Alignment of the gene Family HBG050478 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
A8K8U8_HUMAN A8K8U8_HUMAN MAYSDTTMMSDDIDWLRSHRGVCKVDLYNPEGQQDQDRKVICFVDVSTLNVEDKDYKDAA AKAP4_HUMAN AKAP4_HUMAN MAYSDTTMMSDDIDWLRSHRGVCKVDLYNPEGQQDQDRKVICFVDVSTLNVEDKDYKDAA Q9XS94_BOVIN Q9XS94_BOVIN --------MSDDIDWLHSRRGVCKVDLYSPRGQQDQDRKVICFVDVSTLSMEDKDSKDAA Q925F9_MESAU Q925F9_MESAU ----------DDIDWLHSRRGVCKVDLYSPKGQQDQDRKVICFVDVSTLNVEDKDSKGAA A1L3T6_MOUSE A1L3T6_MOUSE IAYCGTTTMSDDIDWLHSRRGVCKVDLYSPKGQQDQDRKVICFVDVSTLNVEDKDSKGAA AKAP4_MOUSE AKAP4_MOUSE IAYCGTTTMSDDIDWLHSRRGVCKVDLYSPKGQQDQDRKVICFVDVSTLNVEDKDSKGAA AKAP4_RAT AKAP4_RAT IAYCGTTKMSDDIDWLHSRRGVCKVDLYSPEGQQDQDRKVICFVDVSTLNVED-DSKGAA Q9Z263_MOUSE Q9Z263_MOUSE --------MSDDIDWLHSRRGVCKVDLYSPKGQQDQDRKVICFVDVSTLNVEDFNSKGAA Q66HC6_RAT Q66HC6_RAT --------MADRVDWLQSQSGVCKVGVYSPGDNQHQDWKM-------------------- AKAP3_MOUSE AKAP3_MOUSE --------MADRVDWLQSQSGVCKVGVYSPGDNQHQDWKM-------------------- Q497M9_MOUSE Q497M9_MOUSE --------MADRVDWLQSQSGVCKVGVYSPGDNQHQDWKM-------------------- AKAP3_BOVIN AKAP3_BOVIN --------MSDRVDWLQSQNGVCKVDVYSPGDSQPQDWKM-------------------- AKAP3_HUMAN AKAP3_HUMAN --------MSEKVDWLQSQNGVCKVDVYSPGDNQAQDWKM-------------------- B3KQD0_HUMAN B3KQD0_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ????????M?D??DWL?S??GVCKV??Y?P???Q?QD?K?????????????????????

A8K8U8_HUMAN A8K8U8_HUMAN SSSSEGNLNLGSLEEKEIIVIKDTEKKDQSKTEGSVCLFKQAPSDPVSVLNWLLSDLQKY AKAP4_HUMAN AKAP4_HUMAN SSSSEGNLNLGSLEEKEIIVIKDTEKKDQSKTEGSVCLFKQAPSDPVSVLNWLLSDLQKY Q9XS94_BOVIN Q9XS94_BOVIN GCSSEGDLNLENLEEKEIIVIKDTEKQDQSKTEGSVCLFKQAPSDPLSVFNWLLNDLQKY Q925F9_MESAU Q925F9_MESAU GSRSEGELDLENLEEKEIIVIKDTEKQDQSKTEGSVCLFKQAPSDPISVLNWLLNDLQKY A1L3T6_MOUSE A1L3T6_MOUSE GSRSEGELNLETLEEKEIIVIKDTEKQDQSKTEGSVCLFKQAPSDPISVLNWLLNDLQKY AKAP4_MOUSE AKAP4_MOUSE GSRSEGELNLETLEEKEIIVIKDTEKQDQSKTEGSVCLFKQAPSDPISVLNWLLNDLQKY AKAP4_RAT AKAP4_RAT GPRSDGELNLENLEEKEIIVIKDTEKQDQPKTEGSVCLFKQAPSDPISVLNWLLNDLQKY Q9Z263_MOUSE Q9Z263_MOUSE GPRSEGELNLENLEEKEIIVIKDTEKQDQSKTEGSVCLFKQAPSDPISVLNWLLNDLQKY Q66HC6_RAT Q66HC6_RAT ----------------------------------------DSSTDPVRVLSWLRKDLEKS AKAP3_MOUSE AKAP3_MOUSE ----------------------------------------DTSTDPVRVLSWLRKDLEKS Q497M9_MOUSE Q497M9_MOUSE ----------------------------------------DTSTDPVRVLSWLRKDLEKS AKAP3_BOVIN AKAP3_BOVIN -------------------------------SDESLSIFKEASHDPIRVLSWLRRDLEKS AKAP3_HUMAN AKAP3_HUMAN ----------------------------------------DTSTDPVRVLSWLRRDLEKS B3KQD0_HUMAN B3KQD0_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????DP??VL?WL??DL?K?

