Alignment of the gene Family HBG005954 of HOVERGEN

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Isoforms are ON
HEM0_CHICK HEM0_CHICK ------------------------------------------MAAFLR-CPLLARHPP-- Q86LZ7_BRALA Q86LZ7_BRALA ------------------------------------------------------------ Q9XYA5_MYXGL Q9XYA5_MYXGL NHSIGTFHKAFQSIATMATMARCQLFLSPYKWKSCYPSRTLAMATIVRRCPFLARVPQTF Q4S5J1_TETNG Q4S5J1_TETNG ------------------------------------------------------------ Q6EEC3_PRODO Q6EEC3_PRODO ------------------------------------------------------------ Q6EEC4_LATCH Q6EEC4_LATCH ------------------------------------------------------------ Q6DKE7_XENLA Q6DKE7_XENLA ------------------------------------------METIVRRCPFLSRVSQTF Q28HS9_XENTR Q28HS9_XENTR ------------------------------------------MDTIVRRCPFLSRVSQTF Q66JC7_XENTR Q66JC7_XENTR ------------------------------------------MDTIVRRCPFLSRVSQTF Q6EE56_XENLA Q6EE56_XENLA ------------------------------------------------------------ Q6PAZ6_XENLA Q6PAZ6_XENLA ------------------------------------------MDTIVRRCPFLARVSQTF HEM1_CHICK HEM1_CHICK ------------------------------------------MEAVVRRCPFLARVSQAF HEM1_DELLE HEM1_DELLE ------------------------------------------METVVRRCPFLSRVPQAF HEM1_MOUSE HEM1_MOUSE ------------------------------------------METVVRRCPFLSRVPQAF Q3V0B2_MOUSE Q3V0B2_MOUSE ------------------------------------------METVVRRCPFLSRVPQAF HEM1_RAT HEM1_RAT ------------------------------------------METVVRRCPFLSRVPQAF Q4R6D0_MACFA Q4R6D0_MACFA ------------------------------------------METVVRRCPFLSRVPQAF HEM1_PONAB HEM1_PONAB ------------------------------------------METVVRSCPFLSRVPQAF B4DVA0_HUMAN B4DVA0_HUMAN -------------------------MDEWLLLHLDEPAYFLNMESVVRRCPFLSRVPQAF HEM1_HUMAN HEM1_HUMAN ------------------------------------------MESVVRRCPFLSRVPQAF Q5JAM2_HUMAN Q5JAM2_HUMAN ------------------------------------------MESVVRRCPFLSRVPQAF B4DDG9_HUMAN B4DDG9_HUMAN ------------------------------------------------------------ HEM1_BOVIN HEM1_BOVIN ------------------------------------------METVVRRCPFLSRVPQAF Q401C4_CAPHI Q401C4_CAPHI ------------------------------------------------------------ Q7T2F0_DANRE Q7T2F0_DANRE ------------------------------------------MDAIIR-CPFLSRVPQTF B5X2H2_SALSA B5X2H2_SALSA ------------------------------------------MDTIIRRCPFLSRVPQAF HEM1_OPSTA HEM1_OPSTA ------------------------------------------MDVIVRRCPFLARVPQAF Q4RX09_TETNG Q4RX09_TETNG ------------------------------------------MDVLLRRCPFLARMPQTF HEM0_BOVIN HEM0_BOVIN ---------------------------------------MVTAAMLLQRCPVLIRSPTGL HEM0_DELLE HEM0_DELLE --------------------------------------------MLLQRCPVLIRSPTAI HEM0_RAT HEM0_RAT ---------------------------------------MVAAAMLLRSCPVLSKGPTGL Q642C1_RAT Q642C1_RAT ---------------------------------------MVAAAMLLRSCPVLSKGPTGL Q8R1G3_MOUSE Q8R1G3_MOUSE ------------------------------------------------------------ Q3TNI1_MOUSE Q3TNI1_MOUSE ---------------------------------------MVAAAMLLRSCPVLSQGPTGL Q3TA47_MOUSE Q3TA47_MOUSE ---------------------------------------MVAAAMLLRSCPVLSQGPTGL A2AFM1_MOUSE A2AFM1_MOUSE ---------------------------------------MVAAAMLLRSCPVLSQGPTGL A2AFM0_MOUSE A2AFM0_MOUSE ---------------------------------------MVAAAMLLRSCPVLSQGPTGL HEM0_MOUSE HEM0_MOUSE ---------------------------------------MVAAAMLLRSCPVLSQGPTGL Q9DDC3_PLAFE Q9DDC3_PLAFE ------------------------------------------------------------ B7ZB88_HUMAN B7ZB88_HUMAN ------------------------------------------------------------ HEM0_PONAB HEM0_PONAB ---------------------------------------MVTAAMLLQCCPVPARGPTSL A8K3F0_HUMAN A8K3F0_HUMAN ---------------------------------------MVTAAMLLQCCPVLARGPTSL HEM0_HUMAN HEM0_HUMAN ---------------------------------------MVTAAMLLQCCPVLARGPTSL A8K6C4_HUMAN A8K6C4_HUMAN ---------------------------------------MVTAAMLLQCCPVLARGPTSL Q8N6H3_HUMAN Q8N6H3_HUMAN ---------------MRGGEVALGWNKKKRLFCEDFRFKMVTAAMLLQCCPVLARGPTSL Q5JZF5_HUMAN Q5JZF5_HUMAN ---------------MRGGEVALGWNKKKRLFCEDFRFKMVTAAMLLQCCPVLARGPTSL HEM0_DANRE HEM0_DANRE ------------------------------------------MSAFLHHCPFLKSSPGPS Q4SYE6_TETNG Q4SYE6_TETNG ------------------------------------------MAAFLHHCPFLKSGPNPA HEM0_OPSTA HEM0_OPSTA ------------------------------------------MAAFLHHCPFLKSMPKPA Q6I749_ORYLA Q6I749_ORYLA ------------------------------------------------------------ Q6EEC2_LATCH Q6EEC2_LATCH ------------------------------------------------------------ Q6EEC1_PRODO Q6EEC1_PRODO ------------------------------------------------------------ Q5XG49_XENLA Q5XG49_XENLA -------------------------------------------------CPYATRDPTLF Q68F30_XENLA Q68F30_XENLA ------------------------------------------MASLINRCPFATRDPTVF Q6DF22_XENTR Q6DF22_XENTR ------------------------------------------MASLINRCPFATRDPTVF MATCH CONSENSUS ????????????????????????????????????????????????????????????

HEM0_CHICK HEM0_CHICK ------------------------------------------------------------ Q86LZ7_BRALA Q86LZ7_BRALA ------------------------------------------------------------ Q9XYA5_MYXGL Q9XYA5_MYXGL LQHAGKS--LLTYAERCPVMMEGLTQCP----ARPLSTAIPTFQQKNTNT---------- Q4S5J1_TETNG Q4S5J1_TETNG ------------------------------------------------------------ Q6EEC3_PRODO Q6EEC3_PRODO ------------------------------------------------------------ Q6EEC4_LATCH Q6EEC4_LATCH ------------------------------------------------------------ Q6DKE7_XENLA Q6DKE7_XENLA LQKAGKS--LVTYAQNCPVMMGTKPLSC----AQ-LSTSAVHQQETKETSDSKTPLNGPQ Q28HS9_XENTR Q28HS9_XENTR LQKAGKS--LVTYAQNCPVMMGTKPLSC-----ASLSTSAVHQQETKETSDSKTPLNRTQ Q66JC7_XENTR Q66JC7_XENTR LQKAGKS--LVTYAQNCPVMMGTKPLSC----A-SLSTSAVHQQETKETSDSKTPLNRTQ Q6EE56_XENLA Q6EE56_XENLA ------------------------------------------------------------ Q6PAZ6_XENLA Q6PAZ6_XENLA LQKAGKS--LVTYAQNCPVMMGTKPSSC----A-QLSTSAVHQQETKETSDSKRPLNGTQ HEM1_CHICK HEM1_CHICK LQKAGPS--LLFYAQHCPKMMEAAPPAA----ARGLATSASRGQQVEETPAAQPEAKKAK HEM1_DELLE HEM1_DELLE LQKAGKS--LLFYAQNCPKMMEVGAKPA----PRALSASAVLCQQVKETPPANEKDKTAK HEM1_MOUSE HEM1_MOUSE LQKAGKS--LLFYAQNCPKMMEVGAKPA----PRTLSTSAVHCQQVKETPPANEKEKTAK Q3V0B2_MOUSE Q3V0B2_MOUSE LQKAGKS--LLFYAQNCPKMMEVGAKPA----PRTLSTSAVHCQQVKETPPANEKEKTAK HEM1_RAT HEM1_RAT LQKAGKS--LLFYAQNCPKMMEVGAKPA----PRTVSTSAAQCQQVKETPPANEKEKTAK Q4R6D0_MACFA Q4R6D0_MACFA LQKAGKS--LLFYAQNCPKMMEVGAKPA----PRALSTAAVHYQQIKETSPASEKDKTAK HEM1_PONAB HEM1_PONAB LQKAGKS--LLFYAQNCPKMMEVGAKPA----PRALSTAAVHYQQIKETPPASEKDKTAK B4DVA0_HUMAN B4DVA0_HUMAN LQKAGKS--LLFYAQNCPKMMEVGAKPA----PRALSTAAVHYQQIKETPPASEKDKTAK HEM1_HUMAN HEM1_HUMAN LQKAGKS--LLFYAQNCPKMMEVGAKPA----PRALSTAAVHYQQIKETPPASEKDKTAK Q5JAM2_HUMAN Q5JAM2_HUMAN LQKAGKS--LLFYAQNCPKMMEVGAKPA----PRALSTAAVHYQQIKETPPASEKDKTAK B4DDG9_HUMAN B4DDG9_HUMAN ------------------------------------------------------------ HEM1_BOVIN HEM1_BOVIN LQKAGKS--LLFYAQNCPKMMEIGAKPA----PRALSTSAVLCQQVTETPPANEKDKAAK Q401C4_CAPHI Q401C4_CAPHI ------------------------------------------------------------ Q7T2F0_DANRE Q7T2F0_DANRE LQQARKS--LVAYAVKCPVMMDLASRPL----LRPLCSSSASFQKVEDSSSAGHEAS--- B5X2H2_SALSA B5X2H2_SALSA FQQARKS--LVVYAQKCPVMMDLASKPL----ARSLCSSSASFQKADDTVTSAQTSVEKV HEM1_OPSTA HEM1_OPSTA FQQSKKS--LAVYAQRCPFMMELASKPMAPSLARALCSSSSSQQKIEDTMSTGEVLKPK- Q4RX09_TETNG Q4RX09_TETNG LQQTKNS--LLGFAQKCPVMMELASKPMPPVMARALCSSSSSSPSYPNTEEKMSASEGCK HEM0_BOVIN HEM0_BOVIN LGKMIKTHQFLFGIGRCPILATQGPSFS----QIHLKATKAG------------------ HEM0_DELLE HEM0_DELLE LGKMIKTHQFLIGIGRCPILATQGTTCS----QIHLKATKAG------------------ HEM0_RAT HEM0_RAT LGKVAKTYQFLFGIGRCPILATQGPTCS----QIHLKATKAG------------------ Q642C1_RAT Q642C1_RAT LGKVAKTYQFLFGIGRCPILATQGPTCS----QIHLKATKAG------------------ Q8R1G3_MOUSE Q8R1G3_MOUSE ------------------------------------------------------------ Q3TNI1_MOUSE Q3TNI1_MOUSE LGKVAKTYQFLFSIGRCPILATQGPTCS----QIHLKATKAG------------------ Q3TA47_MOUSE Q3TA47_MOUSE LGKVAKTYQFLFSIGRCPILATQGPTCS----QIHLKATKAG------------------ A2AFM1_MOUSE A2AFM1_MOUSE LGKVAKTYQFLFSIGRCPILATQGPTCS----QIHLKATKAG------------------ A2AFM0_MOUSE A2AFM0_MOUSE LGKVAKTYQFLFSIGRCPILATQGPTCS----QIHLKATKAG------------------ HEM0_MOUSE HEM0_MOUSE LGKVAKTYQFLFSIGRCPILATQGPTCS----QIHLKATKAG------------------ Q9DDC3_PLAFE Q9DDC3_PLAFE ------------------------------------------------------------ B7ZB88_HUMAN B7ZB88_HUMAN ---------LSFVRPQCRA----------------------------------------- HEM0_PONAB HEM0_PONAB LGKVVKTHQFLFGIGRCPILATQGPNCS----QIHLKATKAG------------------ A8K3F0_HUMAN A8K3F0_HUMAN LGKVVKTHQFLFGIGRCPILATQGPNCS----QIHLKATKAG------------------ HEM0_HUMAN HEM0_HUMAN LGKVVKTHQFLFGIGRCPILATQGPNCS----QIHLKATKAG------------------ A8K6C4_HUMAN A8K6C4_HUMAN LGKVVKTHQFLFGIGRCPILATQGPNCS----QIHLKATKAG------------------ Q8N6H3_HUMAN Q8N6H3_HUMAN LGKVVKTHQFLFGIGRCPILATQGPNCS----QIHLKATKAG------------------ Q5JZF5_HUMAN Q5JZF5_HUMAN LGKVVKTHQFLFGIGRCPILATQGPNCS----QIHLKATKAG------------------ HEM0_DANRE HEM0_DANRE ARKVAT---YLNLADRCPIIVRQISAKA----AQSSEQNGLLPHKEPKRQLATTA----- Q4SYE6_TETNG Q4SYE6_TETNG LRRSGTA--LLSMAHLCPIIARQISVSS----IAAPGEDLAISPAKPTADQRRPLTQTS- HEM0_OPSTA HEM0_OPSTA LRRRVPA--LLSLADRCPVIVHQVCISR----LHILETKLDVSPTQPKRQRLSLLDQKRL Q6I749_ORYLA Q6I749_ORYLA ------------------------------------------------------------ Q6EEC2_LATCH Q6EEC2_LATCH ------------------------------------------------------------ Q6EEC1_PRODO Q6EEC1_PRODO ------------------------------------------------------------ Q5XG49_XENLA Q5XG49_XENLA LRVARPF--LLRCAERCPVMVTHSLSTS----PGCEQRAKDIPPTTGISTGASNRRTLA- Q68F30_XENLA Q68F30_XENLA LRVARPF--LLRSAERCPIMVTRSLSTS----AGCEQRAKDIPPATGVSTGASNRRTLAQ Q6DF22_XENTR Q6DF22_XENTR LRVARPF--LLRSAERCPVMVTCTLSTS----PGCEQRTKDTTPVTGVSTGASNRRTLAQ MATCH CONSENSUS ????????????????????????????????????????????????????????????

