Alignment of the gene Family HBG050957 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
F120A_XENTR F120A_XENTR GVQGFQEYMEKHCPSAVVPVELQKLAR--------------------------------- B2KI98_RHIFE B2KI98_RHIFE GVQGFQDYIEKHCPSAVVPVELQKLAR--------------------------------- F120A_BOVIN F120A_BOVIN GVQGFQDYIEKHCPSAVVPVELQKLAR--------------------------------- F120A_MOUSE F120A_MOUSE GVQGFQDYIEKHCPSAVVPVELQKLAR--------------------------------- F120A_HUMAN F120A_HUMAN GVQGFQDYIEKHCPSAVVPVELQKLAR--------------------------------- Q4S6D5_TETNG Q4S6D5_TETNG GVQGFQEYLEKRCPRGGGPGG---------------------PPEARPDRGPP------A B1AQ10_HUMAN B1AQ10_HUMAN ------------------------------------------------------------ F120C_HUMAN F120C_HUMAN GVQGFQEFLEKRCPGAVVPVDLLKLARTVSRQQQQQHLHRQLPPTAALAPGAPRAARGSV B7ZW94_MOUSE B7ZW94_MOUSE GVQGFQEFLEKRCPGAVVPVDLLKLARTVSRQQQQQHLHRQLPP-AALAPGAPRITRGSA Q3V3X9_MOUSE Q3V3X9_MOUSE GVQGFQEFLEKRCPGAVVPVDLLKLARTVSRQQQQQHLHRQLPP-AALAPGAPRITRGSA F120C_MOUSE F120C_MOUSE GVQGFQEFLEKRCPGAVVPVDLLKLARTVSRQQQQQHLHRQLPP-AALAPGAPRITRGSA Q3U0F6_MOUSE Q3U0F6_MOUSE GVQGFQEFLEKRCPGAVVPVDLLKLARTVSRQQQQQHLHRQLPP-AALAPGAPRITRGSA MATCH CONSENSUS GVQGFQ???EK?CP?AVVPV?L?KLAR?????????????????????????????????

F120A_XENTR F120A_XENTR ------------GSLVGGGRQRPPQSPL----------------------------RLLV B2KI98_RHIFE B2KI98_RHIFE ------------GSLVGGGRQRPPHTPL----------------------------RLLV F120A_BOVIN F120A_BOVIN ------------GSLVGGGRQRPPHTPL----------------------------RLLV F120A_MOUSE F120A_MOUSE ------------GSLVGGGRQRPPQTPL----------------------------RLLV F120A_HUMAN F120A_HUMAN ------------GSLVGGGRQRPPQTPL----------------------------RLLV Q4S6D5_TETNG Q4S6D5_TETNG SSPPSPTPPTS---------PRAHASPAP--AHTDPDRRGFQ----PP------------ B1AQ10_HUMAN B1AQ10_HUMAN ------------------------------------------------------------ F120C_HUMAN F120C_HUMAN PLQP-PLPPAALGAYSGGAGPTRHHHPAHHFHHHGQAQPGLHPPLPPPPPPQLPGARVLV B7ZW94_MOUSE B7ZW94_MOUSE PLPPPPLPPAAFGVYSGGAGPSRHHHPAHHFHHHGQAPPGLH----PPPPPPLPGARVLV Q3V3X9_MOUSE Q3V3X9_MOUSE PLPPPPLPPAAFGAYSGGAGPSRHHHPAHHFHHHGQAPPGLH----PPPPPPLPGARVLV F120C_MOUSE F120C_MOUSE PLPPPPLPPAAFGAYSGGAGPSRHHHPAHHFHHHGQAPPGLH----PPPPPPLPGARVLV Q3U0F6_MOUSE Q3U0F6_MOUSE PLPPPPLPPAAFGAYSGGAGPSRHHHPAHHFHHHGQAPPGLH----PPPPPPLPGARVLV MATCH CONSENSUS ????????????G???GG????????P?????????????????????????????R?LV

F120A_XENTR F120A_XENTR DAENCLHRLYGGFYTDWVSGG--QWNHMLGYLGALAKACY---AGNIQLFVFFNGALEKG B2KI98_RHIFE B2KI98_RHIFE DADNCLHRLYGGFYTDWVSGG--QWNHMLGYLAALAKACF---GGNIELFVFFNGALEKA F120A_BOVIN F120A_BOVIN DADNCLHRLYGGFYTDWVSGG--QWNHMLGYLAALAKACF---GGNIELFVFFNGALEKA F120A_MOUSE F120A_MOUSE DADNCLHRLYGGFYTDWVSGG--QWNHMLGYLAALAKACF---GGNIELFVFFNGALEKA F120A_HUMAN F120A_HUMAN DADNCLHRLYGGFYTDWVSGG--QWNHMLGYLAALAKACF---GGNIELFVFFNGALEKA Q4S6D5_TETNG Q4S6D5_TETNG ---AALRRLPDGLG---VRGGVERHARLPGRPVAGVPVPGRPGAGG-----GFQRHPGQG B1AQ10_HUMAN B1AQ10_HUMAN ---------------------------MLGYLSALCQACAYPGGDGLELVVMFPGGLGKD F120C_HUMAN F120C_HUMAN DAGSALPRLYGGYQTDWVCGG--QWNAMLGYLSALCQACAYPGGDGLELVVMFPGGLGKD B7ZW94_MOUSE B7ZW94_MOUSE DAGSALPRLYGGYQTDWVCGG--QWNAMLGYLSALCQACAYPGGDGLELVVMFPGGLGKD Q3V3X9_MOUSE Q3V3X9_MOUSE DAGSALPRLYGGYQTDWVCGG--QWNAMLGYLSALCQACAYPGGDGLELVVMFPGGLGKD F120C_MOUSE F120C_MOUSE DAGSALPRLYGGYQTDWVCGG--QWNAMLGYLSALCQACAYPGGDGLELVVMFPGGLGKD Q3U0F6_MOUSE Q3U0F6_MOUSE DAGSALPRLYGGYQTDWVCGG--QWNAMLGYLSALCQACAYPGGDGLELVVMFPGGLGKD MATCH : * * . ... * : CONSENSUS DA???L?RLYGG??TDWV?GG??QWN?MLGYL?AL??AC????G???EL?V?F?G?L?K?