A8K8U8_HUMAN A8K8U8_HUMAN ALGFQHALSPSTSTCKHKVGDTEGEYHRASSENCYSVYADQVNIDYLMNRPQNLRLEMTA AKAP4_HUMAN AKAP4_HUMAN ALGFQHALSPSTSTCKHKVGDTEGEYHRASSENCYSVYADQVNIDYLMNRPQNLRLEMTA Q9XS94_BOVIN Q9XS94_BOVIN ALGFQHALSPSASSCKHKVGETEGNCQKLSSGNCYSIYANHLNMDCVNNEPQSLRLEMTA Q925F9_MESAU Q925F9_MESAU ALGFQHALSPSASSCKHKVGDLEGDYHKIPSENCYSVYADQLNMDFLNKGPQSLRLEMAA A1L3T6_MOUSE A1L3T6_MOUSE ALGFQHALSPSASSCKHKVGDLEGDYSKIPSENCYSVYADQVNFDYLNKGPQNLRLEMAA AKAP4_MOUSE AKAP4_MOUSE ALGFQHALSPSASSCKHKVGDLEGDYSKIPSENCYSVYADQVNFDYLNKGPQNLRLEMAA AKAP4_RAT AKAP4_RAT ALGFQHALSPSASSCKHKVGDLEGDYHKIPSENCYSVYADQVNLDYLNKGPQNLRLEMAA Q9Z263_MOUSE Q9Z263_MOUSE ASGFQQALSPSASSCKHKVGDLEGDYHKIPSEECYSVYADQVNLDYLNKGPQNLRLEMAA Q66HC6_RAT Q66HC6_RAT TAGFQDSRFKPGESSFGEEVAYPGDQRKGFCVDYYNTTN--------KGNPGRLHFEMSH AKAP3_MOUSE AKAP3_MOUSE TAGFQDSRFKPGESSFVEEVAYPVDQRKGFCVDYYNTTN--------KGSPGRLHFEMSH Q497M9_MOUSE Q497M9_MOUSE TAGFQDSRFKPGESSFVEEVAYPVDQRKGFCVDYYNTTN--------KGSPGRLHFEMSH AKAP3_BOVIN AKAP3_BOVIN TAGFQDIRFKPGESSLGREMVSSGDPRKGFCVDYYNTTS--------RGSPGRLHFEMSH AKAP3_HUMAN AKAP3_HUMAN TAEFQDVRFKPGES-FGGETSNSGDPHKGFSVDYYNTTT--------KGTPERLHFEMTH B3KQD0_HUMAN B3KQD0_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ??GFQ?????????????????????????????Y???????????????P??L??EM??

A8K8U8_HUMAN A8K8U8_HUMAN AKNTNNNQSPSAPPAKPPSTQRAVISPDGECSIDDLSFYVNRLSSLVIQMAHKEIKEKLE AKAP4_HUMAN AKAP4_HUMAN AKNTNNNQSPSAPPAKPPSTQRAVISPDGECSIDDLSFYVNRLSSLVIQMAHKEIKEKLE Q9XS94_BOVIN Q9XS94_BOVIN AKNTNNNQSPSTPPGKSPSNQRAVISPDGECSMDDLSFYVNRLSSLVIQMARKEIKEKLE Q925F9_MESAU Q925F9_MESAU SKNTNNNQSPSNPAAKSPSNQRSVATSDAECSMDDLSFYVNRLSSLVIQMARKEIKDKLE A1L3T6_MOUSE A1L3T6_MOUSE SKNTNNNQSPSNPATKSPSNQRSVATPEGECSMDDLSFYVNRLSSLVIQMARKEIKDKLE AKAP4_MOUSE AKAP4_MOUSE SKNTNNNQSPSNPATKSPSNQRSVATPEGECSMDDLSFYVNRLSSLVIQMARKEIKDKLE AKAP4_RAT AKAP4_RAT SKNTNNNQSPSNPATKSPSNQRSVATPDGECSMDDLSYYVNRLSSLVIQMARKEIKDKLE Q9Z263_MOUSE Q9Z263_MOUSE SKNTNNNQSPSNPATKSPSNQRSVATPDGECSMDDLSYYVNRLSSLVIQMARKEIKDKLE Q66HC6_RAT Q66HC6_RAT KET---------------PPQGLIAHVGNGGSIDEVSFYANRLTNLVIAMARKEINEKIH AKAP3_MOUSE AKAP3_MOUSE KEN---------------PSQGLISHVGNGGSIDEVSFYANRLTNLVIAMARKEINEKIH Q497M9_MOUSE Q497M9_MOUSE KEN---------------PSQGLISHVGNGGSIDEVSFYANRLTNLVIAMARKEINEKIH AKAP3_BOVIN AKAP3_BOVIN REN---------------PHQGPTC---NGSSVDEVSFYANRLTNLVIAMARKEINEKID AKAP3_HUMAN AKAP3_HUMAN KEI---------------PCQGPRAQLGNGSSVDEVSFYANRLTNLVIAMARKEINEKID B3KQD0_HUMAN B3KQD0_HUMAN -------------------------------------------------MARKEINEKID MATCH **:***::*:. CONSENSUS ????????????????????Q??????????S?D??S?Y?NRL??LVI?MARKEI??K??

