Alignment of the gene Family HBG050863 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
B1AU62_MOUSE B1AU62_MOUSE KIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSE------------- CDKL5_MOUSE CDKL5_MOUSE KIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSE------------- CDKL5_HUMAN CDKL5_HUMAN KIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSE------------- Q4SHR5_TETNG Q4SHR5_TETNG --PPLCDVMNKFEVLGIVGEGAYGVVLKCRHKETNELVAIKKFKDSEGEWRNEEGKRRWS Q4SV86_TETNG Q4SV86_TETNG -MANIA-------------------------RETNEIVAIKKFKDSE------------- B3DI12_DANRE B3DI12_DANRE KIPDIGNVMNKFEVLGIVGEGAYGVVLKCRHKETKELVAIKKFKDSE------------- MATCH . : :**:*:********** CONSENSUS ??P?I??VMNKFE?LG?VGEGAYGVVLKCRHKET?E?VAIKKFKDSE?????????????

B1AU62_MOUSE B1AU62_MOUSE ----------------ENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYV CDKL5_MOUSE CDKL5_MOUSE ----------------ENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYV CDKL5_HUMAN CDKL5_HUMAN ----------------ENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYV Q4SHR5_TETNG Q4SHR5_TETNG DRKKGGDNSIIPVSFTENEEVKETTLRELKMLRTLKQDNIVELKEAFRRRGKLYLVFEYV Q4SV86_TETNG Q4SV86_TETNG ----------------ENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYV B3DI12_DANRE B3DI12_DANRE ----------------ENEEVKETTLRELKMLRTLKQDNIVELKEAFRRRGKLYLVFEYV MATCH *********************:********************** CONSENSUS ????????????????ENEEVKETTLRELKMLRTLKQ?NIVELKEAFRRRGKLYLVFEYV

B1AU62_MOUSE B1AU62_MOUSE EKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLC CDKL5_MOUSE CDKL5_MOUSE EKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLC CDKL5_HUMAN CDKL5_HUMAN EKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLC Q4SHR5_TETNG Q4SHR5_TETNG ERNMLELLEEHPTGAPPDKVRSYIYQLIKAINWCHKNEIVHRDIKPENLLISSDDILKLC Q4SV86_TETNG Q4SV86_TETNG EKNMLELLEELPNGVPTDKARSYIYQLIRAIHWCHKHDIVHRDIKPENLLISSDDVLKLC B3DI12_DANRE B3DI12_DANRE EKNMLELLEELPNGALPDKVRSYIFQLIKAIHWCHKNEIVHRDIKPENLLISANDILKLC MATCH *:******** *.*. .:*.:***:***:**:****::************** :*:**** CONSENSUS EKNMLELLEE?PNG?PP?KV?SYIYQLIKAIHWCHKN?IVHRDIKPENLLIS??D?LKLC

B1AU62_MOUSE B1AU62_MOUSE DFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFP CDKL5_MOUSE CDKL5_MOUSE DFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFP CDKL5_HUMAN CDKL5_HUMAN DFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFP Q4SHR5_TETNG Q4SHR5_TETNG DFGFARNLSEGTDANYTEYVATRWYRSPELLLGAPYGKAVDMWSVGCILGELSDGQPLFP Q4SV86_TETNG Q4SV86_TETNG DFGFARSLSEGTDANYTEYVATRWYRSPELLLGAPYGKAVDMWSVGCILGELSDGQPLFP B3DI12_DANRE B3DI12_DANRE DFGFARNLSEGSDANYTEYVATRWYRSPELLLGAPYGKAVDMWSVGCILGELSDGQPLFP MATCH ******.****.:*************************:********************* CONSENSUS DFGFARNLSEG??ANYTEYVATRWYRSPELLLGAPYGK?VDMWSVGCILGELSDGQPLFP

B1AU62_MOUSE B1AU62_MOUSE GESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLD CDKL5_MOUSE CDKL5_MOUSE GESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLD CDKL5_HUMAN CDKL5_HUMAN GESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLD Q4SHR5_TETNG Q4SHR5_TETNG GESEIDQLFTIQKVLGPLPAEQMKLFYNNPRFHGIRFPSVTHPQTLERRYQGILSGLMLD Q4SV86_TETNG Q4SV86_TETNG GESEIDQLFTIQKVLGPLPSEQMKLFYNNPRFHGLRFPAVNHHQTLERRYLGIIGGGLLD B3DI12_DANRE B3DI12_DANRE GESEIDQLFTIQKVLGPLPPEQMKLFYSNPRFAGLRFPSVSHPQTLDRRYLGIINGLMLD MATCH *******************.*******.**** *:***:*.* *:*:*** **:.. :** CONSENSUS GESEIDQLFTIQKVLGPLP?EQMKLFY?NPRFHGLRFP?V?HPQ?LERRYLGI?????LD

