Alignment of the gene Family HBG008967 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
Q98966_NOTVI Q98966_NOTVI ------------------------------------------MPPKY------------P RB_CHICK RB_CHICK -----------------------------------------MPPKPLRRAGAARSQRTSP B4DTN0_HUMAN B4DTN0_HUMAN ----------------------------------------------------MPPKTPPP Q9BDQ3_PANTR Q9BDQ3_PANTR ------------------------------------------------------------ Q59HH0_HUMAN Q59HH0_HUMAN SGEDGACPDVRARRPPRRSSTARWLPPRKGVMPPKTPRKTAATAAAAAAEPPAPPPPPPP RB_HUMAN RB_HUMAN -------------------------------MPPKTPRKTAATAAAAAAEPPAPPPPPPP B4DRB3_HUMAN B4DRB3_HUMAN ------------------------------------------------------------ Q08E68_BOVIN Q08E68_BOVIN -------------------------------MPPKTPRRAAAAAAAAAAEPPPPPLPPPP Q9N122_CANFA Q9N122_CANFA ------------------------------------------------------------ RB_RAT RB_RAT -----------------------------------------------------------P Q3UJG1_MOUSE Q3UJG1_MOUSE ------------------------------------------------------------ RB_MOUSE RB_MOUSE -------------------------------------MPPKAPRRAAAAEPPPPPPPPPR Q3URY9_MOUSE Q3URY9_MOUSE -------------------------------------MPPKAPRRAAAAEPPPPPPPPPR Q4VA62_MOUSE Q4VA62_MOUSE -------------------------------------MPPKAPRRAAAAEPPPPPPPPPR Q3V0V3_MOUSE Q3V0V3_MOUSE ------------------------------------------------------------ Q9YGE5_ONCMY Q9YGE5_ONCMY ------------------------------------------MPPKKRNSGAAQNKEMKP Q8JG55_DANRE Q8JG55_DANRE ------------------------------------------------------------ A0JMQ4_DANRE A0JMQ4_DANRE ------------------------------------------MPPKKRSSGTPQKKELK- A8WGI9_DANRE A8WGI9_DANRE ------------------------------------------MPPKKRSSGTPQKKELK- Q4S8W2_TETNG Q4S8W2_TETNG ------------------------------------------------------------ Q98SK2_ORYLA Q98SK2_ORYLA ------------------------------------------MPPKKRNSGTAQSKEPKP Q1X7L8_LIMLI Q1X7L8_LIMLI ------------------------------------------------------------ A3DUJ4_XIPMA A3DUJ4_XIPMA ------------------------------------------MPPKKRHSGTTQNKEPKP Q5J3Q9_FUNHE Q5J3Q9_FUNHE ------------------------------------------MPPKKRHSGLTGSREPKP MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q98966_NOTVI Q98966_NOTVI PQVRKGDSSSSAVQSQEEHRQWLDDADFTLLCDSLKVSDAVREGSWKIWQKVSADGCE-- RB_CHICK RB_CHICK EGGAGTASPPGGTRL------EVGEAEFVALCDALKAPDSVREKAWMTYQSLAAADGA-S B4DTN0_HUMAN B4DTN0_HUMAN EEDPEQDSGPEDLPLVRLEFEETEEPDFTALCQKLKIPDHVRERAWLTWEKVSSVDGVLG Q9BDQ3_PANTR Q9BDQ3_PANTR -----------------LEFEETEEPDFTALCQKLKIPDHVRERAWLTWEKVSSVDGVLG Q59HH0_HUMAN Q59HH0_HUMAN EEDPEQDSGPEDLPLVRLEFEETEEPDFTALCQKLKIPDHVRERAWLTWEKVSSVDEVLG RB_HUMAN RB_HUMAN EEDPEQDSGPEDLPLVRLEFEETEEPDFTALCQKLKIPDHVRERAWLTWEKVSSVDGVLG B4DRB3_HUMAN B4DRB3_HUMAN ------------------------------------------------------------ Q08E68_BOVIN Q08E68_BOVIN EEDPEQDSGSEDLPLARLEFEETEEPDFTALCQKLKLPDHVRERAWLTWEKVSSVDGVLE Q9N122_CANFA Q9N122_CANFA ------------------------------------------------------------ RB_RAT RB_RAT EDDPAQDSDPEELPLIRLEFEKIEEPEFIALCQKLKVPDHVRERAWLTWEKVSSVDGILE Q3UJG1_MOUSE Q3UJG1_MOUSE ------------------------------------------------------------ RB_MOUSE RB_MOUSE EDDPAQDSGPEELPLARLEFEEIEEPEFIALCQKLKVPDHVRERAWLTWEKVSSVDGILE Q3URY9_MOUSE Q3URY9_MOUSE EDDPAQDSGPEELPLARLEFEEIEEPEFIALCQKLKVPDHVRERAWLTWEKVSSVDGILE Q4VA62_MOUSE Q4VA62_MOUSE EDDPAQDSGPEELPLARLEFEEIEEPEFIALCQKLKVPDHVRERAWLTWEKVSSVDGILE Q3V0V3_MOUSE Q3V0V3_MOUSE ------------------------------------------------------------ Q9YGE5_ONCMY Q9YGE5_ONCMY SIKNASP--DKENPDLSIEKHQEKDADFMTLCQSLQVIDAVCDRAWTIWKAVQASVDK-- Q8JG55_DANRE Q8JG55_DANRE ------------------------------------------------------------ A0JMQ4_DANRE A0JMQ4_DANRE GSLKSRSPDSGDNAVLSPERHKDKDPEFVFLSEELQSTNSICDHAWRIWEREIRSMDK-T A8WGI9_DANRE A8WGI9_DANRE GSLKSRSPDSGDNAVLSPERHKDKDPEFVFLSEELQSTNSICDHAWRIWEREIRSMDK-T Q4S8W2_TETNG Q4S8W2_TETNG ------------------------------------------------------VLNA-- Q98SK2_ORYLA Q98SK2_ORYLA SSDKSF-ADKKGSPEFSLNKHTEKDVEFVTLCKSLHATDSVCERAWSLWKTVQDVMED-- Q1X7L8_LIMLI Q1X7L8_LIMLI ------------------------------------------------------------ A3DUJ4_XIPMA A3DUJ4_XIPMA SADSASPPDKQDSPELSEKKHREKHAEFVSLCKSLHVSDLVCDRAWTLWESVRESMDK-- Q5J3Q9_FUNHE Q5J3Q9_FUNHE DGDSASSPDKQESPELSEEKHRDKNAEFVSLCKSLHVSDLLCDRAWLLWRTVQESMDK-- MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q98966_NOTVI Q98966_NOTVI -RIIRNEKVLGICIFLAAVELNDLTFTITELLKSTHLNVNMFTGYIKEMDISMDTITTKV RB_CHICK RB_CHICK AYNKKKKETWGVCIFIVAIDLDEMTFTFTELLKSLSISVCTFFQFLKEVDVNMDTVSTKV B4DTN0_HUMAN B4DTN0_HUMAN GYIQKKKELWGICIFIAAVDLDEMSFTFTELQKNIEISVHKFFNLLKEIDT-----STKV Q9BDQ3_PANTR Q9BDQ3_PANTR GYIQKKKELWGICIFIAAVDLDEMSFTFTELQKNIEISVHKFFNLLKEIDT-----STKV Q59HH0_HUMAN Q59HH0_HUMAN GYIQKKKELWGICIFIAAVDLDEMSFTFTELQKNIEISVHKFFNLLKEIDT-----STKV RB_HUMAN RB_HUMAN GYIQKKKELWGICIFIAAVDLDEMSFTFTELQKNIEISVHKFFNLLKEIDT-----STKV B4DRB3_HUMAN B4DRB3_HUMAN -----------------------MSFTFTELQKNIEISVHKFFNLLKEIDT-----STKV Q08E68_BOVIN Q08E68_BOVIN GYVQKKKELWGICIFIAAVDLDEMPFTFTELQKNIETSVYKFFDLLKEIDT-----STKV Q9N122_CANFA Q9N122_CANFA ------------------------------------------------------------ RB_RAT RB_RAT GYIQKKKELWGICIFIAAVDLDEMPFTFTELQKSIETSVYKFFDLLKEIDT-----STKV Q3UJG1_MOUSE Q3UJG1_MOUSE ------------------------------------------------------------ RB_MOUSE RB_MOUSE GYIQKKKELWGICIFIAAVDLDEMPFTFTELQKSIETSVYKFFDLLKEIDT-----STKV Q3URY9_MOUSE Q3URY9_MOUSE GYIQKKKELWGICIFIATVDLDEMPFTFTELQKSIETSVYKFFDLLKEIDT-----STKV Q4VA62_MOUSE Q4VA62_MOUSE GYIQKKKELWGICIFIAAVDLDEMPFTFTELQKSIETSVYKFFDLLKEIDT-----STKV Q3V0V3_MOUSE Q3V0V3_MOUSE ------------------------------------------------------------ Q9YGE5_ONCMY Q9YGE5_ONCMY -VLDTQKKLWAACLFVAVIDLEIASFTFTQILKAVDLNVKQFLGLLKKMDVNLDTISTKV Q8JG55_DANRE Q8JG55_DANRE ------------------------------------------------------------ A0JMQ4_DANRE A0JMQ4_DANRE NMPYSNRQQWGACLFIAGMELEGINLTFTQFLKAVGLSVKQFISLVRKMDVNVDTISPKV A8WGI9_DANRE A8WGI9_DANRE NMPYSNRQQWGACLFIAGMELEGINLTFTQFLKAVGLSVKQFISLVRKMDVNVDTISPKV Q4S8W2_TETNG Q4S8W2_TETNG -FQDSQKSLWGSCLFASVTDMDIACFTLTQLLKAVSLNVKEFLALVRKLDVNMDTISTKV Q98SK2_ORYLA Q98SK2_ORYLA -VDANQKRLWGSCLFVTATDMDATCFTLTEVLKAVNINVKQFVDLVRQLDVNLDTISTKV Q1X7L8_LIMLI Q1X7L8_LIMLI ------------------------------------------------------------ A3DUJ4_XIPMA A3DUJ4_XIPMA -VPGSQQRLWGACLFVIITDMDTGSFTVTQVLKAVSLNLKQFLALVRQLDVNLDTISMKV Q5J3Q9_FUNHE Q5J3Q9_FUNHE -APGSQERLWAACLFVTVTDMDVGCFTVTQVLKAVRLNLKQFLDVVRQLDVNLDTITTKV MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q98966_NOTVI Q98966_NOTVI NNAVTRLKTKYNTLCTLYQKFQRLFELIFIKEPSNVQISSDI-----SPAALFKILWITF RB_CHICK RB_CHICK DSTVSRLKKKYDVLLALYHKFERTCGLIYLEQPSSEISAEL------SSVLVLKNYWITF B4DTN0_HUMAN B4DTN0_HUMAN DNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSSISTEI------NSALVLKVSWITF Q9BDQ3_PANTR Q9BDQ3_PANTR DNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSLISTEI------NSALVLKVSWITF Q59HH0_HUMAN Q59HH0_HUMAN DNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSSISTEI------NSALVLKVSWITF RB_HUMAN RB_HUMAN DNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSSISTEI------NSALVLKVSWITF B4DRB3_HUMAN B4DRB3_HUMAN DNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSSISTEI------NSALVLKVSWITF Q08E68_BOVIN Q08E68_BOVIN DNAMSRLLKKYNVLCALYSKLERTCELIYLTQPSSSISTEI------NSMLVLKVSWITF Q9N122_CANFA Q9N122_CANFA ------------------------------------------------------------ RB_RAT RB_RAT DNAVSRLLKKYNVLCALYSKLERTCGLIYLTQPSSGLSTEI------NSMLVLKVSWITF Q3UJG1_MOUSE Q3UJG1_MOUSE -----------------------------------ALSTEI------NSMLVLKISWITF RB_MOUSE RB_MOUSE DNAMSRLLKKYNVLCALYSKLERTCELIYLTQPSSALSTEI------NSMLVLKISWITF Q3URY9_MOUSE Q3URY9_MOUSE DNAMSRLLKKYNVLCALYSKLERTCELIYLTQPSSALSTEI------NSMLVLKISWITF Q4VA62_MOUSE Q4VA62_MOUSE DNAMSRLLKKYNVLCALYSKLERTCELIYLTQPSSALSTEI------NSMLVLKISWITF Q3V0V3_MOUSE Q3V0V3_MOUSE ------------------------------------------------------------ Q9YGE5_ONCMY Q9YGE5_ONCMY NSAVTRLEKKYDVSRALYQRFEKTCSKIYAEDSEA------------KGKEILRSCWTMF Q8JG55_DANRE Q8JG55_DANRE ------------------------------------------------------------ A0JMQ4_DANRE A0JMQ4_DANRE NSAVTRLENKYDVTLALYQRFVKTCEKIFAEPDNA------------KRKELWESSWTMF A8WGI9_DANRE A8WGI9_DANRE NSAVTRLENKYDVTLALYQRFVKTCEKIFAEPDNA------------KRKELWESSWTMF Q4S8W2_TETNG Q4S8W2_TETNG NAALSSLEKKYDVMLALYQRFEKTCKSVFASVSDNCRCKSDWLLSFSREKEIIRSCWTMF Q98SK2_ORYLA Q98SK2_ORYLA NSALMRVEKKYDVMLALYQRFEKTCKKIFASTPDK------------KERATMRTCWTMF Q1X7L8_LIMLI Q1X7L8_LIMLI ------------------QRFEKTCKKIFTLVSDG------------TERETMRNCWTMF A3DUJ4_XIPMA A3DUJ4_XIPMA NSALTRLEKKYDVMLALYQRFEKTCKNIFVLTSDG------------RERETMRTCWTMF Q5J3Q9_FUNHE Q5J3Q9_FUNHE NSRLTRLEKKYDVMLALYQRFEKTCKSIFVLTPDG------------RERETMRTCWTMF MATCH CONSENSUS ????????????????????????????????????????????????????????W??F

