Alignment of the gene Family HBG005844 of HOVERGEN

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Threshold: 50% 80% 100%
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Isoforms are ON
B3DK55_DANRE B3DK55_DANRE EPQFQTSSSTE-KR-----MENIVGTNSAPTRTDISEKAVASSTTSNEDDSSGSPYHLER Q6U6Z9_DANRE Q6U6Z9_DANRE EPQFQTSSSTE-KR-----MENVVGTNSAPTRTDISEKAVASSTTSNEDDSSGSPYHLER Q4S1H8_TETNG Q4S1H8_TETNG -----------------------------------------------EDDSSGTPFHRER GLI3_XENLA GLI3_XENLA EAQSRSTTASEKKK-----VENSIV--KGHSRTEVSEKAVASSTTSNEDESPGQTYHRER Q9I8Q1_COTCO Q9I8Q1_COTCO EAQSHSSTTTEKKK-----VENSIV--KCSSRTDVSEKAVASSTTSNEDESPGQTYHRER Q9DF31_CHICK Q9DF31_CHICK ------------------------------------------------------------ Q9IA31_CHICK Q9IA31_CHICK EAQSHSSTTTEKKK-----VENSIV--KCSNRTDVSEKAVASSTTSNEDESPGQTYHRER B2RUG4_MOUSE B2RUG4_MOUSE EAQAHSSTATERKK-----AENSIG--KCPTRTDVSEKAVASSTTSNEDESPGQIYHRER GLI3_MOUSE GLI3_MOUSE EAQAHSSTATERKK-----AENSIG--KCPTRTDVSEKAVASSTTSNEDESPGQIYHRER B7ZNV2_MOUSE B7ZNV2_MOUSE EAQAHSSTATERKK-----AENSIG--KCPTRTDVSEKAVASSTTSNEDESPGQIYHRER Q5ISB1_9PRIM Q5ISB1_9PRIM --QSHSSTATEKKK-----VENSIV--KCSTRADVSEKAVASSTTSNEDESPGQTYHRER GLI3_PANTR GLI3_PANTR EAQSHSSTTTEKKK-----VENSIV--KCSTRTDVSEKAVASSTTSNEDESPGQTYHRER B4DRK1_HUMAN B4DRK1_HUMAN ------------------------------------------------------------ GLI3_HUMAN GLI3_HUMAN EAQSHSSTTTEKKK-----VENSIV--KCSTRTDVSEKAVASSTTSNEDESPGQTYHRER Q4SES2_TETNG Q4SES2_TETNG EPVRFSTSEPDLLRRSFRLCNGADGFHFGPERIRYGKRPRASCLRPPLQRRLRRETSKRV B3DGN8_DANRE B3DGN8_DANRE ------------------------------------------------------------ Q5BN24_DANRE Q5BN24_DANRE ------------------------------------------------------------ B0S6T1_DANRE B0S6T1_DANRE ------------------------------------------------------------ Q9YGS4_DANRE Q9YGS4_DANRE ------------------------------------------------------------ Q98SN1_DANRE Q98SN1_DANRE ------------------------------------------------------------ Q4RK76_TETNG Q4RK76_TETNG ------------------------------------------------------------ GLI4_XENLA GLI4_XENLA ------------------------------------------------------------ Q9W6B2_XENLA Q9W6B2_XENLA ------------------------------------------------------------ Q9PSZ4_CHICK Q9PSZ4_CHICK ------------------------------------------------------------ GLI2_HUMAN GLI2_HUMAN ------------------------------------------------------------ Q59FV5_HUMAN Q59FV5_HUMAN ------------------------------------------------------------ Q0VGT2_MOUSE Q0VGT2_MOUSE ------------------------------------------------------------ Q0VGV1_MOUSE Q0VGV1_MOUSE ------------------------------------------------------------ GLI1_XENLA GLI1_XENLA ------------------------------------------------------------ Q4SS75_TETNG Q4SS75_TETNG ------------------------------------------------------------ Q800Z9_DANRE Q800Z9_DANRE ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

B3DK55_DANRE B3DK55_DANRE RNTISAQT-----DVVNTSGK-VSEEPSTSTDERPPLVKKELQSSLHRLADHTLPYRGTL Q6U6Z9_DANRE Q6U6Z9_DANRE RNTISAQT-----DVVNTSGK-VSEEPSTSTDERLPLVKKELQSFLHRLADHTLPYRGTL Q4S1H8_TETNG Q4S1H8_TETNG RNAISSHA-----PTPGGLDRSISEEPSTSTEERPSLLKKELHGSLAHLGDHALPYRGTL GLI3_XENLA GLI3_XENLA RNAIAMQP-----QGGQGLGK-ISEEPSTSSEERASLIKKELHGSITHLPEPSVPYRGTV Q9I8Q1_COTCO Q9I8Q1_COTCO RNAITMQP-----QGGQGLSK-ISEEPSTSSEERASLIKKEIHGSISHLPEPSVPYRGTL Q9DF31_CHICK Q9DF31_CHICK ----------------------------------------------------SVPYRGTL Q9IA31_CHICK Q9IA31_CHICK RNAITMQP-----QGGQGLSK-ISEEPSTSSEERASLIKKEIHGSISHLPEPSVPYRGTL B2RUG4_MOUSE B2RUG4_MOUSE RNAITMQP-----QSVQGLNK-ISEEPSTSSDERASLIKKEIHGSLPHLAEPSLPYRGTV GLI3_MOUSE GLI3_MOUSE RNAITMQP-----QSVQGLNK-ISEEPSTSSDERASLIKKEIHGSLPHLAEPSLPYRGTV B7ZNV2_MOUSE B7ZNV2_MOUSE RNAITMQP-----QSVQGLNK-ISEEPSTSSDERASLIKKEIHGSLPHLAEPSLPYRGTV Q5ISB1_9PRIM Q5ISB1_9PRIM RNAITMQP-----QNVQGLSK-VSEEPSTSSDERASLIKKEIHGSLPHLAEPSVPYRGTV GLI3_PANTR GLI3_PANTR RNAITMQP-----QNVQGLSK-VSEEPSTSSDERASLIKKEIHGSLPHVAEPSVPYRGTV B4DRK1_HUMAN B4DRK1_HUMAN -----MQP-----QNVQGLSK-VSEEPSTSSDERASLIKKEIHGSLPHVAEPSVPYRGTV GLI3_HUMAN GLI3_HUMAN RNAITMQP-----QNVQGLSK-VSEEPSTSSDERASLIKKEIHGSLPHVAEPSVPYRGTV Q4SES2_TETNG Q4SES2_TETNG RGRILSFPTGNVRRSPGGFYAWGRSPPAGIRQGRGPGREKEIGSTVGVRWEH-LDRRGGV B3DGN8_DANRE B3DGN8_DANRE -------------------MEAGVPAPAEKKDCKSSPLEGNVFSEMPKKPSPSSLSRG-- Q5BN24_DANRE Q5BN24_DANRE -------------------MEAGVPAPAEKKDCKSSPLEGNVFSEMPKKPSPSSLSRG-- B0S6T1_DANRE B0S6T1_DANRE -------------------METTSPTSTEKKELKPSVLDGSSFTDLPKKPSPTTASR--- Q9YGS4_DANRE Q9YGS4_DANRE -------------------METTSPTSTEKKELKPSVLDGSSFTDLPKKPSPTTASR--- Q98SN1_DANRE Q98SN1_DANRE ------------------------------------------------------------ Q4RK76_TETNG Q4RK76_TETNG ------------------------------------------------------------ GLI4_XENLA GLI4_XENLA ------------------------------------------------------------ Q9W6B2_XENLA Q9W6B2_XENLA ------------------------------------------------------------ Q9PSZ4_CHICK Q9PSZ4_CHICK -------------------METSASTAAGKKEXKV------------------------- GLI2_HUMAN GLI2_HUMAN ------------------METSASATASEKQEAKSGILEAAGFPDPGKKASPLVVAAAAA Q59FV5_HUMAN Q59FV5_HUMAN ------------------------------------------------------------ Q0VGT2_MOUSE Q0VGT2_MOUSE ------------------METSAPAPALEKKEAKSGLLEDSSFPDPGKKACPLAVAAAVA Q0VGV1_MOUSE Q0VGV1_MOUSE ------------------METSAPAPALEKKEAKSGLLEDSSFPDPGKKACPLAVAAAVA GLI1_XENLA GLI1_XENLA ------------------------------------------------------------ Q4SS75_TETNG Q4SS75_TETNG ------------------------------------------------------------ Q800Z9_DANRE Q800Z9_DANRE ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

B3DK55_DANRE B3DK55_DANRE FAMDPRSGYLDPHY-------------------------------TAPQFFPAF--HHPV Q6U6Z9_DANRE Q6U6Z9_DANRE FAMDLRSGYLDPHY-------------------------------TAPQFFRAF--HHPV Q4S1H8_TETNG Q4S1H8_TETNG FAMDPRNGYLDSHYLRATLRCRQPVSAGGFLVCLLPKWHPHRYVSAAPQFFPTF--HPPV GLI3_XENLA GLI3_XENLA FAMDPRNGYIDPHY------------------------------RSDLDLFPAF--HPPV Q9I8Q1_COTCO Q9I8Q1_COTCO FTMDPRNGYMDPHY------------------------------RDPPHLFPAF--HPPV Q9DF31_CHICK Q9DF31_CHICK FTMDPRNGYMDPHY------------------------------H-PPHLFPAF--HPPV Q9IA31_CHICK Q9IA31_CHICK VTMDPRNGYMDPHY------------------------------H-PPHLFQAF--HPPV B2RUG4_MOUSE B2RUG4_MOUSE FAMDPRNGYMEPHY------------------------------H-PPHLFPAF--HPPV GLI3_MOUSE GLI3_MOUSE FAMDPRNGYMEPHY------------------------------H-PPHLFPAF--HPPV B7ZNV2_MOUSE B7ZNV2_MOUSE FAMDPRNGYMEPHY------------------------------H-PPHLFPAF--HPPV Q5ISB1_9PRIM Q5ISB1_9PRIM FAMDPRNGYMEPHY------------------------------H-PPHLFPAF--HPPV GLI3_PANTR GLI3_PANTR FAMDPRNGYMEPHY------------------------------H-PPHLFPAF--HPPV B4DRK1_HUMAN B4DRK1_HUMAN FAMDPRNGYMEPHY------------------------------H-PPHLFPAF--HPPV GLI3_HUMAN GLI3_HUMAN FAMDPRNGYMEPHY------------------------------H-PPHLFPAF--HPPV Q4SES2_TETNG Q4SES2_TETNG RGVQPGHGGGTVALCRAVA---------------------------PTTSSPPFTRRSRL B3DGN8_DANRE B3DGN8_DANRE ----------------------------------------------PHHIFPTF--HSPI Q5BN24_DANRE Q5BN24_DANRE ----------------------------------------------PHHIFPTF--HSPI B0S6T1_DANRE B0S6T1_DANRE ----------------------------------------------APHLFSTF--HTPI Q9YGS4_DANRE Q9YGS4_DANRE ----------------------------------------------APHLFSTF--HTPI Q98SN1_DANRE Q98SN1_DANRE ------------------------------------------------------------ Q4RK76_TETNG Q4RK76_TETNG ------------------------------------------------------------ GLI4_XENLA GLI4_XENLA ------------------------------------------------------------ Q9W6B2_XENLA Q9W6B2_XENLA ------------------------------------------------------------ Q9PSZ4_CHICK Q9PSZ4_CHICK ----------------------------------------------PQHIFPAF--HAPL GLI2_HUMAN GLI2_HUMAN AAVAAQGV--------------------------------------PQHLLPPF--HAPL Q59FV5_HUMAN Q59FV5_HUMAN ------------------------------------------------------------ Q0VGT2_MOUSE Q0VGT2_MOUSE AHGV------------------------------------------PQQLLPAF--HAPL Q0VGV1_MOUSE Q0VGV1_MOUSE AHGV------------------------------------------PQQLLPAF--HAPL GLI1_XENLA GLI1_XENLA ------------------------------------------------------------ Q4SS75_TETNG Q4SS75_TETNG ------------------------------------------------------------ Q800Z9_DANRE Q800Z9_DANRE -----------------------------------------------------------M MATCH CONSENSUS ????????????????????????????????????????????????????????????

B3DK55_DANRE B3DK55_DANRE PIDDRHTQ---GRYIYEPSPVPSLHM---------------------------------- Q6U6Z9_DANRE Q6U6Z9_DANRE PIDDRHTQ---GRYIYEPSPVPSLHM---------------------------------- Q4S1H8_TETNG Q4S1H8_TETNG PIDDRHTQ---GRYIYEPSPVPPLHVFWYPASHRERIRPLSAPRDEGHFFILLSNCPKRI GLI3_XENLA GLI3_XENLA PIDARHHE---GRYHYEPTPIPPLHV---------------------------------- Q9I8Q1_COTCO Q9I8Q1_COTCO PIDARHHE---GRYHYEPSPIPPLHV---------------------------------- Q9DF31_CHICK Q9DF31_CHICK PIDARHHE---GRYHYEPSPIPPLHV---------------------------------- Q9IA31_CHICK Q9IA31_CHICK PIDARHHE---GRYHYEPSPIPPLHV---------------------------------- B2RUG4_MOUSE B2RUG4_MOUSE PIDARHHE---GRYHYDPSPIPPLHV---------------------------------- GLI3_MOUSE GLI3_MOUSE PIDARHHE---GRYHYDPSPIPPLHV---------------------------------- B7ZNV2_MOUSE B7ZNV2_MOUSE PIDARHHE---GRYHYDPSPIPPLHV---------------------------------- Q5ISB1_9PRIM Q5ISB1_9PRIM PIDARHHE---GRYHYDPSPIPPLHM---------------------------------- GLI3_PANTR GLI3_PANTR PIDARHHE---GRYHYDPSPIPPLHM---------------------------------- B4DRK1_HUMAN B4DRK1_HUMAN PIDARHHE---GRYHYDPSPIPPLHM---------------------------------- GLI3_HUMAN GLI3_HUMAN PIDARHHE---GRYHYDPSPIPPLHM---------------------------------- Q4SES2_TETNG Q4SES2_TETNG TCDITRADTTTSRTRCTPCTEPQIGRKVEPGGKKNPES---------------------- B3DGN8_DANRE B3DGN8_DANRE PIDVRHHE---GRYHYDPHALHALHG---------------------------------- Q5BN24_DANRE Q5BN24_DANRE PIDVRHHE---GRYHYDPHALHALHG---------------------------------- B0S6T1_DANRE B0S6T1_DANRE PIDMRHHE---GRYHYEPHPLHPMHG---------------------------------- Q9YGS4_DANRE Q9YGS4_DANRE PIDMRHHE---GRYHYEPHPLHPMHG---------------------------------- Q98SN1_DANRE Q98SN1_DANRE ------------------------------------------------------------ Q4RK76_TETNG Q4RK76_TETNG ------------------------------------------------------------ GLI4_XENLA GLI4_XENLA ------------------------------------------------------------ Q9W6B2_XENLA Q9W6B2_XENLA ------------------------------------------------------------ Q9PSZ4_CHICK Q9PSZ4_CHICK PIDMRHQE---GRYHYEPHSIHAIHG---------------------------------- GLI2_HUMAN GLI2_HUMAN PIDMRHQE---GRYHYEPHSVHGVHG---------------------------------- Q59FV5_HUMAN Q59FV5_HUMAN ------------------------------------------------------------ Q0VGT2_MOUSE Q0VGT2_MOUSE PIDMRHQE---GRYHSDPHSVHSVHG---------------------------------- Q0VGV1_MOUSE Q0VGV1_MOUSE PIDMRHQE---GRYHYDPHSVHSVHG---------------------------------- GLI1_XENLA GLI1_XENLA ---------------MASRQCPPAAV---------------------------------- Q4SS75_TETNG Q4SS75_TETNG --------------MYNPMTSAIAHG---------------------------------- Q800Z9_DANRE Q800Z9_DANRE PVDMQPHQ---GLYHYDNTSNQPSRG---------------------------------- MATCH CONSENSUS ????????????????????????????????????????????????????????????

B3DK55_DANRE B3DK55_DANRE --------PPALAASPTFSDISLIRISPHRNPSMGTDSPFNPSHPYINPYMD--YIRSLH Q6U6Z9_DANRE Q6U6Z9_DANRE --------PPALAASPTFSDISLIRISPHRNPSMGTDSPFNPSHPYINPYMD--YIRSLH Q4S1H8_TETNG Q4S1H8_TETNG RWNFGGRRPPALAGSPAFSDISLIRISPQRNPSVGAESPFHPPHPYISPYMD--YIRSLH GLI3_XENLA GLI3_XENLA --------PTALASSPTYPDLPFFRISPHRNPASASDSPFSPPHPYISPYMD--YIRSLH Q9I8Q1_COTCO Q9I8Q1_COTCO --------PSALSSSPTYSDLPFIRISPHRNSAAASESPFSTPHPYINPYMD--YIRSLH Q9DF31_CHICK Q9DF31_CHICK --------PSALSSSPTYSDLPFIRISPHRNPAAASESPFSTPHPYINPYMD--YIRSLH Q9IA31_CHICK Q9IA31_CHICK --------PSALSSSPTYSDLPFIRISPHRNPAAASESPFSTPHPYINPYMD--YIRSLH B2RUG4_MOUSE B2RUG4_MOUSE --------PSALSSSPTYPDLPFIRISPHRNPTAASESPFSPPHPYINPYMD--YIRSLH GLI3_MOUSE GLI3_MOUSE --------PSALSSSPTYPDLPFIRISPHRNPTAASESPFSPPHPYINPYMD--YIRSLH B7ZNV2_MOUSE B7ZNV2_MOUSE --------PSALSSSPTYPDLPFIRISPHRNPTAASESPFSPPHPYINPYMD--YIRSLH Q5ISB1_9PRIM Q5ISB1_9PRIM --------PSALSSSPTYPDLPFIRISPHRNPAAASESPFSPPHPYINPYMD--YIRSLH GLI3_PANTR GLI3_PANTR --------TSALSSSPTYPDLPFIRISPHRNPAAASESPFSPPHPYINPYMD--YIRSLH B4DRK1_HUMAN B4DRK1_HUMAN --------TSALSSSPTYPDLPFIRISPHRNPAAASESPFSPPHPYINPYMD--YIRSLH GLI3_HUMAN GLI3_HUMAN --------TSALSSSPTYPDLPFIRISPHRNPAAASESPFSPPHPYINPYMD--YIRSLH Q4SES2_TETNG Q4SES2_TETNG --------PAALAGSPVVSDISLLRLSP------AADSPFVPAHPYVGPHVEH-YLRSMH B3DGN8_DANRE B3DGN8_DANRE --------PPGLAGSPVISDISLIRLSP-----GAAGEAFLPPHSYVSPHVEH-YLRSAH Q5BN24_DANRE Q5BN24_DANRE --------PPGLAGSPVISDISLIRLSP-----GAAGEAFLPPHSYVSPHVEH-YLRSAH B0S6T1_DANRE B0S6T1_DANRE --------PHGLAGSPVISDISLIRLSPH--AAATGESPFNPPHPYVNPHMEH-YLRSVH Q9YGS4_DANRE Q9YGS4_DANRE --------PHGLAGSPVISDISLIRLSPH--AAATGESPFNPPHPYVNPHMEH-YLRSVH Q98SN1_DANRE Q98SN1_DANRE -----------------ISDISLIRLSPH--AAATGESPFNPPHPYVNPHMEH-YLRSVH Q4RK76_TETNG Q4RK76_TETNG -----------------------------------------------------------M GLI4_XENLA GLI4_XENLA --------------------------------------------------MEH-YLRSVH Q9W6B2_XENLA Q9W6B2_XENLA --------------------------------------------------MEH-YLRSVH Q9PSZ4_CHICK Q9PSZ4_CHICK --------PPPLSGSPVISDISLIRLSPH--PAGPGESPFSPPHPYLTPHMEH-YLRSVH GLI2_HUMAN GLI2_HUMAN --------PPALSGSPVISDISLIRLSPH--PAGPGESPFNAPHPYVNPHMEH-YLRSVH Q59FV5_HUMAN Q59FV5_HUMAN ------------------------------------------------------------ Q0VGT2_MOUSE Q0VGT2_MOUSE --------PPTLSGSPVISDISLIRLSPH--PAGPGESPFSAHHPYVNPHMEH-YLRSVH Q0VGV1_MOUSE Q0VGV1_MOUSE --------PPTLSGSPFISDISLIRLSPH--PAGPGESPFSAHHPYVNPHMEH-YLRSVH GLI1_XENLA GLI1_XENLA ---------------------------------------FNSMNPPVNSYVEHCYLRSPN Q4SS75_TETNG Q4SS75_TETNG --------------------------------AGTG----------IGLCTDQ-YMRPPQ Q800Z9_DANRE Q800Z9_DANRE --------LAPSVRSPYSSEASSVCVALSGGQSVNSREMYNPSMA-PGACMEP-YMRAPH MATCH CONSENSUS ???????????????????????????????????????F??????????????Y?RS?H

