP B4DXZ6_HUMAN B4DXZ6_HUMAN NEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHP FXR1_HUMAN FXR1_HUMAN NEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHP Q4R9A3_MACFA Q4R9A3_MACFA NEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHP Q4R3K8_MACFA Q4R3K8_MACFA ------------------------------------------------------------ B4DGH9_HUMAN B4DGH9_HUMAN NEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHP Q5R8Z2_PONAB Q5R8Z2_PONAB NEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHP A6QLG6_BOVIN A6QLG6_BOVIN NEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHP Q5R8Y7_PONAB Q5R8Y7_PONAB NEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHP B4DM21_HUMAN B4DM21_HUMAN NEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHP FXR1_RAT FXR1_RAT NEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHP Q8C7U4_MOUSE Q8C7U4_MOUSE ------------------------------------------------------------ MATCH CONSENSUS NEIVT?ERLR?VN?NK???K??F?K????VPEDLR??C??E??HK?FKKA?GA???????

Q0V9Q1_XENTR Q0V9Q1_XENTR VSSQIIIL--------------------SSNEFTGKWVNMLKDNLFHSLKLKQFLKVGKK Q4SFA2_TETNG Q4SFA2_TETNG KKHQLVIL--------------------SVNEVTRKRTNMINDMHFRSLRSKLFVIQGNQ Q4TFI5_TETNG Q4TFI5_TETNG ------------------------------------------------------------ Q7SYM7_DANRE Q7SYM7_DANRE EEKQLVIL--------------------SVNEVTAKRISMLSDMHFRSLRTKLALILRNE Q9DF20_DANRE Q9DF20_DANRE EEKQLVIL--------------------SVNEVTAKRISMLSDMHFRSLRTKLALILRNE FMR1_XENTR FMR1_XENTR ENYQLVIL--------------------SVNEVTIKRANMLSDMHFRSLRTKLSLMLRNE FMR1B_XENLA FMR1B_XENLA ENYQLVIL--------------------SVNEVTIKRANMLCDMHFRSLRTKLSLMLRNE B7ZRL0_XENLA B7ZRL0_XENLA ENYQLVIL--------------------SVNEVSIKRASMLSDMHFRSLRTKLSLMLRNE FMR1A_XENLA FMR1A_XENLA ENYQLVIL--------------------SVNEVSIKRASMLSDMHFRSLRTKLSLMLRNE B6CVD8_TAEGU B6CVD8_TAEGU ENHQLIIL--------------------SINDVTTKRANMLIDMHFRSLRTKLSLILRNE Q0II33_BOVIN Q0II33_BOVIN ENYQLVVL--------------------SISEVTSKRAHMLIDMHFRSLRTKLSLILRNE Q59GC1_HUMAN Q59GC1_HUMAN ENYQLVIL--------------------SINEVTSKRAHMLIDMHFRSLRTKLSLIMRNE FMR1_PONAB FMR1_PONAB ENYQLVIL--------------------SINEVTSKRAHMLIDMHFRSLRTKLSLIMRNE FMR1_HUMAN FMR1_HUMAN ENYQLVIL--------------------SINEVTSKRAHMLIDMHFRSLRTKLSLIMRNE A8MQB8_HUMAN A8MQB8_HUMAN ENYQLVIL--------------------SINEVTSKRAHMLIDMHFRSLRTKLSLIMRNE A6NNH4_HUMAN A6NNH4_HUMAN ENYQLVIL--------------------SINEVTSKRAHMLIDMHFRSLRTKLSLIMRNE Q8IXW7_HUMAN Q8IXW7_HUMAN ENYQLVIL--------------------SINEVTSKRAHMLIDMHFRSLRTKLSLIMRNE Q547R0_MOUSE Q547R0_MOUSE ENYQLVIL--------------------SINEVTSKRAHMLIDMHFRSLRTKLSLILRNE FMR1_MOUSE FMR1_MOUSE ENYQLVIL--------------------SINEVTSKRAHMLIDMHFRSLRTKLSLILRNE FMR1_RAT FMR1_RAT ENYQLVIL--------------------SINEVTSKRAHMLIDMHFRSLRTKLSLILRNE Q6AXB7_MOUSE Q6AXB7_MOUSE ENYQLVIL--------------------SINEVTSKRAHMLIDMHFRSLRTKLSLILRNE Q8BPK8_MOUSE Q8BPK8_MOUSE ENYQLVIL--------------------SINEVTSKRAHMLIDMHFRSLRTKLSLILRNE Q8BPN5_MOUSE Q8BPN5_MOUSE ENYQLVIL--------------------SINEVTSKRAHMLIDMHFRSLRTKLSLILRNE Q8VD80_RAT Q8VD80_RAT ENYQLVIL--------------------SIN----------------------------- Q4T116_TETNG Q4T116_TETNG QNHELIVL--------------------STNGATVKRATLLSDMHFRSIRTKLMLMSRNE Q6NY99_DANRE Q6NY99_DANRE STHQLIVL--------------------STNESTVKRAGLLSDMHFRSIRTKLMLMSRNE Q7ZV52_DANRE Q7ZV52_DANRE STHQLIVL--------------------STNESTVKRAGLLSDMHFRSIRTKLMLMSRNE FXR2_MOUSE FXR2_MOUSE TNSELFIL--------------------STTEAPVKRASLLGDMHFRSLRTKLLLMSRNE FXR2_HUMAN FXR2_HUMAN TNSELFIL--------------------STTEAPVKRASLLGDMHFRSLRTKLLLMSRNE Q86V09_HUMAN Q86V09_HUMAN TNSELFIL--------------------STTEAPVKRASLLGDMHFRSLRTKLLLMSRNE B1H2A6_RAT B1H2A6_RAT TDSELFIL--------------------STTEAPVKRASLLGDMHFRSLRTKLLLMSRNE Q3TA75_MOUSE Q3TA75_MOUSE TNSELFIL--------------------STTEAPVKRASLLGDMHFRSLRTKLLLMSRNE Q6P5B5_MOUSE Q6P5B5_MOUSE TNSELFIL--------------------STTEAPVKRASLLGDMHFRSLRTKLLLMSRNE Q4T723_TETNG Q4T723_TETNG ESSELVIV--------------------STSETTVKRVSLLSDMHLRNLRTKLLLMSRNH Q4TCM9_TETNG Q4TCM9_TETNG ESSELVIVVTLPPKSSPGCVVSAGTPASSTSETTVKRVSLLSDMHLRNLRTKLLLMSRNH Q9PUN3_DANRE Q9PUN3_DANRE EKSELVVL--------------------SLSEATVKRVSLLSDIHLRSIRTKLMLMSRNQ Q6NUW6_DANRE Q6NUW6_DANRE EKSELVVL--------------------SLSEATVKRVSLLSDIHLRSIRTKLMLMSRNQ Q7SXA0_DANRE Q7SXA0_DANRE EKSELVVL--------------------SLSEATVKRVSLLSDIHLRSIRTKLMLMSRNQ Q4TCP2_TETNG Q4TCP2_TETNG ESSELVIV------------------------VTLPPKSSPDHGEARVFAQRHAPAQPQD FXR1B_XENLA FXR1B_XENLA ETNQLIIL--------------------SASESTVKRVNILSDMHLRSIRTKLMLMSRNE A3KMH8_XENLA A3KMH8_XENLA ETNQLIIL--------------------SACESTVKRVNILSDMHLRSIRTKLMLMSRNE FXR1A_XENLA FXR1A_XENLA ETNQLIIL--------------------SACESTVKRVNILSDMHLRSIRTKLMLMSRNE FXR1_XENTR FXR1_XENTR ETNQLIIL--------------------SACESTVKRVTILSDMHLRSIRTKLMLMSRNE Q0VFT5_XENTR Q0VFT5_XENTR ETNQLIIL--------------------SACESTVKRVTILSDMHLRSIRTKLMLMSRNE Q5F3S6_CHICK Q5F3S6_CHICK ETAQLIIL--------------------SASEATVKRVNILSDMHLRSIRTKLMLMSRNE FXR1_CRIGR FXR1_CRIGR ETTQLMIL--------------------SASEATVKRVNILSDMHLRSIRTKLMLMSRNE FXR1_MOUSE FXR1_MOUSE ETTQLMIL--------------------SASEATVKRVNILSDMHLRSIRTKLMLMSRNE FXR1_BOVIN FXR1_BOVIN ETTQLMIL--------------------SASEATVKRVNILSDMHLRSIRTKLMLMSRNE B4DM78_HUMAN B4DM78_HUMAN ETTQLMIL--------------------SASEATVKRVNILSDMHLRSIRTKLMLMSRNE B4DXZ6_HUMAN B4DXZ6_HUMAN ETTQLMIL--------------------SASEATVKRVNILSDMHLRSIRTKLMLMSRNE FXR1_HUMAN FXR1_HUMAN ETTQLMIL--------------------SASEATVKRVNILSDMHLRSIRTKLMLMSRNE Q4R9A3_MACFA Q4R9A3_MACFA ETTQLMIL--------------------SASEATVKRVNILSDMHLRSIRTKLMLMSRNE Q4R3K8_MACFA Q4R3K8_MACFA ------------------------------------------------------------ B4DGH9_HUMAN B4DGH9_HUMAN ETTQLMIL--------------------SASEATVKRVNILSDMHLRSIRTKLMLMSGNE Q5R8Z2_PONAB Q5R8Z2_PONAB ETTQLMIL--------------------SASEATVKRVNILSDMHLRSIRTKLMLMSRNE A6QLG6_BOVIN A6QLG6_BOVIN ETTQLMIL--------------------SASEATVKRVNILSDMHLRSIRTKLMLMSRNE Q5R8Y7_PONAB Q5R8Y7_PONAB ETTQLMIL--------------------SASEATVKRVNILSDMHLRSIRTKLMLMSRNE B4DM21_HUMAN B4DM21_HUMAN ETTQLMIL--------------------SASEATVKRVNILSDMHLRSIRTKLMLMSRNE FXR1_RAT FXR1_RAT ETTQLMIL--------------------SASEATVKRVNILSDMHLRSIRTKLMLMSRNE Q8C7U4_MOUSE Q8C7U4_MOUSE ------------------------------------------------------------ MATCH CONSENSUS ????L?IL????????????????????S??E?T?KR???L?DMH?RS?RTKL?L??RNE

