Alignment of the gene Family HBG050616 of HOVERGEN

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Isoforms are ON
Q4SDE7_TETNG Q4SDE7_TETNG -------------------------MREKSMSESPSQAGKEIPVKKQKLSSDENSNPDLS B1AQ57_MOUSE B1AQ57_MOUSE -------------------------------------------------------MP--- ATP7B_MOUSE ATP7B_MOUSE --------------------------------MDPRKNLASVGT-----------MP--- B1AQ56_MOUSE B1AQ56_MOUSE --------------------------------MDPRKNLASVGT-----------MP--- ATP7B_RAT ATP7B_RAT -------------------------------------------------------MP--- Q9QUG4_RAT Q9QUG4_RAT -------------------------------------------------------MP--- Q9R0T2_RAT Q9R0T2_RAT -------------------------------------------------------MP--- B0EVF7_CANFA B0EVF7_CANFA ------------------------------------------------------------ Q4U3G5_CANFA Q4U3G5_CANFA ------------------------------------------------------------ B7ZLR2_HUMAN B7ZLR2_HUMAN -------------------------------------------------------MP--- B7ZLR3_HUMAN B7ZLR3_HUMAN -------------------------------------------------------MP--- B7ZLR4_HUMAN B7ZLR4_HUMAN -------------------------------------------------------MP--- ATP7B_HUMAN ATP7B_HUMAN -------------------------------------------------------MP--- Q17RT3_HUMAN Q17RT3_HUMAN -------------------------------------------------------MP--- ATP7B_SHEEP ATP7B_SHEEP ERAGDQAPGNPEPSSLATLGDPQVTLLTVHKRWSFKRSPGTGGSSRPVISEEECPPP--- A5A789_PIG A5A789_PIG ------------------------------------------------------------ A5A788_PIG A5A788_PIG ------------------------------------------------------------ ATP7A_HUMAN ATP7A_HUMAN --------------------------------MDPSMGVNSVTISVEGMTCNSCVWT--- ATP7A_CRIGR ATP7A_CRIGR --------------------------------MEPSMDVNSVTISVEGMTCISCVRT--- ATP7A_RAT ATP7A_RAT --------------------------------MEPNMDANSITITVEGMTCISCVRT--- ATP7A_MOUSE ATP7A_MOUSE --------------------------------MEPSVDANSITITVEGMTCISCVRT--- B9EJ97_MOUSE B9EJ97_MOUSE --------------------------------MEPSVDANSITITVEGMTCISCVRT--- A2AG68_MOUSE A2AG68_MOUSE --------------------------------MEPSVDANSITITVEGMTCISCVRT--- A2AG69_MOUSE A2AG69_MOUSE --------------------------------MEPSVDANSITITVEGMTCISCVRT--- Q4F8H5_DANRE Q4F8H5_DANRE --------------------------------MALSTNLCRVTLGVEGMTCGSCVQS--- Q4SJX4_TETNG Q4SJX4_TETNG ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4SDE7_TETNG Q4SDE7_TETNG GDENDDAVSVESGTNTERPDTPTNTANAPGRKSWGKGKWKSKKCRYSFKCVNSLREDHSQ B1AQ57_MOUSE B1AQ57_MOUSE -------EQERQVTAKE-ASRKILSKLALPGRPWEQSMKQSF----AFD----------- ATP7B_MOUSE ATP7B_MOUSE -------EQERQVTAKE-ASRKILSKLALPGRPWEQSMKQSF----AFD----------- B1AQ56_MOUSE B1AQ56_MOUSE -------EQERQVTAKE-ASRKILSKLALPGRPWEQSMKQSF----AFD----------- ATP7B_RAT ATP7B_RAT -------EQERKVTAKE-ASRKILSKLALPTRPWGQSMKQSF----AFD----------- Q9QUG4_RAT Q9QUG4_RAT -------EQERKVTAKE-ASRKILSKLALPTRPWGQSMKQSF----AFD----------- Q9R0T2_RAT Q9R0T2_RAT -------EQERKVTAKE-ASRKILSKLALPTRPWGQSMKQSF----AFD----------- B0EVF7_CANFA B0EVF7_CANFA ----------------------ILSKLSLPTRAWEPVMKQSF----AFD----------- Q4U3G5_CANFA Q4U3G5_CANFA -------------------------------------MKQSF----AFD----------- B7ZLR2_HUMAN B7ZLR2_HUMAN -------EQERQITAREGASRKILSKLSLPTRAWEPAMKKSF----AFD----------- B7ZLR3_HUMAN B7ZLR3_HUMAN -------EQERQITAREGASRKILSKLSLPTRAWEPAMKKSF----AFD----------- B7ZLR4_HUMAN B7ZLR4_HUMAN -------EQERQITAREGASRKILSKLSLPTRAWEPAMKKSF----AFD----------- ATP7B_HUMAN ATP7B_HUMAN -------EQERQITAREGASRKILSKLSLPTRAWEPAMKKSF----AFD----------- Q17RT3_HUMAN Q17RT3_HUMAN -------EQERQITAREGASRKILSKLSLPTRAWEPAMKKSF----AFD----------- ATP7B_SHEEP ATP7B_SHEEP -------SEEGEFSQKVLNGSEEISSKQILSKLFQPAMKQSF----AFD----------- A5A789_PIG A5A789_PIG ------------------------------------------------------------ A5A788_PIG A5A788_PIG ------------------------------------------------------------ ATP7A_HUMAN ATP7A_HUMAN -------IEQQIGKVNGVHHIKVSLEEKNATIIYDPKLQTPKTLQEAID----------- ATP7A_CRIGR ATP7A_CRIGR -------IEQKIGKENGIHHIKVSLEEKSATIIYDPKLQTPKTLQEAID----------- ATP7A_RAT ATP7A_RAT -------IEQQIGKVNGVHHIKVSLEEKSATVIYNPKLQTPKTLQEAID----------- ATP7A_MOUSE ATP7A_MOUSE -------IEQQIGKVNGVHHIKVSLDEKSATIIYDPKLQTPKTLQEAID----------- B9EJ97_MOUSE B9EJ97_MOUSE -------IEQQIGKVNGVHHIKVSLEEKSATIIYDPKLQTPKTLQEAID----------- A2AG68_MOUSE A2AG68_MOUSE -------IEQQIGKVNGVHHIKVSLEEKSATIIYDPKLQTPKTLQEAID----------- A2AG69_MOUSE A2AG69_MOUSE -------IEQQIGKVNGVHHIKVSLEEKSATIIYDPKLQTPKTLQEAID----------- Q4F8H5_DANRE Q4F8H5_DANRE -------IEGRIGGLPGVIHIQVSLEQNNATVTYDHTQHTPQSIADAIE----------- Q4SJX4_TETNG Q4SJX4_TETNG ------------------------------------------------------------ MATCH CONSENSUS ??????????????????????????????????????????????A?D???????????

Q4SDE7_TETNG Q4SDE7_TETNG PLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADASPVVTQFDLTR B1AQ57_MOUSE B1AQ57_MOUSE ---NVGYEGGLDSTSS-SPAATDVVNILGMTCHS-------------------------- ATP7B_MOUSE ATP7B_MOUSE ---NVGYEGGLDSTSS-SPAATDVVNILGMTCHS-------------------------- B1AQ56_MOUSE B1AQ56_MOUSE ---NVGYEGGLDSTSS-SPAATDVVNILGMTCHS-------------------------- ATP7B_RAT ATP7B_RAT ---NVGYEGGLDSTCFILQLTTGVVSILGMTCHS-------------------------- Q9QUG4_RAT Q9QUG4_RAT ---NVGYEGGLDSTCS-SSTTTGVVSILGMTCHS-------------------------- Q9R0T2_RAT Q9R0T2_RAT ---NVGYEGGLDSTCS-SSTTTGVVSILGMTCHS-------------------------- B0EVF7_CANFA B0EVF7_CANFA ---NVGYEGGLDSVCP-PQTATSTISILGMTCQS-------------------------- Q4U3G5_CANFA Q4U3G5_CANFA ---NVGYEGGLDSVCP-PQTATSTISILGMTCQS-------------------------- B7ZLR2_HUMAN B7ZLR2_HUMAN ---NVGYEGGLDGLGPSSQVATSTVRILGMTCQS-------------------------- B7ZLR3_HUMAN B7ZLR3_HUMAN ---NVGYEGGLDGLGPSSQVATSTVRILGMTCQS-------------------------- B7ZLR4_HUMAN B7ZLR4_HUMAN ---NVGYEGGLDGLGPSSQVATSTVRILGMTCQS-------------------------- ATP7B_HUMAN ATP7B_HUMAN ---NVGYEGGLDGLGPSSQVATSTVRILGMTCQS-------------------------- Q17RT3_HUMAN Q17RT3_HUMAN ---NVGYEGGLDGLGPSSQVATSTVRILGMTCQS-------------------------- ATP7B_SHEEP ATP7B_SHEEP ---NNGYEDDLDGVCP-SQTAAGTISIVGMTCQS-------------------------- A5A789_PIG A5A789_PIG ---NSGYEEGLDGVCP-SQTASGTIRVGGMTCQS-------------------------- A5A788_PIG A5A788_PIG ------------------------------------------------------------ ATP7A_HUMAN ATP7A_HUMAN ---DMGFDAVIHNPDP-LPVLTDTLFLTVTASLT-------------------------- ATP7A_CRIGR ATP7A_CRIGR ---DMGFDALLHNANP-LPVLTDTLFLTVTASLT-------------------------- ATP7A_RAT ATP7A_RAT ---DMGFDALLHNANP-LPVLTNTVFLTVTAPLA-------------------------- ATP7A_MOUSE ATP7A_MOUSE ---DMGFDALLHNANP-LPVLTNTVFLTVTAPLT-------------------------- B9EJ97_MOUSE B9EJ97_MOUSE ---DMGFDALLHNANP-LPVLTNTVFLTVTAPLT-------------------------- A2AG68_MOUSE A2AG68_MOUSE ---DMGFDALLHNANP-LPVLTNTVFLTVTAPLT-------------------------- A2AG69_MOUSE A2AG69_MOUSE ---DMGFDALLHNANP-LPVLTNTVFLTVTAPLT-------------------------- Q4F8H5_DANRE Q4F8H5_DANRE ---DMGFESSLTNATS-TPVQTETKVFSKAGCSA-------------------------- Q4SJX4_TETNG Q4SJX4_TETNG ----MGFESTLSETTPVAAVSVDTQVIPTPNLEA-------------------------- MATCH CONSENSUS ?????G????L??????????T??????????????????????????????????????

Q4SDE7_TETNG Q4SDE7_TETNG RAQADENFYTCAWTYDTNTSHPLLAVAGSRGIIRIINHISMQCIKHYVGHGNAINELKFH B1AQ57_MOUSE B1AQ57_MOUSE ---------------------------------------CVKSIEDRISSLKGIVNIKVS ATP7B_MOUSE ATP7B_MOUSE ---------------------------------------CVKSIEDRISSLKGIVNIKVS B1AQ56_MOUSE B1AQ56_MOUSE ---------------------------------------CVKSIEDRISSLKGIVNIKVS ATP7B_RAT ATP7B_RAT ---------------------------------------CVKSIEDRISSLKGIVSIKVS Q9QUG4_RAT Q9QUG4_RAT ---------------------------------------CVKSIEDRISSLKGIVSIKVS Q9R0T2_RAT Q9R0T2_RAT ---------------------------------------CVKSIEDRISSLKGIVSIKVS B0EVF7_CANFA B0EVF7_CANFA ---------------------------------------CVRSIEGRISSLKGIVSIKIS Q4U3G5_CANFA Q4U3G5_CANFA ---------------------------------------CVRSIEGRISSLKGIVSIKIS B7ZLR2_HUMAN B7ZLR2_HUMAN ---------------------------------------CVKSIEDRISNLKGIISMKVS B7ZLR3_HUMAN B7ZLR3_HUMAN ---------------------------------------CVKSIEDRISNLKGIISMKVS B7ZLR4_HUMAN B7ZLR4_HUMAN ---------------------------------------CVKSIEDRISNLKGIISMKVS ATP7B_HUMAN ATP7B_HUMAN ---------------------------------------CVKSIEDRISNLKGIISMKVS Q17RT3_HUMAN Q17RT3_HUMAN ---------------------------------------CVKSIEDRISNLKGIISMKVS ATP7B_SHEEP ATP7B_SHEEP ---------------------------------------CVKSIEGRVSSLKGIVSIKVS A5A789_PIG A5A789_PIG ---------------------------------------CVKSIEGRVSSLKGILSVTVS A5A788_PIG A5A788_PIG ------------------------------------------------------------ ATP7A_HUMAN ATP7A_HUMAN --------------------------------------LPWDHIQSTLLKTKGVTDIKIY ATP7A_CRIGR ATP7A_CRIGR --------------------------------------LPWDHIQSTLLKTKGVTDIKIF ATP7A_RAT ATP7A_RAT --------------------------------------LPWDHIQSTLLKTKGVTGVKIS ATP7A_MOUSE ATP7A_MOUSE --------------------------------------LPWDHVQSTLLKTKGVTGVKIS B9EJ97_MOUSE B9EJ97_MOUSE --------------------------------------LPWDHIQSTLLKTKGVTGVKIS A2AG68_MOUSE A2AG68_MOUSE --------------------------------------LPWDHIQSTLLKTKGVTGVKIS A2AG69_MOUSE A2AG69_MOUSE --------------------------------------LPWDHIQSTLLKTKGVTGVKIS Q4F8H5_DANRE Q4F8H5_DANRE --------------------------------------DSVQQALSTLAQIKGVIETQES Q4SJX4_TETNG Q4SJX4_TETNG --------------------------------------AAQQEALQKLAQIHGVLDVREG MATCH CONSENSUS ???????????????????????????????????????????I???????KG????K?S

