Alignment of the gene Family HBG006297 of HOVERGEN

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Isoforms are ON
O73632_COTJA O73632_COTJA ----------------------MALLLALLLRSL-------------------------- A2AFL4_MOUSE A2AFL4_MOUSE NIRKPLCSNSVVGACTLISLTTAVILGHLMLRELMLLPQDLHESSSGLWKTYRPHHQEGY LYAG_MOUSE LYAG_MOUSE NIRKPLCSNSVVGACTLISLTTAVILGHLMLRELMLLPQDLHESSSGLWKTYRPHHQEGY LYAG_RAT LYAG_RAT NIRKPLCSNSVVGACTLVSLTTAVILGHLMLRELMLLPQDLHESSSGLWKTYRPHHQESY LYAG_BOVIN LYAG_BOVIN MMRWPPCSRPLLGVCTLLSL---ALLGHILLHDLEVVPRELRGFSQ--DEIHQACQPGAS A6NFM4_HUMAN A6NFM4_HUMAN GVRHPPCSHRLLAVCALVSLATAALLGHILLHDFLLVPRELSGSSPVLEETHPAHQQGAS LYAG_HUMAN LYAG_HUMAN GVRHPPCSHRLLAVCALVSLATAALLGHILLHDFLLVPRELSGSSPVLEETHPAHQQGAS LYAG_PONAB LYAG_PONAB RVRHPPCSRRLLAICALVSLATAALLGHILLHDFLLVPRELSGSSPVLEETHPAHQQGAS O73626_COTJA O73626_COTJA ---MRSYQKLRTAVPQLVLSQEEEEEEEDATTPTPAGRSKLAPWWVGSGLLITAVLLSTI Q4SML8_TETNG Q4SML8_TETNG ------------------------------------------------------------ Q6XK24_MOUSE Q6XK24_MOUSE ------MAGRRFKKFSKLELVLIVLLLVLFIIAVVLI--------VLLANSTPENAIGAE MGAL1_HUMAN MGAL1_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

O73632_COTJA O73632_COTJA ----------PSASSSAD--SACSLPPDE-RFDCGPERL--LARADCEARGCCYAPS--- A2AFL4_MOUSE A2AFL4_MOUSE KPGPLHIQEQTEQPKEAP--TQCDVPPSS-RFDCAPDKG--ISQEQCEARGCCYVPA--- LYAG_MOUSE LYAG_MOUSE KPGPLHIQEQTEQPKEAP--TQCDVPPSS-RFDCAPDKG--ISQEQCEARGCCYVPA--- LYAG_RAT LYAG_RAT EPAPLHIQEHAEQLRAVP--TQCDVTPNS-RFDCAPDKG--ITQEQCEARGCCWVPA--- LYAG_BOVIN LYAG_BOVIN SP------ECRGSPRAAP--TQCDLPPNS-RFDCAPDKG--ITPQQCEARGCCYMPA--- A6NFM4_HUMAN A6NFM4_HUMAN RPGPRDAQAHPGRPRAVP--TQCDVPPNS-RFDCAPDKA--ITQEQCEARGCCYIPA--- LYAG_HUMAN LYAG_HUMAN RPGPRDAQAHPGRPRAVP--TQCDVPPNS-RFDCAPDKA--ITQEQCEARGCCYIPA--- LYAG_PONAB LYAG_PONAB RPGPRDAQAHLGRPRAVP--TQCDVPPNS-RFDCAPDKA--ITREQCDARGCCYIPA--- O73626_COTJA O73626_COTJA TVWVLRQVSRGWHGPAPP--AQCHLVPESHRYDCYPERNVVVTQELCESRGCCFI-Q--- Q4SML8_TETNG Q4SML8_TETNG -------------PAAPPLGDTCGSIPESWRFDCYPERGVIVTRELCEARNCCFIPASSS Q6XK24_MOUSE Q6XK24_MOUSE TTGTPDTTVTRTTLNSPN----CPVLSELERINCIPDQS--SNKGTCDERGCCWDPQ--- MGAL1_HUMAN MGAL1_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ??????????????????????C???P???R?DC?P??????????C??RGCC??P????