B1AU62_MOUSE B1AU62_MOUSE LMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDR---------SPSRSTKRKPYHVESSTL CDKL5_MOUSE CDKL5_MOUSE LMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDR---------SPSRSTKRKPYHVESSTL CDKL5_HUMAN CDKL5_HUMAN LMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDR---------SPSRSAKRKPYHVESSTL Q4SHR5_TETNG Q4SHR5_TETNG LMKNLLLLNPTERYLTEQSLNHPAFQPLRQAERERPPPPASPNPPRSSKRKTHHHGENTV Q4SV86_TETNG Q4SV86_TETNG LLKNLLLLTPTERFLTEQCLNHHAFQTLRLVERSGPP---TPTPVRSSKRKPHH-GDNTT B3DI12_DANRE B3DI12_DANRE LMKNLLCLNPTERFLTEQCLNHPVFQGLRGPEQPAVP---SPTPPRSSKRKPYH-GDNTI MATCH *:**** * *::*:****.*** .** * :: .* **:***.:* ..* CONSENSUS LMKNLL?L?P??R?LTEQCLNHP?FQ??R???R??????????P?RS?KRKP?H????T?

B1AU62_MOUSE B1AU62_MOUSE SNRNQSTKGAALQTHHRSNSKDIQNLSVGLPRAEEGLP-ANESFLNGN--LAGATLSP-M CDKL5_MOUSE CDKL5_MOUSE SNRNQSTKGAALQTHHRSNSKDIQNLSVGLPRAEEGLP-ANESFLNGN--LAGATLSP-M CDKL5_HUMAN CDKL5_HUMAN SNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLP-ANESFLNGN--LAGASLSP-L Q4SHR5_TETNG Q4SHR5_TETNG PTRSHSKSTS-----RRSNNKECSS----LPRHGDLHHLGSKSFINGN-KPLPSSLSPTL Q4SV86_TETNG Q4SV86_TETNG PSRSHGGKSS---GGHRSSSRECSS----LPRHEDLHP-NNDAFLNGS-MTAAINLSPTL B3DI12_DANRE B3DI12_DANRE PSRSHGSKSS---SHRRANSKDCSS----LPRHEDLHR-STDSFLNGTNMPTSSTLSPTL MATCH ..*.:. . : :*:..:: .. *** : ..:*:**. .*** : CONSENSUS ??R????K????????RSNSK????????LPR??????????SFLNG????????LSP??

B1AU62_MOUSE B1AU62_MOUSE HTKT-YQAST--QPGSSSKDLTNNNIPHLLSPKEAKSKTEFDFNIDTKPS---EGPGT-- CDKL5_MOUSE CDKL5_MOUSE HTKT-YQAST--QPGSSSKDLTNNNIPHLLSPKEAKSKTEFDFNIDTKPS---EGPGT-- CDKL5_HUMAN CDKL5_HUMAN HTKT-YQASS--QPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPS---EGPGT-- Q4SHR5_TETNG Q4SHR5_TETNG HAKSQYMSQTLNRSPSSSKDLANNNLPHLLSPKEVKGKTEFDFNLGPSPKLPDQGHMA-- Q4SV86_TETNG Q4SV86_TETNG HPKN-YQPQVYNHSTSCSMDLASSNLPHLLSPGESKSKCDFDLNLGSKVP---DGPGA-- B3DI12_DANRE B3DI12_DANRE HPKS-YQAQTLSRSASSNKDLANNNLPHLLSPKDAKGKTEFDFNLGPKVGVASVGMDTST MATCH *.*. * .. :. * . **:..*:****** : *.* :**:*:... * : CONSENSUS H?K??YQ????????S?SKDL?NNN?PHLLSPKE?K?KTEFDFN???K??????G?????

