Alignment of the gene Family HBG051040 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
B8JL72_DANRE B8JL72_DANRE ---------------------LDDCLLQYMRTFEREQITGEQLLHITHQELEELGVTRIG Q4RTB1_TETNG Q4RTB1_TETNG ALVMEPISKWTPKQVLDWMKGLDDCLQQYVKNFEREQMGGEQLLHITHQELEELGVTRIG Q4S8W9_TETNG Q4S8W9_TETNG ALVMEPVSKWSSGQVVDWMKGLDDCLQQYIKTFEKEKVGGDQLLRITHQELEDLGVSRIG CNKR2_RAT CNKR2_RAT ALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIG Q3URG0_MOUSE Q3URG0_MOUSE ALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIG A2AI77_MOUSE A2AI77_MOUSE ALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIG CNKR2_MOUSE CNKR2_MOUSE ALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIG A2AI78_MOUSE A2AI78_MOUSE ALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIG B3KPN2_HUMAN B3KPN2_HUMAN ------------------------------------------------------------ Q5R7V6_PONAB Q5R7V6_PONAB ALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIG B7ZLJ1_HUMAN B7ZLJ1_HUMAN ALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIG B4DGR4_HUMAN B4DGR4_HUMAN ALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIG CNKR2_HUMAN CNKR2_HUMAN ALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIG Q5JPN0_HUMAN Q5JPN0_HUMAN ALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIG A4IJ08_XENTR A4IJ08_XENTR ALIMEPVSKWTPSQVVDWMKGLDDCLQQYIKNFEREKIAGDQLLRITHQELEELGVTRIG Q6GQI9_XENLA Q6GQI9_XENLA ALIMEPVSKWTPSQVVDWMKGLDDCLQQYIKNFEREKIAGDQLLRITHQELEELGVTRIG B5DE81_XENTR B5DE81_XENTR ---MEPVTKWSPIQVVEWMKGLDDCLLQYVTNVEREKINGEQLLKFTHQDLQELGITQIQ CNKR3_HUMAN CNKR3_HUMAN ---MEPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIG CNKR3_MOUSE CNKR3_MOUSE ---MEPVTKWSPKQVVDWTRGLDDCLQPYVHKFEREKIDGEQLLKISHQDLEELGVTRIG CNKR3_RAT CNKR3_RAT ---MEPVTKWSPKQVVDWTRGLDDCLQPYVHKFEREKIDGEQLLKISHQDLEELGVTRIG Q4RP02_TETNG Q4RP02_TETNG --------------------GLDDSLQQYVSNFEREKISGEQLLKITHQDLEELGLARIG A8WG10_DANRE A8WG10_DANRE ---MEPITKWTAAQVVDWIRGLDDSLQQYISNFEREKISGERLLKISHQELEELSVTRVG MATCH CONSENSUS ???MEP??KW???QVVDW??GLDDCLQQY???FEREKI?G?QLL?I?HQ?LE?LGV?RIG

B8JL72_DANRE B8JL72_DANRE HQELILEAVD-LLCA------------------LNYGLETENLRTLSHKLNASAKNLQNF Q4RTB1_TETNG Q4RTB1_TETNG HQELILEA--------------------------NYGLETENLRTLSHKLNASAKNLQNF Q4S8W9_TETNG Q4S8W9_TETNG HQELILEAVGPTLCSGKVEKKVEQGSYG-SCFLVNYGLETENLKTLSHKLNASAKNLQNF CNKR2_RAT CNKR2_RAT HQELILEAVD-LLCA------------------LNYGLETENLKTLSHKLNASAKNLQNF Q3URG0_MOUSE Q3URG0_MOUSE HQELILEAVD-LLCA------------------LNYGLETENLKTLSHKLNASAKNLQNF A2AI77_MOUSE A2AI77_MOUSE HQELILEAVD-LLCA------------------LNYGLETENLKTLSHKLNASAKNLQNF CNKR2_MOUSE CNKR2_MOUSE HQELILEAVD-LLCA------------------LNYGLETENLKTLSHKLNASAKNLQNF A2AI78_MOUSE A2AI78_MOUSE HQELILEAVD-LLCA------------------LNYGLETENLKTLSHKLNASAKNLQNF B3KPN2_HUMAN B3KPN2_HUMAN ------------------------------------------------------------ Q5R7V6_PONAB Q5R7V6_PONAB HQELILEAVD-LLCA------------------LNYGLETENLKTLSHKLNASAKNLQNF B7ZLJ1_HUMAN B7ZLJ1_HUMAN HQELILEAVD-LLCA------------------LNYGLETENLKTLSHKLNASAKNLQNF B4DGR4_HUMAN B4DGR4_HUMAN HQELILEAVD-LLCA------------------LNYGLETENLKTLSHKLNASAKNLQNF