O73632_COTJA O73632_COTJA ------GSGGSGGPPWCFFPLGYRSYRAD-NVTATAGGYSARLRR-VVPSFLPADVGTLR A2AFL4_MOUSE A2AFL4_MOUSE ---GQVLKEPQIGQPWCFFPPSYPSYRLE-NLSSTESGYTATLTR-TSPTFFPKDVLTLQ LYAG_MOUSE LYAG_MOUSE ---GQVLKEPQIGQPWCFFPPSYPSYRLE-NLSSTESGYTATLTR-TSPTFFPKDVLTLQ LYAG_RAT LYAG_RAT ---GQVLNGPVMGQPWCFFPPSYPSYRLE-NLSSTESGYTATLTR-TSPTFFPKDVLTLQ LYAG_BOVIN LYAG_BOVIN ----EWPPDAQMGQPWCFFPPSYPSYRLE-NLTTTETGYTATLTR-AVPTFFPKDIMTLR A6NFM4_HUMAN A6NFM4_HUMAN ---KQGLQGAQMGQPWCFFPPSYPSYKLE-NLSSSEMGYTATLTR-TTPTFFPKDILTLR LYAG_HUMAN LYAG_HUMAN ---KQGLQGAQMGQPWCFFPPSYPSYKLE-NLSSSEMGYTATLTR-TTPTFFPKDILTLR LYAG_PONAB LYAG_PONAB ---KQGLRGAQMGQPWCFFPPSYPSYKLE-NLSSSEMGYTATLTR-TTPTFFPKDILTLR O73626_COTJA O73626_COTJA ---TLPAVGGKRGVPWCFYPPDFPSYVVQ-SLNQTVLGMTGLLVR-REKAYYPKDIQMLR Q4SML8_TETNG Q4SML8_TETNG SSSSRPPPSGGNGVPWCFYPADFPSYRLV-SINDTSLGQKGTLVK-EVRTYYPADILTLE Q6XK24_MOUSE Q6XK24_MOUSE ---------GSISVP-CYYSRNH-GYKMESDVVNTNAGFTATLKNLPSAPVFGNSIENIL MGAL1_HUMAN MGAL1_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ????????????G?PWCF?P????SY???????????G????L?????????P?D???L?

O73632_COTJA O73632_COTJA LDVAMETESRLRFTPRDPARQRYEVPMATPRVST-RAADTL-YGVQLLQDPFGIVVFRQP A2AFL4_MOUSE A2AFL4_MOUSE LEVLMETDSRLHFKIKDPASKRYEVPLETPRVLS-QAPSPL-YSVEFSEEPFGVIVRRKL LYAG_MOUSE LYAG_MOUSE LEVLMETDSRLHFKIKDPASKRYEVPLETPRVLS-QAPSPL-YSVEFSEEPFGVIVRRKL LYAG_RAT LYAG_RAT LEVLMETDSRLHFMIKDPTSKRYEVPLETPRVLS-QAPSPL-YSVEFSEEPFGVIVRRKL LYAG_BOVIN LYAG_BOVIN LDMLMETESRLHFTIKDPANRRYEVPLETPRVYS-QAPFTL-YSVEFSEEPFGVVVRRKL A6NFM4_HUMAN A6NFM4_HUMAN LDVMMETENRLHFTIKDPANRRYEVPLETPHVHS-RAPSPL-YSVEFSEEPFGVIVRRQL LYAG_HUMAN LYAG_HUMAN LDVMMETENRLHFTIKDPANRRYEVPLETPHVHS-RAPSPL-YSVEFSEEPFGVIVHRQL LYAG_PONAB LYAG_PONAB LDVMMETENRLHFTIKDPANRRYEVPLETPRVHS-RAPSPL-YSVEFSEEPFGVIVRRQL O73626_COTJA O73626_COTJA MDVEFQTNTRLHIKITDAANPRYEVPLEVPRVTK-RAENPI-YSLEISQDPFGVLLRRQG Q4SML8_TETNG Q4SML8_TETNG VDLRHETDTRLHVKITDPSNPRFEVPISVPAATK-KAESPD-YLVEVSRQPFGLVVRRRS Q6XK24_MOUSE Q6XK24_MOUSE LTAEYQTSNRFHFKLTDQTKKRYEVPHEHVQPFSGNAPSSLNYKVEVSKEPFSIKVTRKS MGAL1_HUMAN MGAL1_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ??????T??RLH????D????RYEVP???P??????A?????Y?VE?S??PFG??V?R??

O73632_COTJA O73632_COTJA DGQVLLNTSVAPLFFADQFLQISTSLPSRFISGLGERL-APLILDTAWTKVTLWNRDMAP A2AFL4_MOUSE A2AFL4_MOUSE GGRVLLNTTVAPLFFADQFLQLSTSLPSQHITGLGEHL-SPLMLSTDWARITLWNRDTPP LYAG_MOUSE LYAG_MOUSE GGRVLLNTTVAPLFFADQFLQLSTSLPSQHITGLGEHL-SPLMLSTDWARITLWNRDTPP LYAG_RAT LYAG_RAT GGRVLLNTTVAPLFFADQFLQLSTSLPSQHIAGLGEHL-SPLMLSTEWTRITLWNRDVAP LYAG_BOVIN LYAG_BOVIN DGRVLLNTTVAPLFFADQFLQLSTSLPSQHITGLAEHL-GSLMLSTNWTKITLWNRDIAP A6NFM4_HUMAN A6NFM4_HUMAN DGRVLLNTTVAPLFFADQFLQLSTSLPSQYITGLAEHL-SPLMLSTSWTRITLWNRDLAP LYAG_HUMAN LYAG_HUMAN DGRVLLNTTVAPLFFADQFLQLSTSLPSQYITGLAEHL-SPLMLSTSWTRITLWNRDLAP LYAG_PONAB LYAG_PONAB DGRVLLNTTVAPLFFADQFLQLSTSLPSQYITGLAEHL-SPLMLSTSWTRVTLWNRDLAP O73626_COTJA O73626_COTJA TGTVLLNTTVAPLIFADQFLQISTTLPSRFLYGLGEHR-STLLHSLDWNTLTLWARDVAP Q4SML8_TETNG Q4SML8_TETNG SGVVLLNTTVAPLFYADQFLQMSTSLPSPFVYGLAEHR-SSFLQEVRWNTLSLWARDVPP Q6XK24_MOUSE Q6XK24_MOUSE NNRVLFDSSIGPLLFSDQFLQFSTHLPSANVYGLGEHVHQQYRHNMNWKTWPMFSRDTTP MGAL1_HUMAN MGAL1_HUMAN -----------------MFLSISTRLPSQYIYGFGETEHTTFRRNMNWNTWGMFAHDEPP MATCH **.:** *** : *:.* . * :: :* .* CONSENSUS ?G?VLLNT?VAPL?FADQFLQ?ST?LPS????GL?EH??????????W????LW?RD??P

