Alignment of the gene Family HBG050682 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
B3DKL5_DANRE B3DKL5_DANRE -----------------------------------------------------MVDASTT Q6W2J8_DANRE Q6W2J8_DANRE -----------------------------------------------------MVDASTT B0JZE5_XENTR B0JZE5_XENTR ------------------------------------------------------------ BCOR_HUMAN BCOR_HUMAN LSATPLYGNVHSWMNSERVRMCGASEDRKILVNDGDASKARLELREENPLNHNVVDASTA BCOR_MOUSE BCOR_MOUSE LSATPLYGNVHSWMNSERVRMCGTSEDRKIPVNDGDASKARLELREETPLSHSVVDTSGA Q3V2W5_MOUSE Q3V2W5_MOUSE LSATPLYGNVHSWMNSERVRMCGTSEDRKIPVNDGDASKARLELREETPLSHSVVDTSGA MATCH CONSENSUS ??????????????????????????????????????????????????????VD?S??

B3DKL5_DANRE B3DKL5_DANRE CRMNPLSALGIDRTSLMRESLRVHGGMVYPPGIQTLQSEK------------GYVGDRIP Q6W2J8_DANRE Q6W2J8_DANRE CRMNPLSALGIDRTSLMRESLRVHGGMVYPPGIQTLQSEK------------GYVGDRIP B0JZE5_XENTR B0JZE5_XENTR ----------MDRTGLMQEGMRVPSGMVY-PSLCGLGSEKVREPS-GTIPGLGYVSDRNP BCOR_HUMAN BCOR_HUMAN HRIDGLAALSMDRTGLIREGLRVPGNIVY-SSLCGLGSEKGREAATSTLGGLGFSSERNP BCOR_MOUSE BCOR_MOUSE HRIDGLAALSMDRTGLIREGLRVPGNIVY-SGLCGLGSEKGREATPSSLSGLGFSSERNP Q3V2W5_MOUSE Q3V2W5_MOUSE HRIDGLAALSMDRTGLIREGLRVPGNIVY-SGLCGLGSEKGREATPSSLSGLGFSSERNP MATCH :***.*::*.:** ..:** ..: * *** *: .:* * CONSENSUS ?R???L?AL??DRT?L?RE?LRV?G??VY??????L?SEK????????????G????R?P

B3DKL5_DANRE B3DKL5_DANRE NLLYKP------DVSLDSRKTANSFVGLYKSSPPGIQKPLIVPGAGADTLGLDRRVVPGD Q6W2J8_DANRE Q6W2J8_DANRE NLLYKP------DVSLDSRKTANSFVGLYKSSPPGIQKPLIVPGAGADTLGLDRRVVPGD B0JZE5_XENTR B0JZE5_XENTR DLQYKPTAAETMDNSHMSMKQSNGFNPLFK-TPPGLQKA---PVPTSESLVMDRSA--SD BCOR_HUMAN BCOR_HUMAN EMQFKPNTPETVEASAVSGKPPNGFSAIYK-TPPGIQKS---AVATAEALGLDRPA--SD BCOR_MOUSE BCOR_MOUSE EMQFKPNTPETVEASAVSGKPPNGFSAIYK-TPPGIQKS---AVATAESLGLDRPA--SD Q3V2W5_MOUSE Q3V2W5_MOUSE EMQFKPNTPETVEASAVSGKPPNGFSAIYK-TPPGIQKS---AVATAESLGLDRPA--SD MATCH :: :** : * * * .*.* ::* :***:**. . . :::* :** . .* CONSENSUS ????KP????????S??S?K??N?F???YK??PPGIQK??????A?A??LGLDR?????D

B3DKL5_DANRE B3DKL5_DANRE KPPELSLNGGSSYLRVPSWMSPYHET---GMYPFLDSSKYAALNMYKASILSQPPPYLPQ Q6W2J8_DANRE Q6W2J8_DANRE KPPELSLNGGSSYLRVPSWMSPYHET---GMYPFLDSSKYAALNMYKASILSQPPPYLPQ B0JZE5_XENTR B0JZE5_XENTR KQNPLSVNGAN-YLRIP-WMNPYMESTSPAMYPFIDSPNKYSLNMYKAFLPQQSAYSIPQ BCOR_HUMAN BCOR_HUMAN KQSPLNINGAS-YLRLP-WVNPYMEGATPAIYPFLDSPNKYSLNMYKALLPQQS-YSLAQ BCOR_MOUSE BCOR_MOUSE KQSPLNINGAS-YLRLP-WVNPYMEGATPAIYPFLDSPNKYSLNMYKALLPQQS-YGLAQ Q3V2W5_MOUSE Q3V2W5_MOUSE KQSPLNINGAS-YLRLP-WVNPYMEGATPAIYPFLDSPNKYSLNMYKALLPQQS-YGLAQ MATCH * *.:**.. ***:* *:.** * .:***:**.: :****** : .*. :.* CONSENSUS K???L??NG?S?YLR?P?W??PY?E??????YPFLDS?????LNMYKA????Q????L?Q