B3DK55_DANRE B3DK55_DANRE SSPSLSMVSAARGLSPAD----------------THHTGLTTAEYYHQMALLAGHRSPY- Q6U6Z9_DANRE Q6U6Z9_DANRE SSPSLSMVSAARGLSPAD----------------THHTGLTTAEYYHQMALLVGHRSPY- Q4S1H8_TETNG Q4S1H8_TETNG SSPSISVLSATRGLSPAD----------------APHTGLTTAEYYHQMALLAGHRSPYA GLI3_XENLA GLI3_XENLA SSPSLSMISAARGLSPTD----------------VPHAGISPAEYYHQMALLAGQRSPY- Q9I8Q1_COTCO Q9I8Q1_COTCO SSPSLSMISAARGLSPTD----------------APHAGVSPAEYYHQMALLAGQRSPY- Q9DF31_CHICK Q9DF31_CHICK SSPSLSMISAARGLSPTD----------------APHAGVSPAEYYHQMALLAGQRSPY- Q9IA31_CHICK Q9IA31_CHICK SSPSLSMISAARGLSPTD----------------APHAGVSPAEYYHQMALLAGQRSPY- B2RUG4_MOUSE B2RUG4_MOUSE SSPSLSMISAARGLSPTD----------------APHAGVSPAEYYHQMALLTGQRSPY- GLI3_MOUSE GLI3_MOUSE SSPSLSMISAARGLSPTD----------------APHAGVSPAEYYHQMALLTGQRSPY- B7ZNV2_MOUSE B7ZNV2_MOUSE SSPSLSMISAARGLSPTD----------------APHAGVSPAEYYHQMALLTGQRSPY- Q5ISB1_9PRIM Q5ISB1_9PRIM SSPSLSMISATRGLSPTD----------------APHAGVSPAEYYHQMALLTGQRSPY- GLI3_PANTR GLI3_PANTR SSPSLSMISATRGLSPTD----------------APHAGVSPAEYYHQMALLTGQRSPY- B4DRK1_HUMAN B4DRK1_HUMAN SSPSLSMISATRGLSPTD----------------APHAGVSPAEYYHQMALLTGQRSPY- GLI3_HUMAN GLI3_HUMAN SSPSLSMISATRGLSPTD----------------APHAGVSPAEYYHQMALLTGQRSPY- Q4SES2_TETNG Q4SES2_TETNG GSPALSMIAAARGLSPAELAQEHLKERGLCGA--PPPP---PADFYH---LMSSHRSPY- B3DGN8_DANRE B3DGN8_DANRE SSPTLSMISAARGLSPAEVAHEHLKERGLFGL--PPPPGASPADYYH---LMAGHRNPY- Q5BN24_DANRE Q5BN24_DANRE SSPTLSMISAARGLSPAEVAHEHLKERGLFGL--PPPPGASPADYYH---LMAGHRNPY- B0S6T1_DANRE B0S6T1_DANRE SSPTLSMISAARGLSPAELTHEHLKERSLFGL-PPPPPGANPSEYYH---LIASHRSPY- Q9YGS4_DANRE Q9YGS4_DANRE SSPTLSMISAARGLSPAELTHEHLKERSLFGL-PPPPPGANPSEYYH---LIASHRSPY- Q98SN1_DANRE Q98SN1_DANRE SSPTLSMISAARGLSPAELTHEHLKERSLFGL-PPPPPGANPSEYYH---LIASHRSPY- Q4RK76_TETNG Q4RK76_TETNG AAPRLDAHPA------------------------PRPRGFSTS----------------- GLI4_XENLA GLI4_XENLA NSPTLSMISAARGLSPAEVAHEHLKERGIYGLAPPPPPGTTPTEYCHQMAFLASHASPY- Q9W6B2_XENLA Q9W6B2_XENLA NSPTLSMISAARGLSPAEVAHEHLKERGIFGL-APPPPGTTPTEYCHQMAFLASHASPY- Q9PSZ4_CHICK Q9PSZ4_CHICK GSPTLSVISAARGLSPADVAHEHLKERGLFGL-PPPPPGANPTDYYHQMTLMAGHPN-Y- GLI2_HUMAN GLI2_HUMAN SSPTLSMISAARGLSPADVAQEHLKERGLFGL---PAPGTTPSDYYHQMTLVAGHPAPY- Q59FV5_HUMAN Q59FV5_HUMAN ------------------------------------------------------------ Q0VGT2_MOUSE Q0VGT2_MOUSE SSPTLSMISAARGLSPADVAHEHLKERGLFSL---AAPGTNPSDYYHQMTLMASHPTPY- Q0VGV1_MOUSE Q0VGV1_MOUSE SSPTLSMISAARGLSPADVAHEHLKERGLFSL---AAPGTNPSDYYHQMTLMASHPTPY- GLI1_XENLA GLI1_XENLA ----------------------------------VMAEGMNEMPYCHQTNLMTSHHG-F- Q4SS75_TETNG Q4SS75_TETNG ALPPHSMM-GHRGM--------------------PPPEGGNSTPYCNQSNMMPSHHNFC- Q800Z9_DANRE Q800Z9_DANRE APPPHSMM-GHRGM--------------------PPPEGMSGAPYCNQNMMTSHHNLPH- MATCH CONSENSUS ?SP?LSM?SA?RGLSP??????????????????????G?????Y?H???L??????PY?

B3DK55_DANRE B3DK55_DANRE ADLIPSVGSTTGP-ASSALHM-EYLQAMESSRFPSPRLINRPSRKRPIPNSPSLSDPSFD Q6U6Z9_DANRE Q6U6Z9_DANRE ADLIPSVGSTTGP-ASSALHM-EYLQAMESSRFPSPRLINRPSRKRPIPNSPSLSDPSFD Q4S1H8_TETNG Q4S1H8_TETNG ADLLPSLAATAGASGAAASHV-EYLHAMESSRFSSPRLPSRPSRKRPLPISP-LSEPSFD GLI3_XENLA GLI3_XENLA ADIFPS-PATAGA-GANALHM-EYLHAMESSRFSSPRLSARPSRKRTLSISP-LSDHSFD Q9I8Q1_COTCO Q9I8Q1_COTCO ADIIPS-AATAGA-G--ALHM-EYLHAMDSTRFPSPRLSARPSRKRTLSISP-LSDHSFD Q9DF31_CHICK Q9DF31_CHICK ADIIPS-AATAGA-G--ALHM-EYLHAMDSTRFPSPRLSARPSRKRTLSISP-LSDHSFD Q9IA31_CHICK Q9IA31_CHICK ADIIPS-AATAGA-G--ALHM-EYLHAMDSTRFPSPRLSARPSRKRTLSISP-LSDHSFD B2RUG4_MOUSE B2RUG4_MOUSE ADILPS-AATAGA-G--AIHM-EYLHAMDSTRFPSPRLSARPSRKRTLSISP-LSDHSFD GLI3_MOUSE GLI3_MOUSE ADILPS-AATAGA-G--AIHM-EYLHAMDSTRFPSPRLSARPSRKRTLSISP-LSDHSFD B7ZNV2_MOUSE B7ZNV2_MOUSE ADILPS-AATAGA-G--AIHM-EYLHAMDSTRFPSPRLSARPSRKRTLSISP-LSDHSFD Q5ISB1_9PRIM Q5ISB1_9PRIM ADIIPS-AATAGT-G--AIHM-EYLHAMDSTRFPSPRLSARPSRKRTLSISP-LSDHSFD GLI3_PANTR GLI3_PANTR ADIIPS-AATAGT-G--AIHM-EYLHAMDSTRFPSPRLSARPSRKRTLSISP-LSDHSFD B4DRK1_HUMAN B4DRK1_HUMAN ADIIPS-AATAGT-G--AIHM-EYLHAMDSTRFSSPRLSARPSRKRTLSISP-LSDHSFD GLI3_HUMAN GLI3_HUMAN ADIIPS-AATAGT-G--AIHM-EYLHAMDSTRFSSPRLSARPSRKRTLSISP-LSDHSFD Q4SES2_TETNG Q4SES2_TETNG GDLLMHGGGASA-----GAHLSDYITPID-----APRLTPRLGRKRALSISP-LSDASID B3DGN8_DANRE B3DGN8_DANRE GELLMQGAGAAAA----AAHLPEYFTSVDVSRFPSPRMTPRLSRKRALSISP-LSDASID Q5BN24_DANRE Q5BN24_DANRE GELLMQGAGAAAA----AAHLPEYFTSVDVSRFPSPRMTPRLSRKRALSISP-LSDASID B0S6T1_DANRE B0S6T1_DANRE GDLLMQTGAA-------AAHLPDYMSPVDMSRFPSPRLTPRVSRKRALSISP-VSDASID Q9YGS4_DANRE Q9YGS4_DANRE GDLLMQTGAA-------AAHLPDYMSPVDMSRFPSPRLTPRVSRKRALSISP-VSDASID Q98SN1_DANRE Q98SN1_DANRE GDLLMQTGAA-------AAHLPDYMSPVDMSRFPSPRLTPRVSRKRALSISP-VSDASID Q4RK76_TETNG Q4RK76_TETNG -----------------------------VSRFSSPRLTPRLSRKRALSISP-LSDASID GLI4_XENLA GLI4_XENLA GELLVQ-SAAAGN----TSHLHDYLTPMDVSRFSSPRVTPRLSRKRALSISP-LSDASID Q9W6B2_XENLA Q9W6B2_XENLA GELLVQ-SAAAGN----TSHLHDYLTPMDVSRFSSPRVTPRLSRKRALSISP-LSDASID Q9PSZ4_CHICK Q9PSZ4_CHICK GDILMQSGGAAG-----TAHLHEYLSPVDVSRFSSPRVTPRLSRKRALSISP-LSDASID GLI2_HUMAN GLI2_HUMAN GDLLMQSGGAAS-----APHLHDYLNPVDVSRFSSPRVTPRLSRKRALSISP-LSDASLD Q59FV5_HUMAN Q59FV5_HUMAN ------------------------------------------------------------ Q0VGT2_MOUSE Q0VGT2_MOUSE GDLLMQSGGAAS-----APHLHDYLNPVDASRFSSPRVTPRLSRKRALSISP-LSDASLD Q0VGV1_MOUSE Q0VGV1_MOUSE GDLLMQSGGAAS-----APHLHDYLNPVDASRFSSPRVTPRLSRKRALSISP-LSDASLD GLI1_XENLA GLI1_XENLA -------GLAQGS---------DHLAGTDGSRFSTPRSTMKLSKKRAMSISP-LSDASID Q4SS75_TETNG Q4SS75_TETNG -------QAQGNS---------DQIGSGDGSRFSTPRSMLKLSKKRALSISP-LSDASVD Q800Z9_DANRE Q800Z9_DANRE -----------------NQHTSELMASGDASCFSTPRSMLKLSKKRALSISP-LSDASVD MATCH CONSENSUS ???????????????????H???Y????D??RF?SPR???R?SRKR?LSISP?LSD?S?D

B3DK55_DANRE B3DK55_DANRE LQAMIRTSPNSLVTILNNSRSSSSNSGSYGHLSAGTISPALSFAYPPTPVAL-QMHQQLI Q6U6Z9_DANRE Q6U6Z9_DANRE LQAMIRTSPNSLVTILNNSRSSSSNSGSYGHLSAGTISPALSFAYPPTPVAL-QMHQQLI Q4S1H8_TETNG Q4S1H8_TETNG LQTMIRNSPNSLVNILNNSRSSSSTSGSYGHLSAGAISPALSFAYPPTPVAL-HVHQQLM GLI3_XENLA GLI3_XENLA LQTMIRNSPNSLVTILNNSRSSSSASGSYGHLAASAISPALNFAYQPTPVSLQQMHQQIM Q9I8Q1_COTCO Q9I8Q1_COTCO LQTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYPPTPVSLQQMHQQII Q9DF31_CHICK Q9DF31_CHICK LQTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYPPTPVSLQQMHQQII Q9IA31_CHICK Q9IA31_CHICK LQTMIRTSPNSLVTILNNSCSSWSASGSYGHLSASAISPALSFTYPPTPVSLQQMHQQII B2RUG4_MOUSE B2RUG4_MOUSE LQTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYPSAPVSL-HMHQQIL GLI3_MOUSE GLI3_MOUSE LQTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYPSAPVSL-HMHQQIL B7ZNV2_MOUSE B7ZNV2_MOUSE LQTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYPSAPVSL-HMHQQIL Q5ISB1_9PRIM Q5ISB1_9PRIM LQTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYSSAPVSL-HMHQQIL GLI3_PANTR GLI3_PANTR LQTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYSSAPVSL-HMHQQIL B4DRK1_HUMAN B4DRK1_HUMAN LQTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYSSAPVSL-HMHQQIL GLI3_HUMAN GLI3_HUMAN LQTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYSSAPVSL-HMHQQIL Q4SES2_TETNG Q4SES2_TETNG LQTMIRTSPSSLVAYINNSRSSSAASSSYGHLSVGGLSL--------------------- B3DGN8_DANRE B3DGN8_DANRE LQTMIRTSPNSLVAYINNSRSSSAASSSYGHLSVGGISPSFPFPHSINPVAY----QQLL Q5BN24_DANRE Q5BN24_DANRE LQTMIRTSPNSLVAYINNSRSSSAASSSYGHLSVGGISPSFPFPHSINPVAY----QQLL B0S6T1_DANRE B0S6T1_DANRE LQTMIRTSPNSLVAYINNSRSSSAASSSYGHLSVGAISPSFTFPHPITPVAY----HQLL Q9YGS4_DANRE Q9YGS4_DANRE LQTMIRTSPNSLVAYINNSRSSSAASSSYGHLSVGAISPSFTFPHPITPVAY----HQLL Q98SN1_DANRE Q98SN1_DANRE LQTMIRTSPNSLVAYINNSRSSSAASSSYGHLSVGAISPSFTFPHPITPVAY----HQLL Q4RK76_TETNG Q4RK76_TETNG LQTMIRTSPNSLVAYINNSRSSSAASSSYGHLSVG------------------------- GLI4_XENLA GLI4_XENLA LQTMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGAISPAFSFPIH-KPCSL----SAAL Q9W6B2_XENLA Q9W6B2_XENLA LQTMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGAISPAFSFPHPINPVAY----QQLL Q9PSZ4_CHICK Q9PSZ4_CHICK LQTMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGTISPAFSFPHPINPVTY----QQIL GLI2_HUMAN GLI2_HUMAN LQRMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGALSPAFTFPHPINPVAY----QQIL Q59FV5_HUMAN Q59FV5_HUMAN ------------------------------------------------------------ Q0VGT2_MOUSE Q0VGT2_MOUSE LQRMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGALSPAFTFPHPINPVAY----QQIL Q0VGV1_MOUSE Q0VGV1_MOUSE LQRMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGALSPAFTFPHPINPVAY----QQIL GLI1_XENLA GLI1_XENLA LQTMIRTSPNSLVAFI-NSRCSS-ASGSYGHLSIGTISPSLGY-------------QNCL Q4SS75_TETNG Q4SS75_TETNG LQTVIRTSPNSLVAFV-NSRGNANGASSYGHLSVGAMSPSLGYTSNISCQSR---QQGSL Q800Z9_DANRE Q800Z9_DANRE LQTVIRTSPNSLVAFV-NSRCGPNNPSSYGHLSVGTMSPSLGFSSSIN-----------Y MATCH CONSENSUS LQTMIRTSPNSLV???NNSRSSS?AS?SYGHLS????SP???F?????P???????????

B3DK55_DANRE B3DK55_DANRE SRQPGIVGSAFGHSPPLMHSAPA-FSTQRPVPAIQTSSLAPTERSIV-SNDSQ------- Q6U6Z9_DANRE Q6U6Z9_DANRE SRQPGIVGSAFGHSPPLMHSALA-FSTQRPVPAIQTSSLAPTERSIV-SNDSQ------- Q4S1H8_TETNG Q4S1H8_TETNG GRQPSIVGSAFGHSPPLIHPSPA-FTTQRPVPGIPASGISASERSAI-SSDSSQ------ GLI3_XENLA GLI3_XENLA SRQHSI-GSAFGHSPPLLHPAPT-FPSQRTIPGIPSV-LNPVQVSIG-PSEAAQQ----- Q9I8Q1_COTCO Q9I8Q1_COTCO SRQQTL-GSAFGHSPPLIHPAPT-FPTQRPIPGIPSV-LNPVQVSSG-PSESTQQ----- Q9DF31_CHICK Q9DF31_CHICK SRQQTL-GSAFGHSPPLIHPAPT-FPTQRPIPGIPSV-LNPVQVSSG-PSESTQQ----- Q9IA31_CHICK Q9IA31_CHICK SRQQTL-GSAFGHSPPLIHPAPT-FPTQRPIPGIPSV-LNPVQVSSG-PSESTQH----- B2RUG4_MOUSE B2RUG4_MOUSE SRQQSL-GSAFGHSPPLIHPAPT-FPTQRPIPGIPTV-LNPVQVSSG-PSESSQ------ GLI3_MOUSE GLI3_MOUSE SRQQSL-GSAFGHSPPLIHPAPT-FPTQRPIPGIPTV-LNPVQVSSG-PSESSQ------ B7ZNV2_MOUSE B7ZNV2_MOUSE SRQQSL-GSAFGHSPPLIHPAPT-FPTQRPIPGIPTV-LNPVQVSSG-PSESSQ------ Q5ISB1_9PRIM Q5ISB1_9PRIM SRQQSL-GSAFGHSPPLIHPAPT-FPTQRPIPGIPTV-LNPVQVSSG-PSESSQ------ GLI3_PANTR GLI3_PANTR SRQQSL-GSAFGHSPPLIHPAPT-FPTQRPIPGIPTV-LNPVQVSSG-PSESSQ------ B4DRK1_HUMAN B4DRK1_HUMAN SRQQSL-GSAFGHSPPLIHPAPT-FPTQRPIPGIPTV-LNPVQVSSG-PSESSQ------ GLI3_HUMAN GLI3_HUMAN SRQQSL-GSAFGHSPPLIHPAPT-FPTQRPIPGIPTV-LNPVQVSSG-PSESSQ------ Q4SES2_TETNG Q4SES2_TETNG --------------------TPA-FGAHQPGLGLSRP-LTSAPNSNL-SA---------- B3DGN8_DANRE B3DGN8_DANRE TQQRGL--SAFGHTPPLIQPSPT-FSSRHPLSLSTL--PTPTTNDTE------------T Q5BN24_DANRE Q5BN24_DANRE TQQRGL--SAFGHTPPLIQPSPT-FSSRHPLSLSTL--PTPTTNDTE-T----------- B0S6T1_DANRE B0S6T1_DANRE SQQRGL--NAFGHTPPLLQPSPA-LSSRQQTLVAAAA-LNNTTSSST-SSSTADTSTESS Q9YGS4_DANRE Q9YGS4_DANRE SQQRGL--NAFGHTPPLLQPSPA-LSSRQQTLVAAAA-LNNTTSSST-SSSTADTSTESS Q98SN1_DANRE Q98SN1_DANRE SQQRGL--NAFGHTPPLLQPSPA-LSSRQQTLVAAAA-LNNTTSSST-SSSTADTSTESS Q4RK76_TETNG Q4RK76_TETNG ------------------------------------------------------------ GLI4_XENLA GLI4_XENLA SQQRSL-SSSFGHT-PLLHPSPT-FASRQQGALTSAN-PAPPSNNSSAPDSVL------- Q9W6B2_XENLA Q9W6B2_XENLA SQQRSL--SSFGHT-PLLHPSPT-FASRQQGVLTSAN-PAPPSNNNN-PDSIL------- Q9PSZ4_CHICK Q9PSZ4_CHICK TQQRGL-SSAFGHTPPLIQPSPT-FPPRQHMAVISVN-PPPAQISSN-SNCISDSSQ--- GLI2_HUMAN GLI2_HUMAN SQQRGL-GSAFGHTPPLIQPSPT-FLAQQPMALTSIN-ATPTQLSSS-SNCLSDTNQ--- Q59FV5_HUMAN Q59FV5_HUMAN ------------------------------------------------------------ Q0VGT2_MOUSE Q0VGT2_MOUSE SQQRGL-GSAFGHTPPLIQPSPT-FLAQQPMTLTSIS-TMPTQLSSSSSNCLNDANQ--- Q0VGV1_MOUSE Q0VGV1_MOUSE SQQRGL-GSAFGHTPPLIQPSPT-FLAQQPMTLTSIS-TMPTQLSSSSSNCLNDANQ--- GLI1_XENLA GLI1_XENLA NHQRPQ-AGPYGSNPLMP------YNSHEHLSSRGMSMLQPRSSVKH------------- Q4SS75_TETNG Q4SS75_TETNG YGGGGV--TPLGHTPGPCQGSR--LPPHNPRLHAPPK-HGHLKT---------------- Q800Z9_DANRE Q800Z9_DANRE SRPQG---NIYSHPVPSCIGAPARLPPHNPRLHTPAK----------------------H MATCH CONSENSUS ??Q???????FGH?PPL????P??????????????????????????????????????

