Alignment of the gene Family HBG006399 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
Q4T7V9_TETNG Q4T7V9_TETNG AVQPKQNLSMDSAAETGFVNFLLSMPEKPDTTFRVFDRNDFYTVHGKDAIYAAKEVFKTN Q803R6_DANRE Q803R6_DANRE AVQPKQNLSMDSASEHGFLNFYFSMSDKPDTTVRVFDRNDYYTVHGKDAIFAAKEVFKTN Q90XA7_DANRE Q90XA7_DANRE AVQPKQNLSMDSASEHGFLNFYFSMSDKPDTTVRVFDRNDYYTVHGKDAIFAAKEVFKTN MSH2_BOVIN MSH2_BOVIN AVQPKDTLQLDSAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHREDALLAAREVFKTQ Q5SBJ2_CANFA Q5SBJ2_CANFA ------------------------------------------------------------ MSH2_CERAE MSH2_CERAE AVQPKETLQLESAAEVGFVRFFQSMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQ Q4R336_MACFA Q4R336_MACFA ------------------------------------------------------------ B4DN49_HUMAN B4DN49_HUMAN AVQPKETLRLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQ B4DSB9_HUMAN B4DSB9_HUMAN ------------------------------------------------------------ B4DL39_HUMAN B4DL39_HUMAN ------------------------------------------------------------ B4E2Z2_HUMAN B4E2Z2_HUMAN ------------------------------------------------------------ Q53GS1_HUMAN Q53GS1_HUMAN AVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQ MSH2_HUMAN MSH2_HUMAN AVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQ Q53FK0_HUMAN Q53FK0_HUMAN AVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQ Q5R4H9_PONAB Q5R4H9_PONAB AVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQ Q53RU4_HUMAN Q53RU4_HUMAN AVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQ MSH2_MOUSE MSH2_MOUSE AVQPKETLQLEGAAEAGFVRFFEGMPEKPSTTVRLFDRGDFYTAHGEDALLAAREVFKTQ Q3TZI5_MOUSE Q3TZI5_MOUSE AVQPKETLQLEGAAEAGFVRFFEGMPEKPSTTVRLFDRGDFYTAHGEDALLAAREVFKTQ Q80V79_MOUSE Q80V79_MOUSE AVQPKETLQLEGAAEAGFVRFFEGMPEKPSTTVRLFDRGDFYTAHGEDALLAAREVFKTQ B2DD05_MESAU B2DD05_MESAU AVQPKETLQLEGAAEAAFVRFFEGMPEKPSTTVRLFDRGDFYTAHGEDALLAAREVFKTQ B1WBQ7_RAT B1WBQ7_RAT AVQPKETLQLEGAAEVGFVRFFEGMPEKPSTTVRLFDRGDFYTAHGEDALLAAREVFKTQ MSH2_RAT MSH2_RAT AVQPKETLQLEGAAEVGFVRFFEGMPEKPSTTVGLFDRGDFYTAHGEDALLAAREVFKTQ Q5HZF7_XENLA Q5HZF7_XENLA ------------------------------------------------------------ Q76FQ4_CHICK Q76FQ4_CHICK ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4T7V9_TETNG Q4T7V9_TETNG GVIKYLG-SGSRRLESVVLSKPNFEALARDLLLVRQYRVEVYKNQNQSKSSKEQDWKLEF Q803R6_DANRE Q803R6_DANRE GVIKNLG-SGNRRLESVVLSKMNFESFVRDLLLVRQYRVEVYKN--ASKSSKEHDWQIAF Q90XA7_DANRE Q90XA7_DANRE GVIKNLG-SGNRRLESVVLSKMNFESFVRDLLLVRQYRVEVYKN--ASKSSKEHDWQIAF MSH2_BOVIN MSH2_BOVIN GVVKYMGPAGAKTLESVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAF Q5SBJ2_CANFA Q5SBJ2_CANFA ------------------------------------------------------------ MSH2_CERAE MSH2_CERAE GVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAY Q4R336_MACFA Q4R336_MACFA -----MGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVY------------------ B4DN49_HUMAN B4DN49_HUMAN GVIKYMGPAGAKNLQSVV------------------------------------------ B4DSB9_HUMAN B4DSB9_HUMAN -------MIGIWHIRLLLAISLSLKTFSLVTM---------------------------- B4DL39_HUMAN B4DL39_HUMAN ------------------------------------------------------------ B4E2Z2_HUMAN B4E2Z2_HUMAN -----MGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAY Q53GS1_HUMAN Q53GS1_HUMAN GVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAY MSH2_HUMAN MSH2_HUMAN GVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAY Q53FK0_HUMAN Q53FK0_HUMAN GVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAY Q5R4H9_PONAB Q5R4H9_PONAB GVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAY Q53RU4_HUMAN Q53RU4_HUMAN GVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAY MSH2_MOUSE MSH2_MOUSE GVIKYMGPAGSKTLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNKAGNKASKENEWYLAF Q3TZI5_MOUSE Q3TZI5_MOUSE GVIKYMGPAGSKTLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNKAGNKASKENEWYLAF Q80V79_MOUSE Q80V79_MOUSE GVIKYMGPAGSKTLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNKAGNKASKENEWYLAF B2DD05_MESAU B2DD05_MESAU GVIKYLGPAGAKTLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNKAGNKASKENDWYLAY B1WBQ7_RAT B1WBQ7_RAT GVIKYMGPAGAKTLQTVVLSKMNFESFVKDLLLVRHYRVEVYKNKAGNKASKENDWYLAY MSH2_RAT MSH2_RAT GVIKYMGPAGAKTLQTVVLSKMNFESFVKDLLLVRHYRVEVYKNKAGNKASKENDWYLAY Q5HZF7_XENLA Q5HZF7_XENLA ------------------------------------------------------------ Q76FQ4_CHICK Q76FQ4_CHICK -----------QKLESVVLSKMNFESFVRDLLLVRHYRVEVYKNKAGSKSVKENDWYLAY MATCH CONSENSUS ?????????G???L??VV??????????????????????????????????????????

