Alignment of the gene Family HBG008238 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
PPE2_HUMAN PPE2_HUMAN GSGTSTQHHFAFQNAERAFKAAALIQRWYRRYVARLEMRRRCTWSIFQSIEYAGQQDQVK PPE2_MOUSE PPE2_MOUSE GSSSSTQHHFAFQNAEKAFKAAALIQRWYRRYMARLEMRRRCTWNIFQSIEYAGQQDQVK Q4RU11_TETNG Q4RU11_TETNG -----------------ALRAAVLIQRWYRQYVARSEMRRRCTWHIFQSIEYSGEQAQIK Q4SQB1_TETNG Q4SQB1_TETNG ---------FHTSSAIAAIRAALLIQRWYRQYVARLEMRRRYTWNIFQSIEYAGEQDQIK A8K870_HUMAN A8K870_HUMAN GCSSS---STKTRRSDTSLRAALIIQNWYRGYKARLKARQHYALTIFQSIEYADEQGQMQ B7Z6R7_HUMAN B7Z6R7_HUMAN ------------------------------------------------------------ B7Z353_HUMAN B7Z353_HUMAN ----------------------------------------------------------MQ B0AZL8_HUMAN B0AZL8_HUMAN GCSSS---STKTRRSDTSLRAALIIQNWYRGYKARLKARQHYALTIFQSIEYADEQGQMQ PPE1_HUMAN PPE1_HUMAN GCSSS---STKTRRSDTSLRAALIIQNWYRGYKARLKARQHYALTIFQSIEYADEQGQMQ Q4R441_MACFA Q4R441_MACFA GCSSS---STKTRKSETSLKAALIIQNWYRGYKARLKARQHYALTIFQSIEYADEQGQMQ Q4R4Y0_MACFA Q4R4Y0_MACFA GCSSS---STKTRKSETSLKAALIIQNWYRGYKARLKARQHYALTIFQSIEYADEQGQMQ PPE1_RAT PPE1_RAT GCGSS---SKKGKKSEKVVRAALIIQNWYRRYRARLSARQHYALAIFQSIEYADEQGQMQ PPE1_MOUSE PPE1_MOUSE GCGTS---SKKGNKSKKVIKAALVIQNWYRRYRARLRVRQHYALAIFQSIEYSDEQGQMQ Q3UQZ5_MOUSE Q3UQZ5_MOUSE ------------------------------------------------------------ B0JZB7_DANRE B0JZB7_DANRE GCGTSIAIENQTRPSETAIKAAILIQRWYRRYVAHLEMRRRYTWNIFQSIEYAGEQDQLQ Q4SHR7_TETNG Q4SHR7_TETNG -----------------AIKAAVLIQRWFRRYMAHLEMRRRYTWNIFQSIEYASEQDQLQ MATCH CONSENSUS ????????????????????AA??IQ?W?R?Y?A????R??????IFQSIEY???Q?Q??

PPE2_HUMAN PPE2_HUMAN LHDFFSYLMDHFIPSSHNDRDFLTRIF-TEDRFAQDSEMKKCSDYESIEVPDSYTGPRLS PPE2_MOUSE PPE2_MOUSE LHEFFSYLVDHFTPSSHHERDFLNRMF-TEERFAQDVETEEGGDFESIEVPDSYTGPRLS Q4RU11_TETNG Q4RU11_TETNG LSNFLNYLMDNFTPSS-NERNLISHIFRENEVCRDAEW-ERYFCYKNIEVPEIYSGPHLT Q4SQB1_TETNG Q4SQB1_TETNG LYDFFASLMEHFTPAS-SERNLISHIFRKNEVCCEADW-ERYFSYSSVEVPDSYSGPRPT A8K870_HUMAN A8K870_HUMAN LSTFFSFMLENYTHIHKEELELRNQSL-ES---EQDMR-DRWDYVDSIDVPDSYNGPRLQ B7Z6R7_HUMAN B7Z6R7_HUMAN -------MLENYTHIHKEELELRNQSL-ES---EQDMR-DRWDYVDSIDVPDSYNGPRLQ B7Z353_HUMAN B7Z353_HUMAN LSTFFSFMLENYTHIHKEELELRNQSL-ES---EQDMR-DRWDYVDSIDVPDSYNGPRLQ B0AZL8_HUMAN B0AZL8_HUMAN LSTFFSFMLENYTHIHKEELELRNQSL-ES---EQDMR-DRWDYVDSIDVPDSYNGPRLQ PPE1_HUMAN PPE1_HUMAN LSTFFSFMLENYTHIHKEELELRNQSL-ES---EQDMR-DRWDYVDSIDVPDSYNGPRLQ Q4R441_MACFA Q4R441_MACFA LSTFFSFMFENYAHVHKGELELRNQSL-ES---EQDLR-DRHDYVDLIDVPDSYNGPRLQ Q4R4Y0_MACFA Q4R4Y0_MACFA LSTFFSFMFENYAHVHKEELELRNQSL-ES---EQDLR-DRHDYVDLIDVPDSYNGPRLQ PPE1_RAT PPE1_RAT LSSFFSFMLENYTNTHKEDSALVSRLF-ENTRLESK---DREEYVGLIDVPDSYDGPRLQ PPE1_MOUSE PPE1_MOUSE LSSFFSFMLENYTKTNNEDSALVTRIF-DNTRRESQIK-DRDDFLGLIEVPDSYDGPRLQ Q3UQZ5_MOUSE Q3UQZ5_MOUSE -------MLENYTKTNNEDSALVTRIF-DNTRRESQIK-DRDDFLGLIEVPDSYDGPRLQ B0JZB7_DANRE B0JZB7_DANRE LSSFFTFMLDNFTQMNGNGPDLISHLL-DSVVDPLTEE-VRQLKYEQIMVPESYSGPRLS Q4SHR7_TETNG Q4SHR7_TETNG LSSFFSFMLNNITHLNGSGPDLISKLM-DS---ASDSWMENENCYNFVSVPETYTGPRLS MATCH :.:: : .: : . . : **: * **: CONSENSUS L??FF?????N?T????????L??????????????????R??????I?VPDSY?GPRL?