B3DKL5_DANRE B3DKL5_DANRE HLAYQSLCAGAGGSVAGTERLFYMP--TYPPAPISSPLAPPLRIPPATVAPTTLSPMMHH Q6W2J8_DANRE Q6W2J8_DANRE HLAYQSLCAGAGGSVAGTERLFYMP--TYPPAPISSPLAPPLRIPPATVAPTTLSPMMHH B0JZE5_XENTR B0JZE5_XENTR HLAYSPVCPNG-------ERFVYIPPSHYVGPHIASGLAPSIKIPPPSATP-AIPTSVHC BCOR_HUMAN BCOR_HUMAN PL-YSPVCTNG-------ERFLYLPPPHYVGPHIPSSLASPMRLSTPSASP-AIPPLVHC BCOR_MOUSE BCOR_MOUSE PL-YSPVCTSG-------ERFLYLPPPHYVNPHIPSSLASPMRLSTPSASA-AIPPLVHC Q3V2W5_MOUSE Q3V2W5_MOUSE PL-YSPVCTSG-------ERFLYLPPPHYVNPHIPSSLASPMRLSTPSASA-AIPPLVHC MATCH * *..:*... **:.*:* * . *.* **..:::...:.:. ::.. :* CONSENSUS ?L?Y???C??????????ER??Y?P???Y????I?S?LA?P?R????????????P??H?

B3DKL5_DANRE B3DKL5_DANRE QDKTVQSIGPRIHHEPSAFGQQTIHQHTQPHHQSPIDRQHSSSGNSSSNSKSIRTSSSKN Q6W2J8_DANRE Q6W2J8_DANRE QDKTVQSIGPRIHHEPSAFGQQTIHQHTQPHHQSPIDRQHSSSGNSSSNSKSIRTSSSKN B0JZE5_XENTR B0JZE5_XENTR LEKNLPW---KMGVSPG----SAVDSHAYSHLP---------------NSKQPRVTCVKS BCOR_HUMAN BCOR_HUMAN ADKSLPW---KMGVSPG----NPVDSHAYPHIQ---------------NSKQPRVPSAKA BCOR_MOUSE BCOR_MOUSE SDKSLPW---KMGVNPG----NPVDSHSYPHIQ---------------NSKQPRVTSAKA Q3V2W5_MOUSE Q3V2W5_MOUSE SDKSLPW---KMGVNPG----NPVDSHSYPHIQ---------------NSKQPRVTSAKA MATCH :*.: :: .*. ..:..*: .* ***. *... * CONSENSUS ?DK????????????P??????????H??PH?Q???????????????NSK??R??S?K?

B3DKL5_DANRE B3DKL5_DANRE LSSTSSIVSSSAGISSCTSSIVSVDSCPSLVMQPPRPTPRPPQPPAAPPPPLMDSTMEFQ Q6W2J8_DANRE Q6W2J8_DANRE LSSTSSIVSSSAGISSCTSSIVSVDSCPSLVMQPPRPTPRPPQPPAAPPPPLMDSTMEFQ B0JZE5_XENTR B0JZE5_XENTR TTG-------------------NISPEPALLLN---PSQRPSSRLHCPVQQVGDSFSEFQ BCOR_HUMAN BCOR_HUMAN VTS-------------------GLPGDTALLLP---PSPRPSPRVHLPTQPAADTYSEFH BCOR_MOUSE BCOR_MOUSE VNS-------------------GLPGDTALLLP---PSPRPSARVHLPTQPAAETYSEFH Q3V2W5_MOUSE Q3V2W5_MOUSE VNS-------------------GLPGDTALLLP---PSPRPSARVHLPTQPAAETYSEFH MATCH .. .: .:*:: *: **. * :: **: CONSENSUS ??S??????????????????????????L??????P?PRP??????P??P??????EF?

B3DKL5_DANRE B3DKL5_DANRE KPLYRSPSSSSSSSP-SVSHPVYISSASQELRSPIRSSGQKPKAKEATMESTRGMGNERK Q6W2J8_DANRE Q6W2J8_DANRE KPLYRSPSSSSSSSP-SVSHPVYISSASQELRSPIRSSGQKPKAKEATMESTRGMGNERK B0JZE5_XENTR B0JZE5_XENTR TPFAKIP-----TPPTSIVHSKPLCNVSNDFTPLRIPNIKVHKNHEPEIAQVQAPLKKNR BCOR_HUMAN BCOR_HUMAN KHYARIS-----TSP-SVALSKPYMTVSSEFPAARLSNGKYPKAPEGGEGAQPVPGHARK BCOR_MOUSE BCOR_MOUSE KHYPRIS-----TSP-SVTLTKPYMTANSEFSTSRLSNGKYPKALDGGDCAQSMPGHTRK Q3V2W5_MOUSE Q3V2W5_MOUSE KHYPRIS-----TSP-SVTLTKPYMTANSEFSTSRLSNGKYPKALDGGDCAQSMPGHTRK MATCH . : . :.* *: . ....:: . .. : * : : .: CONSENSUS K???R????????SP?SV???????????E??????S?G??PKA???????????G??RK