A8K8U8_HUMAN A8K8U8_HUMAN GK-SKCLHHSICPSPGNKERISPRTPASKIASEMAYEAV--------------------- AKAP4_HUMAN AKAP4_HUMAN GK-SKCLHHSICPSPGNKERISPRTPASKIASEMAYEAV--------------------- Q9XS94_BOVIN Q9XS94_BOVIN NG-SKCLHHSIYPPSGDKGKNSPRSAVSKIASEMAHDAV--------------------- Q925F9_MESAU Q925F9_MESAU GG-SKCLHHSIYASPGEKGKTSPRSAVSKIASEMAHEAV--------------------- A1L3T6_MOUSE A1L3T6_MOUSE GG-SKCLHHSMYTS-GDKGKTSPRSAVSKIASEMAHEAV--------------------- AKAP4_MOUSE AKAP4_MOUSE GG-SKCLHHSMYTS-GDKGKTSPRSAVSKIASEMAHEAV--------------------- AKAP4_RAT AKAP4_RAT GG-NKCLHHSMYTS-GEKGKTSPRSAVSKIASEMAHEAV--------------------- Q9Z263_MOUSE Q9Z263_MOUSE GG-NKCLHHSMYTS-GEKGKTSPRSAVSKIASEMAHEAV--------------------- Q66HC6_RAT Q66HC6_RAT GTENKCVHQSLYMG----DDPTPHKSLSTVASELVNETVSACSKNITGDKAPGSGDRALA AKAP3_MOUSE AKAP3_MOUSE GAENKCVHQSLYMG----DEPTPHKSLSTVASELVNETVTACSKNISSDKAPGSGDRASG Q497M9_MOUSE Q497M9_MOUSE GAENKCVHQSLYMG----DEPTPHKSLSTVASELVNETVTACSKNISSDKAPGSGDRASG AKAP3_BOVIN AKAP3_BOVIN GSENRCVHQSVYMG----DEPPPNKSLSKVASELVNETVTACSKNTPSDKAPGSGDRASG AKAP3_HUMAN AKAP3_HUMAN GSENKCVYQSLYMG----NEPTPTKSLSKIASELVNETVSACSRNAAPDKAPGSGDRVSG B3KQD0_HUMAN B3KQD0_HUMAN GSENKCVYQSLYMG----NEPTPTKSLSKIASELVNETVSACSRNAAPDKAPGSGDRVSG MATCH . .:*:::*: .* .. *.:***:. ::* CONSENSUS G???KC?H?S?Y??????????P????S??ASE???E?V?????????????????????

A8K8U8_HUMAN A8K8U8_HUMAN --------------ELTAAEMRGTGEESREGGQKSFLYSELSNKSKSGDK-Q---MSQRE AKAP4_HUMAN AKAP4_HUMAN --------------ELTAAEMRGTGEESREGGQKSFLYSELSNKSKSGDK-Q---MSQRE Q9XS94_BOVIN Q9XS94_BOVIN --------------EVTSAEMRGTGEECRDGGRKTFLYSELSNKNKGGDK-Q---MCQRD Q925F9_MESAU Q925F9_MESAU --------------ELTSAEMRGNGEECRDG-RKTFLYSELSNKNKCGEK-Q---MCPKD A1L3T6_MOUSE A1L3T6_MOUSE --------------ELTSSEMRGNGEDCRDG-RKTFLYSEMCNKNKCGEKQQ---MCPKD AKAP4_MOUSE AKAP4_MOUSE --------------ELTSSEMRGNGEDCRDG-RKTFLYSEMCNKNKCGEKQQ---MCPKD AKAP4_RAT AKAP4_RAT --------------ELTSSEMRGNGEEGRDG-RKTFLYSELSNKNKCGEKQQ---MCPKD Q9Z263_MOUSE Q9Z263_MOUSE --------------ELTSSEMRGNGEEGRDG-RKTFLYSELSNKNKCGEKQQ---MCPKD Q66HC6_RAT Q66HC6_RAT SSQS-PGLRFTSTLKIKESTKEGKCPDNKPGSKKSFFYKEVFESRNAGDAKEGGRSLPGD AKAP3_MOUSE AKAP3_MOUSE SSQA-PGLRYMSTLKIKESTKEGKCPDDKPGTKKSFFYKEVFESRNAGDAKEGGRSLPGD Q497M9_MOUSE Q497M9_MOUSE SSQA-PGLRYTSTLKIKESTKEGKCPDDKPGTKKSFFYKEVFESRNAGDAKEGGRSLPGD AKAP3_BOVIN AKAP3_BOVIN TLQSPPNLKYKSTLKIKESNKGGRGPDDRPSSKKSFFYKEVFESRNAGDAKEGGRTLPAE AKAP3_HUMAN AKAP3_HUMAN SSQSPPNLKYKSTLKIKESTKERQGPDDKPPSKKSFFYKEVFESRNGDYAREGGRFFPRE B3KQD0_HUMAN B3KQD0_HUMAN SSQSPPNLKYKSTLKIKESTKERQGPDDKPPSKKSFFYKEVFESRNGDYAREGGRFFPRE MATCH ::. : : : :*:*:*.*: :. : . : : CONSENSUS ??????????????????????G??????????K?F?Y?E???????G????????????