PPE2_HUMAN PPE2_HUMAN FPLLPDHATALVEAFRLKQQLHARYVLNLLYETKKHLVQLPNINRVSTCYSEEITVC--- PPE2_MOUSE PPE2_MOUSE FPLLPDHATALVEAFRLRQQLHARYVLNLLYETRKHLAQLPNINRVSTCYSEEVTVC--- Q4RU11_TETNG Q4RU11_TETNG FPLTVEQAVGLVEAFRNKKQLHSRYILQLLLETWKLLRMLPNINRISTCHSKEITICGEL Q4SQB1_TETNG Q4SQB1_TETNG FPLTLCGVLKLVEAFKHKQQLHARYVLQLLGETWRFLRILPNINQVSACQNREITIC--- A8K870_HUMAN A8K870_HUMAN FPLTCTDIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHIQTSPSKEVTIC--- B7Z6R7_HUMAN B7Z6R7_HUMAN FPLTCTDIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHIQTSPSKEVTIC--- B7Z353_HUMAN B7Z353_HUMAN FPLTCTDIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHIQTSPSKEVTIC--- B0AZL8_HUMAN B0AZL8_HUMAN FPLTCTDIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHIQTSPSKEVTIC--- PPE1_HUMAN PPE1_HUMAN FPLTCTDIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHIQTSPSKEVTIC--- Q4R441_MACFA Q4R441_MACFA FPLTCTDIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHVQTSPSKELTIC--- Q4R4Y0_MACFA Q4R4Y0_MACFA FPLTCTDIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHVQTSPSKELTIC--- PPE1_RAT PPE1_RAT FPLTFTDINLLLQAFKQQQTLHAHYVLEVLFEARKILKQMPNFTRIQTFPAKEITIC--- PPE1_MOUSE PPE1_MOUSE FPLTFTDIHILLQAFKQQQILHAHYVLEVLFEARKVLKQMPNFSHVKTFPAKEITIC--- Q3UQZ5_MOUSE Q3UQZ5_MOUSE FPLTFTDIHILLQAFKQQQILHAHYVLEVLFEARKVLKQMPNFSHVKTFPAKEITIC--- B0JZB7_DANRE B0JZB7_DANRE FPLSVTDTNALLSAFKEEQTLHGKYVLQLLYETKKFLKQMPNVIYLSTSYAKEITIC--- Q4SHR7_TETNG Q4SHR7_TETNG FPLSLPDMNALLSAFKERQTLHARYVLQLLYETRKLLKQMPNIVHLSTTYTKEITIC--- MATCH *** *:.**: .: **.:*:*::* *: : * :**. :.: .*:*:* CONSENSUS FPL???????L??AFK??Q?LHA?YVL??L?ET?K?L?Q?PN?????T???KE?TIC???