HEM0_CHICK HEM0_CHICK --------------------------------LARAFA---TGARCPFM---------GF Q86LZ7_BRALA Q86LZ7_BRALA ------------------------------------------------------------ Q9XYA5_MYXGL Q9XYA5_MYXGL --------------------------------GTEESA---TASRCPFLANEMGKRDGAV Q4S5J1_TETNG Q4S5J1_TETNG ------------------------------------------------------------ Q6EEC3_PRODO Q6EEC3_PRODO ------------------------------------------------------------ Q6EEC4_LATCH Q6EEC4_LATCH ------------------------------------------------------------ Q6DKE7_XENLA Q6DKE7_XENLA VQ--------------------GSQVPV-HPGMVSGQ----SASKCPFLAAQMIQENSSV Q28HS9_XENTR Q28HS9_XENTR VQGGL----------------TGSQVPADHPGAVSGQ----SASKCPFLAAQMVQENSSV Q66JC7_XENTR Q66JC7_XENTR VQGGL----------------TGSQVPADHP-GAVSGQ---SASKCPFLAAQMVQENSSV Q6EE56_XENLA Q6EE56_XENLA ------------------------------------------------------------ Q6PAZ6_XENLA Q6PAZ6_XENLA AQGGV----------------TGSQVPADHP-DVASGQ---SASKCPFLAAQMTQEYSGV HEM1_CHICK HEM1_CHICK EVAQQNT--------------DGSQPPAGHPPAAAVQS---SATKCPFLAAQMNHKSSNV HEM1_DELLE HEM1_DELLE AKVQQAPDGSQQTP-------DGTQLPSGHPSLAASQG---TASKCPFLAAQMSQGGSSV HEM1_MOUSE HEM1_MOUSE AAVQQAPDESQMAQ-----TPDGTQLPSGHPSPATSQG---SGSKCPFLAAQLSQTGSSV Q3V0B2_MOUSE Q3V0B2_MOUSE AAVQQAPDESQMAQ-----TPDGTQLPSGHPSPATSQG---SGSKCPFLAAQLSQTGSSV HEM1_RAT HEM1_RAT AAVQQAPDESQMAQ-----TPDGTQLPPGHPSPSTSQS---SGSKCPFLAAQLSQTGSSV Q4R6D0_MACFA Q4R6D0_MACFA ATVQQAPDGSQQSP-------DGTQLPSGHPLPATSQG---TASKCPFLAAQMNQRGSSV HEM1_PONAB HEM1_PONAB AKVQQTPDGSQQSP-------DGTQLPSGHPLPATSQG---TASKCPFLAAQMNQRGSSV B4DVA0_HUMAN B4DVA0_HUMAN AKVQQTPDGSQQSP-------DGTQLPSGHPLPATSQG---TASKCPFLAAQMNQRGSSV HEM1_HUMAN HEM1_HUMAN AKVQQTPDGSQQSP-------DGTQLPSGHPLPATSQG---TASKCPFLAAQMNQRGSSV Q5JAM2_HUMAN Q5JAM2_HUMAN AKVQQTPDGSQQSP-------DGTQLPSGHPLPATSQG---TASKCPFLAAQMNQRGSSV B4DDG9_HUMAN B4DDG9_HUMAN ----------------------------------------------------MNQRGSSV HEM1_BOVIN HEM1_BOVIN AEVQQAPDGSQQAPDGSQQTADGTQLPSGHPSLASSQG---TGSKCPFLAAEMSQGGSSV Q401C4_CAPHI Q401C4_CAPHI ------------------------------------------------------------ Q7T2F0_DANRE Q7T2F0_DANRE ---------------------DAPAVPAGHPAPPAGHA---SASKCPFLAAEMSQKNSGV B5X2H2_SALSA B5X2H2_SALSA ADGG-----------------TTTKLPQSHPHPMPPSGQASVASKCPFLAAEMGQ-NSSV HEM1_OPSTA HEM1_OPSTA ---------------------AEAKLPVGLATPPSNEA---VAPKCPFLAAEMGQNNSNV Q4RX09_TETNG Q4RX09_TETNG QA-------------------GESKLPAGHPVPPSGQA---LASKCPFLAAEMGQKNSSV HEM0_BOVIN HEM0_BOVIN --------------------------------GDSPSW---AKSHCPFMLLELQDGKSKI HEM0_DELLE HEM0_DELLE --------------------------------GDSPSW---AKSHCPFMLLELQDGKSKI HEM0_RAT HEM0_RAT --------------------------------ADSPSW---TKSHCPFMLSELQDRKSKI Q642C1_RAT Q642C1_RAT --------------------------------ADSPSW---TKSHCPFMLSELQDRKSKI Q8R1G3_MOUSE Q8R1G3_MOUSE ------------------------------------------------------------ Q3TNI1_MOUSE Q3TNI1_MOUSE --------------------------------GDSPSW---AKSHCPFMLSELQDRKSKI Q3TA47_MOUSE Q3TA47_MOUSE --------------------------------GDSPSW---AKSHCPFMLSELQDRKSKI A2AFM1_MOUSE A2AFM1_MOUSE --------------------------------G------------------ELQDRKSKI A2AFM0_MOUSE A2AFM0_MOUSE --------------------------------GDSPSW---AKSHCPFMLSELQDRKSKI HEM0_MOUSE HEM0_MOUSE --------------------------------GDSPSW---AKSHCPFMLSELQDRKSKI Q9DDC3_PLAFE Q9DDC3_PLAFE ------------------------------------------------------------ B7ZB88_HUMAN B7ZB88_HUMAN --------------------------------TDSPSW---AKGHCPFMLSELQDGKSKI HEM0_PONAB HEM0_PONAB --------------------------------GDSPSW---AKGHCPFMLSELQDGKSKI A8K3F0_HUMAN A8K3F0_HUMAN --------------------------------GDSPSW---AKGHCPFMLSELQDGKSKI HEM0_HUMAN HEM0_HUMAN --------------------------------GDSPSW---AKGHCPFMLSELQDGKSKI A8K6C4_HUMAN A8K6C4_HUMAN --------------------------------GDSPSW---AKGHCPFMLSELQDGKSKI Q8N6H3_HUMAN Q8N6H3_HUMAN --------------------------------GDSPSW---AKGHCPFMLSELQDGKSKI Q5JZF5_HUMAN Q5JZF5_HUMAN --------------------------------GDSPSW---AKGHCPFMLSELQDGKSKI HEM0_DANRE HEM0_DANRE --------------------------------TQVAVS---MSQSCPFVSSKIG------ Q4SYE6_TETNG Q4SYE6_TETNG --------------------------------PQVDVS---VAKGCPFVTSRIG------ HEM0_OPSTA HEM0_OPSTA FAQTA---------------------------TQVAVS---VSKGCPFVSSQIG------ Q6I749_ORYLA Q6I749_ORYLA ------------------------------------------------------------ Q6EEC2_LATCH Q6EEC2_LATCH ------------------------------------------------------------ Q6EEC1_PRODO Q6EEC1_PRODO ------------------------------------------------------------ Q5XG49_XENLA Q5XG49_XENLA --------------------------------QVAPQA---AIANVTFPFIKIGKGEGSI Q68F30_XENLA Q68F30_XENLA A-------------------------------APQAAI---ANATCPFIENEIGKGEGSI Q6DF22_XENTR Q6DF22_XENTR A-------------------------------APQAAI---SNATCPFIENEIGKSEGII MATCH CONSENSUS ????????????????????????????????????????????????????????????

