Alignment of the gene Family HBG017831 of HOVERGEN

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Isoforms are ON
Q4T188_TETNG Q4T188_TETNG -----------------------------MQAAPLQYDF-FSEENAPKWRGLLVPSLEKV Q497A5_RAT Q497A5_RAT ------------------------------------------------------------ Q3USK4_MOUSE Q3USK4_MOUSE -----------------------------MQAQQLPYEF-FSEENAPKWRGLLVPALKKV Q2M4G6_MOUSE Q2M4G6_MOUSE ------------------------------------------------------------ SOS1_MOUSE SOS1_MOUSE -----------------------------MQAQQLPYEF-FSEENAPKWRGLLVPALKKV Q8NIA3_HUMAN Q8NIA3_HUMAN -----------------------------MQAQQLPYEF-FSEENAPKWRGLLVPALKKV Q53SF8_HUMAN Q53SF8_HUMAN -----------------------------------------------------------V SOS1_HUMAN SOS1_HUMAN -----------------------------MQAQQLPYEF-FSEENAPKWRGLLVPALKKV Q59GG9_HUMAN Q59GG9_HUMAN ------------------------------------------------------------ SOS2_MOUSE SOS2_MOUSE -----------------------------MQQAPQPYEF-FSEENSPKWRGLLVPALRKV Q59G32_HUMAN Q59G32_HUMAN RGEAARALPVRPPARPAGCPRCGGAVAGAMQQAPQPYEF-FSEENSPKWRGLLVSALRKV B7ZKT5_HUMAN B7ZKT5_HUMAN -----------------------------MQQAPQPYEF-FSEENSPKWRGLLVSALRKV B7ZKT6_HUMAN B7ZKT6_HUMAN -----------------------------MQQAPQPYEF-FSEENSPKWRGLLVSALRKV SOS2_HUMAN SOS2_HUMAN -----------------------------MQQAPQPYEF-FSEENSPKWRGLLVSALRKV B8A6E4_DANRE B8A6E4_DANRE -----------------------------MQ-----HDFSSSEENSARWRGLFVQGLRKV Q4REE9_TETNG Q4REE9_TETNG -----------------------------MQPQQI-YDF-SSDENSHKWRGLFVQALRKV MATCH CONSENSUS ???????????????????????????????????????????????????????????V

Q4T188_TETNG Q4T188_TETNG LNQVHPKLVSQQEALQYIEELILLLLSMLCQAQPRSVQDVEDRVQKSFPHPIDKWAIADA Q497A5_RAT Q497A5_RAT ------------------------------------------------------------ Q3USK4_MOUSE Q3USK4_MOUSE QGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADA Q2M4G6_MOUSE Q2M4G6_MOUSE ------------------------------------------------------------ SOS1_MOUSE SOS1_MOUSE QGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADA Q8NIA3_HUMAN Q8NIA3_HUMAN QGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADA Q53SF8_HUMAN Q53SF8_HUMAN QGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADA SOS1_HUMAN SOS1_HUMAN QGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADA Q59GG9_HUMAN Q59GG9_HUMAN ------------------------------------------------------------ SOS2_MOUSE SOS2_MOUSE QEQVHPTLSANEESLYYIEELIFQLLNKLCMAQPRTVQDVEERVQKTFPHPIDKWAIADA Q59G32_HUMAN Q59G32_HUMAN QEQVHPTLSANEESLYYIEELIFQLLNKLCMAQPRTVQDVEERVQKTFPHPIDKWAIADA B7ZKT5_HUMAN B7ZKT5_HUMAN QEQVHPTLSANEESLYYIEELIFQLLNKLCMAQPRTVQDVEERVQKTFPHPIDKWAIADA B7ZKT6_HUMAN B7ZKT6_HUMAN QEQVHPTLSANEESLYYIEELIFQLLNKLCMAQPRTVQDVEERVQKTFPHPIDKWAIADA SOS2_HUMAN SOS2_HUMAN QEQVHPTLSANEESLYYIEELIFQLLNKLCMAQPRTVQDVEERVQKTFPHPIDKWAIADA B8A6E4_DANRE B8A6E4_DANRE QVQVHPNLSAKEDALQHIEALILQLLNKLCVTQPRTIADVEDRVQKTFPNPIDKWAMGDA Q4REE9_TETNG Q4REE9_TETNG QKQVHPGLLAKEDALQHIEELILQLLNMLCMAQPRSVQDVEERVQKTFPHPIDKWAIADA MATCH CONSENSUS ??QVHP?L??????L???E?LI??LL??LC??QPR???DVE?RVQK?FP?PIDKWA??DA

Q4T188_TETNG Q4T188_TETNG QAAIEKRKRRNPLALPVEKIHPLLKVCTLLHYGPHTP---------IYATYSSDACHCQE Q497A5_RAT Q497A5_RAT ------------------------------------------------------------ Q3USK4_MOUSE Q3USK4_MOUSE QSAIEKRKRRNPLSLPAERIHHLLR----------------------------------E Q2M4G6_MOUSE Q2M4G6_MOUSE ------------------------------------------------------------ SOS1_MOUSE SOS1_MOUSE QSAIEKRKRRNPLSLPAERIHHLLR----------------------------------E Q8NIA3_HUMAN Q8NIA3_HUMAN QSAIEKRKRRNPLSLPVEKIHPLLK----------------------------------E Q53SF8_HUMAN Q53SF8_HUMAN QSAIEKRKRRNPLSLPVEKIHPLLK----------------------------------E SOS1_HUMAN SOS1_HUMAN QSAIEKRKRRNPLSLPVEKIHPLLK----------------------------------E Q59GG9_HUMAN Q59GG9_HUMAN ------------------------------------------------------------ SOS2_MOUSE SOS2_MOUSE QSAIEKRKRRNPLLLPVDKIHPSLK----------------------------------E Q59G32_HUMAN Q59G32_HUMAN QSAIEKRKRRNPLLLPVDKIHPSLK----------------------------------E B7ZKT5_HUMAN B7ZKT5_HUMAN QSAIEKRKRRNPLLLPVDKIHPSLK----------------------------------E B7ZKT6_HUMAN B7ZKT6_HUMAN QSAIEKRKRRNPLLLPVDKIHPSLK----------------------------------E SOS2_HUMAN SOS2_HUMAN QSAIEKRKRRNPLLLPVDKIHPSLK----------------------------------E B8A6E4_DANRE B8A6E4_DANRE QNAIEKRKRRNPLLLPVDKIHPLLK----------------------------------E Q4REE9_TETNG Q4REE9_TETNG QAAIEKRKRRNPLLLPVDKIHPLLKVPLGHPSRRRSEGKRRIVFSDTGAGTLRSGPLPQE MATCH CONSENSUS Q?AIEKRKRRNPL?LP???IH??L???????????????????????????????????E