Q0V9Q1_XENTR Q0V9Q1_XENTR KAREKLE-----KFLAKYHDQVMVKQRLIGLAIGKKGSNIQKAKKIP-------GIIAID Q4SFA2_TETNG Q4SFA2_TETNG EAIRHLEKSR--QMAARFHEQFTVREDLMGLAIGTHGTNIQQARKVP-------GVTNID Q4TFI5_TETNG Q4TFI5_TETNG ------------------------------------------------------------ Q7SYM7_DANRE Q7SYM7_DANRE EATRQLESSR--QLASRFHEQFVVRDDLMGLAIGTHGANIQQARKIS-------GVTTID Q9DF20_DANRE Q9DF20_DANRE EATRQLESSR--QLASRFHEQFVERDDLMGLAIGTHGANIQQARKIS-------GVTTID FMR1_XENTR FMR1_XENTR EASKQLESSR--QLASRFHEQFIVREDLMGLAIGTHGANIQQARKVP-------GVTAID FMR1B_XENLA FMR1B_XENLA EASKQLESSR--QLASRFHEQFIVREDLMGLAIGTHGANIQQARKVP-------GVTAID B7ZRL0_XENLA B7ZRL0_XENLA EASKQLESSR--QLASRFHEQFIVREDLMGLAIGTHGANIQQARKVP-------GVTAID FMR1A_XENLA FMR1A_XENLA EASKQLESSR--QLASRFHEQFIVREDLMGLAIGTHGANIQQARKVP-------GVTAID B6CVD8_TAEGU B6CVD8_TAEGU EASKQLESSR--QLASRFHEQFVVREDLMGLAIGTHGANIQQARKVP-------GVTAID Q0II33_BOVIN Q0II33_BOVIN EASKQLESSR--QLASRFHEQFVVREDLMGLAIGTHGANIQQARKVP-------GVTAID Q59GC1_HUMAN Q59GC1_HUMAN EASKQLESSR--QLASRFHEQFIVREDLMGLAIGTHGANIQQARKVP-------GVTAID FMR1_PONAB FMR1_PONAB EASKQLESSR--QLASRFHEQFIVREDLMGLAIGTHGANIQQARKVP-------GVTAID FMR1_HUMAN FMR1_HUMAN EASKQLESSR--QLASRFHEQFIVREDLMGLAIGTHGANIQQARKVP-------GVTAID A8MQB8_HUMAN A8MQB8_HUMAN EASKQLESSR--QLASRFHEQFIVREDLMGLAIGTHGANIQQARKVP-------GVTAID A6NNH4_HUMAN A6NNH4_HUMAN EASKQLESSR--QLASRFHEQFIVREDLMGLAIGTHGANIQQARKVP-------GVTAID Q8IXW7_HUMAN Q8IXW7_HUMAN EASKQLESSR--QLASRFHEQFIVREDLMGLAIGTHGANIQQARKVP-------GVTAID Q547R0_MOUSE Q547R0_MOUSE EASKQLESSR--QLASRFHEQFIVREDLMGLAIGTHGANIQQARKVP-------GVTAID FMR1_MOUSE FMR1_MOUSE EASKQLESSR--QLASRFHEQFIVREDLMGLAIGTHGANIQQARKVP-------GVTAID FMR1_RAT FMR1_RAT EASKQLESSR--QLASRFHEQFIVREDLMGLAIGTHGANIQQARKVP-------GVTAID Q6AXB7_MOUSE Q6AXB7_MOUSE EASKQLESSR--QLASRFHEQFIVREDLMGLAIGTHGANIQQARKVP-------GVTAID Q8BPK8_MOUSE Q8BPK8_MOUSE EASKQLESSR--QLASRFHEQFIVREDLMGLAIGTHGANIQQARKVP-------GVTAID Q8BPN5_MOUSE Q8BPN5_MOUSE EASKQLESSR--QLASRFHEQFIVREDLMGLAIGTHGANIQQARKVP-------GVTAID Q8VD80_RAT Q8VD80_RAT ------------------------------------------------------------ Q4T116_TETNG Q4T116_TETNG EASKHLETSK--QLASAYQEEVKVSEDLMGLAIGSHGANIQQARKVP-------GVTAIE Q6NY99_DANRE Q6NY99_DANRE EATKHLETSK--QLASAYQEEVKVREDLMGLAIGSHGANIQQARKVP-------GVTAIE Q7ZV52_DANRE Q7ZV52_DANRE EATKHLETSK--QLASAYQEEVKVREDLMGLAIGSHGANIQQARKVP-------GVTAIE FXR2_MOUSE FXR2_MOUSE EATKHLETSK--QLAAAFQEEFTVREDLMGLAIGTHGANIQQARKVP-------GVTAIE FXR2_HUMAN FXR2_HUMAN EATKHLETSK--QLAAAFQEEFTVREDLMGLAIGTHGANIQQARKVP-------GVTAIE Q86V09_HUMAN Q86V09_HUMAN EATKHLETSK--QLAAAFQEEFTVREDLMGLAIGTHGANIHQARKVP-------GVTAIE B1H2A6_RAT B1H2A6_RAT EATKHLETSK--QLAAAFQEEFTVREDLMGLAIGTHGANIQQARKVP-------GVTAIE Q3TA75_MOUSE Q3TA75_MOUSE EATKHLETSK--QLAAAFQEEFTVREDLMGLAIGTHGANIQQARKVP-------GVTAIE Q6P5B5_MOUSE Q6P5B5_MOUSE EATKHLETSK--QLAAAFQEEFTVREDLMGLAIGTHGANIQQARKVP-------GVTAIE Q4T723_TETNG Q4T723_TETNG EATKHLESSR--QLVSSFQEEFAVRPDLMGLAIGSHGSNIQQARKVA-------GVTAIE Q4TCM9_TETNG Q4TCM9_TETNG EATKHLESSR--QLVSSFQEEFAVRPDLMGLAIGSHGSNIQQARKE-------------- Q9PUN3_DANRE Q9PUN3_DANRE EATKHLESTK--QLASAFQEEFTVREDLMGLAIGSHGSNIQQARKVP-------GVTAIE Q6NUW6_DANRE Q6NUW6_DANRE EATKHLESTK--QLASAFQEEFTVREDLMGLAIGSHGSNIQQARKVP-------GVTAIE Q7SXA0_DANRE Q7SXA0_DANRE EATKHLESTK--QLASAFQEEFTVREDLMGLAIGSHGSNIQQARKVP-------GVTAIE Q4TCP2_TETNG Q4TCP2_TETNG QAAADVAQPRGNQASGELQAAGVVFPGRVCGEAGPDGPGHRQPRQQHPAGSQGGGVTAIE FXR1B_XENLA FXR1B_XENLA EATKHLECTK--QLASAFHEEFDVREDLMGLAIGTHGSNIQQARKVP-------GITAIE A3KMH8_XENLA A3KMH8_XENLA EATKHLECTK--QLASAFHEEFIVREDLMGLAIGTHGSNIQQARKVP-------GITAIE FXR1A_XENLA FXR1A_XENLA EATKHLECTK--QLASAFHEEFIVREDLMGLAIGTHGSNIQQARKVP-------GITAIE FXR1_XENTR FXR1_XENTR EATKHLECTK--QLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVP-------GITAIE Q0VFT5_XENTR Q0VFT5_XENTR EATKHLECTK--QLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVP-------GITAIE Q5F3S6_CHICK Q5F3S6_CHICK EATKHLECTK--QLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVP-------GVTAIE FXR1_CRIGR FXR1_CRIGR EATKHLECTK--QLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVP-------GVTAIE FXR1_MOUSE FXR1_MOUSE EATKHLECTK--QLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVP-------GVTAIE FXR1_BOVIN FXR1_BOVIN EATKHLECTK--QLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVP-------GVTAIE B4DM78_HUMAN B4DM78_HUMAN EATKHLECTK--QLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVP-------GVTAIE B4DXZ6_HUMAN B4DXZ6_HUMAN EATKHLECTK--QLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVP-------GVTAIE FXR1_HUMAN FXR1_HUMAN EATKHLECTK--QLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVP-------GVTAIE Q4R9A3_MACFA Q4R9A3_MACFA EATKHLECTK--QLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVP-------GVTAIE Q4R3K8_MACFA Q4R3K8_MACFA ------------------------------------------------------------ B4DGH9_HUMAN B4DGH9_HUMAN EATKHLECTK--QLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVP-------GVTAIE Q5R8Z2_PONAB Q5R8Z2_PONAB EATKHLECTK--QLAAAFHEEFDVREDLMGLAIGTHGSNIQQARKVP-------GVTAIE A6QLG6_BOVIN A6QLG6_BOVIN EATKHLECTK--QLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVP-------GVTAIE Q5R8Y7_PONAB Q5R8Y7_PONAB EATKHLECTK--QLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVP-------GVTAIE B4DM21_HUMAN B4DM21_HUMAN EATKHLECTK--QLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVP-------GVTAIE FXR1_RAT FXR1_RAT EATKHLECTK--QLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVP-------GVTAIE Q8C7U4_MOUSE Q8C7U4_MOUSE ------------------------------------------------------------ MATCH CONSENSUS EA?K?LE?????QLA??F?E?F?VREDLMGLAIG?HG?NIQQARKVP???????GVTAI?