PPE2_HUMAN PPE2_HUMAN -------------------------------GDLHGQLDDLIFIFYK------------- PPE2_MOUSE PPE2_MOUSE -------------------------------GDLHGQLDDLIFIFYK------------- Q4RU11_TETNG Q4RU11_TETNG QEGFGNGGLCREIVGFTLPKTVLRTWVAAPIGDLHGQLEDLLLIFYKVRNPLPLFYMFSP Q4SQB1_TETNG Q4SQB1_TETNG -------------------------------GDLHGHLEDLLVIFYK-RELVP------- A8K870_HUMAN A8K870_HUMAN -------------------------------GDLHGKLDDLFLIFYK------------- B7Z6R7_HUMAN B7Z6R7_HUMAN -------------------------------GDLHGKLDDLFLIFYK------------- B7Z353_HUMAN B7Z353_HUMAN -------------------------------GDLHGKLDDLFLIFYK------------- B0AZL8_HUMAN B0AZL8_HUMAN -------------------------------GDLHGKLDDLFLIFYK------------- PPE1_HUMAN PPE1_HUMAN -------------------------------GDLHGKLDDLFLIFYK------------- Q4R441_MACFA Q4R441_MACFA -------------------------------GDLHGKLDDLFMIFYK------------- Q4R4Y0_MACFA Q4R4Y0_MACFA -------------------------------GDLHGKLDDLFMIFYK------------- PPE1_RAT PPE1_RAT -------------------------------GDLHGKLDDLMLIFYK------------- PPE1_MOUSE PPE1_MOUSE -------------------------------GDLHGKLDDLMLIFYK------------- Q3UQZ5_MOUSE Q3UQZ5_MOUSE -------------------------------GDLHGKLDDLMLIFYK------------- B0JZB7_DANRE B0JZB7_DANRE -------------------------------GDLHGRLDDLLLIFYK------------- Q4SHR7_TETNG Q4SHR7_TETNG -------------------------------GDLHGQLDDLLLIFYK------------- MATCH *****:*:**:.**** CONSENSUS ???????????????????????????????GDLHG?LDDL??IFYK?????????????

PPE2_HUMAN PPE2_HUMAN -----------------------------NGLPSPERSYVFNGDFVDRGKDSVEILMILF PPE2_MOUSE PPE2_MOUSE -----------------------------NGLPSPERAYVFNGDFVDRGKDSVEVLMVLF Q4RU11_TETNG Q4RU11_TETNG TVVFLHVTYEQTSNNNKKNPRVFNNCALQNGMPSLEKPYVFNGDFVDRGRDSIEILVILF Q4SQB1_TETNG Q4SQB1_TETNG ---------------------------AQNGFPSSEKPYVFNGDFVDRGKSSIEILLILF A8K870_HUMAN A8K870_HUMAN -----------------------------NGLPSERNPYVFNGDFVDRGKNSIEILMILC B7Z6R7_HUMAN B7Z6R7_HUMAN -----------------------------NGLPSERNPYVFNGDFVDRGKNSIEILMILC B7Z353_HUMAN B7Z353_HUMAN -----------------------------NGLPSERNPYVFNGDFVDRGKNSIEILMILC B0AZL8_HUMAN B0AZL8_HUMAN -----------------------------NGLPSERNPYVFNGDFVDRGKNSIEILMILC PPE1_HUMAN PPE1_HUMAN -----------------------------NGLPSERNPYVFNGDFVDRGKNSIEILMILC Q4R441_MACFA Q4R441_MACFA -----------------------------NGLPSESNPYVFNGDFVDRGKNSIEILIILC Q4R4Y0_MACFA Q4R4Y0_MACFA -----------------------------NGLPSESNPYVFNGDFVDRGKNSIEILIILC PPE1_RAT PPE1_RAT -----------------------------NGLPSEKNPYVFNGDFVDRGNNSMEILMILL PPE1_MOUSE PPE1_MOUSE -----------------------------NGLPSENNPYVFNGDFVDRGNNSMEILMILL Q3UQZ5_MOUSE Q3UQZ5_MOUSE -----------------------------NGLPSENNPYVFNGDFVDRGNNSMEILMILL B0JZB7_DANRE B0JZB7_DANRE -----------------------------NGLPSAENPYIFNGDFVDRGKKSTEIIIILF Q4SHR7_TETNG Q4SHR7_TETNG -----------------------------NGLPSAETPYVFNGDFVDRGKNSIEVVVLLF MATCH **:** .*:*********..* *::::* CONSENSUS ?????????????????????????????NGLPS???PYVFNGDFVDRG??S?EIL?IL?