Q4T188_TETNG Q4T188_TETNG VLGYKIDHQVSLYMVAVLEYISADILKLAGNYVKNIRHCEISQQDITVAMCADKVLMDMF Q497A5_RAT Q497A5_RAT ------------------------------------------------------------ Q3USK4_MOUSE Q3USK4_MOUSE VLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMF Q2M4G6_MOUSE Q2M4G6_MOUSE -----------------------------GNYVRNIRHYEITKQDIKVAMCADKVLMDMF SOS1_MOUSE SOS1_MOUSE VLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMF Q8NIA3_HUMAN Q8NIA3_HUMAN VLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMF Q53SF8_HUMAN Q53SF8_HUMAN VLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMF SOS1_HUMAN SOS1_HUMAN VLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMF Q59GG9_HUMAN Q59GG9_HUMAN ------------------------------------------------------------ SOS2_MOUSE SOS2_MOUSE VLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMF Q59G32_HUMAN Q59G32_HUMAN VLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMF B7ZKT5_HUMAN B7ZKT5_HUMAN VLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMF B7ZKT6_HUMAN B7ZKT6_HUMAN VLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMF SOS2_HUMAN SOS2_HUMAN VLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMF B8A6E4_DANRE B8A6E4_DANRE VLGYKIDYNVCLYIVAVLEYISADILKLAGNYVSNIRHYEISQQDITVSMCADKVLMDMF Q4REE9_TETNG Q4REE9_TETNG VLGYKVDYHVSLYIVAVLEYISADILKLAGNYVGNIRHYEISQQDIKVSMCADKVLMDMF MATCH CONSENSUS VLGYK?D??V??Y?VAVLEYISADILKL?GNYV?NIRHYEI??QDI?V?MCADKVLMDMF

Q4T188_TETNG Q4T188_TETNG HQDEDVISGFPLMDEEPLANEEQSYYELVRSFMSDGRLYLRQLNLLILVFREPFASSPML Q497A5_RAT Q497A5_RAT ------------------------------------------------------------ Q3USK4_MOUSE Q3USK4_MOUSE HQDVEDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKL Q2M4G6_MOUSE Q2M4G6_MOUSE HQDVEDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKL SOS1_MOUSE SOS1_MOUSE HQDVEDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKL Q8NIA3_HUMAN Q8NIA3_HUMAN HQDVEDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKL Q53SF8_HUMAN Q53SF8_HUMAN HQDVEDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKL SOS1_HUMAN SOS1_HUMAN HQDVEDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKL Q59GG9_HUMAN Q59GG9_HUMAN ------------------------------------------------------------ SOS2_MOUSE SOS2_MOUSE DQD-DDIGLVSLCEDEPCSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLLDRKL Q59G32_HUMAN Q59G32_HUMAN DQD--DIGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKL B7ZKT5_HUMAN B7ZKT5_HUMAN DQD--DIGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKL B7ZKT6_HUMAN B7ZKT6_HUMAN DQD--DIGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKL SOS2_HUMAN SOS2_HUMAN DQD--DIGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKL B8A6E4_DANRE B8A6E4_DANRE DQE-EEMGLLSQSVEEVSSSGVLTYDDLVRLEIAEERQYLRELDLIIKVFRQAFMSNSKL Q4REE9_TETNG Q4REE9_TETNG DQE-EDIGLMSQCTEEPSSSGELAYDDLVRLELAEERQYLRELDLIIKVFRHHFLSNPKI MATCH CONSENSUS ?Q????I???S????EP??SGE??Y?DLV????AE?RQY?REL??IIKVFR??F?S??KL

Q4T188_TETNG Q4T188_TETNG FSHHDVDSIFSRIVDIHEVTVKLLGLIEDSVEMTDEDSPHPLVGSCFEDLAEELAFDPYE Q497A5_RAT Q497A5_RAT ------------------------------------------------------------ Q3USK4_MOUSE Q3USK4_MOUSE FSSNDVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYE Q2M4G6_MOUSE Q2M4G6_MOUSE FSSNDVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYE SOS1_MOUSE SOS1_MOUSE FSSNDVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYE Q8NIA3_HUMAN Q8NIA3_HUMAN FSANDVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYE Q53SF8_HUMAN Q53SF8_HUMAN FSANDVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYE SOS1_HUMAN SOS1_HUMAN FSANDVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYE Q59GG9_HUMAN Q59GG9_HUMAN ------------------------------------------------------------ SOS2_MOUSE SOS2_MOUSE FKPSEIEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYE Q59G32_HUMAN Q59G32_HUMAN FKPSDIEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYE B7ZKT5_HUMAN B7ZKT5_HUMAN FKPSDIEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYE B7ZKT6_HUMAN B7ZKT6_HUMAN FKPSDIEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYE SOS2_HUMAN SOS2_HUMAN FKPSDIEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYE B8A6E4_DANRE B8A6E4_DANRE FSAQDVELAFSNILEVQELTVKLLGLIEDAVEMTADGSPHPLVGSCFEDLAEEQAFDPYE Q4REE9_TETNG Q4REE9_TETNG FTPQDVEVIFSNILDIHELTVKLLGLIEDAVEMTADGSPHPLVGSCFEDLAEEQAFDPYE MATCH CONSENSUS F???D?E?IFS?I?DIHEL?VKLLG?IED?VEMT???SPHPL?GSCFEDLAEE?AFDPYE