Q4T7V9_TETNG Q4T7V9_TETNG KASPGNLTQFEEVLFGSGSG-SEACAGVVAVRVAAGADGQRVVGLGYVDAAQRMMGVCEF Q803R6_DANRE Q803R6_DANRE KASPGNLTQFEEILFGSGGGPAEGAVGVVGVRLGTGTDGQRVVGVGYVDSTLRKLGVCEF Q90XA7_DANRE Q90XA7_DANRE KASPGNLTQFEEILFGSGGGPAEGAVGVVGVRLGTGTDGQRVVGVGYVDSTLRKLGVCEF MSH2_BOVIN MSH2_BOVIN KASPGNLSQFEDILFGNND--MSASIGVVGVKMST-VDGQRQVGVGYVDSTQRKLGLCEF Q5SBJ2_CANFA Q5SBJ2_CANFA ------------------------------------------------------------ MSH2_CERAE MSH2_CERAE KASPGNLSQFEDILFGNND--MSASIGVVGVKMST-VDGQRQVGVGYVDSTQRKLGLCEF Q4R336_MACFA Q4R336_MACFA ------------------------------------------------------------ B4DN49_HUMAN B4DN49_HUMAN -----------------------------GVKMSA-VDGQRQVGVGYVDSIQRKLGLCEF B4DSB9_HUMAN B4DSB9_HUMAN --------------------------------------------------------ICQL B4DL39_HUMAN B4DL39_HUMAN ------------------------------------------------------------ B4E2Z2_HUMAN B4E2Z2_HUMAN KASPGNLSQFEDILFGNND--MSASIGVVGVKMSA-VDGQRQVGVGYVDSIQRKLGLCEF Q53GS1_HUMAN Q53GS1_HUMAN KASPGNLSQFEDILFGNND--MSASIGVVGVKMSA-VDGQRQVGVGYVDSIQRKLGLCEF MSH2_HUMAN MSH2_HUMAN KASPGNLSQFEDILFGNND--MSASIGVVGVKMSA-VDGQRQVGVGYVDSIQRKLGLCEF Q53FK0_HUMAN Q53FK0_HUMAN KASPGNLSQFEDILFGNND--MSASIGVVGVKMSA-VDGQRQVGVGYVDSIQRKLGLCEF Q5R4H9_PONAB Q5R4H9_PONAB KASPGNLSQFEDILFGNND--MSASIGVVGVKMSA-VDGQRQVGVGYVDSIQRKLGLCEF Q53RU4_HUMAN Q53RU4_HUMAN KASPGNLSQFEDILFGNND--MSASIGVVGVKMSA-VDGQRQVGVGYVDSIQRKLGLCEF MSH2_MOUSE MSH2_MOUSE KASPGNLSQFEDILFGNND--MSASVGVMGIKMAV-VDGQRHVGVGYVDSTQRKLGLCEF Q3TZI5_MOUSE Q3TZI5_MOUSE KASPGNLSQFEDILFGNND--MSASVGVMGIKMAV-VDGQRHVGVGYVDSTQRKLGLCEF Q80V79_MOUSE Q80V79_MOUSE KASPGNLSQFEDILFGNND--MSASVGVMGIKMAV-VDGQRHVGVGYVDSTQRKLGLCEF B2DD05_MESAU B2DD05_MESAU KASPGNLSQFEDILFGNND--MSDSVGIVGVKMSM-VDGQRHVGVGYVDSIQRKLGLCEF B1WBQ7_RAT B1WBQ7_RAT KASPGNLSQFEDILFGNND--MSTSIGIMGIKLST-VDGQRQVGVGYVDSTQRKLGLCEF MSH2_RAT MSH2_RAT KASPGNLSQFEDILFGNND--MATSIGIMGIKLST-VDGQRQVGVGDVDSTQRKLGLCEF Q5HZF7_XENLA Q5HZF7_XENLA ------------------------------------------------------------ Q76FQ4_CHICK Q76FQ4_CHICK KGSPGNLAQFEEVLFANND--MSMAIGVVGVKLSS-ADGQRVIGVGYVDTTLRKLSVCEF MATCH CONSENSUS ?????????????????????????????????????????????????????????C??

Q4T7V9_TETNG Q4T7V9_TETNG PDNETFSNLESLLVQIGPKECLLVQGEGSAEGSKLREVVQRGGVLVSERKKAEFNSKDLV Q803R6_DANRE Q803R6_DANRE PDNDQFSNLEALLVQIGPKECVLPAGDSGGDQGKLKQVVQRGGILLTDRKKSEFTTKDIV Q90XA7_DANRE Q90XA7_DANRE PDNDQFSNLEALLVQIGPKECVLPAGDSGGDLGKLKQVVQRGGILLTDRKKSEFTTKDIV MSH2_BOVIN MSH2_BOVIN PDNDQFSNLEALLIQIGPKECVMPGGETAGDMGKLRQVIQRGGILITERKRADFSTKDIY Q5SBJ2_CANFA Q5SBJ2_CANFA ------------------------------------------------------------ MSH2_CERAE MSH2_CERAE PDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIY Q4R336_MACFA Q4R336_MACFA ------------------------------------------------------------ B4DN49_HUMAN B4DN49_HUMAN PDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIY B4DSB9_HUMAN B4DSB9_HUMAN P--------LVLWVLKCPQLM-------ARDMGKLRQIIQRGGILITERKKADFSTKDIY B4DL39_HUMAN B4DL39_HUMAN ------------------------------------------------------------ B4E2Z2_HUMAN B4E2Z2_HUMAN PDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIY Q53GS1_HUMAN Q53GS1_HUMAN PDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIY MSH2_HUMAN MSH2_HUMAN PDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIY Q53FK0_HUMAN Q53FK0_HUMAN PDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIY Q5R4H9_PONAB Q5R4H9_PONAB PDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIY Q53RU4_HUMAN Q53RU4_HUMAN PDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIY MSH2_MOUSE MSH2_MOUSE PENDQFSNLEALLIQIGPKECVLPGGETTGDMGKLRQVIQRGGILITERKRADFSTKDIY Q3TZI5_MOUSE Q3TZI5_MOUSE PENDQFSNLEALLIQIGPKECVLPGGETTGDMGKLRQVIQRGGILITERKRADFSTKDIY Q80V79_MOUSE Q80V79_MOUSE PENDQFSNLEALLIQIGPKECVLPGGETTGDMGKLRQVIQRGGILITERKRADFSTKDIY B2DD05_MESAU B2DD05_MESAU PDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQVIQRGGILITERKRADFSTKDIC B1WBQ7_RAT B1WBQ7_RAT PDNDQFSNLEALLIQIGPKECILPGGETAGDMGKLRQVIQRGGILITERKRIDFSTKDIY MSH2_RAT MSH2_RAT PDNDQFSNLEALLIQIGPKECILPGGETAGDMGKLRQVIQRGGILITERKRIDFSTKDIY Q5HZF7_XENLA Q5HZF7_XENLA ------------------------------------------------------------ Q76FQ4_CHICK Q76FQ4_CHICK PDNDQFSNLEALLVQLGPKECVLPGGDTAGEMGKLRQVVQRGGILITDRKKADFTTKDIV MATCH CONSENSUS P??????????L?????P???????????????KL????QRGG?L???RK???F??KD??