O73632_COTJA O73632_COTJA AP-QVNLYGSHPFYLVLEDG-GSAHGVFLLNSNAMDVLLQPCPALTWRTTGGILDFYIFL A2AFL4_MOUSE A2AFL4_MOUSE SQ-GTNLYGSHPFYLALEDG-GLAHGVFLLNSNAMDVILQPSPALTWRSTGGILDVYVFL LYAG_MOUSE LYAG_MOUSE SQ-GTNLYGSHPFYLALEDG-GLAHGVFLLNSNAMDVILQPSPALTWRSTGGILDVYVFL LYAG_RAT LYAG_RAT SQ-GVNLYGSHPFYLALEDG-GLAHGVFLLNSNAMDVVLQPSPALTWRSTGGILDVYVFL LYAG_BOVIN LYAG_BOVIN EP-NVNLYGSHPFYLVLEDG-GLAHGVFLLNSNAMDVVLQPSPALSWRSTGGILDVYIFL A6NFM4_HUMAN A6NFM4_HUMAN TP-GANLYGSHPFYLALEDG-GSAHGVFLLNSNAMDVVLQPSPALSWRSTGGILDVYIFL LYAG_HUMAN LYAG_HUMAN TP-GANLYGSHPFYLALEDG-GSAHGVFLLNSNAMDVVLQPSPALSWRSTGGILDVYIFL LYAG_PONAB LYAG_PONAB TP-GANLYGSHPFYLALEDG-GSAHGVFLLNSNAMDVVLQPSPALSWRSTGGILDVYIFL O73626_COTJA O73626_COTJA TE-SFNLYGAHPFYLLMEEG-GDAHGVFLLNSNAMEVALQPAPGLTWRTIGGVLDFYIFL Q4SML8_TETNG Q4SML8_TETNG ME-QANLYGAHPFYLLMEDG-GAAHGFFLLNSNAMDVSLQPAPALTWRTIGGILDFYLFL Q6XK24_MOUSE Q6XK24_MOUSE NEDGTNLYGVQTFFLCLEDNSGLSFGVFLMNSNAMEVTLQPTPAITYRTTGGILDFYVFL MGAL1_HUMAN MGAL1_HUMAN AY-KKNSYGVHPYYMALEED-GSAHGVLLLNSNAMDVTLQPTPALTYRTTGGILDFYIVL MATCH * ** :.::: :*:. * :.*.:*:*****:* *** *.:::*: **:**.*:.* CONSENSUS ?????NLYG?HPFYL?LEDG?G?AHGVFLLNSNAMDV?LQP?PAL?WR?TGGILD?Y?FL