PPE2_HUMAN PPE2_HUMAN AFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVHGKEILRTLQDVFCWLPLATLI PPE2_MOUSE PPE2_MOUSE AFMLVYPKEFHLNRGNHEDHLVNLRYGFTKEVMHKYKIHGKKILRTLQDVFCWLPLATLV Q4RU11_TETNG Q4RU11_TETNG AFLLVYPSDVYLNRGNHEDHIVNLRYGFTKEVLTKYKMHGKRILKLLQKIFSWLPLATVI Q4SQB1_TETNG Q4SQB1_TETNG GFLLVYPNDVHLNRGNHEDHIVNLRYGFTKEVWGKYRVHGKKILKLLQKIFSWLPLATLV A8K870_HUMAN A8K870_HUMAN VSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKLHGKRILQILEEFYAWLPIGTIV B7Z6R7_HUMAN B7Z6R7_HUMAN VSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKLHGKRILQILEEFYAWLPIGTIV B7Z353_HUMAN B7Z353_HUMAN VSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKLHGKRILQILEEFYAWLPIGTIV B0AZL8_HUMAN B0AZL8_HUMAN VSFLVYPNDLHLSRGNHEDFMMNLRYGFTKEILHKYKLHGKRILQILEEFYAWLPIGTIV PPE1_HUMAN PPE1_HUMAN VSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKLHGKRILQILEEFYAWLPIGTIV Q4R441_MACFA Q4R441_MACFA VSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKLHGKRILQILEELYAWLPIGTIV Q4R4Y0_MACFA Q4R4Y0_MACFA VSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKLHGKRILQILEELYAWLPIGTIV PPE1_RAT PPE1_RAT VSFLVYPTDLHLNRGNHEDFMMNLRYGFTKEILQKYKLHGKKILQVLEELYTWLPIGTII PPE1_MOUSE PPE1_MOUSE VCFLVYPSDLHLNRGNHEDFMMNLRYGFTKEILQKYKLHGRKILQVLEEVYTWLPIGTII Q3UQZ5_MOUSE Q3UQZ5_MOUSE VCFLVYPSDLHLNRGNHEDFMMNLRYGFTKEILQKYKLHGRKILQVLEEVYTWLPIGTII B0JZB7_DANRE B0JZB7_DANRE AFVLLYPDHMHLNRGNHEDHIMNLRYGFTREVMQKYKTHGREILQLLQDVFSLLPVATVI Q4SHR7_TETNG Q4SHR7_TETNG AYLLLYPDYMHLNRGNHEDHLMNLRYGFTKEVMQKYKIHGCEILQLFQDVFSLLPVATII MATCH .*:** .:*.******.::*******:*: **: ** .**: ::..: **:.*:: CONSENSUS ???LVYP???HLNRGNHED???NLRYGFTKE???KYK?HG??IL??L?????WLP??T??

PPE2_HUMAN PPE2_HUMAN DEKVLILHGGVSDITDLELLDKIERSK------IVSTMRCKTRQKSEKQMEEKRRANQKS PPE2_MOUSE PPE2_MOUSE DEKVLVLHGGVSDKTDLELLAKLDRHK------IVSTMRCKTRKESENREEQKRKDNQTS Q4RU11_TETNG Q4RU11_TETNG DQKVLVLHGGISDLTDLGLLAKLDRHN------YVSALRPPKRRGYNSAGTSIDSDVDED Q4SQB1_TETNG Q4SQB1_TETNG DHKVLIVHGGISDTTDLDAIARVDRHK------YVSALRPPKLK--NQAANEKRAGAAGP A8K870_HUMAN A8K870_HUMAN DNEILVIHGGISETTDLNLLHRVERNK------MKSVLIPPTETNRDHDTDSKHNKVGVT B7Z6R7_HUMAN B7Z6R7_HUMAN DNEILVIHGGISETTDLNLLHRVERNK------MKSVLIPPTETNRDHDTDSKHNKVGVT B7Z353_HUMAN B7Z353_HUMAN DNEILVIHGGISETTDLNLLHRVERNK------MKSVLIPPTETNRDHDTDSKHNKVGVT B0AZL8_HUMAN B0AZL8_HUMAN DNEILVIHGGISETTDLNLLHRVERNK------MKSVLIPPTETNRDHDTDSKHNKVGVT PPE1_HUMAN PPE1_HUMAN DNEILVIHGGISETTDLNLLHRVERNK------MKSVLIPPTETNRDHDTDSKHNKVGVT Q4R441_MACFA Q4R441_MACFA DNEILVIHGGISETTDLNLLHRVERNK------MKSVLIPPTETNRDNDTDSKHNKVGVT Q4R4Y0_MACFA Q4R4Y0_MACFA DNEILVIHGGISETTDLNLLHRVERNK------MKSVLIPPTETNRDNDTDSKHNKVGVT PPE1_RAT PPE1_RAT DNEILVIHGGISESTDLNILQQLQRNK------MKSVLMPPMSTNQECNIKKNKAGPS-- PPE1_MOUSE PPE1_MOUSE DNEILVIHGGISESTDLNTLHQLQRNK------MKSVLMPPVLGNQETGEKRNKSASN-- Q3UQZ5_MOUSE Q3UQZ5_MOUSE DNEILVIHGGISESTDLNTLHQ-------------------------------------- B0JZB7_DANRE B0JZB7_DANRE DNKVLIVHGGISDKTDLDFLSTVERHK------VKSALRLPKRSTDHLTVRSCSRSSSRN Q4SHR7_TETNG Q4SHR7_TETNG DGKILIVHGGISDQTDLDFLSALERHKVSHSEKLRHFQIPIINRKRRCRLKRQDSTASNS MATCH * ::*::***:*: *** : CONSENSUS D???L??HGGIS??TDL??L????R?K????????S????????????????????????