HEM0_CHICK HEM0_CHICK AHRAAPELQEDVERPQIPA--VEVLEELLRDGGA-------------------------- Q86LZ7_BRALA Q86LZ7_BRALA ------------------------------------------------------------ Q9XYA5_MYXGL Q9XYA5_MYXGL VKKASLELEEDVQEMQALR--DEMAEGKTPVSPTVINIKQGNIAAEQPSLLRAVHDSGLG Q4S5J1_TETNG Q4S5J1_TETNG ------------------------------------------------------------ Q6EEC3_PRODO Q6EEC3_PRODO ------------------------------------------------------------ Q6EEC4_LATCH Q6EEC4_LATCH ------------------------------------------------------------ Q6DKE7_XENLA Q6DKE7_XENLA IRKASPETQEDVQKMQTMR--KDL-RGPLTKDSGAAKTTLQNNRSVLEKFQESVLHQRPA Q28HS9_XENTR Q28HS9_XENTR IRKASPETQEDVQKMQTMR---KDLRGPITKGAGEAKMTLQKNRSVLEKFQESVLHQRPA Q66JC7_XENTR Q66JC7_XENTR IRKASPETQEDVQKMQTMR---KDLRGPITKGAGEAKMTLQKNRSVLEKFQESVLHQRPA Q6EE56_XENLA Q6EE56_XENLA ------------------------------------------------------------ Q6PAZ6_XENLA Q6PAZ6_XENLA IRKASAETQEDVKKMQTMR----------KDLHGLLTKDSGAAKTTLEKLQESMLHQRPA HEM1_CHICK HEM1_CHICK FCKASLELQEDVKEMQVDRKGKEFAKIPTNSVVRNTEAEGEEQSGLLKKFKDIMLKQRPE HEM1_DELLE HEM1_DELLE FCKASLELQEDVQEMHAVR--EEVAQTSVNPSVISVKTDGGELSGLLKNFQDIMRKQRPE HEM1_MOUSE HEM1_MOUSE FRKASLELQEDVQEMHAVR--KEAAQSPVPPSLVNVKTDGEDPSRLLKNFQDIMRKQRPE Q3V0B2_MOUSE Q3V0B2_MOUSE FRKASLELQEDVQEMHAVR--KEAAQSPVPPSLVNVKTDGEDPSRLLKNFQDIMRKQRPE HEM1_RAT HEM1_RAT FRKASLELQEDVQEMHAVR--KEVAQSPVLPSLVNAKRDGEGPSPLLKNFQDIMRKQRPE Q4R6D0_MACFA Q4R6D0_MACFA FCKASLELQEDVQEMNAVR--KEVAETSASPSVVSVKTDGGDPSGLLKNFQDIMQKQRPE HEM1_PONAB HEM1_PONAB FCKASLELQEDVQEMNAVR--KEVAETSGGPSVVSVKTDGGDPSGLLKNFQDIMQKQRPE B4DVA0_HUMAN B4DVA0_HUMAN FCKASLELQEDVQEMNAVR--KEVAETSAGPSVVSVKTDGGDPSGLLKNFQDIMQKQRPE HEM1_HUMAN HEM1_HUMAN FCKASLELQEDVQEMNAVR--KEVAETSAGPSVVSVKTDGGDPSGLLKNFQDIMQKQRPE Q5JAM2_HUMAN Q5JAM2_HUMAN FCKASLELQEDVQEMNAVR--KEVAETSAGPSVVSVKTDGGDPSGLLKNFQDIMQKQRPE B4DDG9_HUMAN B4DDG9_HUMAN FCKASLELQEDVQEMNAVR--KEVAETSAGPSVVSVKTDGGDPSGLLKNFQDIMQKQRPE HEM1_BOVIN HEM1_BOVIN FRKASLALQEDVQEMHAVR--EEVAQTSVNPSVINVKTEGGELNGLLKNFQDIMRKQRPE Q401C4_CAPHI Q401C4_CAPHI ------------------------------------------------------------ Q7T2F0_DANRE Q7T2F0_DANRE VRQASMALQEDVSEVRTVQ-------KDVSASALTPLKDGMNGGNLMKKLMKQRPA---- B5X2H2_SALSA B5X2H2_SALSA VRQASIQLQEDVQEVRTVQ--KDVTPAQALASSSSSKSGGLTRTDLMKKLLNQRPT---- HEM1_OPSTA HEM1_OPSTA VRQVGVEFQEDVEEIRTVQKEVSPAQLEQPSLIGKTMGEEGHQKNLMKSLLKQRPK---- Q4RX09_TETNG Q4RX09_TETNG VRQVGMEFQEDVQEVRTVQ--KGSYFQSHQCLYGVFTGSGDRGTNLMKVLLNQRPK---- HEM0_BOVIN HEM0_BOVIN VQKAAPEVQEDVKTFKTDL--PTSLASTSLKKTFSSPQEPEKNSE--------------- HEM0_DELLE HEM0_DELLE VQKAAPEVQEDVKTFKTDL--PISLASTSLRKPFFSPQEPEKNSE--------------- HEM0_RAT HEM0_RAT VQRAAPEVQEDVKTFKTDL--LSFMESTTRSQSVPRFQDPEQTGG--------------- Q642C1_RAT Q642C1_RAT VQRAAPEVQEDVKTFKTDL--LSFMESTTRSQSVPRFQDPEQTGG--------------- Q8R1G3_MOUSE Q8R1G3_MOUSE ------------------------------------------------------------ Q3TNI1_MOUSE Q3TNI1_MOUSE VQRAAPEVQEDVKTFKTDL--LSTMDSTTRSHSFPSFQEPEQTEG--------------- Q3TA47_MOUSE Q3TA47_MOUSE VQRAAPEVQEDVKTFKTDL--LSTMDSTTRSHSFPSFQEPEQTEG--------------- A2AFM1_MOUSE A2AFM1_MOUSE VQRAAPEVQEDVKTFKTDL--LSTMDSTTRSHSFPSFQEPEQTEG--------------- A2AFM0_MOUSE A2AFM0_MOUSE VQRAAPEVQEDVKTFKTDL--LSTMDSTTRSHSFPSFQEPEQTEG--------------- HEM0_MOUSE HEM0_MOUSE VQRAAPEVQEDVKTFKTDL--LSTMDSTTRSHSFPSFQEPEQTEG--------------- Q9DDC3_PLAFE Q9DDC3_PLAFE ------------------------------------------------------------ B7ZB88_HUMAN B7ZB88_HUMAN VQKAAPEVQEDVKAFKTDL----------------------------------------- HEM0_PONAB HEM0_PONAB VQKAAPEVQEDVKAFKTDL--PSSLVSASLKKPFSSPQEQEQISG--------------- A8K3F0_HUMAN A8K3F0_HUMAN VQKAAPEVQEDVKAFKTDL--PSSLVSVSLRKPFSGPQEQEQISG--------------- HEM0_HUMAN HEM0_HUMAN VQKAAPEVQEDVKAFKTDL--PSSLVSVSLRKPFSGPQEQEQISG--------------- A8K6C4_HUMAN A8K6C4_HUMAN VQKAAPEVQEDVKAFKT------------------------------------------- Q8N6H3_HUMAN Q8N6H3_HUMAN VQKAAPEVQEDVKAFKT------------------------------------------- Q5JZF5_HUMAN Q5JZF5_HUMAN VQKAAPEVQEDVKAFKT------------------------------------------- HEM0_DANRE HEM0_DANRE LVKASPQVQEDVQPNLENQ--DTSGLISSLFSGLQSHQST-------------------- Q4SYE6_TETNG Q4SYE6_TETNG MVHASPEVQEDIKK---GL--IGSALKVLKDGNLPGSVHAT------------------- HEM0_OPSTA HEM0_OPSTA MVRASPEVQEDVQADLKSP--VLPTPPQT------------------------------- Q6I749_ORYLA Q6I749_ORYLA ------------------------------------------------------------ Q6EEC2_LATCH Q6EEC2_LATCH ------------------------------------------------------------ Q6EEC1_PRODO Q6EEC1_PRODO ------------------------------------------------------------ Q5XG49_XENLA Q5XG49_XENLA VQRAAPQVQEDISAFQKDA--FSSLLIEVQSSLKKKFLAPSPKKVNLGTGAPL------- Q68F30_XENLA Q68F30_XENLA VQRAGPQVQEDISAFKTDA--LSSLLIEVQSSLKKKFLTPSSKKVNLGTGAPL------- Q6DF22_XENTR Q6DF22_XENTR VQRAGPQVQEDISAFKTDA--LSSLLIEVQSSLKKKFLAPPKKVNLGTGAPL-------- MATCH CONSENSUS ?????????ED?????????????????????????????????????????????????

HEM0_CHICK HEM0_CHICK ------------ALNRTVRDCMDED--AFPYEEQFQAQLGALRRTHTYRVVTAVGRRADA Q86LZ7_BRALA Q86LZ7_BRALA -------------------------------------------------VFKRVNRRA-P Q9XYA5_MYXGL Q9XYA5_MYXGL RRPTFSGPRSQSKTTHSLRDNMPSDGPIFDYDKFFDKKIEDKLEDHSYRIFKTVNRRADA Q4S5J1_TETNG Q4S5J1_TETNG ----------------------------FKYDEFFEKLIESRKREHTYRVFKTLNRCALS Q6EEC3_PRODO Q6EEC3_PRODO ----------------------------------------------------TVNRRADC Q6EEC4_LATCH Q6EEC4_LATCH ----------------------------------------------------TVNRRADS Q6DKE7_XENLA Q6DKE7_XENLA ------------IVSHLLQDNMPKAVQTFKYDKFFEKKIEEKKNDHTYRVFKTVNRRAEV Q28HS9_XENTR Q28HS9_XENTR ------------VVSHLLQDNMPKAVKTFKYDKFFEKKIDEKKNDHTYRVFKTVNRRAEV Q66JC7_XENTR Q66JC7_XENTR ------------VVSHLLQDNMPKAVKTFKYDKFFEKKIDEKKNDHTYRVFKTVNRRAEV Q6EE56_XENLA Q6EE56_XENLA ------------------------------------------------------------ Q6PAZ6_XENLA Q6PAZ6_XENLA ------------VVSHLLQDNMPKAVQTFKYDTFFEKKIEEKKNDHTYRVFKTVNRRAEV HEM1_CHICK HEM1_CHICK ------------SVSHLLQDNLPKSVSTFQYDQFFEKKIDEKKKDHTYRVFKTVNRKAQI HEM1_DELLE HEM1_DELLE ------------GVSHLLQDNLPKSVSTFQYDHFFEKKIDEKKNDHTYRVFKTVNRRAQF HEM1_MOUSE HEM1_MOUSE ------------RVSHLLQDNLPKSVSTFQYDHFFEKKIDEKKNDHTYRVFKTVNRRAQI Q3V0B2_MOUSE Q3V0B2_MOUSE ------------RVSHLLQDNLPKSVSTFQYDHFFEKKIDEKKNDHTYRVFKTVNRRAQI HEM1_RAT HEM1_RAT ------------RVSHLLQDNLPKSVSTFQYDHFFEKKIDEKKNDHTYRVFKTVNRRAQI Q4R6D0_MACFA Q4R6D0_MACFA ------------RVSHLLQDNLPKSVSTFQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHI HEM1_PONAB HEM1_PONAB ------------RVSHLLQDDLPKSVSTFQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHI B4DVA0_HUMAN B4DVA0_HUMAN ------------RVSHLLQDNLPKSVSTFQYGRFFEKKIDEKKNDHTYRVFKTVNRRAHI HEM1_HUMAN HEM1_HUMAN ------------RVSHLLQDNLPKSVSTFQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHI Q5JAM2_HUMAN Q5JAM2_HUMAN ------------RVSHLLQDNLPKSVSTFQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHI B4DDG9_HUMAN B4DDG9_HUMAN ------------RVSHLLQDNLPKSVSTFQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHI HEM1_BOVIN HEM1_BOVIN ------------RVSHLLQDNLPKSVCTFQYDRFFEKKIDEKKNDHSYRVFKTVNRKAQC Q401C4_CAPHI Q401C4_CAPHI ------------------------------------------------------------ Q7T2F0_DANRE Q7T2F0_DANRE ------------HVSHLLQDNMPKNVSSFRYDEFFEKKIEEKKSDHTYRVFKTVNRRATE B5X2H2_SALSA B5X2H2_SALSA ------------RVSHLLQENMPSF-SNFRYDEFFERKIEEKKSDHTYRVFKTVNRRATD HEM1_OPSTA HEM1_OPSTA ------------RVSHLLQDNLPGSFTRFYYDNFFEKKIEEKKSDHTYRVFKTVNRLANE Q4RX09_TETNG Q4RX09_TETNG ------------KVSHLLKDNLPGNMSCYKYDDFLEKKIVEKKSDHTYRVFKTVNRLASE HEM0_BOVIN HEM0_BOVIN ------------KVTHLIQNNMAGD-HVFGYDQFFRDKIMEKKQDHTYRVFKTVNRWADA HEM0_DELLE HEM0_DELLE ------------KVTHLIQNNMAGN-HVFGYDQFFRNKIMEKKQDHTYRVFKTVNRWADA HEM0_RAT HEM0_RAT ------------APPLLIQNNMTGS-QAFGYDQFFRDKIMEKKQDHTYRVFKTVNRWANA Q642C1_RAT Q642C1_RAT ------------VPPLLIQNNMTGS-QAFGYDQFFRDKIMEKKQDHTYRVFKTVNRWANA Q8R1G3_MOUSE Q8R1G3_MOUSE ------------------------------------------------------------ Q3TNI1_MOUSE Q3TNI1_MOUSE ------------AVPHLIQNNMTGS-QAFGYDQFFRDKIMEKKQDHTYRVFKTVNRWANA Q3TA47_MOUSE Q3TA47_MOUSE ------------AVPHLIQNNMTGS-QAFGYDQFFRDKIMEKEQDHTYRVFKTVNRWANA A2AFM1_MOUSE A2AFM1_MOUSE ------------AVPHLIQNNMTGS-QAFGYDQFFRDKIMEKKQDHTYRVFKTVNRWANA A2AFM0_MOUSE A2AFM0_MOUSE ------------AVPHLIQNNMTGS-QAFGYDQFFRDKIMEKKQDHTYRVFKTVNRWANA HEM0_MOUSE HEM0_MOUSE ------------AVPHLIQNNMTGS-QAFGYDQFFRDKIMEKKQDHTYRVFKTVNRWANA Q9DDC3_PLAFE Q9DDC3_PLAFE ------------------------------------------------------------ B7ZB88_HUMAN B7ZB88_HUMAN ------------------------------------------------------------ HEM0_PONAB HEM0_PONAB ------------KVTHLIQDNMPGN-YVFSYDQFFRDKIMEKKQDHTYRVFKTVNRWADA A8K3F0_HUMAN A8K3F0_HUMAN ------------KVTHLIQNNMPGN-YVFSYDQFFRDKIMEKKQDHTYRVFKTVNRWADA HEM0_HUMAN HEM0_HUMAN ------------KVTHLIQNNMPGN-YVFSYDQFFRDKIMEKKQDHTYRVFKTVNRWADA A8K6C4_HUMAN A8K6C4_HUMAN -----------------------GN-YVFSYDQFFRDKIMEKKQDHTYRVFKTVNRWADA Q8N6H3_HUMAN Q8N6H3_HUMAN -----------------------GN-YVFSYDQFFRDKIMEKKQDHTYRVFKTVNRWADA Q5JZF5_HUMAN Q5JZF5_HUMAN -----------------------GN-YVFSYDQFFRDKIMEKKQDHTYRVFKTVNRWADA HEM0_DANRE HEM0_DANRE ------------GPTHLLQDNFNRP--TFSYDEFFTQKIVEKKKDHTYRIFKTVNRFAEV Q4SYE6_TETNG Q4SYE6_TETNG ------------SVTHLLRDNMVGA--SFDYDAFFMEKLGEKKQDHTYRVFKTINRSAQA HEM0_OPSTA HEM0_OPSTA ------------GITQLLKDNMVGP--SFDYDNFFNEKIAEKKRDHTYRVFKTVNRNAVV Q6I749_ORYLA Q6I749_ORYLA ------------------------------------------------------------ Q6EEC2_LATCH Q6EEC2_LATCH -------------------------------------------------VFKTVNRCADS Q6EEC1_PRODO Q6EEC1_PRODO -------------------------------------------------VFKTVNRRADA Q5XG49_XENLA Q5XG49_XENLA ------------IPTHLIKENMTGK--TFGYDDFFSRRIEEKKSDHTYRVFKTVNRRADA Q68F30_XENLA Q68F30_XENLA ------------IPTHLIKENISGR-AAFGYDDFFSRRIEEKKSDHTYRVFKTVNRRADA Q6DF22_XENTR Q6DF22_XENTR ------------IPTHLIKENMTGR-AAFGYDDFFSRRIEEKKSDHTYRLFKTVNRRADA MATCH CONSENSUS ??????????????????????????????Y??????????????H?YRVFKTVNR?A??