O73632_COTJA O73632_COTJA GPDPQSVVQQYLDVVGFPFMPPYWALGFHLCRWGYSSTSTTRQAAANMSAGLFP------ A2AFL4_MOUSE A2AFL4_MOUSE GPEPKSVVQQYLDVVGYPFMPPYWGLGFHLCRWGYSSTAIVRQVVENMTRTHFP------ LYAG_MOUSE LYAG_MOUSE GPEPKSVVQQYLDVVGYPFMPPYWGLGFHLCRWGYSSTAIVRQVVENMTRTHFP------ LYAG_RAT LYAG_RAT GPEPKSVVQQYLDVVGYPFMPPYWGLGFHLCRWGYSSTAIVRQVVENMTRTHFP------ LYAG_BOVIN LYAG_BOVIN GPEPKSVVQQYLDVVGYPFMPPYWGLGFHLCRWGYSTSAITRQVVENMTRAYFP------ A6NFM4_HUMAN A6NFM4_HUMAN GPEPKSVVQQYLDVVGYPFMPPYWGLGFHLCRWGYSSTAITRQVVENMTRAHFP------ LYAG_HUMAN LYAG_HUMAN GPEPKSVVQQYLDVVGYPFMPPYWGLGFHLCRWGYSSTAITRQVVENMTRAHFP------ LYAG_PONAB LYAG_PONAB GPEPKSVVRQYLDVVGYPFMPPYWGLGFHLCRWGYSSTAITSQVVENMTRAHFP------ O73626_COTJA O73626_COTJA GPDPNMVIQQYQEVIGFPAMPPLWALGFHLCRWGYGSSNETWQTAKAMRNFQIP------ Q4SML8_TETNG Q4SML8_TETNG GPDPASVVGQYLEVVGRPAMPVYWALGYHLCRWGYGGTNATWETVRHLRNYGIPQVRFRP Q6XK24_MOUSE Q6XK24_MOUSE GNTPEQVVQEYLELIGRPALPSYWTLGFQLSRYDYXSLDNMKAVVERNRAAQLP------ MGAL1_HUMAN MGAL1_HUMAN GPTPELVTQQYTELIGRPAMIPYWALGFHLSRYGYQNDAEISSLYDAMVAAQIP------ MATCH * * * :* :::* * : * **::*.*:.* :* CONSENSUS GP?P??VVQQYL?V?G?P?MPPYW?LGFHLCRWGY????????????M?????P??????

O73632_COTJA O73632_COTJA ------------------LDVQWNDLDYMDAKRDFTYNKETFRDYPDMVHDFHQRGLHYV A2AFL4_MOUSE A2AFL4_MOUSE ------------------LDVQWNDLDYMDARRDFTFNQDSFADFPDMVRELHQDGRRYM LYAG_MOUSE LYAG_MOUSE ------------------LDVQWNDLDYMDARRDFTFNQDSFADFPDMVRELHQDGRRYM LYAG_RAT LYAG_RAT ------------------LDVQWNDLDYMDARRDFTFNQDGFADFPDMVHELHQGGRRYM LYAG_BOVIN LYAG_BOVIN ------------------LDVQWNDLDYMDARRDFTFNKDHFGDFPAMVQELHQGGRRYI A6NFM4_HUMAN A6NFM4_HUMAN ------------------LDVQWNDLDYMDSRRDFTFNKDGFRDFPAMVQELHQGGRRYM LYAG_HUMAN LYAG_HUMAN ------------------LDVQWNDLDYMDSRRDFTFNKDGFRDFPAMVQELHQGGRRYM LYAG_PONAB LYAG_PONAB ------------------LDVQWNDLDYMDARRDFTFNKDGFRDFPAMVRELHQGGRRYM O73626_COTJA O73626_COTJA ------------------QDAQWNDIDYMDGYRDFTFDPQKFASLPSLVEDLHKHGQHYV Q4SML8_TETNG Q4SML8_TETNG PSLGSVGSGKLKGWLVCGQDVQWNDIDYMDRKLDFTLDS-NFSSLPDMIADLHAHHQRYV Q6XK24_MOUSE Q6XK24_MOUSE ------------------YDVQHADIDYMDQKKDFTYDPVNFKGFPEFVKELHNNGQKLV MGAL1_HUMAN MGAL1_HUMAN ------------------YDVQHVDIDYMNRKLDFTLSA-NFQNLSLLIEQMKKNGMRFI MATCH *.* *:***: *** . * . . :: ::: : : CONSENSUS ???????????????????DVQWND?DYMD???DFT?????F???P??V??LH??G??Y?

O73632_COTJA O73632_COTJA MIVDPGISSSG-PPGTYRPYDDGLKRGVFIRNATGQ-PLIGKVWPGP------------- A2AFL4_MOUSE A2AFL4_MOUSE MIVDPAISSAG-PAGSYRPYDEGLRRGVFITNETGQ-PLIGKVWPGT------------- LYAG_MOUSE LYAG_MOUSE MIVDPAISSAG-PAGSYRPYDEGLRRGVFITNETGQ-PLIGKVWPGT------------- LYAG_RAT LYAG_RAT MIVDPAISSSG-PAGSYRPYDEGLRRGVFITNETGQ-PLIGKVWPGS------------- LYAG_BOVIN LYAG_BOVIN MIVDPAISSSG-PAGTYRPYDEGLRRGVFITNETGQ-PLIGQVWPGL------------- A6NFM4_HUMAN A6NFM4_HUMAN MIVDPAISSSG-PAGSYRPYDEGLRRGVFITNETGQ-PLIGKVWPGS------------- LYAG_HUMAN LYAG_HUMAN MIVDPAISSSG-PAGSYRPYDEGLRRGVFITNETGQ-PLIGKVWPGS------------- LYAG_PONAB LYAG_PONAB MIVDPAISSSG-PAGSYRPYDEGLRRGVFITNETSQ-PLIGKVWPGS------------- O73626_COTJA O73626_COTJA IILDPGISSTS-PRGSYWPFDEGLRRGLFLNTTQGQ-TLIGQVWPGY------------- Q4SML8_TETNG Q4SML8_TETNG LILDPGISSTQ-PEGSYWPYEDGMKRDVFIRDWEGN-VILGKVWPGL------------- Q6XK24_MOUSE Q6XK24_MOUSE IILDPAISNNSFSSNPYGPYDRGSAMKIWVNSSDGISPVIGKVWPGT------------- MGAL1_HUMAN MGAL1_HUMAN LILDPAISGN---ETQYLPFIRGQENNVFIKWPDTNDIVWGKVWPDLPNVIVDGSLDHET MATCH :*:**.**. * *: * ::: : *:***. CONSENSUS ?I?DP?ISS???P?G?Y?PYD?G??R?VFI????G????IGKVWPG??????????????

