Alignment of the gene Family HBG050662 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
B0UZD1_DANRE B0UZD1_DANRE ------------------------------ B7ZR58_XENLA B7ZR58_XENLA --------MLLRVRSGNRPSETAVREELPM Q90X95_XENLA Q90X95_XENLA --------MLLRVRSGNRPSETAVREELPM Q5ZKJ1_CHICK Q5ZKJ1_CHICK ------------------------------ B4DX74_HUMAN B4DX74_HUMAN ------------------------------ Q4R5Z3_MACFA Q4R5Z3_MACFA ------------------------------ Q53F80_HUMAN Q53F80_HUMAN PDNRQPRNRQPRIRSGNEPRSASAMEP--- B2RAM8_HUMAN B2RAM8_HUMAN PDNRQPRNRQPRIRSGNEPRSAPAMEP--- A0AVN2_HUMAN A0AVN2_HUMAN PDNRQPRNRQPRIRSGNEPRSASAMEP--- BARD1_HUMAN BARD1_HUMAN PDNRQPRNRQPRIRSGNEPRSAPAMEP--- BARD1_MOUSE BARD1_MOUSE -----MPRRPPRVCSGNQPAPVPAMEP--- Q3ULG2_MOUSE Q3ULG2_MOUSE -----MPRRPPRVCSGNQPAPVPAMEP--- BARD1_RAT BARD1_RAT -----MPRRPPRVCSGNKPPPVPAMEP--- Q6J724_RAT Q6J724_RAT ------------------------------ MATCH CONSENSUS ??????????????????????????????

B0UZD1_DANRE B0UZD1_DANRE ------------------------------ B7ZR58_XENLA B7ZR58_XENLA MDEPGWERTRDALREMERKLCCSKCMFILK Q90X95_XENLA Q90X95_XENLA MDEPGWERTRDALREMERKLCCSKCMFILK Q5ZKJ1_CHICK Q5ZKJ1_CHICK -MARPWAHTRAALERLERALSCSRCAGVLR B4DX74_HUMAN B4DX74_HUMAN ------------------------------ Q4R5Z3_MACFA Q4R5Z3_MACFA ------------------------------ Q53F80_HUMAN Q53F80_HUMAN DGRGAWAHSRAALDRLEKLLRCSRCTNILR B2RAM8_HUMAN B2RAM8_HUMAN DGRGAWAHSRAALDRLEKLLRCSRCTNILR A0AVN2_HUMAN A0AVN2_HUMAN DGRGAWAHSRAALDRLEKLLRCSRCTNILR BARD1_HUMAN BARD1_HUMAN DGRGAWAHSRAALDRLEKLLRCSRCTNILR BARD1_MOUSE BARD1_MOUSE ATDGLWAHSRAALARLEKLLRCSRCANILK Q3ULG2_MOUSE Q3ULG2_MOUSE ATDGLWAHSRAALARLEKLLRCSRCANILK BARD1_RAT BARD1_RAT ATDGLWAHSRAALARLEKLLRCSRCANILR Q6J724_RAT Q6J724_RAT ------------------------------ MATCH CONSENSUS ??????????????????????????????

B0UZD1_DANRE B0UZD1_DANRE ---------------------------MFV B7ZR58_XENLA B7ZR58_XENLA DPVCLGGCEHVFCWTCVNENLGNECPLCNT Q90X95_XENLA Q90X95_XENLA DPVCLGGCEHVFCWTCVNENLGNECPLCNT Q5ZKJ1_CHICK Q5ZKJ1_CHICK EPVSLGGCEHVFCLSCMGDHVGKGCPVCHV B4DX74_HUMAN B4DX74_HUMAN ------------------------------ Q4R5Z3_MACFA Q4R5Z3_MACFA ------------------------------ Q53F80_HUMAN Q53F80_HUMAN EPVCLGGCEHIFCSNCVSDYIGTGCPVCYT B2RAM8_HUMAN B2RAM8_HUMAN EPVCLGGCEHIFCSNCVSDCIGTGCPVCYT A0AVN2_HUMAN A0AVN2_HUMAN EPVCLGGCEHIFCSNCVSDCIGTGCPVCYT BARD1_HUMAN BARD1_HUMAN EPVCLGGCEHIFCSNCVSDCIGTGCPVCYT BARD1_MOUSE BARD1_MOUSE EPVCLGGCEHIFCSGCISDCVGSGCPVCYT Q3ULG2_MOUSE Q3ULG2_MOUSE EPVCLGGCEHIFCSGCISDCVGSGCPVCYT BARD1_RAT BARD1_RAT EPVCLGGCEHIFCSGCISDCVGSGCPVCHT Q6J724_RAT Q6J724_RAT ------------------------------ MATCH CONSENSUS ??????????????????????????????

B0UZD1_DANRE B0UZD1_DANRE P----------------------------- B7ZR58_XENLA B7ZR58_XENLA PAWVRDVQVNRQLDNMIQLCAKLRNLLSMG Q90X95_XENLA Q90X95_XENLA PAWVRDVQVNRQLDNMIQLCAKLRNLLSMG Q5ZKJ1_CHICK Q5ZKJ1_CHICK PAWVQDMQINRQLDDMVQLCGKLRHLL-DA B4DX74_HUMAN B4DX74_HUMAN ------------------------------ Q4R5Z3_MACFA Q4R5Z3_MACFA ------------------------------ Q53F80_HUMAN Q53F80_HUMAN PAWIQDLKINRQLDSMIQLCSKLRNLLHDN B2RAM8_HUMAN B2RAM8_HUMAN PAWIQDLKINRQLDSMIQLCSKLRNLLHDN A0AVN2_HUMAN A0AVN2_HUMAN PAWIQDLKINRQLDSMIQLCSKLRNLLHDN BARD1_HUMAN BARD1_HUMAN PAWIQDLKINRQLDSMIQLCSKLRNLLHDN BARD1_MOUSE BARD1_MOUSE PAWILDLKINRQLDSMIQLSSKLQNLLHDN Q3ULG2_MOUSE Q3ULG2_MOUSE PAWILDLKINRQLDSMVQLSSKLQNLLHDN BARD1_RAT BARD1_RAT PAWILDLKINRQLDSMIQLYSKLQNLLHDN Q6J724_RAT Q6J724_RAT ------------------------------ MATCH CONSENSUS ??????????????????????????????