B3DK55_DANRE B3DK55_DANRE SKPTSESAVSSTGDPM-NHKRSKLKPEEEPPSPRAVSM--QEQMNG-------------- Q6U6Z9_DANRE Q6U6Z9_DANRE SKPTSESAVSSTGDPM-NHKRSKLKPEEEPPSPRAVSM--QEQMNG-------------- Q4S1H8_TETNG Q4S1H8_TETNG TKPTSESAVSSTGDPM-HHKRSKMKPEEELPSPGAVSI--QDHPDG-------------- GLI3_XENLA GLI3_XENLA NKPTSESAVSSTGDLL-HNKRSKVKPEEDHPSPGAVCI--QDQPDG-------------- Q9I8Q1_COTCO Q9I8Q1_COTCO NKPTSESAVSSTGDPM-HNKRSKIKPDEDLPSPGAGSV--QEQPEG-------------- Q9DF31_CHICK Q9DF31_CHICK NKPTSESAVSSTGDPM-HNKRSKIKPDEDLPSPGAGSV--QEQPEG-------------- Q9IA31_CHICK Q9IA31_CHICK NKPTSESAVSSTGDPM-HNKRSKIKPDEDLPSPGAGSV--QEQPEG-------------- B2RUG4_MOUSE B2RUG4_MOUSE SKPTSESAVSSTGDPM-HNKRSKIKPDEDLPSPGSRGQ--QEQPEG-------------- GLI3_MOUSE GLI3_MOUSE SKPTSESAVSSTGDPM-HNKRSKIKPDEDLPSPGSRGQ--QEQPEG-------------- B7ZNV2_MOUSE B7ZNV2_MOUSE SKPTSESAVSSTGDPM-HNKRSKIKPDEDLPSPGSRGQ--QEQPEG-------------- Q5ISB1_9PRIM Q5ISB1_9PRIM NKPTSESAVSSTGDPM-HNKRSKIKPDEDLPSPGARGQ--QEQPEG-------------- GLI3_PANTR GLI3_PANTR NKPTSESAVSSTGDPM-HNKRSKIKPDEDLPSPGARGQ--QEQPEG-------------- B4DRK1_HUMAN B4DRK1_HUMAN NKPTSESAVSSTGDPM-HNKRSKIKPDEDLPSPGARGQ--QEQPEG-------------- GLI3_HUMAN GLI3_HUMAN NKPTSESAVSSTGDPM-HNKRSKIKPDEDLPSPGARGQ--QEQPEG-------------- Q4SES2_TETNG Q4SES2_TETNG KHLSGDLAVSSTIDPL-ITKRSKVKTEAEGRRSSSPSS--PSRHGS-------------- B3DGN8_DANRE B3DGN8_DANRE KNSNGESAVSSTVNPL-GNKRSKVKTELGGPRPVSPYS--PEHLSS-------------- Q5BN24_DANRE Q5BN24_DANRE KNSNGESAVSSTVNPL-GNKRSKVKTELGGPRPVSPYS--PEHLSS-------------- B0S6T1_DANRE B0S6T1_DANRE QNAGGDPAVSSTVNPM-IFKRSKVKTEAEGPHPISPGS--QDHL---------------- Q9YGS4_DANRE Q9YGS4_DANRE QNAGGDPAVSSTVNPM-IFKRSKVKTEAEGPHPISPGS--QDHL---------------- Q98SN1_DANRE Q98SN1_DANRE QNAGGDPAVSSTVNPM-IFKRSKVKTEAEGPHPISPGS--QDHL---------------- Q4RK76_TETNG Q4RK76_TETNG -----------------------------------PGI--RNPVGG-------------- GLI4_XENLA GLI4_XENLA NKVSSESAVSSTVNQV-IHKRSKVKTEEEADSVRFPQP--PDHL---------------- Q9W6B2_XENLA Q9W6B2_XENLA NKVSSESAVSSTVNQV-IHKRNKVKTEEEVLQRDSPSP--PDHL---------------- Q9PSZ4_CHICK Q9PSZ4_CHICK SKQSSESAVSSTVNPV-INKRTKVKTEVEGLPQYPQPR--QEHL---------------- GLI2_HUMAN GLI2_HUMAN NKQSSESAVSSTVNPVAIHKRSKVKTEPEGLRPASPLALTQGQVSGHGSCGCALPLSQEQ Q59FV5_HUMAN Q59FV5_HUMAN ------------------------------------------------------------ Q0VGT2_MOUSE Q0VGT2_MOUSE NKQNSESAVSSTVNPITIHKRSKVKTEAEGLRPASPLGLTQEQL---------------- Q0VGV1_MOUSE Q0VGV1_MOUSE NKQNSESAVSSTVNPITIHKRSKVKTEAEGLRPASPLGLTQEQL---------------- GLI1_XENLA GLI1_XENLA CQLKSEPLSITGLDTI-GSKRLEDGSEGDISSPASVGT--QDPLLG-------------- Q4SS75_TETNG Q4SS75_TETNG -----EPGLSSVMDGM-NVKSLEERSEGDVASPSSTGT--QDPLLG-------------- Q800Z9_DANRE Q800Z9_DANRE THLKTEPVLGSVMDSI-NIKGLEDHSEGDVASPSSTGT--QDPLLG-------------- MATCH CONSENSUS ?????E?AVSST???????KR?K?K???????P???????????????????????????

B3DK55_DANRE B3DK55_DANRE MTLVKEEGDKEEGKQEPE-VVYETNCHWDGCCREFDTQEQLVH----------------- Q6U6Z9_DANRE Q6U6Z9_DANRE MTLVKEEGDKEEGKQEPE-VVYETNCHWDGCCREFDTQEQLVH----------------- Q4S1H8_TETNG Q4S1H8_TETNG MTLVKEEGDKDENKQEPE-VVYETNCHWENCCREFDTQEQLVQVRHKRQVQRRLVGDVGG GLI3_XENLA GLI3_XENLA MTLVKEEGVKDESKQEAE-VVYETNCHWEGCSREFDTQEQLVH----------------- Q9I8Q1_COTCO Q9I8Q1_COTCO MTLVKEEGDKDENKQEPE-VVYETNCHWEGCSREFDTQEQLVH----------------- Q9DF31_CHICK Q9DF31_CHICK MTPVKEEGDKDESKQEPE-VVYETNCHWEGCSREFDTQEQLVH----------------- Q9IA31_CHICK Q9IA31_CHICK MTPVKEEGDKDESKQEPE-VVYETNCHWEGCSREFDTQEQLVH----------------- B2RUG4_MOUSE B2RUG4_MOUSE TTLVKEEADKDESKQEPE-VIYETNCHWEGCTREFDTQDQLVH----------------- GLI3_MOUSE GLI3_MOUSE TTLVKEEADKDESKQEPE-VIYETNCHWEGCTREFDTQDQLVH----------------- B7ZNV2_MOUSE B7ZNV2_MOUSE TTLVKEEADKDESKQEPE-VIYETNCHWEGCTREFDTQDQLVH----------------- Q5ISB1_9PRIM Q5ISB1_9PRIM TTLVKEEGDKDESKQEPE-VIYETNCHWEGCTREFDTQEQLVH----------------- GLI3_PANTR GLI3_PANTR TTLVKEEGDKDESKQEPE-VIYETNCHWEGCAREFDTQEQLVH----------------- B4DRK1_HUMAN B4DRK1_HUMAN TTLVKEEGDKDESKQEPE-VIYETNCHWEGCAREFDTQEQLVH----------------- GLI3_HUMAN GLI3_HUMAN TTLVKEEGDKDESKQEPE-VIYETNCHWEGCAREFDTQEQLVH----------------- Q4SES2_TETNG Q4SES2_TETNG SLDLKDEADADDCKQELE-AVYETSCRWDGCSREYDTQEQLVH----------------- B3DGN8_DANRE B3DGN8_DANRE AQDLKEDMD--DCKQEAE-LVYETNCHWEGCSKEYDTQEQLVH----------------- Q5BN24_DANRE Q5BN24_DANRE AQDLKEDMD--DCKQEAE-LVYETNCHWEGCSKEYDTQEQLVH----------------- B0S6T1_DANRE B0S6T1_DANRE --ELREELDKDECKQEPE-AVYETNCHWEGCAKEYDTQDQLVH----------------- Q9YGS4_DANRE Q9YGS4_DANRE --ELREELDKDECKQEPE-AVYETNCHWEGCAKEYDTQDQLVH----------------- Q98SN1_DANRE Q98SN1_DANRE --ELREELDKDECKQEPE-AVYETNCHWEGCAKEYDTQDQLVH----------------- Q4RK76_TETNG Q4RK76_TETNG ILDLSEDLDKDECKQEPE-AVYETNCHWEGCTKEYETQEQLVH----------------- GLI4_XENLA GLI4_XENLA -TDLKEDLDKDECKQEPE-HIYETNCHWDGCSKEFDTQDQLVH----------------- Q9W6B2_XENLA Q9W6B2_XENLA -TDLKEDLDKDECKQEPD-IIYETNCHWDGCSKEFDTQDQLVH----------------- Q9PSZ4_CHICK Q9PSZ4_CHICK -TDLKEDLDKDECKQEPE-VIYETNCHWEGCTKEYDTQEQLVH----------------- GLI2_HUMAN GLI2_HUMAN LADLKEDLDRDDCKQEAEVVIYETNCHWEDCTKEYDTQEQLVH----------------- Q59FV5_HUMAN Q59FV5_HUMAN ------------------------------------------------------------ Q0VGT2_MOUSE Q0VGT2_MOUSE -ADLKEDLDRDDCKQEAEVVIYETNCHWADCTKEYDTQEQLVH----------------- Q0VGV1_MOUSE Q0VGV1_MOUSE -ADLKEDLDRDDCKQEAEGVIYETNCHWADCTKEYDTQEQLVH----------------- GLI1_XENLA GLI1_XENLA LLDGRDDLEKDDGKHEPE-TVYETNCHWESCTKEFDTQEHLVH----------------- Q4SS75_TETNG Q4SS75_TETNG LLDGRDDLDKEDGKPEQE-AIYETNCHWESCNKEFDTQDQLVH----------------- Q800Z9_DANRE Q800Z9_DANRE LLEGRDDLDKEE-KPEPE-AIYETNCHWESCSKEFDTQEQLVH----------------- MATCH CONSENSUS ?????E??D????KQE?E???YETNCHW??C??E?DTQ?QLVH?????????????????

B3DK55_DANRE B3DK55_DANRE -------------------HINNDHIHGEKKEFVCRWEECSREQKPFKAQYMLVVHMRRH Q6U6Z9_DANRE Q6U6Z9_DANRE -------------------HINNDHIHGEKKEFVCRWEECSREQKPFKAQYMLVVHMRRH Q4S1H8_TETNG Q4S1H8_TETNG AALSLFSDEELALHAEAAAHINNDHIHGEKKEFVCRWEDCSREQKPFKAQYMLVVHMRRH GLI3_XENLA GLI3_XENLA -------------------HINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRH Q9I8Q1_COTCO Q9I8Q1_COTCO -------------------HINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRH Q9DF31_CHICK Q9DF31_CHICK -------------------HINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRH Q9IA31_CHICK Q9IA31_CHICK -------------------HINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRH B2RUG4_MOUSE B2RUG4_MOUSE -------------------HINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRH GLI3_MOUSE GLI3_MOUSE -------------------HINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRH B7ZNV2_MOUSE B7ZNV2_MOUSE -------------------HINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRH Q5ISB1_9PRIM Q5ISB1_9PRIM -------------------HINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRH GLI3_PANTR GLI3_PANTR -------------------HINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRH B4DRK1_HUMAN B4DRK1_HUMAN -------------------HINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRH GLI3_HUMAN GLI3_HUMAN -------------------HINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRH Q4SES2_TETNG Q4SES2_TETNG -------------------HINNDHIHGEKKEFVCRWDECSREQKPFKAQYMLVVHMRRH B3DGN8_DANRE B3DGN8_DANRE -------------------HINNEHIHGEKKEFVCRWDECSREQKPFKAQYMLVVHMRRH Q5BN24_DANRE Q5BN24_DANRE -------------------HINNEHIHGEKKEFVCRWDECSREQKPFKAQYMLVVHMRRH B0S6T1_DANRE B0S6T1_DANRE -------------------HISNDHIHGEKKEFVCRWVECSREQKPFKAQYMLVVHMRRH Q9YGS4_DANRE Q9YGS4_DANRE -------------------HISNDHIHGEKKEFVCRWVECSREQKPFKAQYMLVVHMRRH Q98SN1_DANRE Q98SN1_DANRE -------------------HISNDHIHGEKKEFVCRWVECSREQKPFKAQYMLVVHMRRH Q4RK76_TETNG Q4RK76_TETNG -------------------HINNDHIHGEKKEFVCRWEECSREQKPFKAQYMLVVHMRRH GLI4_XENLA GLI4_XENLA -------------------HINNDHIHGEKKEFVCRWQDCSREQKPFKAQYMLVVHMRRH Q9W6B2_XENLA Q9W6B2_XENLA -------------------HINNDHIHGEKKEFVCRWQECSREQKPFKAQYMLVVHMRRH Q9PSZ4_CHICK Q9PSZ4_CHICK -------------------HINNDHIHGEKKEFVCRWQDCTREQKPFKAQYMLVVHMRRH GLI2_HUMAN GLI2_HUMAN -------------------HINNEHIHGEKKEFVCRWQACTREQKPFKAQYMLVVHMRRH Q59FV5_HUMAN Q59FV5_HUMAN ----------------------------EKKEFVCRWQACTREQKPFKAQYMLVVHMRRH Q0VGT2_MOUSE Q0VGT2_MOUSE -------------------HINNEHIHGEKKEFVCRWQACTREQKPFKAQYMLVVHMRRH Q0VGV1_MOUSE Q0VGV1_MOUSE -------------------HINNEHIHGEKKEFVCRWQACTREQKPFKAQYMLVVHMRRH GLI1_XENLA GLI1_XENLA -------------------HINNEHIHGEKKEFVCHWQDCSRELRPFKAQYMLVVHMRRH Q4SS75_TETNG Q4SS75_TETNG -------------------HINNEHIHGEKKEFVCHWQDCSREQRPFKAQYMLVVHMRRH Q800Z9_DANRE Q800Z9_DANRE -------------------HINNEHIHGEKKEFVCHWKDCSREQRPFKAQYMLVVHMRRH MATCH *******:* *:** :*************** CONSENSUS ???????????????????HINN?HIHGEKKEFVCRW??CSREQKPFKAQYMLVVHMRRH

B3DK55_DANRE B3DK55_DANRE TGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT Q6U6Z9_DANRE Q6U6Z9_DANRE TGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT Q4S1H8_TETNG Q4S1H8_TETNG TGEKPHKCTFEGCAKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT GLI3_XENLA GLI3_XENLA TGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT Q9I8Q1_COTCO Q9I8Q1_COTCO TGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT Q9DF31_CHICK Q9DF31_CHICK TGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT Q9IA31_CHICK Q9IA31_CHICK TGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT B2RUG4_MOUSE B2RUG4_MOUSE TGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT GLI3_MOUSE GLI3_MOUSE TGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT B7ZNV2_MOUSE B7ZNV2_MOUSE TGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT Q5ISB1_9PRIM Q5ISB1_9PRIM TGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT GLI3_PANTR GLI3_PANTR TGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT B4DRK1_HUMAN B4DRK1_HUMAN TGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT GLI3_HUMAN GLI3_HUMAN TGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT Q4SES2_TETNG Q4SES2_TETNG TGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT B3DGN8_DANRE B3DGN8_DANRE TGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT Q5BN24_DANRE Q5BN24_DANRE TGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT B0S6T1_DANRE B0S6T1_DANRE TGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT Q9YGS4_DANRE Q9YGS4_DANRE TGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT Q98SN1_DANRE Q98SN1_DANRE TGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT Q4RK76_TETNG Q4RK76_TETNG TGEKPHKCT--GCSKAYSRLENLKTHLRSHTGEKPYLCEHEGCNKAFSNASDRAKHQNRT GLI4_XENLA GLI4_XENLA TGEKPHKCTFEGCFKAYSRLENLKTHLRSHTGEKPYVCDHEGCNKAFSNASDRAKHQNRT Q9W6B2_XENLA Q9W6B2_XENLA TGEKPHKCTFEGCFKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT Q9PSZ4_CHICK Q9PSZ4_CHICK TGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT GLI2_HUMAN GLI2_HUMAN TGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT Q59FV5_HUMAN Q59FV5_HUMAN TGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT Q0VGT2_MOUSE Q0VGT2_MOUSE TGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT Q0VGV1_MOUSE Q0VGV1_MOUSE TGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT GLI1_XENLA GLI1_XENLA TGEKPHKCTFEGCNKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT Q4SS75_TETNG Q4SS75_TETNG TGEKPHKCTFEGCNKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT Q800Z9_DANRE Q800Z9_DANRE TGEKPHKCTFEGCNKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT MATCH ********* ** **********************:*:********************* CONSENSUS TGEKPHKCTFEGC?KAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT

B3DK55_DANRE B3DK55_DANRE HSNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEA Q6U6Z9_DANRE Q6U6Z9_DANRE HSNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEA Q4S1H8_TETNG Q4S1H8_TETNG HSNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEA GLI3_XENLA GLI3_XENLA HSNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEA Q9I8Q1_COTCO Q9I8Q1_COTCO HSNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEA Q9DF31_CHICK Q9DF31_CHICK HSNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEA Q9IA31_CHICK Q9IA31_CHICK HSNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEA B2RUG4_MOUSE B2RUG4_MOUSE HSNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEA GLI3_MOUSE GLI3_MOUSE HSNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEA B7ZNV2_MOUSE B7ZNV2_MOUSE HSNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEA Q5ISB1_9PRIM Q5ISB1_9PRIM HSNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEA GLI3_PANTR GLI3_PANTR HSNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEA B4DRK1_HUMAN B4DRK1_HUMAN HSNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEA GLI3_HUMAN GLI3_HUMAN HSNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEA Q4SES2_TETNG Q4SES2_TETNG HSNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEA B3DGN8_DANRE B3DGN8_DANRE HSNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEA Q5BN24_DANRE Q5BN24_DANRE HSNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEA B0S6T1_DANRE B0S6T1_DANRE HSNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEA Q9YGS4_DANRE Q9YGS4_DANRE HSNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEA Q98SN1_DANRE Q98SN1_DANRE HSNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEA Q4RK76_TETNG Q4RK76_TETNG HSNEVGPQLAAMPCSVHPNSELESPSFQKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEA GLI4_XENLA GLI4_XENLA HSNE------------------------KPYICKVPGCTKRYTDPSSLRKHVKTVHGPEA Q9W6B2_XENLA Q9W6B2_XENLA HSNE------------------------KPYICKIPGCTKRYTDPSSLRKHVKTVHGPEA Q9PSZ4_CHICK Q9PSZ4_CHICK HSNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPDA GLI2_HUMAN GLI2_HUMAN HSNE------------------------KPYICKIPGCTKRYTDPSSLRKHVKTVHGPDA Q59FV5_HUMAN Q59FV5_HUMAN HSNE------------------------KPYICKIPGCTKRYTDPSSLRKHVKTVHGPDA Q0VGT2_MOUSE Q0VGT2_MOUSE HSNE------------------------KPYICKIPGCTKRYTDPSSLRKHVKTVHGPDA Q0VGV1_MOUSE Q0VGV1_MOUSE HSNE------------------------KPYICKIPGCTKRYTDPSSLRKHVKTVHGPDA GLI1_XENLA GLI1_XENLA HSNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEA Q4SS75_TETNG Q4SS75_TETNG HSNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEA Q800Z9_DANRE Q800Z9_DANRE HSNE------------------------KPYICKIPGCTKRYTDPSSLRKHVKTVHGPEA MATCH **** ***:**:***********************:* CONSENSUS HSNE????????????????????????KPY?CKIPGCTKRYTDPSSLRKHVKTVHGPEA