O73632_COTJA O73632_COTJA --------TAFPDFTNPETHEWWHDMVKDFHEQ-------VPFDGMWI------------ A2AFL4_MOUSE A2AFL4_MOUSE --------TAFPDFTNPETLDWWQDMVSEFHAQ-------VPFDGMWL------------ LYAG_MOUSE LYAG_MOUSE --------TAFPDFTNPETLDWWQDMVSEFHAQ-------VPFDGMWL------------ LYAG_RAT LYAG_RAT --------TAFPDFTNPETLDWWQDMVSEFHAQ-------VPFDGMWI------------ LYAG_BOVIN LYAG_BOVIN --------TAFPDFTNPETLDWWQDMVTEFHAQ-------VPFDGMWI------------ A6NFM4_HUMAN A6NFM4_HUMAN --------TAFPDFTNPTALAWWEDMVAEFHDQ-------VPFDGMWI------------ LYAG_HUMAN LYAG_HUMAN --------TAFPDFTNPTALAWWEDMVAEFHDQ-------VPFDGMWI------------ LYAG_PONAB LYAG_PONAB --------TAFPDFTNPAALAWWEDMVAEFHDQ-------VPFDGMWI------------ O73626_COTJA O73626_COTJA --------TAYPDFSNTDTHQWWLENLQRFHTH-------VPFDGLWI------------ Q4SML8_TETNG Q4SML8_TETNG --------TAYPDFSNAETHEWWYDSLKRFHQK-------VPFDGLWIVSTDAGGKKPLQ Q6XK24_MOUSE Q6XK24_MOUSE --------TVFPDYTSPNCAVWXTKEFELFHKE-------VEFDGIWI------------ MGAL1_HUMAN MGAL1_HUMAN QVKLYRAYVAFPDFFRNSTAAWWKKEIEELYANPREPEKSLKFDGLWI------------ MATCH ..:**: * . . :: . : ***:*: CONSENSUS ????????TAFPDF?N?????WW??????FH?????????VPFDG?WI????????????

O73632_COTJA O73632_COTJA --DMNEPSNFVEGSQDGCPDSSLEKPPYVPGVFGGR--LQAGTICASSQQYLSS-----H A2AFL4_MOUSE A2AFL4_MOUSE --DMNEPSNFVRGSQQGCPNNELENPPYVPGVVGGI--LQAATICASSHQFLST-----H LYAG_MOUSE LYAG_MOUSE --DMNEPSNFVRGSQQGCPNNELENPPYVPGVVGGI--LQAATICASSHQFLST-----H LYAG_RAT LYAG_RAT --DMNEPSNFIRGSQQGCPDNELENPPYVPGVVGGA--LQAATICASSHQFLST-----H LYAG_BOVIN LYAG_BOVIN --DMNEPSNFVRGSVDGCPDNSLENPPYLPGVVGGT--LRAATICASSHQFLST-----H A6NFM4_HUMAN A6NFM4_HUMAN --DMNEPSNFIRGSEDGCPNNELENPPYVPGVVGGT--LQAATICASSHQFLST-----H LYAG_HUMAN LYAG_HUMAN --DMNEPSNFIRGSEDGCPNNELENPPYVPGVVGGT--LQAATICASSHQFLST-----H LYAG_PONAB LYAG_PONAB --DMNEPSNFIRGSEDGCPDNELENPPYVPGVVGGT--LQAATICASSHQFLST-----H O73626_COTJA O73626_COTJA --DMNEPSNFMDGSEEGCPPGELDSPPYTPAVLGNS--LTAKTVCASAEQNASV-----H Q4SML8_TETNG Q4SML8_TETNG KKDMNEPSNFLEGSTKGCPSTSLENPPYTPGILGGS--LKSKTLCASAQQKLSS-----H Q6XK24_MOUSE Q6XK24_MOUSE --DMNEVSNFIDGSFSGCSQNNLNXPPFTPKVLD-------------------------- MGAL1_HUMAN MGAL1_HUMAN --DMNEPSNFVDGSVRGCSNEMLNNPPYMPYLESRDKGLSSKTLCMESQQILPDSSPVEH MATCH **** ***: ** **. *: **: * : . CONSENSUS ??DMNEPSNF??GS??GCP???L??PPY?P?V?G????L???T?CAS??Q?LS??????H