B0UZD1_DANRE B0UZD1_DANRE -----------------------NNKKNMR B7ZR58_XENLA B7ZR58_XENLA KTDENKMDLCQDTLLRLNPAQEKQKKKQIK Q90X95_XENLA Q90X95_XENLA KTDENKMDLCQDTLLRLNPAQEKQKKKQIK Q5ZKJ1_CHICK Q5ZKJ1_CHICK GTSDSMESTPTPMCSDF---GENSKKGQIK B4DX74_HUMAN B4DX74_HUMAN ------------------------------ Q4R5Z3_MACFA Q4R5Z3_MACFA ------------------------------ Q53F80_HUMAN Q53F80_HUMAN ELSDLKEDKPRKGLFN----DAGNKKNSIK B2RAM8_HUMAN B2RAM8_HUMAN ELSDLKEDKPRKSLFN----DAGSKKNSIK A0AVN2_HUMAN A0AVN2_HUMAN ELSDLKEDKPRKSLFN----DAGNKKNSIK BARD1_HUMAN BARD1_HUMAN ELSDLKEDKPRKSLFN----DAGNKKNSIK BARD1_MOUSE BARD1_MOUSE K--DSKDNTSRASLFG----DAERKKNSIK Q3ULG2_MOUSE Q3ULG2_MOUSE K--DSKDNTSRASLFG----DAERKKNSIK BARD1_RAT BARD1_RAT KGSDSKDDTSRASLFG----DAERKKNSVK Q6J724_RAT Q6J724_RAT ------------------------------ MATCH CONSENSUS ??????????????????????????????

B0UZD1_DANRE B0UZD1_DANRE IWFSPKSRKVRCCIHRPVELNTPNGVQQKK B7ZR58_XENLA B7ZR58_XENLA MWFSPRSRKVRCVVEK--KEKSQ----QIS Q90X95_XENLA Q90X95_XENLA MWFSPRSRKVRCVVEK--KEKSQ----QIS Q5ZKJ1_CHICK Q5ZKJ1_CHICK MWFSPRSRKIRCIVNK----NQP----KTN B4DX74_HUMAN B4DX74_HUMAN MWFSPRSKEVRYVVSKASVQTQP----AIK Q4R5Z3_MACFA Q4R5Z3_MACFA MWFSPRSKKVRYVVSKVSVRTQL----EIK Q53F80_HUMAN Q53F80_HUMAN MWFSPRSKKVRYVVSKASVQTQP----AIK B2RAM8_HUMAN B2RAM8_HUMAN MWFSPRSKKVRYVVSKASVQTQP----AIK A0AVN2_HUMAN A0AVN2_HUMAN MWFSPRSKKVRYVVSKASVQTQP----AIK BARD1_HUMAN BARD1_HUMAN MWFSPRSKKVRYVVSKASVQTQP----AIK BARD1_MOUSE BARD1_MOUSE MWFSPRSKKVRYVVTKVSVQTQP----QKA Q3ULG2_MOUSE Q3ULG2_MOUSE MWFSPRSKKVRYVVTKVSVQTQP----QKA BARD1_RAT BARD1_RAT MWFSPRSKKIRCVVNKVSVQTQP----QKA Q6J724_RAT Q6J724_RAT MWFSPRSKKIRCVVNKVSVQTQP----QKA MATCH :****:*:::* : : . CONSENSUS MWFSPRS?K?R?VV?K??????????????

B0UZD1_DANRE B0UZD1_DANRE STASPSSEDLAVFNFSSSSQESGPSTPPR- B7ZR58_XENLA B7ZR58_XENLA SKTLPQM-A-S-YEFVSDSPDGEPAQ--KK Q90X95_XENLA Q90X95_XENLA SKTLPQM-A-S-YEFVSDSPDGEPAQ--KK Q5ZKJ1_CHICK Q5ZKJ1_CHICK SNDLCQDPS-SVYHFFPSPVHEKPSKPRKK B4DX74_HUMAN B4DX74_HUMAN KDASAQQ-D-S-YEFVSPSPPADVSERAKK Q4R5Z3_MACFA Q4R5Z3_MACFA KDANGQQ-D-S-YEFVSTSPPADVSERAKK Q53F80_HUMAN Q53F80_HUMAN KDASAQQ-D-S-YEFVSPSPPADVSERAKK B2RAM8_HUMAN B2RAM8_HUMAN KDASAQQ-D-S-YEFVSPSPPADVSERAKK A0AVN2_HUMAN A0AVN2_HUMAN KDASAQQ-D-S-YEFVSPSPPADVSERAKK BARD1_HUMAN BARD1_HUMAN KDASAQQ-D-S-YEFVSPSPPADVSERAKK BARD1_MOUSE BARD1_MOUSE KDDKAQE-A-SMYEFVSATPPVAVPKSAKT Q3ULG2_MOUSE Q3ULG2_MOUSE KDDKAQE-A-SMYEFVSATPPVAVPKSAKT BARD1_RAT BARD1_RAT KDDKAQE-A-SVFEFVSATPPVVVSTRAKT Q6J724_RAT Q6J724_RAT KDDKAQE-A-SVFEFVSATPPVVVSTRAKT MATCH . . : :.* . . . : CONSENSUS ?????Q????S??EFVS??P????????K?