Q4T7V9_TETNG Q4T7V9_TETNG QDLNRLLRTRKGQAASSGTLPELEKQVAVSCLAAAVRFLELLSDESNFGSFSLSSLDLAQ Q803R6_DANRE Q803R6_DANRE QDLNRLLKARKGETVSSAALPEMEKKIAMSCLEAVIKYLELLADEANFGSFKMTTFDLNQ Q90XA7_DANRE Q90XA7_DANRE QDLNRLLKARKGETVSSAALPEMEKKIAMSCLEAVIRYLELLADEANFGSFKMTTFDLNQ MSH2_BOVIN MSH2_BOVIN QDLNRLLKGKKGEQVNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQ Q5SBJ2_CANFA Q5SBJ2_CANFA ----------------------------VSSLSAVIKFLELLSDDSNFGQYELTTFDFSQ MSH2_CERAE MSH2_CERAE QDLNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQ Q4R336_MACFA Q4R336_MACFA ------------------------------------------------------------ B4DN49_HUMAN B4DN49_HUMAN QDLNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQ B4DSB9_HUMAN B4DSB9_HUMAN QDLNRLLKGKKGEQMNSAVLPEMEN----------------------------------- B4DL39_HUMAN B4DL39_HUMAN --------------MNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQ B4E2Z2_HUMAN B4E2Z2_HUMAN QDLNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQ Q53GS1_HUMAN Q53GS1_HUMAN QDLNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQ MSH2_HUMAN MSH2_HUMAN QDLNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQ Q53FK0_HUMAN Q53FK0_HUMAN QDLNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQ Q5R4H9_PONAB Q5R4H9_PONAB QDLNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQ Q53RU4_HUMAN Q53RU4_HUMAN QDLNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQ MSH2_MOUSE MSH2_MOUSE QDLNRLLKGKKGEQINSAALPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELATFDFSQ Q3TZI5_MOUSE Q3TZI5_MOUSE QDLNRLLKGKKGEQINSAALPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELATFDFSQ Q80V79_MOUSE Q80V79_MOUSE QDLNRLLKGKKGEQINSAALPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELATFDFSQ B2DD05_MESAU B2DD05_MESAU QDLNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSYFGQFELTTFDFSQ B1WBQ7_RAT B1WBQ7_RAT QDLNRLLKGRKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELATFDFSQ MSH2_RAT MSH2_RAT QDLNRLLKGRKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELATFDFSQ Q5HZF7_XENLA Q5HZF7_XENLA -------------------LPEMEKQVAMSALAAVMKYLELLSDESNFGQFVMTNFDLSQ Q76FQ4_CHICK Q76FQ4_CHICK QDLNRLLKSRKGEQMNSAALPEMEKQVAVSSLSAVIKFLELLSDDSNFGQYELTTFDLSQ MATCH CONSENSUS QDLNRLL???KG????SA?LPEME???A?S?L?AVIK?LELLSD?SNFG?F???TFD??Q

Q4T7V9_TETNG Q4T7V9_TETNG YMRLDNAAVRALNLFQGSPGDAAGTHSLAGLLNKCRTPQGQRLLHQWIKQPLLDTTRIEE Q803R6_DANRE Q803R6_DANRE YMRLDNAAVQALNLFQGSSDDATGTHSLAGLLNKCRTPQGQRLVNQWIKQPLIDKNKIEE Q90XA7_DANRE Q90XA7_DANRE YMRLDNAAVQALNLFQGSCDDATGTHSLAGLLNKCRTPQGQRLVNQWIKQPLIDKNKIEE MSH2_BOVIN MSH2_BOVIN YMKLDIAAVRALNLFQGSVEDTSGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEE Q5SBJ2_CANFA Q5SBJ2_CANFA YMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEE MSH2_CERAE MSH2_CERAE YMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEE Q4R336_MACFA Q4R336_MACFA ------------------------------------------------------KNRIEE B4DN49_HUMAN B4DN49_HUMAN YMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEE B4DSB9_HUMAN B4DSB9_HUMAN ---------------QGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEE B4DL39_HUMAN B4DL39_HUMAN YMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEE B4E2Z2_HUMAN B4E2Z2_HUMAN YMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEE Q53GS1_HUMAN Q53GS1_HUMAN YMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEE MSH2_HUMAN MSH2_HUMAN YMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEE Q53FK0_HUMAN Q53FK0_HUMAN YMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEE Q5R4H9_PONAB Q5R4H9_PONAB YMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEE Q53RU4_HUMAN Q53RU4_HUMAN YMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEE MSH2_MOUSE MSH2_MOUSE YMKLDMAAVRALNLFQGSVEDTTGSQSLAALLNKCKTAQGQRLVNQWIKQPLMDRNRIEE Q3TZI5_MOUSE Q3TZI5_MOUSE YMKLDMAAVRALNLFQGSVEDTTGSQSLAALLNKCKTAQGQRLVNQWIKQPLMDRNRIEE Q80V79_MOUSE Q80V79_MOUSE YMKLDMAAVRALNLFQGSVEDTTGSQSLAALLNKCKTAQGQRLVNQWIKQPLMDRNRIEE B2DD05_MESAU B2DD05_MESAU YMRLDMAAVRALNLFQGSVEDTTGSQSLAALLNKCKTAQGQRLVNQWIKQPLMDKNRIEE B1WBQ7_RAT B1WBQ7_RAT YMKLDMAAVRALNLFQGSVEDTTGSQSLAALLNKCKTAQGQRLVSQWIKQPLMDKNRIEE MSH2_RAT MSH2_RAT YMKLDMAAVRALNLFQGSVEDTTGSQSLAAFLNKCKTAQGQRLVSQWIKQPLMDKNRIEE Q5HZF7_XENLA Q5HZF7_XENLA YMKLDNAAVGALNLFPGSAEDTSGTQSLAGLLNKCKTPQGQRLVNQWIKQPLMDKNRVEE Q76FQ4_CHICK Q76FQ4_CHICK YMVLDNAAVQALNLFQSSVENANNTQSLAGLLNKCRTPQGQRLVNQWIKQPLMDKNRIEE MATCH .::** CONSENSUS YM?LD?AAV?ALNLFQGS?ED??G?QSLA?LLNKC?T?QGQRLVNQWIKQPLMDKNRIEE

Q4T7V9_TETNG Q4T7V9_TETNG RLDLVESLVSDSELRQTCQEDLLRRFPDLHRLSKKLHRQSATLQDCYRVYQAVGHIPALV Q803R6_DANRE Q803R6_DANRE RLDLVETFVEDSELRKSCQEDLLRRFPDLNRMAKKFQRQSSNLQDCYRVYQSVGQLPNVV Q90XA7_DANRE Q90XA7_DANRE RLDLVETFVEDSELRKSCQEDLLRRFPDLNRMAKKFQRQSSNLQDCYRVYQSVGQLPNVV MSH2_BOVIN MSH2_BOVIN RLNLVEAFVEDAELRQNLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVI Q5SBJ2_CANFA Q5SBJ2_CANFA RLNLVEAFVEDAELRQSLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVI MSH2_CERAE MSH2_CERAE RLNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVI Q4R336_MACFA Q4R336_MACFA RLNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVI B4DN49_HUMAN B4DN49_HUMAN RLNLVEAFVEDAELSQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVI B4DSB9_HUMAN B4DSB9_HUMAN RLNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVI B4DL39_HUMAN B4DL39_HUMAN RLNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVI B4E2Z2_HUMAN B4E2Z2_HUMAN RLNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVI Q53GS1_HUMAN Q53GS1_HUMAN RLNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVI MSH2_HUMAN MSH2_HUMAN RLNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVI Q53FK0_HUMAN Q53FK0_HUMAN RLNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVI Q5R4H9_PONAB Q5R4H9_PONAB RLNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVI Q53RU4_HUMAN Q53RU4_HUMAN RLNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVI MSH2_MOUSE MSH2_MOUSE RLNLVEAFVEDSELRQSLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPSVI Q3TZI5_MOUSE Q3TZI5_MOUSE RLNLVEAFVEDSELRQSLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPSVI Q80V79_MOUSE Q80V79_MOUSE RLNLVEAFVEDSELRQSLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPSVI B2DD05_MESAU B2DD05_MESAU RLNLVEAFAEDSELRQTLQEDLLRRFPDLNRLAKKFQRQAANLHDCYRLYQGVNQLPSVI B1WBQ7_RAT B1WBQ7_RAT RLNLVEAFVEDSELRQSLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGVNQLPNVI MSH2_RAT MSH2_RAT RLNLVEAFVEDSELRRALQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGVKQLPNVI Q5HZF7_XENLA Q5HZF7_XENLA RLNLVEAFVMDVELRQCLQEDLLRRFPDLNRLAKKFQRQTANLQDCYRLYQAVNHLPTVV Q76FQ4_CHICK Q76FQ4_CHICK RLNLVEAFVVDTELRQGLQEDLLRRFPDLNRLAKKFQRQAATLQDCYRMYQAINQLPNVV MATCH **:***::. * ** : ***********:*::**::**::.*:****:**.: ::* :: CONSENSUS RLNLVEAFVED?ELRQ?LQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQ??NQLP?V?