B3DK55_DANRE B3DK55_DANRE HVTKKQRGETYPRPPPQPREPGATT--------------DQKEYTHATSKQDECLQVKSI Q6U6Z9_DANRE Q6U6Z9_DANRE HVTKKQRGETYPRPPPQPREPGATT--------------DQKEYTHATSKQDECLQVKSI Q4S1H8_TETNG Q4S1H8_TETNG HVTKKQRGDY-PRPPPQPREPGSNGQGRSPGQLPLGGYTDQREYTHSTSKPEECLQVKSI GLI3_XENLA GLI3_XENLA HVTKKQRGDIHPRPPP-PREPGSHSQSRSPGQQTQGIHGEHKDLSNTTSKHEECLQVRSV Q9I8Q1_COTCO Q9I8Q1_COTCO HVTKKQRGDIHPRPPP-PRDPGSHSQTRSPGQQTQGATGEQKDLNNTTSRREECLQVKAV Q9DF31_CHICK Q9DF31_CHICK HVTKKQRGDIHPRPPP-PRDPGSHSQTRSPGQQTQGATGEQKDLNSTTSRREECLQVKAV Q9IA31_CHICK Q9IA31_CHICK HVTKKQRGDIHPRPPP-PRDPGSHSQTRSPGQQTQGATGEQKDLNSTTSRREECLQVKAV B2RUG4_MOUSE B2RUG4_MOUSE HVTKKQRGDMHPRPPP-PRDSGSHSQSRSPGRPTQGAFGEQKELSNTTSKREECLQVKTV GLI3_MOUSE GLI3_MOUSE HVTKKQRGDMHPRPPP-PRDSGSHSQSRSPGRPTQGAFGEQKELSNTTSKREECLQVKTV B7ZNV2_MOUSE B7ZNV2_MOUSE HVTKKQRGDMHPRPPP-PRDSGSHSQSRSPGRPTQGAFGEQKELSNTTSKREECLQVKTV Q5ISB1_9PRIM Q5ISB1_9PRIM HVTKKQRGDIHPRPPP-PRDSGSHSQSRSPGRPTQGALGEQQDLSNTTSKREECLQVKTV GLI3_PANTR GLI3_PANTR HVTKKQRGDIHPRPPP-PRDSGSHSQSRSPGRPTQGALGEQQDLSNTTSKREECLQVKTV B4DRK1_HUMAN B4DRK1_HUMAN HVTKKQRGDIHPRPPP-PRDSGSHSQSRSPGRPTQGALGEQQDLSNTTSKREECLQVKTV GLI3_HUMAN GLI3_HUMAN HVTKKQRGDIHPRPPP-PRDSGSHSQSRSPGRPTQGALGEQQDLSNTTSKREECLQVKTV Q4SES2_TETNG Q4SES2_TETNG HVTKKQRSDLMPRPPG-PGDNSENDAGTRE-----RLQREKMLDNGSPRGAEDYLHARCI B3DGN8_DANRE B3DGN8_DANRE HVTKKQRGDLPSRPHP-PKENGENEAGAKMA-------EEKIEANSTTRGVEDYLQVKSI Q5BN24_DANRE Q5BN24_DANRE HVTKKQRGDLPSRPHP-PKENGENEAGAKMA-------EEKIEANSTTRGVEDYLQVKSI B0S6T1_DANRE B0S6T1_DANRE HVTKKQRGDAPPKPHP-PKGNGENEAHTKHVR---GRTDGSGEANSTTRGVEDCQHVKTI Q9YGS4_DANRE Q9YGS4_DANRE HVTKKQRGDAPPKPHP-PKGNGENEAHTKHVR---GRTDGSGEANSTTRGVEDCQHVKTI Q98SN1_DANRE Q98SN1_DANRE HVTKKQRGDAPPKPHP-PKGNGENEAHTKHVR---GRTDGSGEANSTTRGVEDCQHVKTI Q4RK76_TETNG Q4RK76_TETNG HVTKKQRSDMAPRPQP-PKGNGVNEANSRHGA---KGVEGKLEANSTSGGMENCLQIKSI GLI4_XENLA GLI4_XENLA HVTKKHRNDIIQKPSL-PKENGDNEASAKLSG--------REHSDSVSRDQEHCLQTRTI Q9W6B2_XENLA Q9W6B2_XENLA HVTKKYRNDIIQKPSV-PKENGDNEASAKLSS--------REHSSSTYRDSEDCLQARTI Q9PSZ4_CHICK Q9PSZ4_CHICK HVTKKQRNDVHPRPPP-LKENGDNEASAKQSS---KVSEESPEANSTTRSMEDCLQVKTI GLI2_HUMAN GLI2_HUMAN HVTKKQRNDVHLRTPL-LKENGDSEAGTEPGG------PESTEASSTSQAVEDCLHVRAI Q59FV5_HUMAN Q59FV5_HUMAN HVTKKQRNDVHLRTPL-LKENGDSEAGTEPGG------PESTEASSTSQAVEDCLHVRAI Q0VGT2_MOUSE Q0VGT2_MOUSE HVTKKQRNDVHVRAPL-LKENGDNEASAEPGG---RGPEESVEASSTSHTVEDCLHIKAI Q0VGV1_MOUSE Q0VGV1_MOUSE HVTKKQRNDVHVRAPL-LKENGDNEASAEPGG---RGPEESVEASSTSHTVEDCLHIKAI GLI1_XENLA GLI1_XENLA HITKKHRGDGMLRAQPGHEGPGNQNVKG----------ENQLDMEASSACKEDG---RLA Q4SS75_TETNG Q4SS75_TETNG HITKKHRGDTGPRPPGSAMTPGGQSS--------------ELLLEKEEARRDDC---KLM Q800Z9_DANRE Q800Z9_DANRE HITKKHRGDTGPRPPG-LTTAGQSS---------------ELLIEKEERNREDC---KLL MATCH *:*** *.: :. . :. : CONSENSUS HVTKKQR?D???RP???????G?????????????????????????????E?CL?????

B3DK55_DANRE B3DK55_DANRE KTEKPMTSQSSPGSQSSCSSDQSING--PHVSQGVQLTVNSIGLAGEVAMLEDMENEEED Q6U6Z9_DANRE Q6U6Z9_DANRE KTEKPMTSQSSPGSQSSCSSDQSING--PHVSQGVQLTVNSIGLAGEVAMLEDMENEEED Q4S1H8_TETNG Q4S1H8_TETNG KTEKPMTSQPSPGGQSTCSSDQSPVSTHPYG--RVQLAVSAGRSPGEGLEESEEKEENEE GLI3_XENLA GLI3_XENLA KTEKPMSSQPSPGGKSSCSRQQSPIS--NYTNSGIELNLNSGGSIGDFSALDET------ Q9I8Q1_COTCO Q9I8Q1_COTCO KSEKPMTSQPSPGGQSTCSNEQSPIS--NYSNNGIELTLTGGSSVGDLSVIDET------ Q9DF31_CHICK Q9DF31_CHICK KSEKPMTSQPSPGGQSTCSSEQSPIS--NYSNNGIELTLTGGGSVGDLSVIDET------ Q9IA31_CHICK Q9IA31_CHICK KSEKPMTSQPSPGGQSTCSSEQSPIS--NYSNNGIELTLTGGGSVGDLSVIDET------ B2RUG4_MOUSE B2RUG4_MOUSE KAEKPMTSQPSPGGQSSCSSQQSPIS--NYSNSGLELPLTDGGSVADLSAIDET------ GLI3_MOUSE GLI3_MOUSE KAEKPMTSQPSPGGQSSCSSQQSPIS--NYSNSGLELPLTDGGSVADLSAIDET------ B7ZNV2_MOUSE B7ZNV2_MOUSE KAEKPMTSQPSPGGQSSCSSQQSPIS--NYSNSGLELPLTDGGSVADLSAIDET------ Q5ISB1_9PRIM Q5ISB1_9PRIM KAEKPMTSQPSPGGQSSCSSQQSPIS--NYSNSGLELPLTDGGSIGDLSAIDET------ GLI3_PANTR GLI3_PANTR KAEKPMTSQPSPGGQSSCSSQQSPIS--NYSNSGLELPLTDGGSIGDLSAIDET------ B4DRK1_HUMAN B4DRK1_HUMAN KAEKPMTSQPSPGGQSSCSSQQSPIS--NYSNSGLELPLTDGGSIGDLSAIDET------ GLI3_HUMAN GLI3_HUMAN KAEKPMTSQPSPGGQSSCSSQQSPIS--NYSNSGLELPLTDGGSIGDLSAIDET------ Q4SES2_TETNG Q4SES2_TETNG SPALAVSHH--------VAANRHPLGSAANHDSGVEMAVTSGGSLGGLSTPDEL------ B3DGN8_DANRE B3DGN8_DANRE KTENSMMYQSSPGGQSSCSSEPSPLGSASLHGGGVEPAGLSGGSVGDLSALDDV------ Q5BN24_DANRE Q5BN24_DANRE KTENSMMYQSSPGGQSSCSSEPSPLGSASLHGGGVEPAGLSGGSVGDLSALDDV------ B0S6T1_DANRE B0S6T1_DANRE KTENTVMYQSSPGGQSSCSSEPSPLGSATNNDSGVEMAMHSGGSLGDLSALDDT------ Q9YGS4_DANRE Q9YGS4_DANRE KTENTVMYQSSPGGQSSCSSEPSPLGSATNNDSGVEMAMHSGGSLGDLSALDDT------ Q98SN1_DANRE Q98SN1_DANRE KTENTVMYQSSPGGQSSCSSEPSPLGSATNNDSGVEMAMHSGGSLGDLSALDDT------ Q4RK76_TETNG Q4RK76_TETNG KTENSMMYQSSPGGHSSCSSEPSPLGSTNNNDSGVEMAMHSGGSFADLSAQDES------ GLI4_XENLA GLI4_XENLA KTEDNMMHQSSPGGQSSCSSEPSPYGNTNNIDSGVDVSLAWQGSLGDLFGLEET------ Q9W6B2_XENLA Q9W6B2_XENLA KTEDNMMHQSSPGGQSSCSSEPSPYS--NYIDSGVDVSLHGEGSLGDLLGLEET------ Q9PSZ4_CHICK Q9PSZ4_CHICK KTENSVMCQSSPGGQSSCSSEPSPLGSTNNNDSGVEMNMHGGGSLGDLTGWMTR------ GLI2_HUMAN GLI2_HUMAN KTESSGLCQSSPGAQSSCSSEPSPLGSAPNNDSGVEMPGTGPGSLGDLTALDDT------ Q59FV5_HUMAN Q59FV5_HUMAN KTESSGLCQSSPGAQSSCSSEPSPLGSAPNNDSGVEMPGTGPGSLGDLTALDDT------ Q0VGT2_MOUSE Q0VGT2_MOUSE KTESSGLCQSSPGAQSSCSSEPSPLGSAPNNDSGMEMPGTGPGSLGDLTALADT------ Q0VGV1_MOUSE Q0VGV1_MOUSE KTESSGLCQSSPGAQSSCSSEPSPLGSAPNNDSGMEMPGTGPGSLGDLTALADT------ GLI1_XENLA GLI1_XENLA VPDITLKSQPSPGGQSSCSSERSPLGSTNNNDSGVEMNANTGGSFEDLTNLDDI------ Q4SS75_TETNG Q4SS75_TETNG APETSLKSQPSPGGQSSCSSERSPLGSANNNDSGVEMNLNAAGSLEDLTALEDG------ Q800Z9_DANRE Q800Z9_DANRE APDNTLKSQPSPGGQSSCSSERSPLGSANNNDSGVEMNLNAAGSLEDLTTQEDS------ MATCH . : : : . :: CONSENSUS K?E?????Q?SPG?QSSCSS??SP?????????G?E??????GS??DL????????????

B3DK55_DANRE B3DK55_DANRE EENREGEKEDAPIMDSTVS---TATSSAATIVLQTHRSVGRPLR---WMEHVKMERLRQV Q6U6Z9_DANRE Q6U6Z9_DANRE EENREGEKEDAPIMDSTVS---TATSSAATIVLQTHRSVGRPLR---WMEHVKMERLRQV Q4S1H8_TETNG Q4S1H8_TETNG ADEECEEGEQAPIMDSTVS----TAST-AMLALQARRSVGRSLR---WMEHVKMERLKQV GLI3_XENLA GLI3_XENLA -----------PIMDSTIS----TAT--TGLGLHGRRVMTGTK----WMEQIKVEKMKQV Q9I8Q1_COTCO Q9I8Q1_COTCO -----------PIMDSTIS----TAT--TALGLQARRNMTGTK----WMEQVKLERLKQV Q9DF31_CHICK Q9DF31_CHICK -----------PIMDSTIS----TAT--TALGLQARRNMTGTK----WMEQVKLERLKQV Q9IA31_CHICK Q9IA31_CHICK -----------PIMDSTIS----TAT--TALGLQARRNMTGTK----WMEQVKLERLKQV B2RUG4_MOUSE B2RUG4_MOUSE -----------PIMDSTIS----TAT--TALALQARRNPAGTK----WMEHIKLERLKQV GLI3_MOUSE GLI3_MOUSE -----------PIMDSTIS----TAT--TALALQARRNPAGTK----WMEHIKLERLKQV B7ZNV2_MOUSE B7ZNV2_MOUSE -----------PIMDSTIS----TAT--TALALQARRNPAGTK----WMEHIKLERLKQV Q5ISB1_9PRIM Q5ISB1_9PRIM -----------PIMDSTIS----TAT--TALALQARRNPAGTK----WMEHIKLERLKQV GLI3_PANTR GLI3_PANTR -----------PIMDSTIS----TAT--TALALQARRNPAGTK----WMEHVKLERLKQV B4DRK1_HUMAN B4DRK1_HUMAN -----------PIMDSTIS----TAT--TALALQARRNPAGTK----WMEHVKLERLKQV GLI3_HUMAN GLI3_HUMAN -----------PIMDSTIS----TAT--TALALQARRNPAGTK----WMEHVKLERLKQV Q4SES2_TETNG Q4SES2_TETNG -----------PLLEPPSCGESAGGV--AVAGAHFLKQLGTCQ----RLEHLKREKLKTV B3DGN8_DANRE B3DGN8_DANRE -----------PIVDSTVS----TGI----LGLYLRKNAGPAH----RLAHLKQEKLKSV Q5BN24_DANRE Q5BN24_DANRE -----------PIVDSTVS----TGI----LGLHLRKNAGPAH----RLTHLKQEKLKSV B0S6T1_DANRE B0S6T1_DANRE -----------PVVDSTGS----PGTS-AGVGLQLRKNRAGLL----QLEHIKKEKLKTV Q9YGS4_DANRE Q9YGS4_DANRE -----------PVVDSTGS----PGTS-AGVGLQLRKNRAGLL----QLEHIKKEKLKTV Q98SN1_DANRE Q98SN1_DANRE -----------PVVDSTGS----PGTS-AGVGLQLRKNRAGLL----QLEHIKKEKLKTV Q4RK76_TETNG Q4RK76_TETNG -----------PMVDSTVP----AGGQQAGVGLHLRKAVGHSGTVTIKLENIKKERLKTV GLI4_XENLA GLI4_XENLA ----------SPVVDSTVSSWQRSGR--PATPETQRIHSAETGT---AEE-------REI Q9W6B2_XENLA Q9W6B2_XENLA ----------NPVVDSTVS----SAS--PAVGLQLRKHGGTTVQ---RLEQLKKEKLKTM Q9PSZ4_CHICK Q9PSZ4_CHICK ----------LPVVDSTVS----SGN--LTVSLQLRKHMTTMQ----RLEQLKKEKLKTV GLI2_HUMAN GLI2_HUMAN ----------PPGADTSAL----AAP--SAGGLQLRKHMTTMH----RFEQLKKEKLKSL Q59FV5_HUMAN Q59FV5_HUMAN ----------PPGADTSAL----AAP--SAGGLQLRKHMTTMH----RFEQLKKEKLKSL Q0VGT2_MOUSE Q0VGT2_MOUSE ----------CPGADTSAL----AAP--STGGLQLRKHMSTVH----RFEQLKREKLKSL Q0VGV1_MOUSE Q0VGV1_MOUSE ----------CPGADTSAL----AAP--STGGLQLRKHMSTVH----RFEQLKREKLKSL GLI1_XENLA GLI1_XENLA -----------PSVDSMGT----AGA--SALR---------------KLENLRIDKLNQL Q4SS75_TETNG Q4SS75_TETNG -------------VGGGGG----GGGEPGNVGGTMAMSAQALK----RLENLKIDKLKQI Q800Z9_DANRE Q800Z9_DANRE ------GNAGVSESSATIS----SGG--MCMSVQALK----------RLENLKIDKLKQI MATCH . : CONSENSUS ???????????P??D?????????????????L??R?????????????E??K?E?LK??

B3DK55_DANRE B3DK55_DANRE NGAVPRLGFLPPTPPPKGQ--AMPALTGKGQCLG------RSTSVRVP-PCP---EPSNT Q6U6Z9_DANRE Q6U6Z9_DANRE NGAVPRLGFLPPTPPRKGQ--AMPALTGKGQCLG------RMTSVRVP-PCP---EPSNT Q4S1H8_TETNG Q4S1H8_TETNG NEALPRLGPLSPTPPPKVS--TLPTILGKGSCLGRQ----WGVTAPQP-PAH--GELGST GLI3_XENLA GLI3_XENLA NGMLPRL---NPVPPHRAP--TLPPITGNGVQLNSNIS--LGGLAPVL-PNR--NDLSSM Q9I8Q1_COTCO Q9I8Q1_COTCO NGMLPRL---NPVPPSKAP--TLPPLIGNGTKSNSSCN--VGGSMTIL-PNR--NELSST Q9DF31_CHICK Q9DF31_CHICK NGMLPRL---NPVPPSKAP--TLPPLIGNGTQSNSSCS--VGGS---------------- Q9IA31_CHICK Q9IA31_CHICK NGMLPRL---NPVPPSKAP--TLPPLIGNGTQSNSSCS--VGGSMTIL-PNR--NELSST B2RUG4_MOUSE B2RUG4_MOUSE NGMFPRL---NPILPSKAP--AVSPLIGNGTQSNNNYS--SGGPGTLL-PSR--SDLSGV GLI3_MOUSE GLI3_MOUSE NGMFPRL---NPILPSKAP--AVSPLIGNGTQSNNNYS--SGGPGTLL-PSR--SDLSGV B7ZNV2_MOUSE B7ZNV2_MOUSE NGMFPRL---NPILPSKAP--AVSPLIGNGTQSNNNYS--SGGPGTLL-PSR--SDLSGV Q5ISB1_9PRIM Q5ISB1_9PRIM NGMFPRL---NPILPPKAP--AVSPLIGNGTQSNNTCS--LGGPMTLL-PGR--SDLSGV GLI3_PANTR GLI3_PANTR NGMFPRL---NPILPPKAP--AVSPLIGNGTQSNNTCS--LGGPMTLL-PGR--SDLSGV B4DRK1_HUMAN B4DRK1_HUMAN NGMFPRL---NPILPPKAP--AVSPLIGNGTQSNNTCS--LGGPMTLL-PGR--SDLSGV GLI3_HUMAN GLI3_HUMAN NGMFPRL---NPILPPKAP--AVSPLIGNGTQSNNTCS--LGGPMTLL-PGR--SDLSGV Q4SES2_TETNG Q4SES2_TETNG GDSYCWSG--EPAPPVLGT--KLPPVAAPGSLLEE-----THGPAPVPFPAPCLFDLSG- B3DGN8_DANRE B3DGN8_DANRE RDSCSWA---NTAPPAPCT--KLPPINT-GSLLDG-----LCDPGLSI-SSPRLGDLCPG Q5BN24_DANRE Q5BN24_DANRE RDSCSWA---NTAPPAPCT--KLPPI-NTGSLLDG-----LCDPGLSI-SSPRLGDLCPG B0S6T1_DANRE B0S6T1_DANRE RDSCSWA---NAPPQVRNT--KLPPIPSIDSLLDAPN---IGTQMSVP-PTQHLGDLSSY Q9YGS4_DANRE Q9YGS4_DANRE RDSCSWA---NAPPQVRNT--KLPPIPSIDSLLDAPN---MGTQMSVP-PTQHLGDLSSY Q98SN1_DANRE Q98SN1_DANRE RDSCSWA---NAPPQVRNT--KLPPIPSIDSLLDAPN---MGTQMSVP-PTQHLGDLSSY Q4RK76_TETNG Q4RK76_TETNG S-TSDWVSSAAQPLQGQRSSVKLPPIPAVGSLLENSTM--MSNSSVCY-PGPRKGDLSSC GLI4_XENLA GLI4_XENLA KDNERFLLIYEPNATCQNT--RLPTISANGFDV-------IGVPSSVL-INPRAIELSMN Q9W6B2_XENLA Q9W6B2_XENLA KESCSFI---NPPPPARNT--RLPTITANGVSA-------IGVPSSVL-FNPRATELPMN Q9PSZ4_CHICK Q9PSZ4_CHICK KDSCSWV---NPAPQGRNT--KLPPISGNGSILEN-----SGGSSRTL-PNPRIMELSVN GLI2_HUMAN GLI2_HUMAN KDSCSWA---GPTPHTRNT--KLPPLPGSGSILENFSGSGGGGPAGLL-PNPRLSELSAS Q59FV5_HUMAN Q59FV5_HUMAN KDSCSWA---GPTPHTRNT--KLPPLPGSGSILENFSGSGGGGPAGLL-PNPRLSELSAS Q0VGT2_MOUSE Q0VGT2_MOUSE KDSCSWA---GPAPHTRNT--KLPPLPVNGSVLENFNNTGGGGPAGLL-PSQRLPELTE- Q0VGV1_MOUSE Q0VGV1_MOUSE KDSCSWA---GPAPHTRNT--KLPPLPVNGSVLENFNNTGGGGPAGLL-PSQRLPELTE- GLI1_XENLA GLI1_XENLA R---------KTPSSGKMV--KLPSIHNSGPQGDMSV---VCGPLGMS-HNQHGIELPA- Q4SS75_TETNG Q4SS75_TETNG C---------RPSPPARCAGSKLPAIPGTGDNMG------MCVPPPLL-SNRRVMELSSH Q800Z9_DANRE Q800Z9_DANRE R---------RPTPPGRNAGNKLPALSATGEMMS------MCAPSPLL-SNRRVMELSAP MATCH :..: . CONSENSUS ?????????????????????????????G??????????????????????????L???