B0UZD1_DANRE B0UZD1_DANRE --AKMNKKTKKKRIGQNSRQAKAAQRPRTW B7ZR58_XENLA B7ZR58_XENLA PDPKPRKRMKKK-LKDINAEWGV--DTENE Q90X95_XENLA Q90X95_XENLA PDPKPRKRMKKK-LKDINAEWGV--DTENE Q5ZKJ1_CHICK Q5ZKJ1_CHICK PTQRQSKKMKKKRLADINKAWGL--EKPEQ B4DX74_HUMAN B4DX74_HUMAN ASARSGKKQKKKTLAEINQKWNL--EAEKE Q4R5Z3_MACFA Q4R5Z3_MACFA ASARSRKKQKKKTLAEINQKWNL--EAEKE Q53F80_HUMAN Q53F80_HUMAN ASARSGKKQKKKTLAEINQKWNL--EAEKE B2RAM8_HUMAN B2RAM8_HUMAN ASARSGKKQKKKTLAEINQKWNL--EAEKE A0AVN2_HUMAN A0AVN2_HUMAN ASARSGKKQKKKTLAEINQKWNL--EAEKE BARD1_HUMAN BARD1_HUMAN ASARSGKKQKKKTLAEINQKWNL--EAEKE BARD1_MOUSE BARD1_MOUSE ASRTSAKKHPKKSVAKINREENL--RPETK Q3ULG2_MOUSE Q3ULG2_MOUSE ASRTSAKKHPKKSVAKINREENL--RPETK BARD1_RAT BARD1_RAT ASRTSAKKHPKKSVAKINREGNF--RPETR Q6J724_RAT Q6J724_RAT ASRTSAKKHPKKSVAKINREGNF--RPETR MATCH *: ** : . . CONSENSUS ??????KK??KK????IN?????????E??

B0UZD1_DANRE B0UZD1_DANRE IRSLQE--RKKLKLEVINKQWNTGEEADVD B7ZR58_XENLA B7ZR58_XENLA IDEVSNPRKEHKSGKSV----SFCSSAVIQ Q90X95_XENLA Q90X95_XENLA IDEVSNPRKEHKSGKSV----SFCSSAVIQ Q5ZKJ1_CHICK Q5ZKJ1_CHICK KGGVEE--KA-SKEKCV----TICNEPVVL B4DX74_HUMAN B4DX74_HUMAN DGEFDS--KEESKQKLV----SFCSQPSVI Q4R5Z3_MACFA Q4R5Z3_MACFA DGEFDS--KEESKQKLV----SFCSQPSVI Q53F80_HUMAN Q53F80_HUMAN DGEFDS--KEESKQKLV----SFCSQPSVI B2RAM8_HUMAN B2RAM8_HUMAN DGEFDS--KEESKQKLV----SFCSQPSVI A0AVN2_HUMAN A0AVN2_HUMAN DGEFDS--KEESKQKLV----SFCSQPSVI BARD1_HUMAN BARD1_HUMAN DGEFDS--KEESKQKLV----SFCSQPSVI BARD1_MOUSE BARD1_MOUSE DSRFDS--KEELKEEKV----VSCSQIPVM Q3ULG2_MOUSE Q3ULG2_MOUSE DSRFDS--KEELKEEKV----VSCSQIPVM BARD1_RAT BARD1_RAT DSRFDS--KEKLKEEKV----VSFSQTLVM Q6J724_RAT Q6J724_RAT DSRFDS--KEKLKEEKV----VSFSQTLVM MATCH ... : . : : .. : CONSENSUS ????????KE??K???V???????S???V?

B0UZD1_DANRE B0UZD1_DANRE AIDETGDEDEKMSSGDDNRKPAKRVFFRLP B7ZR58_XENLA B7ZR58_XENLA HSPEVLVVESSLKNDTPEEISPNWNKCGLD Q90X95_XENLA Q90X95_XENLA HSPEVLVVESSLKNDTPEEISPNWNKCGLD Q5ZKJ1_CHICK Q5ZKJ1_CHICK CTPEQHSPKETLPQESIQEVDSTKNLVEVE B4DX74_HUMAN B4DX74_HUMAN SSPQINGEIDLLASGSLTESECFGSLTEVS Q4R5Z3_MACFA Q4R5Z3_MACFA SSPQINGEIDLLASGSLTESECFGSLTEVS Q53F80_HUMAN Q53F80_HUMAN SSPQINGEIDLLASGSLTESECFGSLTEVS B2RAM8_HUMAN B2RAM8_HUMAN SSPQINGEIDLLASGSLTESECFGSLTEVS A0AVN2_HUMAN A0AVN2_HUMAN SSPQINGEIDLLASGSLTESECFGSLTEVS BARD1_HUMAN BARD1_HUMAN SSPQINGEIDLLASGSLTESECFGSLTEVS BARD1_MOUSE BARD1_MOUSE ERPRVNGEIDLLASGSVVEPECSGSLTEVS Q3ULG2_MOUSE Q3ULG2_MOUSE ERPRVNGEIDLLASGSVVEPECSGSLTEVS BARD1_RAT BARD1_RAT ENSRVNGEIDLLASGSVVESVFSGSFAEVS Q6J724_RAT Q6J724_RAT ENLRVNGEIDLLASGSVVESECSGSFAEVS MATCH . . : . . : CONSENSUS ???????????L??????E???????????

B0UZD1_DANRE B0UZD1_DANRE HSQSEETFKP-SQQRNLTPNHEKIV-EFKD B7ZR58_XENLA B7ZR58_XENLA EPM--EMQSTSMKEVNCPSPSEQST-TLKT Q90X95_XENLA Q90X95_XENLA EPM--EMQSTSMKEVNCPSPSEQST-TLKT Q5ZKJ1_CHICK Q5ZKJ1_CHICK V-------SPEVKSSQEEDNSKAVCPVQVS B4DX74_HUMAN B4DX74_HUMAN LPLAEQIESPDTKSRNEVVTPEKVCKNYLT Q4R5Z3_MACFA Q4R5Z3_MACFA LPLAEQIESPDTKSRNEVVTPEKVCKNYLT Q53F80_HUMAN Q53F80_HUMAN LPLAEQIESPDTKSRNEVVTPEKVCKNYLT B2RAM8_HUMAN B2RAM8_HUMAN LPLAEQIESPDTKSRNEVVTPEKVCKNYLT A0AVN2_HUMAN A0AVN2_HUMAN LPLAEQIESPDTKSRNEVVTPEKVCKNYLT BARD1_HUMAN BARD1_HUMAN LPLAEQIESPDTKSRNEVVTPEKVCKNYLT BARD1_MOUSE BARD1_MOUSE LPLAEHIVSPDTVSKNEETPEKKVC----- Q3ULG2_MOUSE Q3ULG2_MOUSE LPLAEHIVSPDTVSKNEETPEKKVC----- BARD1_RAT BARD1_RAT LPLAEHIVSPDTVSKSEEAPEKKVC----- Q6J724_RAT Q6J724_RAT LPLAEHIVSPDTVSKSEEAPEKRVC----- MATCH .. . . : CONSENSUS ?P??????SP????????????????????