Q4SDE7_TETNG Q4SDE7_TETNG PRDPNLLLSVSKDHALRLWNIRTDTLVAIFGGVEGHRDEVLSADFDLLGEKIMSCGMDHS B1AQ57_MOUSE B1AQ57_MOUSE LEQGSATVR--------------------------------------------------- ATP7B_MOUSE ATP7B_MOUSE LEQGKHTVR--------------------------------------------------- B1AQ56_MOUSE B1AQ56_MOUSE LEQGSATVR--------------------------------------------------- ATP7B_RAT ATP7B_RAT LEQGSATVK--------------------------------------------------- Q9QUG4_RAT Q9QUG4_RAT LEQGSATVK--------------------------------------------------- Q9R0T2_RAT Q9R0T2_RAT LEQGSATVK--------------------------------------------------- B0EVF7_CANFA B0EVF7_CANFA LEQGNATVK--------------------------------------------------- Q4U3G5_CANFA Q4U3G5_CANFA LEQGNATVK--------------------------------------------------- B7ZLR2_HUMAN B7ZLR2_HUMAN LEQGSATVK--------------------------------------------------- B7ZLR3_HUMAN B7ZLR3_HUMAN LEQGSATVK--------------------------------------------------- B7ZLR4_HUMAN B7ZLR4_HUMAN LEQGSATVK--------------------------------------------------- ATP7B_HUMAN ATP7B_HUMAN LEQGSATVK--------------------------------------------------- Q17RT3_HUMAN Q17RT3_HUMAN LEQGSATVK--------------------------------------------------- ATP7B_SHEEP ATP7B_SHEEP LEQSSAEVR--------------------------------------------------- A5A789_PIG A5A789_PIG LEQGSAAVR--------------------------------------------------- A5A788_PIG A5A788_PIG ------------------------------------------------------------ ATP7A_HUMAN ATP7A_HUMAN PQKRTVAVT--------------------------------------------------- ATP7A_CRIGR ATP7A_CRIGR PQKRTLAVT--------------------------------------------------- ATP7A_RAT ATP7A_RAT PQQRSAVVT--------------------------------------------------- ATP7A_MOUSE ATP7A_MOUSE PQQRSAVVT--------------------------------------------------- B9EJ97_MOUSE B9EJ97_MOUSE PQQRSAVVT--------------------------------------------------- A2AG68_MOUSE A2AG68_MOUSE PQQRSAVVT--------------------------------------------------- A2AG69_MOUSE A2AG69_MOUSE PQQRSAVVT--------------------------------------------------- Q4F8H5_DANRE Q4F8H5_DANRE ADNQGLAVT--------------------------------------------------- Q4SJX4_TETNG Q4SJX4_TETNG PAGTGLSVT--------------------------------------------------- MATCH CONSENSUS ???????V????????????????????????????????????????????????????

Q4SDE7_TETNG Q4SDE7_TETNG LKLWRIDSERMQNAIRGSYEYNPSKTNRPFVSQKI--HFPDFSTRDIHRNYVDCVRWLGD B1AQ57_MOUSE B1AQ57_MOUSE --------------------YVPSVMNLQQICLQI----EDMG----------------- ATP7B_MOUSE ATP7B_MOUSE --------------------YVPSVMNLQQICLQI----EDMG----------------- B1AQ56_MOUSE B1AQ56_MOUSE --------------------YVPSVMNLQQICLQI----EDMG----------------- ATP7B_RAT ATP7B_RAT --------------------YVPSVLNLQQICLQI----EDMG----------------- Q9QUG4_RAT Q9QUG4_RAT --------------------YVPSVLNLQQICLQI----EDMG----------------- Q9R0T2_RAT Q9R0T2_RAT --------------------YVPSVLNLQQICLQI----EDMG----------------- B0EVF7_CANFA B0EVF7_CANFA --------------------YMPSILSLPQVCRHI----EDMG----------------- Q4U3G5_CANFA Q4U3G5_CANFA --------------------YMPSILSLPQVCRHI----EDMG----------------- B7ZLR2_HUMAN B7ZLR2_HUMAN --------------------YVPSVVCLQQVCHQI----GDMG----------------- B7ZLR3_HUMAN B7ZLR3_HUMAN --------------------YVPSVVCLQQVCHQI----GDMG----------------- B7ZLR4_HUMAN B7ZLR4_HUMAN --------------------YVPSVVCLQQVCHQI----GDMG----------------- ATP7B_HUMAN ATP7B_HUMAN --------------------YVPSVVCLQQVCHQI----GDMG----------------- Q17RT3_HUMAN Q17RT3_HUMAN --------------------YVPSVVCLQQVCHQI----GDMG----------------- ATP7B_SHEEP ATP7B_SHEEP --------------------YVPSVVSLMQICHQI----EDMG----------------- A5A789_PIG A5A789_PIG --------------------YVPSVLSLPQVCRQI----EDMG----------------- A5A788_PIG A5A788_PIG ------------------------------------------------------------ ATP7A_HUMAN ATP7A_HUMAN --------------------IIPSIVNANQIKELV----PELS----------------- ATP7A_CRIGR ATP7A_CRIGR --------------------IIPSIVNANQIKELV----PELS----------------- ATP7A_RAT ATP7A_RAT --------------------IIPSVVSANQIVELV----PDLS----------------- ATP7A_MOUSE ATP7A_MOUSE --------------------IIPSVVSASQIVELV----PDLS----------------- B9EJ97_MOUSE B9EJ97_MOUSE --------------------IIPSVVSASQIVELV----PDLS----------------- A2AG68_MOUSE A2AG68_MOUSE --------------------IIPSVVSASQIVELV----PDLS----------------- A2AG69_MOUSE A2AG69_MOUSE --------------------IIPSVVSASQIVELV----PDLS----------------- Q4F8H5_DANRE Q4F8H5_DANRE --------------------FVPSLVSEDQLGEVL----KCLA----------------- Q4SJX4_TETNG Q4SJX4_TETNG --------------------FVPSLTTSLQLNEAVASWIPESP----------------- MATCH CONSENSUS ??????????????????????PS?????Q??????????D???????????????????

Q4SDE7_TETNG Q4SDE7_TETNG LILSKSCENAIVCWKPGKMEDDVDHIKANESNVTILGRFDYSQCDIWYMRFSMDFWQKML B1AQ57_MOUSE B1AQ57_MOUSE -FEASAAEGKAASWP--------SRSSP-AQEAVVKLRVEGMTCQ-----------SCVS ATP7B_MOUSE ATP7B_MOUSE -FEASAAEGKAASWP--------SRSSP-AQEAVVKLRVEGMTCQ-----------SCVS B1AQ56_MOUSE B1AQ56_MOUSE -FEASAAEGKAASWP--------SRSSP-AQEAVVKLRVEGMTCQ-----------SCVS ATP7B_RAT ATP7B_RAT -FEASAAEGKAASWP--------SRSSP-AQEAVVKLRVEGMTCQ-----------SCVS Q9QUG4_RAT Q9QUG4_RAT -FEASAAEGKAASWP--------SRSSP-AQEAVVKLRVEGMTCQ-----------SCVS Q9R0T2_RAT Q9R0T2_RAT -FEASAAEGKAASWP--------SRSSP-AQEAVVKLRVEGMTCQ-----------SCVS B0EVF7_CANFA B0EVF7_CANFA -FEASVAEGKAASWP--------SRSSP-GLEAVVRLRVEGMTCQ-----------SCVS Q4U3G5_CANFA Q4U3G5_CANFA -FEASVAEGKAASWP--------SRSSP-GLEAVVRLRVEGMTCQ-----------SCVS B7ZLR2_HUMAN B7ZLR2_HUMAN -FEASIAEGKAASWP--------SRSLP-AQEAVVKLRVEGMTCQ-----------SCVS B7ZLR3_HUMAN B7ZLR3_HUMAN -FEASIAEGKAASWP--------SRSLP-AQEAVVKLRVEGMTCQ-----------SCVS B7ZLR4_HUMAN B7ZLR4_HUMAN -FEASIAEGKAASWP--------SRSLP-AQEAVVKLRVEGMTCQ-----------SCVS ATP7B_HUMAN ATP7B_HUMAN -FEASIAEGKAASWP--------SRSLP-AQEAVVKLRVEGMTCQ-----------SCVS Q17RT3_HUMAN Q17RT3_HUMAN -FEASIAEGKAASWP--------SRSLP-AQEAVVKLRVEGMTCQ-----------SCVS ATP7B_SHEEP ATP7B_SHEEP -FQASVAEGKATSWA--------SRVSP-TSEAVVKLRVEGMTCQ-----------SCVS A5A789_PIG A5A789_PIG -FEASVEEGKAASWP--------SRVSP-APEAVVKLRVEGMTCQ-----------SCVS A5A788_PIG A5A788_PIG ------------------------------------------------------------ ATP7A_HUMAN ATP7A_HUMAN -LDTGTLEKKSGACE--------DHSMAQAGEVVLKMKVEGMTCH-----------SCTS ATP7A_CRIGR ATP7A_CRIGR -LETGTLEKRSGACE--------DHSMAQAGEVVLKIKVEGMTCH-----------SCTS ATP7A_RAT ATP7A_RAT -LDMGTQEKKSGTSE--------EHSTPQAGEVLLKMRVEGMTCH-----------SCTS ATP7A_MOUSE ATP7A_MOUSE -LDMGTQEKKSGACE--------EHSTPQAGEVRLKMKVEGMTCH-----------SCTS B9EJ97_MOUSE B9EJ97_MOUSE -LDMGTQEKKSGACE--------EHSTPQAGEVMLKMKVEGMTCH-----------SCTS A2AG68_MOUSE A2AG68_MOUSE -LDMGTQEKKSGACE--------EHSTPQAGEVMLKMKVEGMTCH-----------SCTS A2AG69_MOUSE A2AG69_MOUSE -LDMGTQEKKSGACE--------EHSTPQAGEVMLKMKVEGMTCH-----------SCTS Q4F8H5_DANRE Q4F8H5_DANRE -PDTACRPPLSPKEG--------STSRSFSGVEAVKMRIEGMVCL-----------SCTT Q4SJX4_TETNG Q4SJX4_TETNG -APGSPKHEAPGSSP--------SHTVV-GGVSLLKLCIEGMTCH-----------SCTT MATCH CONSENSUS ???????E?K???????????????S?????E???K??VEGMTC????????????SC?S

Q4SDE7_TETNG Q4SDE7_TETNG ALGNQVGKLYVWDLEVEDPHKAKCTTLTLPKCTAAIRQTSFSRDSSILIAD--HAELQTL B1AQ57_MOUSE B1AQ57_MOUSE SIEGKIRKL---------------QGVVRIKVSLSNQEAVITYQPYLIQPEDLRDHICDM ATP7B_MOUSE ATP7B_MOUSE SIEGKIRKL---------------QGVVRIKVSLSNQEAVITYQPYLIQPEDLRDHICDM B1AQ56_MOUSE B1AQ56_MOUSE SIEGKIRKL---------------QGVVRIKVSLSNQEAVITYQPYLIQPEDLRDHICDM ATP7B_RAT ATP7B_RAT SIEGKIRKL---------------QGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHICDM Q9QUG4_RAT Q9QUG4_RAT SIEGKIRKL---------------QGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHICDM Q9R0T2_RAT Q9R0T2_RAT SIEGKIRKL---------------QGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHICDM B0EVF7_CANFA B0EVF7_CANFA SIEGKLGKL---------------QGVARVRVSLSTQEAVITYQPYLIQPQDLRDHVNDM Q4U3G5_CANFA Q4U3G5_CANFA SIEGKLGKL---------------QGVARVRVSLSTQEAVITYQPYLIQPQDLRDHVNDM B7ZLR2_HUMAN B7ZLR2_HUMAN SIEGKVRKL---------------QGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDM B7ZLR3_HUMAN B7ZLR3_HUMAN SIEGKVRKL---------------QGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDM B7ZLR4_HUMAN B7ZLR4_HUMAN SIEGKVRKL---------------QGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDM ATP7B_HUMAN ATP7B_HUMAN SIEGKVRKL---------------QGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDM Q17RT3_HUMAN Q17RT3_HUMAN SIEGKVRKL---------------QGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDM ATP7B_SHEEP ATP7B_SHEEP SIEGKIGKL---------------QGVMRVRVSLSNQEAVITYQPYLIQPQDLRDHITDM A5A789_PIG A5A789_PIG SIEGRLRKL---------------QGVVRVRVSLGNQEAVITYQPYLIQPQDLREHVNDM A5A788_PIG A5A788_PIG ----------------------------------------IIYQPHLITVEEIKKQIEAV ATP7A_HUMAN ATP7A_HUMAN TIEGKIGKL---------------QGVQRIKVSLDNQEATIVYQPHLISVEEMKKQIEAM ATP7A_CRIGR ATP7A_CRIGR TTEGKIGKL---------------QGVQRIKVSLDNQEATIVYQPHLISVEEIKKQIEAM ATP7A_RAT ATP7A_RAT TIEGKVGKL---------------QGVQRIKVSLDNQEATIVYQPHLITAEEIKKQIEAV ATP7A_MOUSE ATP7A_MOUSE TIEGKVGKL---------------QGVQRIKVSLDNQEATIVFQPHLITAEEIKKQIEAV B9EJ97_MOUSE B9EJ97_MOUSE TIEGKVGKL---------------QGVQRIKVSLDNQEATIVFQPHLITAEEIKKQIEAV A2AG68_MOUSE A2AG68_MOUSE TIEGKVGKL---------------QGVQRIKVSLDNQEATIVFQPHLITAEEIKKQIEAV A2AG69_MOUSE A2AG69_MOUSE TIEGKVGKL---------------QGVQRIKVSLDNQEATIVFQPHLITAEEIKKQIEAV Q4F8H5_DANRE Q4F8H5_DANRE TIEGKIGKL---------------KGVEKIKVSLESQEAAVVYLPYIITVDEIVKQIEVA Q4SJX4_TETNG Q4SJX4_TETNG TIEGKIGKL---------------KGIEKIKVVLETQEATLVYLPHLITVQTITDQIAVA MATCH . . :: : .: CONSENSUS ?IEGK??KL???????????????QGV?R?KVSL??QEA?I?YQP?LI????????????