F120A_XENTR F120A_XENTR RLHEWVKRQGNERQTAQQIVSHIQNKGTPPPKVWFLPPICMAHCIRLALLRFHIKVAQSI B2KI98_RHIFE B2KI98_RHIFE RLHEWVKRQGNERQTAQQIVSHVQNKGTPPPKVWFLPPVCMAHCIRLALIRFHVKVAQSI F120A_BOVIN F120A_BOVIN RLHEWVKRQGNERQTAQQIVSHVQNKGTPPPKVWFLPPVCMAHCIRLALIRFHVKVAQSI F120A_MOUSE F120A_MOUSE RLHEWVKRQGNERQTAQQIVSHVQNKGTPPPKVWFLPPVCMAHCIRLALIRFHVKVAQSI F120A_HUMAN F120A_HUMAN RLHEWVKRQGNERQTAQQIVSHVQNKGTPPPKVWFLPPVCMAHCIRLALIRFHVKVAQSI Q4S6D5_TETNG Q4S6D5_TETNG ALARVGAACTEPATDGAVIVNHVGSKATPPPRAWFLPPACLSHCVRLAMFRFRVRVVQTL B1AQ10_HUMAN B1AQ10_HUMAN RLAEWGRRCQAERQTAQLIVGHVGNKGTPPPRAWFLPPACLSHCVRLALIRFRVKVFQSL F120C_HUMAN F120C_HUMAN RLAEWGRRCQAERQTAQLIVGHVGNKGTPPPRAWFLPPACLSHCVRLALIRFRVKVFQSL B7ZW94_MOUSE B7ZW94_MOUSE RLAEWGRRCQAERQTAQLIVGHVGNKGTPPPRAWFLPPACLSHCVRLALIRFRVKVFQSL Q3V3X9_MOUSE Q3V3X9_MOUSE RLAEWGRRCQAERKTAQLIVGHVGNKGTPPPRAWFLPPACLSHCVRLALIRFRVKVFQSL F120C_MOUSE F120C_MOUSE RLAEWGRRCQAERQTAQLIVGHVGNKGTPPPRAWFLPPACLSHCVRLALIRFRVKVFQSL Q3U0F6_MOUSE Q3U0F6_MOUSE RLAEWGRRCQAERQTAQLIVGHVGNKGTPPPRAWFLPPACLSHCVRLALIRFRVKVFQSL MATCH * . . **.*: .*.****:.***** *::**:***::**:::* *:: CONSENSUS RL?EW??R???ERQTAQ?IV?HV?NKGTPPP??WFLPP?C??HC?RLALIRF?VKV?QS?

F120A_XENTR F120A_XENTR EDHHQEVITFCRENGFHGLVAYDSDYALCNIPYYFSAHALKLSRNGKSLTTSQYLMHEVA B2KI98_RHIFE B2KI98_RHIFE EDHHQEVIGFCRENGFHGLVAYDSDYALCNIPYYFSAHALKLSRNGKSLTTSQYLMHEVA F120A_BOVIN F120A_BOVIN EDHHQEVIGFCRENGFHGLVAYDSDYALCNIPYYFSAHALKLSRNGKSLTTSQYLMHEVA F120A_MOUSE F120A_MOUSE EDHHQEVIGFCRENGFHGLVAYDSDYALCNIPYYFSAHALKLSRNGKSLTTSQYLMHEVA F120A_HUMAN F120A_HUMAN EDHHQEVIGFCRENGFHGLVAYDSDYALCNIPYYFSAHALKLSRNGKSLTTSQYLMHEVA Q4S6D5_TETNG Q4S6D5_TETNG EDHHQEVLSLYRDFGFAGLIAQDSEFALCNVPAYFSSHALKLSWNGKNLTTHQYLLSEAA B1AQ10_HUMAN B1AQ10_HUMAN EDHHLEVVAFFRENGFHGLLAHDSEYALYNIPSYYSSHALKLSWNGKNLTTNQFLMQEVA F120C_HUMAN F120C_HUMAN EDHHLEVVAFFRENGFHGLLAHDSEYALYNIPSYYSSHALKLSWNGKNLTTNQFLMQEVA B7ZW94_MOUSE B7ZW94_MOUSE EDHHLEVVAFFRENGFHGLLAHDSEYALYNIPSYYSSHALKLSWNGKNLTTNQFLMQEVA Q3V3X9_MOUSE Q3V3X9_MOUSE EDHHLEVVAFFRENGFHGLLAHDSEYALYNIPSYYSSHALKLSWNGKNLTTNQFLMQEVA F120C_MOUSE F120C_MOUSE EDHHLEVVAFFRENGFHGLLAHDSEYALYNIPSYYSSHALKLSWNGKNLTTNQFLMQEVA Q3U0F6_MOUSE Q3U0F6_MOUSE EDHHLEVVAFFRENGFHGLLAHDSEYALYNIPSYYSSHALKLSWNGKNLTTNQFLMQEVA MATCH **** **: : *: ** **:* **::** *:* *:*:****** ***.*** *:*: *.* CONSENSUS EDHH?EV??F?RENGFHGL?A?DS?YAL?NIP?Y?S?HALKLS?NGK?LTT?Q?LM?EVA