B3DKL5_DANRE B3DKL5_DANRE GSSSPVKTSSDKS-PQQGPITKDPADKPLDLSAKIMEFEGHTNGYPSKLEALAKLGYSPA Q6W2J8_DANRE Q6W2J8_DANRE GSSSPVKTSSDKS-PQQGPITKDPADKPLDLSAKIMEFEGHTNGYPSKLEALAKLGYSPA B0JZE5_XENTR B0JZE5_XENTR ----DRKESKSPVLVQKQMPHKDGGEKPLDLSSKFGDADISKVECTEN-APSILHLASHV BCOR_HUMAN BCOR_HUMAN TAVQDRKDGSSPPLLEKQTVTKDVTDKPLDLSSKVVDVDASKADHMKKMAPTVLVHSRAG BCOR_MOUSE BCOR_MOUSE TTVQDRKDGGSPPLLEKQTVTKDVTDKPLDLSSKVVDADASKGDHMKKMAPTVLVHSRAA Q3V2W5_MOUSE Q3V2W5_MOUSE TTVQDRKDGGSPPLLEKQTVTKDVTDKPLDLSSKVVDADASKGDHMKKMAPTVLVHSRAA MATCH * . . :: ** :******:*. : : . .: . CONSENSUS ??????K?????????????TKD??DKPLDLS?K?????????????K????????????

B3DKL5_DANRE B3DKL5_DANRE ARYGLPPNRELLKETLSPSSSAVSTSKTPERPEIISTLPSSWVVPSPTQTISSEASQNKG Q6W2J8_DANRE Q6W2J8_DANRE ARYGLPPNRELLKETLSPSSSAVSTSKTPERPEIISTLPSSWVVPSPTQTISSEASQNKG B0JZE5_XENTR B0JZE5_XENTR NTMGL-SSRDAHKEAISPPTNSSGIV----RPEIISTAASSWVVPGITHT-----EETNG BCOR_HUMAN BCOR_HUMAN SGLVL-SGSEIPKETLSPPGNGCAIY----RSEIISTAPSSWVVPGPSPN-----EENNG BCOR_MOUSE BCOR_MOUSE SGLVL-SGSEIPKETLSPPGNGCSIY----RSEIISTAPSSWVVPGPSPN-----EENNG Q3V2W5_MOUSE Q3V2W5_MOUSE SGLVL-SGSEIPKETLSPPGNGCSIY----GSEIISTAPSSWVVPGPSPN-----EENNG MATCH * .. : **::**. .. . .***** .******. : . .:.:* CONSENSUS ????L????E??KETLSP????????????R?EIIST?PSSWVVP?P??????????N?G

B3DKL5_DANRE B3DKL5_DANRE SSI-IKNKNLENVVPQSRSSSCPKVDDQNNGSVSSSAPIIITSTSRPSSVSPSP--KMNG Q6W2J8_DANRE Q6W2J8_DANRE SSI-IKNKNLENVVPQSRSSSCPKVDDQNNGSVSSSAPIIITSTSRPSSVSPSP--KMNG B0JZE5_XENTR B0JZE5_XENTR IIMSLKNKTLERVMPQQRSSSCPRMGSSE--SVVCSNPGIVPAMGRPASASPAP--NANA BCOR_HUMAN BCOR_HUMAN KSMSLKNKALDWAIPQQRSSSCPRMGGTD--AVITNVSGSVSSAGRPASASPAP--NANA BCOR_MOUSE BCOR_MOUSE KSLSLKNKALDWAIPQQRSSSCPRMGGTD--AVVTNVSGSVSSSGRPASASPAPNANANA Q3V2W5_MOUSE Q3V2W5_MOUSE KSLSLKNKALDWAIPQQRSSSCPRMGGTD--AVVTNVSGSVSSSGRPASASPAPNANANA MATCH : :*** *: .:**.******::.. : :* . . :.: .**:*.**:* : *. CONSENSUS ?S???KNK?L????PQ?RSSSCP?????????V?????????S??RP?S?SP?P????N?

B3DKL5_DANRE B3DKL5_DANRE DWAKSVPTPPEKTP-INNHSGSHSSATKP-----SKTAKKTETPDIGFKPQQSHLENGHT Q6W2J8_DANRE Q6W2J8_DANRE DWAKSVPTPPEKTP-INNHSGSHSSATKP-----SKTAKKTETPDIGFKPQQSHLENGHT B0JZE5_XENTR B0JZE5_XENTR E----VRNPEDCNKSVIQQVPTSVSTSVK-----NSRAVKSSVPESTMKVN----ENSMP BCOR_HUMAN BCOR_HUMAN DGTKTSRSSVETTPSVIQHVGQPPATPAKHSSSTSSKGAKASNPEPSFKAN----ENGLP BCOR_MOUSE BCOR_MOUSE DGTKTSRSSVDTTPSVIQHVGQPSSTPAKHGGSTSSKGAKA-NPEPSFKAS----ENGLP Q3V2W5_MOUSE Q3V2W5_MOUSE DGTKTSRSSVDTTPSVIQHVGQPSSTPAKHGGSTSSKGAKA-NPEPSFKAS----ENGLP MATCH : .. : . : :: ::. .. . *: *: :* . **. . CONSENSUS D??K????????TP????H?G???S?????????S????K???P???FK??????ENG??