Q4T7V9_TETNG Q4T7V9_TETNG TALDRHAGSHRTLLEAVFAAPLRDLQADFVKYQEMIETTLDMHQVTALWAPCPHAHGRRA Q803R6_DANRE Q803R6_DANRE LALERYSGKHQVLLHAAFISPLNDLISDFSKFQEMIETTLDMNQV--------------- Q90XA7_DANRE Q90XA7_DANRE LALERYSGKHQVLLHAAFISPLNDLISDFSKFQEMIETTLDMNQV--------------- MSH2_BOVIN MSH2_BOVIN QALEKYEGKHQALFLAVFVTPLIDLRSDFSKFQEMIETTLDMDQV--------------- Q5SBJ2_CANFA Q5SBJ2_CANFA RALEKYEGKHQGLLLAVFVTPLIDLRSDFSKFQEMIETTLDMDQV--------------- MSH2_CERAE MSH2_CERAE QALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQV--------------- Q4R336_MACFA Q4R336_MACFA QALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQV--------------- B4DN49_HUMAN B4DN49_HUMAN QALEKHEGKHQKLLLAVFATPLTDLRSDFSKFQEMIETTLDMDQV--------------- B4DSB9_HUMAN B4DSB9_HUMAN QALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQV--------------- B4DL39_HUMAN B4DL39_HUMAN QALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQV--------------- B4E2Z2_HUMAN B4E2Z2_HUMAN QALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQV--------------- Q53GS1_HUMAN Q53GS1_HUMAN QALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEVIETTLDMDQV--------------- MSH2_HUMAN MSH2_HUMAN QALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQV--------------- Q53FK0_HUMAN Q53FK0_HUMAN QALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQV--------------- Q5R4H9_PONAB Q5R4H9_PONAB QALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQV--------------- Q53RU4_HUMAN Q53RU4_HUMAN QALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQV--------------- MSH2_MOUSE MSH2_MOUSE QALEKYEGRHQALLLAVFVTPLIDLRSDFSKFQEMIETTLDMDQV--------------- Q3TZI5_MOUSE Q3TZI5_MOUSE QALEKYEGRHQALLLAVFVTPLIDLRSDFSKFQEMIETTLDMDQV--------------- Q80V79_MOUSE Q80V79_MOUSE QALEKYEGRHQALLLAVFVTPLIDLRSDFSKFQEMIETTLDMDQV--------------- B2DD05_MESAU B2DD05_MESAU QALKKYQGRHQALLLAVFVTPLIDLRSDFSKFQEMIETTLDMDQV--------------- B1WBQ7_RAT B1WBQ7_RAT QALEKYQGRHQALLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQV--------------- MSH2_RAT MSH2_RAT QALEKYQGRHQALLLAVFVTPLTDLRSDFSKFQEKIETTLDMDQV--------------- Q5HZF7_XENLA Q5HZF7_XENLA QAIEKYEGTHQMLLLAVFATPLSDLSSDFSKFQEMIETTLDMDQV--------------- Q76FQ4_CHICK Q76FQ4_CHICK QALEKHEGAHQMLLLAGFITPLNDIHSDFSKFLEMIETTVDMDKV--------------- MATCH *:.:: * *: *: * * :** *: :** *: * ****:**.:* CONSENSUS QALEK??G?HQ?LLLAVF?TPL?DL?SDFSKFQEMIETTLDMDQV???????????????

Q4T7V9_TETNG Q4T7V9_TETNG VTVARCLQIEHHEFLIKASFDPVLSELRGKMDQLEKSMQAVLKSAARDLGLEAGKTVKLE Q803R6_DANRE Q803R6_DANRE ---------EHHEFLVKPSFDPTLSDLRENMDRLEKAMQAALSSAARELGLEAAKTVKLE Q90XA7_DANRE Q90XA7_DANRE ---------EHHEFLVKPSFDPTLSDLRENMDRLEKAMQAALSSAARGLGLEATKTVKLE MSH2_BOVIN MSH2_BOVIN ---------ENHEFLVKPSFDPNLSELREIMDDLEKKMQSTLVSAARDLGLDPGKQIKLD Q5SBJ2_CANFA Q5SBJ2_CANFA ---------ENHEFLVKPSFDPNLSELREIMDDLEKKMQSTLISAARDLGLDPGKQIKLD MSH2_CERAE MSH2_CERAE ---------ENHEFLVKPSFDPNLSELREIMNDLEKKMQSTLISAARDLGLDPGKQIKLD Q4R336_MACFA Q4R336_MACFA ---------ENHEFLVKPSFDPNLSELREIMNDLEKKMQSTLISAARDLGLDPGKQIKLD B4DN49_HUMAN B4DN49_HUMAN ---------ENHEFLVKPSFDPNLSELREIMNDLEKKMQSTLISAARDLGLDPGKQIKLD B4DSB9_HUMAN B4DSB9_HUMAN ---------ENHEFLVKPSFDPNLSELREIMNDLEKKMQSTLISAARDLGLDPGKQIKLD B4DL39_HUMAN B4DL39_HUMAN ---------ENHEFLVKPSFDPNLSELREIMNDLEKKMQSTLISAARDLGLDPGKQIKLD B4E2Z2_HUMAN B4E2Z2_HUMAN ---------ENHEFLVKPSFDPNLSELREIMNDLEKKMQSTLISAARDLGLDPGKQIKLD Q53GS1_HUMAN Q53GS1_HUMAN ---------ENHEFLVKPSFDPNLSELREIMNDLEKKMQSTLISAARDLGLDPGKQIKLD MSH2_HUMAN MSH2_HUMAN ---------ENHEFLVKPSFDPNLSELREIMNDLEKKMQSTLISAARDLGLDPGKQIKLD Q53FK0_HUMAN Q53FK0_HUMAN ---------ENHEFLVKPSFDPNLSELREIMNDLEKKMQSTLISAARDLGLDPGKQIKLD Q5R4H9_PONAB Q5R4H9_PONAB ---------ENHEFLVKPSFDPNLSELREIMNDLEKKMQSTLISAARDLGLDPGKQIKLD Q53RU4_HUMAN Q53RU4_HUMAN ---------ENHEFLVKPSFDPNLSELREIMNDLEKKMQSTLISAARDLGLDPGKQIKLD MSH2_MOUSE MSH2_MOUSE ---------ENHEFLVKPSFDPNLSELREVMDGLEKKMQSTLINAARGLGLDPGKQIKLD Q3TZI5_MOUSE Q3TZI5_MOUSE ---------ENHEFLVKPSFDPNLSELREVMDGLEKKMQSTLINAARGLGLDPGKQIKLD Q80V79_MOUSE Q80V79_MOUSE ---------ENHEFLVKPSFDPNLSELREVMDGLEKKMQSTLINAARGLGLDPGKQIKLD B2DD05_MESAU B2DD05_MESAU ---------ENHEFLIKPSFDPNLSELREVMDGLEKKLQSTLISAARGLGLDPGKQMKLD B1WBQ7_RAT B1WBQ7_RAT ---------ENHEFLVKPSFDPNLSELREVMDGLEKKMQSTLISAARGLGLDPGKQIKLD MSH2_RAT MSH2_RAT ---------ENHEFLVKPSFDPNLSELREVMDGLEKKMQSTLISAARGLGLDPGKQIKLD Q5HZF7_XENLA Q5HZF7_XENLA ---------ENHEFLVKASFDPNLTELREKMDELEKNMQGALGGAARELGLDAGKSIKLE Q76FQ4_CHICK Q76FQ4_CHICK ---------ENHEFLVKASFDPNLTELREKMNELEESMQTLLKSAAKELGLEAGKSIKLE MATCH *:****:*.**** *::** *: **: :* * .**: ***:. * :**: CONSENSUS ?????????ENHEFLVKPSFDPNLSELRE?M??LEK?MQ??L?SAAR?LGLD?GK?IKL?