B0UZD1_DANRE B0UZD1_DANRE SEQQNSAALS-L-----------PDHDQQP B7ZR58_XENLA B7ZR58_XENLA QDKEKKITTVKR-----------KKHSSPI Q90X95_XENLA Q90X95_XENLA QDKEKKITTVKR-----------KKHSSPI Q5ZKJ1_CHICK Q5ZKJ1_CHICK KETNCAAEKSPSIESKAMHLKRGREQSKLP B4DX74_HUMAN B4DX74_HUMAN SKKSLPLENNGK-----------RGHHNRL Q4R5Z3_MACFA Q4R5Z3_MACFA SKKSWPLENNGK-----------RGHHNRL Q53F80_HUMAN Q53F80_HUMAN SKKSLPLENNGK-----------RGHHNRL B2RAM8_HUMAN B2RAM8_HUMAN SKKSLPLENNGK-----------RGHHNRL A0AVN2_HUMAN A0AVN2_HUMAN SKKSLPLENNGK-----------RGHHNRL BARD1_HUMAN BARD1_HUMAN SKKSLPLENNGK-----------RGHHNRL BARD1_MOUSE BARD1_MOUSE VKDLRSGGSNGN-----------RKGCHRP Q3ULG2_MOUSE Q3ULG2_MOUSE VKDLRSGGSNGN-----------RKGCHRP BARD1_RAT BARD1_RAT VEDRCPVGSDGN-----------PKGCHRP Q6J724_RAT Q6J724_RAT VEDRCPVGSDGN-----------PKGCHRP MATCH . CONSENSUS ??????????????????????????????

B0UZD1_DANRE B0UZD1_DANRE IAEISPELNENELLQPSFSRVRKRS----S B7ZR58_XENLA B7ZR58_XENLA ASSKRPRRRSS---DTSKPLNDSDIKANSP Q90X95_XENLA Q90X95_XENLA ASSKRPRRRSS---DTSKPLNDSDIKANSP Q5ZKJ1_CHICK Q5ZKJ1_CHICK GTSQTKRRRSEGSLNRNSD--SQTSCSEDL B4DX74_HUMAN B4DX74_HUMAN SSPISKRCRTS-ILSTSGDFVKQTV----P Q4R5Z3_MACFA Q4R5Z3_MACFA SSPISKRCRTS-ILSTSGDFVKQTM----P Q53F80_HUMAN Q53F80_HUMAN SSPISKRCRTS-ILSTSGDFVKQTV----P B2RAM8_HUMAN B2RAM8_HUMAN SSPISKRCRTS-ILSTSGDFVKQTV----P A0AVN2_HUMAN A0AVN2_HUMAN SSPISKRCRTS-ILSTSGDFVKQTV----P BARD1_HUMAN BARD1_HUMAN SSPISKRCRTS-ILSTSGDFVKQTV----P BARD1_MOUSE BARD1_MOUSE TTSTSDSCGSN-IPSTSRGIGEPAL----L Q3ULG2_MOUSE Q3ULG2_MOUSE TTSTSDSCGSN-IPSTSRGIGEPAL----L BARD1_RAT BARD1_RAT PTSTSKKCGSN-VPSASGEIREPTL----L Q6J724_RAT Q6J724_RAT PTSTSKKCGSN-VPSTSGEIREPTL----L MATCH : . . . CONSENSUS ????????????????S?????????????

B0UZD1_DANRE B0UZD1_DANRE SESLPKQ-PRITPEPKRRSSGEGAALIEDS B7ZR58_XENLA B7ZR58_XENLA EKACKTVSPHKPSENSAKDVRIESTQAAKR Q90X95_XENLA Q90X95_XENLA EKACKTVSPHKPSENSAKDVRIESTQAAKR Q5ZKJ1_CHICK Q5ZKJ1_CHICK SQDCPIPQVTEPRTPVQVCGSAMKTRSSAA B4DX74_HUMAN B4DX74_HUMAN SENIPLPECSSPPSCKRKVGGTSGSKNSNM Q4R5Z3_MACFA Q4R5Z3_MACFA SENTPLPECSSPPSCKRKVGGTSGRKKSNL Q53F80_HUMAN Q53F80_HUMAN SENIPLPECSSPPSCKRKVGGTSGSKNSNM B2RAM8_HUMAN B2RAM8_HUMAN SENIPLPECSSPPSCKRKVGGTSGSKNSNM A0AVN2_HUMAN A0AVN2_HUMAN SENIPLPECSSPPSCKRKVGGTSGSKNSNM BARD1_HUMAN BARD1_HUMAN SENIPLPECSSPPSCKRKVGGTSGRKNSNM BARD1_MOUSE BARD1_MOUSE AENVVLVDCSSLPSGQLQVDVTL-RRKSNA Q3ULG2_MOUSE Q3ULG2_MOUSE AENVVLVDCSSLPSGQLQVDVTL-RRKSNA BARD1_RAT BARD1_RAT AENVVLVDCSSLPSGRLQVDVTL-RRQSNA Q6J724_RAT Q6J724_RAT AENVVLVDCSSLPSGRLQVDVTL-RRQSNA MATCH : CONSENSUS ??????????????????????????????