Q0V9Q1_XENTR Q0V9Q1_XENTR FDQENRTFHIYGNSRESVSKAKAYMEFKEKELQVSQIL----VGKAFSKNRNFIRQIAKK Q4SFA2_TETNG Q4SFA2_TETNG LDEETCTFHIYGESQEAVRMARSVLEFTEDVIDVPRNLRFVFLGKVIGRNGKLIQEVVNK Q4TFI5_TETNG Q4TFI5_TETNG ------------QSQEAVRMARSVLEFTEDVIDVPRNLRFVFLGKVIGRNGKLIQEVVNK Q7SYM7_DANRE Q7SYM7_DANRE LDEETCTFHIYGEDQEAVRKARSYLEFSEDVIKVPRNL----VGKVIGKSGKLIQEVVDK Q9DF20_DANRE Q9DF20_DANRE LDEETCTFHIYGEDQEAVRKARSYLEFSEDVIKVPRNL----VGKVIGKSGKLIQEVVDK FMR1_XENTR FMR1_XENTR LDEDTCTFHIYGEDQEAVKKARTYLEFAEDVIQVPRNL----VGKVIGKNGKLIQEIVDK FMR1B_XENLA FMR1B_XENLA LDEDTCTFHIYGEDQEAVKKARTYLEFAEDVIQVPRNL----VGKVIGKNGKLIQEIVDK B7ZRL0_XENLA B7ZRL0_XENLA LDEDTCTFHIYGEDQEAVKKARTYLEFAEDVIQVPRNL----VGKVIGKNGKLIQEIVDK FMR1A_XENLA FMR1A_XENLA LDEDTCTFHIYGEDQEAVKKARTYLEFAENVIQVPRNL----VGKVIGKNGKLIQEIVDK B6CVD8_TAEGU B6CVD8_TAEGU LDEDTCTFHIYGEDQDAVKKARSYLEFAEDVIQVPRNL----VGKVIGKNGKLIQEIVDK Q0II33_BOVIN Q0II33_BOVIN LDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNL----VGKVIGKKKKK------- Q59GC1_HUMAN Q59GC1_HUMAN LDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNL----VGKVIGKNGKLIQEIVDK FMR1_PONAB FMR1_PONAB LDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNL----VGKVIGKNGKLIQEIVDK FMR1_HUMAN FMR1_HUMAN LDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNL----VGKVIGKNGKLIQEIVDK A8MQB8_HUMAN A8MQB8_HUMAN LDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNL----VGKVIGKNGKLIQEIVDK A6NNH4_HUMAN A6NNH4_HUMAN LDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNL----VGKVIGKNGKLIQEIVDK Q8IXW7_HUMAN Q8IXW7_HUMAN LDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNL----VGLKI------------- Q547R0_MOUSE Q547R0_MOUSE LDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNL----VGKVIGKNGKLIQEIVDK FMR1_MOUSE FMR1_MOUSE LDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNL----VGKVIGKNGKLIQEIVDK FMR1_RAT FMR1_RAT LDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNL----VGKVIGKNGKLIQEIVDK Q6AXB7_MOUSE Q6AXB7_MOUSE LDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNL----VGKVIGKNGKLIQEIVDK Q8BPK8_MOUSE Q8BPK8_MOUSE LDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNL----VGKVIGKNGKLIQEIVDK Q8BPN5_MOUSE Q8BPN5_MOUSE LDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNL----VGKVIG------------ Q8VD80_RAT Q8VD80_RAT ------------------------------------------------------------ Q4T116_TETNG Q4T116_TETNG LEEESCTFRIYGETPEAVRQAREYLEFREEYFQVPRNL----VGKVIGKSGKVIQEIVDK Q6NY99_DANRE Q6NY99_DANRE LEEESCTFRIYGETPEAVKQARTYLEFKEDSFPVPRNL----VGKVIGKNGKIIQEIVDK Q7ZV52_DANRE Q7ZV52_DANRE LEEESCTFRIYGETPEAVKQARTYLEFKEDSFPVPRNL----VGKVIGKNGKIIQEIVDK FXR2_MOUSE FXR2_MOUSE LGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRDL----VGKVTGKTGKVIQGIVDK FXR2_HUMAN FXR2_HUMAN LGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRNL----VGKVIGKNGKVIQEIVDK Q86V09_HUMAN Q86V09_HUMAN LGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRNL----VGKVIGKNGKVIQEIVDK B1H2A6_RAT B1H2A6_RAT LGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRNL----VGKVIGKNGKVIQEIVDK Q3TA75_MOUSE Q3TA75_MOUSE LGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRNL----VGNVIGKNGKVIQEIVDK Q6P5B5_MOUSE Q6P5B5_MOUSE LGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRNL----VGKVIGKNGKVIQEIVDK Q4T723_TETNG Q4T723_TETNG LNEETGTFKIYGQTAEAVKKARSFLEFVEDSVQVPRNL----VGKVIGKNGKVIQEIVDK Q4TCM9_TETNG Q4TCM9_TETNG -----------GASP-------AHPPFSSSSPP---------EGKVIGKNGKVIQEIVDK Q9PUN3_DANRE Q9PUN3_DANRE LEEETGTFRIYGESTETLQKARNYLEFLEDSVQIPRNL----VGKVIGKSGKVIQEIVDK Q6NUW6_DANRE Q6NUW6_DANRE LEEETGTFRIYGESTEAVQKARNYLEFLEDSVQIPRNL----VGKVIGKNGKVIQEIVDK Q7SXA0_DANRE Q7SXA0_DANRE LEEETGTFRIYGESTEAVQKARNYLEFLEDSVQIPRNL----VGKVIGKNGKVIQEIVDK Q4TCP2_TETNG Q4TCP2_TETNG LNEETGTFKIYGQEGAS----PAHPPFSSSSPP---------EGKVIGKNGKVIQEIVDK FXR1B_XENLA FXR1B_XENLA LDEDSGTFRIYGESEEAVKKARSYLEFVEDFIQVPRNL----VGKVIGKNGKVIQEIVDK A3KMH8_XENLA A3KMH8_XENLA LDEDSGTFRIYGESAEAVKKARSYLEFVEDFIQVPRNL----VGKVIGKNGKVIQEIVDK FXR1A_XENLA FXR1A_XENLA LDEDSGTFRIYGESAEAVKKARSYLEFVEDFIQVPRNL----VGKVIGKNGKVIQEIVDK FXR1_XENTR FXR1_XENTR LDEDSGTFRIYGESAEAVKKARSYLEFVEDFIQVPRNL----VGKVIGKNGKVIQEIVDK Q0VFT5_XENTR Q0VFT5_XENTR LDEDSGTFRIYGESAEAVKKARSYLEFVEDFIQVPRNL----VGKVIGKNGKVIQEIVDK Q5F3S6_CHICK Q5F3S6_CHICK LEEDTGTFRIYGETADAVKKARSYLEFVEDFIQVPRNL----VGKVIGKNGKVIQEIVDK FXR1_CRIGR FXR1_CRIGR LDEDTGTFRIYGESAEAVKKARGFMEFVEDFIQVPRNL----VGKVIGKNGKVIQEIVDK FXR1_MOUSE FXR1_MOUSE LDEDTGTFRIYGESAEAVKKARGFLEFVEDFIQVPRNL----VGKVIGKNGKVIQEIVDK FXR1_BOVIN FXR1_BOVIN LDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNL----VGKVIGKNGKVIQEIVDK B4DM78_HUMAN B4DM78_HUMAN LDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNL----VGKVIGKNGKVIQEIVDK B4DXZ6_HUMAN B4DXZ6_HUMAN LDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNL----VGKVIGKNGKVIQEIVDK FXR1_HUMAN FXR1_HUMAN LDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNL----VGKVIGKNGKVIQEIVDK Q4R9A3_MACFA Q4R9A3_MACFA LDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNL----VGKVIGKNGKVIQEIVNK Q4R3K8_MACFA Q4R3K8_MACFA ------------------------------------------------------------ B4DGH9_HUMAN B4DGH9_HUMAN LDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNL----VGKVIGKNGKVIQEIVDK Q5R8Z2_PONAB Q5R8Z2_PONAB LDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNL----VGKVIGKNGKVIQEIVDK A6QLG6_BOVIN A6QLG6_BOVIN LDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNL----VGKVIGKNGKVIQEIVDK Q5R8Y7_PONAB Q5R8Y7_PONAB LDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNL----VGKVIGKNGKVIQEIVDK B4DM21_HUMAN B4DM21_HUMAN LDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNL----VGKVIGKNGKVIQEIVDK FXR1_RAT FXR1_RAT LDEDTGTFRIYGESAEAVKKARGFLEFVEDFIQVPRNL----VGKVIGKNGKVIQEIVDK Q8C7U4_MOUSE Q8C7U4_MOUSE --------------------------------------------------------IVDK MATCH CONSENSUS L?E???TF?IYGE???AV??AR??LEF?ED??QVPRNL????VGKVIGKNGK?IQEIVDK