CNKR2_HUMAN CNKR2_HUMAN HQELILEAVD-LLCA------------------LNYGLETENLKTLSHKLNASAKNLQNF Q5JPN0_HUMAN Q5JPN0_HUMAN HQELILEAVD-LLCA------------------LNYGLETENLKTLSHKLNASAKNLQNF A4IJ08_XENTR A4IJ08_XENTR HQELILEAVD-LLCA------------------LNYGLETENLKTLSHKLNSSAKNLQNF Q6GQI9_XENLA Q6GQI9_XENLA HQELILEAVD-LLCA------------------LNYGLETENLKTLSHKLNSSAKNLQNF B5DE81_XENTR B5DE81_XENTR HQELVLEAVD-LLCA------------------LNYGLEMDSMKNTVLKLRSSSNNLQNY CNKR3_HUMAN CNKR3_HUMAN HQELVLEAVD-LLCA------------------LNYGLETDNMKNLVLKLRASSHNLQNY CNKR3_MOUSE CNKR3_MOUSE HQELVLEAVD-LLCA------------------LNYGLETDTMKNLVLKLRASSHNLQNY CNKR3_RAT CNKR3_RAT HQELVLEAVD-LLCA------------------LNYGLETDNMKNLVLKLRASSHNLQNY Q4RP02_TETNG Q4RP02_TETNG HQELVLEAVD-LLCALVAERHMDIKSKQIHTAPVNYGVETDNLKGLVVRMRAATSNLQKA A8WG10_DANRE A8WG10_DANRE HQELILEAVD-LLCA------------------LNCGVETDNLKTLVGQMRAASNNLQNC MATCH CONSENSUS HQEL?LEAVD?LLCA??????????????????LNYGLET?N?K?L??KL?AS??NLQN?

B8JL72_DANRE B8JL72_DANRE ITGRRRGGHYDGRVSRRLPNDFLTSVVDLIGAAKNLLAWLDR------------------ Q4RTB1_TETNG Q4RTB1_TETNG ILGRRRGGHYDGRASRRLPNDFLTSVVDLIGAAKNLLAWLDR------------------ Q4S8W9_TETNG Q4S8W9_TETNG ITGRRRSGHYDGRATRKLPNDFLTSVVDLIAAAKSLLAWLDR------------------ CNKR2_RAT CNKR2_RAT ITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDR------------------ Q3URG0_MOUSE Q3URG0_MOUSE ITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDR------------------ A2AI77_MOUSE A2AI77_MOUSE ITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDR------------------ CNKR2_MOUSE CNKR2_MOUSE ITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDR------------------ A2AI78_MOUSE A2AI78_MOUSE ITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDR------------------ B3KPN2_HUMAN B3KPN2_HUMAN ------------------------------------------------------------ Q5R7V6_PONAB Q5R7V6_PONAB ITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDR------------------ B7ZLJ1_HUMAN B7ZLJ1_HUMAN ITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDR------------------ B4DGR4_HUMAN B4DGR4_HUMAN ITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDR------------------ CNKR2_HUMAN CNKR2_HUMAN ITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDR------------------ Q5JPN0_HUMAN Q5JPN0_HUMAN ITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDR------------------ A4IJ08_XENTR A4IJ08_XENTR ITGRRRSGHYDGKSSRKLPNDFLTSVVDLIGSAKSLLAWLDRYCHADQDDIDNLKKRWIG Q6GQI9_XENLA Q6GQI9_XENLA ITGRRRSGHYDGKSSRKLPNDFLTSVVDLIGSAKSLLAWLDR------------------ B5DE81_XENTR B5DE81_XENTR IGNQKKSASYDSNTSHKPHNDFLTSAVELIGSAKALLTCLER------------------ CNKR3_HUMAN CNKR3_HUMAN ISSRRKSPAYDGNTSRKAPNEFLTSVVELIGAAKALLAWLDR------------------ CNKR3_MOUSE CNKR3_MOUSE ISSRRKSPAYDGNTSRKPPNEFLTSVVELIGAAKALLAWLDR------------------ CNKR3_RAT CNKR3_RAT ISSRRKSPAYDGNTSRKPPNEFLTSVVELIGAAKALLAWLDR------------------ Q4RP02_TETNG Q4RP02_TETNG ISERRASPTYDGGTSRNRP-------------TTSSPPW--------------------- A8WG10_DANRE A8WG10_DANRE ASERRKNPSYDGGSPNKPPNVFLTAVVELIGAAKSMLAWLDR------------------ MATCH CONSENSUS I??RR?S??YDG??SRK?PN?FLTSVV?LIG?AK?LLAWLDR??????????????????