Q98966_NOTVI Q98966_NOTVI LLVKGSVLQMEDDLVISFQLLLCVFTHYIKILPLPLLREPYKSAISGKSDKAQTRSSRRG RB_CHICK RB_CHICK LLAKGKVLQMEDDLVISFQLLLCVLDYFIKLSPPAMLKEPYKSAVTALTVNGSTRTPRRG B4DTN0_HUMAN B4DTN0_HUMAN LLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYKTAVIPINGSP--RTPRRG Q9BDQ3_PANTR Q9BDQ3_PANTR LLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPVLLKEPYKTAVIPINGSP--RTPRRG Q59HH0_HUMAN Q59HH0_HUMAN LLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYKTAVIPINGSP--RTPRRG RB_HUMAN RB_HUMAN LLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYKTAVIPINGSP--RTPRRG B4DRB3_HUMAN B4DRB3_HUMAN LLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYKTAVIPINGSP--RTPRRG Q08E68_BOVIN Q08E68_BOVIN LLAKGQVLQMEDDLVISFQLMLCVLDYFIKLSPPALLKDPYKTAVIPINGSP--RTPRRG Q9N122_CANFA Q9N122_CANFA ------------------------------------------------------------ RB_RAT RB_RAT LLAKGEVVQMEDDLVISFQLMLCVLDYFIKLSPPALLREPYKTAATPINGSP--RTPRRG Q3UJG1_MOUSE Q3UJG1_MOUSE LLAKGEVLQMEDDLVISFQLMLCVVDYFIKFSPPALLREPYKTAAIPINGSP--RTPRRG RB_MOUSE RB_MOUSE LLAKGEVLQMEDDLVISFQLMLCVVDYFIKFSPPALLREPYKTAAIPINGSP--RTPRRG Q3URY9_MOUSE Q3URY9_MOUSE LLAKGEVLQMEDDLVISFQLMLCVVDYFIKFSPPALLREPYKTAAIPINGSP--RTPRRG Q4VA62_MOUSE Q4VA62_MOUSE LLAKGEVLQMEDDLVISFQLMLCVVDYFIKFSPPALLREPYKTAAIPINGSP--RTPRRG Q3V0V3_MOUSE Q3V0V3_MOUSE ------------------------------------------------------------ Q9YGE5_ONCMY Q9YGE5_ONCMY LLAKGRALQMEDELVISLHLMVCVLEFFIRRCPPSLLQPLYQSVISTAQSPP-TRTSRRN Q8JG55_DANRE Q8JG55_DANRE ------------------------------------------------------------ A0JMQ4_DANRE A0JMQ4_DANRE LLAKGTFLQMEDDLVISFQLLLCVLEFFAKRLSPSLLQSPYNSVVSSSTLSPPTRTSRRN A8WGI9_DANRE A8WGI9_DANRE LLAKGTFLQMEDDLVISFQLLLCVLEFFAKRLSPSLLQSPYKSVVSSSTLSPPTRTSRRN Q4S8W2_TETNG Q4S8W2_TETNG LLAKGRALQMEDDLVISFQLLLCTLEFCIKRCPPELLQPLYKSAISKVHNPP-ARAARRS Q98SK2_ORYLA Q98SK2_ORYLA LLAKGRALQMEDDLVISFQLLLCTLELFIKRSSPELLLPLYKSVVSKAQSPT--RTSRRN Q1X7L8_LIMLI Q1X7L8_LIMLI LLAKGRVLQMEDDLVISFQLLLCMLELFIKRCPSDLLQPIYKSAISKVQSPP-TRTSRRN A3DUJ4_XIPMA A3DUJ4_XIPMA LLAKGRALQMEDDLVISFQLLLCTLELFIKRCSSDQLQSLYQSAISKVLSPP-TRTSRRN Q5J3Q9_FUNHE Q5J3Q9_FUNHE LLAKGRALQMEDDLVISFQLLLCTLELIIKRCSPDQLQPLYQSAVTKVQSPP-TRTSRRS MATCH CONSENSUS LLAKG??LQMEDDLVISFQL?LC??????K??????L???Y?????????????R??RR?