Q0V9Q1_XENTR Q0V9Q1_XENTR SGVVYIRTE--DEEYL-STEG--------------------------------------- Q4SFA2_TETNG Q4SFA2_TETNG SGVVRVCIEPENDANP-PAVAADKVGGRERAEQRPLWSTQPICVRPIHCWVYFLSLLQ-- Q4TFI5_TETNG Q4TFI5_TETNG SGVVRVCIEPENDANP-PAVAADKVGGRERAQQRPYGRRSPSAAATSCFAIHSSSSSSSS Q7SYM7_DANRE Q7SYM7_DANRE SGVVRVRVEPENDKKPSPLEE--------------------------------------- Q9DF20_DANRE Q9DF20_DANRE SGVVRVRVEPENDKKPSPLEE--------------------------------------- FMR1_XENTR FMR1_XENTR SGVVRVRIEAENDKNI-SPEE--------------------------------------- FMR1B_XENLA FMR1B_XENLA SGVVRVRIEAENDKNI-SQEE--------------------------------------- B7ZRL0_XENLA B7ZRL0_XENLA SGVVRVRIEAENDKNI-SQEE--------------------------------------- FMR1A_XENLA FMR1A_XENLA SGVVRVRIEAENDKNI-SQEE--------------------------------------- B6CVD8_TAEGU B6CVD8_TAEGU SGVVRVRIEAENDKNI-PQEE--------------------------------------- Q0II33_BOVIN Q0II33_BOVIN ------------------------------------------------------------ Q59GC1_HUMAN Q59GC1_HUMAN SGVVRVRIEAENEKNV-PQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKENSTHFSQPN FMR1_PONAB FMR1_PONAB SGVVRVRIEAENEKNV-PQEEEIMPPNSLPSNNSRVGPNAPEEKKHLEIKENSTHFSQPN FMR1_HUMAN FMR1_HUMAN SGVVRVRIEAENEKNV-PQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKENSTHFSQPN A8MQB8_HUMAN A8MQB8_HUMAN SGVVRVRIEAENEKNV-PQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKENSTHFSQPN A6NNH4_HUMAN A6NNH4_HUMAN SGVVRVRIEAENEKNV-PQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKENSTHFSQPN Q8IXW7_HUMAN Q8IXW7_HUMAN ------------------------------------------------------------ Q547R0_MOUSE Q547R0_MOUSE SGVVRVRIEAENEKSV-PQEEEIMPPSSLPSNNSRVGPNSSEEKKHLDTKEN-THFSQPN FMR1_MOUSE FMR1_MOUSE SGVVRVRIEAENEKSV-PQEEEIMPPSSLPSNNSRVGPNSSEEKKHLDTKEN-THFSQPN FMR1_RAT FMR1_RAT SGVVRVRIEAENEKSV-PQEEENLPPSSLPSNNSRVGSNSSEEKKHLDTKENTHFSQPNS Q6AXB7_MOUSE Q6AXB7_MOUSE SGVVRVRIEAENEKSV-PQEEEIMPPSSLPSNNSRVGPNSSEEKKHLDTKEN-THFSQPN Q8BPK8_MOUSE Q8BPK8_MOUSE SGVVRVRIEAENEKSV-PQEE--------------------------------------- Q8BPN5_MOUSE Q8BPN5_MOUSE ------------------------------------------------------------ Q8VD80_RAT Q8VD80_RAT ------------------------------------------------------------ Q4T116_TETNG Q4T116_TETNG SGVVRVRIEGDNDKKL-PRVEVGRQGAGGDDTASSKE----------------------- Q6NY99_DANRE Q6NY99_DANRE SGVVRVRIEGDNDKKL-PREEGGRQGAGRDNIVSSQE----------------------- Q7ZV52_DANRE Q7ZV52_DANRE SGVVRVRIEGDNDKKL-PREEGGRQGAGRDNIVSSQE----------------------- FXR2_MOUSE FXR2_MOUSE SGVVRVRVEGDNDKKN-PKEG--------------------------------------- FXR2_HUMAN FXR2_HUMAN SGVVRVRVEGDNDKKN-PREE--------------------------------------- Q86V09_HUMAN Q86V09_HUMAN SGVVRVRVEGDNDKKN-PREE--------------------------------------- B1H2A6_RAT B1H2A6_RAT SGVVRVRVEGDNDKKN-PREE--------------------------------------- Q3TA75_MOUSE Q3TA75_MOUSE SGVVRVRVEGDNDKKN-PREE--------------------------------------- Q6P5B5_MOUSE Q6P5B5_MOUSE SGVVRVRVEGDNDKKN-PREE--------------------------------------- Q4T723_TETNG Q4T723_TETNG SGVVRVRIEGDNDTKQ-PRQEVSVLKAPLSRRWRSRGLQSAITTRLAPCDLLTQ------ Q4TCM9_TETNG Q4TCM9_TETNG SGVVRVRIEGDNDTKQ-PRQE--------------------------------------- Q9PUN3_DANRE Q9PUN3_DANRE SGVVRVRIEGDNDNKL-PRQE--------------------------------------- Q6NUW6_DANRE Q6NUW6_DANRE SGVVRVRIEGDNDNKL-PRQE--------------------------------------- Q7SXA0_DANRE Q7SXA0_DANRE SGVVRVRIEGDNDNKL-PRQE--------------------------------------- Q4TCP2_TETNG Q4TCP2_TETNG SGVVRVRIEGDNDTKQ-PRQEVSVLKAPLSRRWRSRGLQSAITTRLAPCDLLTQ------ FXR1B_XENLA FXR1B_XENLA SGVVRVRIEGDNETKL-PRED--------------------------------------- A3KMH8_XENLA A3KMH8_XENLA SGVVRVRIEGDNETKL-PRED--------------------------------------- FXR1A_XENLA FXR1A_XENLA SGVVRVRIEGDNETKL-PRED--------------------------------------- FXR1_XENTR FXR1_XENTR SGVVRVRIEGDNETKL-PRED--------------------------------------- Q0VFT5_XENTR Q0VFT5_XENTR SGVVRVRIEGDNETKL-PRED--------------------------------------- Q5F3S6_CHICK Q5F3S6_CHICK SGVVRVRIEGDNENKL-PRED--------------------------------------- FXR1_CRIGR FXR1_CRIGR SGVVRVRIEGDNENKL-PRED--------------------------------------- FXR1_MOUSE FXR1_MOUSE SGVVRVRIEGDNENKL-PRED--------------------------------------- FXR1_BOVIN FXR1_BOVIN SGVVRVRIEGDNENKL-PRED--------------------------------------- B4DM78_HUMAN B4DM78_HUMAN SGVVRVRIEGDNENKL-PRED--------------------------------------- B4DXZ6_HUMAN B4DXZ6_HUMAN SGVVRVRIEGDNENKL-PRED--------------------------------------- FXR1_HUMAN FXR1_HUMAN SGVVRVRIEGDNENKL-PRED--------------------------------------- Q4R9A3_MACFA Q4R9A3_MACFA SGVVRVRIEGDNENKL-PRED--------------------------------------- Q4R3K8_MACFA Q4R3K8_MACFA ------------------------------------------------------------ B4DGH9_HUMAN B4DGH9_HUMAN SGVVRVRIEGDNENKL-PRED--------------------------------------- Q5R8Z2_PONAB Q5R8Z2_PONAB SGVVRVRIEGDNENKL-PRED--------------------------------------- A6QLG6_BOVIN A6QLG6_BOVIN SGVVRVRIEGDNENKL-PRED--------------------------------------- Q5R8Y7_PONAB Q5R8Y7_PONAB SGVVRVRIEGDNENKL-PRED--------------------------------------- B4DM21_HUMAN B4DM21_HUMAN SGVVRVRIEGDNENKL-PRED--------------------------------------- FXR1_RAT FXR1_RAT SGVVRVRIEGDNENKL-PRED--------------------------------------- Q8C7U4_MOUSE Q8C7U4_MOUSE SGVVRVRIEGDNENKL-PRED--------------------------------------- MATCH CONSENSUS SGVVRVR?E??N?????P??????????????????????????????????????????