B1AU62_MOUSE B1AU62_MOUSE -KY---LKSSTRSQQN--------------RHS-FMESSQSKAGTLQPSEK--QSRHSY- CDKL5_MOUSE CDKL5_MOUSE -KY---LKSSTRSQQN--------------RHS-FMESSQSKAGTLQPSEK--QSRHSY- CDKL5_HUMAN CDKL5_HUMAN -KY---LKSNSRSQQN--------------RHS-FMESSQSKAGTLQPNEK--QSRHSY- Q4SHR5_TETNG Q4SHR5_TETNG -KYGHSKPSSSRSHQQPQQQPPQPQQQQAVRHT-FLE---NKNNTLQSGAEKPHGRHTHS Q4SV86_TETNG Q4SV86_TETNG -KY---LNSNFRSQQN--------------RHS-FVE---GKTNTLQSGDK--HSRHGY- B3DI12_DANRE B3DI12_DANRE GKY---LKSSKQG-----------------RHSSFLE---GKTSTLQSGDK--HSRHNY- MATCH ** *. :. **: *:* .* .***.. : :.** : CONSENSUS ?KY???L?S??RS?Q???????????????RHS?F?E????K??TLQ???K???SRH?Y?

B1AU62_MOUSE B1AU62_MOUSE -ID----TIPQ---SSRSPSYRTKAKSHGALSDSKSVSNLSEARAQITETN--------T CDKL5_MOUSE CDKL5_MOUSE -ID----TIPQ---SSRSPSYRTKAKSHGALSDSKSVSNLSEARAQITETN--------T CDKL5_HUMAN CDKL5_HUMAN -ID----TIPQ---SSRSPSYRTKAKSHGALSDSKSVSNLSEARAQIAEPS--------T Q4SHR5_TETNG Q4SHR5_TETNG MADSAHGSMSS--SSKSSASYLSLSKSHSALSDAKSVGNLSDGRLHPDDLNQNIAGVGPG Q4SV86_TETNG Q4SV86_TETNG -ME-AHSSMPS-----SKFAYLNLSKSYGTLSDAKSVGNLNDVHLYADEP---------T B3DI12_DANRE B3DI12_DANRE -MESSHGSMPSTSSSKSSSSFLSLSKSHGALNDAKSVSNLAETRLHLDDPM---AGSGSG MATCH : ::.. . :: . :**:.:*.*:***.** : : : CONSENSUS ?????????P????S??S?SY????KSHGALSD?KSV?NL???R????????????????

B1AU62_MOUSE B1AU62_MOUSE SRYFPSSCLDLNS-PTSPTP-----TRHTDT-RTLLSPSGRNN----RNEGTLDS--RRT CDKL5_MOUSE CDKL5_MOUSE SRYFPSSCLDLNS-PTSPTP-----TRHTDT-RTLLSPSGRNN----RNEGTLDS--RRT CDKL5_HUMAN CDKL5_HUMAN SRYFPSSCLDLNS-PTSPTP-----TRHSDT-RTLLSPSGRNN----RNEGTLDS--RRT Q4SHR5_TETNG Q4SHR5_TETNG ARFFPASCLDLNAPAGPPGPPGSPSARHSD--RSGHSPASRSSGNIRMESSTLDSSSRHK Q4SV86_TETNG Q4SV86_TETNG SRYFPSSCLDLTA-PSSPA------ARRMD--RLGLVASGRGSTRSDRESNTLDSSHRRS B3DI12_DANRE B3DI12_DANRE SRYFPSSCLDLNAAPGSPRG-----ERHAGTERQGHSPSGRGSNR--LEGGTLDS--RRS MATCH :*:**:*****.: . .* *: . * .:.*.. : .**** *:. CONSENSUS SRYFPSSCLDLN??P?SP????????RH?D??R???SPSGR??????????TLDS??RR?

B1AU62_MOUSE B1AU62_MOUSE TTRHSKTMEELKLPEHMDS-------SHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSM CDKL5_MOUSE CDKL5_MOUSE TTRHSKTMEELKLPEHMDS-------SHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSM CDKL5_HUMAN CDKL5_HUMAN TTRHSKTMEELKLPEHMDS-------SHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSM Q4SHR5_TETNG Q4SHR5_TETNG SRHKSLVPEEAGAPELLDPGGAAM--PSTHTLPSPHESYHYGLGYTSPFSSQQRPQRHSM Q4SV86_TETNG Q4SV86_TETNG SIRL-KASEEAKSPDGLDPGDSGMERSHAHSLSSPREPLAYSQGYTSPFSSQQRPHRHSM B3DI12_DANRE B3DI12_DANRE SGRK-KTPDEPKPTDTLDPSRAAG--GHAHNLPSPHESYPYGLGYTSPFSSQQRPHRHSM MATCH : : . :* .: :*. :*.*.:*:*. *. ************:**** CONSENSUS ??R??K??EE?K?P???D?????????H?H?L??PHES??YGLGYTSPFSSQQRPHRHSM