Q98966_NOTVI Q98966_NOTVI RNRNPHLSKQVESD-EVFEILCKENGCNMDEV---KNINIT------------------- RB_CHICK RB_CHICK QNRNARASKQIDTDTKVIEILCKEHDCNLDEV---KNVYFT------------------- B4DTN0_HUMAN B4DTN0_HUMAN QNRSARIAKQLENDTRIIEVLCKEHECNIDEV---KNVYFK------------------- Q9BDQ3_PANTR Q9BDQ3_PANTR QNRSARIAKQLENDTRIIEVLCKEHECNIDEV---KNVYFK------------------- Q59HH0_HUMAN Q59HH0_HUMAN QNRSARIAKQLENDTRIIEVLCKEHECNIDEV---KNVYFK------------------- RB_HUMAN RB_HUMAN QNRSARIAKQLENDTRIIEVLCKEHECNIDEV---KNVYFK------------------- B4DRB3_HUMAN B4DRB3_HUMAN QNRSARIAKQLENDTRIIEVLCKEHECNIDEV---KNVYFK------------------- Q08E68_BOVIN Q08E68_BOVIN QNRSARIAKQLENDTRIIEVLCKEHECNIDEV---KNVYFK------------------- Q9N122_CANFA Q9N122_CANFA ------------------------------------------------------------ RB_RAT RB_RAT QNRSARIAKQLESDTRTIEVLCKEHECNVDEV---KNVYFK------------------- Q3UJG1_MOUSE Q3UJG1_MOUSE QNRSARIAKQLENDTRIIEVLCKEHECNIDEV---KNVYFK------------------- RB_MOUSE RB_MOUSE QNRSARIAKQLENDTRIIEVLCKEHECNIDEV---KNVYFK------------------- Q3URY9_MOUSE Q3URY9_MOUSE QNRSARIAKQLENDTRIIEVLCKEHECNIDEV---KNVYFK------------------- Q4VA62_MOUSE Q4VA62_MOUSE QNRSARIAKQLENDTRIIEVLCKEHECNIDEV---KNVYFK------------------- Q3V0V3_MOUSE Q3V0V3_MOUSE ------------------------------------------------------------ Q9YGE5_ONCMY Q9YGE5_ONCMY QSKAKPRQAPPEVDVQLLETLCKENDCSVEEV---KSVYQT------------------- Q8JG55_DANRE Q8JG55_DANRE ------------------------------------------------------------ A0JMQ4_DANRE A0JMQ4_DANRE QGKSKPRPA--EMDMQLLETLCKEGDCSVDEV---KNVYQS------------------- A8WGI9_DANRE A8WGI9_DANRE QGKSKPRPA--EMDMQLLETLCKEGDCSVDEV---KNVYQS------------------- Q4S8W2_TETNG Q4S8W2_TETNG QSKAKSRPPESEVDLQLLKTLCKENDCNSEEVGGPRPVFNTYTKVKCLVFARCVHHLFYP Q98SK2_ORYLA Q98SK2_ORYLA QSKAKSRVVESEVNVELLETLCKDNECNAEEV---KNVYQT------------------- Q1X7L8_LIMLI Q1X7L8_LIMLI QSKVKSRPPEPEMDVQLLETLCKENECNAEEV---KNVYQT------------------- A3DUJ4_XIPMA A3DUJ4_XIPMA QSKAKSRPSEPEVDAQLLETLCKDNECNFEEV---KNVYQT------------------- Q5J3Q9_FUNHE Q5J3Q9_FUNHE QSKAKSRPAEPEVDARLLETLCKDNECNIEEV---KNVYNT------------------- MATCH CONSENSUS Q??????????E?D????E?LCK???C???EV???K?V??????????????????????

Q98966_NOTVI Q98966_NOTVI ------------TFVPFLDSVGISTTNGIPEE---------------------------- RB_CHICK RB_CHICK ------------SFIPFLNSLGVVASNGLPEV---------------------------- B4DTN0_HUMAN B4DTN0_HUMAN ------------NFIPFMNSLGLVTSNGLPEV---------------------------- Q9BDQ3_PANTR Q9BDQ3_PANTR ------------NFIPFMNSLGLVTSNGLPEV---------------------------- Q59HH0_HUMAN Q59HH0_HUMAN ------------NFIPFMNSLGLVTSNGLPEV---------------------------- RB_HUMAN RB_HUMAN ------------NFIPFMNSLGLVTSNGLPEV---------------------------- B4DRB3_HUMAN B4DRB3_HUMAN ------------NFIPFMNSLGLVTSNGLPEV---------------------------- Q08E68_BOVIN Q08E68_BOVIN ------------NFIPFMNSLGIVASNGLPEV---------------------------- Q9N122_CANFA Q9N122_CANFA ------------------------------------------------------------ RB_RAT RB_RAT ------------NFIPFISSLGIVSSNGLPEL---------------------------- Q3UJG1_MOUSE Q3UJG1_MOUSE ------------NFIPFINSLGIVSSNGLPEV---------------------------- RB_MOUSE RB_MOUSE ------------NFIPFINSLGIVSSNGLPEV---------------------------- Q3URY9_MOUSE Q3URY9_MOUSE ------------NFIPFINSLGIVSSNGLPEV---------------------------- Q4VA62_MOUSE Q4VA62_MOUSE ------------NFIPFINSLGIVSSNGLPEV---------------------------- Q3V0V3_MOUSE Q3V0V3_MOUSE ------------------------------------------------------------ Q9YGE5_ONCMY Q9YGE5_ONCMY ------------SFSAFLDSMSLSGTRDLPQA---------------------------- Q8JG55_DANRE Q8JG55_DANRE ------------------------------------------------------------ A0JMQ4_DANRE A0JMQ4_DANRE ------------TFCAFLDSVGLLGLQGLPPM---------------------------- A8WGI9_DANRE A8WGI9_DANRE ------------TFCAFLDSVGLLGLQGLPPM---------------------------- Q4S8W2_TETNG Q4S8W2_TETNG LIVATGEERVPDKFLSFSGLTRSVWSPTFPSEQVCDSCWLLSCIARLFVVTYMMSEKCVL Q98SK2_ORYLA Q98SK2_ORYLA ------------SLSAFLDLMDLPIPDFLG------------------------------ Q1X7L8_LIMLI Q1X7L8_LIMLI ------------SFAAFLESL-VFRFPDFPQV---------------------------- A3DUJ4_XIPMA A3DUJ4_XIPMA ------------SFLAFLDSTDLSRSIDFPQV---------------------------- Q5J3Q9_FUNHE Q5J3Q9_FUNHE ------------SFLAFLDSMDLSRAAGVPQA---------------------------- MATCH CONSENSUS ?????????????F??F????????????P??????????????????????????????