Q4SDE7_TETNG Q4SDE7_TETNG GFDNLAYERGSQSELRPLAQPASRATFRLPGLGPEPSAEAVGSKFSGLAGVLSVFCPSKH B1AQ57_MOUSE B1AQ57_MOUSE GFEAAIKNRTAPLRLGPIDVNKLESTN---LKKETVSPVQISNHFETLGHQGSYLATLP- ATP7B_MOUSE ATP7B_MOUSE GFEAAIKNRTAPLRLGPIDVNKLESTN---LKKETVSPVQISNHFETLGHQGSYLATLP- B1AQ56_MOUSE B1AQ56_MOUSE GFEAAIKNRTAPLRLGPIDVNKLESTN---LKKETVSPVQISNHFETLGHQGSYLATLP- ATP7B_RAT ATP7B_RAT GFEAAIKNRTAPLRLGPIDINKLESTN---LKRAAVPPIQNSNHLETPGHQQNHLATLP- Q9QUG4_RAT Q9QUG4_RAT GFEAAIKNRTAPLRLGPIDINKLESTN---LKRAAVPPIQNSNHLETPGHQQNHLATLP- Q9R0T2_RAT Q9R0T2_RAT GFEAAIKNRTAPLRLGPIDINKLESTN---LKRAAVPPIQNSNHLETPGHQQNHLATLP- B0EVF7_CANFA B0EVF7_CANFA GFEAVIKNRVAPVSLGPIDIGRLQRTN---PKMPLTSDNQNLNNSETLGHQGSHVVTLQ- Q4U3G5_CANFA Q4U3G5_CANFA GFEAVIKNRVAPVSLGPIDIGRLQRTN---PKMPLTSDNQNLNNSETLGHQGSHVVTLQ- B7ZLR2_HUMAN B7ZLR2_HUMAN GFEAAIKSKVAPLSLGPIDIERLQSTN---PKRPLSSANQNFNNSETLGHQGSHVVTLQ- B7ZLR3_HUMAN B7ZLR3_HUMAN GFEAAIKSKVAPLSLGPIDIERLQSTN---PKRPLSSANQNFNNSETLGHQGSHVVTLQ- B7ZLR4_HUMAN B7ZLR4_HUMAN GFEAAIKSKVAPLSLGPIDIERLQSTN---PKRPLSSANQNFNNSETLGHQGSHVVTLQ- ATP7B_HUMAN ATP7B_HUMAN GFEAAIKSKVAPLSLGPIDIERLQSTN---PKRPLSSANQNFNNSETLGHQGSHVVTLQ- Q17RT3_HUMAN Q17RT3_HUMAN GFEAAIKSKVAPLSLGPIDIERLQSTN---PKRPLSSANQNFNNSETLGHQGSHVVTLQ- ATP7B_SHEEP ATP7B_SHEEP GFEAVIKNKVAPVSLGPIDVRRLQSTL---SVAPPAPVNQNDNNSETPGGQG---VPLH- A5A789_PIG A5A789_PIG GFDAVIKNKVAPVSLGPIDVGRLQSTH---PKAPPAPADQNGSSAESSGRQG---VTLH- A5A788_PIG A5A788_PIG GFPVFIKKQPKYLKLGAIDIERLKNTP---VKSLEGSPQRSTSYTNN--------STVI- ATP7A_HUMAN ATP7A_HUMAN GFPAFVKKQPKYLKLGAIDVERLKNTP---VKSSEGSQQRSPSYTND--------STAT- ATP7A_CRIGR ATP7A_CRIGR GFPAFVKKQPKYLKLGAIDVERLKNTP---VKSLEGSQQR-PSYPSD--------STAT- ATP7A_RAT ATP7A_RAT GFPAFIKKQPKYLKLGAIDVERLKSTP---VKSSEGSQQKSPAYPSD--------SAIT- ATP7A_MOUSE ATP7A_MOUSE GFPAFIKKQPKYLKLGAIDVERLKNTP---VKSSEGSQQKSPSYPSD--------STTM- B9EJ97_MOUSE B9EJ97_MOUSE GFPAFIKKQPKYLKLGAIDVERLKNTP---VKSSEGSQQKSPSYPSD--------STTM- A2AG68_MOUSE A2AG68_MOUSE GFPAFIKKQPKYLKLGAIDVERLKNTP---VKSSEGSQQKSPSYPSD--------STTM- A2AG69_MOUSE A2AG69_MOUSE GFPAFIKKQPKYLKLGAIDVERLKNTP---VKSSEGSQQKSPSYPSD--------STTM- Q4F8H5_DANRE Q4F8H5_DANRE GFKATVKSKPRQLKLSASEVERLLSAP----KQTEEKLSEPPADST---------VTTL- Q4SJX4_TETNG Q4SJX4_TETNG GFKAFVKTKPRPLQLSSDEFQRFVDSEKQAISSPSDTSEETEIFIDT--------VPAM- MATCH ** : * . : . CONSENSUS GF?A?IK?????L?LG?ID???L??T?????K????????????????????????T???

Q4SDE7_TETNG Q4SDE7_TETNG LVRVDYDASVLTERDLVLAVQNRGLDVESVFWLRVEGAHSQPSIQTIQEQLGSLAGVSDV B1AQ57_MOUSE B1AQ57_MOUSE --------------------------------LRIDGMHY-------------------- ATP7B_MOUSE ATP7B_MOUSE --------------------------------LRIDGMHCKSCVLNIEGNIGQLPGVQNI B1AQ56_MOUSE B1AQ56_MOUSE --------------------------------LRIDGMHCKSCVLNIEGNIGQLPGVQNI ATP7B_RAT ATP7B_RAT --------------------------------LRIDGMHCKSCVLNIEGNIGQLPGVQNI Q9QUG4_RAT Q9QUG4_RAT --------------------------------LRIDGMHCKSCVLNIEGNIGQLPGVQNI Q9R0T2_RAT Q9R0T2_RAT --------------------------------LRIDGMHCKSCVLNIEGNIGQLPGVQNI B0EVF7_CANFA B0EVF7_CANFA --------------------------------LRVDGMHCQSCVLNIEENIGQLPGVQNV Q4U3G5_CANFA Q4U3G5_CANFA --------------------------------LRVDGMHCQSCVLNIEENIGQLPGVQNV B7ZLR2_HUMAN B7ZLR2_HUMAN --------------------------------LRIDGMHCKSCVLNIEENIGQLLGVQSI B7ZLR3_HUMAN B7ZLR3_HUMAN --------------------------------LRIDGMHCKSCVLNIEENIGQLLGVQSI B7ZLR4_HUMAN B7ZLR4_HUMAN --------------------------------LRIDGMHCKSCVLNIEENIGQLLGVQSI ATP7B_HUMAN ATP7B_HUMAN --------------------------------LRIDGMHCKSCVLNIEENIGQLLGVQSI Q17RT3_HUMAN Q17RT3_HUMAN --------------------------------LRIDGMHCKSCVLNIEENIGQLLGVQSI ATP7B_SHEEP ATP7B_SHEEP --------------------------------LRVDGMHCKSCVLNIEDNIGQLPGVQSI A5A789_PIG A5A789_PIG --------------------------------LRVDGMHCKSCVLNIEENIGQLPGVQSI A5A788_PIG A5A788_PIG --------------------------------FIIDGMHCKSCVSNIESALSTLQYVSSI ATP7A_HUMAN ATP7A_HUMAN --------------------------------FIIDGMHCKSCVSNIESTLSALQYVSSI ATP7A_CRIGR ATP7A_CRIGR --------------------------------FIIEGMHCKSCVSNIESALPTLQYVSSI ATP7A_RAT ATP7A_RAT --------------------------------FTIDGMHCKSCVSNIESALSTLQYVSSI ATP7A_MOUSE ATP7A_MOUSE --------------------------------FTIEGMHCKSCVSNIESALSTLQYVSSI B9EJ97_MOUSE B9EJ97_MOUSE --------------------------------FTIEGMHCKSCVSNIESALSTLQYVSSI A2AG68_MOUSE A2AG68_MOUSE --------------------------------FTIEGMHCKSCVSNIESALSTLQYVSSI A2AG69_MOUSE A2AG69_MOUSE --------------------------------FTIEGMHCKSCVSNIESALSTLQYVSSI Q4F8H5_DANRE Q4F8H5_DANRE --------------------------------FQVTGMHCNSCVVNIQDNISKLPAVTSV Q4SJX4_TETNG Q4SJX4_TETNG --------------------------------LRVKGMHCRSCVVNIQDNISKLPGVSSV MATCH : : * * CONSENSUS ????????????????????????????????????GMHC?SCV?NIE?????L??V???

Q4SDE7_TETNG Q4SDE7_TETNG RGSLQECAVMVTYRPLLVTQQALKEHIRDLGFSSWSLADA--------------ALSCWQ B1AQ57_MOUSE B1AQ57_MOUSE ------------------------------------------------------------ ATP7B_MOUSE ATP7B_MOUSE HVSLENKTAQIQYDPSCVTPMFLQTAIEALPPGHFKVSLP----DGVEE-----NEPQSG B1AQ56_MOUSE B1AQ56_MOUSE HVSLENKTAQIQYDPSCVTPMFLQTAIEALPPGHFKVSLP----DGVEE-----NEPQSG ATP7B_RAT ATP7B_RAT HVSLENKTAQVQYDSSCITPLFLQTAIEALPPGYFKVSLP----DGLEKESGSSSVPSLG Q9QUG4_RAT Q9QUG4_RAT HVSLENKTAQVQYDSSCITPLFLQTAIEALPPGYFKVSLP----DGLEKESGSSSVPSLG Q9R0T2_RAT Q9R0T2_RAT HVSLENKTAQVQYDSSCITPLFLQTAIEALPPGYFKVSLP----DGLEKESGSSSVPSLG B0EVF7_CANFA B0EVF7_CANFA QVSLENRTAQVQYDPSCVTAGALQRAIEALPPGNFKVSLPAA-AAGSETGNRFSACAAPA Q4U3G5_CANFA Q4U3G5_CANFA QVSLENRTAQVQYDPSCVTAGALQRAIEALPPGNFKVSLPAA-AAGSETGNRFSACAAPA B7ZLR2_HUMAN B7ZLR2_HUMAN QVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDG-AEGSGTDHRSSSSHSPG B7ZLR3_HUMAN B7ZLR3_HUMAN QVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDG-AEGSGTDHRSSSSHSPG B7ZLR4_HUMAN B7ZLR4_HUMAN QVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDG-AEGSGTDHRSSSSHSPG ATP7B_HUMAN ATP7B_HUMAN QVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDG-AEGSGTDHRSSSSHSPG Q17RT3_HUMAN Q17RT3_HUMAN QVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDG-AEGSGTDHRSSSSHSPG ATP7B_SHEEP ATP7B_SHEEP HVSLESRTARVQYNPSLVSPGALRRAIEALPPGNFKVSFPNGA-EGSGPDSRTPPAP--- A5A789_PIG A5A789_PIG RVSLEKRTARVQYDPSCVSPGALQAAIEALPPGNFRVSLPDGAAEGTGTDARSRPHRSPG A5A788_PIG A5A788_PIG VVSLENRTAIVKYNASLVTPETLRKAIEDISPGQYRVTST----SDIECTSNSPSSSSLQ ATP7A_HUMAN ATP7A_HUMAN VVSLENRSAIVKYNASSVTPESLRKAIEAVSPGLYRVSIT----SEVESTSNSPSSSSLQ ATP7A_CRIGR ATP7A_CRIGR AVSLENRSAIVKYNASSVTPEMLIKAIEAVSPGQYRVSIA----NEVESTSSSPSSSSLQ ATP7A_RAT ATP7A_RAT VVSLENRSAIVKYNASLVTPEILRKAIEAVSPGQYRVSIS----SEVESPTSSPSSSSLQ ATP7A_MOUSE ATP7A_MOUSE VVSLENRSAIVKYNASLVTPEMLRKAIEAISPGQYRVSIA----SEVESTASSPSSSSLQ B9EJ97_MOUSE B9EJ97_MOUSE VVSLENRSAIVKYNASLVTPEMLRKAIEAISPGQYRVSIA----SEVESTASSPSSSSLQ A2AG68_MOUSE A2AG68_MOUSE VVSLENRSAIVKYNASLVTPEMLRKAIEAISPGQYRVSIA----SEVESTASSPSSSSLQ A2AG69_MOUSE A2AG69_MOUSE VVSLENRSAIVKYNASLVTPEMLRKAIEAISPGQYRVSIA----SEVESTASSPSSSSLQ Q4F8H5_DANRE Q4F8H5_DANRE VVSLENRQASIQHNPKQVSVVELQKAIEALPPGNFKAIIP--------------ASPEPG Q4SJX4_TETNG Q4SJX4_TETNG EVSLEEERASVCYDPLKVTLSQLQQAIEALPPGNFRAQPWES-PDPVRSATTSPAPDFLL MATCH CONSENSUS ?VSLEN??A?V?Y??S??????L??AIEA??PG???VS??????????????????????