B8JL72_DANRE B8JL72_DANRE -----SPFVSVSEYSVLKNNIVQLCLELTTIVQQ-------------------------D Q4RTB1_TETNG Q4RTB1_TETNG -----SPFSSVTEYSLLKNNIVQLCLELTTIVQQ-------------------------D Q4S8W9_TETNG Q4S8W9_TETNG -----SPFAAVADYSVTRNNVIQLCLELTTIVQQ-------------------------D CNKR2_RAT CNKR2_RAT -----SPFAAVTDYSVTRNNVIQLCLELTTIVQQ-------------------------D Q3URG0_MOUSE Q3URG0_MOUSE -----SPFAAVTDYSVTRNNVIQLCLELTTIVQQ-------------------------D A2AI77_MOUSE A2AI77_MOUSE -----SPFAAVTDYSVTRNNVIQLCLELTTIVQQ-------------------------D CNKR2_MOUSE CNKR2_MOUSE -----SPFAAVTDYSVTRNNVIQLCLELTTIVQQ-------------------------D A2AI78_MOUSE A2AI78_MOUSE -----SPFAAVTDYSVTRNNVIQLCLELTTIVQQ-------------------------D B3KPN2_HUMAN B3KPN2_HUMAN ------------------------------------------------------------ Q5R7V6_PONAB Q5R7V6_PONAB -----SPFAAVTDYSVTRNNVIQLCLELTTIVQQ-------------------------D B7ZLJ1_HUMAN B7ZLJ1_HUMAN -----SPFAAVTDYSVTRNNVIQLCLELTTIVQQ-------------------------D B4DGR4_HUMAN B4DGR4_HUMAN -----SPFAAVTDYSVTRNNVIQLCLELTTIVQQ-------------------------D CNKR2_HUMAN CNKR2_HUMAN -----SPFAAVTDYSVTRNNVIQLCLELTTIVQQ-------------------------D Q5JPN0_HUMAN Q5JPN0_HUMAN -----SPFAAVTDYSVTRNNVIQLCLELTTIVQQ-------------------------D A4IJ08_XENTR A4IJ08_XENTR HKLDKSPFAAVTDYSVTRNNVIQLCLELTTIVQQ-------------------------E Q6GQI9_XENLA Q6GQI9_XENLA -----SPFAAVTDYSVTRNNVIQLCLELTTIVQQ-------------------------E B5DE81_XENTR B5DE81_XENTR -----APFTEITDLSSTKNKIIQLCLDLTTTVQQ-------------------------E CNKR3_HUMAN CNKR3_HUMAN -----APFTGITDFSVTKNKIIQLCLDLTTTVQK-------------------------D CNKR3_MOUSE CNKR3_MOUSE -----APFTGITDLSVTKNKIIQLCLDLTTAVQK-------------------------D CNKR3_RAT CNKR3_RAT -----APFTGITDLSVTKNKIIQLCLDLTTAVQK-------------------------D Q4RP02_TETNG Q4RP02_TETNG -----TPLTGISDFTTTKNKIIHLCLELTTTVQQLMRRPPKEGVFHIKLLPFRVSKNPPD A8WG10_DANRE A8WG10_DANRE -----SPLTGVSDFTTTKNKIIQLCLELTTTVQK-------------------------D MATCH CONSENSUS ??????PF????D?S?T?N??IQLCL?LTT?VQ??????????????????????????D

B8JL72_DANRE B8JL72_DANRE CTVYETENKILHVCKTLSGICEHIISLSSDSLVSQSAHLEVVHLTNVMPSEGLGMYIKST Q4RTB1_TETNG Q4RTB1_TETNG CTVYETENKILHVCKTLAGICDHIISLSSDSLVSQSAHLEVVHLTSIPPSEGLGMYIKST Q4S8W9_TETNG Q4S8W9_TETNG CSVYETENKILHVCKTLSEVCDHIISLSSDPMVSQAAHLEVVQLANIKSTEGLGMYIKST CNKR2_RAT CNKR2_RAT CTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKST Q3URG0_MOUSE Q3URG0_MOUSE CTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKST A2AI77_MOUSE A2AI77_MOUSE CTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKST CNKR2_MOUSE CNKR2_MOUSE CTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKST A2AI78_MOUSE A2AI78_MOUSE CTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKST B3KPN2_HUMAN B3KPN2_HUMAN ------------------------------------------------------------ Q5R7V6_PONAB Q5R7V6_PONAB CTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKST B7ZLJ1_HUMAN B7ZLJ1_HUMAN CTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKST B4DGR4_HUMAN B4DGR4_HUMAN CTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKST CNKR2_HUMAN CNKR2_HUMAN CTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKST Q5JPN0_HUMAN Q5JPN0_HUMAN CTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKST A4IJ08_XENTR A4IJ08_XENTR CTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLSNIKPSEGLGMYIKST Q6GQI9_XENLA Q6GQI9_XENLA CTVYETENKILHVCKTLSSVCDHIISLSSDPLVSQSAHLEVIQLSNIKPSEGLGMYIKST B5DE81_XENTR B5DE81_XENTR FSVEEVENTVLTVSKELNDICDKTIRLASDPLASHCACLEEVHMTNIKPGEGLGMYIKST CNKR3_HUMAN CNKR3_HUMAN CFVAEMEDKVLTVVKVLNGICDKTIRSTTDPVMSQCACLEEVHLPNIKPGEGLGMYIKST CNKR3_MOUSE CNKR3_MOUSE CLIAEMEDKVLNVVKVLNGICDKTMRSTTDPVMSQCACLEEVHLPNVRPGEGLGMYIKST CNKR3_RAT CNKR3_RAT CLVAEMEDKVLNVVKVLNGICDKMMHSTTDPVMSQCACLEEVHLPNVRPGEGLGMYIKST Q4RP02_TETNG Q4RP02_TETNG CSVYEMEEKILEVSKILSSICDQTVRTTSDPLMSQSACLQEVQLANIKPGEGLGMYIKST A8WG10_DANRE A8WG10_DANRE CTVFEMEEKILEVSQVLTGICDSTMRMTSDPLKTQVTCLEEVPISNIKPGEGLGMYIKST MATCH CONSENSUS C?V?E?E?K?L?V?K?L???CD??????SDP??SQ?A?LE???L?NI?P?EGLGMYIKST

B8JL72_DANRE B8JL72_DANRE YDGLHVITGTTENSPADQCKKIHAGDEVIQVNHQTVVGWQLKNLVNCLREDPSGVILTLK Q4RTB1_TETNG Q4RTB1_TETNG YDGLHVITGTTENSPADQCKKIHAGDEVIQVNHQTV-GWQLKNLVNALREDPCGVILTLK Q4S8W9_TETNG Q4S8W9_TETNG YDGLHVITGTTEGSLADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNLLRGDPAGVTLTLK CNKR2_RAT CNKR2_RAT YDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLK Q3URG0_MOUSE Q3URG0_MOUSE YDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTV------------------------ A2AI77_MOUSE A2AI77_MOUSE YDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLK CNKR2_MOUSE CNKR2_MOUSE YDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLK A2AI78_MOUSE A2AI78_MOUSE YDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLK B3KPN2_HUMAN B3KPN2_HUMAN ------------------------------------------------------------ Q5R7V6_PONAB Q5R7V6_PONAB YDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTV------------------------ B7ZLJ1_HUMAN B7ZLJ1_HUMAN YDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLK B4DGR4_HUMAN B4DGR4_HUMAN YDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTV------------------------ CNKR2_HUMAN CNKR2_HUMAN YDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLK Q5JPN0_HUMAN Q5JPN0_HUMAN YDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLK A4IJ08_XENTR A4IJ08_XENTR YDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLK Q6GQI9_XENLA Q6GQI9_XENLA YDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTV------------------------ B5DE81_XENTR B5DE81_XENTR YNGLHVITGTTENSAADRSGKVHAGDEVIQVNYHTVVGWQLKNLVARLRDNSGAVTLLLK CNKR3_HUMAN CNKR3_HUMAN YDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLK CNKR3_MOUSE CNKR3_MOUSE YDGLHVITGTTENSPADRSQKIHAGDEVIQVNRQTVVGWQLKNLVRKLRENPTGVVLLLK CNKR3_RAT CNKR3_RAT YDGLHVITGTTENSPADRSQKIHAGDEVIQVNRQTVVGWQLKNLVKKLRENPTGVVLLLK Q4RP02_TETNG Q4RP02_TETNG YDGLHVITGTTEHSPADLTRRIHAGDEVIQVNLQTVVGWQLKNLVVKLREDPKGVILLLK A8WG10_DANRE A8WG10_DANRE YDGLHVITGTTENSPADRTQRIHAGDEVIQVNKQTVVGWQLKNLVEKLREDPQNVTLMVK MATCH CONSENSUS YDGLHVITGTTENSPADR??KIHAGDEVIQVN?QTV????????????????????????