B1AU62_MOUSE B1AU62_MOUSE YVTRDKVRAKGLDGSLSI----GQGMAARANSLQLLSPQ--------------------- CDKL5_MOUSE CDKL5_MOUSE YVTRDKVRAKGLDGSLSI----GQGMAARANSLQLLSPQ--------------------- CDKL5_HUMAN CDKL5_HUMAN YVTRDKVRAKGLDGSLSI----GQGMAARANSLQLLSPQ--------------------- Q4SHR5_TETNG Q4SHR5_TETNG YVRRERHRPHGAEGGMTGLSAPGQAIPTRASSLQLLSPQ--------------------- Q4SV86_TETNG Q4SV86_TETNG YVRRDHQRTHGAEEGLAV----GQGLPTRAKSLQLLSPQ--------------------- B3DI12_DANRE B3DI12_DANRE YVRRERHRPHGQENNLVV----GQGVPTRASSLQLLSPQLQHRTLPRHNTSSSREELTPE MATCH ** *:: *.:* : .: **.:.:**.******** CONSENSUS YV?R???R??G????L??????GQG???RA?SLQLLSPQ?????????????????????

B1AU62_MOUSE B1AU62_MOUSE --PGEQLPPEMTVARPSVKESSREGASSFH--T-RQKSEGGVYHDPHSDDGTAPKENRHL CDKL5_MOUSE CDKL5_MOUSE --PGEQLPPEMTVARPSVKESSREGASSFH--T-RQKSEGGVYHDPHSDDGTAPKENRHL CDKL5_HUMAN CDKL5_HUMAN --PGEQLPPEMTVARSSVKETSREGTSSFH--T-RQKSEGGVYHDPHSDDGTAPKENRHL Q4SHR5_TETNG Q4SHR5_TETNG ------LQHRTTLTGHSVSSSREDCTEDLTRVSGEQPASAAMYHDPHGEDGASSKENRMI Q4SV86_TETNG Q4SV86_TETNG -------LQHRTLPRHSGGSSREEDMSRV-----------GLYHDQQAEDGGSSKENRNI B3DI12_DANRE B3DI12_DANRE LSRNDQSPKEKPHSRPLIKDSTRDNTATFH--TQRPKNEAGMYHDAHMEDGTSSKENRTI MATCH . . . .: .: . .:*** : :** :.**** : CONSENSUS ???????????T??R?S???S???????????????????G?YHD?H??DG???KENR??

B1AU62_MOUSE B1AU62_MOUSE YNDPVPRRVGSFYRVPSPRPDN-SFHENNVSTR--VSSL-PSDSSSGTNHSKRQPGFDPW CDKL5_MOUSE CDKL5_MOUSE YNDPVPRRVGSFYRVPSPRPDN-SFHENNVSTR--VSSL-PSDSSSGTNHSKRQPGFDPW CDKL5_HUMAN CDKL5_HUMAN YNDPVPRRVGSFYRVPSPRPDN-SFHENNVSTR--VSSL-PSESSSGTNHSKRQPAFDPW Q4SHR5_TETNG Q4SHR5_TETNG FTESMPRRVGSFYRVPSPRPDNSSFHDAVGQGRGQVGPVGPVDPVAMAGHSKRQPAFD-W Q4SV86_TETNG Q4SV86_TETNG YSESMPRRVGSFYRVPSPRPDN-SFHDSRGQSR--DSGL-SSDGSRLTNHSKRQPGFDPW B3DI12_DANRE B3DI12_DANRE YSDSMPRRVGSFYRVPSPRPDN-TFLETTGQSR--VQAV-AAENPTMTNHSKRQTNFDPW MATCH :.:.:***************** :* : . * : . : :.*****. ** * CONSENSUS Y????PRRVGSFYRVPSPRPDN?SFH??????R??V???????????TNHSKRQP?FDPW

B1AU62_MOUSE B1AU62_MOUSE KSPENI--SHADQLKEKEKQGFFRSMKKKKKKTQTVPNTDGPDLLTLQKAIHSSSTASSR CDKL5_MOUSE CDKL5_MOUSE KSPENI--SHADQLKEKEKQGFFRSMKKKKKKTQTVPNTDGPDLLTLQKAIHSSSTASSR CDKL5_HUMAN CDKL5_HUMAN KSPENI--SHSEQLKEKEKQGFFRSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSR Q4SHR5_TETNG Q4SHR5_TETNG TAAEAMVMNPPEPVKEKEKQGFFRAIKKKKKKTQI------------------------- Q4SV86_TETNG Q4SV86_TETNG TGPDTVVLNPSEPSKEKEKQGFFRAIKKKKKKSQMVT----------------------- B3DI12_DANRE B3DI12_DANRE NNSEAMVMNPPEVPKQKEKQGFFRAIKKKKKKSQPVPSETQQDQLVLQRPVKSSSHHSSR MATCH . .: : . .: *:********::******:* CONSENSUS ???E??????????KEKEKQGFFR??KKKKKK?Q?V????????????????????????