Q4SDE7_TETNG Q4SDE7_TETNG EVSSDWS---------------AHSVTLCIAGMTCSSCSSSIQERISQMGGVKSIAVSLS B1AQ57_MOUSE B1AQ57_MOUSE --------------------------------------------MLSQRKGVQQTSISLA ATP7B_MOUSE ATP7B_MOUSE SSQRHQE-----------QGP-GRTAVLTISGITCASSVQPIEDMLSQRKGVQQTSISLA B1AQ56_MOUSE B1AQ56_MOUSE SSQRHQE-----------QGP-GRTAVLTISGITCASSVQPIEDMLSQRKGVQQTSISLA ATP7B_RAT ATP7B_RAT SSQRQQE-----------PGP-CRTAVLTITGIPRDSSVQPMEDMLSQMKGVQQIDISLA Q9QUG4_RAT Q9QUG4_RAT SSQRQQE-----------PGP-CRTAVLTITGIPRDSSVQPMEDMLSQMKGVQQIDISLA Q9R0T2_RAT Q9R0T2_RAT SSQRQQE-----------PGP-CRTAVLTITGIPRDSSVQPMEDMLSQMKGVQQIDISLA B0EVF7_CANFA B0EVF7_CANFA PAPRTPA-----------PGR-CDTVMLAIVGMTCASCVQSIEGLISQREGVQQISVSLA Q4U3G5_CANFA Q4U3G5_CANFA PAPRTPA-----------PGR-CDTVMLAIVGMTCASCVQSIEGLISQREGVQQISVSLA B7ZLR2_HUMAN B7ZLR2_HUMAN SPPRNQV-----------QGT-CSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLA B7ZLR3_HUMAN B7ZLR3_HUMAN SPPRNQV-----------QGT-CSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLA B7ZLR4_HUMAN B7ZLR4_HUMAN SPPRNQV-----------QGT-CSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLA ATP7B_HUMAN ATP7B_HUMAN SPPRNQV-----------QGT-CSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLA Q17RT3_HUMAN Q17RT3_HUMAN SPPRNQV-----------QGT-CSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLA ATP7B_SHEEP ATP7B_SHEEP ------------------SAP--CTMMLAIAGMTCKSCVQSIEGLISQRVGVHQISVFLA A5A789_PIG A5A789_PIG PPWSPPA-----------PGV-CCTAELAIRGMTCASCVQSIEGLVSQKEGVYHISVSLA A5A788_PIG A5A788_PIG KSPLNIV-----------SQPLTQEAVINIDGMTCNSCVQSIEGVISKKPGVKYIRISLA ATP7A_HUMAN ATP7A_HUMAN KIPLNVV-----------SQPLTQETVINIDGMTCNSCVQSIEGVISKKPGVKSIRVSLA ATP7A_CRIGR ATP7A_CRIGR KMPLNVV-----------SQPLTQETVINISGMTCNSCVQSIEGVVSKKPGVKSIHVSLA ATP7A_RAT ATP7A_RAT KMPLNLV-----------SQPLTQEVVININGMTCNSCVQSIEGVISKKPGVKSIHVSLT ATP7A_MOUSE ATP7A_MOUSE KMPLNIV-----------SQPLTQEAVININGMTCNSCVQSIEGVISKKPGVKSIHVSLA B9EJ97_MOUSE B9EJ97_MOUSE KMPLNIV-----------SQPLTQEAVININGMTCNSCVQSIEGVISKKPGVKSIHVSLA A2AG68_MOUSE A2AG68_MOUSE KMPLNIV-----------SQPLTQEAVININGMTCNSCVQSIEGVISKKPGVKSIHVSLA A2AG69_MOUSE A2AG69_MOUSE KMPLNIV-----------SQPLTQEAVININGMTCNSCVQSIEGVISKKPGVKSIHVSLA Q4F8H5_DANRE Q4F8H5_DANRE FL-----------------QPLVSVAEIHIEGMTCGSCVQSIEGTLSQKKGVRSAQVSLA Q4SJX4_TETNG Q4SJX4_TETNG PQPAGSNKARPASSEPYFTQPLLSVITIHIEGMTCTSCVQSIEGMISQKKGVMSAQVSLT MATCH :*: ** : *: CONSENSUS ?????????????????????????????I?G?TC?S?V??IE???S???GV??I??SLA

Q4SDE7_TETNG Q4SDE7_TETNG DGTATVTFDPRLTEAELLQAAIEEMGFEASVQVELSGVFFFSSECANGRLSPNRTRRTTV B1AQ57_MOUSE B1AQ57_MOUSE EGTGAVLYDPSIVSLDELRTAVEDMGFEVSVNSETFTINPVRNFKSGNSVPQTMGDIAGS ATP7B_MOUSE ATP7B_MOUSE EGTGAVLYDPSIVSLDELRTAVEDMGFEVSVNSETFTINPVRNFKSGNSVPQTMGDIAGS B1AQ56_MOUSE B1AQ56_MOUSE EGTGAVLYDPSIVSLDELRTAVEDMGFEVSVNSETFTINPVRNFKSGNSVPQTMGDIAGS ATP7B_RAT ATP7B_RAT EGTGAVLYDPSVVSSDELRTAVEDMGFEVSVNPENITTNRV---SSGNSVPQAVGDSPGS Q9QUG4_RAT Q9QUG4_RAT EGTGAVLYDPSVVSSDELRTAVEDMGFEVSVNPENITTNRV---SSGNSVPQAVGDSPGS Q9R0T2_RAT Q9R0T2_RAT EGTGAVLYDPSVVSSDELRTAVEDMGFEVSVNPENITTNRV---SSGNSVPQAVGDSPGS B0EVF7_CANFA B0EVF7_CANFA EGTAVVLYDPSIIGPEELRAAVEEMGFETSVLSENGYSNHVGNHSAGNSSAHTTAGVPVS Q4U3G5_CANFA Q4U3G5_CANFA EGTAVVLYDPSIIGPEELRAAVEEMGFETSVLSENGYSNHVGNHSAGNSSAHTTAGVPVS B7ZLR2_HUMAN B7ZLR2_HUMAN EGTATVLYNPAVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTS B7ZLR3_HUMAN B7ZLR3_HUMAN EGTATVLYNPAVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTS B7ZLR4_HUMAN B7ZLR4_HUMAN EGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTS ATP7B_HUMAN ATP7B_HUMAN EGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTS Q17RT3_HUMAN Q17RT3_HUMAN EGTATVLYNPAVISPEELRAAIEDMGFEASV----------------------------- ATP7B_SHEEP ATP7B_SHEEP EGTAVVLYDPSRTHPEELRAAVEDMGFEASILAENCSSNQVGNHSAGSAVGPEAAGAPVP A5A789_PIG A5A789_PIG EGTGTVLYDPLVTQAEELRAAVEDMGFEASVLAENCSSNHVGNHSAGNATGSTAVGTPTP A5A788_PIG A5A788_PIG NGKGTVEYDPLLTSPETLREAIEDLGFDASL--------------------SDTNEPLVV ATP7A_HUMAN ATP7A_HUMAN NSNGTVEYDPLLTSPETLRGAIEDMGFDATL--------------------SDTNEPLVV ATP7A_CRIGR ATP7A_CRIGR NSFGTVEYDPLLTAPETLREVIVDMGFDAVL-------------------P-DMSEPLVV ATP7A_RAT ATP7A_RAT NSTGTIEYDPLLTSPEPLREAIEDMGFDAVL-------------------PADMKEPLVV ATP7A_MOUSE ATP7A_MOUSE NSTGTIEFDPLLTSPETLREAIEDMGFDAAL-------------------P-DMKEPLVV B9EJ97_MOUSE B9EJ97_MOUSE NSTGTIEFDPLLTSPETLREAIEDMGFDAAL-------------------PADMKEPLVV A2AG68_MOUSE A2AG68_MOUSE NSTGTIEFDPLLTSPETLREAIEDMGFDAAL-------------------PADMKEPLVV A2AG69_MOUSE A2AG69_MOUSE NSTGTIEFDPLLTSPETLREAIEDMGFDAAL-------------------P-DMKEPLVV Q4F8H5_DANRE Q4F8H5_DANRE NHQGTFEYDPLLTSPEELRAAIEDMGFDAFL-------------PETNSLVPSVVKSPSP Q4SJX4_TETNG Q4SJX4_TETNG DHSGVFEYDPVLTTPAELREAIEDMGFDAFL-------------------PATNSLLPEP MATCH : ... ::* *: .: ::**:. : CONSENSUS ??T????YDP???????LR?A?EDMGF?????????????????????????????????

Q4SDE7_TETNG Q4SDE7_TETNG ENGVGPQVTRRP------------------EVRTQRCFIAVTGMTCASCVGNIERKLRSH B1AQ57_MOUSE B1AQ57_MOUSE VQKMAPDTRGLPTHQGPGHSSETPSSPG--ATASQKCFVQIKGMTCASCVSNIERSLQRH ATP7B_MOUSE ATP7B_MOUSE VQKMAPDTRGLPTHQGPGHSSETPSSPG--ATASQKCFVQIKGMTCASCVSNIERSLQRH B1AQ56_MOUSE B1AQ56_MOUSE VQKMAPDTRGLPTHQGPGHSSETPSSPG--ATASQKCFVQIKGMTCASCVSNIERSLQRH ATP7B_RAT ATP7B_RAT VQNMASDTRGLLTHQGPGYLSDSPPSPG--GTASQKCFVQIKGMTCASCVSNIERSLQRH Q9QUG4_RAT Q9QUG4_RAT VQNMASDTRGLLTHQGPGYLSDSPPSPG--GTASQKCFVQIKGMTCASCVSNIERSLQRH Q9R0T2_RAT Q9R0T2_RAT VQNMASDTRGLLTHQGPGYLSDSPPSPG--GTASQKCFVQIKGMTCASCVSNIERSLQRH B0EVF7_CANFA B0EVF7_CANFA VQEGAPHTEGLPGNHSPGRPSRSPPAST--SVTAQKCFLQITGMTCASCVSNIERKLQKE Q4U3G5_CANFA Q4U3G5_CANFA VQEGAPHTEGLPGNHSPGRPSRSPPAST--SVTAQKCFLQITGMTCASCVSNIERKLQKE B7ZLR2_HUMAN B7ZLR2_HUMAN LQEVAPHTGRLPANHAPDILAKSPQSTR--AVAPQKCFLQIKGMTCASCVSNIERNLQKE B7ZLR3_HUMAN B7ZLR3_HUMAN LQEVAPHTGRLPANHAPDILAKSPQSTR--AVAPQKCFLQIKGMTCASCVSNIERNLQKE B7ZLR4_HUMAN B7ZLR4_HUMAN VQEVAPHTGRLPANHAPDILAKSPQSTR--AVAPQKCFLQIKGMTCASCVSNIERNLQKE ATP7B_HUMAN ATP7B_HUMAN VQEVAPHTGRLPANHAPDILAKSPQSTR--AVAPQKCFLQIKGMTCASCVSNIERNLQKE Q17RT3_HUMAN Q17RT3_HUMAN ------------------------------------------------------------ ATP7B_SHEEP ATP7B_SHEEP MQGEAPQPGGLHTNHIPHQSPKSLLAST--TVAPKKCFLQISGMTCASCVSNIERNLQKE A5A789_PIG A5A789_PIG VQEGAPHPGGLPTNHHPGRASEIPQASA--AVAPQKCFLQITGMTCASCVSNIERNLQKE A5A788_PIG A5A788_PIG IAQSSSEMPLLTSTNEFNSKMMTPVHDKEETKTSSKCYIQVTGMTCASCVANIERNLRRE ATP7A_HUMAN ATP7A_HUMAN IAQPSSEMPLLTSTNEFYTKGMTPVQDKEEGKNSSKCYIQVTGMTCASCVANIERNLRRE ATP7A_CRIGR ATP7A_CRIGR IAQPSLETPLLPSTNDQDNMM---------TAVHSKCYIQVSGMTCASCVANIERNLRRE ATP7A_RAT ATP7A_RAT IAQPSLETPLLPSTTEPENVM---------TPVQNKCYIQVSGMTCASCVANIERNLRRE ATP7A_MOUSE ATP7A_MOUSE IAQPSLETPLLPSSNEPENVM---------TSVQNKCYIQVSGMTCASCVANIERNLRRE B9EJ97_MOUSE B9EJ97_MOUSE IAQPSLETPLLPSSNEPENVM---------TSVQNKCYIQVSGMTCASCVANIERNLRRE A2AG68_MOUSE A2AG68_MOUSE IAQPSLETPLLPSSNELENVM---------TSVQNKCYIQVSGMTCASCVANIERNLRRE A2AG69_MOUSE A2AG69_MOUSE IAQPSLETPLLPSSNELENVM---------TSVQNKCYIQVSGMTCASCVANIERNLRRE Q4F8H5_DANRE Q4F8H5_DANRE SVRSSSLSPVRSAVKENEAESDAEPS----TNTISKCFIQIGGMTCASCVANIERNLKNE Q4SJX4_TETNG Q4SJX4_TETNG ACKRSNSSSVALVRNELNSSFRKEPPRDQDGASHSKCYIHIGGMTCASCVANIERNLKNE MATCH CONSENSUS ??????????L????????????????????????KC??Q??GMTCASCV?NIER?L???