Q0V9Q1_XENTR Q0V9Q1_XENTR ---------------------------------HLVNFIIVGRRDNVVAAYVLLECHLNN Q4SFA2_TETNG Q4SFA2_TETNG ---------------------------------GLVPFVFLGTKESISNAKVLLDYHLNY Q4TFI5_TETNG Q4TFI5_TETNG SSSSSSSSSSSSSSSFTINEMIHCWVYFLSLLQGLVPFVFLGTKESISNAKVLLDYHLNY Q7SYM7_DANRE Q7SYM7_DANRE ---------------------------------GMVPFVFVGTKESISNARILLDYHLNY Q9DF20_DANRE Q9DF20_DANRE ---------------------------------GMVPFVFVGTKESISNARILLDYHLNY FMR1_XENTR FMR1_XENTR ---------------------------------GMVPFVFVGTKDSITNATVLLDYHLNY FMR1B_XENLA FMR1B_XENLA ---------------------------------GNVPFVFVGTKDSITNATVLLDYHLNY B7ZRL0_XENLA B7ZRL0_XENLA ---------------------------------GIVPFVFVGTKDSITNATVLLDYHLNY FMR1A_XENLA FMR1A_XENLA ---------------------------------GIVPFVFVGTKDSITNATVLLDYHLNY B6CVD8_TAEGU B6CVD8_TAEGU ---------------------------------GMVPFVFVGTKDSITNATVLLDYHLNY Q0II33_BOVIN Q0II33_BOVIN ------------------------------------------------------------ Q59GC1_HUMAN Q59GC1_HUMAN STKVQR---------------------------GMVPFVFVGTKDSIANATVLLDYHLNY FMR1_PONAB FMR1_PONAB STKVQR---------------------------GMVPFVFVGTKDSIANATVLLDYHLNY FMR1_HUMAN FMR1_HUMAN STKVQRVLVASSVVAGESQKPELKAWQ------GMVPFVFVGTKDSIANATVLLDYHLNY A8MQB8_HUMAN A8MQB8_HUMAN STKVQR---------------------------GMVPFVFVGTKDSIANATVLLDYHLNY A6NNH4_HUMAN A6NNH4_HUMAN STKVQRVLVASSVVAGESQKPELKAWQ------GMVPFVFVGTKDSIANATVLLDYHLNY Q8IXW7_HUMAN Q8IXW7_HUMAN ------------------------------------------------------------ Q547R0_MOUSE Q547R0_MOUSE STKVQRVLVVSSIVAGGPQKPEPKAWQ------GMVPFVFVGTKDSIANATVLLDYHLNY FMR1_MOUSE FMR1_MOUSE STKVQRVLVVSSIVAGGPQKPEPKAWQ------GMVPFVFVGTKDSIANATVLLDYHLNY FMR1_RAT FMR1_RAT TKVQR----------------------------GMVPFVFVGTKDSIANATVLLDYHLNY Q6AXB7_MOUSE Q6AXB7_MOUSE STKVQRVLVVSSIVAGGPQKPEPKAWQ------GMVPFVFVGTKDSIANATVLLDYHLNY Q8BPK8_MOUSE Q8BPK8_MOUSE ------------------------------------------------------------ Q8BPN5_MOUSE Q8BPN5_MOUSE ------------------------------------------------------------ Q8VD80_RAT Q8VD80_RAT ------------------------------------------------------------ Q4T116_TETNG Q4T116_TETNG ---------------------------------GMVPFVFVGTKENIKTAWALLEYHMSY Q6NY99_DANRE Q6NY99_DANRE ---------------------------------GTVPFIFVGTKENISNAQALLEYHVAY Q7ZV52_DANRE Q7ZV52_DANRE ---------------------------------GTVPFIFVGTKENISNAQALLEYHVAY FXR2_MOUSE FXR2_MOUSE ---------------------------------GMVPFIFVGTRENISNAQALLEYHLSY FXR2_HUMAN FXR2_HUMAN ---------------------------------GMVPFIFVGTRENISNAQALLEYHLSY Q86V09_HUMAN Q86V09_HUMAN ---------------------------------GMVPFIFVGTRENISNAQALLEYHLSY B1H2A6_RAT B1H2A6_RAT ---------------------------------GMVPFIFVGTRENISNAQALLEYHLSY Q3TA75_MOUSE Q3TA75_MOUSE ---------------------------------GMVPFIFVGTRENISNAQALLEYHLSY Q6P5B5_MOUSE Q6P5B5_MOUSE ---------------------------------GMVPFIFVGTRENISNAQALLEYHLSY Q4T723_TETNG Q4T723_TETNG ---------------------------------GMVPFTFVGTKESIDNVQALLDYHISY Q4TCM9_TETNG Q4TCM9_TETNG ---------------------------------------------------------VSV Q9PUN3_DANRE Q9PUN3_DANRE ---------------------------------GMVPFTFVGTKESISNVQVLLEYHIAY Q6NUW6_DANRE Q6NUW6_DANRE ---------------------------------GMVPFTFVGTKESISNVQVLLEYHIAY Q7SXA0_DANRE Q7SXA0_DANRE ---------------------------------GMVPFTFVGTKESISNVQVLLEYHIAY Q4TCP2_TETNG Q4TCP2_TETNG ---------------------------------GMVPFTFVGTKESI------------- FXR1B_XENLA FXR1B_XENLA ---------------------------------GMVPFVFVGTKENIGNVQVLLEYHIAY A3KMH8_XENLA A3KMH8_XENLA ---------------------------------GMVPFVFVGTKENIGNVQVLLEYHIAY FXR1A_XENLA FXR1A_XENLA ---------------------------------GMVPFVFVGTKENIGNVQVLLEYHIAY FXR1_XENTR FXR1_XENTR ---------------------------------GMVPFVFVGTKESIGNVQVLLEYHIAY Q0VFT5_XENTR Q0VFT5_XENTR ---------------------------------GMVPFVFVGTKESIGNVQVLLEYHIAY Q5F3S6_CHICK Q5F3S6_CHICK ---------------------------------GMVPFVFVGTKESIGNVQVLLEYHIAY FXR1_CRIGR FXR1_CRIGR ---------------------------------GMVPFVFVGTKESIGNVQVLLEYHIAY FXR1_MOUSE FXR1_MOUSE ---------------------------------GMVPFVFVGTKESIGNVQVLLEYHIAY FXR1_BOVIN FXR1_BOVIN ---------------------------------GMVPFVFVGTKESIGNVQVLLEYHIAY B4DM78_HUMAN B4DM78_HUMAN ---------------------------------GMVPFVFVGTKESIGNVQVLLEYHIAY B4DXZ6_HUMAN B4DXZ6_HUMAN ---------------------------------GMVPFVFVGTKESIGNVQVLLEYHIAY FXR1_HUMAN FXR1_HUMAN ---------------------------------GMVPFVFVGTKESIGNVQVLLEYHIAY Q4R9A3_MACFA Q4R9A3_MACFA ---------------------------------GMVPFVFVGTKESIGNVQVLLEYHIAY Q4R3K8_MACFA Q4R3K8_MACFA ----------------------------------MVPFVFVGTKESIGNVQVLLEYHIAY B4DGH9_HUMAN B4DGH9_HUMAN ---------------------------------GMVPFVFVGTKESIGNVQVLLEYHIAY Q5R8Z2_PONAB Q5R8Z2_PONAB ---------------------------------GMVPFVFVGTKESIGNVQVLLEYHIAY A6QLG6_BOVIN A6QLG6_BOVIN ---------------------------------GMVPFVFVGTKESIGNVQVLLEYHIAY Q5R8Y7_PONAB Q5R8Y7_PONAB ---------------------------------GMVPFVFVGTKESIGNVQVLLEYHIAY B4DM21_HUMAN B4DM21_HUMAN ---------------------------------GMVPFVFVGTKESIGNVQVLLEYHIAY FXR1_RAT FXR1_RAT ---------------------------------GMVPFVFVGTKESIGNVQVLLEYHIAY Q8C7U4_MOUSE Q8C7U4_MOUSE ---------------------------------GMVPFVFVGTKESIGNVQVLLEYHIAY MATCH CONSENSUS ?????????????????????????????????G?VPF?FVGT???I?N???LL?YH??Y