B1AU62_MOUSE B1AU62_MOUSE PKE--------------------------------WRPEKLSDLQTQSQPLKSLRKLLHL CDKL5_MOUSE CDKL5_MOUSE PKE--------------------------------WRPEKLSDLQTQSQPLKSLRKLLHL CDKL5_HUMAN CDKL5_HUMAN PKE--------------------------------WRPEKISDLQTQSQPLKSLRKLLHL Q4SHR5_TETNG Q4SHR5_TETNG -----------------------------------------------SQPLKSLRRLLHL Q4SV86_TETNG Q4SV86_TETNG ------------------------------------------------------------ B3DI12_DANRE B3DI12_DANRE HRNRDRERERDMERDRERERDRNRDRDRERDRDNTWPPEKQPEVQPQNQPLKSLRKLLHL MATCH CONSENSUS ????????????????????????????????????????????????QPLKSLR?LLHL

B1AU62_MOUSE B1AU62_MOUSE SSST-----NHPASSDP----RFQ-PLTA---QQAKNSFSEIRIHPLSQATGGSSNIRQE CDKL5_MOUSE CDKL5_MOUSE SSST-----NHPASSDP----RFQ-PLTA---QQAKNSFSEIRIHPLSQATGGSSNIRQE CDKL5_HUMAN CDKL5_HUMAN SSAS-----NHPASSDP----RFQ-PLTA---QQTKNSFSEIRIHPLSQASGGSSNIRQE Q4SHR5_TETNG Q4SHR5_TETNG SPSSSNQGQQSPAPPAPPPDLRFQAPLPNPPQPPSKAGYPEARGHADSRAHSGVSSSSQA Q4SV86_TETNG Q4SV86_TETNG ------------------------------------------------------------ B3DI12_DANRE B3DI12_DANRE SSPATS---NQPPPPDRSAELRFQ-PLPN---PPSKANLNEVRGHP----AGSVTPNTKS MATCH CONSENSUS S??????????P?????????RFQ?PL????????K????E?R?H???????????????

B1AU62_MOUSE B1AU62_MOUSE PTPK-GRPALQLP-----GSSLLRYNGWKHSRS--------------------------- CDKL5_MOUSE CDKL5_MOUSE PTPK-GRPALQLP-----GSSLLRYNGWKHSRS--------------------------- CDKL5_HUMAN CDKL5_HUMAN PAPK-GRPALQLPDGGCDGRRQRHHSGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPN Q4SHR5_TETNG Q4SHR5_TETNG KSRKASYPIPGQIESSWHVSALQRAEGAQFTPEQLGIQ---------------------- Q4SV86_TETNG Q4SV86_TETNG ------------------------------------------------------------ B3DI12_DANRE B3DI12_DANRE RKPH-NYPLPGQIESSWHVSALNRAEGAPYPDQLANKGGQNGIGF--------------- MATCH CONSENSUS ???????P??????????????????G?????????????????????????????????

B1AU62_MOUSE B1AU62_MOUSE ---------------------------------------------------------RSS CDKL5_MOUSE CDKL5_MOUSE ---------------------------------------------------------RSS CDKL5_HUMAN CDKL5_HUMAN RALHRPISSPAPYPVLQVRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRA Q4SHR5_TETNG Q4SHR5_TETNG ---------------------------------------------------------TRA Q4SV86_TETNG Q4SV86_TETNG ------------------------------------------------------------ B3DI12_DANRE B3DI12_DANRE ---------------------------------------------------------TRA MATCH CONSENSUS ????????????????????????????????????????????????????????????

B1AU62_MOUSE B1AU62_MOUSE QPDEVIFLASHEKWKQ--- CDKL5_MOUSE CDKL5_MOUSE QPDEVIFLASHEKWKQ--- CDKL5_HUMAN CDKL5_HUMAN QVNQAALLTYHENAALTGK Q4SHR5_TETNG Q4SHR5_TETNG ERTHLYPSIPHQDPKPQ-- Q4SV86_TETNG Q4SV86_TETNG ------------------- B3DI12_DANRE B3DI12_DANRE ARTRMPNLNDLKETAL--- MATCH CONSENSUS ???????????????????


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