Q4SDE7_TETNG Q4SDE7_TETNG GGSHADLCPGITAVFVSLMAAKAEVTYDPDSIGAAGVARLIEDLGFGATVMDQAAANPGL B1AQ57_MOUSE B1AQ57_MOUSE --------AGILSVLVALMSGKAEVKYDPEIIQSPRIAQLIQDLGFEASVMEDNTVSEGD ATP7B_MOUSE ATP7B_MOUSE --------AGILSVLVALMSGKAEVKYDPEIIQSPRIAQLIQDLGFEASVMEDNTVSEGD B1AQ56_MOUSE B1AQ56_MOUSE --------AGILSVLVALMSGKAEVKYDPEIIQSPRIAQLIQDLGFEASVMEDNTVSEGD ATP7B_RAT ATP7B_RAT --------AGILSVLVALMSGKAEVKYDPEVIQSPRIAQLIEDLGFEAAIMEDNTVSEGD Q9QUG4_RAT Q9QUG4_RAT --------AGILSVLVALMSGKAEVKYDPEVIQSPRIAQLIEDLGFEAAIMEDNTVSEGD Q9R0T2_RAT Q9R0T2_RAT --------AGILSVLVALMSGKAEVKYDPEVIQSPRIAQLIEDLGFEAAIMEDNTVSEGD B0EVF7_CANFA B0EVF7_CANFA --------AGVVSVLVALMAGKAEVKYHPDVIQPLEIAQLIQDLGFEATVLEDYAGSEGD Q4U3G5_CANFA Q4U3G5_CANFA --------AGVVSVLVALMAGKAEVKYHPDVIQPLEIAQLIQDLGFEATVLEDYAGSEGD B7ZLR2_HUMAN B7ZLR2_HUMAN --------AGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVMEDYAGSDGN B7ZLR3_HUMAN B7ZLR3_HUMAN --------AGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVMEDYAGSDGN B7ZLR4_HUMAN B7ZLR4_HUMAN --------AGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVMEDYAGSDGN ATP7B_HUMAN ATP7B_HUMAN --------AGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVMEDYAGSDGN Q17RT3_HUMAN Q17RT3_HUMAN ------------------------------------------------------------ ATP7B_SHEEP ATP7B_SHEEP --------PGILSVLVALMAGKAEVKYNPEAIQPLEIAKLVQDLGFEAAVMEDYTGSDGD A5A789_PIG A5A789_PIG --------AGILSVLVALMAGKAEVKYNPDVIQPLEIAQLIRELGFEATVLEDYKGSDGD A5A788_PIG A5A788_PIG --------EGIYSVLVALMAGKAEVRYNPAVIQPLMIAELIRELGFGTTVMENTDEGDGV ATP7A_HUMAN ATP7A_HUMAN --------EGIYSILVALMAGKAEVRYNPAVIQPPMIAEFIRELGFGATVIENADEGDGV ATP7A_CRIGR ATP7A_CRIGR --------EGIYSVLVALMAGKAEVRYNPAVIQPPVIAEFIRELGFGATVMENADEGDGI ATP7A_RAT ATP7A_RAT --------EGIYSVLVALMAGKAEVRYNPAVIQPRVIAELIRELGFGAVVMENAGEGNGI ATP7A_MOUSE ATP7A_MOUSE --------EGIYSVLVALTAGKAEVRYNPAVIQPRVIAEFIRELGFGAMVMENAGEGNGI B9EJ97_MOUSE B9EJ97_MOUSE --------EGIYSVLVALMAGKAEVRYNPAVIQPRVIAEFIRELGFGAMVMENAGEGNGI A2AG68_MOUSE A2AG68_MOUSE --------EGIYSVLVALMAGKAEVRYNPAVIQPRVIAEFIRELGFGAMVMENAGEGNGI A2AG69_MOUSE A2AG69_MOUSE --------EGIYSVLVALMAGKAEVRYNPAVIQPRVIAEFIRELGFGAMVMENAGEGNGI Q4F8H5_DANRE Q4F8H5_DANRE --------YGIHSVLVALMASKAEVRYSPSVIDPLRIAELIRELGFTATVMDNYDGSDGS Q4SJX4_TETNG Q4SJX4_TETNG --------TGIYSVLVALMASKAEVRYNPELIDPLKMAECVKELGFTASVMENYEGSDGN MATCH CONSENSUS ?????????G??SVLVALM?GKAEV?Y?P??IQ???IA??I??LGF?A?VME??????G?

Q4SDE7_TETNG Q4SDE7_TETNG LELRLSGMTCASCVHKIESKLRSTPGVMAATVSLATNRAQVRYHPEAVGARDLLAIIQDL B1AQ57_MOUSE B1AQ57_MOUSE IELIITGMTCASCVHNIESKLTRTNGITYASVALATSKAHVKFDPEIVGPRDIIKIIEEI ATP7B_MOUSE ATP7B_MOUSE IELIITGMTCASCVHNIESKLTRTNGITYASVALATSKAHVKFDPEIVGPRDIIKIIEEI B1AQ56_MOUSE B1AQ56_MOUSE IELIITGMTCASCVHNIESKLTRTNGITYASVALATSKAHVKFDPEIVGPRDIIKIIEEI ATP7B_RAT ATP7B_RAT IELIITGMTCASCVHNIESKLTRTNGITYASVALATSKAHVKFDPEIIGPRDIIKVIEEI Q9QUG4_RAT Q9QUG4_RAT IELIITGMTCASCVHNIESKLTRTNGITYASVALATSKAHVKFDPEIIGPRDIIKVIEEI Q9R0T2_RAT Q9R0T2_RAT IELIITGMTCASCVHNIESKLTRTNGITYASVALATSKAHVKFDPEIIGPRDIIKVIEEI B0EVF7_CANFA B0EVF7_CANFA LELIITGMTCASCVHNIESKLTRMAGITYASVALATSKAHVKFDPEIIGPRDIVKVIEEI Q4U3G5_CANFA Q4U3G5_CANFA LELIITGMTCASCVHNIESKLTRMAGITYASVALATSKAHVKFDPEIIGPRDIVKVIEEI B7ZLR2_HUMAN B7ZLR2_HUMAN IELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEI B7ZLR3_HUMAN B7ZLR3_HUMAN IELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEI B7ZLR4_HUMAN B7ZLR4_HUMAN IELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEI ATP7B_HUMAN ATP7B_HUMAN IELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEI Q17RT3_HUMAN Q17RT3_HUMAN ------------------------------------------------------------ ATP7B_SHEEP ATP7B_SHEEP LELMITGMTCASCVHNIESKLRRTEGITYASVALATSKAHVKFDPEIIGPRDIVKLIEEI A5A789_PIG A5A789_PIG LELVVTGMTCTSCVHNIESRLTRTNGVTYASVALATSKAHVKFDPELIGPRDIVRIIEEI A5A788_PIG A5A788_PIG LELVVRGMTCASCVHKIESTLTKHRGIFYCSVALATNKAHIKYDPEIIGPRDIIHVIESL ATP7A_HUMAN ATP7A_HUMAN LELVVRGMTCASCVHKIESSLTKHRGILYCSVALATNKAHIKYDPEIIGPRDIIHTIESL ATP7A_CRIGR ATP7A_CRIGR LKLVVRGMTCASCVHKIESTLTKHKGIFYCSVALATNKAHIKYDPEIIGPRDIIHTIGSL ATP7A_RAT ATP7A_RAT LELVVRGMTCASCVHKIESTLTKHKGIFYCSVALATNKAHIKYDPEIIGPRDIIHTIGNL ATP7A_MOUSE ATP7A_MOUSE LELVVRGMTCASCVHKIESTLTKHKGIFYCSVALATNKAHIKYDPEIIGPRDIIHTIGSL B9EJ97_MOUSE B9EJ97_MOUSE LELVVRGMTCASCVHKIESTLTKHKGIFYCSVALATNKAHIKYDPEIIGPRDIIHTIGSL A2AG68_MOUSE A2AG68_MOUSE LELVVRGMTCASCVHKIESTLTKHKGIFYCSVALATNKAHIKYDPEIIGPRDIIHTIGSL A2AG69_MOUSE A2AG69_MOUSE LELVVRGMTCASCVHKIESTLTKHKGIFYCSVALATNKAHIKYDPEIIGPRDIIHTIGSL Q4F8H5_DANRE Q4F8H5_DANRE LELVVRGMTCASCVHKIESNLMKQKGILYASVALSTNKAHIKYDPEVTGPRDIIRLIENM Q4SJX4_TETNG Q4SJX4_TETNG LELVVKGMTCASCVHKIESNLTKRKGIIYVSVALATNKAHVKYDVEIIGPRDIIKLIENL MATCH CONSENSUS ?EL???GMTCASCVH?IES?LT???GI?Y?SVALAT?KA??K?DPEI?GPRDI???I???

Q4SDE7_TETNG Q4SDE7_TETNG GFQAEL-EKTGLKQNLDHSKEILQWRNSFLLSLVFGLPVMGLMVYMMVMDS--------- B1AQ57_MOUSE B1AQ57_MOUSE GFHASLAQRNPNAHHLDHKTEIKQWKKSFLCSLVFGIPVMGLMVYMLIPSS--------- ATP7B_MOUSE ATP7B_MOUSE GFHASLAQRNPNAHHLDHKTEIKQWKKSFLCSLVFGIPVMGLMVYMLIPSS--------- B1AQ56_MOUSE B1AQ56_MOUSE GFHASLAQRNPNAHHLDHKTEIKQWKKSFLCSLVFGIPVMGLMVYMLIPSS--------- ATP7B_RAT ATP7B_RAT GFHASLAHRNPNAHHLDHKTEIKQWKKSFLCSLVFGIPVMGLMIYMLIPSS--------- Q9QUG4_RAT Q9QUG4_RAT GFHASLAHRNPNAHHLDHKTEIKQWKKSFLCSLVFGIPVMGLMIYMLIPSS--------- Q9R0T2_RAT Q9R0T2_RAT GFHASLAHRNPNAHHLDHKTEIKQWKKSFLCSLVFGIPVMGLMIYMLIPSS--------- B0EVF7_CANFA B0EVF7_CANFA GFHASPAQRNPSAHHLDHKVEIKQWKKSFLCSLVFGIPVMGLMIYMLVPSS--------- Q4U3G5_CANFA Q4U3G5_CANFA GFHASPAQRNPSAHHLDHKVEIKQWKKSFLCSLVFGIPVMGLMIYMLVPSS--------- B7ZLR2_HUMAN B7ZLR2_HUMAN GFHASLAQRNPNAHHLDHKMEIKQWKKSFLCSLVFGIPVMALMIYMLIPSN--------- B7ZLR3_HUMAN B7ZLR3_HUMAN GFHASLAQRNPNAHHLDHKMEIKQWKKSFLCSLVFGIPVMALMIYMLIPSN--------- B7ZLR4_HUMAN B7ZLR4_HUMAN GFHASLAQRNPNAHHLDHKMEIKQWKKSFLCSLVFGIPVMALMIYMLIPSN--------- ATP7B_HUMAN ATP7B_HUMAN GFHASLAQRNPNAHHLDHKMEIKQWKKSFLCSLVFGIPVMALMIYMLIPSN--------- Q17RT3_HUMAN Q17RT3_HUMAN ------------------------------------------------------------ ATP7B_SHEEP ATP7B_SHEEP GFRASLAQRIPNAHHLDHKVEIKQWKNSFLCSLVFGIPVMGLMIYMLIPSH--------- A5A789_PIG A5A789_PIG GFHASLAQRNPKAHHLDHKVEIKQWKKSFLCSLVFGIPVMGLMIYMLIPSH--------- A5A788_PIG A5A788_PIG GFEASLVKKDRSASHLDHKREIRQWRRAFLVSLFFCIPVMGLMIYMMVMDHHLATLHHNQ ATP7A_HUMAN ATP7A_HUMAN GFEASLVKKDRSASHLDHKREIRQWRRSFLVSLFFCIPVMGLMIYMMVMDHHFATLHHNQ ATP7A_CRIGR ATP7A_CRIGR GFEASLVKKDRSASHLDHKREIKQWRSSFLVSLFFCTPVMGLMMYMMAMEHHFATIHHNQ ATP7A_RAT ATP7A_RAT GFEASLVKKDRSANHLDHKREIKQWRGSFLVSLFFCIPVMGLMIYMMVMDHHLATLNHNQ ATP7A_MOUSE ATP7A_MOUSE GFEASLVKKDRSANHLDHKREIKQWRGSFLVSLFFCIPVMGLMVYMMVMDHHLATLHHNQ B9EJ97_MOUSE B9EJ97_MOUSE GFEASLVKKDRSANHLDHKREIKQWRGSFLVSLFFCIPVMGLMVYMMVMDHHLATLHHNQ A2AG68_MOUSE A2AG68_MOUSE GFEASLVKKDRSANHLDHKREIKQWRGSFLVSLFFCIPVMGLMVYMMVMDHHLATLHHNQ A2AG69_MOUSE A2AG69_MOUSE GFEASLVKKDRSANHLDHKREIKQWRGSFLVSLFFCIPVMGLMVYMMVMDHHLATLHHNQ Q4F8H5_DANRE Q4F8H5_DANRE GFTASLVKKDRPGSHLDHSREIRQWKRSFQISLFFCVPVMGMMIYMIVVDHMIDKYHQHH Q4SJX4_TETNG Q4SJX4_TETNG GFEVTLVKNDRTANHLDHSKEIQQWRWSFLVSLFFCVPVMGMMMYMIVMDYKM-SVSHPH MATCH CONSENSUS GF?ASL??????A?HLDHK?EI?QW??SFL?SL?F?IPVMGLM?YM??????????????