Q98966_NOTVI Q98966_NOTVI -------PVLSKQYEDLYFNSKDLDARLFLDDDETLQPNMGGCVELEKTPQKNDP-EEMN RB_CHICK RB_CHICK -------DVLSKQYDELYLKNKDIDARLFLDHDETLQPDVIACSQLERTPRKNNPDEEVN B4DTN0_HUMAN B4DTN0_HUMAN -------ENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKSNLDEEVN Q9BDQ3_PANTR Q9BDQ3_PANTR -------ENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKSNLDEEVN Q59HH0_HUMAN Q59HH0_HUMAN -------ENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKSNLDEEVN RB_HUMAN RB_HUMAN -------ENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKSNLDEEVN B4DRB3_HUMAN B4DRB3_HUMAN -------ENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKSNLDEEVN Q08E68_BOVIN Q08E68_BOVIN -------ENLSKQYEEIYLKNKDLDARLFLDHDKTLQADPTDSFEMQRTPRKSNPDEEVN Q9N122_CANFA Q9N122_CANFA ------------------------------------------------------------ RB_RAT RB_RAT -------ESLSKRYEEVYLKSKDLDARLFLDHDKTLQTDTIDSFETERTPRKSNPDEEAN Q3UJG1_MOUSE Q3UJG1_MOUSE -------ESLSKRYEEVYLKNKDLDARLFLDHDKTLQTDPIDSFETERTPRKNNPDEEAN RB_MOUSE RB_MOUSE -------ESLSKRYEEVYLKNKDLDARLFLDHDKTLQTDPIDSFETERTPRKNNPDEEAN Q3URY9_MOUSE Q3URY9_MOUSE -------ESFSKRYEEVYLKNKDLDARLFLDHDKTLQTDPIDSFETERTPRKNNPDEEAN Q4VA62_MOUSE Q4VA62_MOUSE -------ESLSKRYEEVYLKNKDLDARLFLDHDKTLQTDPIDSFETERTPRKNNPDEEAN Q3V0V3_MOUSE Q3V0V3_MOUSE ------------------------------------------------------------ Q9YGE5_ONCMY Q9YGE5_ONCMY -------TDLSKQYEELYFKSRDFDSRLFLDNDETLLTPKVEPMPVERTPRKNMP-EDVV Q8JG55_DANRE Q8JG55_DANRE ------------------------------------------------------------ A0JMQ4_DANRE A0JMQ4_DANRE -------EALSKQYEELYHKSKDFDARLFLSDDETLSPNKIEVSKVEVTPRKNLFAEDIA A8WGI9_DANRE A8WGI9_DANRE -------EALSKQYEELYHKSKDFDARLFLSDDETLSPNKIEVSKVEVTPRKNLFAEDIA Q4S8W2_TETNG Q4S8W2_TETNG RTRIALGKGLDQQYEQHYLRSRDFDGRLFLDGDATVLAPKVDLSQVERTPKK-MSEEDNT Q98SK2_ORYLA Q98SK2_ORYLA -------TDVSKQYQEHYLKSGDIDGRLFFDGDETVLAPKVDISQVGRTPKKTSPDDDGP Q1X7L8_LIMLI Q1X7L8_LIMLI -------HDLDQQYEEHYLKTRDIDGRLFFDRDETVLVPKVEVSEVEMTPKKNLADEDAV A3DUJ4_XIPMA A3DUJ4_XIPMA -------NDVNQQYEELYLKSRDIDGRLFFDGDETVLPPKFEISKVERTPKKNQPEEDGP Q5J3Q9_FUNHE Q5J3Q9_FUNHE -------KDINRLYEEHYLKSRDVDGRLFFDGDESVLPPKVQISQVERTPKKNQPDEDGP MATCH CONSENSUS ?????????????Y???Y????D?D?RLF???D?T?????????????TP?K????E???

Q98966_NOTVI Q98966_NOTVI LIPPQTPVRTAMNTIQNLLNSLASASDQPSPTLKAYFNNCTSNPTRAIQERENNLGQIFK RB_CHICK RB_CHICK HVLPQTPVRAAMNTIQQLMMILNSATDKPSDTLIAYFNNCTVNPEDSILKRVESLGHIFK B4DTN0_HUMAN B4DTN0_HUMAN VIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVKDIGYIFK Q9BDQ3_PANTR Q9BDQ3_PANTR VIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVKDIGYIFK Q59HH0_HUMAN Q59HH0_HUMAN VIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVKDIGYIFK RB_HUMAN RB_HUMAN VIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVKDIGYIFK B4DRB3_HUMAN B4DRB3_HUMAN VIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVKDIGYIFK Q08E68_BOVIN Q08E68_BOVIN MILPQTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKDSILKRVKDIGDVFK Q9N122_CANFA Q9N122_CANFA ----------------QLMVILNSASDQPSENLISYFNNCTVNPKESILKRVKDVGYIFK RB_RAT RB_RAT MVTPHTPVRTVMNTIQQLMVILNSASDQPSENLISYFSNCTVNPKENILKRVKDVGHIFK Q3UJG1_MOUSE Q3UJG1_MOUSE VVTPHTPVRTVMNTIQQLMVILNSASDQPSENLISYFNNCTVNPKENILKRVKDVGHIFK RB_MOUSE RB_MOUSE VVTPHTPVRTVMNTIQQLMVILNSASDQPSENLISYFNNCTVNPKENILKRVKDVGHIFK Q3URY9_MOUSE Q3URY9_MOUSE VVTPHTPVRTVMNTIQQLMVILNSASDQPSENLISYFNNCTVNPKENILKRVKDVGHIFK Q4VA62_MOUSE Q4VA62_MOUSE VVTPHTPVRTVMNTIQQLMVILNSASDQPSENLISYFNNCTVNPKENILKRVKDVGHIFK Q3V0V3_MOUSE Q3V0V3_MOUSE -----------MNTIQQLMVILNSASDQPSENLISYFNNCTVNPKENILKRVKDVGHIFK Q9YGE5_ONCMY Q9YGE5_ONCMY LIPPQTPVRAAMNSIAQLRVDLITSGDQPSSNLAVYFKNCTVDPTEEVLQRVESLGLLFS Q8JG55_DANRE Q8JG55_DANRE ------------------------------------------------------------ A0JMQ4_DANRE A0JMQ4_DANRE IPVPQTPIRAAMTSIQQLRGDLTSGSDQPSSNLLVYYKNCTVDPSGEIKKRVEELGEVFI A8WGI9_DANRE A8WGI9_DANRE IPVPQTPIRAAMTSIQQLRGDLTSGSDQPSSNLLVYYKNCTVDPSGEIKKRVEELGEVFI Q4S8W2_TETNG Q4S8W2_TETNG LIPPQTPIRAAMTSIQQLRGDLTSSGDQPSTHLATYFKNCTVDPTQDVMKRLETLGEAFS Q98SK2_ORYLA Q98SK2_ORYLA LIPPQTPIRAAMNSIKMLRGDLPSSGDQPSSNLEIYFKNCTVDPTQGI-QSLEMLG-LFS Q1X7L8_LIMLI Q1X7L8_LIMLI LIPPQTPIRAAMTSIQQLRSDLFSTGDQPSTNLYSYFNNCTVDPTQDVLKRLKTLDQEFS A3DUJ4_XIPMA A3DUJ4_XIPMA MIPPQTPIRAAMTSIRMLRGDLPSNGDQPSTTLTTYFKNCTVDPTQDVQKRLETLGQVFS Q5J3Q9_FUNHE Q5J3Q9_FUNHE MIPPPTPIRAAMTSIQMLRGDLPSNGDRPSATLATYFKNCTVDPTQDVQKRLETLGQAFS MATCH CONSENSUS ???P?TP?R??M??I??L???L?S??DQPS??L??YF?NCTV?P?????KR????G??F?