B8JL72_DANRE B8JL72_DANRE KRPQNTLGSTPALLKNARWKPLALQ---------------PL-STSPCSGSPTPPSTLGS Q4RTB1_TETNG Q4RTB1_TETNG KRPQNTLSSTPALLRNVRWKPLGLQ---------------PV-PTSPTSTSPTPGGTLGM Q4S8W9_TETNG Q4S8W9_TETNG KRPQSTLTSTPALLKNMRWKPLALQ---------------PIFPQSPSSSIPTPTSTLST CNKR2_RAT CNKR2_RAT KRPQSMLTSAPALLKNMRWKPLALQ---------------PLIPRSPTSSVATPSSTIST Q3URG0_MOUSE Q3URG0_MOUSE ----------------------------------------PLIPRSPTSSVATPSSTIST A2AI77_MOUSE A2AI77_MOUSE KRPQSMLTSAPALLKNMRWKPLALQ---------------PLIPRSPTSSVATPSSTIST CNKR2_MOUSE CNKR2_MOUSE KRPQSMLTSAPALLKNMRWKPLALQ---------------PLIPRSPTSSVATPSSTIST A2AI78_MOUSE A2AI78_MOUSE KRPQSMLTSAPALLKNMRWKPLALQ---------------PLIPRSPTSSVATPSSTIST B3KPN2_HUMAN B3KPN2_HUMAN ------------------------------------------------------------ Q5R7V6_PONAB Q5R7V6_PONAB ----------------------------------------PLIPRSPTSSVATPSSTIST B7ZLJ1_HUMAN B7ZLJ1_HUMAN KRPQSMLTSAPALLKNMRWKPLALQ---------------PLIPRSPTSSVATPSSTIST B4DGR4_HUMAN B4DGR4_HUMAN ----------------------------------------PLIPRSPTSSVATPSSTIST CNKR2_HUMAN CNKR2_HUMAN KRPQSMLTSAPALLKNMRWKPLALQ---------------PLIPRSPTSSVATPSSTIST Q5JPN0_HUMAN Q5JPN0_HUMAN KRPQSMLTSAPALLKNMRWKPLALQ---------------PLIPRSPTSSVATPSSTIST A4IJ08_XENTR A4IJ08_XENTR KRPQSMLTSAPALLKNMRWKPLALQWYDEEMKTYSWTRISPLIPRSPTSGAATPSSTIST Q6GQI9_XENLA Q6GQI9_XENLA ----------------------------------------PLISRSPTSGVATPSSTIST B5DE81_XENTR B5DE81_XENTR KRPTSSLNFTPAPLKNLRWRPQLVQ------------------TSHSPTAMQSPESTSNS CNKR3_HUMAN CNKR3_HUMAN KRPTGSFNFTPAPLKNLRWKPPLVQ------------------TSPPPATTQSPESTMDT CNKR3_MOUSE CNKR3_MOUSE KRPTGSFSFTPAPLKNLRWKPPLVQ------------------TSPPPTTTQSPESTMDA CNKR3_RAT CNKR3_RAT KRPTGSFSFTPAPLKNLRWKPPLVQ------------------TSPPPTTTQSPESTMDA Q4RP02_TETNG Q4RP02_TETNG KRPTSTTGFTPAPLKNMRWKPPVQQ------------------NNSSLIRTQSPSGSANK A8WG10_DANRE A8WG10_DANRE KRPSGTCSFTPAPLKNMRWRPPVIQ--------------------SPSFVPATQSSRHPV MATCH CONSENSUS ??????????????????????????????????????????????P??????P?ST???

B8JL72_DANRE B8JL72_DANRE VGLSPGVDTPGGHDVFILSPV---YGHREE-------DLDRGGFGV----FGSDSPGYYV Q4RTB1_TETNG Q4RTB1_TETNG ----SKMDAPSMQDVYILSPVSGLYSTREELGLMSCDDISRYSLSSQSGSKGSETVSYYL Q4S8W9_TETNG Q4S8W9_TETNG ---PSRRSSCALKDLYIPPPPSEPYTPRDEKGNMPVENTPADV---HVG-ERSESPNSYL CNKR2_RAT CNKR2_RAT ---PTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVH-KGSESPNSFL Q3URG0_MOUSE Q3URG0_MOUSE ---PTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVH-KGSESPNSFL A2AI77_MOUSE A2AI77_MOUSE ---PTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVH-KGSESPNSFL CNKR2_MOUSE CNKR2_MOUSE ---PTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVH-KGSESPNSFL A2AI78_MOUSE A2AI78_MOUSE ---PTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVH-KGSESPNSFL B3KPN2_HUMAN B3KPN2_HUMAN ------------------------------------------MVGKPVH-KGSESPNSFL Q5R7V6_PONAB Q5R7V6_PONAB ---PTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVH-KGSESPNSFL B7ZLJ1_HUMAN B7ZLJ1_HUMAN ---PTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVH-KGSESPNSFL B4DGR4_HUMAN B4DGR4_HUMAN ---PTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVH-KGSESPNSFL CNKR2_HUMAN CNKR2_HUMAN ---PTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVH-KGSESPNSFL Q5JPN0_HUMAN Q5JPN0_HUMAN ---PTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVH-KGSESPNSFL A4IJ08_XENTR A4IJ08_XENTR ---PTKRDSSALQDLFIPPPPPEPYIPRDEKGNLPCEDMTRHTVGKPVS-KGSESPNSFL Q6GQI9_XENLA Q6GQI9_XENLA ---PTKRDSSALQDLFIPPPPAEPYIPRDEKGNLPCEDMTRHTVGKPVS-KGSESPNSFL B5DE81_XENTR B5DE81_XENTR ---SLKKEKPAILDLYIPPPPSVPYFPRTEVGS---SGSNRCVYPIPGS-EGSESPNSFL CNKR3_HUMAN CNKR3_HUMAN ---SLKKEKSAILDLYIPPPPAVPYSPRDENGSFVYGGSSKCKQPLPGP-KGSESPNSFL CNKR3_MOUSE CNKR3_MOUSE ---SLKKEKPAILDLYIPPPPAVPYSPRDENVSFGYRGHSKSKQPLPVR-KGSESPNSFL CNKR3_RAT CNKR3_RAT ---SLKKEKPAILDLYIPPPPAVPYSPRDENVSFSYRGHTKSKQPLPGR-KGSESPNSFL Q4RP02_TETNG Q4RP02_TETNG ---LAKKEKPAILDLYIPPPPPVPYAPREVR-----MDTVSSISQRP---KGSESPNSFL A8WG10_DANRE A8WG10_DANRE QMSIRRPEKPAILDLYIPPPPSVPYSPRDAE--------KSEYAGVKMRPKGSESPNSSL MATCH *:: . : CONSENSUS ?????K????A??DLYIPPPP??PY?PR?E????????????????P???KGSESPNSFL

B8JL72_DANRE B8JL72_DANRE EQEVLGGQYFPLLEEES---------GRNTGLRRRDRTPTHSDLRQVSMGTE-------- Q4RTB1_TETNG Q4RTB1_TETNG DQD--SGQFFSLLEGDGPP-GPEYDRGRNTGVRRRDKTPTHGDLRPVSMPPEYNWMAEAK Q4S8W9_TETNG Q4S8W9_TETNG DQE--CRGRFPLVEEDSILYCYEYDQNQEVSSHRRDSTPTYGRLRPISMPVEYNWEADDE CNKR2_RAT CNKR2_RAT DQE--YRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYE Q3URG0_MOUSE Q3URG0_MOUSE DQE--YRKRFNIVEEDTVLYRYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYE A2AI77_MOUSE A2AI77_MOUSE DQE--YRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYE CNKR2_MOUSE CNKR2_MOUSE DQE--YRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYE A2AI78_MOUSE A2AI78_MOUSE DQE--YRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYE B3KPN2_HUMAN B3KPN2_HUMAN DQE--YRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTY------------------- Q5R7V6_PONAB Q5R7V6_PONAB DQE--YRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYE B7ZLJ1_HUMAN B7ZLJ1_HUMAN DQE--YRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTY------------------- B4DGR4_HUMAN B4DGR4_HUMAN DQE--YRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYE CNKR2_HUMAN CNKR2_HUMAN DQE--YRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYE Q5JPN0_HUMAN Q5JPN0_HUMAN DQE--YRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYE A4IJ08_XENTR A4IJ08_XENTR DQE--YRKHFNVVEEDAILYCYEYDKGRSGMQGRRESTPTYGKLRPISMPVEYNWVGDYE Q6GQI9_XENLA Q6GQI9_XENLA DQE--YRKHFNVVEEDAILYCYEYDKGRSGMQGRRESTPTYGKLRPISMPVEYNWVGDYE B5DE81_XENTR B5DE81_XENTR DHE--SRRRWFTIANSDQLFSSPLE-VKVQPAKLRDKTPSYGKPRPLSMPAEPSWMVPPE CNKR3_HUMAN CNKR3_HUMAN DQES-RRRRFTIADSDQLP-GYSVE-TNILPTKMREKTPSYGKPRPLSMPADGNWMGIVD CNKR3_MOUSE CNKR3_MOUSE DQES-QRRRFTIADSDQLP-GYSVE-TNVLPTKMRGKTPSYGKPRPLSMPADGNWMGIVD CNKR3_RAT CNKR3_RAT DQES-QRRRFTITDSDQLP-GYSVG-TNILPIKMRGKTPSYGKPRPLSMPADGNWMGIVD Q4RP02_TETNG Q4RP02_TETNG DLE--NRRR-TVTDYDKLNFGCPIE-ANVIQPKMREPKPSRGKPRPISMPADTC-LRVTD A8WG10_DANRE A8WG10_DANRE DLA--NRRRSNISDYNNKPTVQPAE-AAVPQARMRQRTPSRGKPRPVSMPVDTC-LGMSD MATCH : . * .*: CONSENSUS DQE???R?RF?????D??????????????????R??TP?YG??RP?SMP??????????