PPE2_HUMAN PPE2_HUMAN SAQGPIPWFLPESRSLPSSPLRLGS-YKAQKTSRSSSIPCSGSLDGRELS--RQVRSSVE PPE2_MOUSE PPE2_MOUSE SGQKPTPWFLPQSRSLPSSPFHLGSGFKAYKAGRSCSIPC-GSPNSKELSRRGQVRRSVD Q4RU11_TETNG Q4RU11_TETNG VSCNSKIFQRRTSLT-----------YARPLGTRTSFQNR----SLQDFS--DRIRLPAE Q4SQB1_TETNG Q4SQB1_TETNG MEGRRRVY----TLT-----------YKSTAADHSHKRPR-HSLHSQQLS--GQVNWSVE A8K870_HUMAN A8K870_HUMAN --------------------------FNAHGRIKTNGSPT------------EHLT---- B7Z6R7_HUMAN B7Z6R7_HUMAN --------------------------FNAHGRIKTNGSPT------------EHLT---- B7Z353_HUMAN B7Z353_HUMAN --------------------------FNAHGRIKTNGSPT------------EHLT---- B0AZL8_HUMAN B0AZL8_HUMAN --------------------------FNAHGRIKTNGSPT------------EHLT---- PPE1_HUMAN PPE1_HUMAN --------------------------FNAHGRIKTNGSPT------------EHLT---- Q4R441_MACFA Q4R441_MACFA --------------------------FNAHRRIKTNGSPS------------EHLP---- Q4R4Y0_MACFA Q4R4Y0_MACFA --------------------------FNAHGRIKTNGSPS------------EHLP---- PPE1_RAT PPE1_RAT -----------------------------------EQSAS------------EQLT---- PPE1_MOUSE PPE1_MOUSE --------------------------YVEPRKVEPDKTPS------------EDLT---- Q3UQZ5_MOUSE Q3UQZ5_MOUSE ------------------------------------------------------------ B0JZB7_DANRE B0JZB7_DANRE RGRNSRSSSRHSSRSRRKKL------SKQGSRSSSSSSSSSSSSSMCSPRVSAKNTTRRP Q4SHR7_TETNG Q4SHR7_TETNG SSSSSSSSSSSISLCS----------LKTPPCHTPHRHPSSPTLSCSGSA--FQLPFLDS MATCH CONSENSUS ????????????????????????????????????????????????????????????

PPE2_HUMAN PPE2_HUMAN LELERCRQQAGLLVTGEKEE--PSRSASEADSEAGELRKPTQEEWRQVVDILWSDPMAQE PPE2_MOUSE PPE2_MOUSE LELEQCRQQAGFLGIREKGESLPLAPDADCVADGGGVLEPTPEEWKQVVDILWSDPAAQE Q4RU11_TETNG Q4RU11_TETNG NELELRRR-REF--IFHLSE--SEKTINPAASSDSVKSESLKDEWKQILDLLWSDPMIQD Q4SQB1_TETNG Q4SQB1_TETNG EELKKRRRLAGF--DQSYGE--PQRSDSDSDPESGEATEADEHEWKQIVDILWSDPMPQS A8K870_HUMAN A8K870_HUMAN -----------------------------------------EHEWEQIIDILWSDPRGKN B7Z6R7_HUMAN B7Z6R7_HUMAN -----------------------------------------EHEWEQIIDILWSDPRGKN B7Z353_HUMAN B7Z353_HUMAN -----------------------------------------EHEWEQIIDILWSDPRGKN B0AZL8_HUMAN B0AZL8_HUMAN -----------------------------------------EHEWEQIIDILWSDPRGKN PPE1_HUMAN PPE1_HUMAN -----------------------------------------EHEWEQIIDILWSDPRGKN Q4R441_MACFA Q4R441_MACFA -----------------------------------------KHEWEQIIDILWSDPRGKN Q4R4Y0_MACFA Q4R4Y0_MACFA -----------------------------------------KHEWEQIIDILWSDPRGKN PPE1_RAT PPE1_RAT -----------------------------------------KLEWEQIIDLLWSDPRGKK PPE1_MOUSE PPE1_MOUSE -----------------------------------------KQEWEQIVDILWSDPRGKK Q3UQZ5_MOUSE Q3UQZ5_MOUSE ------------------------------------------------------------ B0JZB7_DANRE B0JZB7_DANRE PPSPTDMLQVPFLDSFVSLE--PPELPRE------------ELEWQQVVDILWSDPKHQN Q4SHR7_TETNG Q4SHR7_TETNG LSAPSPPQH--------------------------------EQEWKQIVDILWSDPKAPN MATCH CONSENSUS ???????????????????????????????????????????EW?Q??DILWSDP????