F120A_XENTR F120A_XENTR KQLDLNPNRFPIFAALLGNHILPDEDLAAFHWSLLGPEHPLASLKVRAHQLVLPPCDVVI B2KI98_RHIFE B2KI98_RHIFE KQLDLNPNRFPIFAALLGNHILPDEDLASFHWSLLGPEHPLASLKVRAHQLVLPPCDVVI F120A_BOVIN F120A_BOVIN KQLDLNPNRFPIFAALLGNHILPDEDLASFHWSLLGPEHPLASLKVRAHQLVLPPCDVVI F120A_MOUSE F120A_MOUSE KQLDLNPNRFPIFAALLGNHILPDEDLASFHWSLLGPEHPLASLKVRAHQLVLPPCDVVI F120A_HUMAN F120A_HUMAN KQLDLNPNRFPIFAALLGNHILPDEDLASFHWSLLGPEHPLASLKVRAHQLVLPPCDVVI Q4S6D5_TETNG Q4S6D5_TETNG RQLGLKTQHLPCFAALLGNHILPDEDLAAFHWSLLGPEHPLASLKVRAHQLVLPPCEVVI B1AQ10_HUMAN B1AQ10_HUMAN KQLGLKRMNFPIFAALLGNHILPDEDLAAFHWSLLGPEHPLASLKVRAHQLVLPPCDVVI F120C_HUMAN F120C_HUMAN KQLGLKRMNFPIFAALLGNHILPDEDLAAFHWSLLGPEHPLASLKVRAHQLVLPPCDVVI B7ZW94_MOUSE B7ZW94_MOUSE KQLGLKRMNFPIFAALLGNHILPDEDLAAFHWSLLGPEHPLASLKVRAHQLVLPPCDVVI Q3V3X9_MOUSE Q3V3X9_MOUSE KQLGLKRMNFPIFAALLGNHILPDEDLAAFHWSLLGPEHPLASLKVRAHQLVLPPCDVVI F120C_MOUSE F120C_MOUSE KQLGLKRMNFPIFAALLGNHILPDEDLAAFHWSLLGPEHPLASLKVRAHQLVLPPCDVVI Q3U0F6_MOUSE Q3U0F6_MOUSE KQLGLKRMNFPIFAALLGNHILPDEDLAAFHWSLLGPEHPLASLKVRAHQLVLPPCDVVI MATCH :**.*: .:* ****************:***************************:*** CONSENSUS KQL?L????FPIFAALLGNHILPDEDLA?FHWSLLGPEHPLASLKVRAHQLVLPPCDVVI

F120A_XENTR F120A_XENTR KAVADYVRNIQDTNDLDAIAKDVFQHSQSRTDDKVSRFKKAIAYYRATNKPLSCP-PAHY B2KI98_RHIFE B2KI98_RHIFE KAVADYVRNIQDTSDLDAIAKDVFQHSQSRTDDKVIRFKRAIGYYSATSKPVAFH-PPHY F120A_BOVIN F120A_BOVIN KAVADYVRNIQDTSDLDAIAKDVFQHSQSRTDDKVIRFKRAIGYYSATSKPMAFH-PPHY F120A_MOUSE F120A_MOUSE KAVADYVRNIHDTSDLDAIAKDVFQHSQSRTDDKVIRFKRAVGYYSATSKPMPFH-PPHY F120A_HUMAN F120A_HUMAN KAVADYVRNIQDTSDLDAIAKDVFQHSQSRTDDKVIRFKRAIGYYSATSKPMSFH-PPHY Q4S6D5_TETNG Q4S6D5_TETNG KAVSEYVSSIKDLGNLDAIARDVFKQSQSRMEDKVERFKKAVEYFSAACKPRSPNMGPSS B1AQ10_HUMAN B1AQ10_HUMAN KAVSEYVSSIKDPSNLDVVGKDVFKQSQSRTEDKIERFKKAVEYYSVTTKLSSLPVGPSF F120C_HUMAN F120C_HUMAN KAVSEYVSSIKDPSNLDVVGKDVFKQSQSRTEDKIERFKKAVEYYSVTTKLSSLPVGPSF B7ZW94_MOUSE B7ZW94_MOUSE KAVSEYVSSIKDPSNLDVVGKDVFKQSQSRTEDKIERFKKAVEYYSVTTKLSSLPVGPSF Q3V3X9_MOUSE Q3V3X9_MOUSE KAVSEYVSSIKDPSNLDVVGKDVFKQSQSRTEDKIERFKKAVEYYSVTTKLSSLPVGPSF F120C_MOUSE F120C_MOUSE KAVSEYVSSIKDPSNLDVVGKDVFKQSQSRTEDKIERFKKAVEYYSVTTKLSSLPVGPSF Q3U0F6_MOUSE Q3U0F6_MOUSE KAVSEYVSSIKDPSNLDVVGKDVFKQSQSRTEDKIERFKKAVEYYSVTTKLSSLPVGPSF MATCH ***::** .*:* .:**.:.:***::**** :**: ***:*: *: .: * . . CONSENSUS KAV??YV??I?D?S?LD???KDVF??SQSRT?DK??RFK?A??YYS?T?K???????P??

F120A_XENTR F120A_XENTR L---G-RPNPGGIHSMVPPYPSPQMLNIPQGSVQSRPM---------------------- B2KI98_RHIFE B2KI98_RHIFE L----ARPNPFGMPGIVPPYAPPQMLNIPQTSLQAKPMAPQGPSP-GTPGQGPHPYSLAE F120A_BOVIN F120A_BOVIN L----ARPNPFGMPGIVPPYVPPQMLNIPQTSLQAKPVAPQVPSP-GAPGQGPHPYNLAE F120A_MOUSE F120A_MOUSE L----ARPNPFGMPGMVPPYVPPQMLNIPQTSLQAKPAVPQVPSPGGTPGQAPYPYSLSE F120A_HUMAN F120A_HUMAN L---AARPGPFGMPGMVPPHVPPQMLNIPQTSLQAKPVAPQVPSPGGAPGQGPYPYSLSE Q4S6D5_TETNG Q4S6D5_TETNG FILPGFGPNLFGGP----P---GHMGPMQPG----KN---------------------QV B1AQ10_HUMAN B1AQ10_HUMAN L---GFRNNRLGNP----PLPRNQVGTISAG----KPMFSH-----QVPQKVKYPPPFPV F120C_HUMAN F120C_HUMAN L---GFRNNRLGNP----PLPRNQVGTISAG----KPMFSH-----QVPQKVKYPPPFPV B7ZW94_MOUSE B7ZW94_MOUSE L---GFRNNRLGNP----PLPRNQMGPISPG----KPMFSR-----QVPQKMKYPPPFPM Q3V3X9_MOUSE Q3V3X9_MOUSE L---GFRNNRLGNP----PLPRNQMGPISPG----KPMFSR-----QVPQKMKYPPPFPM F120C_MOUSE F120C_MOUSE L---GFRNNRLGNP----PLPRNQMGPISPG----KPMFSR-----QVPQKMKYPPPFPM Q3U0F6_MOUSE Q3U0F6_MOUSE L---GFRNNRLGNP----PLPRNQMGPISPG----KPMFSR-----QVPQKMKYPPPFPM MATCH : . * * :: : : CONSENSUS L?????R?N??G?P????P????QM??I???????KP???????????P?????P?????