Q98966_NOTVI Q98966_NOTVI QKFAEAVGQACEEIGYQRFKVGVRLAYRVMEAMLKSEEKRLSVQNFSNLLNNSAFHESLL RB_CHICK RB_CHICK KKFAEAVGQGCAEIGSQRYQLGVRLYYRVMESMLKSEEERLSVHNFSKLLNDNIFHTSLL B4DTN0_HUMAN B4DTN0_HUMAN EKFAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLL Q9BDQ3_PANTR Q9BDQ3_PANTR EKFAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLL Q59HH0_HUMAN Q59HH0_HUMAN EKFAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLL RB_HUMAN RB_HUMAN EKFAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLL B4DRB3_HUMAN B4DRB3_HUMAN EKFAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLL Q08E68_BOVIN Q08E68_BOVIN EKFAKAVGQGCMEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLL Q9N122_CANFA Q9N122_CANFA EKFAKAVGQGCMEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDDIFHMSLL RB_RAT RB_RAT EKFASAVGQGCIDIGAQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLL Q3UJG1_MOUSE Q3UJG1_MOUSE EKFANAVGQGCVDIGVQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLL RB_MOUSE RB_MOUSE EKFANAVGQGCVDIGVQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLL Q3URY9_MOUSE Q3URY9_MOUSE EKFANAVGQGCVDIGVQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLL Q4VA62_MOUSE Q4VA62_MOUSE EKFANAVGQGCVDIGVQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLL Q3V0V3_MOUSE Q3V0V3_MOUSE EKFANAVGQGCVDIGVQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLL Q9YGE5_ONCMY Q9YGE5_ONCMY QRFGQAVGPRCVGLGKQRFTLGIRLYYRVMESMLKSEEKRLSVQNFSKLLNDSTFHTSLL Q8JG55_DANRE Q8JG55_DANRE ------------------------------ESMLKSEEKRLSVQNFSKLLNNAAFHTSLL A0JMQ4_DANRE A0JMQ4_DANRE QRFAQAVGQHCEGLGRKRFYLGAQLYYKVMESMLKSEEKRLSVQNFSKLLNNAAFHTSLL A8WGI9_DANRE A8WGI9_DANRE QRFAQAVGQHCEGLGRKRFYLGAQLYYKVMESMLKSEEKRLSVQNFSKLLNNAAFHTSLL Q4S8W2_TETNG Q4S8W2_TETNG QRFGQAVGPHCVTLGRQRFNLGVKLYYKIMEAMLKSEEKRLSVQNFSKLLNDSTFHTSLL Q98SK2_ORYLA Q98SK2_ORYLA QKFGEAVGPHCIVYGRERFTLGVRLYYKVMEAMLESKKKRLFVQNFSKLLNDSTFHMSLL Q1X7L8_LIMLI Q1X7L8_LIMLI RSFGQAVGPRCIVLGKQRFILGVQLYYRVMEAMLKSEEKRLSVQNFSKLLNDSTFHTSLL A3DUJ4_XIPMA A3DUJ4_XIPMA QKFGEAVGPHCVVYGRQRFALGVRLYYKVMEAMLKSEEKRLSVQNFSKLLNDFTFHTSLL Q5J3Q9_FUNHE Q5J3Q9_FUNHE QKFGEAAGPHCVVYGQQRFGLAVRLYYKVMEAMLKSEEKRLSVQNFSKLLNDATFHTSLL MATCH *:**:*:::** ::***:***: ** *** CONSENSUS ??F??AVG??C???G?QR??LGV?LYY?VME?MLKSEE?RLS?QNFSKLLND??FH?SLL

Q98966_NOTVI Q98966_NOTVI ACSIEVVMATYGS---------------ISRETDLSFPWILEVFKIEPYDFYKVIESFIK RB_CHICK RB_CHICK ACALEIVMATYGRTASQSDG--------TSAETDLSFPWILNVFDLKAFDFYKVIESFIK B4DTN0_HUMAN B4DTN0_HUMAN ACALGVVMATYSRSTSQN----------LDSGTDLSFPWILNVLNLKAFDFYKVIESFIK Q9BDQ3_PANTR Q9BDQ3_PANTR ACALEVVMATYSRSTSQN----------LDSGTDLSFPWILNVLNLKAFDFYKVIESFIK Q59HH0_HUMAN Q59HH0_HUMAN ACALEVVMATYSRSTSQN----------LDSGTDLSFPWILNVLNLKAFDFYKVIESFIK RB_HUMAN RB_HUMAN ACALEVVMATYSRSTSQN----------LDSGTDLSFPWILNVLNLKAFDFYKVIESFIK B4DRB3_HUMAN B4DRB3_HUMAN ACALEVVMATYSRSTSQN----------LDSGTDLSFPWILNVLNLKAFDFYKVIESFIK Q08E68_BOVIN Q08E68_BOVIN ACALEVVMATYSRSMSQS----------LDTGTDLSFPWILNVFNLKAFDFYKVIESFIK Q9N122_CANFA Q9N122_CANFA ACALEVVMATYSRSTSQN----------LDTGTDLSFPWILNVLNLKAFDFYKVIESFIK RB_RAT RB_RAT ACALEVVMATYSRSMLQN----------LDSGTDLSFPWILNVLNLKAFDFYKVIESFIK Q3UJG1_MOUSE Q3UJG1_MOUSE ACALEVVMATYSRSTLQH----------LDSGTDLSFPWILNVLNLKAFDFYKVIESFIK RB_MOUSE RB_MOUSE ACALEVVMATYSRSTLQH----------LDSGTDLSFPWILNVLNLKAFDFYKVIESFIK Q3URY9_MOUSE Q3URY9_MOUSE ACALEVVMATYSRSTLQH----------LDSGTDLSFPWILNVLNLKAFDFYKVIESFIK Q4VA62_MOUSE Q4VA62_MOUSE ACALEVVMATYSRSTLQH----------LDSGTDLSFPWILNVLNLKAFDFYKVIESFIK Q3V0V3_MOUSE Q3V0V3_MOUSE ACALEVVMATYSRSTLQH----------LDSGTDLSFPWILNVLNLKAFDFYKVIESFIK Q9YGE5_ONCMY Q9YGE5_ONCMY ACALEVAMATYGGSTFKNGGY-SNGG--VPVETDLCFPWILDVFQLTAFDFYKVIESFIK Q8JG55_DANRE Q8JG55_DANRE ACALEVVIATYVGSSLKNGGFGRSSGASDSVESNLCFPWILSVFQLPAFDFYKVIESFIK A0JMQ4_DANRE A0JMQ4_DANRE ACALEVVIATYVGSSLKNGGFGRSSGASDSVESDLCFPWILSVFQLPAFDFYKVIESFIK A8WGI9_DANRE A8WGI9_DANRE ACALEVVIATYVGSSLKNGGFGRSSGASDSVESNLCFPWILSVFQLPAFDFYKVIESFIK Q4S8W2_TETNG Q4S8W2_TETNG ACALEVVMATYGESSFKTGGYNQGSG--DAAERNMCFPWILDVVNLAAFDFYKVIESFIK Q98SK2_ORYLA Q98SK2_ORYLA ACALEVVMVTYEESSFKNRGCSHGEG--DQAVRDLCFPWILDVFDLSAFDFYKVIESFIK Q1X7L8_LIMLI Q1X7L8_LIMLI ACALEVVMAAYGESGFKAGGYNHGGG--DSAGTDVCFPWILDVFNLAAFDFYKVIESFIK A3DUJ4_XIPMA A3DUJ4_XIPMA ACSLEVVMATYEESSFKNGGS-------DQTGTNLCFPWILNVLNLSAFDFYKVIESFIK Q5J3Q9_FUNHE Q5J3Q9_FUNHE ACSLEVVMATYEESSFKNGGG-------DQTGTNLCFPWILNVLNLSAFDFYKVIESFIK MATCH **:: :.:.:* ::.*****.*..: .:*********** CONSENSUS ACALEVVMATY??S????????????????????L?FPWIL?V??L?AFDFYKVIESFIK