B8JL72_DANRE B8JL72_DANRE ------------------------------------------------------------ Q4RTB1_TETNG Q4RTB1_TETNG DPSMGKRGSRDSDNSLLRYLSDDKILVIEEEPEVPSRESRRDSTRRSRRKSRNPSSPS-F Q4S8W9_TETNG Q4S8W9_TETNG DLVKLKRESR-RENSLLRFASEDKTP---GEDFLLGRSLSQN-----RRKSDRGGGSAQY CNKR2_RAT CNKR2_RAT DPNKMKRDSR-RENSLLRYMSNEKIA---QEEYMFQRNSKKDTGKKSKKKGDKSTSPTHY Q3URG0_MOUSE Q3URG0_MOUSE DPNKMKRDSR-RENSLLRYMSNEKIA---QEEYMFQRNSKKDTGKKSKKKGDKSNSPAHY A2AI77_MOUSE A2AI77_MOUSE DPNKMKRDSR-RENSLLRYMSNEKIA---QEEYMFQRNSKKDTGKKSKKKGDKSNSPAHY CNKR2_MOUSE CNKR2_MOUSE DPNKMKRDSR-RENSLLRYMSNEKIA---QEEYMFQRNSKKDTGKKSKKKGDKSNSPAHY A2AI78_MOUSE A2AI78_MOUSE DPNKMKRDSR-RENSLLRYMSNEKIA---QEEYMFQRNSKKDTGKKSKKKGDKSNSPAHY B3KPN2_HUMAN B3KPN2_HUMAN ------------ENSLLRYMSNEKIA---QEEYMFQRNSKKDTGKKSKKKGDKSNSPTHY Q5R7V6_PONAB Q5R7V6_PONAB DPNKMKRDSR-RENSLLRYMSNEKIA---QEEYMFQRNSKKDTGKKSKKKGDKSNSPTHY B7ZLJ1_HUMAN B7ZLJ1_HUMAN ------------ENSLLRYMSNEKIA---QEEYMFQRNSKKDTGKKSKKKGDKSNSPTHY B4DGR4_HUMAN B4DGR4_HUMAN DPNKMKRDSR-RENSLLRYMSNEKIA---QEEYMFQRNSKKDTGKKSKKKGDKSNSPTHY CNKR2_HUMAN CNKR2_HUMAN DPNKMKRDSR-RENSLLRYMSNEKIA---QEEYMFQRNSKKDTGKKSKKKGDKSNSPTHY Q5JPN0_HUMAN Q5JPN0_HUMAN DPNKMKRDSR-RENSLLRYMSNEKIA---QEEYMFQRNSKKDTGKKSKKKGDKSNSPTHY A4IJ08_XENTR A4IJ08_XENTR DPNKIKRDSR-RESSLLRYISNDKVI---QEEYMLQRGTKKETGKKSKKKGEKNTSPSHY Q6GQI9_XENLA Q6GQI9_XENLA DPNKLKRDSR-RESSLLRYISNDKVI---QEEYMLQRGTKKDTGKKSKKKGEKNTSPSHY B5DE81_XENTR B5DE81_XENTR TYSRHRLAGKKGEGVLSRYFSNEQIT---------------------------------- CNKR3_HUMAN CNKR3_HUMAN PFARPRGHGRKGEDALCRYFSNERIP---------------------------------- CNKR3_MOUSE CNKR3_MOUSE PFAKPRGNGRKGEDALCRYFSNERIT---------------------------------- CNKR3_RAT CNKR3_RAT PFAKPRGHGRKGEDALCRYFSNERIT---------------------------------- Q4RP02_TETNG Q4RP02_TETNG PYARPWAQGRKGEDLLYRYLSNERIP---------------------------------- A8WG10_DANRE A8WG10_DANRE SPSRPWALGRKGDELLHRYLSNEQIP---------------------------------- MATCH CONSENSUS ?????????R??E??L?RY?SN??I???????????????????????????????????