F120A_XENTR F120A_XENTR -------TGGKCVSEQNNYSNIPHEGKHTPLYERSSPINPAQSGSPNHVDSNYFPP---- B2KI98_RHIFE B2KI98_RHIFE -PALTLETSGKNLTEQNNYSNIPHEGKHTPLYERSSPINPAPSGSPNHVDSAYFPG---- F120A_BOVIN F120A_BOVIN -PALTLETSGKNLTEQN-YSNIPHEGKHTPLYERSSPINPAPSGSPNHVDSAYFPG---- F120A_MOUSE F120A_MOUSE -PALTLDTSGKNLTEQNSYSNIPHEGKHTPLYERSSPINLAQSGSPNHVDSAYFPG---- F120A_HUMAN F120A_HUMAN PAPLTLDTSGKNLTEQNSYSNIPHEGKHTPLYERSSPINPAQSGSPNHVDSAYFPG---- Q4S6D5_TETNG Q4S6D5_TETNG SPGS--------------FSEDLH------------------------------------ B1AQ10_HUMAN B1AQ10_HUMAN GPNSSLLFSSHALGESHAFSEDPML-QNSPFANWAVSYDSSASQFPNYLPSKASPPLGPD F120C_HUMAN F120C_HUMAN GPNSSLLFSSHALGESHAFSEDPML-QNSPFANWAVSYDSSASQFPNYLPSKASPPLGPD B7ZW94_MOUSE B7ZW94_MOUSE GPNSSLLFS-HSVGESHAFSEDAML-QDNSFANWAVSYDSNTSQFPNCLTSKTSPPLGPD Q3V3X9_MOUSE Q3V3X9_MOUSE GPNSSLLFS-HSVGESHAFSEDAML-QDNSFANWAVSYDSNTSQFPNCLTSKTSPPLGPD F120C_MOUSE F120C_MOUSE GPNSSLLFS-HSVGESHAFSEDAML-QDNSFANWAVSYDSNTSQFPNCLTSKTSPPLGPD Q3U0F6_MOUSE Q3U0F6_MOUSE GPNSSLLFS-HSVGESHAFSEDAML-QDNSFANWAVSYDSNTSQFPNCLTSKTSPPLGPD MATCH :*: CONSENSUS ?P???L??S?????E????S??????????????????????S??PN???S???P?????

F120A_XENTR F120A_XENTR SSASSSSENEDGNGGSANHVSG---NKPTWDK-GKKSEKANKKDSTEQAKA-EVPSPSGS B2KI98_RHIFE B2KI98_RHIFE SSTSSSSDNDEGSGGAANHISG---NKIGWEKTGSHSEPQARGDPGDQTKAEGSSTASSG F120A_BOVIN F120A_BOVIN SSTSSSSDNDEGSGGAANHISG---NKIGWEKTGSHSEPQARGDPGDQTKAEGSSTASSG F120A_MOUSE F120A_MOUSE SSTSSSSDNDEGGGGATNHISG---NKIGWEKTGSHAEPLARGDPGDQVKVEGSSTASSG F120A_HUMAN F120A_HUMAN SSTSSSSDNDEGSGGATNHISG---NKIGWEKTGSHSEPQARGDPGDQTKAEGSSTASSG Q4S6D5_TETNG Q4S6D5_TETNG --------GDEPNDSNSNHLTDKSSR---WED------P--AGRTGS---A------SGD B1AQ10_HUMAN B1AQ10_HUMAN SSHSSSSDGDEPNGASSDHITEAFHHQPEWGN------P--NRDRGS---W-AQPVDTGV F120C_HUMAN F120C_HUMAN SSHSSSSDGDEPNGASSDHITEAFHHQPEWGN------P--NRDRGS---W-AQPVDTGV B7ZW94_MOUSE B7ZW94_MOUSE SSHSSSSDGDEANGAGSEQITEAVQQQPGWED------P--NGDRGA---W-GQPADAGV Q3V3X9_MOUSE Q3V3X9_MOUSE SSHSSSSDGDEANGAGSEQITEAVQQQPGWED------P--NGDRGA---W-GQPADAGV F120C_MOUSE F120C_MOUSE SSHSSSSDGDEANGAGSEQITEAVQQQPGWED------P--NGDRGA---W-GQPADAGV Q3U0F6_MOUSE Q3U0F6_MOUSE SSHSSSSDGDEANGAGSEQITEAVQQQPGWED------P--NGDRGA---W-GQPADAGV MATCH .:: ... ::::: . * . :. CONSENSUS SS?SSSSD?DE??G?????I?????????W????????P????D?G??????????????

F120A_XENTR F120A_XENTR GNKGTDKKANQPGHMQIPCLLSMPTRNHMDITTPPLPQVA-------------------- B2KI98_RHIFE B2KI98_RHIFE SQLAEGKGSQIGTVQPIPCLLSMPTRNHMDITTPPLPPVA-------------------- F120A_BOVIN F120A_BOVIN SQLAEGKGNQIGTVQPIPCLLSMPTRNHMDITTPPLPPVA-------------------- F120A_MOUSE F120A_MOUSE SQLAEGKGSHMGTVQPIPCLLSMPTRNHMDITTPPLPPVA-------------------- F120A_HUMAN F120A_HUMAN SQLAEGKGSQMGTVQPIPCLLSMPTRNHMDITTPPLPPVA-------------------- Q4S6D5_TETNG Q4S6D5_TETNG GSQGNGSG-P-----NIPSLLSMATRSHMDITTPPLPQVNTRLEAFSAAGESAAQSHSLA B1AQ10_HUMAN B1AQ10_HUMAN SEASLGDGEP-----HIPSLLSMSTRNHMDITIPPLPPVA-------------------- F120C_HUMAN F120C_HUMAN SEASLGDGEP-----HIPSLLSMSTRNHMDITIPPLPPVA-------------------- B7ZW94_MOUSE B7ZW94_MOUSE SETTVAESEP-----HIPSLLSMSTRNHMDITIPPLPPVA-------------------- Q3V3X9_MOUSE Q3V3X9_MOUSE SETTVAESEP-----HIPSLLSMSTRNHMDITIPPLPPVA-------------------- F120C_MOUSE F120C_MOUSE SETTVAESEP-----HIPSLLSMSTRNHMDITIPPLPPVA-------------------- Q3U0F6_MOUSE Q3U0F6_MOUSE SETTVAESEP-----HIPSLLSMSTRNHMDITIPPLPPVA-------------------- MATCH .. . **.****.**.***** **** * CONSENSUS S???????????????IP?LLSM?TRNHMDIT?PPLPPVA????????????????????