B3DK55_DANRE B3DK55_DANRE E---LTILSL-LHERRDSSGSNTSSAYLSSSRRSSGISPCFSSRCSSQASL----SEYSP Q6U6Z9_DANRE Q6U6Z9_DANRE E---LTILSL-LHERRDSSGSNTSSAYLSSSRRSSGISPCFSSRCSSQASL----SEYSP Q4S1H8_TETNG Q4S1H8_TETNG E---LTVLNL-LRDRRDSSGSATSSAYLSSSRRSSGISPCFSSRRSSQASQNEATMAAVY GLI3_XENLA GLI3_XENLA D---ITVLN--MLNRRDSNTSTISSAYM-SSRRSSGISPCFSSRRSSEASQ----FEG-- Q9I8Q1_COTCO Q9I8Q1_COTCO D---ITVLN--VLNRRDSNTSTISSAYL-SSRRSSGISPCFSSRRSSDASQ----AEG-- Q9DF31_CHICK Q9DF31_CHICK ------------------------------------------------------------ Q9IA31_CHICK Q9IA31_CHICK D---ITVLN--MLNRRDSNTSTISSAYL-SSRRSSGISPCFSSRRSSDASQ----AEG-- B2RUG4_MOUSE B2RUG4_MOUSE D---FTVLN--TLNRRDSNTSTISSAYL-SSRRSSGISPCFSSRRSSEASQ----AEG-- GLI3_MOUSE GLI3_MOUSE D---FTVLN--TLNRRDSNTSTISSAYL-SSRRSSGISPCFSSRRSSEASQ----AEG-- B7ZNV2_MOUSE B7ZNV2_MOUSE D---FTVLN--TLNRRDSNTSTISSAYL-SSRRSSGISPCFSSRRSSEASQ----AEG-- Q5ISB1_9PRIM Q5ISB1_9PRIM D---VTMLN--MLNRRDSSASTISSAYL-SSRRSSGISPCFSSRRSSEASQ----AEG-- GLI3_PANTR GLI3_PANTR D---VTMLN--MLNRRDSSASTISSAYL-SSRRSSGISPCFSSRRSSEASQ----AEG-- B4DRK1_HUMAN B4DRK1_HUMAN D---VTMLN--MLNRRDSSASTISSAYL-SSRRSSGISPCFSSRRSSEASQ----AEG-- GLI3_HUMAN GLI3_HUMAN D---VTMLN--MLNRRDSSASTISSAYL-SSRRSSGISPCFSSRRSSEASQ----AEG-- Q4SES2_TETNG Q4SES2_TETNG ----TTVLEN-LWERRHSTSSTLSSVYT-LSRRSSGISPCYSSRRSSQASQ----FGA-- B3DGN8_DANRE B3DGN8_DANRE E---TTVLSQ-LVERRDSLASTVSSAYT-FSRRSSGISPCYSSRRSSQTSQ----PGG-- Q5BN24_DANRE Q5BN24_DANRE E---TTVLSQ-LVERRDSLASTVSSAYT-FSRRSSGISPCYSSRRSSQTSQ----PGG-- B0S6T1_DANRE B0S6T1_DANRE E---MTMLNQ-LHERRDSSTSTMSSAYI--SRRSSGISPCYSSRRSSEASQ----FGV-- Q9YGS4_DANRE Q9YGS4_DANRE E---MTMLNQ-LHERRDSSTSTMSSAYI--SRRSSGISPCYSSRRSSEASQ----FGV-- Q98SN1_DANRE Q98SN1_DANRE E---MTMLNQ-LHERRDSSTSTMSSAYI--SRRSSGISPCYSSRRSSEASQ----FGV-- Q4RK76_TETNG Q4RK76_TETNG E---VTLLNQ-LNERRDSTTSTISSAYT-VSRRSSGISPGYSSRRSSEASQ----FGA-- GLI4_XENLA GLI4_XENLA D---VTMMNQ-LNERRDSTSSTLSSAYT--SRRSSGISPYFSSRRSSETSQ----FGG-- Q9W6B2_XENLA Q9W6B2_XENLA D---VTLLNQ-LNERRDSTSSTLSSAYT--SRRSSGISPCFSSRRSSETSQ----FGG-- Q9PSZ4_CHICK Q9PSZ4_CHICK E---VTMLNQ-INERRDSTTSTISSAYT-VSRRSSGISPYFSSRRSSEASQ----LGH-- GLI2_HUMAN GLI2_HUMAN E---VTMLSQ-LQERRDSSTSTVSSAYT-VSRRSSGISPYFSSRRSSEASP----LGA-- Q59FV5_HUMAN Q59FV5_HUMAN E---VTMLSQ-LQERRDSSTSTVSSAYT-VSRRSSGISPYFSSRRSSEASP----LGA-- Q0VGT2_MOUSE Q0VGT2_MOUSE ----VTMLSQ-LQERRDSSTSTMSSAYT-VSRRSSGISPYFSSRRSSEASP----LGG-- Q0VGV1_MOUSE Q0VGV1_MOUSE ----VTMLSQ-LQERRDSSTSTMSSAYT-VSRRSSGISPYFSSRRSSEASP----LGG-- GLI1_XENLA GLI1_XENLA ----SSHVNH-LNDRRNSTTSTMSSAYT-VSRRSSVVSPYLPNQRAGDSGN----M---- Q4SS75_TETNG Q4SS75_TETNG ELGGSASVGC-SNDRRGSGTSSLSSAYT-VSRRSSMVSPYLSSRRSSEVSQ----MGGTA Q800Z9_DANRE Q800Z9_DANRE DMGGVTGMSCPPNDRRGSGTSSLSSAYT-VSRRSSMVSPYLSSRRSSDVSH----CQS-- MATCH CONSENSUS ?????T?L??????RRDS??ST?SSAY???SRRSSGISP??SSRRSS??S??????????

B3DK55_DANRE B3DK55_DANRE HRHIHNLSATDSYDPISTDASRRSSEASQYDGGSSSAVVFGGSGVFKGSGMGS----RGD Q6U6Z9_DANRE Q6U6Z9_DANRE HRHIHNLSATDSYDPISTDASRRSSEASQYDGGSSSAVVFGGSGVFKGSGMGS----RGD Q4S1H8_TETNG Q4S1H8_TETNG HRRLHNLSSTDSYDPISTDASRRSSEASHCGGGGGGMLSAGGCGGAFGLGVGGGGGSRGM GLI3_XENLA GLI3_XENLA --RVQNLSVAGSYDPISTDASRRSSETSQCD--------------------GL----PTL Q9I8Q1_COTCO Q9I8Q1_COTCO --RPQNVSVADSYDPISTDASRRSSEASQCD--------------------DL----PSL Q9DF31_CHICK Q9DF31_CHICK ------------------------------------------------------------ Q9IA31_CHICK Q9IA31_CHICK --RPQNVSVADSYDPISTDASRRSSEASQCD--------------------DL----PSL B2RUG4_MOUSE B2RUG4_MOUSE --RPQNVSVADSYDPISTDASRRSSEASQGD--------------------GL----PSL GLI3_MOUSE GLI3_MOUSE --RPQNVSVADSYDPISTDASRRSSEASQGD--------------------GL----PSL B7ZNV2_MOUSE B7ZNV2_MOUSE --RPQNVSVADSYDPISTDASRRSSEASQGD--------------------GL----PSL Q5ISB1_9PRIM Q5ISB1_9PRIM --RPQNVSVADSYDPISTDASRRSSEASQGD--------------------GL----PSL GLI3_PANTR GLI3_PANTR --RPQNVSVADSYDPISTDASRRSSEASQSD--------------------GL----PSL B4DRK1_HUMAN B4DRK1_HUMAN --RPQNVSVADSYDPISTDASRRSSEASQSD--------------------GL----PSL GLI3_HUMAN GLI3_HUMAN --RPQNVSVADSYDPISTDASRRSSEASQSD--------------------GL----PSL Q4SES2_TETNG Q4SES2_TETNG -NRPNNLSSADSYDPISADISRRSSQVSQFGESGGGTEGYA----------GL----ASP B3DGN8_DANRE B3DGN8_DANRE --RHNNISSADSYDPISTDLSRRSSEASLYG---------------------------GI Q5BN24_DANRE Q5BN24_DANRE --RHNNISSADSYDPISTDLSRRSSEASLYG---------------------------GI B0S6T1_DANRE B0S6T1_DANRE --RNNNVSSADSYDPISTDLSRRSSEASQCGGTG-----------------GL----PSL Q9YGS4_DANRE Q9YGS4_DANRE --RNNNVSSADSYDPISTDLSRRSSEASQCGGTG-----------------GL----PSL Q98SN1_DANRE Q98SN1_DANRE --RNNNVSSADSYDPISTDLSRRSSEASQCGGTG-----------------GL----PSL Q4RK76_TETNG Q4RK76_TETNG -NRHNNVSSADSYDPISTDLSRRSSEASQCGVG------------------GG----ATL GLI4_XENLA GLI4_XENLA --RLNNSSSADSYDPISTDASRRSSEASQHS--------------------GL----PNL Q9W6B2_XENLA Q9W6B2_XENLA --RLNNSSSADSYDPISTDASRRSSEASHHS--------------------GL----PNL Q9PSZ4_CHICK Q9PSZ4_CHICK --RPNNTSSADSYDPIS------------------------------------------- GLI2_HUMAN GLI2_HUMAN -GRPHNASSADSYDPISTDASRRSSEASQCS--------------------GG----SGL Q59FV5_HUMAN Q59FV5_HUMAN -GRPHNASSADSYDPISTDASRRSSEASQCS--------------------GG----SGL Q0VGT2_MOUSE Q0VGT2_MOUSE -LRPHNASSADSYDPISTDASRRSSEASQCSG-------------------GG----PGL Q0VGV1_MOUSE Q0VGV1_MOUSE -LRPHNASSADSYDPISTDASRRSSEASQCSGG------------------G-----PGL GLI1_XENLA GLI1_XENLA ---------VDSYD-ISTDPSGHSNEAVCAS--------------------GL----PG- Q4SS75_TETNG Q4SS75_TETNG GGGCHSFGSEIVADPLSPETNRRGAPCPGG---------------------GL----PGL Q800Z9_DANRE Q800Z9_DANRE -----VMGGEVPGDPLSPQNSQRAGLCQNSG--------------------GL----PGL MATCH CONSENSUS ??R??N?S??DSYDPISTD?SRRSSEAS???????????????????????G????????

B3DK55_DANRE B3DK55_DANRE LNLTPAQHYSLKAKYAAATGGPPPTPLPSMGHINLKT-HF-ALKEDRKDTGQLTLPPLVR Q6U6Z9_DANRE Q6U6Z9_DANRE LNLTPAQHYSLKAKYAAATGGPPPTPLPSMGHINLKT-HF-ALKEDRKDTGQLTLPPLVR Q4S1H8_TETNG Q4S1H8_TETNG LSLTPAQHYHLKAKYAAATGGPPPTPLPNMER----------MMGDALVR---------- GLI3_XENLA GLI3_XENLA LSLTPAQQYRLKAKYAAATGGPPPTPLPNMERMSLKT-RM-ALLGDSRDCRLSPLPSVNV Q9I8Q1_COTCO Q9I8Q1_COTCO LSLTPAQQYRLKAKYAAATGGPPPTPLPNMERMSLKT-RM-ALLGDCRESGVSPLPPVNA Q9DF31_CHICK Q9DF31_CHICK ------------------------------------------------------------ Q9IA31_CHICK Q9IA31_CHICK LSLTPAQQYRLKAKYAAATGGPPPTPLPNMERMSLKT-RM-ALLGDCRESGISPLPPVNA B2RUG4_MOUSE B2RUG4_MOUSE LSLTPVQQYRLKAKYAAATGGPPPTPLPHMERLSLKT-KM-ALLGEGRDSGVTLPPVHP- GLI3_MOUSE GLI3_MOUSE LSLTPVQQYRLKAKYAAATGGPPPTPLPHMERLSLKT-KM-ALLGEGRDSGVTLPPVHP- B7ZNV2_MOUSE B7ZNV2_MOUSE LSLTPVQQYRLKAKYAAATGGPPPTPLPHMERLSLKT-KM-ALLGEGRDSGVTLPPVHP- Q5ISB1_9PRIM Q5ISB1_9PRIM LSLTPAQQYRLKAKYAAATGGPPPTPLPNMERMSLKT-RL-ALLGDSLEPGVALPPVHV- GLI3_PANTR GLI3_PANTR LSLTPAQQYRLKAKYAAATGGPPPTPLPNMERMSLKT-RL-ALLGDALEPGVALPPVHA- B4DRK1_HUMAN B4DRK1_HUMAN LSLTPAQQYRLKAKYAAATGGPPPTPLPNMERMSLKT-RL-ALLGDALEPGVALPPVHA- GLI3_HUMAN GLI3_HUMAN LSLTPAQQYRLKAKYAAATGGPPPTPLPNMERMSLKT-RL-ALLGDALEPGVALPPVHA- Q4SES2_TETNG Q4SES2_TETNG LSLTPAQHYHLKAKYAAATGSPAPSPLPHVDQ------------------GPYTP----- B3DGN8_DANRE B3DGN8_DANRE FSLTPAQHYRLKAKYAAATGGAPPTPLPNIDCKT--------LLGDSHEIPIHPPLV--- Q5BN24_DANRE Q5BN24_DANRE FSLTPAQHYRLKAKYAAATGGAPPTPLPNIDCKT--------LLGDSHEIPIHPPLV--- B0S6T1_DANRE B0S6T1_DANRE LNLTPAQHYSLKAKYAAATGGAPPTPLPNMDRMSLKT-RM-AMYNDSQDSSAHLHHAQGV Q9YGS4_DANRE Q9YGS4_DANRE LNLTPAQHYSLKAKYAAATGGAPPTPLPNMDRMSLKT-RM-AMYNDSQDSSAHLHHAQGV Q98SN1_DANRE Q98SN1_DANRE LNLTPAQHYSLKAKYAAATGGAPPTPLPNMDRMSLKT-RM-AMYNDSQDSSAHLHHAQGV Q4RK76_TETNG Q4RK76_TETNG LSLTPAQHYRLKAKYAAATGGAPPTPLPNMDRMSLRT-RM-ALYSDSQEASLHQFHQPPT GLI4_XENLA GLI4_XENLA LNLTPAQHYRLKAKYAAATGGPPPTPLPNMDRIGLRN-KL-SLM-DGADFPLPPFRQLPV Q9W6B2_XENLA Q9W6B2_XENLA LNLTPAQQYRLKAKYAAATGGPPPTPLANMDRINLRN-KL-SLM-DRPDFPLHAFRQLPV Q9PSZ4_CHICK Q9PSZ4_CHICK ------------------TGGR-------------------------------------- GLI2_HUMAN GLI2_HUMAN LNLTPAQQYSLRAKYAAATGGPPPTPLPGLERMSLRT-RL-ALL-DAPERTLPAGCPRPL Q59FV5_HUMAN Q59FV5_HUMAN LNLTPAQQYSLRAKYAAATGGPPPTPLPGLERMSLRT-RL-ALL-DAPERTLPAGCPRPL Q0VGT2_MOUSE Q0VGT2_MOUSE LNLTPAQQYNLRAKYAAATGGPPPTPLPGLDRVSLRT-RL-ALL-DAPERALPGACPHPL Q0VGV1_MOUSE Q0VGV1_MOUSE LNLTPAQQYNLRAKYAAATGGPPPTPLPGLDRVSLRT-RL-ALL-DAPERALPGACPHPL GLI1_XENLA GLI1_XENLA --LTPAQQYRLKAKYAAATGGPPPTPLPNMERMNTNN-RMAFASSDYRGSAISSL----- Q4SS75_TETNG Q4SS75_TETNG SNLTPAQQYNLKAKYAAATGGPPPTPLPNMEQMGATTARRGGYLSEYQGQPLPPFLTQGG Q800Z9_DANRE Q800Z9_DANRE PSLTPAQQYSLKAKYAAATGGPPPTPLPNMDQAGTPA-RHVGFLRECQGQPLPPFLQQGG MATCH CONSENSUS ??LTPAQ?Y?LKAKYAAATGG?PPTPLP????????????????????????????????