Q4SDE7_TETNG Q4SDE7_TETNG -----QMQNHGGAMPEDQNLVPGLSLLNLAFFLLCTPVQIFGGRYFYIQAYRALQHRTAN B1AQ57_MOUSE B1AQ57_MOUSE --------TPQETMVLDHNIIPGLSVLNLIFFILCTFVQFLGGWYFYVQAYKSLRHRSAN ATP7B_MOUSE ATP7B_MOUSE --------TPQETMVLDHNIIPGLSVLNLIFFILCTFVQFLGGWYFYVQAYKSLRHRSAN B1AQ56_MOUSE B1AQ56_MOUSE --------TPQETMVLDHNIIPGLSVLNLIFFILCTFVQFLGGWYFYVQAYKSLRHRSAN ATP7B_RAT ATP7B_RAT --------KPHETMVLDHNIIPGLSVLNLIFFILCTFVQFLGGWYFYVQAYKSLRHKSAN Q9QUG4_RAT Q9QUG4_RAT --------KPHETMVLDHNIIPGLSVLNLIFFILCTFVQFLGGWYFYVQAYKSLRHKSAN Q9R0T2_RAT Q9R0T2_RAT --------KPHETMVLDHNIIPGLSVLNLIFFILCTFVQFLGGWYFYVQAYKSLRHKSAN B0EVF7_CANFA B0EVF7_CANFA --------TPHESMVLDHNVIPGLSILNLIFFILCTFVQLLGGWYFYVQAYRSLRHRAAN Q4U3G5_CANFA Q4U3G5_CANFA --------TPHESMVLDHNVIPGLSILNLIFFILCTFVQLLGGWYFYVQAYRSLRHRAAN B7ZLR2_HUMAN B7ZLR2_HUMAN --------EPHQSMVLDHNIIPGLSILNLIFFILCTFVQLLGGWYFYVQAYKSLRHRSAN B7ZLR3_HUMAN B7ZLR3_HUMAN --------EPHQSMVLDHNIIPGLSILNLIFFILCTFVQ--------------------- B7ZLR4_HUMAN B7ZLR4_HUMAN --------EPHQSMVLDHNIIPGLSILNLIFFILCTFVQ--------------------- ATP7B_HUMAN ATP7B_HUMAN --------EPHQSMVLDHNIIPGLSILNLIFFILCTFVQLLGGWYFYVQAYKSLRHRSAN Q17RT3_HUMAN Q17RT3_HUMAN ------------------------------------------------------------ ATP7B_SHEEP ATP7B_SHEEP --------EPQSS-VLDHNVIPGLSILNLIFFILCTFVQFLGGWYFYVQAYKSLRHGMAN A5A789_PIG A5A789_PIG --------GPHEAMVLDHNIIPGLSILNLIFFILCTFVQFLGGWYFYVQAYKSLRHGAAN A5A788_PIG A5A788_PIG NMSQEEMINSHSSMFLERQILPGLSIMNLLSFLLCIPVQFFGGWHFYIQAYKALKHKTAN ATP7A_HUMAN ATP7A_HUMAN NMSKEEMINLHSSMFLERQILPGLSVMNLLSFLLCVPVQFFGGWYFYIQAYKALKHKTAN ATP7A_CRIGR ATP7A_CRIGR SMSNEEMIKNHSSMFLERQILPGLSIMNLLSLLLCLPVQFFGGWYFYIQAYKALKHKTAN ATP7A_RAT ATP7A_RAT NMSNEEMINMHSSMFLERQILPGLSIMNLLSLLLCLPVQFCGGWYFYIQAYKALRHKTAN ATP7A_MOUSE ATP7A_MOUSE NMSNEEMINMHSAMFLERQILPGLSIMNLLSLLLCLPVQFCGGWYFYIQAYKALKHKTAN B9EJ97_MOUSE B9EJ97_MOUSE NMSNEEMINMHSAMFLERQILPGLSIMNLLSLLLCLPVQFCGGWYFYIQAYKALKHKTAN A2AG68_MOUSE A2AG68_MOUSE NMSNEEMINMHSAMFLERQILPGLSIMNLLSLLLCLPVQFCGGWYFYIQAYKALKHKTAN A2AG69_MOUSE A2AG69_MOUSE NMSNEEMINMHSAMFLERQILPGLSIMNLLSLLLCLPVQFCGGWYFYIQAYKALKHKTAN Q4F8H5_DANRE Q4F8H5_DANRE NATAEDRAKYHSTMFLEKQLLPGLSIMNLISFLFCVPVQFIGGRYFYCQAYKAVKHRTAN Q4SJX4_TETNG Q4SJX4_TETNG NLTAEERNHYHSSMVLEWQVAPGLSIMNLLSFIFCIPVQFIGGRKFYIQAYKSVKHRSAN MATCH CONSENSUS ?????????????M?L?????PGLS??NL????LC??VQ??GG?YFY?QAY??L?H??AN

Q4SDE7_TETNG Q4SDE7_TETNG MDVLIVLATSIAYVYSCVVLVVAMAEQAQQSPTTFFDTPPMLFVFIALGRWLEHIAKSKT B1AQ57_MOUSE B1AQ57_MOUSE MDVLIVLATTIAYAYSLVILVVAVAEKAEKSPVTFFDTPPMLFVFIALGRWLEHVAKSKT ATP7B_MOUSE ATP7B_MOUSE MDVLIVLATTIAYAYSLVILVVAVAEKAEKSPVTFFDTPPMLFVFIALGRWLEHVAKSKT B1AQ56_MOUSE B1AQ56_MOUSE MDVLIVLATTIAYAYSLVILVVAVAEKAEKSPVTFFDTPPMLFVFIALGRWLEHVAKSKT ATP7B_RAT ATP7B_RAT MDVLIVLATTIAYAYSLVILVVAIAEKAEKSPVTFFDTPPMLFVFIALGRWLEHVAKSKT Q9QUG4_RAT Q9QUG4_RAT MDVLIVLATTIAYAYSLVILVVAIAEKAEKSPVTFFDTPPMLFVFIALGRWLEHVAKSKT Q9R0T2_RAT Q9R0T2_RAT MDVLIVLATTIAYAYSLVILVVAIAEKAEKSPVTFFDTPPMLFVFIALGRWLEHVAKSKT B0EVF7_CANFA B0EVF7_CANFA MDVLIVLATSIAYTYSLVILVVAVAERAERSPVTFFDTPPMLFVFIALGRWLEHIAKSKT Q4U3G5_CANFA Q4U3G5_CANFA MDVLIVLATSIAYTYSLVILVVAVAERAERSPVTFFDTPPMLFVFIALGRWLEHIAKSKT B7ZLR2_HUMAN B7ZLR2_HUMAN MDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWLEHLAKSKT B7ZLR3_HUMAN B7ZLR3_HUMAN ---------------------------------------------------------SKT B7ZLR4_HUMAN B7ZLR4_HUMAN ---------------------------AERSPVTFFDTPPMLFVFIALGRWLEHLAKSKT ATP7B_HUMAN ATP7B_HUMAN MDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWLEHLAKSKT Q17RT3_HUMAN Q17RT3_HUMAN ------------------------------------------------------------ ATP7B_SHEEP ATP7B_SHEEP MDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWLEHVVKSKT A5A789_PIG A5A789_PIG MDVLIVLATSVAYAYSLVILVVAIAERAERSPVTFFDTPPMLFVFIALGRWLEHVAKSKT A5A788_PIG A5A788_PIG MDVLIVLATTIAFAYSLVILLVAMYERAKVNPVTFFDTPPMLFVFIALGRWLEHIAKGKT ATP7A_HUMAN ATP7A_HUMAN MDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKT ATP7A_CRIGR ATP7A_CRIGR MDVLIVLATTIAFAYSLIILLVAMYERAKVNPITSFDTPPMLFVFIALGRWLEHIAKGKT ATP7A_RAT ATP7A_RAT MDVLIVLATTIAFAYSLVILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKT ATP7A_MOUSE ATP7A_MOUSE MDVLIVLATTIAFAYSLVILLVAMFERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKT B9EJ97_MOUSE B9EJ97_MOUSE MDVLIVLATTIAFAYSLVILLVAMFERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKT A2AG68_MOUSE A2AG68_MOUSE MDVLIVLATTIAFAYSLVILLVAMFERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKT A2AG69_MOUSE A2AG69_MOUSE MDVLIVLATTIAFAYSLVILLVAMFERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKT Q4F8H5_DANRE Q4F8H5_DANRE MDVLIVLATTIAFTYSVVVLLVAMVERAKVNPITFFDTPPMLFVFISLGRWLEQIAKSKT Q4SJX4_TETNG Q4SJX4_TETNG MDVLIVLATSIAFTYSVVVLIVAMAEKAKVNPITFFDTPPMLFVFISLGRWLEQIAKSKT MATCH CONSENSUS MDVLIVLAT?IA??YS?V?L?VA??E?A???P?TFFDTPPMLFVFIALGRWLEH?AK?KT

Q4SDE7_TETNG Q4SDE7_TETNG SEALAKLISLQASDATVVTLGPDGAVLSEEQVELDLVQRGDVIKVLPGGKFPIDGRVTEG B1AQ57_MOUSE B1AQ57_MOUSE SEALAKLMSLQATEATVVTLGEDNLILREEQVPMELVQRGDVIKVVPGGKFPVDGKVLEG ATP7B_MOUSE ATP7B_MOUSE SEALAKLMSLQATEATVVTLGEDNLILREEQVPMELVQRGDVIKVVPGGKFPVDGKVLEG B1AQ56_MOUSE B1AQ56_MOUSE SEALAKLMSLQATEATVVTLGEDNLILREEQVPMELVQRGDVIKVVPGGKFPVDGKVLEG ATP7B_RAT ATP7B_RAT SEALAKLMSLQATEATVVTLGEDNLILREEQVPMELVQRGDIIKVVPGGKFPVDGKVLEG Q9QUG4_RAT Q9QUG4_RAT SEALAKLMSLQATEATVVTLGEDNLILREEQVPMELVQRGDIIKVVPGGKFPVDGKVLEG Q9R0T2_RAT Q9R0T2_RAT SEALAKLMSLQATEATVVTLGEDNLILREEQVPMELVQRGDIIKVVPGGKFPVDGKVLEG B0EVF7_CANFA B0EVF7_CANFA SEALAKLMSLQATEATVVTLGEDNLILREEQVPMELVQRGDVIKVVPGGKFPVDGKVLEG Q4U3G5_CANFA Q4U3G5_CANFA SEALAKLMSLQATEATVVTLGEDNLILREEQVPMELVQRGDVIKVVPGGKFPVDGKVLEG B7ZLR2_HUMAN B7ZLR2_HUMAN SEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVRVVPGGKFPVDGKVLEG B7ZLR3_HUMAN B7ZLR3_HUMAN SEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVRVVPGGKFPVDGKVLEG B7ZLR4_HUMAN B7ZLR4_HUMAN SEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFPVDGKVLEG ATP7B_HUMAN ATP7B_HUMAN SEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFPVDGKVLEG Q17RT3_HUMAN Q17RT3_HUMAN ------------------------------------------------------------ ATP7B_SHEEP ATP7B_SHEEP SEALARLMSLQATEATVVTLGEDNVIIREEQVPMELVQRGDIIKVVPGGKFPVDGKVLEG A5A789_PIG A5A789_PIG SEALAKLMSLQATEATVVTFGKDNLIVREEQVPMELVQRGDVIKVVPGGKFPVDGKVLEG A5A788_PIG A5A788_PIG SEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEG ATP7A_HUMAN ATP7A_HUMAN SEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEG ATP7A_CRIGR ATP7A_CRIGR SEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEG ATP7A_RAT ATP7A_RAT SEALAKLISLQATEATIVTLNSENLLLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEG ATP7A_MOUSE ATP7A_MOUSE SEALAKLISLQATEATIVTLNSENLLLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEG B9EJ97_MOUSE B9EJ97_MOUSE SEALAKLISLQATEATIVTLNSENLLLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEG A2AG68_MOUSE A2AG68_MOUSE SEALAKLISLQATEATIVTLNSENLLLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEG A2AG69_MOUSE A2AG69_MOUSE SEALAKLISLQATEATIVTLNSENLLLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEG Q4F8H5_DANRE Q4F8H5_DANRE SEALSKLMSLQATEATVVTLNEDMSVLSEEQVDVELVQRGDVVKVVPGGKFPVDGRVIEG Q4SJX4_TETNG Q4SJX4_TETNG SEALSKLMSLQATEATVVTLGSDNSILSEEQLDVDLVQRGDVVKVVPGGKFPVDGRVIEG MATCH CONSENSUS SEALAKL?SLQATEAT?VTL???N????EEQV??ELVQRGD??KVVPGGKFPVDG?V?EG

Q4SDE7_TETNG Q4SDE7_TETNG SSTADESLITGEPMPVSKKVGSLVLAGSINGHGALLVEATHVGGDTTLSQIVRLVEEAQL B1AQ57_MOUSE B1AQ57_MOUSE NTMADESLITGEAMPVTKKPGSIVIAGSINAHGSVLLKATHVGNDTTLAQIVKLVEEAQM ATP7B_MOUSE ATP7B_MOUSE NTMADESLITGEAMPVTKKPGSIVIAGSINAHGSVLLKATHVGNDTTLAQIVKLVEEAQM B1AQ56_MOUSE B1AQ56_MOUSE NTMADESLITGEAMPVTKKPGSIVIAGSINAHGSVLLKATHVGNDTTLAQIVKLVEEAQM ATP7B_RAT ATP7B_RAT NTMADESLITGEAMPVTKKPGSIVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQM Q9QUG4_RAT Q9QUG4_RAT NTMADESLITGEAMPVTKKPGSIVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQM Q9R0T2_RAT Q9R0T2_RAT NTMADESLITGEAMPVTKKPGSIVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQM B0EVF7_CANFA B0EVF7_CANFA NTMADESLITGEAMPVTKKPGSTVIAGSMNAHGSVLVTATHVGNDTTLAQIVKLVEEAQM Q4U3G5_CANFA Q4U3G5_CANFA NTMADESLITGEAMPVTKKPGSTVIAGSMNAHGSVLVTATHVGNDTTLAQIVKLVEEAQM B7ZLR2_HUMAN B7ZLR2_HUMAN NTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQM B7ZLR3_HUMAN B7ZLR3_HUMAN NTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQM B7ZLR4_HUMAN B7ZLR4_HUMAN NTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQM ATP7B_HUMAN ATP7B_HUMAN NTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQM Q17RT3_HUMAN Q17RT3_HUMAN --------VSGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQM ATP7B_SHEEP ATP7B_SHEEP NTMADESLITGEAMPVTKKPGSMVIAGSMNAHGSVLITATHVGNDTTLAQIVKLVEEAQM A5A789_PIG A5A789_PIG STMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLVTATHVGNETTLAQIVKLVEEAQM A5A788_PIG A5A788_PIG HSMVDESLITGEAMPVAKKSGSTVIAGSINQNGSLLIRATHVGADTTLSQIVKLVEEAQT ATP7A_HUMAN ATP7A_HUMAN HSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQT ATP7A_CRIGR ATP7A_CRIGR HSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQT ATP7A_RAT ATP7A_RAT HSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLIRATHVGADTTLSQIVKLVEEAQT ATP7A_MOUSE ATP7A_MOUSE HSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLIRATHVGADTTLSQIVKLVEEAQT B9EJ97_MOUSE B9EJ97_MOUSE HSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLIRATHVGADTTLSQIVKLVEEAQT A2AG68_MOUSE A2AG68_MOUSE HSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLIRATHVGADTTLSQIVKLVEEAQT A2AG69_MOUSE A2AG69_MOUSE HSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLIRATHVGADTTLSQIVKLVEEAQT Q4F8H5_DANRE Q4F8H5_DANRE HSMADESLITGEAMPVTKKPGSTVIAGSINQNGSLLIKATHVGTDTTLSQIVKLVEEAQT Q4SJX4_TETNG Q4SJX4_TETNG HSMADESLITGEAMPVTKKPGSSVIAGSINQNGSLLISATHVGLDTTLSQIVKLVEEAQT MATCH ::**.***:** ** *:***:* :*::*: ***** :***:***:****** CONSENSUS ??M?DESLITGEAMPV?KKPGS?VIAGSIN??GS?L??ATHVG?DTTL?QIVKLVEEAQ?