Q0V9Q1_XENTR Q0V9Q1_XENTR IS-----------------------LLKPLRVGSLQIDQPLQQNSVC------------- Q4SFA2_TETNG Q4SFA2_TETNG LK-----------------------EVDQLHLERLHIDEQLRQFGGAGAGPRM------- Q4TFI5_TETNG Q4TFI5_TETNG LKRRSKEENRFGQRSGSDGPSCHQQEVDQLHLERLHIDEQLRQFGGAGAGPRM------- Q7SYM7_DANRE Q7SYM7_DANRE LK-----------------------EVDQLRMERLQIDEQLRQIGGGPRALPGRPE---- Q9DF20_DANRE Q9DF20_DANRE LK-----------------------EVDQLRMERLQIDEQLRQIGGGPRALPGRPE---- FMR1_XENTR FMR1_XENTR LK-----------------------EVDQLRLERLQIDEQLRQIGASSRPPPNRPD---- FMR1B_XENLA FMR1B_XENLA LK-----------------------EVDQLRLERLQIDEQLRQIGASSRPPSNRPD---- B7ZRL0_XENLA B7ZRL0_XENLA LK-----------------------EVDQLRLERLQIDEQLRQIGASSRPPPNRPD---- FMR1A_XENLA FMR1A_XENLA LK-----------------------EVDQLRLERLQIDEQLRHIGASSRPPPNRPD---- B6CVD8_TAEGU B6CVD8_TAEGU LK-----------------------EVDQLRLERLQIDEQLRQIGATSRPPPNRTD---- Q0II33_BOVIN Q0II33_BOVIN ------------------------------------------------------------ Q59GC1_HUMAN Q59GC1_HUMAN LK-----------------------EVDQLRLERLQIDEQLRQIGASSRPPPNRTD---- FMR1_PONAB FMR1_PONAB LK-----------------------EVDQLRLERLQIDEQLRQIGASSRPPPNRTD---- FMR1_HUMAN FMR1_HUMAN LK-----------------------EVDQLRLERLQIDEQLRQIGASSRPPPNRTD---- A8MQB8_HUMAN A8MQB8_HUMAN LK-----------------------EVDQLRLERLQIDEQLRQIGASSRPPPNRTD---- A6NNH4_HUMAN A6NNH4_HUMAN LK-----------------------EVDQLRLERLQIDEQLRQIGASSRPPPNRTD---- Q8IXW7_HUMAN Q8IXW7_HUMAN ------------------------------------------------------------ Q547R0_MOUSE Q547R0_MOUSE LK-----------------------EVDQLRLERLQIDEQLRQIGASSRPPPNRTD---- FMR1_MOUSE FMR1_MOUSE LK-----------------------EVDQLRLERLQIDEQLRQIGASSRPPPNRTD---- FMR1_RAT FMR1_RAT LK-----------------------EVDQLRLERLQIDEQLRQIGASSRPPPNRTD---- Q6AXB7_MOUSE Q6AXB7_MOUSE LK-----------------------EVDQLRLERLQIDEQLRQIGASSRPPPNRTD---- Q8BPK8_MOUSE Q8BPK8_MOUSE -------------------------EI---------------------MPPSSLPS---- Q8BPN5_MOUSE Q8BPN5_MOUSE ------------------------------------------------------------ Q8VD80_RAT Q8VD80_RAT ------------------------------------------------------------ Q4T116_TETNG Q4T116_TETNG LQ-----------------------EMEQLYMERLQIDDQLRQIGVGYRAPSSRGP---G Q6NY99_DANRE Q6NY99_DANRE LQ-----------------------EVEQLRLERLQIDEQLRQIGVGYRAPPSRSGSGVA Q7ZV52_DANRE Q7ZV52_DANRE LQ-----------------------EVEQLRLERLQIDEQLRQIGVGYRAPPSRSGSGVA FXR2_MOUSE FXR2_MOUSE LQ-----------------------EVETLRLERLQIDEQLRQIGAGFRPPGSGRGGSGG FXR2_HUMAN FXR2_HUMAN LQ-----------------------EVEQLRLERLQIDEQLRQIGLGFRPPGSGRG--SG Q86V09_HUMAN Q86V09_HUMAN LQ-----------------------EVEQLRLERLQIDEQLRQIGLGFRPPGSGRG--SG B1H2A6_RAT B1H2A6_RAT LQ-----------------------EVEQLRLERLQIDEQLRQIGLGFRPPGSGRGGSGG Q3TA75_MOUSE Q3TA75_MOUSE LQ-----------------------EVEQLRLERLQIDEQLRQIGLGFRPPGSGRGGSGG Q6P5B5_MOUSE Q6P5B5_MOUSE LQ-----------------------EVEQLRLERLQIDEQLRQIGLGFRPPGSGRGGSGG Q4T723_TETNG Q4T723_TETNG LN-------VSRVRLGWRLGLGGPEEVEQLRLERLQIDEQLRQLTQGHRPAEREREERGE Q4TCM9_TETNG Q4TCM9_TETNG LK---------------------------------------------------------- Q9PUN3_DANRE Q9PUN3_DANRE LN-----------------------EVEQLRLERLQIDEQLRQIGMGFRSVPNRPA---- Q6NUW6_DANRE Q6NUW6_DANRE LN-----------------------EVEQLRLERLQIDEQLRQIGMGFRSVPNRPA---- Q7SXA0_DANRE Q7SXA0_DANRE LN-----------------------EVEQLRLERLQIDEQLRQIGMGFRSVPNRPA---- Q4TCP2_TETNG Q4TCP2_TETNG ------------------------------------------------------------ FXR1B_XENLA FXR1B_XENLA LK-----------------------EVEQLRMERLQIDEQLRQIGMGFRPSSRGTE---- A3KMH8_XENLA A3KMH8_XENLA LK-----------------------EVEQLRMERLQIDEQLRQIGMGFRPSSSRGT---- FXR1A_XENLA FXR1A_XENLA LK-----------------------EVEQLRMERLQIDEQLRQIGMGFRPSSSRGT---- FXR1_XENTR FXR1_XENTR LK-----------------------EVEQLRMERLQIDEQLRQIGMGFRPSSSRGT---- Q0VFT5_XENTR Q0VFT5_XENTR LK-----------------------EVEQLRMERLQIDEQLRQIGMGFRPPSSRGT---- Q5F3S6_CHICK Q5F3S6_CHICK LK-----------------------EVEQLRLERLQIDEQLRQIGMGFRPSSARVP---- FXR1_CRIGR FXR1_CRIGR LK-----------------------EVEQLRMERLQIDEQLRQIG--------------- FXR1_MOUSE FXR1_MOUSE LK-----------------------EVEQLRMERLQIDEQLRQIGMGFRPSSTRGP---- FXR1_BOVIN FXR1_BOVIN LK-----------------------EVEQLRMERLQIDEQLRQIG--------------- B4DM78_HUMAN B4DM78_HUMAN LK-----------------------EVEQLRMERLQIDEQLRQIGMGFRPSSTRGP---- B4DXZ6_HUMAN B4DXZ6_HUMAN LK-----------------------EVEQLRMERLQIDEQLRQIG--------------- FXR1_HUMAN FXR1_HUMAN LK-----------------------EVEQLRMERLQIDEQLRQIG--------------- Q4R9A3_MACFA Q4R9A3_MACFA LK-----------------------EVEQLRMERLQIDEQLRQIG--------------- Q4R3K8_MACFA Q4R3K8_MACFA LK-----------------------EVEQLRMERLQIDEQLRQIG--------------- B4DGH9_HUMAN B4DGH9_HUMAN LK-----------------------EVEQLRMERLQIDEQLRQIG--------------- Q5R8Z2_PONAB Q5R8Z2_PONAB LK-----------------------EVEQLRMERLQIDEQLRQIG--------------- A6QLG6_BOVIN A6QLG6_BOVIN LK-----------------------EVEQLRMERLQIDEQLRQIG--------------- Q5R8Y7_PONAB Q5R8Y7_PONAB LK-----------------------EVEQLRMERLQIDERLRQIG--------------- B4DM21_HUMAN B4DM21_HUMAN LK-----------------------EVEQLRMERLQIDEQLRQIG--------------- FXR1_RAT FXR1_RAT LK-----------------------EVEQLRMERLQIDEQLRQIGMGFRPSSTRGP---- Q8C7U4_MOUSE Q8C7U4_MOUSE LK-----------------------EVEQLRMERLQIDEQLRQIG--------------- MATCH CONSENSUS L????????????????????????EV?QLR?ERLQIDEQLRQIG???????????????

Q0V9Q1_XENTR Q0V9Q1_XENTR -------------------------------------------PTH-------------- Q4SFA2_TETNG Q4SFA2_TETNG -PKEKHFLLDNGVDPG-------SGRGAGRGHGGGGGGGEAAMAS--------------- Q4TFI5_TETNG Q4TFI5_TETNG -PKEKHFLLDNGVDPG-------SGRGAGRGHGGGGGG-GEAAMAS-------------- Q7SYM7_DANRE Q7SYM7_DANRE --KEKSFMADNGM---------------GPSRGG----------GY-------------- Q9DF20_DANRE Q9DF20_DANRE --KEKSFMADNGMGPSRGGGKPFGRG--GRGRRGPTLA-----S---------------- FMR1_XENTR FMR1_XENTR --KEKGYQSEDLSGTG-RGSRPYNNR--GRSRRGTGYA-----SDIRYGDPDYRKTTYPE FMR1B_XENLA FMR1B_XENLA --KEKGYLSEDCSGT-VRGSRPYNNR--GRSRRGTGYA-----S---------------- B7ZRL0_XENLA B7ZRL0_XENLA --KEKGYLSEDCSGT-VRGSRPYSNR--GRSRRGTGYA-----S---------------- FMR1A_XENLA FMR1A_XENLA --KEKGYLSEDCSGT-VRGSRPYSNR--GRSRRGTGYA-----S---------------- B6CVD8_TAEGU B6CVD8_TAEGU --KDKGYMTDDGPGLG-RGSRPYRNR--GHSRRGPGYA-----S---------------- Q0II33_BOVIN Q0II33_BOVIN ------------------------------------------------------------ Q59GC1_HUMAN Q59GC1_HUMAN --KEKSYVTDDGQGMG-RGSRPYRNR--GHGRRGPGYT-----S---------------- FMR1_PONAB FMR1_PONAB --KEKSYVTDDGQGMG-RGSRPYRNR--GHGRRGPGYT-----S---------------- FMR1_HUMAN FMR1_HUMAN --KEKSYVTDDGQGMG-RGSRPYRNR--GHGRRGPGYT-----S---------------- A8MQB8_HUMAN A8MQB8_HUMAN --KEKSYVTDDGQGMG-RGSRPYRNR--GHGRRGPGYT---------------------- A6NNH4_HUMAN A6NNH4_HUMAN --KEKSYVTDDGQGMG-RGSRPYRNR--GHGRRGPGYT---------------------- Q8IXW7_HUMAN Q8IXW7_HUMAN ------------------------------------------------------------ Q547R0_MOUSE Q547R0_MOUSE --KEKGYVTDDGQGMG-RGSRPYRNR--GHGRRGPGYT---------------------- FMR1_MOUSE FMR1_MOUSE --KEKGYVTDDGQGMG-RGSRPYRNR--GHGRRGPGYT-----S---------------- FMR1_RAT FMR1_RAT --KEKGYVTDDGQGMG-RGSRPYRNR--GHGRRGPGYT-----S---------------- Q6AXB7_MOUSE