HEM0_CHICK HEM0_CHICK PPLG---TRGTAPHTSVELWCSSDYLGLSRHPAVLRAARAALDAHGLGAGGTRNIGGTSP Q86LZ7_BRALA Q86LZ7_BRALA FPFAENYSEGCQPGEDVSVWCSNDYLGMSRHPKVVETIVDTVNRRGAGAGGTRNISGTSM Q9XYA5_MYXGL Q9XYA5_MYXGL FPFARNYSDSLYEAKQVSVWCSNDYLGMGRHPRVINTIMDTLKMYGAGAGGTRNISGTSR Q4S5J1_TETNG Q4S5J1_TETNG FPMADSYTDSFQA-KEVSVWCSNDYLGMSRHPRVTQAIMETLRKHGAGAGGTRNISGTSR Q6EEC3_PRODO Q6EEC3_PRODO FPLADDYSDSLVTKXEVSVWCSNDYLGMSRHPRVGAAIVETLKNHGSGAGGTRNISGTSR Q6EEC4_LATCH Q6EEC4_LATCH FPMADDYSSSLVTRKEVSVWCSNDYLGMSRHPRVVGAILENLKKHGAGAGGTRNISGTSK Q6DKE7_XENLA Q6DKE7_XENLA FPMADDYSDTLISKKTVSVWCSNDYLGMSRHPKVVGAVMETLKEHGAGAGGTRNISGTSK Q28HS9_XENTR Q28HS9_XENTR FPMADDYSDTLISKKTVSVWCSNDYLGMSRHPKVVGAVMETLKQHGAGAGGTRNISGTSK Q66JC7_XENTR Q66JC7_XENTR FPMADDYSDTLISKKTVSVWCSNDYLGMSRHPKVVGAVMETLKQHGAGAGGTRNISGTSK Q6EE56_XENLA Q6EE56_XENLA ---------TLISKXTVSVWCSNDYLGMSRHPKVAGAVMETLKQHGAGAGGTRNISGTSK Q6PAZ6_XENLA Q6PAZ6_XENLA FPMADDYSDTLISKKTVSVWCSNDYLGMSRHPKVAGAVMETLKQHGAGAGGTRNISGTSK HEM1_CHICK HEM1_CHICK FPMADDYSDSLITKKEVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSK HEM1_DELLE HEM1_DELLE FPMADDYSDSLVTKKQVSVWCSNDYLGMSCHPRVCGAVMDTLKQHGTGAGGTRNISGTSK HEM1_MOUSE HEM1_MOUSE FPMADDYTDSLITKKQVSVWCSNDYLGMSRHPRVCGAVMETVKQHGAGAGGTRNISGTSK Q3V0B2_MOUSE Q3V0B2_MOUSE FPMADDYTDSLITKKQVSVWCSNDYLGMSRHPRVCGAVMETVKQHGAGAGGTRNISGTSK HEM1_RAT HEM1_RAT FPMADDYTDSLITKKQVSVWCSNDYLGMSRHPRVCGAVIETVKQHGAGAGGTRNISGTSK Q4R6D0_MACFA Q4R6D0_MACFA FPMADDYSDSLITKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSK HEM1_PONAB HEM1_PONAB FPMADDYSDSLITKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSK B4DVA0_HUMAN B4DVA0_HUMAN FPMADDYSDSLITKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSK HEM1_HUMAN HEM1_HUMAN FPMADDYSDSLITKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSK Q5JAM2_HUMAN Q5JAM2_HUMAN FPMADDYSDSLITKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSK B4DDG9_HUMAN B4DDG9_HUMAN FPMADDYSDSLITKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSK HEM1_BOVIN HEM1_BOVIN FPMADDYSDSLISKKQVSVWCSNDYLGMSRHPRVCGAVIDTLKQHGTGAGGTRNISGTSK Q401C4_CAPHI Q401C4_CAPHI ------------------------------------------------------------ Q7T2F0_DANRE Q7T2F0_DANRE FPMADDYTESLSFKRNVSVWCSNDYLGMSRHPRVVQTIMDTLGKHGSGAGGTRNISGTSK B5X2H2_SALSA B5X2H2_SALSA FPMGDDYTDSLSDRRDVSVWCSNDYLGMSRHPRVVHSITETLRKHGSGAGGTRNISGTSK HEM1_OPSTA HEM1_OPSTA FPMADDFTGSLEDKREVSVWCSNDYLGMSRHPRVAQAIMETLRKHGSGAGGTRNISGTSK Q4RX09_TETNG Q4RX09_TETNG FPMADDFTSSLEDRREVSVWCSNDYLGMSRHPRVMQAIMDTLRKHGSGAGGTRNISGTSK HEM0_BOVIN HEM0_BOVIN YPFAEHFFEASVASKDVSVWCSNDYLGMSRHPRVLQATQEILQRHGAGAGGTRNISGTSK HEM0_DELLE HEM0_DELLE YPFAEHFFEASVASKDVSVWCSNDYLGMSRHPRVLQATQETLQRHGAGAGGTRNISGTSR HEM0_RAT HEM0_RAT YPFAQHFSEASMDSKDVSVWCSNDYLGISRHPRVLQAIEETLKNHGAGAGGTRNISGTSK Q642C1_RAT Q642C1_RAT YPFAQHFSEASMDSKDVSVWCSNDYLGISRHPRVLQAIEETLKNHGAGAGGTRNISGTSK Q8R1G3_MOUSE Q8R1G3_MOUSE -----------MASKDVSVWCSNDYLGISRHPRVLQAIEETLKNHGAGAGGTRNISGTSK Q3TNI1_MOUSE Q3TNI1_MOUSE YPFAQHFSEASMASKDVSVWCSNDYLGISRHPRVLQAIEETLKNHGAGAGGTRNISGTSK Q3TA47_MOUSE Q3TA47_MOUSE YPFAQHFSEASMASKDVSVWCSNDYLGISRHPRVLQAIEETLKNHGAGAGGTRNISGTSK A2AFM1_MOUSE A2AFM1_MOUSE YPFAQHFSEASMASKDVSVWCSNDYLGISRHPRVLQAIEETLKNHGAGAGGTRNISGTSK A2AFM0_MOUSE A2AFM0_MOUSE YPFAQHFSEASMASKDVSVWCSNDYLGISRHPRVLQAIEETLKNHGAGAGGTRNISGTSK HEM0_MOUSE HEM0_MOUSE YPFAQHFSEASMASKDVSVWCSNDYLGISRHPRVLQAIEETLKNHGAGAGGTRNISGTSK Q9DDC3_PLAFE Q9DDC3_PLAFE ------------------------------------------------------------ B7ZB88_HUMAN B7ZB88_HUMAN -------------------------------PSSLVSV--SLRKPFSGPQEQEQISG--- HEM0_PONAB HEM0_PONAB YPFAQHFSEASVASKDVSVWCSNDYLGMSRHPQVLRATQETLQRHGAGAGGTRNISGTSK A8K3F0_HUMAN A8K3F0_HUMAN YPFAQHFSEASVASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGAGAGGTRNISGTSK HEM0_HUMAN HEM0_HUMAN YPFAQHFSEASVASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGAGAGGTRNISGTSK A8K6C4_HUMAN A8K6C4_HUMAN YPFAQHFSEASVASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGAGAGGTRNISGTSK Q8N6H3_HUMAN Q8N6H3_HUMAN YPFAQHFSEASVASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGVGAGGTRNISGTSK Q5JZF5_HUMAN Q5JZF5_HUMAN YPFAQHFSEASVASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGAGAGGTRNISGTSK HEM0_DANRE HEM0_DANRE FPFAEDYSIAGRLGSQVSVWCSNDYLGMSRHPRVVKAIGDALKKHGAGAGGTRNISGTSN Q4SYE6_TETNG Q4SYE6_TETNG FPFAEDYSVPGRDASQVSVWCSNDYLGMSQHPRVITAIRDTLDRHGAGAGGTRNISGTSN HEM0_OPSTA HEM0_OPSTA FPFAEDYSVSDRQGSQVSVWCSNDYLGMSRHPRVLEAIREVLERHGAGAGGTRNISGTSK Q6I749_ORYLA Q6I749_ORYLA ---------------------------MSRHPKVLGAIREALENYGAGAGGTRNISGTSN Q6EEC2_LATCH Q6EEC2_LATCH FPFAEDHSGSRVAKKEVSVWCSNDYLGMSRHPRVIQAIRDAQTLHGAGAGGTRNISGTSK Q6EEC1_PRODO Q6EEC1_PRODO FPYGEDYSESLNRKKEVSVWCSNDYLGMSRHPRVLQAISDTLQQYGAGAGGTRNISGTSK Q5XG49_XENLA Q5XG49_XENLA YPFAEDYSDLHGEKKEVSVWCSNDYLGMSQHPKVLKAILEALQEHGAGAGGTRNISGTSK Q68F30_XENLA Q68F30_XENLA YPFAEDYSDLHGEKKEVSVWCSNDYLGMSRHPRVLKAISEALQEHGAGAGGTRNISGTSK Q6DF22_XENTR Q6DF22_XENTR YPFAEDYSDLHGEKKEVSVWCSNDYLGMSRHPKVLKAIAEALEEHGAGAGGTRNISGTSK MATCH CONSENSUS ?P?A????????????VSVWCSNDYLG?SRHP?V??A????L??HG?GAGGTRNISGTS?