Q4SDE7_TETNG Q4SDE7_TETNG SKAPIQKLADRLGGLFVPFILVVSLLTLAAWLLVGFSHFHLVEQHFPVEVRHRQPNGEKL B1AQ57_MOUSE B1AQ57_MOUSE SKAPIQQLADRFSGYFVPFIIIISTLTLVVWIVIGFVDFGVVQKYFPSPSKH-------I ATP7B_MOUSE ATP7B_MOUSE SKAPIQQLADRFSGYFVPFIIIISTLTLVVWIVIGFVDFGVVQKYFPSPSKH-------I B1AQ56_MOUSE B1AQ56_MOUSE SKAPIQQLADRFSGYFVPFIIIISTLTLVVWIVIGFVDFGVVQKYFPSPSKH-------I ATP7B_RAT ATP7B_RAT SKAPIQQLADRFSGYFVPFIIIISTLTLVVWIIIGFVDFGIVQKYFPSPSKH-------I Q9QUG4_RAT Q9QUG4_RAT SKAPIQQLADRFSGYFVPFIIIISTLTLVVWIIIGFVDFGIVQKYFPSPSKH-------I Q9R0T2_RAT Q9R0T2_RAT SKAPIQQLADRFSGYFVPFIIIISTLTLVVWIIIGFVDFGIVQKYFPSPSKH-------I B0EVF7_CANFA B0EVF7_CANFA SKAPIQQLADRFSGYFVPFIIIISTLTLVVWIIIGFIDFGVVQKYFPTPNKH-------I Q4U3G5_CANFA Q4U3G5_CANFA SKAPIQQLADRFSGYFVPFIIIISTLTLVVWIIIGFIDFGVVQKYFPTPNKH-------I B7ZLR2_HUMAN B7ZLR2_HUMAN SKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQKYFP------------- B7ZLR3_HUMAN B7ZLR3_HUMAN SKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQKYFPNPNKH-------I B7ZLR4_HUMAN B7ZLR4_HUMAN SKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKH-------I ATP7B_HUMAN ATP7B_HUMAN SKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKH-------I Q17RT3_HUMAN Q17RT3_HUMAN SKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKH-------I ATP7B_SHEEP ATP7B_SHEEP SKAPIQQLADRFSGYFVPFIIIISTVTLVVWIVIGFIDFGVVQKYFPAPSKG-------I A5A789_PIG A5A789_PIG SKAPIQQLADRFSGYFVPFIIIISTLTLVVWIVIGFVDFGVVQKYFPNHSKR-------I A5A788_PIG A5A788_PIG SKAPIQQFADKLSGYFVPFIVIISIATLLVWIIIGFANFEIMETYFPGYNRS-------I ATP7A_HUMAN ATP7A_HUMAN SKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLNFEIVETYFPGYNRS-------I ATP7A_CRIGR ATP7A_CRIGR SKAPIQQFADKLGGYFVPFIVLVSIATLLVWIIIGFQNFTIVETYFPGYSRS-------I ATP7A_RAT ATP7A_RAT SKAPIQQFADKLSGYFVPFIVLVSIVTLLVWIIIGFQNFEIVEAYFPGYNRS-------I ATP7A_MOUSE ATP7A_MOUSE SKAPIQQFADKLSGYFVPFIVLVSIVTLLVWIIIGFQNFEIVETYFPGYNRS-------I B9EJ97_MOUSE B9EJ97_MOUSE SKAPIQQFADKLSGYFVPFIVLVSIVTLLVWIIIGFQNFEIVETYFPGYNRS-------I A2AG68_MOUSE A2AG68_MOUSE SKAPIQQFADKLSGYFVPFIVLVSIVTLLVWIIIGFQNFEIVETYFPGYNRS-------I A2AG69_MOUSE A2AG69_MOUSE SKAPIQQFADKLSGYFVPFIVLVSIVTLLVWIIIGFQNFEIVETYFPGYNRS-------I Q4F8H5_DANRE Q4F8H5_DANRE SKAPIQQFADKISSYFVPFIVVISVLTLLAWIIIGFVNFSLVQTYFPGYDKS-------I Q4SJX4_TETNG Q4SJX4_TETNG SKAPIQQYADKISGYFVPFIVVVSVLTLIVWIFVGFLNFALVEEYFPGYDKS-------I MATCH ******: **::.. *****:.:* ** .*:.:** .* ::: :** CONSENSUS SKAPIQQ?AD??SGYFVPFI???S??TL?VWI?IGF??F??V??YFP????????????I

Q4SDE7_TETNG Q4SDE7_TETNG GDVEMSLDPRVTTRASPEPRWSFRLTFQASITVLSIACPCSLGLATPTAVMVGTGVGARN B1AQ57_MOUSE B1AQ57_MOUSE SQTEVII----------------RFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQN ATP7B_MOUSE ATP7B_MOUSE SQTEVII----------------RFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQN B1AQ56_MOUSE B1AQ56_MOUSE SQTEVII----------------RFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQN ATP7B_RAT ATP7B_RAT SQTEVII----------------RFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQN Q9QUG4_RAT Q9QUG4_RAT SQTEVII----------------RFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQN Q9R0T2_RAT Q9R0T2_RAT SQTEVII----------------RFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQN B0EVF7_CANFA B0EVF7_CANFA SEAEVII----------------RFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQN Q4U3G5_CANFA Q4U3G5_CANFA SEAEVII----------------RFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQN B7ZLR2_HUMAN B7ZLR2_HUMAN ------------------------------------------------------------ B7ZLR3_HUMAN B7ZLR3_HUMAN SQTEVII----------------RFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQN B7ZLR4_HUMAN B7ZLR4_HUMAN SQTEVII----------------RFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQN ATP7B_HUMAN ATP7B_HUMAN SQTEVII----------------RFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQN Q17RT3_HUMAN Q17RT3_HUMAN SQTEVII----------------RFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQN ATP7B_SHEEP ATP7B_SHEEP SQAEVVL----------------RFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQN A5A789_PIG A5A789_PIG SQAEVVL----------------RFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQN A5A788_PIG A5A788_PIG SQTETII----------------RFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQN ATP7A_HUMAN ATP7A_HUMAN SRTETII----------------RFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQN ATP7A_CRIGR ATP7A_CRIGR SRTETII----------------RFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQN ATP7A_RAT ATP7A_RAT SRTETII----------------RFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQN ATP7A_MOUSE ATP7A_MOUSE SRTETII----------------RFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQN B9EJ97_MOUSE B9EJ97_MOUSE SRTETII----------------RFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQN A2AG68_MOUSE A2AG68_MOUSE SRTETII----------------RFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQN A2AG69_MOUSE A2AG69_MOUSE SRTETII----------------RFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQN Q4F8H5_DANRE Q4F8H5_DANRE SEAEAVI----------------RFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQN Q4SJX4_TETNG Q4SJX4_TETNG SRAEAVI----------------RFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQN MATCH CONSENSUS S??E??I????????????????RFAFQ?SITVLCIACPCSLGLATPTAVMVGTGV?AQN

Q4SDE7_TETNG Q4SDE7_TETNG GILIKGGEPLEMAHKVCRAGPGLARCVSAEAERFPLRQIQAVMFDKT-----GTLTNGVP B1AQ57_MOUSE B1AQ57_MOUSE GVLIKGGKPLEMAHK-----------------------IKTVMFDKT-----GTITHGVP ATP7B_MOUSE ATP7B_MOUSE GVLIKGGKPLEMAHK-----------------------IKTVMFDKT-----GTITHGVP B1AQ56_MOUSE B1AQ56_MOUSE GVLIKGGKPLEMAHK-----------------------IKTVMFDKT-----GTITHGVP ATP7B_RAT ATP7B_RAT GVLIKGGKPLEMAHK-----------------------IKTVMFDKT-----GTITHGVP Q9QUG4_RAT Q9QUG4_RAT GVLIKGGKPLEMAHK-----------------------IKTVMFDKT-----GTITHGVP Q9R0T2_RAT Q9R0T2_RAT GVLIKGGKPLEMAHK-----------------------IKTVMFDKT-----GTITHGVP B0EVF7_CANFA B0EVF7_CANFA GILIKGGKPLEMAHK-----------------------IKTVMFDKT-----GTITHGVP Q4U3G5_CANFA Q4U3G5_CANFA GILIKGGKPLEMAHK-----------------------IKTVMFDKT-----GTITHGVP B7ZLR2_HUMAN B7ZLR2_HUMAN --------------------------------------IKTVMFDKT-----GTITHGVP B7ZLR3_HUMAN B7ZLR3_HUMAN GILIKGGKPLEMAHK-----------------------IKTVMFDKT-----GTITHGVP B7ZLR4_HUMAN B7ZLR4_HUMAN GILIKGGKPLEMAHK-----------------------IKTVMFDKT-----GTITHGVP ATP7B_HUMAN ATP7B_HUMAN GILIKGGKPLEMAHK-----------------------IKTVMFDKT-----GTITHGVP Q17RT3_HUMAN Q17RT3_HUMAN GILIKGGKPLEMAHK-----------------------IKTVMFDKT-----GTITHGVP ATP7B_SHEEP ATP7B_SHEEP GILIKGGKPLEMAHK-----------------------IKTVMFDKT-----GTITHGVP A5A789_PIG A5A789_PIG GILIKGGKPLEMAHK-----------------------IKTVMFDKT-----GTITHGVP A5A788_PIG A5A788_PIG GILIKGGEPLEMAHK-----------------------VKVVVFDKT-----GTITHGTP ATP7A_HUMAN ATP7A_HUMAN GILIKGGEPLEMAHK-----------------------VKVVVFDKT-----GTITHGTP ATP7A_CRIGR ATP7A_CRIGR GILIKGGEPLEMAHK-----------------------VKVVVFDKT-----GTITHGTP ATP7A_RAT ATP7A_RAT GILIKGGEPLEMAHK-----------------------VKVVVFDKT-----GTITHGTP ATP7A_MOUSE ATP7A_MOUSE GILIKGGEPLEMAHK-----------------------VKVVVFDKT-----GTITHGTP B9EJ97_MOUSE B9EJ97_MOUSE GILIKGGEPLEMAHK-----------------------VKVVVFDKT-----GTITHGTP A2AG68_MOUSE A2AG68_MOUSE GILIKGGEPLEMAHK-----------------------VKVVVFDKT-----GTITHGTP A2AG69_MOUSE A2AG69_MOUSE GILIKGGEPLEMAHK-----------------------VKVVVFDKT-----GTITHGTP Q4F8H5_DANRE Q4F8H5_DANRE GILIKGGEPLEMAHK-----------------------IQSVVFDKT-----GTITYGAP Q4SJX4_TETNG Q4SJX4_TETNG GILIKGGEPLEMAHKTRFQSSE--------------SYLLSSRFSRWCLIRPGTITYGSP MATCH : *.: **:* * * CONSENSUS G?LIKGG?PLEMAHK????????????????????????K?V?FDKT?????GTITHG?P

Q4SDE7_TETNG Q4SDE7_TETNG RVTRVLVLWEPARLPLRKILALVGTAEASSEHPLGVAVAAHCR----------------- B1AQ57_MOUSE B1AQ57_MOUSE RVMRFLLLADVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCK----------------- ATP7B_MOUSE ATP7B_MOUSE RVMRFLLLADVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCK----------------- B1AQ56_MOUSE B1AQ56_MOUSE RVMRFLLLADVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCK----------------- ATP7B_RAT ATP7B_RAT RVMRFLLLVDVATLSLRKVLAVVGTAEASSEHPLGVAVTKYCK----------------- Q9QUG4_RAT Q9QUG4_RAT RVMRFLLLVDVATLSLRKVLAVVGTAEASSEHPLGVAVTKYCK----------------- Q9R0T2_RAT Q9R0T2_RAT RVMRFLLLVDVATLSLRKVLAVVGTAEASSEHPLGVAVTKYCK----------------- B0EVF7_CANFA B0EVF7_CANFA KVMRVLLLVDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCK----------------- Q4U3G5_CANFA Q4U3G5_CANFA KVMRVLLLVDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCK----------------- B7ZLR2_HUMAN B7ZLR2_HUMAN RVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCK----------------- B7ZLR3_HUMAN B7ZLR3_HUMAN RVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCK----------------- B7ZLR4_HUMAN B7ZLR4_HUMAN RVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCK----------------- ATP7B_HUMAN ATP7B_HUMAN RVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCK----------------- Q17RT3_HUMAN Q17RT3_HUMAN RVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCK----------------- ATP7B_SHEEP ATP7B_SHEEP KVSRVLLLVDLATLPLRKVLAVVGTAEASSEHPLGVAVTRYCK----------------- A5A789_PIG A5A789_PIG KVMRVLLLVDVATLPLRKVLAVVGTAEASSEHPLGVAVTRYCK----------------- A5A788_PIG A5A788_PIG VVNQVKVLVESNRISRSKILAIVGTAESNSEHPLGAAITKYCK----------------- ATP7A_HUMAN ATP7A_HUMAN VVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYCK----------------- ATP7A_CRIGR ATP7A_CRIGR VVNQVKVLVESNKIPRSKILAIVGTAESNSEHPLGAAVTKYCK----------------- ATP7A_RAT ATP7A_RAT VVNQVKVLVESNKISRNKILAIVGTAESNSEHPLGAAVTKYCK----------------- ATP7A_MOUSE ATP7A_MOUSE VVNQVKVLVESNKISRNKILAIVGTAESNSEHPLGAAVTKYCK----------------- B9EJ97_MOUSE B9EJ97_MOUSE VVNQVKVLVESNKISRNKILAIVGTAESNSEHPLGAAVTKYCK----------------- A2AG68_MOUSE A2AG68_MOUSE VVNQVKVLVESNKISRNKILAIVGTAESNSEHPLGAAVTKYCK----------------- A2AG69_MOUSE A2AG69_MOUSE VVNQVKVLVESNKISRNKILAIVGTAESNSEHPLGAAVTKYCK----------------- Q4F8H5_DANRE Q4F8H5_DANRE KVVQVKMLAEGNRLPRSKLLAIVGTAENSSEHPLGAAITKYCK----------------- Q4SJX4_TETNG Q4SJX4_TETNG EVVQVKIVVEGNKMPRSRLLAIVGTAENNSEHPLGAAITKYCKQVAFCEDGSGRPPGSAL MATCH * :. :: : :. ::**:***** .******.*:: :*: CONSENSUS ?V?????L?????????K?LA?VGTAE??SEHPLG?AVTKYCK?????????????????