B0UZD1_DANRE B0UZD1_DANRE SQSLKTFRPTNEKPVLSSLGTHDVLKKSPD B7ZR58_XENLA B7ZR58_XENLA DTKMCS----TPLPCAKQNNSAKLGQKSTA Q90X95_XENLA Q90X95_XENLA DTKMCS----TPLPCAKQNNSAKLGQKSTA Q5ZKJ1_CHICK Q5ZKJ1_CHICK SSPLLPKSPSTP-STFKACDQVGIPQSPSV B4DX74_HUMAN B4DX74_HUMAN SDEFISLSPGTPPSTLSSSSYRRVMSSPSA Q4R5Z3_MACFA Q4R5Z3_MACFA SDEFISLSPGTPPSTLNSSSYRRVMFSPSA Q53F80_HUMAN Q53F80_HUMAN SDEFISLSPGTPPSTLSSSSYRRVMSSPSA B2RAM8_HUMAN B2RAM8_HUMAN SDEFISLSPGTPPSTLSSSSYRRVMSSPSA A0AVN2_HUMAN A0AVN2_HUMAN SDEFISLSPGTPPSTLSSSSYRRVMSSPSA BARD1_HUMAN BARD1_HUMAN SDEFISLSPGTPPSTLSSSSYRRVMSSPSA BARD1_MOUSE BARD1_MOUSE SDDPLSLSPGTPPPLLNNSTHRQMMSSPST Q3ULG2_MOUSE Q3ULG2_MOUSE SDDPLSLSPGTPPPLLNNSTHRQMMSSPST BARD1_RAT BARD1_RAT SDDSLSLSPGTPPSLLNNSTHRQMMSKPST Q6J724_RAT Q6J724_RAT SDDSLSLSPGTPPSLLNNSTHRQMMSKPST MATCH . . . . . : ... CONSENSUS S????S??P?TP??????????????????

B0UZD1_DANRE B0UZD1_DANRE VRHKQTCPVYMKRNHKGETALHLAASKGDV B7ZR58_XENLA B7ZR58_XENLA MPISPNNLTNVKRNYKGETMLHLASIKGDI Q90X95_XENLA Q90X95_XENLA MPISPNNLTNVKRNYKGETMLHLASIKGDI Q5ZKJ1_CHICK Q5ZKJ1_CHICK FKSPGSNPIA-RRNYKGETLLHIASIKGDL B4DX74_HUMAN B4DX74_HUMAN MKLLPNMAV--KRNHRGETLLHIASIKGDI Q4R5Z3_MACFA Q4R5Z3_MACFA MKLLPNMAV--KRNHRGETLLHIASIKGDI Q53F80_HUMAN Q53F80_HUMAN MKLLPNMAV--KRNHRGETLLHIASIKGDI B2RAM8_HUMAN B2RAM8_HUMAN MKLLPNMAV--KRNHRGETLLHIASIKGDI A0AVN2_HUMAN A0AVN2_HUMAN MKLLPNMAV--KRNHRGETLLHIASIKGDI BARD1_HUMAN BARD1_HUMAN MKLLPNMAV--KRNHRGETLLHIASIKGDI BARD1_MOUSE BARD1_MOUSE VKLSSGMPAR-KRNHRGETLLHIASIKGDI Q3ULG2_MOUSE Q3ULG2_MOUSE VKLSSGMPAR-KRNHSGETLLHIASIKGDI BARD1_RAT BARD1_RAT VKLSSGIPAR-KRNHRGETLLHIASIKGDI Q6J724_RAT Q6J724_RAT VKLSSGIPAR-KRNHRGETLLHIASIK--- MATCH . :**: *** **:*: * CONSENSUS ???????????KRN??GET?LH?ASIKGD?

B0UZD1_DANRE B0UZD1_DANRE EGVRKLLAQGADPNLKDNAGWTPLHEACNV B7ZR58_XENLA B7ZR58_XENLA QGVEDLLNSGANPNVKDNAGWTPLHEACNL Q90X95_XENLA Q90X95_XENLA QGVEDLLNSGANPNVKDNAGWTPLHEACNL Q5ZKJ1_CHICK Q5ZKJ1_CHICK AAVEELLKNGADPNVKDNAGWTPLHEACNH B4DX74_HUMAN B4DX74_HUMAN PSVEYLLQNGSDPNVKDHAGWTPLHEACNH Q4R5Z3_MACFA Q4R5Z3_MACFA PSVEYLLQNGSDPNVKDHAGWTPLHEACSH Q53F80_HUMAN Q53F80_HUMAN PSVEYLLQNGSDPNVKDHAGWTPLHEACNH B2RAM8_HUMAN B2RAM8_HUMAN PSVEYLLQNGSDPNVKDHAGWTPLHEACNH A0AVN2_HUMAN A0AVN2_HUMAN PSVEYLLQNGSDPNVKDHAGWTPLHEACNH BARD1_HUMAN BARD1_HUMAN PSVEYLLQNGSDPNVKDHAGWTPLHEACNH BARD1_MOUSE BARD1_MOUSE PSVEYLLQNGNDPNVKDHAGWTPLHEACSH Q3ULG2_MOUSE Q3ULG2_MOUSE PSVEYLLQNGNDPNVKDHAGWTPLHEACSH BARD1_RAT BARD1_RAT SSVEYLLQNGNDPNVKDHAGWTPLHEACSH Q6J724_RAT Q6J724_RAT ------------------------HEACSH MATCH ****. CONSENSUS ??VE?LL??G??PNVKD?AGWTPLHEAC??

B0UZD1_DANRE B0UZD1_DANRE GHLGVVEELLQQGALLNTPGYQNDSPLHDA B7ZR58_XENLA B7ZR58_XENLA GHTMVVQLLLQHHALMNTTGYQNDTPLHDA Q90X95_XENLA Q90X95_XENLA GHTMVVQLLLQHHALMNTTGYQNDTPLHDA Q5ZKJ1_CHICK Q5ZKJ1_CHICK GHQEVVELLLQHKALVNSTGYQNDSPLHDA B4DX74_HUMAN B4DX74_HUMAN GHLKVVELLLQHKALVNTTGYQNDSPLHDA Q4R5Z3_MACFA Q4R5Z3_MACFA GHLKVVELLLQHKALVNTTGYQNDSPLHDA Q53F80_HUMAN Q53F80_HUMAN GHLKVVELLLQHKALVNTTGYQNDSPLHDA B2RAM8_HUMAN B2RAM8_HUMAN GHLKVVELLLQHKALVNTTGYQNDSPLHDA A0AVN2_HUMAN A0AVN2_HUMAN GHLKVVELLLQHKALVNTTGYQNDSPLHDA BARD1_HUMAN BARD1_HUMAN GHLKVVELLLQHKALVNTTGYQNDSPLHDA BARD1_MOUSE BARD1_MOUSE GHLKVVELLLQHNALVNTPGYQNDSPLHDA Q3ULG2_MOUSE Q3ULG2_MOUSE GHLKVVELLLQHNALVNTPGYQNDSPLHDA BARD1_RAT BARD1_RAT GHLKIVELLLQHNALVNTTGYHNDSPLHDA Q6J724_RAT Q6J724_RAT GHLKIVE-LLQHNALVNTTGYHNDSPLHDA MATCH ** :*: ***: **:*:.**:**:***** CONSENSUS GH??VVELLLQH?AL?NT?GYQNDSPLHDA