Q4T188_TETNG Q4T188_TETNG TYTQDILRSGFHEHFLSQVSKPGAAFHLQSTPISTSVWMRMMRAACSITSVSLCLQSICE Q497A5_RAT Q497A5_RAT -------------AFSQSAIKPGAALY---------------------------LQSIGE Q3USK4_MOUSE Q3USK4_MOUSE SYARDILRPGFHGHFLSQLSKPGAALY---------------------------LQSIGE Q2M4G6_MOUSE Q2M4G6_MOUSE SYARDILRPGFHGHFLSQLSKPGAALY---------------------------LQSIGE SOS1_MOUSE SOS1_MOUSE SYARDILRPGFHGHFLSQLSKPGAALY---------------------------LQSIGE Q8NIA3_HUMAN Q8NIA3_HUMAN SYARDILRPGFHDRFLSQLSKPGAALY---------------------------LQSIGE Q53SF8_HUMAN Q53SF8_HUMAN SYARDILRPGFHDRFLSQLSKPGAALY---------------------------LQSIGE SOS1_HUMAN SOS1_HUMAN SYARDILRPGFHDRFLSQLSKPGAALY---------------------------LQSIGE Q59GG9_HUMAN Q59GG9_HUMAN ------------------------------------------------------------ SOS2_MOUSE SOS2_MOUSE TLSQDILAPEFNDHFSKLMARPAVALH---------------------------FQSIAD Q59G32_HUMAN Q59G32_HUMAN TLSQDILSPEFHEHFNKLMARPAVALH---------------------------FQSIAD B7ZKT5_HUMAN B7ZKT5_HUMAN TLSQDILSPEFHEHFNKLMARPAVALH---------------------------FQSIAD B7ZKT6_HUMAN B7ZKT6_HUMAN TLSQDILSPEFHEHFNKLMARPAVALH---------------------------FQ---- SOS2_HUMAN SOS2_HUMAN TLSQDILSPEFHEHFNKLMARPAVALH---------------------------FQSIAD B8A6E4_DANRE B8A6E4_DANRE TLSQDILSKEFCQHFNTLMSRPTVALH---------------------------FQSIAE Q4REE9_TETNG Q4REE9_TETNG TMSQDILSKDFHEHFNNLMARPTAGLY---------------------------FQSVAE MATCH CONSENSUS ????DIL???F???F??????P??AL?????????????????????????????QSI??

Q4T188_TETNG Q4T188_TETNG GFKEAVQYVLPRLLLTPVYHCLHMFETLKQLEEKSQDEEDKECMKQAITALLNLQSSMER Q497A5_RAT Q497A5_RAT GFKEAVQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDKECMKQAITALLNVQSGMEK Q3USK4_MOUSE Q3USK4_MOUSE GFKEAVQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDKECMKQAITALLNVQSGMEK Q2M4G6_MOUSE Q2M4G6_MOUSE GFKEAVQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDKECMKQAITALLNVQSGMEK SOS1_MOUSE SOS1_MOUSE GFKEAVQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDKECMKQAITALLNVQSGMEK Q8NIA3_HUMAN Q8NIA3_HUMAN GFKEAVQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDKECLKQAITALLNVQSGMEK Q53SF8_HUMAN Q53SF8_HUMAN GFKEAVQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDKECLKQAITALLNVQSGMEK SOS1_HUMAN SOS1_HUMAN GFKEAVQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDKECLKQAITALLNVQSGMEK Q59GG9_HUMAN Q59GG9_HUMAN -FKEAVQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDKECLKQAITALLNVQSGMEK SOS2_MOUSE SOS2_MOUSE GFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDKECLNQAITALMNLQGSMDR Q59G32_HUMAN Q59G32_HUMAN GFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAITALMNLQGSMDR B7ZKT5_HUMAN B7ZKT5_HUMAN GFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAITALMNLQGSMDR B7ZKT6_HUMAN B7ZKT6_HUMAN -----------------------------QLKACSEEQEDRECLNQAITALMNLQGSMDR SOS2_HUMAN SOS2_HUMAN GFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAITALMNLQGSMDR B8A6E4_DANRE B8A6E4_DANRE GFKEAVQYVLPQLMMVPVYHCIHYFELLQQLQECSEEQDDRECLKQAQTALINLQCSIER Q4REE9_TETNG Q4REE9_TETNG GFKEAVQYVLPQLMMVPVYHCMHYFELLQQLQERSEDQDDRECLKQAITALLNLQCSVER MATCH **: *::::*:**::** ***:*:* .::: CONSENSUS GFKEAV?YVLPRL?L?PVYHC?HYFELLKQL???SE?QED?EC??QAITAL?N?Q??M??

Q4T188_TETNG Q4T188_TETNG TCSRSLAKRRLSESACRFYSHQMKGKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGT Q497A5_RAT Q497A5_RAT ICSKNLAKRRLSESACRFYSQQMKGKQLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGT Q3USK4_MOUSE Q3USK4_MOUSE ICSKSLAKRRLSESACRFYSQQMKGKQLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGT Q2M4G6_MOUSE Q2M4G6_MOUSE ICSKSLAKRRLSESACRFYSQQMKGKQLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGT SOS1_MOUSE SOS1_MOUSE ICSKSLAKRRLSESACRFYSQQMKGKQLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGT Q8NIA3_HUMAN Q8NIA3_HUMAN ICSKSLAKRRLSESACRFYSQQMKGKQLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGT Q53SF8_HUMAN Q53SF8_HUMAN ICSKSLAKRRLSESACRFYSQQMKGKQLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGT SOS1_HUMAN SOS1_HUMAN ICSKSLAKRRLSESACRFYSQQMKGKQLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGT Q59GG9_HUMAN Q59GG9_HUMAN ICSKSLAKRRLSESACRFYSQQMKGKQLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGT SOS2_MOUSE SOS2_MOUSE IYKQHSPRRRPGDPVCLFYNRQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGP Q59G32_HUMAN Q59G32_HUMAN IYKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGP B7ZKT5_HUMAN B7ZKT5_HUMAN ICKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGP B7ZKT6_HUMAN B7ZKT6_HUMAN IYKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGP SOS2_HUMAN SOS2_HUMAN IYKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGP B8A6E4_DANRE B8A6E4_DANRE IYAKHQPRRKQGEPLYRLYSRASRSKQAAIKRMNDIQKSIDGWEGKDIGQCCSQFILEGA Q4REE9_TETNG Q4REE9_TETNG IYTKHQPRRKPGEPMYRLYSRQVRSKQLAIKRMNEIQKSIDGWEGKDIGQCCSEFILEGP MATCH : .:*: .:. :*.: :.*: ***:**:***.*************.:**:**. CONSENSUS I???????RR?????C?FYS?Q???K?LAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEG?