HEM0_CHICK HEM0_CHICK LHGALERALALLHRQPRAALFSSCFAANDTALDTLARILPGCQVYSDAGNHASMIQGIRR Q86LZ7_BRALA Q86LZ7_BRALA YHVDLENELADLHQKEAALLFTSCYVANDSTLFTLARALPGCEIYPDAGNHASMIQGIKN Q9XYA5_MYXGL Q9XYA5_MYXGL FHVALEQELADLHAKDAALVFSSCFVANDSTLFTLAKMLPGCEFYSDAGNHASMIQGIRN Q4S5J1_TETNG Q4S5J1_TETNG FHVELEYELADLHSKDAALLFSSCFVANDSTLFTLARMLPGCEVYSDAGNHASMIQGVRN Q6EEC3_PRODO Q6EEC3_PRODO FHVELEHELADLHGKDAALLFSSCFVANDSTLFTLAKMLPGCEIYSDAGNHASMIQGIRN Q6EEC4_LATCH Q6EEC4_LATCH FHVRLEQELADLHGKDAALLFSSCFVANDSTLFTLAKMLPGCEIYSDAGNHASMIQGIRN Q6DKE7_XENLA Q6DKE7_XENLA FHVDLEHELADLHGKDAALLFSSCFVANDSTLFTLAKMLPGCEIYSDAGNHASMIQGIRN Q28HS9_XENTR Q28HS9_XENTR FHVELEHELADLHGKDAALLFSSCFVANDSTLFTLAKMLPGCEIYSDAGNHASMIQGIRN Q66JC7_XENTR Q66JC7_XENTR FHVELEHELADLHGKDAALLFSSCFVANDSTLFTLAKMLPGCEIYSDAGNHASMIQGIRN Q6EE56_XENLA Q6EE56_XENLA FHVDLEHELADLHGKDAALLFSSCFVANDATLFTLAKMLPGCEIYSDAGNHASMIQGIRN Q6PAZ6_XENLA Q6PAZ6_XENLA FHVDLEHELADLHGKDAALLFSSCFVANDATLFTLAKMLPGCEIYSDAGNHASMIQGIRN HEM1_CHICK HEM1_CHICK FHVDLEKELADLHGKDAALLFSSCFVANDSTLFTLAKMLPGCEIYSDSGNHASMIQGIRN HEM1_DELLE HEM1_DELLE FHVDLEQELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIWN HEM1_MOUSE HEM1_MOUSE FHVELEQALADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRN Q3V0B2_MOUSE Q3V0B2_MOUSE FHVELEQALADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRN HEM1_RAT HEM1_RAT FHVELEQELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRN Q4R6D0_MACFA Q4R6D0_MACFA FHVDLEQELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRN HEM1_PONAB HEM1_PONAB FHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRN B4DVA0_HUMAN B4DVA0_HUMAN FHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRN HEM1_HUMAN HEM1_HUMAN FHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRN Q5JAM2_HUMAN Q5JAM2_HUMAN FHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRN B4DDG9_HUMAN B4DDG9_HUMAN FHVDLERELADLHGKDAALLFSSCF----------------------------------- HEM1_BOVIN HEM1_BOVIN FHVDLEQELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDAGNHASMIQGIRN Q401C4_CAPHI Q401C4_CAPHI ----------------------------------------------------------RN Q7T2F0_DANRE Q7T2F0_DANRE FHVDLEHELADLHGKDAALLFTSCFVANDSTLFTLAKMMPGCEIYSDAGNHASMIQGIRN B5X2H2_SALSA B5X2H2_SALSA FHVELEQELADLHRKDAALLFTSCFVANDSTLFTLAKMIPGCEIYSDAGNHASMIQGIRN HEM1_OPSTA HEM1_OPSTA FHVELEQELADLHRKDAALLFTSCFVANDSTLFTLAKMLPGCEIYSDAGNHASMIQGIRN Q4RX09_TETNG Q4RX09_TETNG FHVELEHELADLHNKDAALLFTSCFVANDSTLFTLAKMLPGCEIYSDAGNHASMIQGIRN HEM0_BOVIN HEM0_BOVIN FHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRN HEM0_DELLE HEM0_DELLE FHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRN HEM0_RAT HEM0_RAT FHVELEQELAELHHKDSALLFSSCFVANDSTLFTLAKLLPGCEIYSDAGNHASMIQGIRN Q642C1_RAT Q642C1_RAT FHVELEQELAELHHKDSALLFSSCFVANDSTLFTLAKLLPGCEIYSDAGNHASMIQGIRN Q8R1G3_MOUSE Q8R1G3_MOUSE FHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKLLPGCEIYSDAGNHASMIQGIRN Q3TNI1_MOUSE Q3TNI1_MOUSE FHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKLLPGCEIYSDAGNHASMIQGIRN Q3TA47_MOUSE Q3TA47_MOUSE FHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKLLPGCEIYSDAGNHASMIQGIRN A2AFM1_MOUSE A2AFM1_MOUSE FHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKLLPGCEIYSDAGNHASMIQGIRN A2AFM0_MOUSE A2AFM0_MOUSE FHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKLLPGCEIYSDAGNHASMIQGIRN HEM0_MOUSE HEM0_MOUSE FHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKLLPGCEIYSDAGNHASMIQGIRN Q9DDC3_PLAFE Q9DDC3_PLAFE ----------------------------------LAKMLPGCEIYSDAGNHASMIIGIRN B7ZB88_HUMAN B7ZB88_HUMAN ------------------------------------------------------------ HEM0_PONAB HEM0_PONAB FHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRN A8K3F0_HUMAN A8K3F0_HUMAN FHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRN HEM0_HUMAN HEM0_HUMAN FHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRN A8K6C4_HUMAN A8K6C4_HUMAN FHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRN Q8N6H3_HUMAN Q8N6H3_HUMAN FHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRN Q5JZF5_HUMAN Q5JZF5_HUMAN FHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRN HEM0_DANRE HEM0_DANRE YHVALENELARLHQKDGALVFSSCFVANDSTLFTLAKMLPGCEIYSDMGNHASMIQGIRN Q4SYE6_TETNG Q4SYE6_TETNG YHVSLETELAQLHQKDAALVFSSCFVANDSTLFTLAKMLPGCEIYSDAGNHASMIQGIRN HEM0_OPSTA HEM0_OPSTA YHVTLEKELAHLHQKDAALVFSSCFVANDSTLFTLAKMLPGCHIYSDAGNHASMIQGIRN Q6I749_ORYLA Q6I749_ORYLA FHVALERELAQLHGKDAALVFSSCFVANDSTLFTLAKMLPGCEIYSDAGNHASMIQGIRN Q6EEC2_LATCH Q6EEC2_LATCH FHVDLEKELASLHQKDAALLFSSCFVANDSTLFTLARMLPGCEIYSDAGNHASMIQGIRN Q6EEC1_PRODO Q6EEC1_PRODO FHVDLEEELADLHQKDGALLFSSCFVANDSTLFTLSKMLPGCEIYSDAGNHASMIQGVRN Q5XG49_XENLA Q5XG49_XENLA YHVDLECELADLHNKDAALLFSSCFVANDSALFTLAKMLPGCEIYSDAGNHASMIQGIRN Q68F30_XENLA Q68F30_XENLA YHVDLECELADLHNKDAALLFSSCFVANDSALFTLAKMLPGCEIYSDAGNHASMIQGIRN Q6DF22_XENTR Q6DF22_XENTR YHVDLECELADLHNKDAALLFSSCFVANDSTLFTLAKMLPGCEIYSDAGNHASMIQGIRN MATCH CONSENSUS FHV?LE?ELA?LH?KD?ALLFSSCFVANDSTLFTLAK??PGCEIYSD?GNHASMIQGIRN

HEM0_CHICK HEM0_CHICK RGVPKFIFRHNDPHHLEQLLGRSPPGVPKIVAFESLHSMDGSIAPLEELCDVAHAYGALT Q86LZ7_BRALA Q86LZ7_BRALA SGQPKFIFKHNDPIHLEELLKKSDPATPKIVAFETVHSMDGAVCPLDELCDVAHKYGAIT Q9XYA5_MYXGL Q9XYA5_MYXGL SGVPKFIFRHNDAAHLDELLSRSDPSTPKIVAFETVHSMDGAICPLEELCDVSXKYGAIT Q4S5J1_TETNG Q4S5J1_TETNG SAARKFIFRHNDVGHLHQLLEKSDPSAPKIVAFETVHSMTGAVCPLEEMCDVAHKFGAIT Q6EEC3_PRODO Q6EEC3_PRODO SQIPKYIFRHNDADHLRELLAKSNPSTPKIVAFETVHSMDGAICSLEEMCDIAHEYGVIT Q6EEC4_LATCH Q6EEC4_LATCH SRVPKMIFRHNDVNHLRELLKKSNPSTPKIVAFETVHSMDGAVCPSEEMCDVAHEYGAIT Q6DKE7_XENLA Q6DKE7_XENLA SRVPKYVFRHNDVGHLRELLKNSDPSIPKIVAFETVHSMDGAVCPLEEMCDVAHEYGAIT Q28HS9_XENTR Q28HS9_XENTR SRAPKYVFRHNDVGHLRELLKNSDPSTPKIVAFETVHSMDGAVCPLEEMCDVAHEYGAIT Q66JC7_XENTR Q66JC7_XENTR SRAPKYVFRHNDVGHLRELLKNSDPSTPKIVAFETVHSMDGAVCPLEEMCDVSHEYGAIT Q6EE56_XENLA Q6EE56_XENLA SRVPKYVFRHNDVGHLCELLKNSDPSTPKIVAFETVHSMDGAVCPLEEMCDVAHEYGAIT Q6PAZ6_XENLA Q6PAZ6_XENLA SRVPKYVFRHNDVGHLRELLKNSDPSTPKIVAFETVHSMDGAVCPLEEMCDVAHEYGAIT HEM1_CHICK HEM1_CHICK SRVPKHIFRHNDVNHLRELLKKSDPSTPKIVAFETVHSMDGAVCPLEELCDVAHEHGAIT HEM1_DELLE HEM1_DELLE SRVPKYIYRHNDVDHLRELLQRSDPAVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAIT HEM1_MOUSE HEM1_MOUSE SRVPKYIFRHNDVNHLRELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAIT Q3V0B2_MOUSE Q3V0B2_MOUSE SRVPKYIFRHNDVNHLRELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAIT HEM1_RAT HEM1_RAT SRVPKYIFRHNDVNHLRELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAIT Q4R6D0_MACFA Q4R6D0_MACFA SRVPKYIFRHNDVSHLRELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCGVAHEFGAIT HEM1_PONAB HEM1_PONAB SRVPKYIFRHNDVSHLRELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAIT B4DVA0_HUMAN B4DVA0_HUMAN SRVPKYIFRHNDVSHLRELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAIT HEM1_HUMAN HEM1_HUMAN SRVPKYIFRHNDVSHLRELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAIT Q5JAM2_HUMAN Q5JAM2_HUMAN SRVPKYIFRHNDVSHLRELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAIT B4DDG9_HUMAN B4DDG9_HUMAN ---------------------------------------------------VAHEFGAIT HEM1_BOVIN HEM1_BOVIN SGVPKYIFRHNDVSHLRELLQRSDPAVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAIT Q401C4_CAPHI Q401C4_CAPHI SRVPKYIFRHNDVNHLRELLQRSDPAVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAIT Q7T2F0_DANRE Q7T2F0_DANRE SGAKKFIFRHNDAKHLRELLEKSDPSTPKIVAFETVHSMDGAVCPLEQLCDVAHEFGAVT B5X2H2_SALSA B5X2H2_SALSA SGAKKFVFRHNDPDHLRELLLKSDPTAPKIVAFETVHSMDGAVCPLEELCDVAHEFGAIT HEM1_OPSTA HEM1_OPSTA