Q98966_NOTVI Q98966_NOTVI DEPSLTREMIKHLESCEHRIMESLAWRSESPIYELIRQPREREGHVDQPEPTSSLNQPLE RB_CHICK RB_CHICK VEPSLTRDMIKHLERCEHRIMESLAWQSDSPLFDLIKQSKEREGQTDQPEPTSTLNLPLQ B4DTN0_HUMAN B4DTN0_HUMAN AEGNLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQ Q9BDQ3_PANTR Q9BDQ3_PANTR AEGNLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQ Q59HH0_HUMAN Q59HH0_HUMAN AEGNLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQ RB_HUMAN RB_HUMAN AEGNLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQ B4DRB3_HUMAN B4DRB3_HUMAN AEGNLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQ Q08E68_BOVIN Q08E68_BOVIN AEANLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQAKDREGPVDHFEPACTLNLPLQ Q9N122_CANFA Q9N122_CANFA AEANLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQAKDREGPADHLESACTLNLPLQ RB_RAT RB_RAT VEANLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDGEGP-DHLESACSLSLPLQ Q3UJG1_MOUSE Q3UJG1_MOUSE VEANLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDGEGP-DNLEPACPLSLPLQ RB_MOUSE RB_MOUSE VEANLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDGEGP-DNLEPACPLSLPLQ Q3URY9_MOUSE Q3URY9_MOUSE VEANLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDGEGP-DNLEPACPLSLPLQ Q4VA62_MOUSE Q4VA62_MOUSE VEANLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDGEGP-DNLEPACPLSLPLQ Q3V0V3_MOUSE Q3V0V3_MOUSE VEANLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDGEGP-DNLEPACPLSLPLQ Q9YGE5_ONCMY Q9YGE5_ONCMY AEPSLSKDIVKHLERCEHLIMETIAWREDSPLFELLKRTRE-EGPVEQAEPPATLNQPLQ Q8JG55_DANRE Q8JG55_DANRE AEPTLKHDMVKHLEQCEHVIMESLAWRADSPLFDLLKQSRE-EGPGEQAEPPATLNQPLH A0JMQ4_DANRE A0JMQ4_DANRE AEPTLKHDMVKHLEQCEHVIMESLAWRTDSPLFDLLKQSRE-EGPGEQAEPPATLNQPLH A8WGI9_DANRE A8WGI9_DANRE AEPTLKHDMVKHLEQCGHVIMESLAWRTDSPLFDLLKQSRE-EGPGEQAEPPATLNQPLH Q4S8W2_TETNG Q4S8W2_TETNG ADPTLSKDIVKHLETCENLIMERIAWRTVS---------------------LCPLT---- Q98SK2_ORYLA Q98SK2_ORYLA AEPTLSKDIIKHLETCENLIMEKIAWRTGSPLFELLKREHE-AGATEQAEPPASFSLPLQ Q1X7L8_LIMLI Q1X7L8_LIMLI AYPTLSKEIVKHLETCENLIMERIAWRTGSPLFELLKQEHD-SGAAEQVETPASFNQPLQ A3DUJ4_XIPMA A3DUJ4_XIPMA AEPTLSKDIIKHLETCENLIMERIAWRTGSPLFELLKQEHA-SAAAEPVETPASFSQPLQ Q5J3Q9_FUNHE Q5J3Q9_FUNHE AEPTLSKDIIKHLETCENLIMERIAWRTGSPLFELLQQEHA-SAAAEPVETTASFSQPLQ MATCH .*.::::**** * : *** :** * ..:. CONSENSUS ?E??L?????KHLE?CE??IME??AW???SPLF?L?KQ?????G?????E????L??PL?

Q98966_NOTVI Q98966_NOTVI HNHTAADLYLSPLRSPRR----NVPTSRAIPTLSVPESNNVPAPLPQPTQRSTSLSLFYK RB_CHICK RB_CHICK HNHTAADLYLSPVRSPKK----KASGHPQSGTSNPDAQPSATSQTQKP-QKSTSLSLFYK B4DTN0_HUMAN B4DTN0_HUMAN NNHTAADMYLSPVRSPKK----KGSTTRVNSTANAETQATSAFQTQKP-LKSTSLSLFYK Q9BDQ3_PANTR Q9BDQ3_PANTR NNHTAADMYLSPVRSPKK----KGSTTRVNSTANAETQATSAFQTQKP-LKSTSLSLFYK Q59HH0_HUMAN Q59HH0_HUMAN NNHTAADMYLSPVRSPKK----KGSTTRVNSTANAETQATSAFQTQKP-LKSTSLSLFYK RB_HUMAN RB_HUMAN NNHTAADMYLSPVRSPKK----KGSTTRVNSTANAETQATSAFQTQKP-LKSTSLSLFYK B4DRB3_HUMAN B4DRB3_HUMAN NNHTAADMYLSPVRSPKK----KGSTTRVNSTANAETQATSAFQTQKP-LKSTSLSLFYK Q08E68_BOVIN Q08E68_BOVIN NNHTAADMYLSPVRSPKK----KGPTPRVNSTPNSEAQATSAFQTQKP-LKSTSLSLFYK Q9N122_CANFA Q9N122_CANFA SNHTAADMYLSPVRSPKK----KGSTIRVNSTVNTEAQATSAFQTQKP-LKSTSLSLFYK RB_RAT RB_RAT SNHTAADMYLSPIRSPKK----RTSTTRVNSAANTETQAASAFHTQKP-LKSTSLSLFYK Q3UJG1_MOUSE Q3UJG1_MOUSE GNHTAADMYLSPLRSPKK----RTSTTRVNSAANTETQAASAFHTQKP-LKSTSLALFYK RB_MOUSE RB_MOUSE GNHTAADMYLSPLRSPKK----RTSTTRVNSAANTETQAASAFHTQKP-LKSTSLALFYK Q3URY9_MOUSE Q3URY9_MOUSE GNHTAADMYLSPLRSPKK----RTSTTRVNSAANTETQAASAFHTQKP-LKSTSLALFYK Q4VA62_MOUSE Q4VA62_MOUSE GNHTAADMYLSPLRSPKK----RTSTTRVNSAANTETQAASAFHTQKP-LKSTSLALFYK Q3V0V3_MOUSE Q3V0V3_MOUSE GNHTAADMYLSPLRSPKK----RTSTTRVNSAANTETQAASAFHTQKP-LKSTSLALFYK Q9YGE5_ONCMY Q9YGE5_ONCMY HNHTAADLYLSPVRPSSR----TLPAPESTAPPSSQPSAPAPHQTPRH-PKSNSLSLFYK Q8JG55_DANRE Q8JG55_DANRE HNHTAADLYLSPVRPCRQ--------PPV-------MEAEPPTPGTRA-PRSNSLSLFYK A0JMQ4_DANRE A0JMQ4_DANRE HNHTAADLYLSPVRPCRQ--------PPV-------MEAEPPTPGTRA-PRSNSLSLFYK A8WGI9_DANRE A8WGI9_DANRE HNHTAADLYLSPVRPCRQ--------PPV-------MEAEPPAPGTRA-PRSNSLSLFYK Q4S8W2_TETNG Q4S8W2_TETNG --------------------------------------------TQQP------------ Q98SK2_ORYLA Q98SK2_ORYLA HNHTAVDLYLSPIRPGLRVLPPESPATP-SSQASSQPTPQAAGQAPRQ-PKSNSLSLFYK Q1X7L8_LIMLI Q1X7L8_LIMLI HNHTAADLYLSPVRPGHRVLPPESPGT-VNSQASSHTPTQPPAQIPRH-PKSNSLSLFYK A3DUJ4_XIPMA A3DUJ4_XIPMA HSHTAADLYLTPTRPASRVLPPDSPATPPQQPTASQSTSQAPCQAPRQ-PKSNSLSLFYK Q5J3Q9_FUNHE Q5J3Q9_FUNHE HNHTAADLYLSPVRQGLRVLPSDSPATPPQQPTASQSSAQAPCQAPRQ-PKSNSLSLFYK MATCH : CONSENSUS ?NHTAAD?YLSP?R?????????????????????????????????????S?SL?LFYK

Q98966_NOTVI Q98966_NOTVI KVYRLAYLRMNTLCSKLLPDHPELEHVIWTLFQHTLQNEYELMKDRHLDQIMMCSMYAIC RB_CHICK RB_CHICK KVFRLAYLRLHTLFFRLLSEHPDLEPLIWTLFQHTLQNESELMRDRHLDQIMMCSMYGIC B4DTN0_HUMAN B4DTN0_HUMAN KVYRLAYLRLITLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGIC Q9BDQ3_PANTR Q9BDQ3_PANTR KVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGIC Q59HH0_HUMAN Q59HH0_HUMAN KVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGIC RB_HUMAN RB_HUMAN KVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGIC B4DRB3_HUMAN B4DRB3_HUMAN KVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGIC Q08E68_BOVIN Q08E68_BOVIN KVYRLAYLRLNTLCARFLSDHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGIC Q9N122_CANFA Q9N122_CANFA KEYRLAYLRLNTLCARLLSDHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGIC RB_RAT RB_RAT KVYRLAYLRLNTLCARLLSDHPEPEHIIWTLFQHTLENEYELMKDRHLDQIMMCSMYGIC Q3UJG1_MOUSE Q3UJG1_MOUSE KVYRLAYLRLNTLCARLLSDHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGIC RB_MOUSE RB_MOUSE KVYRLAYLRLNTLCARLLSDHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGIC Q3URY9_MOUSE Q3URY9_MOUSE KVYRLAYLRLNTLCARLLSDHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGIC Q4VA62_MOUSE Q4VA62_MOUSE KVYRLAYLRLNTLCARLLSDHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGIC Q3V0V3_MOUSE Q3V0V3_MOUSE KVYRLAYLRLNTLCARLLSDHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGIC Q9YGE5_ONCMY Q9YGE5_ONCMY KLYRLAYMRLKMLYTQLLTSHPELEPIMWTLFQHTLQNEYELMRDRHLDQLMMSAMYAIC Q8JG55_DANRE Q8JG55_DANRE KLYRMAYLRLKMLFSNLLTSHPEMEPIIWTLLQHTLQNEYELMRDRHLDQLIMSAMYAIC A0JMQ4_DANRE A0JMQ4_DANRE KLYRMAYLRLKMLFSNLLTSHPEMEPIIWTLLQHTLQNEYELMRDRHLDQLIMSAMYAIC A8WGI9_DANRE A8WGI9_DANRE KLYRMAYLRLKMLFSNLLTSHPEMEPIIWTPLQHTLQNEYELMRDRHLDQLIMSAMYAIC Q4S8W2_TETNG Q4S8W2_TETNG ------------------------------------------------------------ Q98SK2_ORYLA Q98SK2_ORYLA KLYRLAYTRLKTLCSCLLSNHPDLEHVIWTLFQHTLQYEYDLMRDRHLDQLMMSAMYAIC Q1X7L8_LIMLI Q1X7L8_LIMLI KLYRLAYTRLKILCSYLLSSHPELEPIMWTLFQHTLQHEYELMRDRHLDQLMMSAMYAIC A3DUJ4_XIPMA A3DUJ4_XIPMA KLYRLAYTRLKTLCSYLLSSHPELEPIIWTLFQYTLQHEYELMRDRHLDQLMMSAMYAIC Q5J3Q9_FUNHE Q5J3Q9_FUNHE KLYRLAYTRLKTLCSYLLSSHPELEPIIWTLFQYTLQHEYELMRDRHLDQLMMSAMYAIC MATCH CONSENSUS K?YRLAY?RL??L???LL??HPE?E?IIWTLFQHTLQ?EYELMRDRHLDQ?MM??MY?IC