F120A_XENTR F120A_XENTR -----PEVLRVAEHRHKKGLMYPYIFHVLTKGEMKIPVTIEDEINKDLPPAAILYRPVRQ B2KI98_RHIFE B2KI98_RHIFE -----PEVLRVAEHRHKKGLMYPYIFHVLTKGEIKIAVSIEDEASKDLPPAALLYRPVRQ F120A_BOVIN F120A_BOVIN -----PEVLRVAEHRHKKGLMYPYIFHVLTKGEIKIAVSIEDEASKDLPPAALLYRPVRQ F120A_MOUSE F120A_MOUSE -----PEVLRVAEHRHKKGLMYPYIFHILTKGEIKIAVSIEDEANKDLPPAALLYRPVRQ F120A_HUMAN F120A_HUMAN -----PEVLRVAEHRHKKGLMYPYIFHVLTKGEIKIAVSIEDEANKDLPPAALLYRPVRQ Q4S6D5_TETNG Q4S6D5_TETNG SLQVSAEVLRVAEHRHRRGLMYPQIYHILTKGEMKMPVCIEDECNSELPPASLLFRTARQ B1AQ10_HUMAN B1AQ10_HUMAN -----PEVLRVAEHRHRRGLMYPYIYHVLTKGEIKIPVCIEDECNMELPPAALLFRSARQ F120C_HUMAN F120C_HUMAN -----PEVLRVAEHRHRRGLMYPYIYHVLTKGEIKIPVCIEDECNMELPPAALLFRSARQ B7ZW94_MOUSE B7ZW94_MOUSE -----PEVLRVAEHRHRRGLMYPYIYHVLTKGEIKIPVCIEDECNMELPPAALLFRSARQ Q3V3X9_MOUSE Q3V3X9_MOUSE -----PEVLRVAEHRHRRGLMYPYIYHVLTKGEIKIPVCIEDECNMELPPAALLFRSARQ F120C_MOUSE F120C_MOUSE -----PEVLRVAEHRHRRGLMYPYIYHVLTKGEIKIPVCIEDECNMELPPAALLFRSARQ Q3U0F6_MOUSE Q3U0F6_MOUSE -----PEVLRVAEHRHRRGLMYPYIYHVLTKGEIKIPVCIEDECNMELPPAALLFRSARQ MATCH .**********::***** *:*:*****:*:.* **** . :****::*:*..** CONSENSUS ?????PEVLRVAEHRH??GLMYPYI?HVLTKGEIKI?V?IEDE?N??LPPAALL?R??RQ

F120A_XENTR F120A_XENTR YVYGVLFSLAESRKKAERLAFRKNRMPPEFYVPDYPVIIKEWAAYKGKSPQTPELVEALA B2KI98_RHIFE B2KI98_RHIFE YVYGVLFSLAESRKKTERLAFRKNRLPPEF----SPVIIKEWAAYKGKSPQTPELVEALA F120A_BOVIN F120A_BOVIN YVYGVLFSLAESRKKTERLAFRKNRLPPEF----SPVIIKEWAAYKGKSPQTPELVEALA F120A_MOUSE F120A_MOUSE YVYGVLFSLAESRKKTERLAFRKNRLPPEF----SPLIIKEWAAYKGKSPQTPELVEALA F120A_HUMAN F120A_HUMAN YVYGVLFSLAESRKKTERLAFRKNRLPPEF----SPVIIKEWAAYKGKSPQTPELVEALA Q4S6D5_TETNG Q4S6D5_TETNG YAYGVLFSLAETQRRLERLALRK-RAPLEV----PPVIVKEWCSSKAKSALTPELVPALC B1AQ10_HUMAN B1AQ10_HUMAN YVYGVLFSLAETQRKMERLAMRR-RLPVEV----PSVILKEWSAYKGKSPQTPELVSALT F120C_HUMAN F120C_HUMAN YVYGVLFSLAETQRKMERLAMRR-RLPVEV----PSVILKEWSAYKGKSPQTPELVSALT B7ZW94_MOUSE B7ZW94_MOUSE YVYGVLFSLAETQRKMERLAIRR-RLPMEV----PSVILKEWSAYKGKSPQTPELVSALT Q3V3X9_MOUSE Q3V3X9_MOUSE YVYGVLFSLAETQRKMERLAIRR-RLPMEV----PSVILKEWSAYKGKSPQTPELVSALT F120C_MOUSE F120C_MOUSE YVYGVLFSLAETQRKMERLAIRR-RLPMEV----PSVILKEWSAYKGKSPQTPELVSALT Q3U0F6_MOUSE Q3U0F6_MOUSE YVYGVLFSLAETQRKMERLAIRR-RLPMEV----PSVILKEWSAYKGKSPQTPELVSALT MATCH *.*********:::: ****:*: * * *. .:*:***.: *.**. ***** ** CONSENSUS YVYGVLFSLAE???K?ERLA?R??RLP?E???????VI?KEW?AYKGKSPQTPELV?AL?