SGAKKFIFRHNDVAHLRELLEKGDPTKPKIVAFETVHSMDGAVCPLEEMCDLAHEFGAIT Q4RX09_TETNG Q4RX09_TETNG SGAKKFIFRHNDVGHLRELLQKGDPTKPKIVAFETVHSMDGAVCPLEEMCDTAHEFGAIT HEM0_BOVIN HEM0_BOVIN SGAAKFVFRHNDPDHLKKLLKKSNPETPKIVAFETVHSMDGAICPLEELCDVAHQYGALT HEM0_DELLE HEM0_DELLE SGAAKFVFRHNDPDHLKKLLKKSNPETPKIVAFETVHSMDGAICPLEELCDVAHQYGALT HEM0_RAT HEM0_RAT SGAVKFVFRHNDPGHLKKLLEKSDPKTPKIVAFETVHSMDGAICPLEELCDVAHQYGALT Q642C1_RAT Q642C1_RAT SGAVKFVFRHNDPGHLKKLLEKSDPKTPKIVAFETVHSMDGAICPLEELCDVAHQYGALT Q8R1G3_MOUSE Q8R1G3_MOUSE SGAAKFVFRHNDPGHLKKLLEKSDPKTPKIVAFETVHSMDGAICPLEELCDVAHQYGALT Q3TNI1_MOUSE Q3TNI1_MOUSE SGAAKFVFRHNDPGHLKKLLEKSDPKTPKIVAFETVHSMDGAICPLEELCDVAHQYGALT Q3TA47_MOUSE Q3TA47_MOUSE SGAAKFVFRHNDPGHLKKLLEKSDPKTPKIVAFETVHSMDGAICPLEELCDVAHQYGALT A2AFM1_MOUSE A2AFM1_MOUSE SGAAKFVFRHNDPGHLKKLLEKSDPKTPKIVAFETVHSMDGAICPLEELCDVAHQYGALT A2AFM0_MOUSE A2AFM0_MOUSE SGAAKFVFRHNDPGHLKKLLEKSDPKTPKIVAFETVHSMDGAICPLEELCDVAHQYGALT HEM0_MOUSE HEM0_MOUSE SGAAKFVFRHNDPGHLKKLLEKSDPKTPKIVAFETVHSMDGAICPLEELCDVAHQYGALT Q9DDC3_PLAFE Q9DDC3_PLAFE SGAKKFIFRHNDVADLRRLLQKGDPSKPKIVAFETVHSMDGAVCSLEEMCDVAHEFGAIT B7ZB88_HUMAN B7ZB88_HUMAN --------------------------------------------------KVTHLIQNNM HEM0_PONAB HEM0_PONAB SGAAKFVFRHNDPDHLKKLLEKSNPKIPKIVAFEAVHSMDGAICPLEELCDVSHQYGALT A8K3F0_HUMAN A8K3F0_HUMAN SGAAKFVFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALT HEM0_HUMAN HEM0_HUMAN SGAAKFVFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALT A8K6C4_HUMAN A8K6C4_HUMAN SGAAKFVFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALT Q8N6H3_HUMAN Q8N6H3_HUMAN SGAAKFVFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALT Q5JZF5_HUMAN Q5JZF5_HUMAN SGAAKFVFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALT HEM0_DANRE HEM0_DANRE SGAKRFIFRHNDASHLEELLSRSDPLTPKIVAFETVHSMDGAICPLEELCDVAHKYGALT Q4SYE6_TETNG Q4SYE6_TETNG SGAKRFIFRHNDSKHLEELLQRADPKTPKIVAFETVHSMDGAICPLEELCDIAHRFGALT HEM0_OPSTA HEM0_OPSTA SGAKRFIFRHNDSRHLEELLQQSDPKTPKIVAFETVHSMDGAICPLEELCDVAHRHGALT Q6I749_ORYLA Q6I749_ORYLA SGAKRFIFRHNDRRHLEELLQRSDPKTPKIVAFETVHSMDGAICPLEELCDAAHRYGALT Q6EEC2_LATCH Q6EEC2_LATCH SGVPKFVFRHNDVQHLEQLLKNSDPRRPKIIAFETVHSMDGAICPLEEMCDVAHKYGGIT Q6EEC1_PRODO Q6EEC1_PRODO SGVPKYVFRHNDVEHLEQLLKKSDPKKPKIVAFETVHSMDGHICPLEEMCDVAHKYGAVT Q5XG49_XENLA Q5XG49_XENLA SGVTKFVFRHNDPAHLEELLQKADPKTPKIVAFETVHSMDGAICPLEEMCDVAHKYGALT Q68F30_XENLA Q68F30_XENLA SGVTKFVFRHNDPAHLEELLQKADPKTPKIVAFETVHSMDGAICPLEEMCDVAHKYGAMT Q6DF22_XENTR Q6DF22_XENTR SGVTKFVFRHNDPAHLEELLQKANPKTPKIVAFETVHSMDGAICPLEEVCDIAHKYGALT MATCH : CONSENSUS S???K??FRHND??HL??LL??S?P??PKIVAFETVHSMDGA?CPLEE?CDVAH??GA?T

HEM0_CHICK HEM0_CHICK FVDEVHAVGLYGARGAGIAERDGVQHKVDVVSGTLGKALGAVGGYIAGSEALVDAVRSLG Q86LZ7_BRALA Q86LZ7_BRALA FIDEVHAVGLYGTRGGGIGDRDGLLPKMDIISGTLGKAFGLIGGYIAGSSILVDMIRSYA Q9XYA5_MYXGL Q9XYA5_MYXGL FIDEVHAVGLYGARGGGIGDREGLMHKMDIISGTLGKAYGCVGGYVASTNTLVDTVRSYA Q4S5J1_TETNG Q4S5J1_TETNG FVDEVHAVGLYGPRGGGIGERDRVAHKMDVISGTLGKAYGCVGGYIASTTALVDTVRSYA Q6EEC3_PRODO Q6EEC3_PRODO FVDEVHAVGLYGPRGGGVGDRDGVMHKLDIISGTLGKAFGCVGGYIASTASLIDTVRSYA Q6EEC4_LATCH Q6EEC4_LATCH FVDEVHAVGLYGSRGGGIGDRDGIMHKMDIISGTLGKAFGCVGGYIASTAGLIDTVRSYA Q6DKE7_XENLA Q6DKE7_XENLA FVDEVHAVGLYGARGGGIGDRDGVMNKMDIISGTLGKAFGCVGGYVASTSALIDTIRSYA Q28HS9_XENTR Q28HS9_XENTR FVDEVHAVGLYGARGGGIGDRDGVMAKMDIISGTLGKAFGCVGGYIASTSALIDTVRSYA Q66JC7_XENTR Q66JC7_XENTR FVDEVHAVGLYGARGGGIGDRDGVMTKMDIISGTLGKAFGCVGGYIASTSALIDTVRSYA Q6EE56_XENLA Q6EE56_XENLA FVDEVHAVGLYGARGGGIGDQDGVMNKMDIVSGTLGKAFGCVGGYIASTSALIDTVRSYA Q6PAZ6_XENLA Q6PAZ6_XENLA FVDEVHAVGLYGARGGGIGDRDGVMNKMDIVSGTLGKAFGCVGGYIASTSALIDTVRSYA HEM1_CHICK HEM1_CHICK FVDEVHAVGLYGARGGGIGDRDGVMHKMDIISGTLGKAFACVGGYISSTSALIDTVRSYA HEM1_DELLE HEM1_DELLE FVDEVHAVGLYGAQGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSSLIDTIRSYA HEM1_MOUSE HEM1_MOUSE FVDEVHAVGLYGARGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSLLIDTVRSYA Q3V0B2_MOUSE Q3V0B2_MOUSE FVDEVHAVGLYGARGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSLLIDTVRSYA HEM1_RAT HEM1_RAT FVDEVHAVGLYGASGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSLLIDTVRSYA Q4R6D0_MACFA Q4R6D0_MACFA FVDEVHAVGLYGARGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSSLIDTVRSYA HEM1_PONAB HEM1_PONAB FVDEVHAVGLYGARGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSSLIDTVRSYA B4DVA0_HUMAN B4DVA0_HUMAN FVDEVHAVGLYGARGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSSLIDTVRSYA HEM1_HUMAN HEM1_HUMAN FVDEVHAVGLYGARGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSSLIDTVRSYA Q5JAM2_HUMAN Q5JAM2_HUMAN FVDEVHAVGLYGARGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSSLIDTVRSYA B4DDG9_HUMAN B4DDG9_HUMAN FVDEVHAVGLYGARGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSSLIDTVRSYA HEM1_BOVIN HEM1_BOVIN FVDEVHAVGLYGLQGGGIGDRDGVMPKMDIISGTLGKAIGCVGGYIASTSSLIDTVRSYA Q401C4_CAPHI Q401C4_CAPHI FVDEVHAVGLYGLQGGGIGDRDGVMPKMDIISGTLGKAIGCVGGYIASTSALIDTVRSYA Q7T2F0_DANRE Q7T2F0_DANRE FVDEVHAVGLYGPRGGGIGDRDSVMHKMDIISGTLGKAFGCVGGYIASTHALVDTVRSYA B5X2H2_SALSA B5X2H2_SALSA FVDEVHAVGLYGARGGGIGERDGIMHKMDIISGTLGKAFGCVGGYIASTDALVDTVRSYA HEM1_OPSTA HEM1_OPSTA FVDEVHAVGLYGPRGGGIGDRDGIMHKMDIISGTLGKAFGCVGGYIASTATLVDTVRSYA Q4RX09_TETNG Q4RX09_TETNG FVDEVHAVGLYGARGGGIGDRDGVMHKMDIISGTLGKAFGCVGGYIASTAALVDAMRSYA HEM0_BOVIN HEM0_BOVIN FVDEVHAVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYA HEM0_DELLE HEM0_DELLE FVDEVHAVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYA HEM0_RAT HEM0_RAT FVDEVHAVGLYGTRGAGIGERDGIMHKLDIISGTLGKAFGCVGGYIASTRDLVDMVRSYA Q642C1_RAT Q642C1_RAT FVDEVHAVGLYGTRGAGIGERDGIMHKLDIISGTLGKAFGCVGGYIASTRDLVDMVRSYA Q8R1G3_MOUSE Q8R1G3_MOUSE FVDEVHAVGLYGARGAGIGERDGIMHKLDIISGTLGKAFGCVGGYIASTRDLVDMVRSYA Q3TNI1_MOUSE Q3TNI1_MOUSE FVDEVHAVGLYGARGAGIGERDGIMHKLDIISGTLGKAFGCVGGYIASTRELVDMVRSYA Q3TA47_MOUSE Q3TA47_MOUSE FVDEVHAVGLYGARGAGIGERDGIMHKLDIISGTLGKAFGCVGGYIASTRDLVDMVRSYA A2AFM1_MOUSE A2AFM1_MOUSE FVDEVHAVGLYGARGAGIGERDGIMHKLDIISGTLGKAFGCVGGYIASTRDLVDMVRSYA A2AFM0_MOUSE A2AFM0_MOUSE FVDEVHAVGLYGARGAGIGERDGIMHKLDIISGTLGKAFGCVGGYIASTRDLVDMVRSYA HEM0_MOUSE HEM0_MOUSE FVDEVHAVGLYGARGAGIGERDGIMHKLDIISGTLGKAFGCVGGYIASTRDLVDMVRSYA Q9DDC3_PLAFE Q9DDC3_PLAFE FVDEVHAVGLYGPRGGGIGDRDGVMHKIDIVSGTLGKAFGCVGGYIASTSSLVDMVRSFA B7ZB88_HUMAN B7ZB88_HUMAN PGNYVFSYDQF-FRDKIMEKKQDHTYRVFKTVNRWADAYPFAQHFSEASVASKDVSVWCS HEM0_PONAB HEM0_PONAB FVDEVHAVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYA A8K3F0_HUMAN A8K3F0_HUMAN FVDEVHAVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYA HEM0_HUMAN HEM0_HUMAN FVDEVHAVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYA A8K6C4_HUMAN A8K6C4_HUMAN FVDEVHAVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYA Q8N6H3_HUMAN Q8N6H3_HUMAN FVDEVHAVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYA Q5JZF5_HUMAN Q5JZF5_HUMAN FVDEVHAVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYA HEM0_DANRE HEM0_DANRE FVDEVHAVGLYGAHGAGVGERDNVMHKIDIVSGTLGKAFGCVGGYIASTAALVDTVRSFA Q4SYE6_TETNG Q4SYE6_TETNG FVDEVHAVGLYGAHGAGVGERDNVMDKIDIVTGTLGKAFGCVGGYIASSAALVDTVRSYA HEM0_OPSTA HEM0_OPSTA FVDEVHAVGLYGAHGAGVGERDNVMHKIDIVSGTLGKAFGCVGGYVASSAALVDTVRSFA Q6I749_ORYLA Q6I749_ORYLA FVDEVHAVGLYGAHGAGVGERDNIMHKIDIVSGTLGKAFGCVGGYVASSGALVDTVRSYA Q6EEC2_LATCH Q6EEC2_LATCH FVDEVHAVGLYGAHGAGIGERDGVMHKIDIVSGTLGKAFGCVGGYIASTAALVDTVRSYA Q6EEC1_PRODO Q6EEC1_PRODO FVDEVHAVGLYGAHGAGVGERDGVMNKMDIISGTLGKAFGCVGGYIASTASLIDTVRSYA Q5XG49_XENLA Q5XG49_XENLA FVDEVHAVGLYGTHGAGVGERDGVMHKMDIISGTLGKAFGCVGGYIASTASLIDTVRSYA Q68F30_XENLA Q68F30_XENLA FVDEVHAVGLYGTHGAGVGERDGVMHKMDIISGTLGKAFGCVGGYIASTASLIDTVRSYA Q6DF22_XENTR Q6DF22_XENTR FVDEVHAVGLYGTHGAGVGERDSVMHKMDIISGTLGKAFGCVGGYVASTASLIDTVRSYA MATCH : *.: . : . : .:: :: . ..* : .: * . CONSENSUS FVDEVHAVGLYG??G?GIG?RDG?M?K?DIISGTLGKAFGCVGGYIAST??L?D?VRSYA