O73632_COTJA O73632_COTJA YNLHSLYGLTEAIASHNALLRVRGTRPFVISRSTFAGHGHYAGHWTGDVESSWEQLAHSV A2AFL4_MOUSE A2AFL4_MOUSE YNLHNLYGLTEAIASSRALVKTRGTRPFVISRSTFSGHGRYAGHWTGDVRSSWEHLAYSV LYAG_MOUSE LYAG_MOUSE YNLHNLYGLTEAIASSRALVKTRGTRPFVISRSTFSGHGRYAGHWTGDVRSSWEHLAYSV LYAG_RAT LYAG_RAT YNLHNLYGLTEAIASSRALVKTRGTRPFVISRSTFAGHGRYAGHWTGDVWSSWEHLAYSV LYAG_BOVIN LYAG_BOVIN YDLHNLYGLTEALASHRALVKARGMRPFVISRSTFAGHGRYSGHWTGDVWSNWEQLSYSV A6NFM4_HUMAN A6NFM4_HUMAN YNLHNLYGLTEAIASHRALVKARGTRPFVISRSTFAGHGRYAGHWTGDVWSSWEQLASSV LYAG_HUMAN LYAG_HUMAN YNLHNLYGLTEAIASHRALVKARGTRPFVISRSTFAGHGRYAGHWTGDVWSSWEQLASSV LYAG_PONAB LYAG_PONAB YNLHNLYGLTEAIASHRALVKARGTRPFVISRSTFAGHGRYAGHWTGDVWSSWEQLASSV O73626_COTJA O73626_COTJA YNLHNLYGLKEAEATASALIRIRGKRPFVISRSTFPSQGRYSGHWLGDNRSQWKDMYYSI Q4SML8_TETNG Q4SML8_TETNG YNLHNLYGLMEAQATASALKRIVPKRPFVLSRSTFPGQGMYSGHWLGDNKSRWKDMYTSI Q6XK24_MOUSE Q6XK24_MOUSE ------------------------------------------------------------ MGAL1_HUMAN MGAL1_HUMAN YNVHNLYGWSQTRPTYEAVQEVTGQRGVIITRSTFPSSGRWGGHRLGNNTAAWDQLGKSI MATCH CONSENSUS YNLHNLYGL?EA?A???AL????G?RPFVISRSTF???G?Y?GHW?GD??S?W?????S?

O73632_COTJA O73632_COTJA PEVLLFNLLGVPLVGADICGFAGDTSEELCVRWTQLGTFYPFMRNHNDHGNRPQEPYAFS A2AFL4_MOUSE A2AFL4_MOUSE PDILQFNLLGVPLVGADICGFIGDTSEELCVRWTQLGAFYPFMRNHNDLNSVPQEPYRFS LYAG_MOUSE LYAG_MOUSE PDILQFNLLGVPLVGADICGFIGDTSEELCVRWTQLGAFYPFMRNHNDLNSVPQEPYRFS LYAG_RAT LYAG_RAT PEILQFNLLGVPLVGADICGFQGNTTEELCVRWTQLGAFYPFMRNHNDLNSLPQEPYRFS LYAG_BOVIN LYAG_BOVIN PEILLFNLLGVPLVGADICGFLGNTSEELCVRWTQLGAFYPFMRNHNALNSQPQEPYRFS A6NFM4_HUMAN A6NFM4_HUMAN PEILQFNLLGVPLVGADVCGFLGNTSEELCVRWTQLGAFYPFMRNHNSLLSLPQEPYSFS LYAG_HUMAN LYAG_HUMAN PEILQFNLLGVPLVGADVCGFLGNTSEELCVRWTQLGAFYPFMRNHNSLLSLPQEPYSFS LYAG_PONAB LYAG_PONAB PEILQFNLLGVPLVGADVCGFLGNTSEELCVRWTQLGAFYPFMRNHNGLLNLPQEPYSFS O73626_COTJA O73626_COTJA PGMLSFSLFGIPLVGADICGFSGSTSEELCTRWMQLGAFYPFSRNHNNQNEKAQDPTAFS Q4SML8_TETNG Q4SML8_TETNG AGMLTFNLLGIPLVGADICGFQEDTQEELCVRWTQLGAFYPFTRNHNDLSSKAQDPTVFS Q6XK24_MOUSE Q6XK24_MOUSE ------------------------------------------------------------ MGAL1_HUMAN MGAL1_HUMAN IGMMEFSLFGIPYTGADICGFFGDAEYEMCVRWMQLGAFYPFSRNHNNIGTRRQDPVAWN MATCH CONSENSUS ???L?F?L?G?PLVGAD?CGF?G?T?EELCVRW?QLGAFYPF?RNHN??????Q?P??FS