B3DK55_DANRE B3DK55_DANRE ---SRRCSDG---AHNSHDSQAVYQRKGTYFGGGPGKNDRRASDPTHHKQNLSSYGLPQV Q6U6Z9_DANRE Q6U6Z9_DANRE ---SRRCSDG---AHNSHDSQAVYQRKGTYFGGGPGKNDRRASDPTHHKQNLSSYGLPQV Q4S1H8_TETNG Q4S1H8_TETNG ---PHRCADGSPGSVNGHTGHSGYRRRVLYPGEGSANRNRRASDPVRSQ-APDACSLPPV GLI3_XENLA GLI3_XENLA ---PRRCSDG---------GVGSYGRRHLLPNELQVNGMRRASDPVKM--VSDNVSNTRV Q9I8Q1_COTCO Q9I8Q1_COTCO ---PRRSSDG---------GANGYSRRHLLSHDALGNGTRRASDPVRM--VSDSQSVPRV Q9DF31_CHICK Q9DF31_CHICK ------------------------------------------------------------ Q9IA31_CHICK Q9IA31_CHICK ---PRRCSDG---------GANGYSRRHLLSHDALGNGTRRASDPVRM--VSNNLSVPRV B2RUG4_MOUSE B2RUG4_MOUSE ---PRRCSDG---------GGHTYRGRHLMPHDALANSVRRASDPVRT--VSENMSLARV GLI3_MOUSE GLI3_MOUSE ---PRRCSDG---------GGHTYRGRHLMPHDALANSVRRASDPVRT--VSENMSLARV B7ZNV2_MOUSE B7ZNV2_MOUSE ---PRRCSDG---------GGHTYRGRHLMPHDALANSVRRASDPVRT--VSENMSLARV Q5ISB1_9PRIM Q5ISB1_9PRIM ---PRRCSDG-------------------------------------------------- GLI3_PANTR GLI3_PANTR ---PRRCSDG---------GAHGYGRRHLQPHDAPGHGVRRASDPVRT--GSEGLALPRV B4DRK1_HUMAN B4DRK1_HUMAN ---PRRCSDG---------GAHGYGRRHLQPHDALGHGVRRASDPVRT--GSEGLALPRV GLI3_HUMAN GLI3_HUMAN ---PRRCSDG---------GAHGYGRRHLQPHDALGHGVRRASDPVRT--GSEGLALPRV Q4SES2_TETNG Q4SES2_TETNG ---WSQCAQE-------------FAARGLMPHEVSAHTARRASDPVRPL-GGAPAHQPQM B3DGN8_DANRE B3DGN8_DANRE ---PRRCSDT------------GYANRSVLPHEVTANITRRASDPVRRIAAEQHSLYNSV Q5BN24_DANRE Q5BN24_DANRE ---PRRCSDT------------GYANRSVLPHEVTANITRRASDPVRRIAAERHSLYNSV B0S6T1_DANRE B0S6T1_DANRE VN-SRRCSDT------------GYGAPGIMPHEVPANLPRRASDPVRRT-TLDPLSLPRV Q9YGS4_DANRE Q9YGS4_DANRE VN-SRRCSDT------------GYGAPGMMPHEVPANLPRRASDPVRRT-TLDPLSLPRV Q98SN1_DANRE Q98SN1_DANRE VN-SRRCSDT------------GYGAPGMMPHEVPANLPRRASDPVRRT-TLDPLSLPRV Q4RK76_TETNG Q4RK76_TETNG GAVPRRCSDM------------GYGTRSMMPHEVPSSLPRRASDPVRRP-PLDPLSLPRV GLI4_XENLA GLI4_XENLA ---PRRCSDG----------GGNAGLTPMYPHEIPGNNSRRASDPVRRTAGIDDKPLPRF Q9W6B2_XENLA Q9W6B2_XENLA ---PRRCSDG-----------GGNAGLAVYPHEIPGNNSRRASDPVRRTGGMDGQGLPRV Q9PSZ4_CHICK Q9PSZ4_CHICK ------------------------------------------------------------ GLI2_HUMAN GLI2_HUMAN G--PRRGSDG------PTYGHGHAGAAPAFPHEAPGGGARRASDPVRRP---DALSLPRV Q59FV5_HUMAN Q59FV5_HUMAN G--PRRGSDG------PTYGHGHAGAAPAFPHEAPGGGARRASDPVRRP---DALSLPRV Q0VGT2_MOUSE Q0VGT2_MOUSE G--PRRGSDGP--TYSHGHGHGYAGAAPAFPHEGPNSSTRRASDPVRRP---DPLILPRV Q0VGV1_MOUSE Q0VGV1_MOUSE G--PRRGSDGP--TYSHGHGHGYAGAAPAFPHEGPNSSTRRASDPVRRP---DPLILPRV GLI1_XENLA GLI1_XENLA ---QRRHSSN---------EYHNYGTGIIHPAQAPGAGIRRASDPART--GGDIQAVPKV Q4SS75_TETNG Q4SS75_TETNG ---PRRHSAN-----------TEYGTGVIYPHQAPGNNTRRASDPLSP------------ Q800Z9_DANRE Q800Z9_DANRE ---TRRHSAN-----------AEYGTGVIYPHQAPGNNTRRASDPVRS--AADPQGLPKV MATCH CONSENSUS ????RR?SD??????????????????????????????RRASDP??????????????V

B3DK55_DANRE B3DK55_DANRE RHFSSLNNMTSSPNPASYGYSNREDHSLNLQNSTCHVDSFQSGL-HSPCPPSIMEQSALE Q6U6Z9_DANRE Q6U6Z9_DANRE RHFSSLNNMTSSPNPASYGYSNREDHSLNLQNSTCHVDSFQSGL-HSPCPPSIMEQSALE Q4S1H8_TETNG Q4S1H8_TETNG QRFSSLNNLHP--LPPLSHHSIPENCSLSLQNSARSEGNMQRILQHSAYNPSIAEHAALE GLI3_XENLA GLI3_XENLA VRFNSLNNVIPPDVPPPM-----ERRNLSLQNYTRNV--------YSPCPPSISENVALE Q9I8Q1_COTCO Q9I8Q1_COTCO QHFNSLNSFNSPALPPSM-----EKRNRVLQNCTRSEGGLFRGF-SSPCPPSISENVTLE Q9DF31_CHICK Q9DF31_CHICK ------------------------------------------------------------ Q9IA31_CHICK Q9IA31_CHICK QHFNSLNSFNSPALPPSM-----EKRNLVLQNCTHSEGGVFRGF-SSPCPPSISENVTLE B2RUG4_MOUSE B2RUG4_MOUSE QRFSSLNSFNPPNLPPSV-----EKRSLVLQNYTRQESSQPRYFQASPCPPSITENVALE GLI3_MOUSE GLI3_MOUSE QRFSSLNSFNPPNLPPSV-----EKRSLVLQNYTRQESSQPRYFQASPCPPSITENVALE B7ZNV2_MOUSE B7ZNV2_MOUSE QRFSSLNSFNPPNLPPSV-----EKRSLVLQNYTRQESSQPRYFQASPCPPSITENVALE Q5ISB1_9PRIM Q5ISB1_9PRIM ------------------------------------------------------------ GLI3_PANTR GLI3_PANTR PRFSSLSSCNPPAMATSA-----EKRSLVLQNYTRPEGGQSRNFHSSPCPPSITENVTLE B4DRK1_HUMAN B4DRK1_HUMAN PRFSSLSSCNPPAMATSA-----EKRSLVLQNYTRPEGGQSRNFHSSPCPPSITENVTLE GLI3_HUMAN GLI3_HUMAN PRFSSLSSCNPPAMATSA-----EKRSLVLQNYTRPEGGQSRNFHSSPCPPSITENVTLE Q4SES2_TETNG Q4SES2_TETNG QRYNSLGTL--------------------------------------------------- B3DGN8_DANRE B3DGN8_DANRE NPYPTLHPLASSR-----------------HFYSMSESNVNRQQ-YPPRAPSISENVMME Q5BN24_DANRE Q5BN24_DANRE NPYPTLHPLASSR-----------------HFYSTSESNVNRQQ-YPPRAPSISENVMME B0S6T1_DANRE B0S6T1_DANRE QRFNSISNMNLSRLPAY------DRRAFNMQNNTWSDGSLHRHP-FSQRPPSISENILME Q9YGS4_DANRE Q9YGS4_DANRE QRFNSISNMNLSRLPAY------DRRAFNMQNNTWSDGSLHRHP-FSQRPPSISENILME Q98SN1_DANRE Q98SN1_DANRE QRFNSISNMNLSRLPAY------DRRAFNMQNNTWSDGSLHRHP-FSQRPPSISENILME Q4RK76_TETNG Q4RK76_TETNG QRYNSMNNMNPLNVTTAE-----RYQSLLAQGYTRSDGNLQRYP-FAPRPPSISENVAME GLI4_XENLA GLI4_XENLA SRFHSMNSMNTLHPPSLS-----ERRNGGLQHYTCSDGGLHRHV-YSPRPPSISENVAME Q9W6B2_XENLA Q9W6B2_XENLA QRFHSMNSMNTLHHPSLS-----ERRNGGLQHYNRSDGSLHRHV-YSPRPPSINENVAME Q9PSZ4_CHICK Q9PSZ4_CHICK ------------------------------------------------------------ GLI2_HUMAN GLI2_HUMAN QRFHSTHNVNPGPLPPCA-----DRRGLRLQSHPSTDGGLARGA-YSPRPPSISENVAME Q59FV5_HUMAN Q59FV5_HUMAN QRFHSTHNVNPGPLPPCA-----DRRGLRLQSHPSTDGGLARGA-YSPRPPSISENVAME Q0VGT2_MOUSE Q0VGT2_MOUSE QRFHSTHNMNPGSLPPCA-----DRRGLHVQSHPSVDSNLTRNA-YSPRPPSINENVVME Q0VGV1_MOUSE Q0VGV1_MOUSE QRFHSTHNMNPGSLPPCA-----DRRGLHVQSHPSVDSNLTRNA-YSPRPPSINENVVME GLI1_XENLA GLI1_XENLA QRFKSMTNMNVSMMG--------RQGTSIQQAYGGSDANLQRHM-FSPRPPSITENVFME Q4SS75_TETNG Q4SS75_TETNG ------------------------------------------------------------ Q800Z9_DANRE Q800Z9_DANRE QRFNSLSNVSLM-----------SRRNALQQ--CGSDAALSRHM-YSPRPPSITENVMME MATCH CONSENSUS ????S?????????????????????????????????????????????PSI?E????E

B3DK55_DANRE B3DK55_DANRE NIFMNQDGLL-------LRVNENIQSDFMQYLHSQDQ----------------ESIIIQD Q6U6Z9_DANRE Q6U6Z9_DANRE NIFMNQDGLL-------LRVNENIQSDFMQYLHSQDQ----------------ESIIIQD Q4S1H8_TETNG Q4S1H8_TETNG ALAMEEDGGAGLL----LGDEDMLPDDLVQYLHSQVQSDSCAFMNV-------EEQLASS GLI3_XENLA GLI3_XENLA AMIMEAEGN--------FDDEDLLPDDMVQYLNSRNQRLYETI----------ETDALQN Q9I8Q1_COTCO Q9I8Q1_COTCO AAVMEAGGS--------LNDEDLLPDDVVQYLNSQNQGMYDHLLNNVL-----DSNKMQH Q9DF31_CHICK Q9DF31_CHICK ------------------------------------------------------------ Q9IA31_CHICK Q9IA31_CHICK AVTMEAGGS--------LNDEDLLPDDVVQYLNSQNQGTCDHLLNNVL-----DSNKMHH B2RUG4_MOUSE B2RUG4_MOUSE ALTMDADAN--------LNDEDLLPDDVVQYLNSQNQTG--------------YGQQLQS GLI3_MOUSE GLI3_MOUSE ALTMDADAN--------LNDEDLLPDDVVQYLNSQNQTG--------------YGQQLQS B7ZNV2_MOUSE B7ZNV2_MOUSE ALTMDADAN--------LNDEELLPDDVVQYLNSQNQTG--------------YGQQLQS Q5ISB1_9PRIM Q5ISB1_9PRIM ------------------------------------------------------------ GLI3_PANTR GLI3_PANTR SLTMDADAN--------LNDEDFLPDDVVQYLNSQNQAG--------------YEQHFPS B4DRK1_HUMAN B4DRK1_HUMAN SLTMDADAN--------LNDEDFLPDDVVQYLNSQNQAG--------------YEQHFPS GLI3_HUMAN GLI3_HUMAN SLTMDADAN--------LNDEDFLPDDVVQYLNSQNQAG--------------YEQHFPS Q4SES2_TETNG Q4SES2_TETNG ------------------------------------------------------------ B3DGN8_DANRE B3DGN8_DANRE TLPDDMESCNG------VEDGLMMADDAVQCITTQNADSPQHTGVVH------RNQSFGS Q5BN24_DANRE Q5BN24_DANRE TLPDDMESCNG------VEDGLMMADDAVQCITTQNADSPQHTGVAH------RNQSFGS B0S6T1_DANRE B0S6T1_DANRE NMATDGGDQ--------QGDDLVLPDDMVQYLRSQNGNSNHDSGISVNGG---HALEFHG Q9YGS4_DANRE Q9YGS4_DANRE NMATDGGDQ--------QGDDLVLPDDMVQYLRSQNGNSNHDSGISVNGG---HALEFHG Q98SN1_DANRE Q98SN1_DANRE NMATDGGDQ--------QGDDLVLPDDMVQYLRSQNGNSNHDSGISVNGG---HALEFHG Q4RK76_TETNG Q4RK76_TETNG NMAMDGMAGGDQN----GEDDMVLPDDMVQYLRSQNTDPSANNSCQVDYHSNHQNQGFQA GLI4_XENLA GLI4_XENLA AISCDADVPG-------GDDDLMLPDDVVQYIRSQNREAPEQNLQTEYSS---PARNLQS Q9W6B2_XENLA Q9W6B2_XENLA AISCDLDVPG-------GDDDLMLPDDVVQYIRSQNREAPKQNLPIEYNS---PARNLQS Q9PSZ4_CHICK Q9PSZ4_CHICK ------------------------------------------------------------ GLI2_HUMAN GLI2_HUMAN AVAAGVDGAGPEADLGLPEDDLVLPDDVVQYIKAHASGALDEGTGQVYPT---ESTGFSD Q59FV5_HUMAN Q59FV5_HUMAN AVAAGVDGAGPEADLGLPEDDLVLPDDVVQYIKAHASGALDEGTGQVYPT---ESTGFSD Q0VGT2_MOUSE Q0VGT2_MOUSE AVAAGVDGPGLECDLGLVEDELVLPDDVVQYIKAHTGGTLDDGIRQGYPT---EGTGFPE Q0VGV1_MOUSE Q0VGV1_MOUSE AVAAGVDGPGLECDLGLVEDELVLPDDVVQYIKAHTGGTLDDGIRQGYPT---EGTGFPE GLI1_XENLA GLI1_XENLA TAGPDEVCHT-------KEQGFIQSNEMQHYMNYQGQGSQLTAPNDHMN----FNPQIHG Q4SS75_TETNG Q4SS75_TETNG -----------------GHDSLRCPDQAYMHGRYQNPGGDVSSKAGNSTG---QARPFQS Q800Z9_DANRE Q800Z9_DANRE AMGMDGNTEG-------RQQGNMIPGGDRSYMGYQHNPHQASQLSPGQESLGCIDQVYQS MATCH CONSENSUS ????????????????????????????????????????????????????????????

B3DK55_DANRE B3DK55_DANRE NHRPIFN---------------------------PADDQNFLSPQQQQ----EGVEQEDT Q6U6Z9_DANRE Q6U6Z9_DANRE NHRPIFN---------------------------PADDQNFLSPQQQQ----EGVEQEDT Q4S1H8_TETNG Q4S1H8_TETNG QRDPSYP-----------------SMEELEQIQSSGLDMSYSGSHGLQQQIAERRSPS-- GLI3_XENLA GLI3_XENLA NAGERNG-----------------NNFEQSHV--------TSNVINEQFHSSEQTDLIEN Q9I8Q1_COTCO Q9I8Q1_COTCO SVVLGNN-----------------N---------------PSSFDRAPPASSQPAGSEAS Q9DF31_CHICK Q9DF31_CHICK ------------------------------------------------------------ Q9IA31_CHICK Q9IA31_CHICK SVVLGNN--------------------------------NPSSFDRAPPASSQPAGSEVS B2RUG4_MOUSE B2RUG4_MOUSE GISEDSK-----------------VAHEPEDLDLAGLPDSHVGQEYPAL---EQPCSEGS GLI3_MOUSE GLI3_MOUSE GISEDSK-----------------VAHEPEDLDLAGLPDSHVGQEYPAL---EQPCSEGS B7ZNV2_MOUSE B7ZNV2_MOUSE GISEDSK-----------------VAHEPEDLDLAGLPDSHVGQEYPAL---EQPCSEGS Q5ISB1_9PRIM Q5ISB1_9PRIM ------------------------------------------------------------ GLI3_PANTR GLI3_PANTR TLPDDSK-----------------VPHGPGDFDAPGLPDSHAGQQFHAL---EQPCPEGS B4DRK1_HUMAN B4DRK1_HUMAN ALPDDSK-----------------VPHGPGDFDAPGLPDSHAGQQFHAL---EQPCPEGS GLI3_HUMAN GLI3_HUMAN ALPDDSK-----------------VPHGPGDFDAPGLPDSHAGQQFHAL---EQPCPEGS Q4SES2_TETNG Q4SES2_TETNG ------------------------------------------------------------ B3DGN8_DANRE B3DGN8_DANRE PQH----------------------CHLQRRLALVEGNMNAVARQTASSQQTFPGSANAT Q5BN24_DANRE Q5BN24_DANRE PQ----------------------HCHLQRRLALVEGNMNAVARQTASSQQTFPGSANAT B0S6T1_DANRE B0S6T1_DANRE NMTSQQQ-----------------QFYGQRRMGMASINGSHVEPVPEQ----IADPQGMN Q9YGS4_DANRE Q9YGS4_DANRE NMTSQQQ-----------------QFYGQRRMGMAGINGSHVEPVPEQ----IADPQGMN Q98SN1_DANRE Q98SN1_DANRE NMTSQQQ-----------------QFYGQRRMGMAGINGSHVEPVPEQ----IADPQGMN Q4RK76_TETNG Q4RK76_TETNG GIAPPPA------------------YYSQRRMAMVDASMPHSGQDSQQ--PFSAPPANTN GLI4_XENLA GLI4_XENLA NTKSFHN-----------------NTPEQPRA--PGA---YLSRNFPALAECLGQTANMQ Q9W6B2_XENLA Q9W6B2_XENLA SIKPFHH-----------------N--TPHRA--PGA---YSSRNFPALAECLDQTANMQ Q9PSZ4_CHICK Q9PSZ4_CHICK ------------------------------------------------------------ GLI2_HUMAN GLI2_HUMAN NPRLPSP-----------------GLHGQRRMVAADSNVGPSAPMLGGCQLGFGAPSSLN Q59FV5_HUMAN Q59FV5_HUMAN NPRLPSP-----------------GLHGQRRMVAADSNVGPSAPMLGGCQLGFGAPSSLN Q0VGT2_MOUSE Q0VGT2_MOUSE NSKLPSP-----------------GLQGHRRLAAADSNMGPSAPGLGGCQLSYSPSSNLN Q0VGV1_MOUSE Q0VGV1_MOUSE NSKLPSP-----------------GLQGHRRLAAADSNMGPSAPGLGGCQLSYSPSSNLN GLI1_XENLA GLI1_XENLA -LDGQSQ-----------------NVYSHSQRAISNMHLNAENYSGQSNVSNFNQCQMTA Q4SS75_TETNG Q4SS75_TETNG EGMSN-------------------SLLQQTEYSMSTCQLSPSAPHYPSIGQGGDAGGRWS Q800Z9_DANRE Q800Z9_DANRE QMQGQYQREESCSTGVMGQADIANNLLQQAEYGMSTCQLSPSGPHYPSQGDGSGPWGQTN MATCH CONSENSUS ????????????????????????????????????????????????????????????

B3DK55_DANRE B3DK55_DANRE RI-------------DLMPIQSNEVSSASADVT--IPRQP------------FQRCGRWS Q6U6Z9_DANRE Q6U6Z9_DANRE RI-------------DLMPIQSNEVSSASADVT--IPRQP------------FQRCGRWS Q4S1H8_TETNG Q4S1H8_TETNG ---------------SL-PIQWNEVSSGSADRS--------------------------- GLI3_XENLA GLI3_XENLA KN-------------DL-PIQWNEVSSGSAEYSPSRLKYG------------QRF----- Q9I8Q1_COTCO Q9I8Q1_COTCO KS-------------DL-PIQWNEVSSGSSELSPTKLKCS------------QRS----- Q9DF31_CHICK Q9DF31_CHICK ------------------------------------------------------------ Q9IA31_CHICK Q9IA31_CHICK KS-------------DL-PIQWNEVSSGSSDLSPTKLKCS------------QRS----- B2RUG4_MOUSE B2RUG4_MOUSE KT-------------DL-PIQWNEVSSGTSDLSSSKLKCG------------QQR----- GLI3_MOUSE GLI3_MOUSE KT-------------DL-PIQWNEVSSGTSDLSSSKLKCG------------QQR----- B7ZNV2_MOUSE B7ZNV2_MOUSE KT-------------DL-PIQWNEVSSGTSDLSSSKLKCG------------QQR----- Q5ISB1_9PRIM Q5ISB1_9PRIM ---------------------------GA------------------------------- GLI3_PANTR GLI3_PANTR KT-------------DL-PIQWNEVSSGSADLSSSKLKCG------------PRP----- B4DRK1_HUMAN B4DRK1_HUMAN KT-------------DL-PIQWNEVSSGSADLSSSKLKCG------------PRP----- GLI3_HUMAN GLI3_HUMAN KT-------------DL-PIQWNEVSSGSADLSSSKLKCG------------PRP----- Q4SES2_TETNG Q4SES2_TETNG ------------------------------------------------------------ B3DGN8_DANRE B3DGN8_DANRE KI-------------PM-PVQWNEVSSGTVDSSRSQTKQG------------SGR----- Q5BN24_DANRE Q5BN24_DANRE KI-------------PM-PVQWNEVSSGTVDSSRSQTKQG------------SGR----- B0S6T1_DANRE B0S6T1_DANRE KN-------------NM-PVQWNEVSSGSADAVSRVPKQQ------------QQQ-LRGN Q9YGS4_DANRE Q9YGS4_DANRE KN-------------NM-PVQWNEVSSGSADAVSRVPKQ-------------QQQQLRGN Q98SN1_DANRE Q98SN1_DANRE KN-------------NM-PVQWNEVSSGSADAVSRVPKQ-------------QQQQLRGN Q4RK76_TETNG Q4RK76_TETNG KN-------------NM-PVQWNEVSSGTVDSTSKLSKQQ------------HHP-LRGN GLI4_XENLA GLI4_XENLA DN-------------NM-PVQWNEVSSGTVDVS-DLPKQQ------------FAA---GN Q9W6B2_XENLA Q9W6B2_XENLA DN-------------SM-PVQWNEVSSGTVDVS-DLPKQP------------FGP---GN Q9PSZ4_CHICK Q9PSZ4_CHICK ------------------------------------------------------------ GLI2_HUMAN GLI2_HUMAN KN-------------NM-PVQWNEVSSGTVDALASQVKPP------------PFP--QGN Q59FV5_HUMAN Q59FV5_HUMAN KN-------------NM-PVQWNEVSSGTVDALASQVKPP--------------PFPQGN Q0VGT2_MOUSE Q0VGT2_MOUSE KS-------------NM-PVQWNEVSSGTVDALPTQVKPP------------PFP--HSN Q0VGV1_MOUSE Q0VGV1_MOUSE KS-------------NM-PVQWNEVSSGTVDALPTQVKPP------------PFP--HSN GLI1_XENLA GLI1_XENLA HNQHFQNTRQAYNCANL-PVQWNEVSSGTMDNPVQRPNHQIMHQNMSPGNHCQSQLSNCT Q4SS75_TETNG Q4SS75_TETNG DN---------------------------------------------------------- Q800Z9_DANRE Q800Z9_DANRE QL-------------HSPGMQYQGAGMQGQHYTQQGIYDP--------------TSNPNL MATCH CONSENSUS ??????????????????P?Q?NEVSS?????????????????????????????????