B3DKL5_DANRE B3DKL5_DANRE PSH-LYMQQGETYLSPGLAYSSRYLSYPVPESLSLSHLQLSGKGPVYPHPVLLGANSLYS Q6W2J8_DANRE Q6W2J8_DANRE PSH-LYMQQGETYLSPGLAYSSRYLSYPVPESLSLSHLQLSGKGPVYPHPVLLGANSLYS B0JZE5_XENTR B0JZE5_XENTR PAAPMFVHQSEPFCSPPLAYPSSFIPYQVSETLALSHLHLHNKAPVYPHPVLLSNGSLFP BCOR_HUMAN BCOR_HUMAN PSS-IFLSPNEAFRSPPIPYPRSYLPYPAPEGIAVSPLSLHGKGPVYPHPVLLPNGSLFP BCOR_MOUSE BCOR_MOUSE PTS-IFLSPNEAFRSPAIPYPRSYLPYAAPEGIALSPLSLHGKGPVYPHPVLLPNGSLFP Q3V2W5_MOUSE Q3V2W5_MOUSE PTS-IFLSPNEAFRSPAIPYPRSYLPYAAPEGIALSPLSLHGKGPVYPHPVLLPNGSLFP MATCH *: ::: .*.: ** :.*. ::.* ..* :::* * * .*.********* .**:. CONSENSUS P?????????E???SP???Y???YL?Y??PE???LS?L?L?GKGPVYPHPVLL???SL??

B3DKL5_DANRE B3DKL5_DANRE TRLPPKPGIPFGIPPNHAEYLTYHDS--QEMVHPLMSPHLPLDHKVTERLDLRPRTLDKT Q6W2J8_DANRE Q6W2J8_DANRE TRLPPKPGIPFGIPPNHAEYLTYHDS--QEMVHPLMSPHLPLDHKVTERLDLRPRTLDKT B0JZE5_XENTR B0JZE5_XENTR GPMAPKPGIPYSMPTNR-DYMTYQDT--LGMVHPILLPPTTIEMSKDGQ-ERRSRSHERP BCOR_HUMAN BCOR_HUMAN GHLAPKPGLPYGLPTGRPEFVTYQDALGLGMVHPMLIPHTPIEITKEEKPERRSRSHERA BCOR_MOUSE BCOR_MOUSE GHLAPKPGLPYGLHTSRPEFVTYQDALGLGMVHPMLIPHTPIEITKEEKPERRSRSHERA Q3V2W5_MOUSE Q3V2W5_MOUSE GHLAPKPGLPYGLHTSRPEFVTYQDALGLGMVHPMLIPHTPIEITKEEKPERRSRSHERA MATCH :.****:*:.: ..: :::**:*: ****:: * .:: . : : *.*: ::. CONSENSUS ??L?PKPG?P?G??????E??TY?D?????MVHP???PH?P??????E????R?R?????

B3DKL5_DANRE B3DKL5_DANRE WHHDEPPYKRQ------SITDIDPDYKSEKESERQEVLG-SKSLSKPHTVNKDEIVCIDL Q6W2J8_DANRE Q6W2J8_DANRE WHHDEPPYKRQ------SITDIDPDYKSEKESERQEVLG-SKSLSKPHTVNKDEIVCIDL B0JZE5_XENTR B0JZE5_XENTR RYDDSPPRSRLLDISD-SSSKLSFEIPADKALKVHHG---SRHVSKP-----EKLS---- BCOR_HUMAN BCOR_HUMAN RYEDPTLRNRFSEILETSSTKLHPDVPTDKNLKPNPNWNQGKTVVKS-----DKLVYVDL BCOR_MOUSE BCOR_MOUSE RYEDPTLRSRFSEMLEASSTKLHPEVPTDKNLKPNSSWNQGKTGVKS-----DKLVYVDL Q3V2W5_MOUSE Q3V2W5_MOUSE RYEDPTLRSRFSEMLEASSTKLHPEVPTDKNLKPNSSWNQGKTGVKS-----DKLVYVDL MATCH :.* . .* * :.: : ::* : : .: *. ::: CONSENSUS ???D?????R???????S?T???P?????K???????????K???K??????D??V??DL