Q4T188_TETNG Q4T188_TETNG LTRVGAKHERHIFLFDGLMICCKLNHGPPRLPGASSTAEYRLKEKFFMRKVQINDKDDKE Q497A5_RAT Q497A5_RAT LTRVGAKHERHIFLFDGLMICCKSNHGQPRLPGASN-AEYRLKEKFFMRKVQINDKDDT- Q3USK4_MOUSE Q3USK4_MOUSE LTRVGAKHERHIFLFDGLMICCKSNHGQPRLPGASS-AEYRLKEKFFMRKVQINDKDDT- Q2M4G6_MOUSE Q2M4G6_MOUSE LTRVGAKHERHIFLFDGLMICCKSNHGQPRLPGASS-AEYRLKEKFFMRKVQINDKDDT- SOS1_MOUSE SOS1_MOUSE LTRVGAKHERHIFLFDGLMICCKSNHGQPRLPGASS-AEYRLKEKFFMRKVQINDKDDT- Q8NIA3_HUMAN Q8NIA3_HUMAN LTRVGAKHERHIFLFDGLMICCKSNHGQPRLPGASN-AEYRLKEKFFMRKVQINDKDDT- Q53SF8_HUMAN Q53SF8_HUMAN LTRVGAKHERHIFLFDGLMICCKSNHGQPRLPGASN-AEYRLKEKFFMRKVQINDKDDT- SOS1_HUMAN SOS1_HUMAN LTRVGAKHERHIFLFDGLMICCKSNHGQPRLPGASN-AEYRLKEKFFMRKVQINDKDDT- Q59GG9_HUMAN Q59GG9_HUMAN LTRVGAKHERHIFLFDGLMICCKSNHGQPRLPGASN-AEYRLKEKFFMRKVQINDKDDT- SOS2_MOUSE SOS2_MOUSE LTRIGAKHERHIFLFDGLMISCKPNHGQTRLPGYSS-AEYRLKEKFVMRKIQICDKEDA- Q59G32_HUMAN Q59G32_HUMAN LTRIGAKHERHIFLFDGLMISCKPNHGQTRLPGYSS-AEYRLKEKFVMRKIQICDKEDT- B7ZKT5_HUMAN B7ZKT5_HUMAN LTRIGAKHERHIFLFDGLMISCKPNHGQTRLPGYSS-AEYRLKEKFVMRKIQICDKEDT- B7ZKT6_HUMAN B7ZKT6_HUMAN LTRIGAKHERHIFLFDGLMISCKPNHGQTRLPGYSS-AEYRLKEKFVMRKIQICDKEDT- SOS2_HUMAN SOS2_HUMAN LTRIGAKHERHIFLFDGLMISCKPNHGQTRLPGYSS-AEYRLKEKFVMRKIQICDKEDT- B8A6E4_DANRE B8A6E4_DANRE LLRAGAKHERHNFLFDGLMISCKANQS-SRLPGAGSGAEFRLKEKFVLRKYRIVDREDS- Q4REE9_TETNG Q4REE9_TETNG LIRAGAKHERHNFLFDGLMISCKANQS-SRLPGAGSGAEYRLKEKFVLRKVRIVDREDS- MATCH * * ******* ********.** *:. .**** .. **:******.:** :* *::* CONSENSUS LTR?GAKHERHIFLFDGLMI?CK?NHGQ?RLPG?S??AEYRLKEKF?MRK?QI?DK?D??

Q4T188_TETNG Q4T188_TETNG GEYRHAFEIILKDGNSVVFAAKSAEEKNSWMAALISLQYHSTLERMLDSAMLREEKEEQM Q497A5_RAT Q497A5_RAT SEYKHAFEIILKDGNSVIFSAKSAEEKNNWMAALISLQYRSTLERMLDVTMLQEEKEEHM Q3USK4_MOUSE Q3USK4_MOUSE SEYKHAFEIILKDGNSVIFSAKSAEEKNNWMAALISLQYRSTLERMLDVTVLQEEKEEQM Q2M4G6_MOUSE Q2M4G6_MOUSE SEYKHAFEIILKDGNSVIFSAKSAEEKNNWMAALISLQYRSTLERMLDVTVLQEEKEEQM SOS1_MOUSE SOS1_MOUSE SEYKHAFEIILKDGNSVIFSAKSAEEKNNWMAALISLQYRSTLERMLDVTVLQEEKEEQM Q8NIA3_HUMAN Q8NIA3_HUMAN NEYKHAFEIILKDENSVIFSAKSAEEKNNWMAALISLQYRSTLERMLDVTMLQEEKEEQM Q53SF8_HUMAN Q53SF8_HUMAN NEYKHAFEIILKDENSVIFSAKSAEEKNNWMAALISLQYRSTLERMLDVTMLQEEKEEQM SOS1_HUMAN SOS1_HUMAN NEYKHAFEIILKDENSVIFSAKSAEEKNNWMAALISLQYRSTLERMLDVTMLQEEKEEQM Q59GG9_HUMAN Q59GG9_HUMAN NEYKHAFEIILKDENSVIFSAKSAEEKNNWMAALISLQYRSTLERMLDVTMLQEEKEEQM SOS2_MOUSE SOS2_MOUSE CEYRHAFELVSKDENSVIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPL Q59G32_HUMAN Q59G32_HUMAN CEHKHAFELVSKDENSIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPL B7ZKT5_HUMAN B7ZKT5_HUMAN CEHKHAFELVSKDENSIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPL B7ZKT6_HUMAN B7ZKT6_HUMAN CEHKHAFELVSKDENSIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPL SOS2_HUMAN SOS2_HUMAN CEHKHAFELVSKDENSIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPL B8A6E4_DANRE B8A6E4_DANRE PEFRHAFELVGREESGAVFSARSAEEKSAWMAALVTLQYRPTLDRMLDTVLHREEQAQPL Q4REE9_TETNG Q4REE9_TETNG AELRHAFELMGKEENCVVFCARTAEEKAAWMAALVTLQYRSTLDRMLDT----------- MATCH * :****:: :: . :*.*::**** *****::*:*:.**:**** CONSENSUS ?E??HAFE???KD?NS?IF?AKSAEEKNNWMAALISL?YRSTL?RMLD???L?EE?E???