B3DK55_DANRE B3DK55_DANRE DQSGSVSNAF----GRFGNMVVQQQPIDFIDQHSALQ----------------------- Q6U6Z9_DANRE Q6U6Z9_DANRE DQSGSVSNAF----GRFGNMVVQQQPIDFIDQHSALQ----------------------- Q4S1H8_TETNG Q4S1H8_TETNG ------------------------------------------------------------ GLI3_XENLA GLI3_XENLA --PTQQNQPF----GLYNNMMVQQQNVPKSGLSQQRGYQHHTQNNP-------QAPQQNL Q9I8Q1_COTCO Q9I8Q1_COTCO --AGQQARAF----ELYNNMMVQQQNLQRSNVPQQNGYQSLMENSGSYILQQNTGLG--- Q9DF31_CHICK Q9DF31_CHICK ------------------------------------------------------------ Q9IA31_CHICK Q9IA31_CHICK --AVQQARAF----GLYNNMMVQQQNLQRGNVYQQNGYQNLMENNGSYSLQQNTVLG--- B2RUG4_MOUSE B2RUG4_MOUSE -PSAQQPRGF----GLYNNMVVHPHNLWKVGTGPAGGYQTLGENSSTYNGPEHFAIHSGD GLI3_MOUSE GLI3_MOUSE -PSAQQPRGF----GLYNNMVVHPHNLWKVGTGPAGGYQTLGENSSTYNGPEHFAIHSGD B7ZNV2_MOUSE B7ZNV2_MOUSE -PSAQQPRGF----GLYNNMVVHPHNLWKVGTGPAGGYQTLGENSSTYNGPEHFAIHSGD Q5ISB1_9PRIM Q5ISB1_9PRIM ------------------------------------------------------------ GLI3_PANTR GLI3_PANTR --AVPQTRAF----GFCNGMVVHPQNPLRSG--PAGGYQTLGENSNPYGGPEHLMLHNSP B4DRK1_HUMAN B4DRK1_HUMAN --AVPQTRAF----GFCNGMVVHPQNPLRSG--PAGGYQTLGENSNPYGGPEHLMLHNSP GLI3_HUMAN GLI3_HUMAN --AVPQTRAF----GFCNGMVVHPQNPLRSG--PAGGYQTLGENSNPYGGPEHLMLHNSP Q4SES2_TETNG Q4SES2_TETNG ------------------------------------------------------------ B3DGN8_DANRE B3DGN8_DANRE -GNLQQKQNL----SSFLNVNSNQQVGLMSHNLALSPVQRSVEFNS-------------- Q5BN24_DANRE Q5BN24_DANRE -GNLQQKQNL----SSFLNVNSNQQVGLMSHNLALSPVQRSVEFNS-------------- B0S6T1_DANRE B0S6T1_DANRE LTVVQQKQNF----GSYQGFGSNQQIVPMSQNLASLQQAYPQRNIQ-------------- Q9YGS4_DANRE Q9YGS4_DANRE LTVVQQKQNF----GSYQGFGSNQQIVPMSQNLASLQQAYPQRNIQ-------------- Q98SN1_DANRE Q98SN1_DANRE LTVVQQKQNF----GSYQGFGSNQQIVPMSQNLASLQQAYPQRNIQ-------------- Q4RK76_TETNG Q4RK76_TETNG LAVVQQRHNFSSFQGPSQALSSNQQVVPMSQNVSTQAYAN-------------------- GLI4_XENLA GLI4_XENLA LAVVQQKQNF----AQYQSF--NQAPMQRAHNIMGQGQESVQRNIS-------------- Q9W6B2_XENLA Q9W6B2_XENLA LAVVQQKQNF----AQYQNF--NQAPIHGAQNIMGQGQESVQRNIS-------------- Q9PSZ4_CHICK Q9PSZ4_CHICK ------------------------------------------------------------ GLI2_HUMAN GLI2_HUMAN LAVVQQKPAF----GQYPGY--SPQGLQASPGGLDSTQPHLQPRSG-------------- Q59FV5_HUMAN Q59FV5_HUMAN LAVVQQKPAF----GQYPGY--SPQGLQASPGGLDSTQPHLQPRSG-------------- Q0VGT2_MOUSE Q0VGT2_MOUSE LAVVQQKPAF----GQYPGY--NPQSVQSSSGGLDSTQPHLQL----------------- Q0VGV1_MOUSE Q0VGV1_MOUSE LAVVQQKPAF----GQYPGY--NPQSVQSSSGGLDSTQPHLQL--R-------------- GLI1_XENLA GLI1_XENLA VPESTKQGCPVNRNSCQQGMYMNNQKYNHGGQVQVKPEQQFHHSAPAMMSCQNMKHPSRQ Q4SS75_TETNG Q4SS75_TETNG ----------------------HSHIPTPAHELQSQ------------------------ Q800Z9_DANRE Q800Z9_DANRE QRVTVKPEQFHPSMGGSSSCQNTKALHQNRHNANMQTYPLQGQGIM-------------- MATCH CONSENSUS ????????????????????????????????????????????????????????????

B3DK55_DANRE B3DK55_DANRE -----------HMGGISYGCRNSEQHLQVAKPAQEKSRMKTGIKTESSSTFQLESKHSNF Q6U6Z9_DANRE Q6U6Z9_DANRE -----------HMGGISYGCRNSEQHLQVAKPAQEKSRMKTGIKTESSSTFQLESKHSNF Q4S1H8_TETNG Q4S1H8_TETNG ------------------------------------------------------------ GLI3_XENLA GLI3_XENLA DLYNNSNVWSGQLGRGNQYIDDIERSSLGHSATGSLCNSAARGQKLTTNGLPMNTGQQNF Q9I8Q1_COTCO Q9I8Q1_COTCO ----NGASSSFSMQPNKPYSESISRQPMISGAMDNSCGVTVQGQKLRSSNMPASGNQQNP Q9DF31_CHICK Q9DF31_CHICK ------------------------------------------------------------ Q9IA31_CHICK Q9IA31_CHICK ----SGASSSFGMQPNKPYGESVSRQPMIFGAMDSSCGITVQGQKLRSSNMPVSGNQQNF B2RUG4_MOUSE B2RUG4_MOUSE GLGTNGNTFHEQPFKTQQYGSQLNRQPLTSSALDHACGTGIQGSKLKGNSLQENGGLLDF GLI3_MOUSE GLI3_MOUSE GLGTNGNTFHEQPFKTQQYGSQLNRQPLTSSALDHACGTGIQGSKLKGNSLQENGGLLDF B7ZNV2_MOUSE B7ZNV2_MOUSE GLGTNGNTFHEQPFKTQQYGSQLNRQPLTSSALDHACGAGIQGSKLKGNSLQENGGLLDF Q5ISB1_9PRIM Q5ISB1_9PRIM ------------------------------------------------------------ GLI3_PANTR GLI3_PANTR GSGTSGNAFHEQPCKAPQYGNCLNRQPVAPGALDGACGAGIQASKLKSTPMQGSGGQLNF B4DRK1_HUMAN B4DRK1_HUMAN GSGTSGNAFHEQPCKAPQYGNCLNRQPVAPGALDGACGAGIQASKLKSTPMQGSGGQLNF GLI3_HUMAN GLI3_HUMAN GSGTSGNAFHEQPCKAPQYGNCLNRQPVAPGALDGACGAGIQASKLKSTPMQGSGGQLNF Q4SES2_TETNG Q4SES2_TETNG ------------------------------------------------------------ B3DGN8_DANRE B3DGN8_DANRE ----------QRINQRQANAEFLHGYLQ--GSASNDISLGLLNPSGKSLTVQPGGVQNNR Q5BN24_DANRE Q5BN24_DANRE ----------LRINQRQANAEFLHGYLQ--GSASNDISLGLLNPSGKSLTVQPGGVQNNR B0S6T1_DANRE B0S6T1_DANRE -----------RMNTVQQYRQSIS-NPCQ-NIGEQVNRQDLSYNSNQRLICNSMG----- Q9YGS4_DANRE Q9YGS4_DANRE -----------RMNTVQQFRQSIS-NPCQ-NIGEQVNRQDLSYNSNQRLICNSMG----- Q98SN1_DANRE Q98SN1_DANRE -----------RMNTVQQFRQSIS-NPCQ-NIGEQVNRQDLSYNSNQRLICNSMG----- Q4RK76_TETNG Q4RK76_TETNG -------HSNQRLTHASQPQQQQQRQYIPANFGQHMSPQQGFG---QEFIPNSISGSTSM GLI4_XENLA GLI4_XENLA -------VNGQRFNYLQQRQQQMSQCQ---IVSSDFIPQQRYSQSQSMLSSRAMQEGQSQ Q9W6B2_XENLA Q9W6B2_XENLA -------VNGQRFNYMQQRQQQMSQCQ---NVTSDFSPQQRYSQSQSMLNTRAMQEGQNL Q9PSZ4_CHICK Q9PSZ4_CHICK ------------------------------------------------------------ GLI2_HUMAN GLI2_HUMAN ----APSQGIPRVNYMQQLRQPVAGSQCP-GMTTTMSPHACYGQVHPQLSPSTISGALNQ Q59FV5_HUMAN Q59FV5_HUMAN ----APSQGIPRVNYMQQLRQPVAGSQCP-GMTTTMSPHACYGQVHPQLSPSTISGALNQ Q0VGT2_MOUSE Q0VGT2_MOUSE ----RGAPSASRGSYTQQPRQPAAGSQCL-GMSAAMSPQASYSQAHPQLSPNIVSGSLNQ Q0VGV1_MOUSE Q0VGV1_MOUSE -----GAPSASRGSYTQQPRQPAAGSQCL-GMSAAMSPQASYSQAHPQLSPNIVSGSLNQ GLI1_XENLA GLI1_XENLA EHHFTKTNTMPLSSEATNCDYQGQQDSTQNSCFNVGLNLNLLSPPGRRSQTPIMQVKEIM Q4SS75_TETNG Q4SS75_TETNG ------------------------------QGLQYTDAQHTHFNSQPGLYNSPGGTHKLV Q800Z9_DANRE Q800Z9_DANRE --------NRSSSASCDFHHSQMGTQPNQGGSFQSGTGINLALAESRRSQTPMHQMKEMM MATCH CONSENSUS ????????????????????????????????????????????????????????????

B3DK55_DANRE B3DK55_DANRE GRPDFSHIFS---APIHQKCSQH------------------------------------- Q6U6Z9_DANRE Q6U6Z9_DANRE GRPDFSHIFS---APIHQKCSQH------------------------------------- Q4S1H8_TETNG Q4S1H8_TETNG ------------------------------------------------------------ GLI3_XENLA GLI3_XENLA GPSTHYSVQS---ANRAEVVQNENIINQEFMQQMT------------------------- Q9I8Q1_COTCO Q9I8Q1_COTCO GHPITSSGQA---TDMADGMQNRNMMGQEYLENQLIGDGIHY------------------ Q9DF31_CHICK Q9DF31_CHICK ------------------------------------------------------------ Q9IA31_CHICK Q9IA31_CHICK GHPIASSDQA---TSMANGMQNRNVMEQEYLQNELVGDGIHY------------------ B2RUG4_MOUSE B2RUG4_MOUSE SLSVAPNELA---GNTVNGMQTQDQMGQGYIAHQLLSGSMQH------------------ GLI3_MOUSE GLI3_MOUSE SLSVAPNELA---GNTVNGMQTQDQMGQGYIAHQLLSGSMQH------------------ B7ZNV2_MOUSE B7ZNV2_MOUSE SLSVAPNELA---GNTVNGMQTQDQMGQGYVAHQLLSGSMQH------------------ Q5ISB1_9PRIM Q5ISB1_9PRIM ------------------------------------------------------------ GLI3_PANTR GLI3_PANTR GLPVAPNESA---GSMVNGMQNQDPVGQGYLAHQLLGDSMQH------------------ B4DRK1_HUMAN B4DRK1_HUMAN GLPVAPNESA---GSMVNGMQNQDPVGQGYLAHQLLGDSMQH------------------ GLI3_HUMAN GLI3_HUMAN GLPVAPNESA---GSMVNGMQNQDPVGQGYLAHQLLGDSMQH------------------ Q4SES2_TETNG Q4SES2_TETNG ------------------------------------------------------------ B3DGN8_DANRE B3DGN8_DANRE VRAQAQSHAT---FPN-------------------------------------------- Q5BN24_DANRE Q5BN24_DANRE VCAQAQSHAT---FPN-------------------------------------------- B0S6T1_DANRE B0S6T1_DANRE -PPNGRVVQN---QEL-------------------------------------------- Q9YGS4_DANRE Q9YGS4_DANRE -PPNGRMVQN---QEL-------------------------------------------- Q98SN1_DANRE Q98SN1_DANRE -PPNGRVVQN---QEL-------------------------------------------- Q4RK76_TETNG Q4RK76_TETNG RPAQNGMASS---EPQSYRARTQ------------------------------------- GLI4_XENLA GLI4_XENLA ISPSCNNMVE---RPG---------VHTHAAPSNTLNHQRLAVHGAPTQGFANNFSVN-- Q9W6B2_XENLA Q9W6B2_XENLA IPPSCNNMAE---RPG---------VHTHSAPSNTLSHQHLAVHGAPTQMFTNNFSVN-- Q9PSZ4_CHICK Q9PSZ4_CHICK ------------------------------------------------------------ GLI2_HUMAN GLI2_HUMAN FPQSCSNMPA---KPGHLG----HPQQTEVAPDPTTMGNRHRELGVPDSALAGVPPPHPV Q59FV5_HUMAN Q59FV5_HUMAN FPQSCSNMPA---KPGHLG----HPQQTEVAPDPTTMGNRHRELGVPDSALAGVPPPHPV Q0VGT2_MOUSE Q0VGT2_MOUSE FSPSCSNMAA---KPSHLG----LPQQMEVVPNATIMNGHQREHGVPNSSLAAVSQPHPV Q0VGV1_MOUSE Q0VGV1_MOUSE FSPSCSNMAA---KPSHLG----LPQQMEVVPNATIMNGHQREHGVPNSSLAAVSQPHPV GLI1_XENLA GLI1_XENLA VRNYVQSQQALMWEQHPKSMAMMTNSGDDVDTRQNQHKNTLNAAVYMGPKYMN------- Q4SS75_TETNG Q4SS75_TETNG IKPEQQFHVG-------------------------------------------------- Q800Z9_DANRE Q800Z9_DANRE VRNYVQSQQALLWEQQQEQSVSEKPDGMDMGQTQMMQHSPQHQQA--------------- MATCH CONSENSUS ????????????????????????????????????????????????????????????

B3DK55_DANRE B3DK55_DANRE ---------------TVVSQSYPQQNQITNQDSSNLFLQRPGNCSL---------LLAYR Q6U6Z9_DANRE Q6U6Z9_DANRE ---------------TVVSQSYPQQNQITNQDSSNLFLQRPGNCSL---------LLAYR Q4S1H8_TETNG Q4S1H8_TETNG ------------------------------------------------------------ GLI3_XENLA GLI3_XENLA ---------------AEHLIYGMHLLGVTRSNQTTSGQNGNTTDGTRSFLSTTQNGGEQ- Q9I8Q1_COTCO Q9I8Q1_COTCO ---------------QGVNQSGPMMLGQVSPTSQSSLYQGPQSCPP-----VFHTIGNQS Q9DF31_CHICK Q9DF31_CHICK ------------------------------------------------------------ Q9IA31_CHICK Q9IA31_CHICK ---------------QGVNQSSPMTLGQVSPTSQSSLHQGPQSCPP-----VSHTIGNQS B2RUG4_MOUSE B2RUG4_MOUSE ---------------QGPSRPGQQVLGQVGATSHINIYQGTESCLP-----GTQDNSSQP GLI3_MOUSE GLI3_MOUSE ---------------QGPSRPGQQVLGQVGATSHINIYQGTESCLP-----GTQDNSSQP B7ZNV2_MOUSE B7ZNV2_MOUSE ---------------QGPSRPGQQVLGQVGATSHINIYEGTESCLP-----GTQDNSSQP Q5ISB1_9PRIM Q5ISB1_9PRIM ------------------------------------------------------------ GLI3_PANTR GLI3_PANTR ---------------PGAGRPGQQMLGQISATSHINIYQGPESCLP-----GAHGMGSQP B4DRK1_HUMAN B4DRK1_HUMAN ---------------PGAGRPGQQMLGQISATSHINIYQGPESCLP-----GAHGMGSQP GLI3_HUMAN GLI3_HUMAN ---------------PGAGRPGQQMLGQISATSHINIYQGPESCLP-----GAHGMGSQP Q4SES2_TETNG Q4SES2_TETNG ------------------------------------------------------------ B3DGN8_DANRE B3DGN8_DANRE ---------------NQGNYSQMSSNQQ---GYIVASQNVNGS------------LLLQP Q5BN24_DANRE Q5BN24_DANRE ---------------NQGNYSQMSSNQQ---GYIVASQNVNGN------------LLLQP B0S6T1_DANRE B0S6T1_DANRE ---------------QNYRSNLMHMNNINQQNYVPLTQTAIQNAGR---------GLIQP Q9YGS4_DANRE Q9YGS4_DANRE ---------------QNYRSNLMHMNNINQQNYVPLTQTAFQNAGR---------GLIQP Q98SN1_DANRE Q98SN1_DANRE ---------------QNYRSNLMHMNNINQQNYVPLTQTAIQNAGR---------GLIQP Q4RK76_TETNG Q4RK76_TETNG ---------------TDGYCRVNPMDVQQNYNVLTQQHQSIHSGAR---------GSLQP GLI4_XENLA GLI4_XENLA ---------------QDGLHPPNAYTVQPQKNGLEPQQNTLGMSGQ-----AFNHGMIQP Q9W6B2_XENLA Q9W6B2_XENLA ---------------QDGLHPPNAYTVQTQKNGLEPQQNTLGMSGQ-----AFNHGMIQP Q9PSZ4_CHICK Q9PSZ4_CHICK ------------------------------------------------------------ GLI2_HUMAN GLI2_HUMAN QSYPQQSHHLAASMSQEGYHQVPSLLPARQPGFMEPQTGPMGVATA-------GFGLVQP Q59FV5_HUMAN Q59FV5_HUMAN QSYPQQSHHLAASMSQEGYHQVPSLLPARQPGFMEPQTGPMGVATA-------GFGLVQP Q0VGT2_MOUSE Q0VGT2_MOUSE LSYPQ----------QDSYQQGSNLLSSHQPGFMESQQNAGF-------------GLMQP Q0VGV1_MOUSE Q0VGV1_MOUSE LSYPQ----------QDSYQQGSNLLSSHQPGFMESQQNAGF-------------GLMQP GLI1_XENLA GLI1_XENLA ---------------YQGKPSPNNLMSPSSQDSQSSHTKAMGSPSS-----QCYNFDMMP Q4SS75_TETNG Q4SS75_TETNG ---------------MGGRDACQSAKLQQQRMLLQQAQ-----------------GYPQP Q800Z9_DANRE Q800Z9_DANRE ---------------NQNLYPGNTYQGYPNQNLMSPQQNRVPGSVKEQMQSSCYGPDMIP MATCH CONSENSUS ????????????????????????????????????????????????????????????