Q6AXB7_MOUSE --KEKGYVTDDGQGMG-RGSRPYRNR--GHGRRGPGYT-------S-------------- Q8BPK8_MOUSE Q8BPK8_MOUSE ----------------------------NNSRVGPNSS---------------------- Q8BPN5_MOUSE Q8BPN5_MOUSE ------------------------------------------------------------ Q8VD80_RAT Q8VD80_RAT ------------------------------------------------------------ Q4T116_TETNG Q4T116_TETNG GDRERGYLTDDSN-NSLHTTRNYAPR--GRGHRGANNQ----HSGF-------------- Q6NY99_DANRE Q6NY99_DANRE GERERGYLTDEST-NSLQTTRTYGGR--GRGRKPNNTY-----SGY-------------- Q7ZV52_DANRE Q7ZV52_DANRE GERERGYLTDEST-NSLQTTRTYGGR--GRGRK-PNNTY----SGY-------------- FXR2_MOUSE FXR2_MOUSE GSDKAGYTTDESSSSSLHTTRTYGGSYGGRGRGRRTGG-----PAY-------------- FXR2_HUMAN FXR2_HUMAN GSDKAGYSTDESSSSSLHATRTYGGSYGGRGRGRRTGG-----PAY-------------- Q86V09_HUMAN Q86V09_HUMAN GSDKAGYSTDESSSSSLHATRTYGGSYGGRGRGRRTGG-----PAY-------------- B1H2A6_RAT B1H2A6_RAT GSDKAGYTTDESSSSSLHTTRTYGGSYGGRGRGRRTGG-----PAY-------------- Q3TA75_MOUSE Q3TA75_MOUSE GSDKAGYTTDESSSSSLHTTRTYGGSYGGRGRGRRTGG-----PAY-------------- Q6P5B5_MOUSE Q6P5B5_MOUSE GSDKAGYTTDESSSSSLHTTRTYGGSYGGRGRGRRTGG-----PAY-------------- Q4T723_TETNG Q4T723_TETNG REGYHTDGSANAASSSLHVSRTYNGR--GRGRRGHH-------AGY-------------- Q4TCM9_TETNG Q4TCM9_TETNG ------------------------------------------------------------ Q9PUN3_DANRE Q9PUN3_DANRE -DKEKGFGPDESSSGSIHTQRSYR----GRGRRGPAHT-----SAY-------------- Q6NUW6_DANRE Q6NUW6_DANRE -DKEKGFGPDESSSGSIHTQRSYR----GRGRRGPAHT-----SAY-------------- Q7SXA0_DANRE Q7SXA0_DANRE -DKEKGFGPDESSSGSIHTQRSYR----GRGRRGPAHT-----SAY-------------- Q4TCP2_TETNG Q4TCP2_TETNG ------------------------------------------------------------ FXR1B_XENLA FXR1B_XENLA --KEKGYVTDESAASSVRGSRSYSGR--GRGRRGPNYT-----SGY-------------- A3KMH8_XENLA A3KMH8_XENLA -EKEKGYATDESTASSVRGSRSYSGR--GRGRRGPNYT-----SGY-------------- FXR1A_XENLA FXR1A_XENLA -EKEKGYATDESTASSVRGSRSYSGR--GRGRRGPNYT-----SGY-------------- FXR1_XENTR FXR1_XENTR -EKEKGYATDESTASSVRGSRSYSGR--GRGRRGPNYT-----SGY-------------- Q0VFT5_XENTR Q0VFT5_XENTR ------------------------------------------------------------ Q5F3S6_CHICK Q5F3S6_CHICK -EKEKGYTTDESTLSSVQGSRSYSGR--GRGRRGPSYT-----SGY-------------- FXR1_CRIGR FXR1_CRIGR -------------------SRSYSGR--GRGRRGPNYT-----SGY-------------- FXR1_MOUSE FXR1_MOUSE -EREKGYATDESTVSSVQGSRSYSGR--GRGRRGPNYT-----SGY-------------- FXR1_BOVIN FXR1_BOVIN -------------------SRSYSGR--GRGRRGPNYT-----SGY-------------- B4DM78_HUMAN B4DM78_HUMAN -EKEKGYATDESTVSSVQGSRSYSGR--GRGRRGPNYT-----SGY-------------- B4DXZ6_HUMAN B4DXZ6_HUMAN -------------------SRSYSGR--GRGRRGPNYT-----SGY-------------- FXR1_HUMAN FXR1_HUMAN -------------------SRSYSGR--GRGRRGPNYT-----SGY-------------- Q4R9A3_MACFA Q4R9A3_MACFA -------------------SRSYSGR--GRGRRGPNYT-----SGY-------------- Q4R3K8_MACFA Q4R3K8_MACFA -------------------SRSYSGR--GRGRRGPNYT-----SGY-------------- B4DGH9_HUMAN B4DGH9_HUMAN -------------------SRSYSGR--GRGRRGPNYT-----SGY-------------- Q5R8Z2_PONAB Q5R8Z2_PONAB -------------------SRSYSGR--GRGRRGPNYT-----SGY-------------- A6QLG6_BOVIN A6QLG6_BOVIN -------------------SRSYSGR--GRGRRGPNYT-----SGY-------------- Q5R8Y7_PONAB Q5R8Y7_PONAB -------------------SRSYSGR--GRGRRGPNYT-----SGY-------------- B4DM21_HUMAN B4DM21_HUMAN -------------------SRSYSGR--GRGRRGPNYT-----SGY-------------- FXR1_RAT FXR1_RAT -EKEKGYATDESTVSSVQGSRSYSGR--GRGRRGPNYT-----SGY-------------- Q8C7U4_MOUSE Q8C7U4_MOUSE -------------------SRSYSGR--GRGRRGPNYT-----SGY-------------- MATCH CONSENSUS ????????????????????????????G??R????????????????????????????

Q0V9Q1_XENTR Q0V9Q1_XENTR ----------VANHPDTESGELLSDHEAELLDWSAAPFEE-------------------- Q4SFA2_TETNG Q4SFA2_TETNG ----------GTNSRASNASEASSEHKDELSDWSLAATDEQAPGSGVLPRRTDDRKR--- Q4TFI5_TETNG Q4TFI5_TETNG ----------GTNSRASNASEASSEHKDELSDWSLAATDEQAPGSGVLPRRTDDRKR--- Q7SYM7_DANRE Q7SYM7_DANRE --------------------------KTEDMHWNDS-----------RSRSSRDSKLRP- Q9DF20_DANRE Q9DF20_DANRE ----------GTNSEASNASETESDHRDELSDWSLAPTDEESMG---YPKRAPDGRKRGG FMR1_XENTR FMR1_XENTR YPRSQAFWIKGTNSEASNASETESDHRDELSDWSLAPAEDDRD----NYHRRGDGRRRG- FMR1B_XENLA FMR1B_XENLA ----------GTNSEASNASETESDHRDELSDWSLAPAEDDRD----NYHRRGDGRRRG- B7ZRL0_XENLA B7ZRL0_XENLA ----------GTNSEASNASETESDHRDELSDWSLAPAEDDRD----NYHRRGDGRRRG- FMR1A_XENLA FMR1A_XENLA ----------GTNSEASNASETESDHRDELSDWSLAPAEDDRDN---YHRRG-DGRRRG- B6CVD8_TAEGU B6CVD8_TAEGU ----------GTNSEASNASETESDHRDELSDWSAAPAEEERD----NYLRRGDGRRRGG Q0II33_BOVIN Q0II33_BOVIN ------------------------------------------------------------ Q59GC1_HUMAN Q59GC1_HUMAN ----------GTNSEASNASETESDHRDELSDWSLAPTEEERE----SFLRRGDGRRRGG FMR1_PONAB FMR1_PONAB ----------GTNSEASNASETESDHRDELSDWSLAPTEEERE----SFLRRGDGRRRGG FMR1_HUMAN FMR1_HUMAN ----------GTNSEASNASETESDHRDELSDWSLAPTEEERE----SFLRRGDGRRRGG A8MQB8_HUMAN A8MQB8_HUMAN ---------------------SESDHRDELSDWSLAPTEEERE----SFLRRGDGRRRGG A6NNH4_HUMAN A6NNH4_HUMAN ----------------SAPTEEERES---------------------FLRRG-DGRRRGG Q8IXW7_HUMAN Q8IXW7_HUMAN ------------------------------------------------------------ Q547R0_MOUSE Q547R0_MOUSE ----------------SAPTEEERES---------------------FLRRG-DGRRRRG FMR1_MOUSE FMR1_MOUSE ----------GTNSEASNASETESDHRDELSDWSLAPTEEERE----SFLRRGDGRRRRG FMR1_RAT FMR1_RAT ----------GTNSEASNASETESDHRDELSDWSLAPTEEERE----SFLRRGDGRRRGG Q6AXB7_MOUSE Q6AXB7_MOUSE ----------GTNSEASNASETESDHRDELSDWSLAPTEEERES---FLRRG-DGRRRGG Q8BPK8_MOUSE Q8BPK8_MOUSE -----------------------------------------------EEKKHLD------ Q8BPN5_MOUSE Q8BPN5_MOUSE ------------------------------------------------------------ Q8VD80_RAT Q8VD80_RAT ------------------------------------------------------------ Q4T116_TETNG Q4T116_TETNG ----------VTNSEMSNTSEPEDANEREQRPRGTSGDE-------------RGARR--- Q6NY99_DANRE Q6NY99_DANRE ----------GTNSEMSNASETEDLGDRESRPKGVGADD-------------RGSKR--- Q7ZV52_DANRE Q7ZV52_DANRE ----------GTNSEMSNASETEDLGDRESRPKGVGADD-------------RGSKR--- FXR2_MOUSE FXR2_MOUSE ----------GPSSDPSTASETESEKREESNRAGPGDRD--------PPSRGEESRRRR- FXR2_HUMAN FXR2_HUMAN ----------GPSSDVSTASETESEKREEPNRAGPGDRD--------PPTRGEESRRRPT Q86V09_HUMAN Q86V09_HUMAN ----------GPSSDVSTASETESEKREEPNRAGPGDRD--------PPTRGEESRRRPT