A8K8U8_HUMAN A8K8U8_HUMAN SK-----------EFADSISKGLMVYANQVASDMMVSLMKTLKVHSSGKPIPASVVLKRV AKAP4_HUMAN AKAP4_HUMAN SK-----------EFADSISKGLMVYANQVASDMMVSLMKTLKVHSSGKPIPASVVLKRV Q9XS94_BOVIN Q9XS94_BOVIN SK-----------DFADSISKGLMVYANQVASDMMVSVMKTLKVHSSGKPIPACVVLKRV Q925F9_MESAU Q925F9_MESAU SK-----------EFADSISKGLMVYANQVASDMMVSVMKTLKVHSCGKPIPACVVLKRV A1L3T6_MOUSE A1L3T6_MOUSE SK-----------EFADSISKGLMVYANQVASDMMVSVMKTLKVHSCGKPIPACVVLKRV AKAP4_MOUSE AKAP4_MOUSE SK-----------EFADSISKGLMVYANQVASDMMVSVMKTLKVHSCGKPIPACVVLKRV AKAP4_RAT AKAP4_RAT SK-----------EFADSISKGLMVYANQVASDMMVSVMKTLKVHSCGKPIPACVVLKRV Q9Z263_MOUSE Q9Z263_MOUSE SK-----------EFADSISKGLMVYANQVASDMMVSVMKTLKVHSCGKPIPACVVLKRV Q66HC6_RAT Q66HC6_RAT RKLFRCP--DRPDDFSNSISQGIMTYANSVVSDMMVSIMKTLKIQVKDTTI-ATILLKKV AKAP3_MOUSE AKAP3_MOUSE QKLFRTSPDNRPDDFSNSISQGIMTYANSVVSDMMVSIMKTLKIQVKDTTI-ATILLKKV Q497M9_MOUSE Q497M9_MOUSE QKLFRTSPDNRPDDFSNSISQGIMTYANSVVSDMMVSIMKTLKIQVKDTTI-ATILLKKV AKAP3_BOVIN AKAP3_BOVIN RKMFRGY--ERPDDFTASISQGIMTYANSVVSDMMVSIMKTLKIQVKDTTI-ATIVLKKV AKAP3_HUMAN AKAP3_HUMAN RKRFRGQ--ERPDDFTASVSEGIMTYANSVVSDMMVSIMKTLKIQVKDTTI-ATILLKKV B3KQD0_HUMAN B3KQD0_HUMAN RKRFRGQ--ERPDDFTASVSEGIMTYANSVVSDMMVSIMKTLKIQVKDTTI-ATILLKKV MATCH * :*: *:*:*:*.***.*.******:*****:: ...* * ::**:* CONSENSUS ?K????????????F??SIS?G?M?YAN?V?SDMMVS?MKTLK???????I?A???LK?V

A8K8U8_HUMAN A8K8U8_HUMAN LLRHTKEIVSDLIDSCMKNLHNITGVLMTDSDFVSAVKRNLFNQWKQNATDIMEAMLKRL AKAP4_HUMAN AKAP4_HUMAN LLRHTKEIVSDLIDSCMKNLHNITGVLMTDSDFVSAVKRNLFNQWKQNATDIMEAMLKRL Q9XS94_BOVIN Q9XS94_BOVIN LLKHTKEIVSDLIDSCMKNLHNITGVLMTDSDFVSAVKRNLFNHGKQNAADIMEAMLKRL Q925F9_MESAU Q925F9_MESAU LLKHTKEIVSDLIDSCMKNLHNITGVLMTDSDFVSAVKRNLFNHGKQNAADIMEAMLKRL A1L3T6_MOUSE A1L3T6_MOUSE LLKHTKEIVSDLIDSCMKNLHNITGVLMTDSDFVSAVKRNLFNHGKQNAADIMEAMLKRL AKAP4_MOUSE AKAP4_MOUSE LLKHTKEIVSDLIDSCMKNLHNITGVLMTDSDFVSAVKRNLFNHGKQNAADIMEAMLKRL AKAP4_RAT AKAP4_RAT LLKHTKEIVSDLIDSCMKNLHNITGVLMTDSDFVSAVKRNLFNHGKQNAADIMEAMLKRL Q9Z263_MOUSE Q9Z263_MOUSE LLKHTKEIVSDLIDSCMKNLHNITGVLMTDSDFVSAVKRNLFNHGKQNAADIMEAMLKRL Q66HC6_RAT Q66HC6_RAT LMKHAKEVVSDLIDSFMKNLHSVTGSLMTDTDFVSAVKRSFFSHGSQKATDIMDAMLGKL AKAP3_MOUSE AKAP3_MOUSE LMKHAKEVVSDLIDSFMKNLHGVTGSLMTDTDFVSAVKRSFFSHGSQKATDIMDAMLGKL Q497M9_MOUSE Q497M9_MOUSE LMKHAKEVVSDLIDSFMKNLHGVTGSLMTDTDFVSAVKRSFFSHGSQKATDIMDAMLGKL AKAP3_BOVIN AKAP3_BOVIN LIKHAKEVVSDLIDSFMKNLHNVTGTLMTDTDFVSAVKRSFFSHGSQKATDIMDAMLGKL AKAP3_HUMAN AKAP3_HUMAN LLKHAKEVVSDLIDSFLRNLHSVTGTLMTDTQFVSAVKRTVFSHGSQKATDIMDAMLRKL B3KQD0_HUMAN B3KQD0_HUMAN LLKHAKEVVSDLIDSFLRNLHSVTGTLMTDTQFVSAVKRTVFSHGSQKATDIMDAMLRKL MATCH *::*:**:******* ::***.:** ****::*******..*.: .*:*:***:*** :* CONSENSUS L?KH?KE?VSDLIDS?MKNLH??TG?LMTD?DFVSAVKR??F?HG?Q?A?DIM?AML??L