B3DK55_DANRE B3DK55_DANRE PQPAVNTSYSTRQDINSHNVQSCHPQSLNRLGTSCSPSN----QVSVVKLDQVNHLQ--- Q6U6Z9_DANRE Q6U6Z9_DANRE PQPAVNTSYSTRQDINSHNVQSCHPQSLNNRLGTSCSLSN---QVSVVKLDQVNHLQ--- Q4S1H8_TETNG Q4S1H8_TETNG ------------------------------------------------------------ GLI3_XENLA GLI3_XENLA -QPTLAKNFQSFVNSSGNSRQNLHRNNLPYLQEQIYDTNQHIFKVNSIKMEMQSHPQQ-- Q9I8Q1_COTCO Q9I8Q1_COTCO SGLSVAKSYQPCANYSGNRRQNVLRNNLTQQQGHVSDYNQTC-RVNTIKMEMQGQSQQ-- Q9DF31_CHICK Q9DF31_CHICK ------------------------------------------------------------ Q9IA31_CHICK Q9IA31_CHICK SGLSVAKSYQPCANYSGNRRQNVLRNNLAQQQGHVSDGNQTY-RVNTIKLEMQGQSQQ-- B2RUG4_MOUSE B2RUG4_MOUSE SSMAAIRGYQPCASYGGNRRQAMPRGNLTLQQGQLSDMSQSS-RVNSIKMEAQGQSQQ-- GLI3_MOUSE GLI3_MOUSE SSMAAIRGYQPCASYGGNRRQAMPRGNLTLQQGQLSDMSQSS-RVNSIKMEAQGQSQQ-- B7ZNV2_MOUSE B7ZNV2_MOUSE SSMAAIRGYQPCASYGGNRRQAMPRGNLTLQQGQLSDMSQSS-RVNSIKMEAQGQSQQ-- Q5ISB1_9PRIM Q5ISB1_9PRIM ------------------------------------------------------------ GLI3_PANTR GLI3_PANTR SSLAVVRGYQPCASFGGSRRQAMPRDSLALQSGQLSDTSQTC-RVNGIKMEMKGQPHP-- B4DRK1_HUMAN B4DRK1_HUMAN SSLAVVRGYQPCASFGGSRRQAMPRDSLALQSGQLSDTSQTC-RVNGIKMEMKGQPHP-- GLI3_HUMAN GLI3_HUMAN SSLAVVRGYQPCASFGGSRRQAMPRDSLALQSGQLSDTSQTC-RVNGIKMEMKGQPHP-- Q4SES2_TETNG Q4SES2_TETNG ------------------------------------------------------------ B3DGN8_DANRE B3DGN8_DANRE RPPTEPKPYSTQHSGPTTTAAK----------SNFSPAYDTS-EASPKK----------- Q5BN24_DANRE Q5BN24_DANRE RPPTEPKPYSTQHSGPTTTAAQ----------SNFSPAYDTS-EASPKK----------- B0S6T1_DANRE B0S6T1_DANRE RPPSEPKPLNRQHSGSGMVQPN----------GCSLSNVNSS-EASPKRPGEVGQHS--- Q9YGS4_DANRE Q9YGS4_DANRE RPPSEPKPLNRQHSGSGMVQPN----------GCSLSNVNSS-EASPKRPGEVGQHS--- Q98SN1_DANRE Q98SN1_DANRE RPPSEPKPLNRQHSGSGMVQPN----------GCSLSNVNSS-EASPKRPGEVGQHS--- Q4RK76_TETNG Q4RK76_TETNG RPPAEPRSSLRQHLGSNMMPPNRVPKSSAL---SPCDGNETS-EASPKRCSGLAAQNS-- GLI4_XENLA GLI4_XENLA RPPAAPHPPNRPRNIHPVHHPPYMRSPHPV--SELSPGQQTA-EATPKRTSENTDPTP-- Q9W6B2_XENLA Q9W6B2_XENLA RPPAAPHLPNRPRNIHPVHHPPYMRSPHPV--SELSPGQQTA-EATPKRTNEDTDPSP-- Q9PSZ4_CHICK Q9PSZ4_CHICK ------------------------------------------------------------ GLI2_HUMAN GLI2_HUMAN RPPLEPSPTGRHRGVRAVQQQLAYARATGHAMAAMPSSQETA-EAVPKGAMGNMGSVPPQ Q59FV5_HUMAN Q59FV5_HUMAN RPPLEPSPTGRHRGVRAVQQQLAYARATGHAMAAMPSSQETA-EAVPKGAMGNMGSVPPQ Q0VGT2_MOUSE Q0VGT2_MOUSE RPPLEPNTASRHRGVRSGQQQLYARTT--GQAMVTSANQETA-EAMPKGPAGTMVSLA-P Q0VGV1_MOUSE Q0VGV1_MOUSE RPPLEPNTASRHRGVRSGQQQLYARTT--GQAMVTSANQETA-EAMPKGPAGTMVSLA-P GLI1_XENLA GLI1_XENLA HPPCGPKPLSRQHSVSSQSTYMGSP-------NQLSPSYQSS-ESSPRRMACLPPIQPQS Q4SS75_TETNG Q4SS75_TETNG AGAVMMRNSSSSNCGFQAQNQTTFASGGSVSLGCAGKALSDG-QRSETPMMQVKEMM--- Q800Z9_DANRE Q800Z9_DANRE RPPQVRKSLSRQNSLSQQAGGAYLGSPPHLSPVHSTASPRRGVRLPPVQQQQQQQQQH-- MATCH CONSENSUS ????????????????????????????????????????????????????????????

B3DK55_DANRE B3DK55_DANRE ---------INSCSTIQQQKPVFIDKCFDPEESKLSHAIVQSCLMESLMAEKERTSKVLL Q6U6Z9_DANRE Q6U6Z9_DANRE ---------INSCSTIQQQKPVFIDKCFDPEESKLSHAIVQSCLMESLMAEKERTSKVLL Q4S1H8_TETNG Q4S1H8_TETNG ------------------------------------------------------------ GLI3_XENLA GLI3_XENLA ---------HCANAQNFSGQLYDQTATYPQQIMKSGSEPGME-ANCLLQESNNTNSSKLL Q9I8Q1_COTCO Q9I8Q1_COTCO ---------FCSNMQNYSGQLYDQPMGFSHQAMKTGSSFFVSEANCLLQETATANSSELL Q9DF31_CHICK Q9DF31_CHICK ------------------------------------------------------------ Q9IA31_CHICK Q9IA31_CHICK ---------FCSNMQNYSGQLYDQTTGFSHQAMKIGSSFFVSEANCLLQETATANSSELL B2RUG4_MOUSE B2RUG4_MOUSE ---------LCSTVQNYSGQFYDQTMGFSQQDRKAGSFSLSD--ANCLLQGNGTENSELL GLI3_MOUSE GLI3_MOUSE ---------LCSTVQNYSGQFYDQTMGFSQQDRKAGSFSLSD--ANCLLQGNGTENSELL B7ZNV2_MOUSE B7ZNV2_MOUSE ---------LCSTVQNYSGQFYDQTMGFSQQDRKAGSFSLSD--ANCLLQGNGTENSELL Q5ISB1_9PRIM Q5ISB1_9PRIM ------------------------------------------------------------ GLI3_PANTR GLI3_PANTR ---------LCSNLQNYSGQFYDQTVGFSQQDTKAGSFSISD--ASCLLQGTSAKNSELL B4DRK1_HUMAN B4DRK1_HUMAN ---------LCSNLQNYSGQFYDQTVGFSQQDTKAGSFSISD--ASCLLQGTSAKNSELL GLI3_HUMAN GLI3_HUMAN ---------LCSNLQNYSGQFYDQTVGFSQQDTKAGSFSISD--ASCLLQGTSAKNSELL Q4SES2_TETNG Q4SES2_TETNG ------------------------------------------------------------ B3DGN8_DANRE B3DGN8_DANRE -----------SSSMFYTGQIHMFDSSGAMPCP-----------------------SSVG Q5BN24_DANRE Q5BN24_DANRE -----------SSSMFYTGQIHMFDSSGAMPCP-----------------------SSVG B0S6T1_DANRE B0S6T1_DANRE ---------NGNGTMYYSGEIHMLDNGIDYGSPMSPCTNQAP----------VASVSTMA Q9YGS4_DANRE Q9YGS4_DANRE ---------NGNGTMYYSGEIHMLDNGIDYGSPMSPCTNQAP----------VASVSTMA Q98SN1_DANRE Q98SN1_DANRE ---------NGNGTMYYSGEIHMLDNGIDYGSPMSPCTNQAP----------VASVSTMA Q4RK76_TETNG Q4RK76_TETNG ---------NSENSVFYTGQIHMFEPSFD--APMSPCASEPP--------ANSTTAASMA GLI4_XENLA GLI4_XENLA ---------KDNNLLYYSGQIHMYEPNGNFGSGIDCTVRQLP---------------TMP Q9W6B2_XENLA Q9W6B2_XENLA ---------KDNNLLYYSGQIHMYEPNGNFSSGIDCTAQQLP---------------TMP Q9PSZ4_CHICK Q9PSZ4_CHICK ------------------------------------------------------------ GLI2_HUMAN GLI2_HUMAN PPPQDAGGAPDHSMLYYYGQIHMYEQDGGLEN-LGSCQVMRSQPPQPQACQDSIQPQPLP Q59FV5_HUMAN Q59FV5_HUMAN PPPQDAGGAPDHSMLYYYGQIHMYEQDGGLEN-LGSCQVMRSQPPQPQACQDSIQPQPLP Q0VGT2_MOUSE Q0VGT2_MOUSE QPSQDTGRAQDQNTLYYYGQIHMYEQNG-------GCPAVQPQPPQPQACSDSIQPEPLP Q0VGV1_MOUSE Q0VGV1_MOUSE QPSQDTGRAQDQNTLYYYGQIHMYEQNG-------GCPAVQPQPPQPQACSDSIQPEPLP GLI1_XENLA GLI1_XENLA EVT------NNTSMMYYTGQMEMHQSKPGVHKLTTPLNLNQTSCDGHQHGQYNASHSFLK Q4SS75_TETNG Q4SS75_TETNG ---------VRNYVQSQQALMWEQQQEQQQQNPTGDSKSVPL----------------SP Q800Z9_DANRE Q800Z9_DANRE ----SENFNNNNNPMYYSGQMHMHHD--LEKTPEGPCLAQQH----LTSSDPTTKPTSIS MATCH CONSENSUS ????????????????????????????????????????????????????????????

B3DK55_DANRE B3DK55_DANRE SSGVGQVTSKV--------ERSPAEKVGLGICSIGGD------------SYDQGSVVSSS Q6U6Z9_DANRE Q6U6Z9_DANRE SSGVGQVTSKV--------ERSPAEKVGLGICSIGGD------------SYDQGSVVSSS Q4S1H8_TETNG Q4S1H8_TETNG ------------------------------------------------------------ GLI3_XENLA GLI3_XENLA SPGANHVTSTV---DNI-DNSLAGVQIAFAAIIDDGDHASLISGVLSP-SIIQNLSRNSS Q9I8Q1_COTCO Q9I8Q1_COTCO SPGANQVSSTV---DSLDNNSLEGVQIDFDAIIDDGDHVSLISGALSP-SIIQNLSRNSS Q9DF31_CHICK Q9DF31_CHICK ------------------------------------------------------------ Q9IA31_CHICK Q9IA31_CHICK SPGANQVSSTV---DSLDSNSLEGVQIDFDAIIDDGDHVSLISGALSP-SIIQNLSRNSS B2RUG4_MOUSE B2RUG4_MOUSE SPGANQVTSTV---DSFESHDLEGVQIDFDAIIDDGDHTSLMSGALSP-SIIQNLSHSSS GLI3_MOUSE GLI3_MOUSE SPGANQVTSTV---DSFESHDLEGVQIDFDAIIDDGDHTSLMSGALSP-SIIQNLSHSSS B7ZNV2_MOUSE B7ZNV2_MOUSE SPGANQVTSTV---DSFESHDLEGVQIDFDAIIDDGDHTSLMSGALSP-SIIQNLSHSSS Q5ISB1_9PRIM Q5ISB1_9PRIM ------------------------------------------------------------ GLI3_PANTR GLI3_PANTR SPGANQVTSTV---DSLDSHDLEGVQIDFDAIIDDGDHSSLMSGALSP-SIIQNLSYSSS B4DRK1_HUMAN B4DRK1_HUMAN SPGANQVTSTV---DSLDSHDLEGVQIDFDAIIDDGDHSSLMSGALSP-SIIQNLSHSSS GLI3_HUMAN GLI3_HUMAN SPGANQVTSTV---DSLDSHDLEGVQIDFDAIIDDGDHSSLMSGALSP-SIIQNLSHSSS Q4SES2_TETNG Q4SES2_TETNG ------------------------------------------------------------ B3DGN8_DANRE B3DGN8_DANRE SPETNQVSSTV---DS---SGADPPQIDFDAMLDDGDHSSLMSGTLSP-ALLRSLSQNSS Q5BN24_DANRE Q5BN24_DANRE SPETNQVSSTV------DSSGADPPQIDFDAMLDDGDHSSLMSGTLSP-ALLRSLSQNSS B0S6T1_DANRE B0S6T1_DANRE SPGVNQVTSTV---DS--TQSLDHTQIDFDAMLDDGDHSSLMSGTLSP-GLLQSISQNSS Q9YGS4_DANRE Q9YGS4_DANRE SPGVNQVTSTV---DS--TQSLDHTQIDFDAMLDDGDHSSLMSGTLSP-GLLQSISQNSS Q98SN1_DANRE Q98SN1_DANRE SPGVNQVTSTV---DS--TQSLDHTQIDFDAMLDDGDHSSLMSGTLSP-GLLQSISQNSS Q4RK76_TETNG Q4RK76_TETNG SPGVNLVSSSTTDSSTGASGGAQHPQIDFDTMLDDGDHSSLMSGTLSP-GLLQSLSQSSS GLI4_XENLA GLI4_XENLA SPGANQVTSTV---DS--QGLEHPPVIDFDAMMDDGDHSSLMSGTLSP-GLLQSFSQTSS Q9W6B2_XENLA Q9W6B2_XENLA SPGANQVTSTV---DS--QGLEHPPVIDFDTMMDDGDHSSLMSGTLSP-GLLHSFSQTSS Q9PSZ4_CHICK Q9PSZ4_CHICK ---------------------------EFDIKL--------------------------- GLI2_HUMAN GLI2_HUMAN SPGVNQVSSTV---DS---QLLEAPQIDFDAIMDDGDHSSLFSGALSP-SLLHSLSQNSS Q59FV5_HUMAN Q59FV5_HUMAN SPGVNQVSSTV------DSQLLEAPQIDFDAIMDDGDHSSLFSGALSP-SLLHSLSQNSS Q0VGT2_MOUSE Q0VGT2_MOUSE SPGVNQVSSTV---DS---QLLEPPQIDFDAIMDDGDHSSLFSGALSP-TLLHNLSQNSS Q0VGV1_MOUSE Q0VGV1_MOUSE SPGVNQVSSTV---DS---QLLEPPQIDFDAIMDDGDHSSLFSGALSP-TLLHNLSQNSS GLI1_XENLA GLI1_XENLA TVPYTSSCPAA---NTLDSLDLENTQIDFTAIIDDAD-NALMPGNISP-NVLAGSSQASS Q4SS75_TETNG Q4SS75_TETNG YAESGPIANAL------ENLDLDNTRIDFTSIIEDAESSSFGPINNTLEGQPGPSSQASS Q800Z9_DANRE Q800Z9_DANRE YPDPAPMSNAL------EHLDLENAQIDFTSIIDDQEPSSY-SPINAPIGHNQCSSQTSS MATCH CONSENSUS ????????????????????????????F?????????????????????????????SS

B3DK55_DANRE B3DK55_DANRE RLSNSHDSFAFHSVDPGTNNMAISDMNSLLTTLAEESKFLAIIQ Q6U6Z9_DANRE Q6U6Z9_DANRE RLSNSHDSFAFHSVDPGTNNMAISDMNSLLTTLAEESKFLAIIQ Q4S1H8_TETNG Q4S1H8_TETNG -------------------------------------------- GLI3_XENLA GLI3_XENLA RLTTPRASLTFPAIPVSTSNMAIGDMSSLLTSLAEESKFLAIMQ Q9I8Q1_COTCO Q9I8Q1_COTCO RLTTPRASLTFPAVPVSTTNMAIGDMSSLLTSLAEESKFLAVMQ Q9DF31_CHICK Q9DF31_CHICK -------------------------------------------- Q9IA31_CHICK Q9IA31_CHICK RLTTPRASLTFP-------------------------------- B2RUG4_MOUSE B2RUG4_MOUSE RLTTPRASLPFPSLSMGTTNMAIGDMSSLLTSLAEESKFLAVMQ GLI3_MOUSE GLI3_MOUSE RLTTPRASLPFPSLSMGTTNMAIGDMSSLLTSLAEESKFLAVMQ B7ZNV2_MOUSE B7ZNV2_MOUSE RLTTPRASLPFPSLSMGTTNMAIGDMSSLLTSLAEESKFLAVMQ Q5ISB1_9PRIM Q5ISB1_9PRIM -------------------------------------------- GLI3_PANTR GLI3_PANTR RLTTPRASLPFPALSMSTTNMAIGDMSSLLTSLAEESKFLAVMQ B4DRK1_HUMAN B4DRK1_HUMAN RLTTPRASLPFPALSMSTTNMAIGDMSSLLTSLAEESKFLAVMQ GLI3_HUMAN GLI3_HUMAN RLTTPRASLPFPALSMSTTNMAIGDMSSLLTSLAEESKFLAVMQ Q4SES2_TETNG Q4SES2_TETNG -------------------------------------------- B3DGN8_DANRE B3DGN8_DANRE RLTTPRNSVTLPPVAAGISNMAIGDMSSMLTALAEESKFLNMMS Q5BN24_DANRE Q5BN24_DANRE RLTTPRNSVTLPPVAAGISNMAIGDMSSMLTALAEESKFLNMMS B0S6T1_DANRE B0S6T1_DANRE RLTTPRNSVTLASVPAGIGNMAIGDMSSMLTALAEESKFLNMMA Q9YGS4_DANRE Q9YGS4_DANRE RLTTPRNSVTLASVPAGIGNMAIGDMSSMLTALAEESKFLNMMA Q98SN1_DANRE Q98SN1_DANRE RLTTPRNSVTLASVPAGIGNMAIGDMSSMLTALAEESKFLNMMA Q4RK76_TETNG Q4RK76_TETNG RLTTPRNSLPLASVPAGIGNMAIGDMNSMLTALAEESKFLNMMS GLI4_XENLA GLI4_XENLA RLTTPRNSLTLPSIPAGINNMAIGDMSSMLTTLAEESKFLNLMS Q9W6B2_XENLA Q9W6B2_XENLA RLTTPRNSLTLPSIPAGISNMAIGDMSSMLTTLAEESKFLNLMS Q9PSZ4_CHICK Q9PSZ4_CHICK -------------------------------------------- GLI2_HUMAN GLI2_HUMAN RLTTPRNSLTLPSIPAGISNMAVGDMSSMLTSLAEESKFLNMMT Q59FV5_HUMAN Q59FV5_HUMAN RLTTPRNSLTLPSIPAGISNMAVGDMSSMLTSLAEESKFLNMMT Q0VGT2_MOUSE Q0VGT2_MOUSE RLTTPRNSLTLPSIPAGISNMAVGDMSSMLTSLAEESKFLNMMT Q0VGV1_MOUSE Q0VGV1_MOUSE RLTTPRNSLTLPSIPAGISNMAVGDMSSMLTSLAEESKFF---- GLI1_XENLA GLI1_XENLA HLTTLRNTGAV------VPNMVVGDLNSMLSSLAGENKYLNTM- Q4SS75_TETNG Q4SS75_TETNG RLTTPQNSVSL-SAESGLSNMAVGDMTSMLTSLAGENKFLNTLS Q800Z9_DANRE Q800Z9_DANRE RLTTPQNSITLPS---GLSNMAIGDMSSMLTSLAGENKYLNTLS MATCH CONSENSUS RL?????S???????????NM???D??S?L??LA?E?K??????


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