Q98966_NOTVI Q98966_NOTVI KVKAIDLRFKTIVTAYKELPNTNQETFKHVLIRDGQHDSIIVFYNLVFMQKLKTNILQYA RB_CHICK RB_CHICK KVKNVDLRFKTIVSAYKELPNTNQETFKRVLIREEQYDSIIVFYNLVFMQKLKTNILQYA B4DTN0_HUMAN B4DTN0_HUMAN KVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYA Q9BDQ3_PANTR Q9BDQ3_PANTR KVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYA Q59HH0_HUMAN Q59HH0_HUMAN KVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYA RB_HUMAN RB_HUMAN KVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYA B4DRB3_HUMAN B4DRB3_HUMAN KVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYA Q08E68_BOVIN Q08E68_BOVIN KVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIREEEYDSIIVFYNSVFMQRLKTNILQYA Q9N122_CANFA Q9N122_CANFA KVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIREEEYDSIIVFYNSVFMQRLKTNILQYA RB_RAT RB_RAT KVKNIDLKFKIIVTAYKDLPHAAQETFKRVLIREEEFDSIIVFYNSVFMQRLKTNILQYA Q3UJG1_MOUSE Q3UJG1_MOUSE KVKNIDLKFKIIVTAYKDLPHAAQETFKRVLTREEEFDSIIVFYNSVFMQRLKTNILQYA RB_MOUSE RB_MOUSE KVKNIDLKFKIIVTAYKDLPHAAQETFKRVLIREEEFDSIIVFYNSVFMQRLKTNILQYA Q3URY9_MOUSE Q3URY9_MOUSE KVKNIDLKFKIIVTAYKDLPHAAQETFKRVLIREEEFDSIIVFYNSVFMQRLKTNILQYA Q4VA62_MOUSE Q4VA62_MOUSE KVKNIDLKFKIIVTAYKDLPHAAQETFKRVLIREEEFDSIIVFYNSVFMQRLKTNILQYA Q3V0V3_MOUSE Q3V0V3_MOUSE KVKNIDLKFKIIVTAYKDLPHAAQETFKRVLIREEEFDSIIVFYNSVFMQRLKTNILQYA Q9YGE5_ONCMY Q9YGE5_ONCMY KVKNVDLRFKTIVTAYKNMPNTNQETFKHVLIREGQYDSIIVFYNLVFMQKLKTNILQYA Q8JG55_DANRE Q8JG55_DANRE KVKNVDLRFKTIVTAYKELPNTNQETFKRVLIREGQYDSINVFYNLVFMQKLKTNSLQYS A0JMQ4_DANRE A0JMQ4_DANRE KVKNVDLRFKTIVTAYKELPNTNQETFKRVLIREGQYDSIIVFYNLVFMQKLKTNILQYS A8WGI9_DANRE A8WGI9_DANRE KVKNVDLRFKTIVTAYKELPNTNQETFKRVLIREGQYDSIIVFYNLVFMQKLKTNILQYS Q4S8W2_TETNG Q4S8W2_TETNG ------------------------------------------------------------ Q98SK2_ORYLA Q98SK2_ORYLA KVKSVDLRFKLIVSAYKNMPNTSQETFKHVLITEGQYDSIIVFYNQVFMQKLKTNILQYA Q1X7L8_LIMLI Q1X7L8_LIMLI KVKSVDLRFKTIVTAYKNLPNTNQETFKHVLITEGHYDSIIIFYNQVFMQRLKTNILQYA A3DUJ4_XIPMA A3DUJ4_XIPMA KVKSVDLRFKSIVSAYKNMTNTNQETFKNVLIIEGHYDSIIVFYNQVFMQKLKTNILQHA Q5J3Q9_FUNHE Q5J3Q9_FUNHE KVKSVDLRFKSIVSAYKNMANTNQETFKNVLITEGHYDSIIVFYNQVFMQKLKTNILQHA MATCH CONSENSUS KVK??DL?FK?IV?AYK??P???QETFK?VLI?E???DSIIVFYN?VFMQ?LKTNILQYA

Q98966_NOTVI Q98966_NOTVI TLRNPTLSPIPHIPRSPYKISNSPLRLPGGNNIYISPLKSPYKHPEGLLSPTKMTPRSRI RB_CHICK RB_CHICK SNRPPTLSPIPHIPRSPYQFSNSPRRVPAGNNIYISPLKSPYKFSDGFHSPTKMTPRSRI B4DTN0_HUMAN B4DTN0_HUMAN STRPPTLSPIPHIPRSPYKFPSSPLRIPGG-NIYISPLKSPYKISEGLPTPTKMTPRSRI Q9BDQ3_PANTR Q9BDQ3_PANTR STRPPTLSPIPHIPRSPYKFPSSPLRIPGG-NIYISPLKSPYKISEGLPTPTKMTPRSRI Q59HH0_HUMAN Q59HH0_HUMAN STRPPTLSPIPHIPRSPYKFPSSPLRIPGG-NIYISPLKSPYKISEGLPTPTKMTPRSRI RB_HUMAN RB_HUMAN STRPPTLSPIPHIPRSPYKFPSSPLRIPGG-NIYISPLKSPYKISEGLPTPTKMTPRSRI B4DRB3_HUMAN B4DRB3_HUMAN STRPPTLSPIPHIPRSPYKFPSSPLRIPGG-NIYISPLKSPYKISEGLPTPTKMTPRSRI Q08E68_BOVIN Q08E68_BOVIN STRPPTLSPIPHIPRSPYKFSSSPLRIPGG-NIYISPLNNPYKISEGLPTPTKMTPRSRI Q9N122_CANFA Q9N122_CANFA STRPPTLSPIPHIPRSPYKFSSSPLRIPGG-NIYISPLKNPYKISEGVPTPTKMTPRSRI RB_RAT RB_RAT STRPPTLSPIPHIPRSPYKFSSSPLRIPGG-NIYMSPLKSPYKISEGLPTPTKMTPRSRI Q3UJG1_MOUSE Q3UJG1_MOUSE STRPPTLSPIPHIPRSPYKFSSSPLRIPGG-NIYISPIKSPYKISEGLPTPTKMTPRSRI RB_MOUSE RB_MOUSE STRPPTLSPIPHIPRSPYKFSSSPLRIPGG-NIYISPLKSPYKISEGLPTPTKMTPRSRI Q3URY9_MOUSE Q3URY9_MOUSE STRPPTLSPIPHIPRSPYKFSSSPLRIPGG-NIYISPLKSPYKISEGLPTPTKMTPRSRI Q4VA62_MOUSE Q4VA62_MOUSE STRPPTLSPIPHIPRSPYKFSSSPLRIPGG-NIYISPLKSPYKISEGLPTPTKMTPRSRI Q3V0V3_MOUSE Q3V0V3_MOUSE STRPPTLSPIPHIPRSPYKFSSSPLRIPGG-NIYISPLKSPYKISEGLPTPTKMTPRSRI Q9YGE5_ONCMY Q9YGE5_ONCMY SPRPPTLSPIPHIPRSPYKFPNSPLRVPGSNNVYISPMKSPTR------MSPVMTPRTRI Q8JG55_DANRE Q8JG55_DANRE S----------------------------------------------------------- A0JMQ4_DANRE A0JMQ4_DANRE SPRPPPLSPIPHIPCSPYK--NSPLRVPGSNNVYVSPLKSSRV------SPLVMTPRSRI A8WGI9_DANRE A8WGI9_DANRE SPRPPPLSPIPHIPCSPYK--NSPLRVPGSNNVYVSPLKSSRV------SPLVMTPRSRI Q4S8W2_TETNG Q4S8W2_TETNG ------------------------------------------------------------ Q98SK2_ORYLA Q98SK2_ORYLA STRPPTLSPIPQIPCSPYKFPNSPLRVPGSNNVYISPLKNSRL------SAGMMAPRSRM Q1X7L8_LIMLI Q1X7L8_LIMLI STRPPTLSPIPQIPRSPYKILNSPLRVPGSNNVYISPLKNPRN------SPSIMTPRSRM A3DUJ4_XIPMA A3DUJ4_XIPMA SIRPPPLSPIPQIPRSPYKLPNSPLRVPGSNNIYISPLRSSRM------SPGIMTPRSRM Q5J3Q9_FUNHE Q5J3Q9_FUNHE STKPPPPSPIPQMPRSPYKFPNSPLRVPGSNNVYISPLKNSRM------SPGIMTPRSRM MATCH CONSENSUS S?RPP?LSPIP?IP?SPYK???SPLR?PG??N?Y?SPLK???????????P??MTPRSR?