HEM0_CHICK HEM0_CHICK PGFIFTTALPPQRGGGALAALQVVGSAEG--AALRRAHQRHAKHLRVLLRDRGLPAL--P Q86LZ7_BRALA Q86LZ7_BRALA AGFIFTTALPPMVLAGALASVRILKSDEG--VQLRRGHQRAVKLMRTLLMDAGLPVVHCP Q9XYA5_MYXGL Q9XYA5_MYXGL AGFIFTTSLPPMVLAGARESVQVLKSAEG--RALRRAHQRNVIYLRQLLMDAGLPVIHCP Q4S5J1_TETNG Q4S5J1_TETNG TGFIFTTSLPPMLLAGAKESIGVLKGEEG--RALRLKHQRNVKLLRQMLMDSGLPVTSCH Q6EEC3_PRODO Q6EEC3_PRODO AGFIFTTSLPPMLLAGAIESVRIIKSEEG--RALRRQHQRNVKLMRQMLMDAGLPVVHCP Q6EEC4_LATCH Q6EEC4_LATCH AGFIFTTSLPPMILAGALEPVKTLKSEEG--HALRRKHQRNVKLMRQMLMDASLPVVNCP Q6DKE7_XENLA Q6DKE7_XENLA AGFIFTTSLPPMLLSGAIASVRVLKSEEG--QALRRQHQRNVKLMRQMLMDSGLPVVHCP Q28HS9_XENTR Q28HS9_XENTR AGFIFTTSLPPMLLSGAIASVRVLKSEEG--QALRRQHQRNVKLMRQMLMDSGLPVVHCP Q66JC7_XENTR Q66JC7_XENTR AGFIFTTSLPPMLLSGAIASVRVLKSEEG--QALRRQHQRNVKLMRQMLMDSGLPVVHCP Q6EE56_XENLA Q6EE56_XENLA AGFIFTTSLPPMLLSGAIASVKVLKSEEG--QALRRQHQRNVKLMRQMLMDSGLPVVHCP Q6PAZ6_XENLA Q6PAZ6_XENLA AGFIFTTSLPPMLLSGAIASVKVLKSEEG--QALRRQHQRNVKLMRQMLMDSGLPVVHCP HEM1_CHICK HEM1_CHICK AGFIFTTSLPPMLLAGALESVRTLKSAEG--QVLRRQHQRNVKLMRQMLMDAGLPVVHCP HEM1_DELLE HEM1_DELLE AGFIFTTSLPPMLLAGALESVRILKSTEG--RVLRRQHQRNVKLMRQMLMDASLPVVHCP HEM1_MOUSE HEM1_MOUSE AGFIFTTSLPPMLLAGALESVRILKSSEG--RALRRQHQRNVKLLRQMLMDAGLPVIHCP Q3V0B2_MOUSE Q3V0B2_MOUSE AGFIFTTSLPPMLLAGALESVRILKSSEG--RALRRQHQRNVKLLRQMLMDAGLPVIHCP HEM1_RAT HEM1_RAT AGFIFTTSLPPMLLAGALESVRILKSNEG--RALRRQHQRNVKLMRQMLMDAGLPVIHCP Q4R6D0_MACFA Q4R6D0_MACFA AGFIFTTSLPPMLLAGALESVRILKSAEG--RALRRQHQRNVKLMRQMLMDAGLPVVHCP HEM1_PONAB HEM1_PONAB AGFIFTTSLPPMLLAGALESVRILKSAEG--RVLRRQHQRNVKLMRQMLMDAGLPVVHCP B4DVA0_HUMAN B4DVA0_HUMAN AGFIFTTSLPPMLLAGALESVRILKSAEG--RVLRRQHQRNVKLMRQMLMDAGLPVVHCP HEM1_HUMAN HEM1_HUMAN AGFIFTTSLPPMLLAGALESVRILKSAEG--RVLRRQHQRNVKLMRQMLMDAGLPVVHCP Q5JAM2_HUMAN Q5JAM2_HUMAN AGFIFTTSLPPMLLAGALESVRILKSAEG--RVLRRQHQRNVKLMRQMLMDAGLPVVHCP B4DDG9_HUMAN B4DDG9_HUMAN AGFIFTTSLPPMLLAGALESVRILKSAEG--RVLRRQHQRNVKLMRQMLMDAGLPVVHCP HEM1_BOVIN HEM1_BOVIN AGFIFTTSLPPMLLAGALESVRILRSTEG--RTLRRQHQRNVKLMRQMLMDAGLPVVHCP Q401C4_CAPHI Q401C4_CAPHI AGFIFTTSLPPMLLAGALESVRILRSAEG--QALRRQHQRNVKLMRQMLMDAGLPVVHCP Q7T2F0_DANRE Q7T2F0_DANRE AGFIFTTSLPPMLLSGARQSVQILKSEEG--RTLRRKHQRNVTLLRQMLMDSGLPVIHCP B5X2H2_SALSA B5X2H2_SALSA AGFIFTTSLPPMLLAGARESIQTLKGEEG--RSLRRKHQRNVKLLRQMLMDSGLPVVHCP HEM1_OPSTA HEM1_OPSTA AGFIFTTSLPPMLLAGAKQSIQILKGEEG--CTLRRKHQRNVKLLRQMLMDSGLPVVHCP Q4RX09_TETNG Q4RX09_TETNG AGFIFTTSLPPMLLAGARQSIQVLKSEEG--RSLRRNHQRNVKLLRQMLMDSGLPVVHCP HEM0_BOVIN HEM0_BOVIN AGFIFTTSLPPMVLSGALESVRLLKGEEG--QALRRAHQRNVKHMRQLLMDRGLPVIPCP HEM0_DELLE HEM0_DELLE AGFIFTTSLPPMVLSGALESVRLLKGEEG--QALRRAHQRNVKHMRQLLMDRGLPVIPCP HEM0_RAT HEM0_RAT AGFIFTTSLPPMVLSGALESVRLLKGEEG--QALRRAHQRNVKHMRQLLMDRGFPVIPCP Q642C1_RAT Q642C1_RAT AGFIFTTSLPPMVLSGALESVRLLKGEEG--QALRRAHQRNVKHMRQLLMDRGFPVIPCP Q8R1G3_MOUSE Q8R1G3_MOUSE AGFIFTTSLPPMVLSGALESVRLLKGEEG--QALRRAHQRNVKHMRQLLMDRGFPVIPCP Q3TNI1_MOUSE Q3TNI1_MOUSE AGFIFTTSLPPMVLSGALESVRLLKGEEG--QALRRAHQRNVKHMRQLLMDRGFPVIPCP Q3TA47_MOUSE Q3TA47_MOUSE AGFIFTTSLPPMVLSGALESVRLLKGEEG--QALRRAHQRNVKHMRQLLMDRGFPVIPCP A2AFM1_MOUSE A2AFM1_MOUSE AGFIFTTSLPPMVLSGALESVRLLKGEEG--QALRRAHQRNVKHMRQLLMDRGFPVIPCP A2AFM0_MOUSE A2AFM0_MOUSE AGFIFTTSLPPMVLSGALESVRLLKGEEG--QALRRAHQRNVKHMRQLLMDRGFPVIPCP HEM0_MOUSE HEM0_MOUSE AGFIFTTSLPPMVLSGALESVRLLKGEEG--QALRRAHQRNVKHMRQLLMDRGFPVIPCP Q9DDC3_PLAFE Q9DDC3_PLAFE AGFIFTTSLPPMLLAGARESIQVLKGEEG--RSLRRKHQRNVKLLRQMLMDSG------- B7ZB88_HUMAN B7ZB88_HUMAN NDYLGMSR-HPQVLQATQETLQRHGAGAGGTRNISGTSKFHVELEQEL------------ HEM0_PONAB HEM0_PONAB AGFIFTTSLPPMVLSGALESVRLLKGEEG--QALRRAHQRNVKHMRQLLMDRGLPVIPCP A8K3F0_HUMAN A8K3F0_HUMAN AGFIFTTSLPPMVLSGALESVRLLKGEEG--QALRRAHQRNVKHMRQLLMDRGLPVIPCP HEM0_HUMAN HEM0_HUMAN AGFIFTTSLPPMVLSGALESVRLLKGEEG--QALRRAHQRNVKHMRQLLMDRGLPVIPCP A8K6C4_HUMAN A8K6C4_HUMAN AGFIFTTSLPPMVLSGALESVRLLKGEEG--QALRRAHQRNVKHMRQLLMDRGLPVIPCP Q8N6H3_HUMAN Q8N6H3_HUMAN AGFIFTTSLPPMVLSGALESVRLLKGEEG--QALRRAHQRNVKHMRQLLMDRGLPVIPCP Q5JZF5_HUMAN Q5JZF5_HUMAN AGFIFTTSLPPMVLSGALESVRLLKGEEG--QALRRAHQRNVKHMRQLLMDRGLPVIPCP HEM0_DANRE HEM0_DANRE AGFIFTTSLPPMVLAGALESVRVLKSDEG--QALRRAHQRNVKHMRQLLLDAGLPVVNCP Q4SYE6_TETNG Q4SYE6_TETNG AGFIFTTALPPMVLSGALESVRVLKSPEG--QALRRAHQRNVKHMRQLLMDKGLPVLNCP HEM0_OPSTA HEM0_OPSTA AGFIFTTSLPPMILAGALESVRVLKSPEG--QLLRRAHQRNVKYMRQLLMDKGLPVVNCP Q6I749_ORYLA Q6I749_ORYLA AGFIFTTALPPMVLAGALESVRILKSAEG--QVLRRAHQRNVKHMRQLLMDKGLPVVNCP Q6EEC2_LATCH Q6EEC2_LATCH ADFIFTTSLPPMVLGGALESVRILKSEEG--QVLRRAHQRNVKNMRQLLMDVGLPVINCP Q6EEC1_PRODO Q6EEC1_PRODO AGFIFTTSLPPMVLAGALESVRVLKGEEG--QALRRAHQRNVKHMRQLLMDAGLPVMNCA Q5XG49_XENLA Q5XG49_XENLA AGFIFTTSLPPMVLAGAVESVRVLKSEEG--QALRRAHQRNVKHMRQLLMDAGLPVINCP Q68F30_XENLA Q68F30_XENLA AGFIFTTSLPPMVLAGAVESVRVLKSEEG--QALRRAHQRNVKHMRQLLMDAGLPVINCP Q6DF22_XENTR Q6DF22_XENTR AGFIFTTSLPPMVLAGAVESVRVLKSEEG--QALRRAHQRNVKHMRQLLMDAGLPVINCP MATCH .:: : * .: .: . * : : . : : CONSENSUS AGFIFTTSLPPM?L?GA?ESV??LK??EG????LRR?HQRNVK?MRQ?LMD?GLPV??CP

HEM0_CHICK HEM0_CHICK SHIVPVRW-DAEANTRLSRALLEEHGLYVQAINHPTVPRGQELLLRIAPTPHHSPPMLEN Q86LZ7_BRALA Q86LZ7_BRALA SHIIPIRVGNAEKNTDVCNDMMTKHKIYVQAI---------------------------- Q9XYA5_MYXGL Q9XYA5_MYXGL SHIIPVLVGNAAHNTELCNELMSRHNIYVQAINYPTVPRGEEM-LRVVVTPHHTPQMMQY Q4S5J1_TETNG Q4S5J1_TETNG SHIIPVRVADAEKNTQICDIMMSRYNIYVQAINYPTVAKGEEL-LRIAPTPHHTPQMMLT Q6EEC3_PRODO Q6EEC3_PRODO SHIIPIRVSDAAKNNQICDTLMSRYNIYVQAI---------------------------- Q6EEC4_LATCH Q6EEC4_LATCH SHIIPIRVSDAAKNTQVCDELMSKYNIYV------------------------------- Q6DKE7_XENLA Q6DKE7_XENLA SHIIPIRVSEAAKNTEICDKLLRDYNIYVQAINYPTVPRGEEL-LRIAPTPHHNPQMMTY Q28HS9_XENTR Q28HS9_XENTR SHIIPIRVSDAAKNTEICDKLMRDYNIYVQAINYPTVARGEEL-LRIAPTPHHNPQMMSY Q66JC7_XENTR Q66JC7_XENTR SHIIPIRVSDAAKNTEICDKLMRDYNIYVQAINYPTVARGEEL-LRIAPTPHHNPQMMSY Q6EE56_XENLA Q6EE56_XENLA SHIIPIRVSDAAKNTXICDKLMRDYSIYVQAINYPTVPRGEEL-LRIAPTPHHNPQ---- Q6PAZ6_XENLA Q6PAZ6_XENLA SHIIPIRVSNAAKNTEICDKLMRDYNIYVQAINYPTVPRGEEL-LRIAPTPHHNPQMMSY HEM1_CHICK HEM1_CHICK SHIIPIRVADAAKNTEICDKLMSQHSIYVQAINYPTVPRGEEL-LRIAPTPHHTPQMMSY HEM1_DELLE HEM1_DELLE SHIIPVRVADAAKNTEVCNELMSRHNIYVQAINYPTVRRGEEL-LRIAPTPHHTPQMMNY HEM1_MOUSE HEM1_MOUSE SHIIPVRVADAAKNTEICDELMTRHNIYVQAINYPTVPRGEEL-LRIAPTPHHTPQMMNF Q3V0B2_MOUSE Q3V0B2_MOUSE SHIIPVRVADAAKNTEICDELMTRHNIYVQAINYPTVPRGEEL-LRIAPTPHHTPQMMNF HEM1_RAT HEM1_RAT SHIIPVRVADAAKNTEICDELMTRHNIYVQAINYPTVPRGEEL-LRIAPTPHHTPQMMNF Q4R6D0_MACFA Q4R6D0_MACFA SHIIPVRVADAAKNTEVCDELMSRHNIYVQAINYPTVPRGEEL-LRIAPTPHHTPQMMNY HEM1_PONAB HEM1_PONAB SHIIPVRVADAAKNTEVCDELMSRHNIYVQAINYPTVPRGEEL-LRIAPTPHHTPQMMNY B4DVA0_HUMAN B4DVA0_HUMAN SHIIPVRVADAAKNTEVCDELMSRHNIYVQAINYPTVPRGEEL-LRIAPTPHHTPQMMNY HEM1_HUMAN HEM1_HUMAN SHIIPVRVADAAKNTEVCDELMSRHNIYVQAINYPTVPRGEEL-LRIAPTPHHTPQMMNY Q5JAM2_HUMAN Q5JAM2_HUMAN SHIIPVRVADAAKNTEVCDELMSRHNIYVQAINYPTVPRGEEL-LRIAPTPHHTPQMMNY B4DDG9_HUMAN B4DDG9_HUMAN SHIIPVRVADAAKNTEVCDELMSRHNIYVQAINYPTVPRGEEL-LRIAPTPHHTPQMMNY HEM1_BOVIN HEM1_BOVIN SHIIPVRVADAAKNTEVCDELMTRHNIYVQAINYPTVPRGEEL-LRIAPTPHHTPQMMSY Q401C4_CAPHI Q401C4_CAPHI SHIIPVRVADAAKNTEVCDELMTRHNIYVQAINYPTVPRGEEL-LRIAPTPHHTPQMMSY Q7T2F0_DANRE Q7T2F0_DANRE SHIIPVRVADAEKNTEVCDIMMSRYNIYVQAINYPTVARGEEL-LRIAPTPHHTPQMMKY B5X2H2_SALSA B5X2H2_SALSA SHIIPVRVSDAEKNTEVCDVMMTRYNIYVQAINYPTVARGEEL-LRIAPTPHHTPQMMTH HEM1_OPSTA HEM1_OPSTA SHIIPIRVSDAEKNTKVCDLMMSHHNIYVQAINYPTVARGDEL-LRIAPTPHHTPEMMKY Q4RX09_TETNG Q4RX09_TETNG