PPE2_HUMAN PPE2_HUMAN GCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRK----------- PPE2_MOUSE PPE2_MOUSE GCKANAVRGGGCYFGPDVTERLMEKYKLQLLIRSHECKPEGYEFCHNRK----------- Q4RU11_TETNG Q4RU11_TETNG GCIPNEVRGGGCYWGPDVTEEFLNKHNLQLIIRSHECKQEGYEFCHNRKVIGQLPGPQGP Q4SQB1_TETNG Q4SQB1_TETNG GCIPNEVRGGGCYWGPDVTEKVLARHDLQLLVRSHECKQEGYEFCHDRR----------- A8K870_HUMAN A8K870_HUMAN GCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGK----------- B7Z6R7_HUMAN B7Z6R7_HUMAN GCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGK----------- B7Z353_HUMAN B7Z353_HUMAN GCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGK----------- B0AZL8_HUMAN B0AZL8_HUMAN GCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGK----------- PPE1_HUMAN PPE1_HUMAN GCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGK----------- Q4R441_MACFA Q4R441_MACFA GCFPNTGRGGGCYFGPDVTSKILNKYQL-------------------------------- Q4R4Y0_MACFA Q4R4Y0_MACFA GCFPNTGRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGK----------- PPE1_RAT PPE1_RAT GCYPNTSRGGGCYFGPDVTSKVLNKNQLKMVIRSHECKPDGYEICHDGK----------- PPE1_MOUSE PPE1_MOUSE GCYPNTSRGGGCYFGPDVTSKVLSKNQLKMLIRSHECKPDGYEVSHDGK----------- Q3UQZ5_MOUSE Q3UQZ5_MOUSE ------------------------------------------------------------ B0JZB7_DANRE B0JZB7_DANRE GCSPNSFRGGGCYFGPDVTQTLLQKHGLCLLIRSHECKQEGYELCHNGQ----------- Q4SHR7_TETNG Q4SHR7_TETNG GCSPNTFRGGGCYFGPDVTRRLLLQQGLQLLIRSHECKQEGYELCHSGQ----------- MATCH CONSENSUS GC?PN??RGGGCYFGPDVT???L?K??L???IRSHECK??GYE?CH??????????????

PPE2_HUMAN PPE2_HUMAN ---------------VLTIFSASNYYEVGSNRGAYVKLGPALTPHIVQYQANKVTHTLTM PPE2_MOUSE PPE2_MOUSE ---------------VLTIFSASNYYEVGSNRGAYVKLGPALTPHIVQYQANKATHRLTM Q4RU11_TETNG Q4RU11_TETNG RVLPGHQLKTVVFLQVLTLFSASNYYDVGSNRGAYVKLGPNLVPYVIQYQANSMTRELSM Q4SQB1_TETNG Q4SQB1_TETNG ---------------VLTIFSASNYYEVGSNRGAYIRMGHDLIPHFVQYQASKTCRELTL A8K870_HUMAN A8K870_HUMAN ---------------VVTIFSASNYYEEGSNRGAYIKLCSGTTPRFFQYQVTKATCFQPL B7Z6R7_HUMAN B7Z6R7_HUMAN ---------------VVTIFSASNYYEEGSNRGAYIKLCSGTTPRFFQYQVTKATCFQPL B7Z353_HUMAN B7Z353_HUMAN ---------------VVTIFSASNYYEEGSNRGAYIKLCSGTTPRFFQYQVTKATCFQPL B0AZL8_HUMAN B0AZL8_HUMAN ---------------VVTIFSASNYYEEGSNRGAYIKLCSGTTPRFFQYQVTKATCFQPL PPE1_HUMAN PPE1_HUMAN ---------------VVTIFSASNYYEEGSNRGAYIKLCSGTTPRFFQYQVTKATCFQPL Q4R441_MACFA Q4R441_MACFA ------------------------------------------------------------ Q4R4Y0_MACFA Q4R4Y0_MACFA ---------------VVTIFSASNYYEEGSNRGAYIKLCSGTAPRFFQYQVTKATCFQPL PPE1_RAT PPE1_RAT ---------------VITVFSASNYYEEGSNRGAYIRLSYGTSPQFFQYQVTSTSCLNPL PPE1_MOUSE PPE1_MOUSE ---------------VITVFSASNYYEEGSNRGAYIRLSYGTMPQFFQYQVTSTSCLNPL Q3UQZ5_MOUSE Q3UQZ5_MOUSE ------------------------------------------------------------ B0JZB7_DANRE B0JZB7_DANRE ---------------VITIFSASNYYEEGSNRGAYVKLGPELVPRFFQYQVSRSTRKLTL Q4SHR7_TETNG Q4SHR7_TETNG ---------------VITIFSASNYYEEGSNRGAYIKVGRELMPRFYQYQVSRFTRKLTL MATCH CONSENSUS ???????????????V?T?FSASNYYE?GSNRGAY????????P???QYQ??????????