B0UZD1_DANRE B0UZD1_DANRE IRSGHIAVVKLLVERGASQSVLNIFGLRPV B7ZR58_XENLA B7ZR58_XENLA VKNGHIAIVKLLLSHGASRDAVNIFGLQPV Q90X95_XENLA Q90X95_XENLA VKNGHIAIVKLLLSHGASRDAVNIFGLQPV Q5ZKJ1_CHICK Q5ZKJ1_CHICK AKNGHVSIVELLLLHGASRDAVNIFGLRPV B4DX74_HUMAN B4DX74_HUMAN AKNGHVDIVKLLLSYGASRNAVNIFGLRPV Q4R5Z3_MACFA Q4R5Z3_MACFA AKNGHMDIVKLLLSYGASRNAVNIFGLRPV Q53F80_HUMAN Q53F80_HUMAN AKNGHVDIVKLLLSYGASRNAVNIFGLRPV B2RAM8_HUMAN B2RAM8_HUMAN AKNGHMDIVKLLLSYGASRNAVNIFGLRPV A0AVN2_HUMAN A0AVN2_HUMAN AKNGHMDIVKLLLSYGASRNAVNIFGLRPV BARD1_HUMAN BARD1_HUMAN AKNGHVDIVKLLLSYGASRNAVNIFGLRPV BARD1_MOUSE BARD1_MOUSE VKSGHIDIVKVLLSHGASRNAVNIFGVRPV Q3ULG2_MOUSE Q3ULG2_MOUSE VKSGHIDIVKVLLSHGASRNAVNIFGVRPV BARD1_RAT BARD1_RAT AKNGHIDIVKVLLSHGASRNAVNIFGERPV Q6J724_RAT Q6J724_RAT AKNGHIDIVKVLLSHGASRNAVNIFGERPV MATCH :.**: :*::*: ***:..:**** :** CONSENSUS ?K?GH??IVK?LLS?GASR?AVNIFG?RPV

B0UZD1_DANRE B0UZD1_DANRE DYALTPEMKEVLRVAP--EASHLITTSL-- B7ZR58_XENLA B7ZR58_XENLA DYAETEEMKSVLLETQTERDRLLLHPCL-- Q90X95_XENLA Q90X95_XENLA DYAETEEMKSVLLETQTERDRLLLHPCLAA Q5ZKJ1_CHICK Q5ZKJ1_CHICK DYAESEKMKSVLMLPVKNESFSFSQPS--- B4DX74_HUMAN B4DX74_HUMAN DYTDDESMKSLLLLPEKNESSSASHCSV-- Q4R5Z3_MACFA Q4R5Z3_MACFA DYTDDENMKSLLLLPEKNESSTTSHCSV-- Q53F80_HUMAN Q53F80_HUMAN DYTDDESMKSLLLLPEKNESSSASHCSV-- B2RAM8_HUMAN B2RAM8_HUMAN DYTDDESMKSLLLLPEKNESSSASHCSV-- A0AVN2_HUMAN A0AVN2_HUMAN DYTDDESMKSLLLLPEKNESSSASHCSV-- BARD1_HUMAN BARD1_HUMAN DYTDDESMKSLLLLPEKNESSSASHCSV-- BARD1_MOUSE BARD1_MOUSE DYTDNENIRSLLLLPEENESFSTSQCSI-- Q3ULG2_MOUSE Q3ULG2_MOUSE DYTDNENIRSLLLLPEENESFSTSQCSI-- BARD1_RAT BARD1_RAT DYTDAENIRSLLLLPEKTDSFSTSQCSV-- Q6J724_RAT Q6J724_RAT DYTDAENIRSLLLLPEKTDSFSTSQCSV-- MATCH **: .::.:* . . CONSENSUS DY???E???S?LL?????????????S???

B0UZD1_DANRE B0UZD1_DANRE --RPPASKAAGGVVLIGSELTQTQHKQINR B7ZR58_XENLA B7ZR58_XENLA -ALSSHQRKEEAVVLIASGLLATQRADLTK Q90X95_XENLA Q90X95_XENLA PQLSSHQRKEEAVVLIASGLLATQRADLTK Q5ZKJ1_CHICK Q5ZKJ1_CHICK --ESPSQPRDGPLGILGSGLSSKQQKLLNK B4DX74_HUMAN B4DX74_HUMAN --MNTGQRRDGPLVLIGSGLSSEQQKMLSE Q4R5Z3_MACFA Q4R5Z3_MACFA --MNIGQRRDGPLVLIGSGLSSEQQKTLSE Q53F80_HUMAN Q53F80_HUMAN --MNTGQRRDGPLVLIGSGLSSEQQKMLSG B2RAM8_HUMAN B2RAM8_HUMAN --MNTGQRRDGPLVLIGSGLSSEQQKMLSE A0AVN2_HUMAN A0AVN2_HUMAN --MNTGQRRDGPLVLIGSGLSSEQQKMLSE BARD1_HUMAN BARD1_HUMAN --MNTGQRRDGPLVLIGSGLSSEQQKMLSE BARD1_MOUSE BARD1_MOUSE --VNTGQRKNGPLVFIGSGLSSQQQKMLSK Q3ULG2_MOUSE Q3ULG2_MOUSE --VNTGQRKNGPLVFIGSGLSSQQQKMLSK BARD1_RAT BARD1_RAT -QVNTGQRKSGPLVLIGSGLSSQQQKLLSK Q6J724_RAT Q6J724_RAT -QVNTGQRKSGPLVLIGSGLSSQQQKLLSK MATCH . : ::.* * *: :. CONSENSUS ??????QR??G??V?IGSGL???Q?K?L??