SHIIPVRVSDAEKNTKVCDIMMSRHNIYVQAINYPTVARGEEL-LRIAATPHHTPEMMKY HEM0_BOVIN HEM0_BOVIN SHIIPIRVGDAMLNTRICDLLLSKYGIYVQAINYPTVPRGEEL-LRLAPSPHHSPQMMED HEM0_DELLE HEM0_DELLE SHIIPIRVGDAALNSRICDLLLSKHGIYVQAINYPTVPRGEEL-LRLAPSPHHSPQMMED HEM0_RAT HEM0_RAT SHIIPIRVGNAALNSKICDLLLAKHSIYVQAINYPTVPRGEEL-LRLAPSPHHSPQMMEN Q642C1_RAT Q642C1_RAT SHIIPIRVGNAALNSKICDLLLAKHSIYVQAINYPTVPRGEEL-LRLAPSPHHSPQMMEN Q8R1G3_MOUSE Q8R1G3_MOUSE SHIIPIRVGNAALNSKICDLLLSKHSIYVQAINYPTVPRGEEL-LRLAPSPHHSPQMMEN Q3TNI1_MOUSE Q3TNI1_MOUSE SHIIPIRVGNAALNSKICDLLLSKHSIYVQAINYPTVPRGEEL-LRLAPSPHHSPQMMEN Q3TA47_MOUSE Q3TA47_MOUSE SHIIPIRVGNAALNSKICDLLLSKHSIYVQAINYPTVPRGEEL-LRLAPSPHHSPQMMEN A2AFM1_MOUSE A2AFM1_MOUSE SHIIPIRVGNAALNSKICDLLLSKHSIYVQAINYPTVPRGEEL-LRLAPSPHHSPQMMEN A2AFM0_MOUSE A2AFM0_MOUSE SHIIPIRVGNAALNSKICDLLLSKHSIYVQAINYPTVPRGEEL-LRLAPSPHHSPQMMEN HEM0_MOUSE HEM0_MOUSE SHIIPIRVGNAALNSKICDLLLSKHSIYVQAINYPTVPRGEEL-LRLAPSPHHSPQMMEN Q9DDC3_PLAFE Q9DDC3_PLAFE -----------------C------------------------------------------ B7ZB88_HUMAN B7ZB88_HUMAN ----------AELHQKDSALLFS------------------------------------- HEM0_PONAB HEM0_PONAB SHIIPIRVGNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEEL-LRLAPSPHHSPQMMED A8K3F0_HUMAN A8K3F0_HUMAN SHIIPIRVGNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEEL-LRLAPSPHHSPQMMED HEM0_HUMAN HEM0_HUMAN SHIIPIRVGNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEEL-LRLAPSPHHSPQMMED A8K6C4_HUMAN A8K6C4_HUMAN SHIIPIRVGNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEEL-LRLAPSPHHSPQMMED Q8N6H3_HUMAN Q8N6H3_HUMAN SHIIPIRVGNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEEL-LRLAPSPHHSPQMMED Q5JZF5_HUMAN Q5JZF5_HUMAN SHIIPIRVGNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEEL-LRLAPSPHHSPQMMED HEM0_DANRE HEM0_DANRE SHIIPIRVGNAAKNSEVCDILLEKHNIYVQAINYPTVPRGEEL-LRLAPSPFHNPIMMNY Q4SYE6_TETNG Q4SYE6_TETNG SHIIPIRVGNAELNTKVCDSLLERHNIYVQAINYPTVPRGEEL-LRLAPTPHHNPAMMEY HEM0_OPSTA HEM0_OPSTA SHIIPIRVGNAELNTKVCDSLLEKHNIYVQAINYPTVPRGQEL-LRLAPSPHHHPAMMEY Q6I749_ORYLA Q6I749_ORYLA SHIIPIRVGNAELNTKVCDILLEKY----------------------------------- Q6EEC2_LATCH Q6EEC2_LATCH SHIIPIQVSDAAKNTQISNLLLESHDIYVQAI---------------------------- Q6EEC1_PRODO Q6EEC1_PRODO SHTIPIRVSNAEKNTQICDTLLTKHNIYVQAI---------------------------- Q5XG49_XENLA Q5XG49_XENLA SHIIPIRVGNAAINTRICDILLSQHNIYVQAINYPTVPRGEEL-LRLAPSPHHTPDMMSY Q68F30_XENLA Q68F30_XENLA SHIIPIRVGNAAINSRICDVLLSQYNIYVQAINYPTVPRGEEL-LRLAPSPHHTPDMMTY Q6DF22_XENTR Q6DF22_XENTR SHIIPIRVGNAAINTRICDVLLSQYNIYVQAINYPTVPRGEEL-LRLAPSPHHTPDMMNY MATCH . CONSENSUS SHIIP?RV??A??N???CD?L?????IYVQAINYPTV?RGEEL?LR?AP?PHH?P?MM??

HEM0_CHICK HEM0_CHICK LADKLSECWGAVGLPREDPPGPSCSSCHRPLHLSLLSPLERDQFGVRGAAAG----- Q86LZ7_BRALA Q86LZ7_BRALA --------------------------------------------------------- Q9XYA5_MYXGL Q9XYA5_MYXGL FVEHLTNSWKDIGLNLRPHASAECNYCKMPIHFELMSEHDQVYFDGMSRKLGIAAA- Q4S5J1_TETNG Q4S5J1_TETNG FVDRLVQTWKEVGLQPRAHSSAECHFCQQPLHFDLMSEREKSFFTGLNHL-IPAVA- Q6EEC3_PRODO Q6EEC3_PRODO --------------------------------------------------------- Q6EEC4_LATCH Q6EEC4_LATCH --------------------------------------------------------- Q6DKE7_XENLA Q6DKE7_XENLA FLDKLLITWKSVDLELKPHSTAECNFCRQPLHFEVMSEREKSYFTGLSKL-ISARA- Q28HS9_XENTR Q28HS9_XENTR FLDKLLTTWKSVDLELKPHPTAECNFCRQPLHFEVMSEREKSYFSGLSKM-ISVRA- Q66JC7_XENTR Q66JC7_XENTR FLDKLLTTWKSVDLELKPHPTAECNFCRQPLHFEVMSEREKSYFSGLSKM-ISVRA- Q6EE56_XENLA Q6EE56_XENLA --------------------------------------------------------- Q6PAZ6_XENLA Q6PAZ6_XENLA FLDKLLITWKSANLELKPHSTAECNFCRQPLHFEVMSEREKSYFTGLSKL-ISARA- HEM1_CHICK HEM1_CHICK FLEKLLATWKDVGLELKPHSSAECNFCRRPLHFEVMSERERSYFSGMSKL-LSVSA- HEM1_DELLE HEM1_DELLE FVENLLATWKRVGLELKPHSSAECNFCRRPLHFEVMSEREKSYFFGMSKL-VSAQD- HEM1_MOUSE HEM1_MOUSE FVEKLLVTWKRVGLELKPHSSAECNFCRRPLHFEVMSEREKAYFSGMSKM-VSAQA- Q3V0B2_MOUSE Q3V0B2_MOUSE FVEKLLVTWKRVGLELKPHSSAECNFCRRPLHFEVMSEREKAYFSGMSKM-VSAQA- HEM1_RAT HEM1_RAT FLEKLLLTWKRVGLELKPHSSAECNFCRRPLHFEVMSEREKAYFSGMSKM-VSAQA- Q4R6D0_MACFA Q4R6D0_MACFA FLENLLVTWKQVGLELKPHSSAECNFCRRPLHFEVMSEREKSYFSGLSKL-VSAQA- HEM1_PONAB HEM1_PONAB FLENLLVTWKQVGLELEPHSSAECNFCRRPLHFEVMSEREKSYFSGLSKL-VSAQA- B4DVA0_HUMAN B4DVA0_HUMAN FLENLLVTWKQVGLELKPHSSAECNFCRRPLHFEVMSEREKSYFSGLSKL-VSAQA- HEM1_HUMAN HEM1_HUMAN FLENLLVTWKQVGLELKPHSSAECNFCRRPLHFEVMSEREKSYFSGLSKL-VSAQA- Q5JAM2_HUMAN Q5JAM2_HUMAN FLENLLVTWKQVGLELKPHSSAECNFCRRPLHFEVMSEREKSYFSGLSKL-VSAQA- B4DDG9_HUMAN B4DDG9_HUMAN FLENLLVTWKQVGLELKPHSSAECNFCRRPLHFEVMSEREKSYFSGLSKL-VSAQA- HEM1_BOVIN HEM1_BOVIN FVDNLLATWKRVGLELKPHSSAECNFCRRPLHFEMMSEREKSYFSGMSKL-VSAQA- Q401C4_CAPHI Q401C4_CAPHI FVDHLLATWKQVGLEL----------------------------------------- Q7T2F0_DANRE Q7T2F0_DANRE FVDKLTQTWTEVGLPLKPHSSAECNFCRQPLHFEIMSEREKSYFSGLSQP-ISACG- B5X2H2_SALSA B5X2H2_SALSA FVEKLVQTWKESGLPLKPHSSGECNFCQQPLHFELMTEREQSYFRGLSHP-ISAHA- HEM1_OPSTA HEM1_OPSTA FVDRLVQTWKEVGLELKPHSSAECTFCQQPLHFEVMNEREKSYFSGLSHL-VSVCA- Q4RX09_TETNG Q4RX09_TETNG FVEKLVHTWKEAGLELKPHSSAECNFCQQPLHFELMSEREKSYFSGLSHP-ISACA- HEM0_BOVIN HEM0_BOVIN FVEKLLEAWTEVGLPLQDISIAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA- HEM0_DELLE HEM0_DELLE FVEKLLAAWTEVGLPLQDVSIAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA- HEM0_RAT HEM0_RAT FVEKLLLAWTEVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA- Q642C1_RAT Q642C1_RAT FVEKLLLAWTEVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA- Q8R1G3_MOUSE Q8R1G3_MOUSE FVEKLLLAWTEVGLPLQDVSVAACNFCHRPVHFELMSEWERSYFGNMGPQYVTTYA- Q3TNI1_MOUSE Q3TNI1_MOUSE FVEKLLLAWTEVGLPLQDVSVAACNFCHRPVHFELMSEWERSYFGNMGPQYVTTYA- Q3TA47_MOUSE Q3TA47_MOUSE FVEKLLLAWTEVGLPLQDVSVAACNFCHRPVHFELMSEWERSYFGNMGPQYVTTYA- A2AFM1_MOUSE A2AFM1_MOUSE FVEKLLLAWTEVGLPLQDVSVAACNFCHRPVHFELMSEWERSYFGNMGPQYVTTYA- A2AFM0_MOUSE A2AFM0_MOUSE FVEKLLLAWTEVGLPLQDVSVAACNFCHRPVHFELMSEWERSYFGNMGPQYVTTYA- HEM0_MOUSE HEM0_MOUSE FVEKLLLAWTEVGLPLQDVSVAACNFCHRPVHFELMSEWERSYFGNMGPQYVTTYA- Q9DDC3_PLAFE Q9DDC3_PLAFE -------------------------LCALP--------------------------- B7ZB88_HUMAN B7ZB88_HUMAN ----------------------SCFVANDSTLFTLA--------------------- HEM0_PONAB HEM0_PONAB FVEKLLLAWTEVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA- A8K3F0_HUMAN A8K3F0_HUMAN FVEKLLLAWTAVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA- HEM0_HUMAN HEM0_HUMAN FVEKLLLAWTAVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA- A8K6C4_HUMAN A8K6C4_HUMAN FVEKLLLAWTAVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA- Q8N6H3_HUMAN Q8N6H3_HUMAN FVEKLLLAWTAVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA- Q5JZF5_HUMAN Q5JZF5_HUMAN FVEKLLLAWTAVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA- HEM0_DANRE HEM0_DANRE FAEKLLDVWQEVGLPLNGPAQASCTFCDRPLHFDLMSEWEKSYFGNMEPRYITVAAQ Q4SYE6_TETNG Q4SYE6_TETNG FVEKLVEVWQEAGLPLKSPTVASCTFCDRPLHFALMSEWERSYFGNMEPQYIT---- HEM0_OPSTA HEM0_OPSTA FVDKLVEVWQEAGLLLNGPATVSCTFCDRPLHFDLMSEWEKSYFGNMEPQYITMSA- Q6I749_ORYLA Q6I749_ORYLA --------------------------------------------------------- Q6EEC2_LATCH Q6EEC2_LATCH --------------------------------------------------------- Q6EEC1_PRODO Q6EEC1_PRODO --------------------------------------------------------- Q5XG49_XENLA Q5XG49_XENLA FVESLVRVWKEAGIPLHTPSAAECNFCHRPLHFDLMSEWERTYFGNMEPKYITMYA- Q68F30_XENLA Q68F30_XENLA FVESVVSAWKEVGMPLHTPSAAECNFCHRPLHFDLMSEWERTYFGNMEPKYITMYA- Q6DF22_XENTR Q6DF22_XENTR FVESLVSAWKEVGMPLHTPSAAECNFCHRPLHFDLMSEWERTYFGNMEPKYITMYA- MATCH CONSENSUS F???L???W??????L???????C??C??P?HF??M?E?E???F?????????????


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