F120A_XENTR F120A_XENTR FREWTCPNLKKLWLGKAVEDKNRRMRAFLACMRSDTPAMLNPANVPTHLMVLCCVLRYMV B2KI98_RHIFE B2KI98_RHIFE FREWTCPNLKRLWLGKAVEDKNRRMRAFLACMRSDTPAMLNPASVPTHLTVLCCVLRYMV F120A_BOVIN F120A_BOVIN FREWTCPNLKRLWLGKAVEDKNRRMRAFLACMRSDTPAMLNPASVPTHLTVLCCVLRYMV F120A_MOUSE F120A_MOUSE FREWTCPNLKRLWLGKAVEDKNRRMRAFLACMRSDTPAMLNPANVPTHLMVLCCVLRYMV F120A_HUMAN F120A_HUMAN FREWTCPNLKRLWLGKAVEDKNRRMRAFLACMRSDTPAMLNPANVPTHLMVLCCVLRYMV Q4S6D5_TETNG Q4S6D5_TETNG FREWTCPNLRRLWLGRASEDRSRRTRAFLACLRSDCPALLNPAQVPQHLLLMCCVLRYIM B1AQ10_HUMAN B1AQ10_HUMAN FREWTCPNLKKLWLGKAVEDKNRRMRAFLACMKSDTPSMLNPANVPTHLLLMCCVLRYMV F120C_HUMAN F120C_HUMAN FREWTCPNLKKLWLGKAVEDKNRRMRAFLACMKSDTPSMLNPANVPTHLLLMCCVLRYMV B7ZW94_MOUSE B7ZW94_MOUSE FREWTCPNLKKLWLGKAVEDKNRRMRAFLACMKSDTPSMLNPANVPTHLLLMCCVLRYMV Q3V3X9_MOUSE Q3V3X9_MOUSE FREWTCPNLKKLWLGKAVEDKNRRMRAFLACMKSDTPSMLNPANVPTHLLLMCCVLRYMV F120C_MOUSE F120C_MOUSE FREWTCPNLKKLWLGKAVEDRNRRMRAFLACMKSDTPSMLNPANVPTHLLLMCCVLRYMV Q3U0F6_MOUSE Q3U0F6_MOUSE FREWTCPNLKKLWLGKAVEDKNRRMRAFLACMKSDTPSMLNPANVPTHLLLMCCVLRYMV MATCH *********::****:* **:.** ******::** *::****.** ** ::******:: CONSENSUS FREWTCPNLK?LWLGKAVEDKNRRMRAFLACM?SDTP?MLNPA?VPTHL???CCVLRYMV

F120A_XENTR F120A_XENTR QWPGIRILRRQELDAFLAQAISPKLYEPDQLQELK------------------------- B2KI98_RHIFE B2KI98_RHIFE QWPGARILRRQELDAFLAQALSPKLYEPDQLQELK------------------------- F120A_BOVIN F120A_BOVIN QWPGARILRRQELDAFLAQALSPKLYEPDQLQELK------------------------- F120A_MOUSE F120A_MOUSE QWPGARILRRQELDAFLAQALSPKLYEPDQLQELK------------------------- F120A_HUMAN F120A_HUMAN QWPGARILRRQELDAFLAQALSPKLYEPDQLQELK------------------------- Q4S6D5_TETNG Q4S6D5_TETNG QWPGGRILQRHELDAFLAQAVSNQLYEPDQLQELKVSPSSRPVLKAPGPDADAGFSPFSS B1AQ10_HUMAN B1AQ10_HUMAN QWPGGRILHRHELDTFLAQAVSTQLYEPDRLQELK------------------------- F120C_HUMAN F120C_HUMAN QWPGGRILHRHELDTFLAQAVSTQLYEPDRLQELK------------------------- B7ZW94_MOUSE B7ZW94_MOUSE QWPGGRILHRHELDTFLAQAVSTQLYEPDQLQELK------------------------- Q3V3X9_MOUSE Q3V3X9_MOUSE QWPGGRILHRHELDTFLAQAVSTQLYEPDQLQELK------------------------- F120C_MOUSE F120C_MOUSE QWPGGRILHRHELDTFLAQAVSTQLYEPDQLQELK------------------------- Q3U0F6_MOUSE Q3U0F6_MOUSE QWPGGRILHRHELDTFLAQAVSTQLYEPDQLQELK------------------------- MATCH **** ***:*:***:*****:* :*****:***** CONSENSUS QWPG?RIL?R?ELD?FLAQA?S??LYEPDQLQELK?????????????????????????

F120A_XENTR F120A_XENTR --IDNLDPRGIQLSALFMSGVDMAFLANDACGQPIPWEHCCPWMYFDGKLLQAKLNKATR B2KI98_RHIFE B2KI98_RHIFE --IENLDPRGIQLSALFMSGVDMALFANDACGQPVPWEHCCPWMYFDGKLFQSKLLKASR F120A_BOVIN F120A_BOVIN --IENLDPRGIQLSALFMSGVDMALFANDACGQPVPWEHCCPWMYFDGKLFQSKLLKASR F120A_MOUSE F120A_MOUSE --IDNLDPRGIQLSALFMSGVDMALFANDACGQPIPWEHCCPWMYFDGKLFQSKLLKASR F120A_HUMAN F120A_HUMAN --IENLDPRGIQLSALFMSGVDMALFANDACGQPIPWEHCCPWMYFDGKLFQSKLLKASR Q4S6D5_TETNG Q4S6D5_TETNG CQVEKVDARGVQLASLFMAGVDTALFINDVCGQPLPWEHCCPWGFFDGKLFQSKLARAAR B1AQ10_HUMAN B1AQ10_HUMAN --IEKLDARGIQLAALFMSGVDTALFANDACGQPVPWEHCCPWIYFDGKLFQSKLIKAGR F120C_HUMAN F120C_HUMAN --IEKLDARGIQLAALFMSGVDTALFANDACGQPVPWEHCCPWIYFDGKLFQSKLIKAGR B7ZW94_MOUSE B7ZW94_MOUSE --IEKLDARGIQLAALFMSGVDTALFANDACGQPVPWEHCCPCIYFDGKLFQSKLIKAGR Q3V3X9_MOUSE Q3V3X9_MOUSE --IEKLDARGIQLAALFMSGVDTALFANDACGQPVPWEHCCPWIYFDGKLFQSKLIKAGR F120C_MOUSE F120C_MOUSE --IEKLDARGIQLAALFMSGVDTALFANDACGQPVPWEHCCPWIYFDGKLFQSKLIKAGR Q3U0F6_MOUSE Q3U0F6_MOUSE --IEKLDARGIQLAALFMSGVDTALFANDACGQPVPWEHCCPWIYFDGKLFQSKLIKAGR MATCH ::::*.**:**::***:*** *:: **.****:******* :*****:*:** :* * CONSENSUS ??IE?LD?RGIQL?ALFMSGVD?ALFANDACGQP?PWEHCCPW?YFDGKLFQSKL?KA?R