A8K8U8_HUMAN A8K8U8_HUMAN VSALIGEE-------KETKSQSLSYASLKAGSHDPKCRNQSLEFSTMKAEMKERDK---- AKAP4_HUMAN AKAP4_HUMAN VSALIGEE-------KETKSQSLSYASLKAGSHDPKCRNQSLEFSTMKAEMKERDK---- Q9XS94_BOVIN Q9XS94_BOVIN VSALLGEK-------KETKSQCLSYTSLKAGSHDAKCKNQSLEFSSVKAEMKGKDK---- Q925F9_MESAU Q925F9_MESAU VSALLGEK-------KETKSQSLAYATLKAGTHDPKCKNQSLEFSAMKAEMKGKDK---- A1L3T6_MOUSE A1L3T6_MOUSE VSALLGEK-------KETKSQSLAYATLKAGTNDPKCKNQSLEFSAMKAEMKGKDK---- AKAP4_MOUSE AKAP4_MOUSE VSALLGEK-------KETKSQSLAYATLKAGTNDPKCKNQSLEFSAMKAEMKGKDK---- AKAP4_RAT AKAP4_RAT VSALLGEK-------KETKSQSLAYATLKAGTHDPKCKNQSLEFSAMKAEMKGKDK---- Q9Z263_MOUSE Q9Z263_MOUSE VSALLGEK-------KETKSQSLAYATLKAGTHDPKCKNQSLEFSAMKAEMKGKDK---- Q66HC6_RAT Q66HC6_RAT YNVMCAKKYPENIRKARDKSESYSLISMKSRPGDPKLSNLN--FA-MKSESKLKENLFSA AKAP3_MOUSE AKAP3_MOUSE YNVMFAKKFPENIRRARDKSESYSLISTKSRAGDPKLSNLN--FA-MKSESKLKENLFST Q497M9_MOUSE Q497M9_MOUSE YNVMFAKKFPENIRRARDKSESYSLISTKSRAGDPKLSNLN--FA-MKSESKLKENLFST AKAP3_BOVIN AKAP3_BOVIN YSVIFAKKPPETVRKTKDKSESYSLVSMK-GMGDPKHRNVN--FASMKSEGKVRERVCT- AKAP3_HUMAN AKAP3_HUMAN YNVMFAKKVPEHVRKAQDKAESYSLISMK-GMGDPKNRNVN--FA-MKSETKLREKMYS- B3KQD0_HUMAN B3KQD0_HUMAN YNVMFAKKVPEHVRKAQDKAESYSLISMK-GMGDPKNRNVN--FA-MKSETKLREKMYS- MATCH ..: .:: . *::. : : * *.* * . *: :*:* * ::. CONSENSUS ???????K??????????KS?S??????K????DPK??N????F??MK?E?K????????

A8K8U8_HUMAN A8K8U8_HUMAN GKMKSDP-CKSLTSAEKVGEHILKEGLTIW-NQKQG----------------NSCKVATK AKAP4_HUMAN AKAP4_HUMAN GKMKSDP-CKSLTSAEKVGEHILKEGLTIW-NQKQG----------------NSCKVATK Q9XS94_BOVIN Q9XS94_BOVIN CKVKQEE-CKSLTSAEKVSEHILKESLTMW-NQKQC----------------NQGKMPSK Q925F9_MESAU Q925F9_MESAU CKVKTDPCCKSLTSAEKVGEHILKESLTMW-NQKQG----------------NQGRVTTN A1L3T6_MOUSE A1L3T6_MOUSE CKSKADPCCKSLTSAERVSEHILKESLTMWNNQKQG----------------NQGKVTNK AKAP4_MOUSE AKAP4_MOUSE CKSKADPCCKSLTSAERVSEHILKESLTMWNNQKQG----------------NQGKVTNK AKAP4_RAT AKAP4_RAT GKTKGDPCCKSLTSAERVSEHILKESLTMWNNQKQG----------------TQGRVPNK Q9Z263_MOUSE Q9Z263_MOUSE GKTKGDPCCKSLTSAERVSEHILKESLTMWNNQKQG----------------TQGRVPNK Q66HC6_RAT Q66HC6_RAT CISEKEKTC-----AETLGEHIIKEGLNMWHKSQQN---SPGLERAT-----KQGAVPQE AKAP3_MOUSE AKAP3_MOUSE CKLEKEKTC-----AETLGEHIIKEGLHMWHKSQQK---SPGLERAA-----KLGNAPQE Q497M9_MOUSE Q497M9_MOUSE CKLEKEKTC-----AETLGEHIIKEGLHMWHKSQQK---SPGLERAA-----KLGNAPQE AKAP3_BOVIN AKAP3_BOVIN PTPKPEKSC-----VETLGEHIIKEGLTLWHNSQQKEGISACLQGSPFVTPKRQYKPVPD AKAP3_HUMAN AKAP3_HUMAN EPKSEEETC-----AKTLGEHIIKEGLTLWHKSQQKECKSLGFQHAAFEAPNTQRKPASD B3KQD0_HUMAN B3KQD0_HUMAN EPKSEEETC-----AKTLGEHIIKEGLTLWHKSQQKECKSLGFQHAAFEAPNTQRKPASD MATCH . : * .: :.***:**.* :* :.:* . CONSENSUS ????????C?????AE???EHI?KE?L??W????Q?????????????????????????