B1H2A6_RAT B1H2A6_RAT ----------GPSSDPSTASETESEKREESNRAGPGDRD--------PPSRGEESRRRPI Q3TA75_MOUSE Q3TA75_MOUSE ----------GPSSDPSTASETESEKREESNRAGPGDRD--------PPSRGEESRRRPI Q6P5B5_MOUSE Q6P5B5_MOUSE ----------GPSSDPSTASETESEKREESNRAGPGDRD--------PPSRGEESRRRPI Q4T723_TETNG Q4T723_TETNG ----------GTNLDPANASETDSERRDELSDWSLAGEDQDGER---EPRPQRDARRRPG Q4TCM9_TETNG Q4TCM9_TETNG ----------APLS---------------------------------------------- Q9PUN3_DANRE Q9PUN3_DANRE ----------GTNSEHSYTSETDSERKAELSDWSLAADESER-----NPRPQRDSRRRDM Q6NUW6_DANRE Q6NUW6_DANRE ----------GTNSEHSYTSETDSERKAELSDWSLAADESER-----NPRPQRDSRRRDM Q7SXA0_DANRE Q7SXA0_DANRE ----------GTNSEHSYTSETDSERKAELSDWSLAADESER-----NPRPQRDSRRRDM Q4TCP2_TETNG Q4TCP2_TETNG ------------------------------------------------------------ FXR1B_XENLA FXR1B_XENLA ----------GTNSELSNTSETESERKEELSDWSLAGEDER------EGRQQRDSRRRP- A3KMH8_XENLA A3KMH8_XENLA ----------GTNSELSNPSETESERKEELSDWSLAGEDER------ESRQQRDSRRRP- FXR1A_XENLA FXR1A_XENLA ----------GTNSELSNPSETESERKEELSDWSLAGEDER------ESRQQRDSRRRP- FXR1_XENTR FXR1_XENTR ----------GTNSELSNPSETESERKEELSDWSLAGEDER------ESRQQRDSRRRP- Q0VFT5_XENTR Q0VFT5_XENTR -------------------------------------------------------KKKK- Q5F3S6_CHICK Q5F3S6_CHICK ----------GTNSELSNPSETESERKDELSDWSLAGEDDR------ESRHQRDNRRRP- FXR1_CRIGR FXR1_CRIGR ----------GTNSELSNPSETESERKDELSDWSLAGEDDR------ETRHQRDSRRRP- FXR1_MOUSE FXR1_MOUSE ----------GTNSELSNPSETESERKDELSDWSLAGEDDR------ETRHQRDSRRRP- FXR1_BOVIN FXR1_BOVIN ----------GTNSELSNPSETESERKDELSDWSLAGEDDR------ESRHQRDSRRRP- B4DM78_HUMAN B4DM78_HUMAN ----------GTNSELSNPSETESERKDELSDWSLAGEDDR------DSRHQRDSRRRP- B4DXZ6_HUMAN B4DXZ6_HUMAN ----------GTNSELSNPSETESERKDELSDWSLAGEDDR------DSRHQRDSRRRP- FXR1_HUMAN FXR1_HUMAN ----------GTNSELSNPSETESERKDELSDWSLAGEDDR------DSRHQRDSRRRP- Q4R9A3_MACFA Q4R9A3_MACFA ----------GTNSELSNPSETESERKDELSDWSLAGEDDR------DSRHQRDSRRRP- Q4R3K8_MACFA Q4R3K8_MACFA ----------GTNSELSNPSETESERKDELSDWSLAGEDDR------DSRHQRDSRRRP- B4DGH9_HUMAN B4DGH9_HUMAN ----------GTNSELSNPSETESERKDELSDWSLAGEDDR------DSRHQRDSRRRP- Q5R8Z2_PONAB Q5R8Z2_PONAB ----------GTNSELSNPSETESERKDELSDWSLAGEDDR------DSRHQRDSRRRP- A6QLG6_BOVIN A6QLG6_BOVIN ----------GTNSELSNPSETESERKDELSDWSLAGEDDR------ESRHQRDSRRRP- Q5R8Y7_PONAB Q5R8Y7_PONAB ----------GTNSELSNPSETESERKDELSDWSLAGEDDR------DSRHQRDSRRRP- B4DM21_HUMAN B4DM21_HUMAN ----------GTNSELSNPSETESERKDELSDWSLAGEDDR------DSRRQRDSRRRP- FXR1_RAT FXR1_RAT ----------GTNSELSNPSETESERKDELSDWSLAGEDDR------ETRHQRDSRRRP- Q8C7U4_MOUSE Q8C7U4_MOUSE ----------GTNSELSNPSETESERKDELSDWSLAGEDDR------ETRHQRDSRRRP- MATCH CONSENSUS ????????????????S???E???????E???????????????????????????R???

Q0V9Q1_XENTR Q0V9Q1_XENTR ------------------------------------------------------------ Q4SFA2_TETNG Q4SFA2_TETNG GMKGR----GGRGRGG-------------------------------------------- Q4TFI5_TETNG Q4TFI5_TETNG GMKGR----GGRGRGGN------------------------------------------- Q7SYM7_DANRE Q7SYM7_DANRE -----------------------QEESLQIRIDSNNE-RSIHTSRSSQAMAGDSGGNRQR Q9DF20_DANRE Q9DF20_DANRE GPRGR----GGRGRGGY-KTEDMHWNDSRSRSSRDSKLRPQEESRQIRIDSNNERSIHTS FMR1_XENTR FMR1_XENTR GPRGQ----GMRGRGGF-KGNDDQ-----PRPDNRQRNSRETKARTSDGSLQIRIDCNNE FMR1B_XENLA FMR1B_XENLA GMRGQ----GMRGRGGF-KGNDDQ-----PRPDNRQRNSRETKARTSDGSLQIRIDCNNE B7ZRL0_XENLA B7ZRL0_XENLA GTRGQ----GMRGRGGF-KGNDDQ-----PRPDNRQRNSRETKARTSDGSLQIRLDCNNE FMR1A_XENLA FMR1A_XENLA GTRGQ----GMRGRGGF-KGNDDQ-----PRPDNRQRNSRETKARTSDGSLQIRLDCNNE B6CVD8_TAEGU B6CVD8_TAEGU GGRGQ----GGRGRGGF-KGNDEQ-----SRTDNRQRNSREAKGRTADG----------- Q0II33_BOVIN Q0II33_BOVIN ------------------------------------------------------------ Q59GC1_HUMAN Q59GC1_HUMAN GGRGQ----GGRGRGGGFKGNDDH-----SRTDNRPRNPREAKGRTTDGSLQIRVDCNNE FMR1_PONAB FMR1_PONAB GGRGQ----GGRGRGGGFEGNDDH-----SRTDNRPRNPREAKGRTTDG----------- FMR1_HUMAN FMR1_HUMAN GGRGQ----GGRGRGGGFKGNDDH-----SRTDNRPRNPREAKGRTTDGSLQIRVDCNNE A8MQB8_HUMAN A8MQB8_HUMAN GGRGQ----GGRGRGGGFKGNDDH-----SRTDNRPRNPREAKGRTTDG----------- A6NNH4_HUMAN A6NNH4_HUMAN GGRGQ----GGRGRGGGFKGNDDH-----SRTDNRPRNPREAKGRTTDGSLQIRVDCNNE Q8IXW7_HUMAN Q8IXW7_HUMAN ------------------------------------------------------------ Q547R0_MOUSE Q547R0_MOUSE GGRGQ----GGRGRGGGFKGNDDH-----SRTDNRPRNPREAKGRTADG----------- FMR1_MOUSE FMR1_MOUSE GGRGQ----GGRGRGGGFKGNDDH-----SRTDNRPRNPREAKGRTADG----------- FMR1_RAT FMR1_RAT GGRGQ----GGRGRGGGFKGNDDH-----SRTDNRPRNPRETKGRTTDG----------- Q6AXB7_MOUSE Q6AXB7_MOUSE GGRGQ----GGRGRGGGFKGNDDH-----SRTDNRPRNPREAKGRTADG----------- Q8BPK8_MOUSE Q8BPK8_MOUSE ------------------------------------------------------------ Q8BPN5_MOUSE Q8BPN5_MOUSE ------------------------------------------------------------ Q8VD80_RAT Q8VD80_RAT ------------------------------------------------------------ Q4T116_TETNG Q4T116_TETNG GARGR-GANTGRGRGGPGSKPSNSISSVLRDPDSNPYSVLEGKGELPDADLSEGAGGRN- Q6NY99_DANRE Q6NY99_DANRE GGRGR-GSSAGRGRGGPGPRNINTISSVLRDPDSNPY-SLLE-GEGEQGGDTDASESMGG Q7ZV52_DANRE Q7ZV52_DANRE GGRGR-GSSAGRGRGGPGPRNINTISSVLRDPDSNPY-SLLEG-EGEQGGDTDASESMGG FXR2_MOUSE FXR2_MOUSE LGPGK--GPPPVPRPTS-RYNSSSISSVLKDPDSNPY-SLLDTSEPEPPVDSEPGEPPPA FXR2_HUMAN FXR2_HUMAN GGRGR--GPPPAPRPTS-RYNSSSISSVLKDPDSNPY-SLLDTSEPEPPVDSEPGEPPPA Q86V09_HUMAN Q86V09_HUMAN GGRGR--GPPPAPRPTS-RYNSSSISSVLKDPDSNPY-SLLDTSEPEPPVDSEPGEPPPA B1H2A6_RAT B1H2A6_RAT GGRGR--GPPPVPRPTS-RYNSSSISSVLKDPDSNPY-SLLDTSEPEPPVDSEPGEPPPA Q3TA75_MOUSE Q3TA75_MOUSE GGRGR--GPPPVPRPTS-RYNSSSISSVLKDPDSNPY-SLLDTSEPEPPVDS-------- Q6P5B5_MOUSE Q6P5B5_MOUSE GGRGR--GPPPVPRPTS-RYNSSSISSVLKDPDSNPY-SLLDTSEPEPPVDSEPGEPPPA Q4T723_TETNG Q4T723_TETNG PGRGRGAGRGGRGRG---RGYSNSFAGPRSSEDNRAYVSLETNTETDQTADTDASESNLS Q4TCM9_TETNG Q4TCM9_TETNG ------------------PGGAAAVSSLLSQPAWRLV----------------------- Q9PUN3_DANRE Q9PUN3_DANRE RGRGR----GSRGRG---SGASNSISSVLKDPDGNPY-SLLDNTETDQTADTDGSESQMN Q6NUW6_DANRE Q6NUW6_DANRE RGRGR----GSRGRG---SGASNSISSVLKDPDGNPY-SLLDNTETDQTADTDGSESQMN Q7SXA0_DANRE Q7SXA0_DANRE RGRGR----GSRGRG---SGASNSISSVLKDPDGNPY-SLLDNTETDQTADTDGSESQMN Q4TCP2_TETNG Q4TCP2_TETNG ------------------------------------------------------------ FXR1B_XENLA FXR1B_XENLA GGRGR-SGSAGRGR<