Q4T7V9_TETNG Q4T7V9_TETNG SNAALGFYLRVTCKEEKALRNNRKFTMLDVQKNGVRFTSRSVPLSCDPGGCGQLTVCSGS Q803R6_DANRE Q803R6_DANRE SNAQIGYFFRVTCKEEKSLRNNKKFTTLDVQKNGVRFTN--------------------- Q90XA7_DANRE Q90XA7_DANRE SNAQIGYFFRVTCKEEKSLRNNKKFTTLDVQKNGVRFTN--------------------- MSH2_BOVIN MSH2_BOVIN SSTQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTN--------------------- Q5SBJ2_CANFA Q5SBJ2_CANFA SSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTN--------------------- MSH2_CERAE MSH2_CERAE SSTQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTN--------------------- Q4R336_MACFA Q4R336_MACFA SSTQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTN--------------------- B4DN49_HUMAN B4DN49_HUMAN SSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTN--------------------- B4DSB9_HUMAN B4DSB9_HUMAN SSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTN--------------------- B4DL39_HUMAN B4DL39_HUMAN SSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTN--------------------- B4E2Z2_HUMAN B4E2Z2_HUMAN SSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTN--------------------- Q53GS1_HUMAN Q53GS1_HUMAN SSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTN--------------------- MSH2_HUMAN MSH2_HUMAN SSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTN--------------------- Q53FK0_HUMAN Q53FK0_HUMAN SSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTN--------------------- Q5R4H9_PONAB Q5R4H9_PONAB SSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTN--------------------- Q53RU4_HUMAN Q53RU4_HUMAN SSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTN--------------------- MSH2_MOUSE MSH2_MOUSE SSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTN--------------------- Q3TZI5_MOUSE Q3TZI5_MOUSE SSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTN--------------------- Q80V79_MOUSE Q80V79_MOUSE SSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTN--------------------- B2DD05_MESAU B2DD05_MESAU SSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTN--------------------- B1WBQ7_RAT B1WBQ7_RAT SSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTN--------------------- MSH2_RAT MSH2_RAT SSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTN--------------------- Q5HZF7_XENLA Q5HZF7_XENLA SNSQIGHYFRVTCKEEKALRNNKKFTTIDIQKNGVRFTN--------------------- Q76FQ4_CHICK Q76FQ4_CHICK SNSQFGHHFRITCKEEKVLRNNTKFKITDTQKNGVKFTN--------------------- MATCH *.: :*..:*:****** **** :*. * *****:**. CONSENSUS S??QFGYYFRVTCKEEKVLRNNK?F?T?DIQKNGVKFTN?????????????????????

Q4T7V9_TETNG Q4T7V9_TETNG RRCSKLSSVNEEYSRSRGEYEEAQDAIVKEIINIASGEPRRRRRPRPRLRGSAADAERRH Q803R6_DANRE Q803R6_DANRE ---SKLSSLNEEYTKSREEYEEAQNAIVKEIISIAAG----YVDPVQTLNEVIAQLD--- Q90XA7_DANRE Q90XA7_DANRE ---SKLSSLNEEYTKSREEYEEAQNAIVKEIISIAAG----YVDPVQTLNEVIAQLD--- MSH2_BOVIN MSH2_BOVIN ---SKLTSLNEEYTKNKTEYEEAQNAIVKEIVNISSG----YVEPMQTLNDVLAQLD--- Q5SBJ2_CANFA Q5SBJ2_CANFA ---SKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISSG----YVEPMQTLNDVLAQLD--- MSH2_CERAE MSH2_CERAE ---SKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISSG----YVEPMQTLNDVLAQLD--- Q4R336_MACFA Q4R336_MACFA ---SKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISSG----YVEPMQTLNDVLAQLD--- B4DN49_HUMAN B4DN49_HUMAN ---SKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISSG----YVEPMQTLNDVLAQLD--- B4DSB9_HUMAN B4DSB9_HUMAN ---SKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISSG----YVEPMQTLNDVLAQLD--- B4DL39_HUMAN B4DL39_HUMAN ---SKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISSG----YVEPMQTLNDVLAQLD--- B4E2Z2_HUMAN B4E2Z2_HUMAN ---SKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISSG----YVEPMQTLNDVLAQLD--- Q53GS1_HUMAN Q53GS1_HUMAN ---SKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISSG----YVEPMQTLNDVLAQLD--- MSH2_HUMAN MSH2_HUMAN ---SKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISSG----YVEPMQTLNDVLAQLD--- Q53FK0_HUMAN Q53FK0_HUMAN ---SKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISSG----YVEPMQTLNDVLAQLD--- Q5R4H9_PONAB Q5R4H9_PONAB ---SKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISSG----YVEPMQTLNDVLAQLD--- Q53RU4_HUMAN Q53RU4_HUMAN ---SKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISS------------------------ MSH2_MOUSE MSH2_MOUSE ---SELSSLNEEYTKNKGEYEEAQDAIVKEIVNISSG----YVEPMQTLNDVLAHLD--- Q3TZI5_MOUSE Q3TZI5_MOUSE ---SELSSLNEEYTKNKGEYEEAQDAIVKEIVNISSG----YVEPMQTLNDVLAHLD--- Q80V79_MOUSE Q80V79_MOUSE ---SELSSLNEEYTKNKGEYEEAQDAIVKEIVNISSG----YVEPMQTLNDVLAHLD--- B2DD05_MESAU B2DD05_MESAU ---SELSALNEEYTKNKGEYEEAQDAIVKEIVNISSG----YVEPMQTLNDVLAQLD--- B1WBQ7_RAT B1WBQ7_RAT ---SELSSLNEEYTKNKGEYEEAQDAIVKEIVNISSG----YVEPMQTLNDVLAHLD--- MSH2_RAT MSH2_RAT ---SELSSLNEEYTKNKGEYEEAQDAIVKEIVNISSG----YVEPMQTVNDVLAHLD--- Q5HZF7_XENLA Q5HZF7_XENLA ---SKLSSLSEEYMRNREEYEEAQNAIVKEIITISAG----YVDPIQTLNDVIAQLD--- Q76FQ4_CHICK Q76FQ4_CHICK ---SKLSAINEEYIKNREEYEEAQDAIVKEIINIASG----YAEPIQTMNDVIAQLD--- MATCH *:*:::.*** :.: ******:******:.*:: CONSENSUS ???S?L?SLNEEYTKN??EYEEAQDAIVKEI?NISSG????YV?P?QTLNDV?A?LD???