O73632_COTJA O73632_COTJA LPAQDAMRSALRLRYSLLPYLYTLFHRAHMAGDTVARPLFLEFPKDPNTWIVDRQLLWGA A2AFL4_MOUSE A2AFL4_MOUSE ETAQQAMRKAFALRYALLPYLYTLFHRAHVRGDTVARPLFLEFPEDPSTWSVDRQLLWGP LYAG_MOUSE LYAG_MOUSE ETAQQAMRKAFALRYALLPYLYTLFHRAHVRGDTVARPLFLEFPEDPSTWSVDRQLLWGP LYAG_RAT LYAG_RAT ETAQQAMRKAFTLRYALLPYLYTLFHGAHVKGDTVARPLFLEFPEDPSTWSVDRQLLWGP LYAG_BOVIN LYAG_BOVIN ETAQQAMRKAFTLRYVLLPYLYTLFHRAHVRGETVARPLFLEFPEDPSTWTVDRQLLWGE A6NFM4_HUMAN A6NFM4_HUMAN EPAQQAMRKALTLRYALLPHLYTLFHQAHVAGETVARPLFLEFPKDSSTWTVDHQLLWGE LYAG_HUMAN LYAG_HUMAN EPAQQAMRKALTLRYALLPHLYTLFHQAHVAGETVARPLFLEFPKDSSTWTVDHQLLWGE LYAG_PONAB LYAG_PONAB EPAQQAMRKALTLRYALLPHLYTLFHQAHVAGETVARPLFLEFPKDSSTWTVDHQLLWGE O73626_COTJA O73626_COTJA PSARTAMKDALLTRYSLLPFLYTLFHRAHLQGETVARPLFFEFPWDVATYGLDRQFLWGQ Q4SML8_TETNG Q4SML8_TETNG PLARTAMRDALLLRYSLFPLLYTLFHHAHVKGHTVARPLMFEFPKDVRTYGIDRQFLWGR Q6XK24_MOUSE Q6XK24_MOUSE ------------------------------------------------------------ MGAL1_HUMAN MGAL1_HUMAN STFEMLSRKVLETRYTLLPYLYTLMHKAHVEGSTVVRPLLHEFTDDRTTWDIDRQFMLGP MATCH CONSENSUS ??A??AMR?A???RY?LLP?LYTLFH?AH??G?TVARPL??EFP?D??T???D?Q?LWG?

O73632_COTJA O73632_COTJA GLLITPVLEQGQTKVSGYFPAGTWYSFTG------------------DSTIHSKGQWILL A2AFL4_MOUSE A2AFL4_MOUSE ALLITPVLEPGKTEVTGYFPKGTWYNMQMVSVDSLGTLPSPSSASSFRSAVQSKGQWLTL LYAG_MOUSE LYAG_MOUSE ALLITPVLEPGKTEVTGYFPKGTWYNMQMVSVDSLGTLPSPSSASSFRSAVQSKGQWLTL LYAG_RAT LYAG_RAT ALLITPVLEPGKTDVTGYFPKGMWYNLQMVPVETLGSLPSSSPASSFRSIVHSKGQWLTL LYAG_BOVIN LYAG_BOVIN ALLITPVLEAEKVEVTGYFPQGTWYDLQTVPMEAFGSLPPP---APLTSVIHSKGQWVTL A6NFM4_HUMAN A6NFM4_HUMAN ALLITPVLQAGKAEVTGYFPLGTWYDLQTVPVEALGSLPPP-PAAPREPAIHSEGQWVTL LYAG_HUMAN LYAG_HUMAN ALLITPVLQAGKAEVTGYFPLGTWYDLQTVPIEALGSLPPP-PAAPREPAIHSEGQWVTL LYAG_PONAB LYAG_PONAB ALLITPVLQAGKAEVTGYFPLGIWYDLQTVPIEALGSLPPP-PAAPREPAIHSEGQWVTL O73626_COTJA O73626_COTJA SLLVTPVLEPGADSVLGYFPQGVWYDFYT------------------GSSVNSSGEMLKL Q4SML8_TETNG Q4SML8_TETNG SLLVTPVLDPGVDHVVGYFPEGLWYDYYT------------------GDSIRSKGEEVNL Q6XK24_MOUSE Q6XK24_MOUSE ------------------------------------------------------------ MGAL1_HUMAN MGAL1_HUMAN AILISPVLETSTFEISAYFPRARWYDYST------------------GTSSTSTGQRKIL MATCH CONSENSUS ?LL?TPVL??????V?GYFP?G?WY???????????????????????????S?G????L