A8K8U8_HUMAN A8K8U8_HUMAN --------AC-------SNKDQKGEKINASTDSLAKDLIVSALKLIQYHLTQQTKGKDTC AKAP4_HUMAN AKAP4_HUMAN --------AC-------SNKDEKGEKINASTDSLAKDLIVSALKLIQYHLTQQTKGKDTC Q9XS94_BOVIN Q9XS94_BOVIN --------TC-------PHKEEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKEAC Q925F9_MESAU Q925F9_MESAU -------KVC-------TTKDEKREKLSPSTDSLAKDLIVSALMLIQYHLTQQAKGKDIC A1L3T6_MOUSE A1L3T6_MOUSE V-------CC-------TSKDEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDPC AKAP4_MOUSE AKAP4_MOUSE V-------CC-------TSKDEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDPC AKAP4_RAT AKAP4_RAT --------VC-------PSKDEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDPC Q9Z263_MOUSE Q9Z263_MOUSE --------VC-------PSKDEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDPC Q66HC6_RAT Q66HC6_RAT VSFECP-DPCEVNPLQQPQPPENFENFMCESDSWAKDLIVSALLLIQYHLAQGGRMDAQS AKAP3_MOUSE AKAP3_MOUSE VSFECP-DPCEANPPHQPQPPENFANFMCDSDSWAKDLIVSALLLIQYHLAQGGKMDAQS Q497M9_MOUSE Q497M9_MOUSE VSFECP-DPCEANPPHQPQPPENFANFMCDSDSWAKDLIVSALLLIQYHLAQGGKMDAQS AKAP3_BOVIN AKAP3_BOVIN FPLGFPFDPCNFSLP--MQCPEKPENFMCDSDSWAKDLLVSALLLIQYHLAQGGNMDAQS AKAP3_HUMAN AKAP3_HUMAN ISFEYPEDIGNLSLP--PYPPEKPENFMYDSDSWAKDLIVSALLLIQYHLAQGGRRDARS B3KQD0_HUMAN B3KQD0_HUMAN ISFEYPEDIGNLSLP--PYPPEKPENFMYDSDSWAKDLIVSALLLIQYHLAQGGRRDARS MATCH :: :: .:** ****:**** ******:* . . . CONSENSUS ?????????C???????????E??E??????DS?AKDLIVSAL?LIQYHL?Q????????

A8K8U8_HUMAN A8K8U8_HUMAN EEDCPGSTMGYMAQSTQYEKCGGGQSAKALSVKQLESHRAPGPSTCQKENQHLDSQKMDM AKAP4_HUMAN AKAP4_HUMAN EEDCPGSTMGYMAQSTQYEKCGGGQSAKALSVKQLESHRAPGPSTCQKENQHLDSQKMDM Q9XS94_BOVIN Q9XS94_BOVIN EDDCPPGTTSYMTQSAQYEKCGGSQSAKALSMKHLETRGAPGPSTSMKDNQHLDSQKLDM Q925F9_MESAU Q925F9_MESAU EDECPGSSMGYMSQSTQYEKCGGSQNAKSLSMKHFESRGAPGPSACAKETQ-LDSHKLXM A1L3T6_MOUSE A1L3T6_MOUSE EEECPGSSMGYMSQSAQYEKCGGGQSSKSLSMKHFETRGAPGPSTCMKENQ-LESQKMDM AKAP4_MOUSE AKAP4_MOUSE EEECPGSSMGYMSQSAQYEKCGGGQSSKSLSMKHFETRGAPGPSTCMKENQ-LESQKMDM AKAP4_RAT AKAP4_RAT EEECPGSSMGYMSQSAQYEKSGGGQSSKSLSMKHFESRGAPGPSTCAKENQ-LESQKMDM Q9Z263_MOUSE Q9Z263_MOUSE EEECPGSSMGYMSQSAQYEKSGGGQSSKSLSMKHFESRGAPGPSTCAKENQ-LESQKMDM Q66HC6_RAT Q66HC6_RAT FLEAAASTNFP--------------TKSSPVVHDEGKVKSPPLKICEQE----QTEKKDL AKAP3_MOUSE AKAP3_MOUSE FLEAAASTNFPTNKP----------PPPSPVVQDECKLKSPPHKICDQE----QTEKKDL Q497M9_MOUSE Q497M9_MOUSE FLEAAASTNFPTNKP----------PPPSPVVQDECKLKSPPHKICDQE----QTEKKDL AKAP3_BOVIN AKAP3_BOVIN FLEAAGTSNLY--------------PTKSPAVSHESSLRSPQVG-ADPE----EVEKKDL AKAP3_HUMAN AKAP3_HUMAN FVEAAGTTNFP--------------ANEPPVAPDESCLKSAPIV-GDQE----QAEKKDL B3KQD0_HUMAN B3KQD0_HUMAN FVEAAGTTNFP--------------ANEPPVAPDESCLKSAPIV-GDQE----QAEKKDL MATCH :.. : . . :. : : .* : CONSENSUS ????????????????????????????????????????P???????E???????K?D?

A8K8U8_HUMAN A8K8U8_HUMAN SNIVLMLIQKLLNENPFKCEDPCEGENK-----------CSEPRASKAASMSNRSDKAEE AKAP4_HUMAN AKAP4_HUMAN SNIVLMLIQKLLNENPFKCEDPCEGENK-----------CSEPRASKAASMSNRSDKAEE Q9XS94_BOVIN Q9XS94_BOVIN SNMVLSLIQKLLNESPFNCEDLCEGENKH-----------SEIRTNKSTSIFKKSDREEE Q925F9_MESAU Q925F9_MESAU SNMVLSLIQKLLSESPFSCDDLPEGENKR-----------SDPRSSKTGPMAK---RPED A1L3T6_MOUSE A1L3T6_MOUSE SNMVLSLIQKLLSESPFSCDELTESDNKR----------CCDPRSSKAAPMAK---RPEE AKAP4_MOUSE AKAP4_MOUSE SNMVLSLIQKLLSESPFSCDELTESDNKR----------CCDPRSSKAAPMAK---RPEE AKAP4_RAT AKAP4_RAT SNMVLSLIQKLLSESPFSCDELSESENKR----------CCDSRSKQAAPVAK---RPED Q9Z263_MOUSE Q9Z263_MOUSE SNMVLSLIQKLLSESPFSCDELSESENKR----------CCDSRSKQAAPVAK---RPED Q66HC6_RAT Q66HC6_RAT MSVIFNFIRNLLSETIFKGSRNCESKAHEQIIKEEEINLCERPLSPCERPMSP---PVPK AKAP3_MOUSE AKAP3_MOUSE MSVIFNFIRNLLSETIFKSSRNCESNVHEQNTQEEEIHPCERPKTPCERPITP---PAPK Q497M9_MOUSE Q497M9_MOUSE MSVIFNFIRNLLSETIFKSSRNCESNVHEQNTQEEEIHPCERPKTPCERPITP---PAPK AKAP3_BOVIN AKAP3_BOVIN MSVFFNLIRNLLSETIFKSDHSCDPKATK-----------EDNSPQCERPVTP---SPAK AKAP3_HUMAN AKAP3_HUMAN RSVFFNFIRNLLSETIFKRDQSPEPKVPEQ--------PVKEDRKLCERPLAS---SPPR B3KQD0_HUMAN B3KQD0_HUMAN RSVFFNFIRNLLSETIFKRDQSPEPKVPEQ--------PVKEDRKLCERPLAS---SPPR MATCH .:.: :*::**.*. *. . : . .: CONSENSUS ???????I??LL?E??F??????E????????????????????????????????????