B3DKL5_DANRE B3DKL5_DANRE VQDDTDGSPEPDKHSTIDAKCKEPAKPVGSGTGMGNESGSNSEGKEPELMQILRSGQPAV Q6W2J8_DANRE Q6W2J8_DANRE VQDDTDGSPEPDKHSTIDAKCKEPAKPVGSGTGMGNESGSNSEGKEPELMQILRSGQPAV B0JZE5_XENTR B0JZE5_XENTR TNAERDA-----KCNTN-----LAVKLKTNDVTVEKPEQG---LQNRDLIT-REEIQRTN BCOR_HUMAN BCOR_HUMAN LREEPDA-----KTDTNVSKPSFAAESVGQSAEPPKPSVEPALQQHRDFIALREELGRIS BCOR_MOUSE BCOR_MOUSE LREEADT-----KTDAGAPKAGLVAENVGQDTEATKPSADPVIQQRREFISLREELGRIT Q3V2W5_MOUSE Q3V2W5_MOUSE LREEADT-----KTDAGAPKAGLVAENVGQDTEATKPSADPVIQQRREFISLREELGRIT MATCH . : * * .: .: ... : . :. ::: .. CONSENSUS ?????D??????K??????K????A??VG????????S??????????????????????

B3DKL5_DANRE B3DKL5_DANRE SWPTDSEQRAEVCSPPRPHKQSDSPLHSQSEESSSEHSPLPDMLEEQTLRCARTSGERAR Q6W2J8_DANRE Q6W2J8_DANRE SWPTDSEQRAEVCSPPRPHKQSDSPLHSQSEESSSEHSPLPDMLEEQTLRCARTSGERAR B0JZE5_XENTR B0JZE5_XENTR EFHRSFQVSRPTLESPVFHYRQESPLGNQNADCSAAEACARFLAPPESNDVPVGHFSRGQ BCOR_HUMAN BCOR_HUMAN DFHETYTFKQ-----PVFTVSKDSVLAGTNKENLGLPVSTPFLEPPLGSDGPAVTFGKTQ BCOR_MOUSE BCOR_MOUSE DFHESFTFKQASSQ-PVFSLGKDSGAAGTNKENLGVQVATPFLETALGSEGPAVTFGKTQ Q3V2W5_MOUSE Q3V2W5_MOUSE DFHESFTFKQASSQ-PVFSLGKDSGAAGTNKENLGVQVATPFLETALGSEGPAVTFGKTQ MATCH .: * .:* . . : . : . : : CONSENSUS ???????????????P??????DS???????E????????P???????????????????

B3DKL5_DANRE B3DKL5_DANRE ADGAEFRVDRHHTNRQYVD-LGKDGLEDTESHEDEEEGHGCSKGKRSSLAKRIANSSGYV Q6W2J8_DANRE Q6W2J8_DANRE ADGAEFRVDRHHTNRQYVD-LGKDGLEDTESHEDEEEGHGCSKGKRSSLAKRIANSSGYV B0JZE5_XENTR B0JZE5_XENTR EKSQPFLGSNGHSDIEMIDSLGRDAADEFETINGK-----LVKTKSSKLTKRIANSAGYV BCOR_HUMAN BCOR_HUMAN EDPKPFCVGSAPPSVDVTPTYTKDGADEAESNDGK-----VLKPKPSKLAKRIANSAGYV BCOR_MOUSE BCOR_MOUSE EDPKPFCVGGAPPNMDVTPAYTKEGTDEAESNDGK-----VLKPKPSKLAKRIANSAGYV Q3V2W5_MOUSE Q3V2W5_MOUSE EDPKPFCVGGAPPNMDVTPAYTKEGTDEAESNDGK-----VLKPKPSKLAKRIANSAGYV MATCH . * . .. : ::. :: *: :.: * * *.*:******:*** CONSENSUS ?D???F?V??????????????K?G????ES???????????K?K?S?LAKRIANS?GYV

B3DKL5_DANRE B3DKL5_DANRE GDRFKCVTTELYADSSKLSREQRALQMEGLSQEDSNLSQPAAFWERAMMRFSELELKEKE Q6W2J8_DANRE Q6W2J8_DANRE GDRFKCVTTELYADSSKLSREQRALQ-------------------RAMMRFSELELKEKE B0JZE5_XENTR B0JZE5_XENTR GDRFKCVTTELYADSSQLSREQRALQIEGL-EEDSILSPPAAYCERAMMRFSELEMKAQE BCOR_HUMAN BCOR_HUMAN GDRFKCVTTELYADSSQLSREQRALQMEGL-QEDSILCLPAAYCERAMMRFSELEMKERE BCOR_MOUSE BCOR_MOUSE GDRFKCVTTELYADSSQLSREQRALQMEGL-QEDSILCLPAAYCERAMMRFSELEMKERE Q3V2W5_MOUSE Q3V2W5_MOUSE GDRFKCVTTELYADSSQLSREQRALQ-------------------RAMMRFSELEMKERE MATCH ****************:********* **********:* :* CONSENSUS GDRFKCVTTELYADSS?LSREQRALQ???????????????????RAMMRFSELE?KE?E