Q4T7V9_TETNG Q4T7V9_TETNG GGWYAVVSLAVASVSAPVPYVRPRLLAKDQSPRRMQLLQGRHPCMEADADTGLIPNEITF Q803R6_DANRE Q803R6_DANRE ----AVLSFAVVSHAAPVPFIRPKILEKGSG--RLVLKAARHPCVEAQDEVAFIPNDVTF Q90XA7_DANRE Q90XA7_DANRE ----AVVSFAVVSHTAPVPFIRPKILEKGSG--RLVLKAARHPCVEAQDEVAFIPNDVTF MSH2_BOVIN MSH2_BOVIN ----AVVSFAHVSDAAPVPYVRPVILEKGRG--RITLKASRHACVEVQDEVAFIPNDVHF Q5SBJ2_CANFA Q5SBJ2_CANFA ----AVVSFAHVSNGAPVPYVRPAIL---------------------------------- MSH2_CERAE MSH2_CERAE ----AVVSFAHVSNGAPVPYVRPAILEKGQG--RIILKASRHACVEVQDEITFIPNDIYF Q4R336_MACFA Q4R336_MACFA ----AVVSFAHVSNGAPVPYVRPAILEKGQG--RIILKASRHACVEVQDEITFIPNDIYF B4DN49_HUMAN B4DN49_HUMAN ----AVVSFAHVSNGAPVPYVRPAILEKGQG--RIILKASRHACVEVQDEIAFIPNDVYF B4DSB9_HUMAN B4DSB9_HUMAN ----AVVSFAHVSNGAPVPYVRPAILEKGQG--RIILKASRHACVEVQDEIAFIPNDVYF B4DL39_HUMAN B4DL39_HUMAN ----AVVSFAHVSNGAPVPYVRPAILEKGQG--RIILKASRHACVEVQDEIAFIPNDVYF B4E2Z2_HUMAN B4E2Z2_HUMAN ----AVVSFAHVSNGAPVPYVRPAILEKGQG--RIILKASRHACVEVQDEIAFIPNDVYF Q53GS1_HUMAN Q53GS1_HUMAN ----AVVSFAHVSNGAPVPYVRPAILEKGQG--RIILKASRHACVEVQDEIAFIPNDVYF MSH2_HUMAN MSH2_HUMAN ----AVVSFAHVSNGAPVPYVRPAILEKGQG--RIILKASRHACVEVQDEIAFIPNDVYF Q53FK0_HUMAN Q53FK0_HUMAN ----AVVSFAHVSNGAPVPYVRPAILGKGQG--RIILKASRHACVEVQDEIAFIPNDVYF Q5R4H9_PONAB Q5R4H9_PONAB ----AVVSFAHVSNGAPVPYVRPAILEKGQG--RIILKASRHACVEVQDEIAFIPNDVYF Q53RU4_HUMAN Q53RU4_HUMAN ------------------------------------------------------------ MSH2_MOUSE MSH2_MOUSE ----AIVSFAHVSNAAPVPYVRPVILEKGKG--RIILKASRHACVEVQDEVAFIPNDVHF Q3TZI5_MOUSE Q3TZI5_MOUSE ----AIVSFAHVSNAAPVPYVRPVILEKGKG--RIILKASRHACVEVQDEVAFIPNDVHF Q80V79_MOUSE Q80V79_MOUSE ----AIVSFAHVSNAAPVPYVRPVILEKGKG--RIILKASRHACVEVQDEVAFIPNDVHF B2DD05_MESAU B2DD05_MESAU ----AVVSFAHVSNAAPVPYVRPVILEKGKG--RIVLKASRHACVEVQDEVAFIPNDVHF B1WBQ7_RAT B1WBQ7_RAT ----AVVSFAHVSNAAPVPYVRPVILEKGKG--RIILKASRHACVEVQDDVAFIPNDVHF MSH2_RAT MSH2_RAT ----AVVSFAHVSNAAPVPYVRPVILEKGKG--RIIVKASRHACVEVQHDVAFIPNDVHF Q5HZF7_XENLA Q5HZF7_XENLA ----AVVSFAHVSNSAPVPYVRPVILEKGQG--RIVLHSARHPCIEMQDDVAFIPNDITF Q76FQ4_CHICK Q76FQ4_CHICK ----AIVSFAHVSNGAPVPYVRPVVLEKGQG--RIVLKGARHPCIEVQDEVAFIPNDVTF MATCH CONSENSUS ????A?VSFAHVS??APVPYVRP?ILEKG?G??R??LK??RH?C?E?QD???FIPND??F