F120A_XENTR F120A_XENTR EKASLIDLCDGQVELATKVEKMRQSILEGLHFSRQNHPLPFPPPPAMP-----FYPAAMY B2KI98_RHIFE B2KI98_RHIFE EKTPLIDLCDGQAEQAAKVEKMRQSILEGLNFSRQSLPLPFPPPSALP-----FYPASVY F120A_BOVIN F120A_BOVIN EKTPLIDLCDGQAEQAAKVEKMRQSILEGLNFSRQSHPLPFPPPAALP-----FYPTSVY F120A_MOUSE F120A_MOUSE EKTPLIDLCDGQAEQAAKVEKMRQSILEGLSFSRQNHPLPFPPPPALP-----FYPASVY F120A_HUMAN F120A_HUMAN EKTPLIDLCDGQADQAAKVEKMRQSVLEGLSFSRQSHTLPFPPPPALP-----FYPASAY Q4S6D5_TETNG Q4S6D5_TETNG DRSALLDMCEG------------------------------------------------- B1AQ10_HUMAN B1AQ10_HUMAN ERVSLVELCDGQADLATKVEKMRQSILEGVNMNHPPPSALLPSPTFVPPMVPSLYPVSLY F120C_HUMAN F120C_HUMAN ERVSLVELCDGQADLATKVEKMRQSILEGVNMNHPPPSALLPSPTFVPPMVPSLYPVSLY B7ZW94_MOUSE B7ZW94_MOUSE ERVSLVELCDGQADLASKVEKMRQSILEGVNMNHPPPSALLPSPTFVPPMVPSLYPVSLY Q3V3X9_MOUSE Q3V3X9_MOUSE ERVSLVELCDGQADLASKVEKMRQSILEGVNMNHPPPSALLPSPTFVPPMVPSLYPVSLY F120C_MOUSE F120C_MOUSE ERVSLVELCDGQADLASKVEKMRQSILEGVNMNHPPPSALLPSPTFVPPMVPSLYPVSLY Q3U0F6_MOUSE Q3U0F6_MOUSE ERVSLVELCDGQADLASKVEKMRQSILEGVNMNHPPPSALLPSPTFVPPMVPSLYPVSLY MATCH :: .*:::*:* CONSENSUS E???L??LCDGQA??A?KVEKMRQSILEG????????????P?P???P??????YP?S?Y

F120A_XENTR F120A_XENTR PRPCGPMP-PPQGRGRGFP----------------------------------------- B2KI98_RHIFE B2KI98_RHIFE PRHFGPVP-PAQGRGRGFAGVCGFGGPYGETVATGAYRAFRVATAAGHCGAFSGTDGSRT F120A_BOVIN F120A_BOVIN PRHFGPVP-PAQGRGRGFAGVCGFGSPYGETVATGAYRAFRVATATGHCGAFSGSDSSRT F120A_MOUSE F120A_MOUSE PRHFGPVP-PSQGRGRGFAGVCGFGGHYGETVATGPYRAFRVTAASGHCGAFSGSDSSRT F120A_HUMAN F120A_HUMAN PRHFGPVP-PSQGRGRGFAGVCGFGGPYGETVATGPYRAFRVAAASGHCGAFSGSDSSRT Q4S6D5_TETNG Q4S6D5_TETNG ------------------------------------------------------------ B1AQ10_HUMAN B1AQ10_HUMAN SRAMGSMPLPPQGRSRGFA----------------------------------------- F120C_HUMAN F120C_HUMAN SRAMGSMPLPPQGRSRGFA----------------------------------------- B7ZW94_MOUSE B7ZW94_MOUSE SRAMGSFPPPPQARSRGFA----------------------------------------- Q3V3X9_MOUSE Q3V3X9_MOUSE SRAMGSFPPPPQARSRGFA----------------------------------------- F120C_MOUSE F120C_MOUSE SRAMGSFPPPPQARSRGFA----------------------------------------- Q3U0F6_MOUSE Q3U0F6_MOUSE SRAMGSFPPPPQARSRGFA----------------------------------------- MATCH CONSENSUS ?R??G??P?P?Q?R?RGFA?????????????????????????????????????????

F120A_XENTR F120A_XENTR -----GVQPMPSQGGKLEIAGTVVGQWAGTRRGR-GRGPFPLQVVSVGGANRGRPRGVIS B2KI98_RHIFE B2KI98_RHIFE SKSQGGIQPIPSQGGKLEIVGTVVGHWAGSRRGRGGRGPFPLQVVSVGGPARGRPRGVIS F120A_BOVIN F120A_BOVIN SKSQGGIQPIPSQGGKLEIAGTVVGHWAGSRRGRGGRGPFPLQVVSVGGPARGRPRGVIS F120A_MOUSE F120A_MOUSE SKSQGGVQPIPSQGGKLEIAGTVVGHWAGSRRGRGGRGPFPLQVVSVGGPARGRPRGVIS F120A_HUMAN F120A_HUMAN SKSQGGVQPIPSQGGKLEIAGTVVGHWAGSRRGRGGRGPFPLQVVSVGGPARGRPRGVIS Q4S6D5_TETNG Q4S6D5_TETNG ------------QGGKLEIAGMVVGQWAGNKPVR-GRGGLNMQVVSVGA-GRGRGKEVPA B1AQ10_HUMAN B1AQ10_HUMAN -----GLHPIPPQGGKLEIAGMVVGQWAGSRSSR-GRGSFGMQVVSVGGPGKGHGKEQT- F120C_HUMAN F120C_HUMAN -----GLHPIPPQGGKLEIAGMVVGQWAGSRSSR-GRGSFGMQVVSVGGPGKGHGKEQT- B7ZW94_MOUSE B7ZW94_MOUSE -----GLHPIPPQGGKLEIAGMVVGQWAGSRSSR-SRGSFGMQVVSVGGPGKGHGKEQA- Q3V3X9_MOUSE Q3V3X9_MOUSE -----GLHPIPPQGGKLEIAGMVVGQWAGSRSSR-SRGSFGMQVVSVGGPGKGHGKEQA- F120C_MOUSE F120C_MOUSE -----GLHPIPPQGGKLEIAGMVVGQWAGSRSSR-SRGSFGMQVVSVGGPGKGHGKEQA- Q3U0F6_MOUSE Q3U0F6_MOUSE -----GLHPIPPQGGKLEIAGMVVGQWAGSRSSR-SRGSFGMQVVSVGGPGKGHGKEQA- MATCH *******.* ***:***.: * .** : :******. :*: : CONSENSUS ?????G??PIP?QGGKLEIAG?VVG?WAGSR??R??RG?F??QVVSVGGP??G???????