B3DKL5_DANRE B3DKL5_DANRE GCVSSAAPGLGREQERERELAESQHGAGDWERSQPSSRPSAALSALSDSTEQRNGTTPAC Q6W2J8_DANRE Q6W2J8_DANRE GCVSSAAPGLGREQERERELAESQHGAGDWERSQPSSRPSAALSALSDSTEQRNGTTPAC B0JZE5_XENTR B0JZE5_XENTR ------------EHMPSKDSESCK-NVTEWEELKP---------AVAKPVVEHSGNIQME BCOR_HUMAN BCOR_HUMAN G-----------GHPATKDSEMCKFSPADWERLKGNQDKKPKSVTLEEAIAEQNESERCE BCOR_MOUSE BCOR_MOUSE G-----------SHPATKDSEVCKFSPADWERLKGNQEKKPKSVTLEEAIADQNDSERCE Q3V2W5_MOUSE Q3V2W5_MOUSE G-----------SHPATKDSEVCKFSPADWER---------------------------- MATCH : :: .: . :**. CONSENSUS G???????????????????????????DWER????????????????????????????

B3DKL5_DANRE B3DKL5_DANRE ANNRVPVLQRCGLPADVLQPHRTEEKRARDVKGEE--EGSVGTATGRKRALGLEHSQGHP Q6W2J8_DANRE Q6W2J8_DANRE ANNRVPVLQRCGLPADVLQPHRTEEKRARDVKGEE--EGSVGTATGRKRALGLEHSQGHP B0JZE5_XENTR B0JZE5_XENTR ---GLEKSTLVNMDEIAKYPEREYLKRDCHFERMNLYEEAVLPTDNFSQRHCLSIKRKHP BCOR_HUMAN BCOR_HUMAN YSVGNKHRDPFEAPEDKDLPVEKYFVERQPVSEPP--ADQVASDMPHSPTLRVDRKRKVS BCOR_MOUSE BCOR_MOUSE YSTGNKH-DLFEAPEDKDLPVEKYFLERPPVSEPP--SDQGVVDTPHSPTLRLDRKRKLS Q3V2W5_MOUSE Q3V2W5_MOUSE ------------------------------------------------------------ MATCH CONSENSUS ???????????????????P????????????????????????????????????????

B3DKL5_DANRE B3DKL5_DANRE DCTHTTEERDGERPTRGEEDNGIASKRARLISDVWP-------------QPSEQEVKKLK Q6W2J8_DANRE Q6W2J8_DANRE DCTHTTEERDGERPTRGEEDNGIASKRARLISDVWP-------------QPSEQEVKKLK B0JZE5_XENTR B0JZE5_XENTR EDIQ-PEEFLHSLTTEEALREETQAKRKKI--DDYCGNDLVDCSSKALAESHSNEVTNLK BCOR_HUMAN BCOR_HUMAN GDSSHTETTAEEVP----EDPLLKAKRRRVSKDDWPEREMTNSSSNHLEDPHYSELTNLK BCOR_MOUSE BCOR_MOUSE GDSTHTETAVEELA-----EDPLKAKRRRISKDDWPEREMTNSSSNHLEDPHCNELTNLK Q3V2W5_MOUSE Q3V2W5_MOUSE ------------------------------------------------------------ MATCH CONSENSUS ??????E??????????????????KR?????D?????????????????????E???LK

B3DKL5_DANRE B3DKL5_DANRE VRIELTGLRLSKPRHLHNLQELWDRQGQLNHDRPQFGATNLGLPSTSKASIPPLQTTRRE Q6W2J8_DANRE Q6W2J8_DANRE VRIELTGLRLSKPRHLHNLQELWDRQGQLNHDRPQFGATNLGLPPTSKASIPPLQTTRRE B0JZE5_XENTR B0JZE5_XENTR VCIELTGLHPKKQRHLQHLREL-------------------GQQCRRDSSEIRVVSETEN BCOR_HUMAN BCOR_HUMAN VCIELTGLHPKKQRHLLHLRERWEQQVSAADGKP-------GRQSRKEVTQA-TQPEAIP BCOR_MOUSE BCOR_MOUSE VCIELTGLHPKKQRHLLHLRERWEQQVSAAESKP-------GRQSRKEVAQA-VQPEVTS Q3V2W5_MOUSE Q3V2W5_MOUSE ------------------------------------------------------------ MATCH CONSENSUS V?IELTGL???K?RHL??L?E????????????????????G??????????????????