Q4T188_TETNG Q4T188_TETNG KLPVAEVYRFAEADSEENVVFEENVQSKSGIPIIKAGTVLKLIERLTFHMYADPNFVRTF Q497A5_RAT Q497A5_RAT RLPSADVYRFAEPDSEENILFEENVQPKAGIPIIKAGTVVKLIERLTYHMYADPNFVRTF Q3USK4_MOUSE Q3USK4_MOUSE RLPSAEVYRFAEPDSEENILFEENVQPKAGIPIIKAGTVLKLIERLTYHMYADPNFVRTF Q2M4G6_MOUSE Q2M4G6_MOUSE RLPSAEVYRFAEPDSEENILFEENVQPKAGIPIIKAGTVLKLIERLTYHMYADPNFVRTF SOS1_MOUSE SOS1_MOUSE RLPSAEVYRFAEPDSEENILFEENVQPKAGIPIIKAGTVLKLIERLTYHMYADPNFVRTF Q8NIA3_HUMAN Q8NIA3_HUMAN RLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTF Q53SF8_HUMAN Q53SF8_HUMAN RLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTF SOS1_HUMAN SOS1_HUMAN RLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTF Q59GG9_HUMAN Q59GG9_HUMAN RLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTF SOS2_MOUSE SOS2_MOUSE RLPSPDMYRFVVTDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTF Q59G32_HUMAN Q59G32_HUMAN RLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTF B7ZKT5_HUMAN B7ZKT5_HUMAN RLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTF B7ZKT6_HUMAN B7ZKT6_HUMAN RLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTF SOS2_HUMAN SOS2_HUMAN RLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTF B8A6E4_DANRE B8A6E4_DANRE RLPSPDVYRFAIQDSEENIVFEEGAQSKTGIPIIKAGTVVKLIERLTYHMYADPNFVRTF Q4REE9_TETNG Q4REE9_TETNG -------------DSEENIVFEDKVQSKRGIPIIKAGTVVKLIERLTYHMYAGETLLLSP MATCH *****::**: *.: ******.***:*******:****. .:: : CONSENSUS RLPS??VYRF???DSEENI?FE?N?Q???GIPIIK?GTV?KLIERLTYHMYADPNFVRTF

Q4T188_TETNG Q4T188_TETNG LT---------TYRSFCKPQ------ELLELLMERFEIPEP------------------- Q497A5_RAT Q497A5_RAT LT---------TYRSFCKPQ------ELLNLLIERFEIPEP------------------- Q3USK4_MOUSE Q3USK4_MOUSE LT---------TYRSFCRPQ------ELLSLLIERFEIPEP------------------- Q2M4G6_MOUSE Q2M4G6_MOUSE LT---------TYRSFCRPQ------ELLSLLIERFEIPEP------------------- SOS1_MOUSE SOS1_MOUSE LT---------TYRSFCRPQ------ELLSLLIERFEIPEP------------------- Q8NIA3_HUMAN Q8NIA3_HUMAN LT---------TYRSFCKPQ------ELLSLIIERFEIPEP------------------- Q53SF8_HUMAN Q53SF8_HUMAN LT---------TYRSFCKPQ------ELLSLIIERFEIPEP------------------- SOS1_HUMAN SOS1_HUMAN LT---------TYRSFCKPQ------ELLSLIIERFEIPEP------------------- Q59GG9_HUMAN Q59GG9_HUMAN LT---------TYRSFCKPQ------ELLSLIIERFEIPEP------------------- SOS2_MOUSE SOS2_MOUSE LT---------TYRSFCKPQ------ELLNLLIERFEIPEP------------------- Q59G32_HUMAN Q59G32_HUMAN LT---------TYRSFCKPQ------ELLSLLIERFEIPEP------------------- B7ZKT5_HUMAN B7ZKT5_HUMAN LT---------TYRSFCKPQ------ELLSLLIERFEIPEP------------------- B7ZKT6_HUMAN B7ZKT6_HUMAN LT---------TYRSFCKPQ------ELLSLLIERFEIPEP------------------- SOS2_HUMAN SOS2_HUMAN LT---------TYRSFCKPQ------ELLSLLIERFEIPEP------------------- B8A6E4_DANRE B8A6E4_DANRE LT---------TYRSFCKPQ------DLLTLLIERIEIPEP------------------- Q4REE9_TETNG Q4REE9_TETNG AAEAPACASHLTLASVCRSQLRAHLPHHVPLLLQTPGAPHPADREDRDPRAGAHRGGPAG MATCH : * *.*:.* . : *::: *.* CONSENSUS LT?????????TYRSFC?PQ??????ELL?L?IERFEIPEP???????????????????

Q4T188_TETNG Q4T188_TETNG ----KPSELDQ---MEGGEQPLSPEVKRFRKEFVQ--------------------PVQLR Q497A5_RAT Q497A5_RAT ----EPTEADRIA-IENGDQPLSAELKRFRKEYIQ--------------------PVQLR Q3USK4_MOUSE Q3USK4_MOUSE ----EPTEADRIA-IENGDQPLSAELKRFRKEYIQ--------------------PVQLR Q2M4G6_MOUSE Q2M4G6_MOUSE ----EPTEADRIA-IENGDQPLSAELKRFRKEYIQ--------------------PVQLR SOS1_MOUSE SOS1_MOUSE ----EPTEADRIA-IENGDQPLSAELKRFRKEYIQ--------------------PVQLR Q8NIA3_HUMAN Q8NIA3_HUMAN ----EPTEADRIA-IENGDQPLSAELKRFRKEYIQ--------------------PVQLR Q53SF8_HUMAN Q53SF8_HUMAN ----EPTEADRIA-IENGDQPLSAELKRFRKEYIQ--------------------PVQLR SOS1_HUMAN SOS1_HUMAN ----EPTEADRIA-IENGDQPLSAELKRFRKEYIQ--------------------PVQLR Q59GG9_HUMAN Q59GG9_HUMAN ----EPTEADRIA-IENGDQPLSAELKRFRKEYIQ--------------------PVQLR SOS2_MOUSE SOS2_MOUSE ----EPTEADKLA-LEKGEQPISADLKRFRKEYVQ--------------------PVQLR Q59G32_HUMAN Q59G32_HUMAN ----EPTDADKLA-IEKGEQPISADLKRFRKEYVQ--------------------PVQLR B7ZKT5_HUMAN B7ZKT5_HUMAN ----EPTDADKLA-IEKGEQPISADLKRFRKEYVQ--------------------PVQLR B7ZKT6_HUMAN B7ZKT6_HUMAN ----EPTDADKLA-IEKGEQPISADLKRFRKEYVQ--------------------PVQLR SOS2_HUMAN SOS2_HUMAN ----EPTDADKLA-IEKGEQPISADLKRFRKEYVQ--------------------PVQLR B8A6E4_DANRE B8A6E4_DANRE ----EPSEADREA-LWNGEQPMAAELQRFRREYVQ--------------------PVQLR Q4REE9_TETNG Q4REE9_TETNG SLERRPAHGCRAAEVPEGVRAARPAQVRQRKTARRPPRKVCSQTCPQVGTGGTQAPLLLR MATCH .*:. : : * :. . * *: : *: ** CONSENSUS ????EPT?AD??A??E?G?QP?SA?LKRFRKEY?Q????????????????????PVQLR