PPE2_HUMAN PPE2_HUMAN RQRISRVEESALRALREKLFAHSSDLLSEFKKHDADKVGLITLSDWAAAVESVLHLGLPW PPE2_MOUSE PPE2_MOUSE RQRISRVEESALRALRQKLFAHSSDLLVEFRKRDPDESGVITLSDWATAVESVLHLGLPW Q4RU11_TETNG Q4RU11_TETNG RQSIGRTERSALKVLREQLFAHKSDLISAFKQFDTENTGLVSLCDWASAVESVMHLGLPW Q4SQB1_TETNG Q4SQB1_TETNG RQSVGRTERSALRALKEQLFVHKSDLMSAFQEFDPNNTGMISLRHWASATERVLNLGLPW A8K870_HUMAN A8K870_HUMAN RQRVDTMENSAIKILRERVISRKSDLTRAFQLQDHRKSGKLSVSQWAFCMENILGLNLPW B7Z6R7_HUMAN B7Z6R7_HUMAN RQRVDTMENSAIKILRERVISRKSDLTRAFQLQDHRKSGKLSVSQWAFCMENILGLNLPW B7Z353_HUMAN B7Z353_HUMAN RQRVDTMENSAIKILRERVISRKSDLTRAFQLQDHRKSGKLSVSQWAFCMENILGLNLPW B0AZL8_HUMAN B0AZL8_HUMAN RQRVDTMENSAIKILRERVISRKSDLTRAFQLQDHRKSGKLSVSQWAFCMENILGLNLPW PPE1_HUMAN PPE1_HUMAN RQRVDTMENSAIKILRERVISRKSDLTRAFQLQDHRKSGKLSVSQWAFCMENILGLNLPW Q4R441_MACFA Q4R441_MACFA ------------------------------------------------------------ Q4R4Y0_MACFA Q4R4Y0_MACFA RQRVYTMESSAIKILKERVISRKSDLTRAFQLQDHRKSGKLSLSQWAFCMENILGLNLPW PPE1_RAT PPE1_RAT YQRVNAMEFSAFRILKERMIARKTDLINAFELRDHSRTGKISLAQWAFSMESILGLNLPW PPE1_MOUSE PPE1_MOUSE HQRMNAMESSAFKILKEKMISRKTDLINAFELRDHSRSGRISLAEWAFSMENILGLNLPW Q3UQZ5_MOUSE Q3UQZ5_MOUSE ------------------------------------------------------------ B0JZB7_DANRE B0JZB7_DANRE HQRVRVAEGSALRALKEKLYAHRSELMAAFQQYDIDNTGRISTSEWAQVVESVLRLDLPW Q4SHR7_TETNG Q4SHR7_TETNG TQRVRAAEGSALRALKEKLFTHRSELILGFQQYDHNNTGTILVSEWAQVLETGLRLELPW MATCH CONSENSUS ?Q?????E?SA???L?E????????L???F???D????G??????WA???E??L?L?LPW

PPE2_HUMAN PPE2_HUMAN RMLRPQLVNS-SADNMLEYKSWLKNLAKEQLSRENIQSSL---LETLYRNRSNLETIFRI PPE2_MOUSE PPE2_MOUSE RMLRPQLVNS-SADNVLEYRSWLDSLAKEQLSRENIQSSL---LEKLYRNRSNLETIFRI Q4RU11_TETNG Q4RU11_TETNG RMLSSQLSTTKSGDGMISYHEWFDELAIKGANIDGLQQTLYRHLETLYRHRSTLETIFRI Q4SQB1_TETNG Q4SQB1_TETNG RVLRPQLVSS-TESGMVDYQQWIREFSITEPKLEMADNSI---LETMYRNHCNLETIFRI A8K870_HUMAN A8K870_HUMAN RSLSSNLVNI-DQNGNVEYMSSSQNIRIEKP-VQEAHSTL---VETLYRYRSDLEIIFNA B7Z6R7_HUMAN B7Z6R7_HUMAN RSLSSNLVNI-DQNGNVEYMSSFQNIRIEKP-VQEAHSTL---VETLYRYRSDLEIIFNA B7Z353_HUMAN B7Z353_HUMAN RSLSSNLVNI-DQNGNVEYMSSFQNIRIEKP-VQEAHSTL---VETLYRYRSDLEIIFNA B0AZL8_HUMAN B0AZL8_HUMAN RSLSSNLVNI-DQNGNVEYMSSFQNIRIEKP-VQEAHSTL---VETLYRYRSDLEIIFNA PPE1_HUMAN PPE1_HUMAN RSLSSNLVNI-DQNGNVEYMSSFQNIRIEKP-VQEAHSTL---VETLYRYRSDLEIIFNA Q4R441_MACFA Q4R441_MACFA --MKPGVTNL-------------------------------------------------- Q4R4Y0_MACFA Q4R4Y0_MACFA RSLSSNLVNI-DKNGNVEYMSSFQNIHIEKP-VEEAHSTL---VETLYRYRSDLEIIFNA PPE1_RAT PPE1_RAT RSLSSHLVST-DSSGSVDYMSSFDDIHIEKP-MKDMKSDL---IETMYRYRSDLKIIFNI PPE1_MOUSE PPE1_MOUSE RSLSSHLVTI-DSSGSVDYMSSFDDIRIEKP-TKDMKSNL---TETMYRYRSDLKIIFNI Q3UQZ5_MOUSE Q3UQZ5_MOUSE ------------------------------------------------------------ B0JZB7_DANRE B0JZB7_DANRE RTLRPRLARL-GTDGNVEYESCFEDISPGEP-IPPVTPNL---AETLYRYRTDLEIIFNI Q4SHR7_TETNG Q4SHR7_TETNG RTLRPHLARL-ASDGRVEYHSCFEDMEPGIP-LVQVTPNL---AEALFRYRKDIEIIFNI MATCH CONSENSUS R?L???L???????????Y????????????????????L????E??YR?R??L??IF??