Q4SDE7_TETNG Q4SDE7_TETNG ------------QELGSDLLGCCQDFQAVPGCGISCRVSNVDHLLVQE----A------- B1AQ57_MOUSE B1AQ57_MOUSE ------------EELGTETLGYSTDFQAVPGCGISCKVSNVEGILARSD----------- ATP7B_MOUSE ATP7B_MOUSE ------------EELGTETLGYSTDFQAVPGCGISCKVSNVEGILARSD----------- B1AQ56_MOUSE B1AQ56_MOUSE ------------EELGTETLGYSTDFQAVPGCGISCKVSNVEGILARSD----------- ATP7B_RAT ATP7B_RAT ------------EELGTETLGYSTDFQAVPGCGISCKVSNVESILAHRG----------- Q9QUG4_RAT Q9QUG4_RAT ------------EELGTETLGYSTDFQAVPGCGISCKVSNVESILAHRG----------- Q9R0T2_RAT Q9R0T2_RAT ------------EELGTETLGYSTDFQAVPGCGISCKVSNVESILAHRG----------- B0EVF7_CANFA B0EVF7_CANFA ------------EELGTETLGYCTDFQAVPGCGIGCKVSSVEGILAPGERQRS------- Q4U3G5_CANFA Q4U3G5_CANFA ------------EELGTETLGYCTDFQAVPGCGIGCKVSSVEGILAPGERQRS------- B7ZLR2_HUMAN B7ZLR2_HUMAN ------------EELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLS------- B7ZLR3_HUMAN B7ZLR3_HUMAN ------------EELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLS------- B7ZLR4_HUMAN B7ZLR4_HUMAN ------------EELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLS------- ATP7B_HUMAN ATP7B_HUMAN ------------EELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLS------- Q17RT3_HUMAN Q17RT3_HUMAN ------------EELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLS------- ATP7B_SHEEP ATP7B_SHEEP ------------EELGTETLGCCMDFQAVPGCGISCKVSSVESILAQGERLQG------- A5A789_PIG A5A789_PIG ------------EELGTETLGYCTDFQAVPGCGIGCKVSNVEGVLAQGERQQG------- A5A788_PIG A5A788_PIG ------------QELDTETLGTCIDFQVVPGCGISCKVTNIEGLLRKNNWKIEENNIKNS ATP7A_HUMAN ATP7A_HUMAN ------------QELDTETLGTCIDFQVVPGCGISCKVTNIEGLLHKNNWNIEDNNIKNA ATP7A_CRIGR ATP7A_CRIGR ------------QELDTETLGTCTDFQVVPGCGISCKVTNIEGLLHKSNLKIEENNTKNA ATP7A_RAT ATP7A_RAT ------------QELDTETLGTCTDFQVVPGCGISCKVTNIEGLLHKSNLKIEENNIKNA ATP7A_MOUSE ATP7A_MOUSE ------------KELDTETLGTCTDFQVVPGCGISCKVTNIEGLLHKSNLKIEENNIKNA B9EJ97_MOUSE B9EJ97_MOUSE ------------KELDTETLGTCTDFQVVPGCGISCKVTNIEGLLHKSNLKIEENNIKNA A2AG68_MOUSE A2AG68_MOUSE ------------KELDTETLGTCTDFQVVPGCGISCKVTNIEGLLHKSNLKIEENNIKNA A2AG69_MOUSE A2AG69_MOUSE ------------KELDTETLGTCTDFQVVPGCGISCKVTNIEGLLHKSNLKIEENNIKNA Q4F8H5_DANRE Q4F8H5_DANRE ------------QELGTESLGTCTDFQAVPGCGIRCLVSNTENLLKREDSDSEENQ-HNA Q4SJX4_TETNG Q4SJX4_TETNG GVLISKVILFMLQELGTESLGACTDFQAVPGCGIRCQVTNTETLLREADSDSTDNNQRNS MATCH :**.:: ** . ***.****** * *:. : :* CONSENSUS ?????????????EL?TETLG??TDFQ?VPGCGI?CKV?N?E??L???????????????

Q4SDE7_TETNG Q4SDE7_TETNG ----------SRDGSSLVPE-----QEGPGESYWVLIGNREWLRRNGHRVEADMDAAMAS B1AQ57_MOUSE B1AQ57_MOUSE -----------LTAHPVGVGNPPTGEGAGPQTFSVLIGNREWMRRNGLTISSDISDAMTD ATP7B_MOUSE ATP7B_MOUSE -----------LTAHPVGVGNPPTGEGAGPQTFSVLIGNREWMRRNGLTISSDISDAMTD B1AQ56_MOUSE B1AQ56_MOUSE -----------LTAHPVGVGNPPTGEGAGPQTFSVLIGNREWMRRNGLTISSDISDAMTD ATP7B_RAT ATP7B_RAT -----------PTAHPIGVGNPPIGEGTGPQTFSVLIGNREWMRRNGLTISSDISDAMTD Q9QUG4_RAT Q9QUG4_RAT -----------PTAHPIGVGNPPIGEGTGPQTFSVLIGNREWMRRNGLTISSDISDAMTD Q9R0T2_RAT Q9R0T2_RAT -----------PTAHPIGVGNPPIGE---------------------------------- B0EVF7_CANFA B0EVF7_CANFA ----------KQAAPPGTVGGVPEETDETPQTFSVLIGNREWMRRNGLTISSDISDAMAD Q4U3G5_CANFA Q4U3G5_CANFA ----------KQAAPPGTVGGVPEETDETPQTFSVLIGNREWMRRNGLTISSDISDAMAD B7ZLR2_HUMAN B7ZLR2_HUMAN ----------APASHLNEAGSLPAEKDAAPQTFSVLIGNREWLRRNGLTISSDVSDAMTD B7ZLR3_HUMAN B7ZLR3_HUMAN ----------APASHLNEAGSLPAEKDAAPQTFSVLIGNREWLRRNGLTISSDVSDAMTD B7ZLR4_HUMAN B7ZLR4_HUMAN ----------APASHLNEAGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTD ATP7B_HUMAN ATP7B_HUMAN ----------APASHLNEAGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTD Q17RT3_HUMAN Q17RT3_HUMAN ----------APASHLNEAGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTD ATP7B_SHEEP ATP7B_SHEEP ----------PPTAHQNRVGSEPSETDAATQTFSVLIGNREWMRRNGLTVTSDVRDAMTD A5A789_PIG A5A789_PIG ----------RPTAHLNGVSSMPSETDAAPQTFSVLIGNREWMMRNGLTVTSDVSDAMTN A5A788_PIG A5A788_PIG SLLQIDASNEQSSTSSSMIIDAHLSNGLNAQQYKVLIGNREWMIRNGLVINNDIDDSMTE ATP7A_HUMAN ATP7A_HUMAN SLVQIDASNEQSSTSSSMIIDAQISNALNAQQYKVLIGNREWMIRNGLVINNDVNDFMTE ATP7A_CRIGR ATP7A_CRIGR SLVQIDAINEQSSTSSSMIIDAPLSNAVDTQQYKVLIGNREWMIRNGLVISNDVDDSMID ATP7A_RAT ATP7A_RAT SLVQIDAINEQSSPSSSMIIDAHLSNAVNTQQYKVLIGNREWMIRNGLVISNDVDESMIE ATP7A_MOUSE ATP7A_MOUSE SLVQIDAINEQSSTSSSMIIDAHLSNAVNTQQYKVLIGNREWMIRNGLVISNDVDESMIE B9EJ97_MOUSE B9EJ97_MOUSE SLVQIDAINEQSSTSSSMIIDAHLSNAVNTQQYKVLIGNREWMIRNGLVISNDVDESMIE A2AG68_MOUSE A2AG68_MOUSE SLVQIDAINEQSSTSSSMIIDAHLSNAVNTQQYKVLIGNREWMIRNGLVISNDVDESMIE A2AG69_MOUSE A2AG69_MOUSE SLVQIDAINEQSSTSSSMIIDAHLSNAVNTQQYKVLIGNREWMIRNGLVISNDVDESMIE Q4F8H5_DANRE Q4F8H5_DANRE VLIQISDARAHSTEHPLIMDPQPL-TVVQTASYTVLIGNREWMRRNALQVRADVDEAMTE Q4SJX4_TETNG Q4SJX4_TETNG VLVQISDPHVSSCSHPLIMDPQP--QAIQTTSYVVLIGNREWMRRNCLQIRPDVEDAMAS MATCH CONSENSUS ??????????????????????????????Q???VLIGNREW??RNGL?I??D????M??

Q4SDE7_TETNG Q4SDE7_TETNG HEAKGQTAVLVAID-------GTLCAMLAVADTVKAESALAVQTLSSMGVQVVMITGDNR B1AQ57_MOUSE B1AQ57_MOUSE HEMKGQTAILVAID-------GVLCGMIAIADAVKPEAALAIYTLKSMGVDVALITGDNR ATP7B_MOUSE ATP7B_MOUSE HEMKGQTAILVAID-------GVLCGMIAIADAVKPEAALAIYTLKSMGVDVALITGDNR B1AQ56_MOUSE B1AQ56_MOUSE HEMKGQTAILVAID-------GVLCGMIAIADAVKPEAALAIYTLKSMGVDVALITGDNR ATP7B_RAT ATP7B_RAT HEMKGQTAILVAID-------GVLCGMIAIADAVKPEAALASITLKSMGVDVALITGDNR Q9QUG4_RAT Q9QUG4_RAT HEMKGQTAILVAID-------GVLCGMIAIADAVKPEAALAIYTLKSMGVDVALITGDNR Q9R0T2_RAT Q9R0T2_RAT ------------------------------------------------------------ B0EVF7_CANFA B0EVF7_CANFA HEMKGQTAILVAID-------GVLCGMIAIADAVKQEAALAVHTLKSMGVDVVLITGDNR Q4U3G5_CANFA Q4U3G5_CANFA HEMKGQTAILVAID-------GVLCGMIAIADAVKQEAALAVHTLKSMGVDVVLITGDNR B7ZLR2_HUMAN B7ZLR2_HUMAN HEMKGQTAILVAID-------GVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNR B7ZLR3_HUMAN B7ZLR3_HUMAN HEMKGQTAILVAID-------GVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNR B7ZLR4_HUMAN B7ZLR4_HUMAN HEMKGQTAILVAID-------GVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNR ATP7B_HUMAN ATP7B_HUMAN HEMKGQTAILVAID-------GVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNR Q17RT3_HUMAN Q17RT3_HUMAN HEMKGQTAILVAID-------GVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNR ATP7B_SHEEP ATP7B_SHEEP HETKGQTAILVAID-------GVLCGMIAVADSVKQEAALAVHTLKSMGVDVVLITGDNR A5A789_PIG A5A789_PIG HEMKGQTAILVAID-------GVLCGMLAIADAVKQEAALAVHTLKSMGIDVVLITGDNH A5A788_PIG A5A788_PIG HERKGRTAVLVVVD-------DELCGLIAIADTVKPEAELAVHILKSMGLEVVLMTGDNS ATP7A_HUMAN ATP7A_HUMAN HERKGRTAVLVAVD-------DELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNS ATP7A_CRIGR ATP7A_CRIGR HGRKGRPAVLVTID-------DELCGLIAIADTVKPEAELAVHILKSMGLEVVLMTGDNS ATP7A_RAT ATP7A_RAT HERRGRTAVLVTID-------DELCGLIAIADTVKPEAELAVHILKSMGLEVVLMTGDNS ATP7A_MOUSE ATP7A_MOUSE HERRGRTAVLVTID-------DELCGLIAIADTVKPEAELAVHILKSMGLEVVLMTGDNS B9EJ97_MOUSE B9EJ97_MOUSE HERRGRTAVLVTID-------DELCGLIAIADTVKPEAELAVHILKSMGLEVVLMTGDNS A2AG68_MOUSE A2AG68_MOUSE HERRGRTAVLVTID-------DELCGLIAIADTVKPEAELAVHILKSMGLEVVLMTGDNS A2AG69_MOUSE A2AG69_MOUSE HERRGRTAVLVTID-------DELCGLIAIADTVKPEAELAVHILKSMGLEVVLMTGDNS Q4F8H5_DANRE Q4F8H5_DANRE HERRGCTAVLVAVD-------NELCAMVAIADTVKPEAELAVHVLSAMGLEVVLMTGDNS Q4SJX4_TETNG Q4SJX4_TETNG HERRGCTAVLVAIDIRLNLCADTLCAMIAISDKVKPEAELAVHTLTNMGLEVVLMTGDNS MATCH CONSENSUS HE??G?TA?LV?ID?????????LCG?IAIAD?VK?EA?LA???L?SMG??V?L?TGDN?

Q4SDE7_TETNG Q4SDE7_TETNG RTAKAIAAQVGIGKVFAEVLPSHKVAKVQELQEAGLRVAMVGDGVNDSPALAQADVGIAI B1AQ57_MOUSE B1AQ57_MOUSE KTARAIATQVGINKVFAEVLPSHKVAKVQELQNEGKKVAMVGDGVNDSPALAQADVGIAI ATP7B_MOUSE ATP7B_MOUSE KTARAIATQVGINKVFAEVLPSHKVAKVQELQNEGKKVAMVGDGVNDSP