A8K8U8_HUMAN A8K8U8_HUMAN QCQEHQ-ELDCTSGMKQ---------ANGQFIDKLVESVMKLCLIMAKYSNDGAALAELE AKAP4_HUMAN AKAP4_HUMAN QCQEHQ-ELDCTSGMKQ---------ANGQFIDKLVESVMKLCLIMAKYSNDGAALAELE Q9XS94_BOVIN Q9XS94_BOVIN QGQDNR-EVDFVGGMKQ---------VNRQFIDQLVESVMKLCLIMAKYSNNEAALTDLE Q925F9_MESAU Q925F9_MESAU QCPDSS-EQDFISGMKQ---------MNRQFIDQLVESVMKLCLIMAKYSNNGAALAELE A1L3T6_MOUSE A1L3T6_MOUSE QCQDNA-ELDFISGMKQ---------MNRQFIDQLVESVMKLCLIMAKYSNNGAALAELE AKAP4_MOUSE AKAP4_MOUSE QCQDNA-ELDFISGMKQ---------MNRQFIDQLVESVMKLCLIMAKYSNNGAALAELE AKAP4_RAT AKAP4_RAT QSQDST-EMDFISGMKQ---------MNRQFIDQLVESVMKLCLIMAKYSNNGAALAELE Q9Z263_MOUSE Q9Z263_MOUSE QSQDST-EMDFISGMKQ---------MNRQFIDQLVESVMKLCLIMAKYSNNGAALAELE Q66HC6_RAT Q66HC6_RAT FCEDEEATGGALSGLTKMVANQLDGCMNGQMVEHLMDSVMKLCLIIAKSCD--SPLSELG AKAP3_MOUSE AKAP3_MOUSE FCEDEEATGGALSGLTKMVANQLDNCMNGQMVEHLMDSVMKLCLIIAKSCD--SPLSELG Q497M9_MOUSE Q497M9_MOUSE FCEDEEATGGALSGLTKMVANQLDNCMNGQMVEHLMDSVMKLCLIIAKSCD--SPLSELG AKAP3_BOVIN AKAP3_BOVIN LNECDE-TGGAFAGLTKMVANKLDGHMNGQMVDHLMDSVMKLCLIIAKSCD--SPLAELG AKAP3_HUMAN AKAP3_HUMAN LYEDDE-TPGALSGLTKMAVSQIDGHMSGQMVEHLMNSVMKLCVIIAKSCD--ASLAELG B3KQD0_HUMAN B3KQD0_HUMAN LYEDDE-TPGALSGLTKMAVSQIDGHMSGQMVEHLMNSVMKLCVIIAKSCD--ASLAELG MATCH . .*:.: . *::::*::******:*:** .: :.*::* CONSENSUS ????????????SG?????????????N?Q????L??SVMKLCLI?AK???????L?EL?

A8K8U8_HUMAN A8K8U8_HUMAN EQ---------AASANKPNFR---GTRCIHSGAMPQNYQDSLG---------------HE AKAP4_HUMAN AKAP4_HUMAN EQ---------AASANKPNFR---GTRCIHSGAMPQNYQDSLG---------------HE Q9XS94_BOVIN Q9XS94_BOVIN EQ---------ASSSNNSNFYQTSGPRSSYEAGMSQSYQDSHG---------------PE Q925F9_MESAU Q925F9_MESAU EQ---------AAMAGG-------SSRCGREGAMSQ-YQDAPG---------------PE A1L3T6_MOUSE A1L3T6_MOUSE EQ---------AALVGS-------GSRCGRDAMMSQNYSETPG---------------PE AKAP4_MOUSE AKAP4_MOUSE EQ---------AALVGS-------GSRCGRDAMMSQNYSETPG---------------PE AKAP4_RAT AKAP4_RAT EQ---------AALASN-------GPRCGREAVMSQSYLETPG---------------PE Q9Z263_MOUSE Q9Z263_MOUSE EQ---------AALASN-------GPRCGREAVMSQSYPETPG---------------PE Q66HC6_RAT Q66HC6_RAT DEKCGDASRPSSAFPDNLYECLPVKGTGTAEALLQNAYLAIHNELRGLSGQPPEGCEIPK AKAP3_MOUSE AKAP3_MOUSE EEKCGDASRPNSAFPDNLYECLPVKGTGTAEALLQNAYLTIHNELRGLSGQPPEGCEIPK Q497M9_MOUSE Q497M9_MOUSE EEKCGDASRPNSAFPDNLYECLPVKGTGTAEALLQNAYLTIHNELRGLSGQPPEGCEIPK AKAP3_BOVIN AKAP3_BOVIN DDKSGDASRPTSAFPESLYECLSTKGTGTAETLLQNAYQAIHNELRSLSAQPPEGCTAPK AKAP3_HUMAN AKAP3_HUMAN DDKSGDASRLTSAFPDSLYECLPAKGTGSAEAVLQNAYQAIHNEMRGTSGQPPEGCAAPT B3KQD0_HUMAN B3KQD0_HUMAN DDKSGDASRLTSAFPDSLYECLPAKGTGSAEAVLQNAYQAIHNEMRGTSGQPPEGCAAPT MATCH :: :: . : : * . CONSENSUS ????????????A????????????????????????Y????????????????????P?