Q4T7V9_TETNG Q4T7V9_TETNG VQGEKSFYIITG-------------GVIALMAQIGCFVPCEKAELSVIDSILARVGAGDS Q803R6_DANRE Q803R6_DANRE IRGEKMFHIITGPSMGGKSTYIRQVGVIVLMAQIGCFVPCDEAELSVVDCVLARVGAGDS Q90XA7_DANRE Q90XA7_DANRE ISGEKMFHIITGPNMGGKSTYIRQVGVIVLMAQIGCFVPCDEAELSVVDCVLARVGAGDS MSH2_BOVIN MSH2_BOVIN EKDKQMFHIITGPNMGGKSTYIRQTGVVVLMAQIGCFVPCEWAEVSIVDCILARVGAGDS Q5SBJ2_CANFA Q5SBJ2_CANFA ------------------------------------------------------------ MSH2_CERAE MSH2_CERAE EKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDS Q4R336_MACFA Q4R336_MACFA EKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDS B4DN49_HUMAN B4DN49_HUMAN EKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDS B4DSB9_HUMAN B4DSB9_HUMAN EKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDS B4DL39_HUMAN B4DL39_HUMAN EKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDS B4E2Z2_HUMAN B4E2Z2_HUMAN EKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDS Q53GS1_HUMAN Q53GS1_HUMAN EKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDS MSH2_HUMAN MSH2_HUMAN EKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDS Q53FK0_HUMAN Q53FK0_HUMAN EKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDS Q5R4H9_PONAB Q5R4H9_PONAB EKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDS Q53RU4_HUMAN Q53RU4_HUMAN ------------------------------------------------------------ MSH2_MOUSE MSH2_MOUSE EKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDS Q3TZI5_MOUSE Q3TZI5_MOUSE EKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDS Q80V79_MOUSE Q80V79_MOUSE EKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDS B2DD05_MESAU B2DD05_MESAU EKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSILDCILARVGAGDS B1WBQ7_RAT B1WBQ7_RAT EKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDS MSH2_RAT MSH2_RAT EKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDS Q5HZF7_XENLA Q5HZF7_XENLA EKEKQMFQIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCDSAQVSIVDCILARVGAGDS Q76FQ4_CHICK Q76FQ4_CHICK EKGKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCDSAEITIVDCILARVGAGDS MATCH CONSENSUS ?????MFHIITGPNMGGKSTYIRQ?GVIVLMAQIGCFVPC??AE?S?VDCILARVGAGDS

Q4T7V9_TETNG Q4T7V9_TETNG Q-------------------SASAASLIIIDELGRGTSTYDGFGLAWAISQHVASRIGCF Q803R6_DANRE Q803R6_DANRE QIKGVSTFMAEMLETAAILRSATEDSLITIDELGRGTSTYDGFGLAWAISEYIATRLKSF Q90XA7_DANRE Q90XA7_DANRE QIKGVSTFMAEMLETAAILRSASEDSLIIIDELGRGTSTYDGFGLAWAISEYIATRLKSF MSH2_BOVIN MSH2_BOVIN QLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAF Q5SBJ2_CANFA Q5SBJ2_CANFA ------------------------------------------------------------ MSH2_CERAE MSH2_CERAE QLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAF Q4R336_MACFA Q4R336_MACFA QLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAF B4DN49_HUMAN B4DN49_HUMAN QLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAF B4DSB9_HUMAN B4DSB9_HUMAN QLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAF B4DL39_HUMAN B4DL39_HUMAN QLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAF B4E2Z2_HUMAN B4E2Z2_HUMAN QLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAF Q53GS1_HUMAN Q53GS1_HUMAN QLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAF MSH2_HUMAN MSH2_HUMAN QLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAF Q53FK0_HUMAN Q53FK0_HUMAN QLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAF Q5R4H9_PONAB Q5R4H9_PONAB QLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAF Q53RU4_HUMAN Q53RU4_HUMAN ------------------------------------------------------------ MSH2_MOUSE MSH2_MOUSE QLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISDYIATKIGAF Q3TZI5_MOUSE Q3TZI5_MOUSE QLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISDYIATKIGAF Q80V79_MOUSE Q80V79_MOUSE QLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISDYIATKIGAF B2DD05_MESAU B2DD05_MESAU QLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAF B1WBQ7_RAT B1WBQ7_RAT QLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAF MSH2_RAT MSH2_RAT QLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATNIGAF Q5HZF7_XENLA Q5HZF7_XENLA QLKGVSTFMAEMLETASILRSATENSLIIIDELGRGTSTYDGFGLAWAISEYISTKIKAF Q76FQ4_CHICK Q76FQ4_CHICK QLKGVSTFMAEMLETASILRTASENSLIIIDELGRGTSTYDGFGLAWAISEYIASKICAF MATCH CONSENSUS Q?KGVSTFMAEMLETA?ILRSA???SLIIIDELGRGTSTYDGFGLAWAIS?YIAT?I??F

Q4T7V9_TETNG Q4T7V9_TETNG CLFATHFHELTALAAQQPAVHNLHVTALTSQDALTMLYRVRPGVCDQSFGIHVAEMAGFP Q803R6_DANRE Q803R6_DANRE CLFATHFHELTALAQQVPTVRNLHVTALTTDSTLTMLYKVKKGVCDQSFGIHVAELASFP Q90XA7_DANRE Q90XA7_DANRE CLFATHFHELTALAQQVPTVRNLHVTALTTDSTLTMLYKVKKGVCDQSFGIHVAELASFP MSH2_BOVIN MSH2_BOVIN CMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFP Q5SBJ2_CANFA Q5SBJ2_CANFA ------------------------------------------------------------ MSH2_CERAE MSH2_CERAE CMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFP Q4R336_MACFA Q4R336_MACFA CMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFP B4DN49_HUMAN B4DN49_HUMAN CMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFP B4DSB9_HUMAN B4DSB9_HUMAN CMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFP B4DL39_HUMAN B4DL39_HUMAN CMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFP B4E2Z2_HUMAN B4E2Z2_HUMAN CMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFP Q53GS1_HUMAN Q53GS1_HUMAN CMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFP MSH2_HUMAN MSH2_HUMAN CMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFP Q53FK0_HUMAN Q53FK0_HUMAN CMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFP Q5R4H9_PONAB Q5R4H9_PONAB CMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFP Q53RU4_HUMAN Q53RU4_HUMAN ------------------------------------------------------------ MSH2_MOUSE MSH2_MOUSE CMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFP Q3TZI5_MOUSE Q3TZI5_MOUSE CMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFP Q80V79_MOUSE Q80V79_MOUSE CMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFP B2DD05_MESAU B2DD05_MESAU CMFAT------------------------------------------------------- B1WBQ7_RAT B1WBQ7_RAT CMFATHFHELTALASQIPTVNNLHVTALTTEETLTMLYQVKTGVCDQSFGIHVAELANFP MSH2_RAT MSH2_RAT CMFATHFHELTALASQIPTVNNLHVTALTTEETLTMLYQVKTGVCDQSFGIHVAELANFP Q5HZF7_XENLA Q5HZF7_XENLA CMFATHFHELTALADQVPTVNNLHVTALTTEDTLTMLYRIKKGVCDQSFGIHVAELANFP Q76FQ4_CHICK Q76FQ4_CHICK CMFATHFHELTALADQVPTVNNLHVTALTSDDTLTMLYRVKAGVCDQSFGIHVAELAAFP MATCH CONSENSUS C?FATHFHELTALA?Q?PTV?NLHVTALT???TLTMLY?VK?GVCDQSFGIHVAELA?FP