B3DKL5_DANRE B3DKL5_DANRE KLDPCTPEVPRVAHGVPAVDRKVKTNGIEEKGLKRKAEVE--RGWTKEQLEYAESNTAIP Q6W2J8_DANRE Q6W2J8_DANRE KLDPCTPEVPRVAHGVPAVDRKVKTNGIEEKGLKRKAEVE--RGWTKEQLEYAESNTAIP B0JZE5_XENTR B0JZE5_XENTR KLRPWE----------------------EEQSIKKKPESKCTSGLESIKTDIPEEDTSVP BCOR_HUMAN BCOR_HUMAN QGTNIT----------------------EEKPGRKRAEAKGNRSWSEESLKPSDNEQGLP BCOR_MOUSE BCOR_MOUSE QGTNIT----------------------EEKPGRKKAEAKGNRGWSEESLKSCDNEQGLP Q3V2W5_MOUSE Q3V2W5_MOUSE ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????EE???????E?????????????????????P

B3DKL5_DANRE B3DKL5_DANRE ALS-----DSFCSDSI----RKFSSAVPPHHLSDKRQRLKEHRKSVGSSSPSPDPDCTFP Q6W2J8_DANRE Q6W2J8_DANRE ALS-----DSFCSDSI----RKFSSAVPPHHLSDKRQRLKEHRKSVGSSSPSPDPDCTFP B0JZE5_XENTR B0JZE5_XENTR LHP-----KGFTSGCPSSKQQNQTHSTLVPRLGSKQQKIRDGRKS-NVQNADEEGGLQDT BCOR_HUMAN BCOR_HUMAN VFSGSPPMKSLSSTSAGGKKQAQPSCAPASRPPAKQQKIKENQKT-DVLCADEEEDCQAA BCOR_MOUSE BCOR_MOUSE VLSGSPPMKSLSSTNASGKKQTQPSCTPASRLPAKQQKIKESQKT-DVLCTGEDEDCQAA Q3V2W5_MOUSE Q3V2W5_MOUSE ------------------------------------------------------------ MATCH CONSENSUS ????????????S?????????????????????K?Q??????K????????????????

B3DKL5_DANRE B3DKL5_DANRE GRLRRHGD-PEKPKGKRQCKTKHLSQQERRM-LLQSTNQECPELSPAHQHKVVKCSAQKR Q6W2J8_DANRE Q6W2J8_DANRE GRLRRHGD-PEKPKGKRQCKTKHLSQQERRM-LLQSTNQECPELSPAHQHKVVKCSAQKR B0JZE5_XENTR B0JZE5_XENTR SLLEDYTD-CEKPSGKRQCKTKHLAPQERRRKKLSVSGDD------STDEKVVLRGHKKH BCOR_HUMAN BCOR_HUMAN SLLQKYTDNSEKPSGKRLCKTKHLIPQESRR-GLPLTGEYYVE---NADGKVTVRRFRKR BCOR_MOUSE BCOR_MOUSE SPLQKYTDNIEKPSGKRLCKTKHLIPQESRR-SLQITGDYYVE---NTDTKMTVRRFRKR Q3V2W5_MOUSE Q3V2W5_MOUSE ------------------------------------------------------------ MATCH CONSENSUS ??L????D??EKP?GKR?CKTKHL??QE?R???L????????????????K???????K?

B3DKL5_DANRE B3DKL5_DANRE PALLSNYESSPIKPHPPSPAYQPAASPTPPCAVADVPVPPLAPAPPVSAEPPVNRPMPPE Q6W2J8_DANRE Q6W2J8_DANRE PALLSNYESSPIKPHPPSPAYQPAASPTPPCAVADVPVPPLAPAPPVSAEPPVNRPMPPE B0JZE5_XENTR B0JZE5_XENTR AEGSS--DDSPVKTQ---------EQMAPAIQTPSLSL----PLPNTVQEATPSRPMPPE BCOR_HUMAN BCOR_HUMAN PEPSSDYDLSPAKQE-PKP-FDRLQQLLPASQSTQL------PCSSSPQETTQSRPMPPE BCOR_MOUSE BCOR_MOUSE PEPSSDYDLSPPAKQEPKP-FDRLQQLLPATQATQL------PRSNSPQETTQSRPMPPE Q3V2W5_MOUSE Q3V2W5_MOUSE ------------------------------------------------------------ MATCH CONSENSUS ????S????SP?????????????????P?????????????P??????E????RPMPPE

B3DKL5_DANRE B3DKL5_DANRE ARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKVCDVNHRDNAGYCALHEACSRGWLSI Q6W2J8_DANRE Q6W2J8_DANRE ARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKVCDVNHRDNAGYCALHEACSRGWLSI B0JZE5_XENTR B0JZE5_XENTR ARRLIVNKNAGETLLQRAARLGYEEVVLYCLESKSCDVNHRDNAGYCALHEACARGWLSI BCOR_HUMAN BCOR_HUMAN ARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNI BCOR_MOUSE BCOR_MOUSE ARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKVCDVNHRDNAGYCALHEACARGWLNI Q3V2W5_MOUSE Q3V2W5_MOUSE ------------------------------------------------------------ MATCH CONSENSUS ARRLIVNKNAGETLLQRAARLGYEEVVLYCLE?K?CDVNHRDNAGYCALHEAC?RGWL?I