Q98966_NOTVI Q98966_NOTVI LVSIGEQFGTAEKFQKINQMLSSSERLRKRAAESSNAPKPLKRLHFDTDGPDETDGSKH- RB_CHICK RB_CHICK LVSIGETFGTSEKFQKINQMVCNSESHVKRSAEPSDAPKPLKRLRFDIEGQDEADGGKHL B4DTN0_HUMAN B4DTN0_HUMAN LVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHL Q9BDQ3_PANTR Q9BDQ3_PANTR LVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHL Q59HH0_HUMAN Q59HH0_HUMAN LVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHL RB_HUMAN RB_HUMAN LVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHL B4DRB3_HUMAN B4DRB3_HUMAN LVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHL Q08E68_BOVIN Q08E68_BOVIN LVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHL Q9N122_CANFA Q9N122_CANFA LVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGTDEADGSKHL RB_RAT RB_RAT LVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGGNPPKPLKKLRFDIEGSDEADGSKHL Q3UJG1_MOUSE Q3UJG1_MOUSE LVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGGNPPKPLKKLRFDIEGADEADGSKHL RB_MOUSE RB_MOUSE LVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGGNPPKPLKNVRFDIEGADEADGSKHL Q3URY9_MOUSE Q3URY9_MOUSE LVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGGNPPKPLKKLRFDIEGADEADGSKHL Q4VA62_MOUSE Q4VA62_MOUSE LVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGGNPPKPLKKLRFDIEGADEADGSKHL Q3V0V3_MOUSE Q3V0V3_MOUSE LVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGGNPPKPLKKLRFDIEGADEADGSKHL Q9YGE5_ONCMY Q9YGE5_ONCMY LVSIGESFGTSDKFQKINAMVNSSDRSLKRSLDMSSAPKPLKRLRFDVEGQDESDESKP- Q8JG55_DANRE Q8JG55_DANRE ------------------------------------------------------------ A0JMQ4_DANRE A0JMQ4_DANRE LISIGESFGSADKFQKINQMLSSSDWSLKRSLDGGSAPKPLKRLRFDMDGQDEADGSKS- A8WGI9_DANRE A8WGI9_DANRE LISIGESFGSADKFQKINQMVSSSDWSLKRSLDGGSAPKPLKRLRFDMDGQDEADGSKS- Q4S8W2_TETNG Q4S8W2_TETNG -----------------------------------------------LQG---------- Q98SK2_ORYLA Q98SK2_ORYLA LVSIGESFGFANRFQKINQMVNSGDRAHKRTLDGGSALKPLKRLRFDVDGQDEADGSKS- Q1X7L8_LIMLI Q1X7L8_LIMLI LVSIGESFGLSSRFQKINQMVNSSDRSFKRTLDLGSAPKPLKRLRFDVDGQDEADGSKS- A3DUJ4_XIPMA A3DUJ4_XIPMA LVSIGESFGLGNRFQKINQMV-NSERSHKRTMDQSAAIKPLKKLRFDVDGQDEADGSKP- Q5J3Q9_FUNHE Q5J3Q9_FUNHE LVSIGESFGLSNRFQKINQMVNSSERSHKRTMDSGSTLKPLKRLRFDMDGQDEADGSKP- MATCH CONSENSUS LVSIGESFG????FQKINQMV??S????KR????????KPLK?LRFD??G?DEADGSK??

Q98966_NOTVI Q98966_NOTVI -----LAQKLAEMTSTRSRMQKQKQDEEMDTTLKEEK RB_CHICK RB_CHICK PQESKFQQKLAEMTSTRTRMQKQKLNDGNDTSANEEK B4DTN0_HUMAN B4DTN0_HUMAN PGESKFQQKLAEMTSTRTRMQKQKMNDSMDTSNKEEK Q9BDQ3_PANTR Q9BDQ3_PANTR PGESKFQQKLAEMTSTRTRMQKQKMNDSMDTSNKEEK Q59HH0_HUMAN Q59HH0_HUMAN PGESKFQQKLAEMTSTRTRMQKQKMNDSMDTSNKEEK RB_HUMAN RB_HUMAN PGESKFQQKLAEMTSTRTRMQKQKMNDSMDTSNKEEK B4DRB3_HUMAN B4DRB3_HUMAN PGESKFQQKLAEMTSTRTRMQKQKMNDSMDTSNKEEK Q08E68_BOVIN Q08E68_BOVIN PGESKFQQKLAEMTSTRTRMQKQKMNESVDTSNREEK Q9N122_CANFA Q9N122_CANFA PGESKFQQKL--------------------------- RB_RAT RB_RAT PAESKFQQKLAEMTSTRTRMQKQKLNDSMEISNKEEK Q3UJG1_MOUSE Q3UJG1_MOUSE PAESKFQQKLAEMTSTRTRMQKQRMNESKDVSNKEEK RB_MOUSE RB_MOUSE PAESKFQQKLAEMTSTRTRMQKQRMNESKDVSNKEEK Q3URY9_MOUSE Q3URY9_MOUSE PAESKFQQKLAEMTSTRTRMQKQRMNESKDVSNKEEK Q4VA62_MOUSE Q4VA62_MOUSE PAESKFQQKLAEMTSTRTRMQKQRMNESKDVSNKEEK Q3V0V3_MOUSE Q3V0V3_MOUSE PAESKFQQKLAEMTSTRTRMQKQRMNESKDVSNKEEK Q9YGE5_ONCMY Q9YGE5_ONCMY GEESRLIQKLAEIGSTRTRMQEQKMKDDAESEKDKP- Q8JG55_DANRE Q8JG55_DANRE ------------------------------------- A0JMQ4_DANRE A0JMQ4_DANRE SGESALIQKLAEMSSTRSRMQEQKLKEESDKDHPEP- A8WGI9_DANRE A8WGI9_DANRE SGESALIQKLAEMSSTRSRMQEQKLKEESDKDHPEP- Q4S8W2_TETNG Q4S8W2_TETNG ------------------------------------- Q98SK2_ORYLA Q98SK2_ORYLA GGESALIQKLAEMSSTRSRMQEQKMKEDAESRKKT-- Q1X7L8_LIMLI Q1X7L8_LIMLI GGDSTLIQKLAEMSSARSRMQEQKMK----------- A3DUJ4_XIPMA A3DUJ4_XIPMA GGDSTLIQKLTEMSSTWSRMHEQKMKEEPETRDEPQ- Q5J3Q9_FUNHE Q5J3Q9_FUNHE GGDSTLIQKLTEMSSTWNRIHEQKMKEDPDTREEPQ- MATCH CONSENSUS ???S???QKL?EM?ST??RM??Q??????????????


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