PPE2_HUMAN PPE2_HUMAN IDSDHSGFISLDEFRQTWKLFSSHMNIDITDDCICDLARSIDFNKDGHIDINEFLEAFRL PPE2_MOUSE PPE2_MOUSE IDSDHSGFISLDEFRQTWKLFSSHMSIDITDDGICDLARSIDFNKDGHIDINEFLEAFRL Q4RU11_TETNG Q4RU11_TETNG IDKDNSGFISMEDFRKTWKLLSIYLKMEISDDAISDLAVTIDSNQDGSIDIDEFMEAFRL Q4SQB1_TETNG Q4SQB1_TETNG IDTDHSGLISFEEFHQTWKLLSSHLKMEISDKAVTDLAQSIDFNKDGSIDINEFMEAFRL A8K870_HUMAN A8K870_HUMAN IDTDHSGLISVEEFRAMWKLFSSHYNVHIDDSQVNKLANIMDLNKDGSIDFNEFLKAFYV B7Z6R7_HUMAN B7Z6R7_HUMAN IDTDHSGLISVEEFRAMWKLFSSHYNVHIDDSQVNKLANIMDLNKDGSIDFNEFLKAFYV B7Z353_HUMAN B7Z353_HUMAN IDTDHSGLISVEEFRAMWKLFSSHYNVHIDDSQVNKLANIMDLNKDGSIDFNEFLKAFYV B0AZL8_HUMAN B0AZL8_HUMAN IDTDHSGLISVEEFRAMWKLFSSHYNVHIDDSQVNKLANIMDLNKDGSIDFNEFLKAFYV PPE1_HUMAN PPE1_HUMAN IDTDHSGLISVEEFRAMWKLFSSHYNVHIDDSQVNKLANIMDLNKDGSIDFNEFLKAFYV Q4R441_MACFA Q4R441_MACFA ----------------------------------------------G------------- Q4R4Y0_MACFA Q4R4Y0_MACFA IDTDHSGLISIEEFRAMWKLFSAHYHVLIDDSQVNKLANIMDLNKDGSIDFNEFLKAFYV PPE1_RAT PPE1_RAT IDTDQSGLISMDEFRTMWKLFNAHYKVHIDDSQIDELASTMDSNKDGNIDFNEFLRAFYV PPE1_MOUSE PPE1_MOUSE IDSDQSGLISMDEFRTMWKLFNAHYKAHIDDSQIDELASIVDFNKDGNIDFNEFLKAFYV Q3UQZ5_MOUSE Q3UQZ5_MOUSE ------------------------------------------------------------ B0JZB7_DANRE B0JZB7_DANRE IDKDHSGQISIEEFRQTWKLFSSHLGVAVNDQTIDDMARSIDFNKDGSIDFTEFLEAFRV Q4SHR7_TETNG Q4SHR7_TETNG IDKDHSGLISIEEFRHTWHLFSAHLGVKIDNRAIDDLARSIDFNKDGNIDFNEFLEAFRV MATCH CONSENSUS ID?D?SG?IS??EFR??WKL???H????I?D?????LA???D?NKDG?ID??EF??AF??

PPE2_HUMAN PPE2_HUMAN VEKSCPEGDASECPQATNAKDSGCSSPGAH PPE2_MOUSE PPE2_MOUSE VEQSCLEGHASACLQSTDTAESGHSSPGPC Q4RU11_TETNG Q4RU11_TETNG TDKK-------------------------- Q4SQB1_TETNG Q4SQB1_TETNG VHLST------------------------- A8K870_HUMAN A8K870_HUMAN VHRCEDLMKPDVTNLG-------------- B7Z6R7_HUMAN B7Z6R7_HUMAN VHRYEDLMKPDVTNLG-------------- B7Z353_HUMAN B7Z353_HUMAN VHRYEDLMKPDVTNLG-------------- B0AZL8_HUMAN B0AZL8_HUMAN VHRYEDLMKPDVTNLG-------------- PPE1_HUMAN PPE1_HUMAN VHRYEDLMKPDVTNLG-------------- Q4R441_MACFA Q4R441_MACFA ------------------------------ Q4R4Y0_MACFA Q4R4Y0_MACFA VHRYEDLMKPGVTNLG-------------- PPE1_RAT PPE1_RAT VHKYETPESPLNK----------------- PPE1_MOUSE PPE1_MOUSE VHKYDKPGTSLA------------------ Q3UQZ5_MOUSE Q3UQZ5_MOUSE ------------------------------ B0JZB7_DANRE B0JZB7_DANRE VHKLDVKEQQQG------------------ Q4SHR7_TETNG Q4SHR7_TETNG VHK--------------------------- MATCH CONSENSUS V?????????????????????????????


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