B3DKL5_DANRE B3DKL5_DANRE VQHLLEHGADINCSAQDGTRPLHDAVENDHLDVVRLLLSYGADPTLATYSGRGLLKMTHS Q6W2J8_DANRE Q6W2J8_DANRE VQHLLEHGADINCSAQDGTRPLHDAVENDHLDVVRLLLSYGADPTLATYSGRGLLKMTHS B0JZE5_XENTR B0JZE5_XENTR VRHLLEHGADVNCSAQDGTRPIHDAVENDHLEIVRLLLSYGADPTLATYSGRTIAKMTHS BCOR_HUMAN BCOR_HUMAN VRHLLEYGADVNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTHS BCOR_MOUSE BCOR_MOUSE VRHLLEYGADVNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTHS Q3V2W5_MOUSE Q3V2W5_MOUSE ------------------------------------------------------------ MATCH CONSENSUS V?HLLE?GAD?NCSAQDGTRP?HDAVENDHL??VRLLLSYGADPTLATYSGR???KMTHS

B3DKL5_DANRE B3DKL5_DANRE DIMECFLSDYFADLQGRVDDDPSVYWEFYGSAVCEPADDSSGYDILANPPGP---GEDED Q6W2J8_DANRE Q6W2J8_DANRE DIMECFLSDYFADLQGRVDDDPSVYWEFYGSAVCEPADDSSGYDILANPPGP---GEDED B0JZE5_XENTR B0JZE5_XENTR EAMETFLTEYLTDLQGRSCDDPGLSWDFYGSSVCDL-KEESGFDILANPPGP---DEEDD BCOR_HUMAN BCOR_HUMAN ELMEKFLTDYLNDLQGRNDDDASGTWDFYGSSVCEP-DDESGYDVLANPPGPEDQDDDDD BCOR_MOUSE BCOR_MOUSE ELMEKFLTDYLNDLQGRSEDDTSGAWEFYGSSVCEP-DDESGYDVLANPPGPEDPDEEED Q3V2W5_MOUSE Q3V2W5_MOUSE ------------------------------------------------------------ MATCH CONSENSUS ??ME?FL??Y??DLQGR??DD????W?FYGS?VC??????SG?D?LANPPGP???????D

B3DKL5_DANRE B3DKL5_DANRE EQRDVFEFEFSDRPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSARTFRATFTHIEVVT Q6W2J8_DANRE Q6W2J8_DANRE EQRDVFEFEFSDRPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSARTFRATFTHIEVVT B0JZE5_XENTR B0JZE5_XENTR GYMDAFEFEFSDSPLLPCYNIQVSLSQGPRNWMLLSEVTKRLKMSSQTFTAENPHLEIVT BCOR_HUMAN BCOR_HUMAN AYSDVFEFEFSETPLLPCYNIQVSVAQGPRNWLLLSDVLKKLKMSSRIFRCNFPNVEIVT BCOR_MOUSE BCOR_MOUSE TYSDLFEFEFAESSLLPCYNIQVSVAQGPRNWLLLSDVLKKLKMSSRIFRSNFPNLEIVT Q3V2W5_MOUSE Q3V2W5_MOUSE ------------------------------------------------------------ MATCH CONSENSUS ???D?FEFEF????LLPCYNIQVS??QGPRNW?LLS?V?K?LKMS???F???????E?VT

B3DKL5_DANRE B3DKL5_DANRE IAEAEFYKQASLSQLFSCPEELEGFMPDSKELLDLVEISGELVALLGSSIECLDDRWEPA Q6W2J8_DANRE Q6W2J8_DANRE IAEAEFYKQASLSQLFSCPEELEGFMPDSKELLDLVEISGELVALLGSSIECLDDRWEPA B0JZE5_XENTR B0JZE5_XENTR ITEAEFYKQVSLSQLFSSPEGLEGFSPDSREMVELVEFTNELQTLLGSSIEWIDPENETT BCOR_HUMAN BCOR_HUMAN IAEAEFYRQVSASLLFSCSKDLEAFNPESKELLDLVEFTNEIQTLLGSSVEWLHPS-DLA BCOR_MOUSE BCOR_MOUSE IAEAEFYRQVSTSLLFSCPKDLEAFNPESKELLDLVEFTNELQTLLGSSVEWLHPS-DTG Q3V2W5_MOUSE Q3V2W5_MOUSE ------------------------------------------------------------ MATCH CONSENSUS I?EAEFY?Q?S?S?LFS????LE?F?P?S?E???LVE???E???LLGSS?E?????????

B3DKL5_DANRE B3DKL5_DANRE SRPRS Q6W2J8_DANRE Q6W2J8_DANRE SRPRS B0JZE5_XENTR B0JZE5_XENTR YSSC- BCOR_HUMAN BCOR_HUMAN SDNYW BCOR_MOUSE BCOR_MOUSE HENYW Q3V2W5_MOUSE Q3V2W5_MOUSE ----- MATCH CONSENSUS ?????


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