Q4T7V9_TETNG Q4T7V9_TETNG PAVVAMAKEKAEELEEFQEPAGETEQED--GPQAKRRRRDKQLGEKLIQDFLDQARALPV Q803R6_DANRE Q803R6_DANRE KHVIANAREKALELEEFQD-ISSVG--EEAGPKAKKRCMEKQEGERIIEAFLAKVKSMPV Q90XA7_DANRE Q90XA7_DANRE KHVIANAREKALELEEFQD-ISSVG--EEAGPKAKKRCMEKQEGEKIIEAFLAKVKPMPV MSH2_BOVIN MSH2_BOVIN RHVIECAKQKALELEEFQN-IGKPQECDEMEPAAKRCYLEREQGEKIIQEFLSKVKQVPF Q5SBJ2_CANFA Q5SBJ2_CANFA ------------------------------------------------------------ MSH2_CERAE MSH2_CERAE KHVIECAKQKALELEEFQY-IGESQGYD-MEPAAKKCYLEREQGEKIIQEFLSKVKQMPF Q4R336_MACFA Q4R336_MACFA KHVIECAKQKALELEEFQY-IGESQGYD-MEPAAKKCYLEREQGEKIIQEFLSKVKQMPF B4DN49_HUMAN B4DN49_HUMAN KHVIECAKQKALELEEFQY-IGESQGYDIMEPAAKKCYLEREQGEKIIQEFLSKVKQMPF B4DSB9_HUMAN B4DSB9_HUMAN KHVIECAKQKALELEEFQY-IGESQGYDIMEPAAKKCYLEREQGEKIIQEFLSKVKQMPF B4DL39_HUMAN B4DL39_HUMAN KHVIECAKQKALELEEFQY-IGESQGYDIMEPAAKKCYLEREQGEKIIQEFLSKVKQMPF B4E2Z2_HUMAN B4E2Z2_HUMAN KHVIECAKQKALELEEFQY-IGESQGYDIMEPAAKKCYLEREQGEKIIQEFLSKVKQMPF Q53GS1_HUMAN Q53GS1_HUMAN KHVIECAKQKALELEEFQY-IGESQGYDIMEPAAKKCYLERE------------------ MSH2_HUMAN MSH2_HUMAN KHVIECAKQKALELEEFQY-IGESQGYDIMEPAAKKCYLEREQGEKIIQEFLSKVKQMPF Q53FK0_HUMAN Q53FK0_HUMAN KHVIECAKQKALELEEFQY-IGESQGYDIMEPAAKKCYLERE------------------ Q5R4H9_PONAB Q5R4H9_PONAB KHVIECAKQKALELEEFQY-IGESQGYDIMEPAAKKCYLERE-----VCQFVFIV----- Q53RU4_HUMAN Q53RU4_HUMAN ------------------------------------------------------------ MSH2_MOUSE MSH2_MOUSE RHVIACAKQKALELEEFQN-IGTSLGCDEAEPAAKRRCLEREQGEKIILEFLSKVKQVPF Q3TZI5_MOUSE Q3TZI5_MOUSE RHVIACAKQKALELEEFQN-IGTSLGCDEAEPAAKRRCLEREQGEKIILEFLSKVKQVPF Q80V79_MOUSE Q80V79_MOUSE RHVIACAKQKALELEEFQN-IGTSLGCDEAEPAAKRRCLEREQGEKIILEFLSKFKQVPF B2DD05_MESAU B2DD05_MESAU ------------------------------------------------------------ B1WBQ7_RAT B1WBQ7_RAT RHVIECAKQKALELEEFQS-IGTSQGHDETQPAAKRRCLEREQGEKIILEFLSKVKQVPF MSH2_RAT MSH2_RAT RHVIECAKQKALELEEFQS-IGTSQGHDETQPAAKRRCLEREQGEKIILEFLSKVKQVPF Q5HZF7_XENLA Q5HZF7_XENLA KHVIETAKEKALELEEFQY-VGNPDDCDD-EPARKRRCEEKEEGEKIIQDFLSRVKALPL Q76FQ4_CHICK Q76FQ4_CHICK KHVIESAREKALELEEFQD-IGRPKESE-GEPAAKRCYREREEGEKIIQDFLSQVKALPL MATCH CONSENSUS ?HVI??A??KALELEEFQ?????????????P?AK????E????????????????????

Q4T7V9_TETNG Q4T7V9_TETNG STMSDDEVKAELRRLKQELVAKGNEYISDILAR--------- Q803R6_DANRE Q803R6_DANRE DGMSDKAVKEELRKLKAEVISQNNSFVNEIVSRSGKVKLSSA Q90XA7_DANRE Q90XA7_DANRE DGMSDKAVKEELRKLKAEVISQNNSFVNEIVSRSGKVKLSSA MSH2_BOVIN MSH2_BOVIN TEMSEESITRKLKQLKAEVIAKNNSFVNEIISR---IKVTA- Q5SBJ2_CANFA Q5SBJ2_CANFA ------------------------------------------ MSH2_CERAE MSH2_CERAE TEMSEENITIKLKQLKAEVIAKNNSFVNEIISR---IKVTT- Q4R336_MACFA Q4R336_MACFA TEMSEENITIKLKQLKAEVIAKNNSFVNEIISR---IKVTT- B4DN49_HUMAN B4DN49_HUMAN TEMSEENITIKLKQLKAEVIAKNNSFVNEIISR---IKVTT- B4DSB9_HUMAN B4DSB9_HUMAN TEMSEENITIKLKQLKAEVIAKNNSFVNEIISR---IKVTT- B4DL39_HUMAN B4DL39_HUMAN TEMSEENITIKLKQLKAEVIAKNNSFVNEIISR---IKVTT- B4E2Z2_HUMAN B4E2Z2_HUMAN TEMSEENITIKLKQLKAEVIAKNNSFVNEIISR---IKVTT- Q53GS1_HUMAN Q53GS1_HUMAN ------------------------------------------ MSH2_HUMAN MSH2_HUMAN TEMSEENITIKLKQLKAEVIAKNNSFVNEIISR---IKVTT- Q53FK0_HUMAN Q53FK0_HUMAN ------------------------------------------ Q5R4H9_PONAB Q5R4H9_PONAB ------------------------------------------ Q53RU4_HUMAN Q53RU4_HUMAN ------------------------------------------ MSH2_MOUSE MSH2_MOUSE TAMSEESISAKLKQLKAEVVAKNNSFVNEIISR---IKAPAP Q3TZI5_MOUSE Q3TZI5_MOUSE TAMSEESISAKLKQLKAEVVAKNNSFVNEIISR---IKAPAP Q80V79_MOUSE Q80V79_MOUSE TAMSEESISAKLKQLKAEVVAKNNSFVNEIISR---IKAPAP B2DD05_MESAU B2DD05_MESAU ------------------------------------------ B1WBQ7_RAT B1WBQ7_RAT TDLSEESVSVKLKQLKAEVLAKNNSFVNEIISR---VKAP-- MSH2_RAT MSH2_RAT TDLSEESVSVKLKQLKAEVLAKNNSFVNEIISR---VKAP-- Q5HZF7_XENLA Q5HZF7_XENLA TEMSEEEIKIKLKQFRADVLAKNNRFVSEVISR---TKTGL- Q76FQ4_CHICK Q76FQ4_CHICK TDMSEEDIKTKLKQLRADVLAKNNGFVNEIISR---TKVTP- MATCH CONSENSUS ??????????????????????????????????????????


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