Q4T188_TETNG Q4T188_TETNG VLNVCRHWVEHHFYDFERDPNLLRTLEEFIAS---IR----------------------- Q497A5_RAT Q497A5_RAT VLNVCRHWVEHHFYDFERDVDLLQRMEEFIGT---VR----------------------- Q3USK4_MOUSE Q3USK4_MOUSE VLNVCRHWVEHHFYDFERDADLLQRMEEFIGT---VR----------------------- Q2M4G6_MOUSE Q2M4G6_MOUSE VLNVCRHWVEHHFYDFERDADLLQRMEEFIGT---VR----------------------- SOS1_MOUSE SOS1_MOUSE VLNVCRHWVEHHFYDFERDADLLQRMEEFIGT---VR----------------------- Q8NIA3_HUMAN Q8NIA3_HUMAN VLNVCRHWVEHHFYDFERDAYLLQRMEEFIGT---VR----------------------- Q53SF8_HUMAN Q53SF8_HUMAN VLNVCRHWVEHHFYDFERDAYLLQRMEEFIGT---VR----------------------- SOS1_HUMAN SOS1_HUMAN VLNVCRHWVEHHFYDFERDAYLLQRMEEFIGT---VR----------------------- Q59GG9_HUMAN Q59GG9_HUMAN VLNVCRHWVEHHFYDFERDAYLLQRMEEFIGT---VR----------------------- SOS2_MOUSE SOS2_MOUSE VLNVFRHWVEHHYYDFERDLELLERLESFISS---VR----------------------- Q59G32_HUMAN Q59G32_HUMAN ILNVFRHWVEHHFYDFERDLELLERLESFISS---VR----------------------- B7ZKT5_HUMAN B7ZKT5_HUMAN ILNVFRHWVEHHFYDFERDLELLERLESFISS---VR----------------------- B7ZKT6_HUMAN B7ZKT6_HUMAN ILNVFRHWVEHHFYDFERDLELLERLESFISS---VR----------------------- SOS2_HUMAN SOS2_HUMAN ILNVFRHWVEHHFYDFERDLELLERLESFISS---VR----------------------- B8A6E4_DANRE B8A6E4_DANRE VLNVFRQWVEHHFYDFENDPELYERLEGYLISTTQLR----------------------- Q4REE9_TETNG Q4REE9_TETNG VLNVFRQWVEHHFYDFENDPELRSQLEEYITSKIQLRGQRSTGRPATSASSRLAPDVSLC MATCH :*** *:*****:****.* * :* :: : :* CONSENSUS ?LNV?RHWVEHHFYDFERD??LL?R?E?FI?????VR???????????????????????

Q4T188_TETNG Q4T188_TETNG --GKTMRKWVESITKIIQRKKQVQVNVPSHSITFQNSPPPIEWHICKPGNVEQFDLMTLH Q497A5_RAT Q497A5_RAT --GKAMKKWVESITKIIQRKKIARDNGPGHNITFQNSPPTVEWHISRPGHIETFDLLTLH Q3USK4_MOUSE Q3USK4_MOUSE --GKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLH Q2M4G6_MOUSE Q2M4G6_MOUSE --GKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLH SOS1_MOUSE SOS1_MOUSE --GKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLH Q8NIA3_HUMAN Q8NIA3_HUMAN --GKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLH Q53SF8_HUMAN Q53SF8_HUMAN --GKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLH SOS1_HUMAN SOS1_HUMAN --GKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLH Q59GG9_HUMAN Q59GG9_HUMAN --GKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLH SOS2_MOUSE SOS2_MOUSE --GKAMKKWVESIAKIIKRKKQAQANGISHNITFESSPPPVEWHISRTGQFETFDLMTLH Q59G32_HUMAN Q59G32_HUMAN --GKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLH B7ZKT5_HUMAN B7ZKT5_HUMAN --GKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLH B7ZKT6_HUMAN B7ZKT6_HUMAN --GKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLH SOS2_HUMAN SOS2_HUMAN --GKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLH B8A6E4_DANRE B8A6E4_DANRE --GKSMRKWVESISKIMRRKIQMQSNGISHNITFESPPPPIEWHISRPGQVDTFDLMTLH Q4REE9_TETNG Q4REE9_TETNG LTGKSMRKWVESINKIIRRKLQTQSNGVSHNITFESPPPPVEWHICRAGQVEAFDLMTLH MATCH **:*:****** **::** : * .*.***:..**.:****.:.*:.: ***:*** CONSENSUS ??GKAMKKWVESI?KII?RKK?A??NG??HNITF?S?PP??EWHIS?PG??ETFDL?TLH

Q4T188_TETNG Q4T188_TETNG PIEIARQLTLLESDFFRAVQPSELVGSVWTKEDKELHSPNLLRMIRHTTNLTLWFEKCIV Q497A5_RAT Q497A5_RAT PIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV Q3USK4_MOUSE Q3USK4_MOUSE PIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV Q2M4G6_MOUSE Q2M4G6_MOUSE PIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV SOS1_MOUSE SOS1_MOUSE PIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV Q8NIA3_HUMAN Q8NIA3_HUMAN PIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV Q53SF8_HUMAN Q53SF8_HUMAN PIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV SOS1_HUMAN SOS1_HUMAN PIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV Q59GG9_HUMAN Q59GG9_HUMAN PIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV SOS2_MOUSE SOS2_MOUSE PIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV Q59G32_HUMAN Q59G32_HUMAN PIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV B7ZKT5_HUMAN B7ZKT5_HUMAN PIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV B7ZKT6_HUMAN B7ZKT6_HUMAN PIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV SOS2_HUMAN SOS2_HUMAN PIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV B8A6E4_DANRE B8A6E4_DANRE PIEIARQLTLLESDLYRAVRPSELVGSVWTKEDKEKNSPNLLRMIRHTTNLTLWFEKCIV Q4REE9_TETNG Q4REE9_TETNG PIEIARQLTLLESELYRAVRPSELVGSVWTKEDKEKNSPNLLRMIRHTTNLTLWFEKCIV MATCH *************:::* *:*************** :*****:***************** CONSENSUS PIEIARQLTLLESDLYR?VQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV

Q4T188_TETNG Q4T188_TETNG ETENLEERVAVVSRIIEILQVFQELNNFNGLLEVVSAMNSSPVYRLDHTFE--------- Q497A5_RAT Q497A5_RAT ETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFE--------- Q3USK4_MOUSE Q3USK4_MOUSE ETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFE--------- Q2M4G6_MOUSE Q2M4G6_MOUSE ETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFE--------- SOS1_MOUSE SOS1_MOUSE ETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFE--------- Q8NIA3_HUMAN Q8NIA3_HUMAN ETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFE--------- Q53SF8_HUMAN Q53SF8_HUMAN ETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFE--------- SOS1_HUMAN SOS1_HUMAN ETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFE--------- Q59GG9_HUMAN Q59GG9_HUMAN ETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFE--------- SOS2_MOUSE SOS2_MOUSE EAENFEERVAVLSRIVEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFE--------- Q59G32_HUMAN Q59G32_HUMAN EAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFE--------- B7ZKT5_HUMAN B7ZKT5_HUMAN EAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFE--------- B7ZKT6_HUMAN B7ZKT6_HUMAN EAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFE--------- SOS2_HUMAN SOS2_HUMAN EAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFE--------- B8A6E4_DANRE B8A6E4_DANRE EAENVDERVAVFSRIIEILQVFQELNNFNGVLEIVSAINSVPVYRLDHTFE--------- Q4REE9_TETNG Q4REE9_TETNG ETMNLEERVAVLLRVIEILQVFQELNNFNGVLEVVSAINSVPIYRLDHTFEVRTARTHTH MATCH *: *.:*****. *::*******:******:**:***:** .:******** CONSENSUS E?EN?EERVAV?SRIIEILQVFQ?LNNFNGVLE?VSA?NS??VYRLDHTFE?????????

Q4T188_TETNG Q4T188_TETNG ---------------QLTSRQRKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGALLGS Q497A5_RAT Q497A5_RAT ---------------QIPSRQKK------------------------------------- Q3USK4_MOUSE Q3USK4_MOUSE ---------------QIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFF------ Q2M4G6_MOUSE Q2M4G6_MOUSE ---------------QIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFF------ SOS1_MOUSE SOS1_MOUSE ---------------QIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFF------ Q8NIA3_HUMAN Q8NIA3_HUMAN ---------------QIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFF------ Q53SF8_HUMAN Q53SF8_HUMAN ---------------QIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFF------ SOS1_HUMAN SOS1_HUMAN ---------------QIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFF------ Q59GG9_HUMAN Q59GG9_HUMAN ---------------QIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFF------ SOS2_MOUSE SOS2_MOUSE ---------------ALQERKRRILDDAVELSQDHFKKYLVKLKSINPPCVPFF------ Q59G32_HUMAN Q59G32_HUMAN ---------------ALQERKRKILDEAVELSQDHFKKYLVKLKSINPPCVPFF------ B7ZKT5_HUMAN B7ZKT5_HUMAN ---------------ALQERKRKILDEAVELSQDHFKKYLVKLKSINPPCVPFF------ B7ZKT6_HUMAN B7ZKT6_HUMAN ---------------ALQERKRKILDEAVELSQDHFKKYLVKLKSINPPCVPFF------ SOS2_HUMAN SOS2_HUMAN ---------------ALQERKRKILDEAVELSQDHFKKYLVKLKSINPPCVPFF------ B8A6E4_DANRE B8A6E4_DANRE ---------------AVPERKRRILEEAVELSQDHFKKYLAKLKSINPPCVPFF------ Q4REE9_TETNG Q4REE9_TETNG THTRQIGFNCFFLLQAIPERKRRVLEEAVELSQDHFKKYLAKLKSINPPCVPFF------ MATCH : .*::: CONSENSUS ???????????????????R??KIL?EA?ELS?DH?KKYL?KL?SINPPCVPFF??????

Q4T188_TETNG Q4T188_TETNG LRLRTGNRFPQSSRHLCVSSGIYLTNILKTEEGNPDFLLRHGKHLINFSKRRKVAEITGE Q497A5_RAT Q497A5_RAT ------------------------------------------------------------ Q3USK4_MOUSE Q3USK4_MOUSE --------------------GIYLTNILKTEEGNPEVLRRHGKELINFSKRRRVAEITGE Q2M4G6_MOUSE Q2M4G6_MOUSE --------------------GIYLTNILKTEEGNPEVLRRHGKELINFSKRRRVAEITGE SOS1_MOUSE SOS1_MOUSE --------------------GIYLTNILKTEEGNPEVLRRHGKELINFSKRRRVAEITGE Q8NIA3_HUMAN Q8NIA3_HUMAN --------------------GIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGE Q53SF8_HUMAN Q53SF8_HUMAN --------------------GIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGE SOS1_HUMAN SOS1_HUMAN --------------------GIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGE Q59GG9_HUMAN Q59GG9_HUMAN --------------------GIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGE SOS2_MOUSE SOS2_MOUSE --------------------GIYLTNILKTEEGNSDFLKRKGKDLINFSKRRKVAEITGE Q59G32_HUMAN Q59G32_HUMAN --------------------GIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGE B7ZKT5_HUMAN B7ZKT5_HUMAN --------------------GIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGE B7ZKT6_HUMAN B7ZKT6_HUMAN --------------------GIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGE SOS2_HUMAN SOS2_HUMAN --------------------GIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGE B8A6E4_DANRE B8A6E4_DANRE --------------------GIYLTNILKTEEGNPDFLKRDGKELINFSKRRKVAEITGE Q4REE9_TETNG Q4REE9_TETNG --------------------GIYLTNILKTEEGNPDFLTRHGKELINFSKRRKVAEITGE MATCH CONSENSUS ????????????????????GIYLTNILKTEEGN???L???GK?LINFSKRR?VAEITGE