A8K8U8_HUMAN A8K8U8_HUMAN VIVNNQCSTNSLQ-KQLQAVLQWIAASQFNVPMLYFMGDKDGQLEKLPQVSAKAAEKGYS AKAP4_HUMAN AKAP4_HUMAN VIVNNQCSTNSLQ-KQLQAVLQWIAASQFNVPMLYFMGDKDGQLEKLPQVSAKAAEKGYS Q9XS94_BOVIN Q9XS94_BOVIN VIVNNQCSTSSLQ-KQLQAVLQWIAASQFNVPMLYFMGDDDGQLEKLPEVSAKAAEKGYS Q925F9_MESAU Q925F9_MESAU VIVNNQCSTSNLQ-KQLQAVLQWIAASQFNVPMLYFMGDDDGQLEKLPEVSAKAAEKGYS A1L3T6_MOUSE A1L3T6_MOUSE VIVNNQCSTTNLQ-KQLQAVLQWIAASQFNVPMLYFMGDDDGQLEKLPEVSAKAAEKGYS AKAP4_MOUSE AKAP4_MOUSE VIVNNQCSTTNLQ-KQLQAVLQWIAASQFNVPMLYFMGDDDGQLEKLPEVSAKAAEKGYS AKAP4_RAT AKAP4_RAT VIVNNQCSTSNLQ-KQLQAVLQWIAASQFNVPMLYFMGDDDGQLEKLPEVSAKAAEKGYS Q9Z263_MOUSE Q9Z263_MOUSE VIVNNQCSTSNLQ-KQLQAVLQWIAASQFNVPMLYFMGDDDGQLEKLPEVSAKAAEKGYS Q66HC6_RAT Q66HC6_RAT VIVSNHNLADTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSATAVEKGRS AKAP3_MOUSE AKAP3_MOUSE VIVSNHNLADTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSATAVEKGRS Q497M9_MOUSE Q497M9_MOUSE VIVSNHNLADTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSATAVEKGRS AKAP3_BOVIN AKAP3_BOVIN VIVSNHNLTDTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSAAAVEKGRS AKAP3_HUMAN AKAP3_HUMAN VIVSNHNLTDTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSAAAVDKGCS B3KQD0_HUMAN B3KQD0_HUMAN VIVSNHNLTDTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSAAAVDKGCS MATCH ***.*: : .:* *********:***::***:*** **.:* *** ::** *.:** * CONSENSUS VIV?N???????Q?KQLQAVLQW?AAS??NVP?LYF?GDD?G??EKL???SA?A?EKG?S

A8K8U8_HUMAN A8K8U8_HUMAN VGGLLQEVMKFAKERQPDEAVGKVARKQLLDWLLANL AKAP4_HUMAN AKAP4_HUMAN VGGLLQEVMKFAKERQPDEAVGKVARKQLLDWLLANL Q9XS94_BOVIN Q9XS94_BOVIN VGDLLQEVMKFAKERQLDEAVGNMARKQLLDWLLGNL Q925F9_MESAU Q925F9_MESAU VGDLLQEVMKFAKERQMDEA----------------- A1L3T6_MOUSE A1L3T6_MOUSE VGDLLQEVMKFAKERQLDEAVGNMARKQLLDWLLANL AKAP4_MOUSE AKAP4_MOUSE VGDLLQEVMKFAKERQLDEAVGNMARKQLLDWLLANL AKAP4_RAT AKAP4_RAT VGDLLQEVMKFAKERQLDEAVGNMARKQLLDWLLANL Q9Z263_MOUSE Q9Z263_MOUSE VGDLLQEVMKFAKETQLDEAVGNMARKQLLDWLLANL Q66HC6_RAT Q66HC6_RAT VGEVLQSVLRYEKERQLDEAVGNVTRLQLLDWLMANL AKAP3_MOUSE AKAP3_MOUSE VGEVLQSVLRYEKERQLDEAVGNVTRLQLLDWLMANL Q497M9_MOUSE Q497M9_MOUSE VGEVLQSVLRYEKERQLDEAVGNVTRLQLLDWLMANL AKAP3_BOVIN AKAP3_BOVIN VGEVLQSVLRYEKERQLDEAVGNVTRLQLLDWLMVNL AKAP3_HUMAN AKAP3_HUMAN VGEVLQSVLRYEKERQLNEAVGNVTPLQLLDWLMVNL B3KQD0_HUMAN B3KQD0_HUMAN VGEVLQSVLRYEKERQLNEAVGNVTPLQLLDWLMVNL MATCH ** :**.*::: ** * :** CONSENSUS VG??LQ?V????KERQ?DEAVG?????QLLDWL??NL


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