F120A_XENTR F120A_XENTR TPIIRTFGRGGRYYGRGFKNQGPPQAKPPYATSAEEVAKELKTQSEDSKSSAVSSDGSLA B2KI98_RHIFE B2KI98_RHIFE TPVIRTFGRGGRYYGRGYKNQGAIQGKPPYAASAEEVAKELKSRSGESKSSALSSDGSLA F120A_BOVIN F120A_BOVIN TPVIRTFGRGGRYYGRGYKNQGAIQGKPPYAASAEEVAKELKSRSGESKSSAMSSDGSLA F120A_MOUSE F120A_MOUSE TPVIRTFGRGGRYYGRGYKSQGAIQGRPPYAASAEEVAKELKSKSGESKSSAV----SLA F120A_HUMAN F120A_HUMAN TPVIRTFGRGGRYYGRGYKNQAAIQGRPPYAASAEEVAKELKSKSGESKSSAMSSDGSLA Q4S6D5_TETNG Q4S6D5_TETNG K------LRGVKKMPTNRTQ----TSSPPSSSPPPKLSEETSSTPEVAAQQLNGSAAASA B1AQ10_HUMAN B1AQ10_HUMAN -------GRGSKGHKKGNKQ-----------GSSDGVSKSLELHQGRSRSQVNGNSGAL- F120C_HUMAN F120C_HUMAN -------GRGSKGHKKGNKQ-----------GSSDGVSKSLELHQGRSRSQVNGNSGAL- B7ZW94_MOUSE B7ZW94_MOUSE -------GRGSKGHKKGNKQ-----------GSSDVISKAVELHQSRARSQVNGNNGTL- Q3V3X9_MOUSE Q3V3X9_MOUSE -------GRGSKG----------------------------------------------- F120C_MOUSE F120C_MOUSE -------GRGSKGHKKGNKQ-----------GSSDVISKAVELHQSRARSQVNGNNGTL- Q3U0F6_MOUSE Q3U0F6_MOUSE -------GRGSKGHKKGNKQ-----------GSSDVISKAVELHQSRARSQVNGNNGTL- MATCH ** : CONSENSUS ???????GRG??????G?K?????????????S?????K??????????S????????L?

F120A_XENTR F120A_XENTR ENGLASEEAPASQMNGGSGEARASSNSESALSSDSKLCNT--NPHLNALNADSVRHKEQP B2KI98_RHIFE B2KI98_RHIFE ENGAVAEEKPASQMNGSAGDARAPSHSESALNNDSKMCNT--NPHLNALSTDSACRGADA F120A_BOVIN F120A_BOVIN ENGVVAEEKPAPQMNGSAGDTRAPSHSESALNNDSKTCNT--NPHLNALSTDSGCRRADA F120A_MOUSE F120A_MOUSE ENGVMAEEKPVPQLNGSTGDPRVPSHSESALNNDSKPCNT--NPHLNALSTDSACRREAA F120A_HUMAN F120A_HUMAN ENGVMAEEKPAPQMNGSTGDARAPSHSESALNNDSKTCNT--NPHLNALSTDSACRREAA Q4S6D5_TETNG Q4S6D5_TETNG ----IGQSLE---------LTSLAQPIPCALASRDNQSEG--------EEVEAPCCLDDC B1AQ10_HUMAN B1AQ10_HUMAN ----IKEEKS---------DHRLPAPSQCALSRDSNECNN-GNRYLPMNNREKNHLQEQK F120C_HUMAN F120C_HUMAN ----IKEEKS---------DHRLPAPSQCALSRDSNECNN-GNRYLPMNNREKNHLQEQK B7ZW94_MOUSE B7ZW94_MOUSE ----IVEEKS---------D-PLPAPSQCALSRDSNECNNSDDHCLPVKNGEKNHVPEQE Q3V3X9_MOUSE Q3V3X9_MOUSE ------------------------------------------------------------ F120C_MOUSE F120C_MOUSE ----IVEEKS---------D-PLPAPSQCALSRDSNECNNSDDHCLPVKNGEKNHVPEQE Q3U0F6_MOUSE Q3U0F6_MOUSE ----IVEEKS---------D-PLPAPSQCALSRDSNECNNSDDHCLPVKNGEKNHVPEQE MATCH CONSENSUS ??????EE??????????????????S??AL??DS??CN??????L??????????????

F120A_XENTR F120A_XENTR LEGAVANKEE B2KI98_RHIFE B2KI98_RHIFE LGAAVLKQEE F120A_BOVIN F120A_BOVIN LEAAVLKKEE F120A_MOUSE F120A_MOUSE LEAAVLNKEE F120A_HUMAN F120A_HUMAN LEAAVLNKEE Q4S6D5_TETNG Q4S6D5_TETNG PSDGALQKEE B1AQ10_HUMAN B1AQ10_HUMAN LETVAQRKED F120C_HUMAN F120C_HUMAN LETVAQRKED B7ZW94_MOUSE B7ZW94_MOUSE LEAVAQQKEE Q3V3X9_MOUSE Q3V3X9_MOUSE ---------- F120C_MOUSE F120C_MOUSE LEAVAQQKEE Q3U0F6_MOUSE Q3U0F6_MOUSE LEAVAQQKEE MATCH CONSENSUS L??????KE?


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