B0UZD1_DANRE B0UZD1_DANRE AAQLLGGKQAKAFSSAVTHVVVPDVPIMPS B7ZR58_XENLA B7ZR58_XENLA LAKMLKASICAEYDSTVTHVIVSDEPV-LR Q90X95_XENLA Q90X95_XENLA LAKMLKASICAEYDSTVTHVIVSDEPV-LR Q5ZKJ1_CHICK Q5ZKJ1_CHICK LATVLKARRCTEFNSTVTHVVVPDVPM-PS B4DX74_HUMAN B4DX74_HUMAN LAVILKAKKYTEFDSTVTHVVVPGDAV-QS Q4R5Z3_MACFA Q4R5Z3_MACFA LAAILKAKKCTEFDSTVTHVVVPGDAV-QS Q53F80_HUMAN Q53F80_HUMAN LAVILKAKKYTEFDSTVTHVVVPGDAV-QS B2RAM8_HUMAN B2RAM8_HUMAN LAVILKAKKYTEFDSTVTHVVVPGDAV-QS A0AVN2_HUMAN A0AVN2_HUMAN LAVILKAKKYTEFDSTVTHVVVPGDAV-QS BARD1_HUMAN BARD1_HUMAN LAVILKAKKYTEFDSTVTHVVVPGDAV-QS BARD1_MOUSE BARD1_MOUSE LETVLKAKKCMEFDSTVTHVIVPDEEA-QS Q3ULG2_MOUSE Q3ULG2_MOUSE LETVLKAKKCMEFDSTVTHVIVPDEEA-QS BARD1_RAT BARD1_RAT LETVLKAKKCAEFDNTVTHVIVPDEEA-QS Q6J724_RAT Q6J724_RAT LETVLKAKKCAEFDNTVTHVIVPDEEA-QS MATCH :* . :..:****:*.. CONSENSUS L???LKA????EFDSTVTHV?VP??????S

B0UZD1_DANRE B0UZD1_DANRE TLTTLHGVLNGCWILNFSWLSCSLQAGSWV B7ZR58_XENLA B7ZR58_XENLA TMKCMMGILAGCWTLQFSWVKACLQSCNRE Q90X95_XENLA Q90X95_XENLA TMKCMMGILAGCWTLQFSWVKACLQSCNRE Q5ZKJ1_CHICK Q5ZKJ1_CHICK TVKCMMAVLSGCWVLKFEWVQACLQSTVRE B4DX74_HUMAN B4DX74_HUMAN TLKCMLGILNGCWILKFEWVKACLRRKVCE Q4R5Z3_MACFA Q4R5Z3_MACFA TLKCMLGILNGCWILKFEWVKACLRRRVCE Q53F80_HUMAN Q53F80_HUMAN TLKCMLGILNGCWILKFEWVKACLRRKVCE B2RAM8_HUMAN B2RAM8_HUMAN TLKCMLGILNGCWILKFEWVKACLRRKVCE A0AVN2_HUMAN A0AVN2_HUMAN TLKCMLGILNGCWILKFEWVKACLRRKVCE BARD1_HUMAN BARD1_HUMAN TLKCMLGILNGCWILKFEWVKACLRRKVCE BARD1_MOUSE BARD1_MOUSE TLKCMLGILSGCWILKFDWVKACLDSKVRE Q3ULG2_MOUSE Q3ULG2_MOUSE TLKCMLGILSGCWILKFDWVKACLDSKVRE BARD1_RAT BARD1_RAT TLKCMLGILNGCWVLKFDWVKACLDSQERE Q6J724_RAT Q6J724_RAT TLKCMLGILNGCWVLKFDWVKACLDSQERE MATCH *:. : .:* *** *:*.*:...* CONSENSUS T?KCM?GIL?GCW?L?F?WVKACL?????E

B0UZD1_DANRE B0UZD1_DANRE KESGYEAGDGPLRARANRGSLLPPLFDGCF B7ZR58_XENLA B7ZR58_XENLA PEESYEIPHGPHRARLNGQQMLPQLLDGCH Q90X95_XENLA Q90X95_XENLA PEESYEIPHGPHRARLNGQQMLPQLLDGCH Q5ZKJ1_CHICK Q5ZKJ1_CHICK QEEKYEIQGGPQRGRLNREQLLPKLFDGCY B4DX74_HUMAN B4DX74_HUMAN QEEKYEIPEGPRRSRLNREHCQSCLMDAT- Q4R5Z3_MACFA Q4R5Z3_MACFA QEEKYEIPEGPHRSRLNREQLLPKLFDGCY Q53F80_HUMAN Q53F80_HUMAN QEEKYEIPEGPRRSRLNREQLLPKLFDGCY B2RAM8_HUMAN B2RAM8_HUMAN QEEKYEIPEGPRRSRLNREQLLPKLFDGCY A0AVN2_HUMAN A0AVN2_HUMAN QEEKYEIPEGPRRSRLNREQLLPKLFDGCY BARD1_HUMAN BARD1_HUMAN QEEKYEIPEGPRRSRLNREQLLPKLFDGCY BARD1_MOUSE BARD1_MOUSE QEEKYEVPGGPQRSRLNREQLLPKLFDGCY Q3ULG2_MOUSE Q3ULG2_MOUSE QEEKYEVPGGPQRSRLNREQLLPKLFDGCY BARD1_RAT BARD1_RAT QEEKYEVPGGPQRSRLNREQLLPKLFDGCY Q6J724_RAT Q6J724_RAT QEEKYEVPGGPQRSRLNREQLLPKLFDGCY MATCH *. ** ** *.* * . *:*. CONSENSUS ?EE?YE?P?GP?R?RLNR?Q?LP?L?DGC?