O73632_COTJA O73632_COTJA AAPLDTINVHIRAGHILPLQEPGLNTAESRKKGMMVVVALTPDGFARGELFWDDGESWQS A2AFL4_MOUSE A2AFL4_MOUSE EAPLDTINVHLREGYIIPLQGPSLTTTESRKQPMALAVALTASGEADGELFWDDGESLAV LYAG_MOUSE LYAG_MOUSE EAPLDTINVHLREGYIIPLQGPSLTTTESRKQPMALAVALTASGEADGELFWDDGESLAV LYAG_RAT LYAG_RAT EAPLDTINVHLRAGYIIPLQGPSLTTTESRKQPMALAVALTESGEASGELFWDDGESLGV LYAG_BOVIN LYAG_BOVIN SAPLDTINVHLRAGHIIPMQGPALTTTESRKQHMALAVALTASGEAQGELFWDDGESLGV A6NFM4_HUMAN A6NFM4_HUMAN PAPLDTINVHLRAGYIIPLQGPGLTTTESRQQPMALAVALTKGGEARGELFWDDGESLEV LYAG_HUMAN LYAG_HUMAN PAPLDTINVHLRAGYIIPLQGPGLTTTESRQQPMALAVALTKGGEARGELFWDDGESLEV LYAG_PONAB LYAG_PONAB PAPLDTINVHLRAGYIIPLQGPGLTTTESRQQPMALAVALTKGGEARGELFWDDGESLEV O73626_COTJA O73626_COTJA SAPLDHLNLHLREGSILPTQKPGITSKATRGNPLHLIVALSTRATAWGDLFWDDGESLDT Q4SML8_TETNG Q4SML8_TETNG HAPLDKLNLHLREGSVTPTQ---------------------------------------- Q6XK24_MOUSE Q6XK24_MOUSE -------------GY--------------------------------------------- MGAL1_HUMAN MGAL1_HUMAN KAPLDHINLHVRGGYILPWQEPAMNTHSSRQNFMGLIVALDDNGTAEGQVFWDDGQSI-- MATCH * CONSENSUS ?APLD??N?H?R?G?I?P?Q?P???????R???????VAL?????A?G??FWDDG?S???

O73632_COTJA O73632_COTJA FEKGDCTEILFLAARGAVLSQILRAGGHLDGILVEAVTVLGVPSAPQRVLANGIPVEDFS A2AFL4_MOUSE A2AFL4_MOUSE LERGAYTLVTFSAKNNTIVNKLVRVTKEGAELQLREVTVLGVATAPTQVLSNGIPVSNFT LYAG_MOUSE LYAG_MOUSE LERGAYTLVTFSAKNNTIVNKLVRVTKEGAELQLREVTVLGVATAPTQVLSNGIPVSNFT LYAG_RAT LYAG_RAT LERGAYTLVTFSAKNNTIVNKLVHVTKEGGELQLREVTILGVTTAPTQVLSNGISVSNFT LYAG_BOVIN LYAG_BOVIN LDGGDYTQLIFLAKNNTFVNKLVHVSSEGASLQLRNVTVLGVATAPQQVLCNSVPVSNFT A6NFM4_HUMAN A6NFM4_HUMAN LERGAYTQVIFLARNNTIVNELVRVTSEGAGLQLQKVTVLGVATAPQQVLSNGVPVSNFT LYAG_HUMAN LYAG_HUMAN LERGAYTQVIFLARNNTIVNELVRVTSEGAGLQLQKVTVLGVATAPQQVLSNGVPVSNFT LYAG_PONAB LYAG_PONAB LERGAYTQVLFLARNNTIVNELVHVTSEGAGLQLQKVTVLGVATTPQQVLSNGVPVSNFT O73626_COTJA O73626_COTJA FEQGNYSYLVFNATENIFTSNVLHASTEATDVTIDAVSFYGVQEPPSKVLLDG-QEKPFS Q4SML8_TETNG Q4SML8_TETNG ---------------NTMTSTVLHSNVEASYITVETASFYGVKQRPSRVLVNS-QEAVFS Q6XK24_MOUSE Q6XK24_MOUSE ------------------------------------------------------------ MGAL1_HUMAN MGAL1_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????GV???P??VL????????F?

O73632_COTJA O73632_COTJA YRSDTQVLRVS-VSLPMWEQFVVPWS A2AFL4_MOUSE A2AFL4_MOUSE YSPDNKSLAIP-VSLLMGELFQISWS LYAG_MOUSE LYAG_MOUSE YSPDNKSLAIP-VSLLMGELFQISWS LYAG_RAT LYAG_RAT YSPDDKSLSIP-VSLLMGERFQIDWS LYAG_BOVIN LYAG_BOVIN FSPDTETLAIP-VSLTMGEQFVISWS A6NFM4_HUMAN A6NFM4_HUMAN YSPDTKVLDIC-VSLLMGEQFLVSWC LYAG_HUMAN LYAG_HUMAN YSPDTKVLDIC-VSLLMGEQFLVSWC LYAG_PONAB LYAG_PONAB YSPDTKVLDIP-VSLLMAEQFLISWS O73626_COTJA O73626_COTJA YL-DNQVLTVSGLGLVLSQGFSLQWL Q4SML8_TETNG Q4SML8_TETNG YR-DNQVMTVADLGLKLSQNFTISWV Q6XK24_MOUSE Q6XK24_MOUSE -------------------------- MGAL1_HUMAN MGAL1_HUMAN -------------------VFNTTAM MATCH CONSENSUS ???D??????????L?????F???W?


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