Q4T188_TETNG Q4T188_TETNG IQQYQNQPYCLRVDSDIRESGCCCDTLFRLCEQKFFENLNPMEDVSEKDFSDHLFNKSLE Q497A5_RAT Q497A5_RAT ------------------------------------------------------------ Q3USK4_MOUSE Q3USK4_MOUSE IQQYQNQPYCLRVEPDIK---------------RFFENLNPMGNSMEKEFTDYLFNKSLE Q2M4G6_MOUSE Q2M4G6_MOUSE IQQYQNQPYCLRVEPDIK---------------RFFENLNPMGNSMEKEFTDYLFNKSLE SOS1_MOUSE SOS1_MOUSE IQQYQNQPYCLRVEPDIK---------------RFFENLNPMGNSMEKEFTDYLFNKSLE Q8NIA3_HUMAN Q8NIA3_HUMAN IQQYQNQPYCLRVESDIK---------------RFFENLNPMGNSMEKEFTDYLFNKSLE Q53SF8_HUMAN Q53SF8_HUMAN IQQYQNQPYCLRVESDIK---------------RFFENLNPMGNSMEKEFTDYLFNKSLE SOS1_HUMAN SOS1_HUMAN IQQYQNQPYCLRVESDIK---------------RFFENLNPMGNSMEKEFTDYLFNKSLE Q59GG9_HUMAN Q59GG9_HUMAN IQQYQNQPYCLRVESDIK---------------RFFENLNPMGNSMEKEFTDYLFNKSLE SOS2_MOUSE SOS2_MOUSE IQQYQNQPYCLRTEPEMR---------------RFFENLNPMGILSEKEFTDYLFNKSLE Q59G32_HUMAN Q59G32_HUMAN IQQYQNQPYCLRIEPDMR---------------RFFENLNPMGSASEKEFTDYLFNKSLE B7ZKT5_HUMAN B7ZKT5_HUMAN IQQYQNQPYCLRIEPDMR---------------RFFENLNPMGSASEKEFTDYLFNKSLE B7ZKT6_HUMAN B7ZKT6_HUMAN IQQYQNQPYCLRIEPDMR---------------RFFENLNPMGSASEKEFTDYLFNKSLE SOS2_HUMAN SOS2_HUMAN IQQYQNQPYCLRIEPDMR---------------RFFENLNPMGSASEKEFTDYLFNKSLE B8A6E4_DANRE B8A6E4_DANRE IQQYQNQPYCLKVEHDIK---------------RFFENLNPMGNMNEKDFSDYLFNKSLE Q4REE9_TETNG Q4REE9_TETNG IQQYQNQPYCLKVEHEIR---------------RFFENLNPMGNMGEKEFADYLFKMSLD MATCH CONSENSUS IQQYQNQPYCLR?E?D?????????????????RFFENLNPMG???EKEF?DYLFNKSLE

Q4T188_TETNG Q4T188_TETNG IEPRNARTLPRFGKKYSCPLKSPGIRPTSVR----SGTMR-HPTPLQSE-PRKISYSRVP Q497A5_RAT Q497A5_RAT -------------KK--------------------------------------------- Q3USK4_MOUSE Q3USK4_MOUSE IEPRHPKPLPRFPKKYSYPLKSPGVRPSNPR----PGTMR-HPTPLQQE-PRKISYSRIP Q2M4G6_MOUSE Q2M4G6_MOUSE IEPRHPKPLPRFPKKYSYPLKSPGVRPSNPR----PGTMR-HPTPLQQE-PRKISYSRIP SOS1_MOUSE SOS1_MOUSE IEPRHPKPLPRFPKKYSYPLKSPGVRPSNPR----PGTMR-HPTPLQQE-PRKISYSRIP Q8NIA3_HUMAN Q8NIA3_HUMAN IEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR----PGTMR-HPTPLQQE-PRKISYSRIP Q53SF8_HUMAN Q53SF8_HUMAN IEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR----PGTMR-HPTPLQQE-PRKISYSRIP SOS1_HUMAN SOS1_HUMAN IEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR----PGTMR-HPTPLQQE-PRKISYSRIP Q59GG9_HUMAN Q59GG9_HUMAN IEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR----PGTMR-HPTPLQQE-PRKISYSRIP SOS2_MOUSE SOS2_MOUSE IEPRNCKQPPRFPRKSTFSLKSPGIRPNAGRHGSTSGTLRGHPTPLERE-PYKISFSRIA Q59G32_HUMAN Q59G32_HUMAN IEPRNCKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLERE-PCKISFSRIA B7ZKT5_HUMAN B7ZKT5_HUMAN IEPRNCKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLERE-PCKISFSRIA B7ZKT6_HUMAN B7ZKT6_HUMAN IEPRNCKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLERE-PCKISFSRIA SOS2_HUMAN SOS2_HUMAN IEPRNCKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLERE-PCKISFSRIA B8A6E4_DANRE B8A6E4_DANRE IEPRNSKQPPRFPRKTTYSLKSPGVRPVRQAVGG-GGTLKGHPVPLEREPPHKITFRSIA Q4REE9_TETNG Q4REE9_TETNG IEPRNCRQPPRFPRKTVYPLKSPGIRPVRTS---TSGTLKGHPVPLEREPPHKITFRSIP MATCH :* CONSENSUS IEPR??K??PRFP?K????LKSPG?RP???R?????GT?R?HPTPL??E?P?KIS?SRI?

Q4T188_TETNG Q4T188_TETNG DSEVEGA--TVSAPNSPR Q4T188_TETNG Q4T188_TETNG DSEEEEEEEEEEEEEE---ur97A5_RATame ="ident" value =r = GREEN>S Q3USK4_MOUSE Q3USK4_MOUSE I I I Q4T188_TETNG RDSEEEEEEEEEEEEEE---Q4T188_TETNG RDSEEEEEEEEEEEEEE---Q4T188_TETNG RDSEEEEEEEEEEEEEE---Q4T188_TETNG RDSEEEEEEEEPSNP :* Q4T188_TETNG RDSEEEEEEEEEEEEEEPPLPRFPR Q4T188_TETNG RDSEEEEEEEEEEEEEEPPLPRFPR Q4T188_TETNG RDSEEEEEEEEEEEEEE---Q4T188_TETNG Q4T188_TETNG DSEEPEEEEEEEE---Q4T188_TETNG Q4T188_TETNG DSEEPEEEEEEEE---Q4T188_TETNG Q4T188_TETNG DSEEPEEEEEEEE---Q4T188_TETNG Q4T188_TETNG DSEEPEEEEEEEE---Q4T188_TETNG Q4T188_TETNG DSEEPEEEEEEEE---Q3USK4_MOUSE Q3USK4_MOUSE Q3USK4_MOUSE Q3USK4_MOUSE I
Q4T188_TETNG Q4T188_TETNG DSEVEGA--TVSAPNur97A5_RATame ="ident" value =r = Ge LACK>---
Q4T188_TETNG Q4T188_TETNG DSEVEGA--TVSAPNur97A5_RATame ="ident" value =r = Ge LACK>---
Q4T188_TETNG Q4T188_TETNG DSEVEGA--TVSAPNur97A5_RATame ="ident" value =r = Ge LACK>---
Q4T188_TETNG Q4T188_TETNG DSEVEGA--TVSAPNur97A5_RATame ="ident" value =r = Ge LACK>---
Q4T188_TETNG Q4T188_TETNG
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