B0UZD1_DANRE B0UZD1_DANRE FYMLGSFRKPPKDELLQLVKAGGGQLLKRL B7ZR58_XENLA B7ZR58_XENLA FYFLGCFTEHRKEDLIELVKAAGGQILIRQ Q90X95_XENLA Q90X95_XENLA FYFLGCFTEHRKEDLIELVKAAGGQILIRQ Q5ZKJ1_CHICK Q5ZKJ1_CHICK FYFLGSFNSHQKSDLVELVKAGGGQILVRQ B4DX74_HUMAN B4DX74_HUMAN -----SICGEPSNTIQRTTLLSSSLQVGAR Q4R5Z3_MACFA Q4R5Z3_MACFA FYLGGSFKHHPKDNLIKLVTAGGGQILSRK Q53F80_HUMAN Q53F80_HUMAN FYLWGTFKHHPKDNLIKLVTAGGGQILSRK B2RAM8_HUMAN B2RAM8_HUMAN FYLWGTFKHHPKDNLIKLVTAGGGQILSRK A0AVN2_HUMAN A0AVN2_HUMAN FYLWGTFKHHPKDNLIKLVTAGGGQILSRK BARD1_HUMAN BARD1_HUMAN FYLWGTFKHHPKDNLIKLVTAGGGQILSRK BARD1_MOUSE BARD1_MOUSE FFLGGNFKHHPRDDLLKLIAAAGGKVLSRK Q3ULG2_MOUSE Q3ULG2_MOUSE FFLGGNFKHHPRDDLLKLIAAAGGKVLSRK BARD1_RAT BARD1_RAT FFLGGNFKHHPKEDLLKLIAAAGGRILSRK Q6J724_RAT Q6J724_RAT FFLGGNFKHHPKEDLLKLIAAAGGRILSRK MATCH : . : . ... : CONSENSUS F???G?F??H????L??L??A?GG??L?R?

B0UZD1_DANRE B0UZD1_DANRE PKPDSDVTQTLNAAAYHAQAGSDQVLCTQY B7ZR58_XENLA B7ZR58_XENLA PKPDSDVTQTINTVAYHAEADSDQRFCTQY Q90X95_XENLA Q90X95_XENLA PKPDSDVTQTINTVAYHAEADSDQRFCTQY Q5ZKJ1_CHICK Q5ZKJ1_CHICK PKPDSDVTQTINTVAYHAESTSDQRFCTQY B4DX74_HUMAN B4DX74_HUMAN SSVESP-SQTVT------------------ Q4R5Z3_MACFA Q4R5Z3_MACFA PKPDSDVTQTINTVAYHARPDSDQRFCTQY Q53F80_HUMAN Q53F80_HUMAN PKPDSDVTQTINTVAYHARPDSDQRFCTQY B2RAM8_HUMAN B2RAM8_HUMAN PKPDSDVTQTINTVAYHARPDSDQRFCTQY A0AVN2_HUMAN A0AVN2_HUMAN PKPDSDVTQTINTVAYHARPDSDQRFCTQY BARD1_HUMAN BARD1_HUMAN PKPDSDVTQTINTVAYHARPDSDQRFCTQY BARD1_MOUSE BARD1_MOUSE PKPDSDVTQTINTVAYHAKPESDQRFCTQY Q3ULG2_MOUSE Q3ULG2_MOUSE PKPDSDVTQTINTVAYHAKPESDQRFCTQY BARD1_RAT BARD1_RAT PKPDSDVTQTINTVAYHAKPDSDQRFCTQY Q6J724_RAT Q6J724_RAT PKPDSDVTQTINTVAYHAKPDSDQRFCTQY MATCH .. :* :**:. CONSENSUS PKPDSDVTQTINTVAYHA???SDQRFCTQY

B0UZD1_DANRE B0UZD1_DANRE ILYDPQSSYKPQKVRLGKVWSAPSTWLLDC B7ZR58_XENLA B7ZR58_XENLA IVFDRASKYRPERVRQGKVWFAPSSWIIEC Q90X95_XENLA Q90X95_XENLA IVFDRASKYRPERVRQGKVWFAPSSWIIEC Q5ZKJ1_CHICK Q5ZKJ1_CHICK VIYDASSKFKPEKIRQGKVWFAPSSWIVDC B4DX74_HUMAN B4DX74_HUMAN ------------------------------ Q4R5Z3_MACFA Q4R5Z3_MACFA IIYEDLSNYHPERVRQGKVWKAPSSWFIDC Q53F80_HUMAN Q53F80_HUMAN IIYEDLCNYHPERVRQGKVWKAPSSWFIDC B2RAM8_HUMAN B2RAM8_HUMAN IIYEDLCNYHPERVRQGKVWKAPSSWFIDC A0AVN2_HUMAN A0AVN2_HUMAN IIYEDLCNYHPERVRQGKVWKAPSSWFIDC BARD1_HUMAN BARD1_HUMAN IIYEDLCNYHPERVRQGKVWKAPSSWFIDC BARD1_MOUSE BARD1_MOUSE IVYEDLFNCHPERVRQGKVWMAPSTWLISC Q3ULG2_MOUSE Q3ULG2_MOUSE IVYEDLFNCHPERVRQGKVWMAPSTWLISC BARD1_RAT BARD1_RAT IVYEDLFNCHPERVRQGKVWMAPSTWLISC Q6J724_RAT Q6J724_RAT IVYEDLFNCHPERVRQGKVWMAPSTWLISC MATCH CONSENSUS I?????????PE?VRQGKVW?APS?W???C

B0UZD1_DANRE B0UZD1_DANRE IAAFRLLPVPEP B7ZR58_XENLA B7ZR58_XENLA ITSFQLLPVH-- Q90X95_XENLA Q90X95_XENLA ITSFQLLPVH-- Q5ZKJ1_CHICK Q5ZKJ1_CHICK IMSFQLLPVK-- B4DX74_HUMAN B4DX74_HUMAN ------------ Q4R5Z3_MACFA Q4R5Z3_MACFA VMSFELLPLDS- Q53F80_HUMAN Q53F80_HUMAN VTSFELLPLDS- B2RAM8_HUMAN B2RAM8_HUMAN VMSFELLPLDS- A0AVN2_HUMAN A0AVN2_HUMAN VMSFELLPLDS- BARD1_HUMAN BARD1_HUMAN VMSFELLPLDS- BARD1_MOUSE BARD1_MOUSE IMAFELLPLDS- Q3ULG2_MOUSE Q3ULG2_MOUSE IMAFELLPLDS- BARD1_RAT BARD1_RAT VMAFELLPLDS- Q6J724_RAT Q6J724_RAT VMAFELLPLDS- MATCH CONSENSUS ???F?LLP????


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