B8JL72_DANRE B8JL72_DANRE ------------------------------------------------------------ Q4RTB1_TETNG Q4RTB1_TETNG PISPSMLSSTLRLDQPPDALPVRTESIANSF---HYTSLRTKTK--RRSKG--SLTSASR Q4S8W9_TETNG Q4S8W9_TETNG TLIPALQM-----EVS--TSSSDSASLYHVF---ERSSMRSRSK--KKSKAGSPVSSISK CNKR2_RAT CNKR2_RAT SLLPSLQMDALRQDIM--GTPVPETTLYHTF---QQSSLQHKSK--KKNKG--AIAGKSK Q3URG0_MOUSE Q3URG0_MOUSE SLLPSLQMDALRQDIM--GTPVPETTLYHTF---QQSSLQHKS----------------- A2AI77_MOUSE A2AI77_MOUSE SLLPSLQMDALRQDIM--GTPVPETTLYHTF---QQSSLQHKSK--KKNKG--AISGKSK CNKR2_MOUSE CNKR2_MOUSE SLLPSLQMDALRQDIM--GTPVPETTLYHTF---QQSSLQHKSK--KKNKG--AISGKSK A2AI78_MOUSE A2AI78_MOUSE SLLPSLQMDALRQDIM--GTPVPETTLYHTF---QQSSLQHKSK--KKNKG--AISGKSK B3KPN2_HUMAN B3KPN2_HUMAN SLLPSLQMDALRQDIM--GTPVPETTLYHTF---QQSSLQHKSK--KKNKG--PIAGKSK Q5R7V6_PONAB Q5R7V6_PONAB SLLPSLQMDALRQDIM--GTPVPETTLYHTF---QQSSLQHKSK--KKNKG--PIAGKSK B7ZLJ1_HUMAN B7ZLJ1_HUMAN SLLPSLQMDALRQDIM--GTPVPETTLYHTF---QQSSLQHKSK--KKNKG--PIAGKSK B4DGR4_HUMAN B4DGR4_HUMAN SLLPSLQMDALRQDIM--GTPVPETTLYHTF---QQSSLQHKSK--KKNKG--PIAGKSK CNKR2_HUMAN CNKR2_HUMAN SLLPSLQMDALRQDIM--GTPVPETTLYHTF---QQSSLQHKSK--KKNKG--PIAGKSK Q5JPN0_HUMAN Q5JPN0_HUMAN SLLPSLQMDALRQDIM--GTPVPETTLYHTF---QQSSLQHKSK--KKNKG--PIAGKSK A4IJ08_XENTR A4IJ08_XENTR ALIPAVQMDSLCHEVV--SPSVSDAASYHTF---QQSSLQHKSK--KRNKG--PVPGKSK Q6GQI9_XENLA Q6GQI9_XENLA ALIPAVQMDSLCHDVV--NSSVSDAASYHTF---QQSSLQHKSK--KRNKG--PVSGKSK B5DE81_XENTR B5DE81_XENTR --------------------PITEENIYSCS-----NLTKPASR--RLVRG--------- CNKR3_HUMAN CNKR3_HUMAN --------------------PIIEESSSPPYRFSRPTTERHLVRGADYIRG--------- CNKR3_MOUSE CNKR3_MOUSE --------------------PITEESASPMYRFSRPLTERHLVRGADYIRG--------- CNKR3_RAT CNKR3_RAT --------------------PIIEESASPVYRFSRPLTERHLVRGADYIRG--------- Q4RP02_TETNG Q4RP02_TETNG ------------------TIAEELPSVSPPY---RPAGERHLIR-VDHIRG--------- A8WG10_DANRE A8WG10_DANRE ------------------TISEESPCYPLPY---RPAGERQLVRGVDHIRG--------- MATCH CONSENSUS ??????????????????????????????????????????????????G?????????

B8JL72_DANRE B8JL72_DANRE ------------------------------------------------------------ Q4RTB1_TETNG Q4RTB1_TETNG RRISCKDLGHGDCEGWLWKKKDAKGYFTQKWRKYWFILKESCLYWYTNQNDEKAEGFISL Q4S8W9_TETNG Q4S8W9_TETNG RRISCRDLGQGDCEGWLWKKKDAKTYFSQKWKKYWFILKDTCLYWYMNEEDEKAEGFVSL CNKR2_RAT CNKR2_RAT RRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISL Q3URG0_MOUSE Q3URG0_MOUSE ------------------------------------------------------------ A2AI77_MOUSE A2AI77_MOUSE RRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISL CNKR2_MOUSE CNKR2_MOUSE RRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISL A2AI78_MOUSE A2AI78_MOUSE RRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISL B3KPN2_HUMAN B3KPN2_HUMAN RRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISL Q5R7V6_PONAB Q5R7V6_PONAB RRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISL B7ZLJ1_HUMAN B7ZLJ1_HUMAN RRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISL B4DGR4_HUMAN B4DGR4_HUMAN RRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISL CNKR2_HUMAN CNKR2_HUMAN RRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISL Q5JPN0_HUMAN Q5JPN0_HUMAN RRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISL A4IJ08_XENTR A4IJ08_XENTR RRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFILKDTSLYWYINEEEEKAEGFISL Q6GQI9_XENLA Q6GQI9_XENLA RRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDTSLYWYTNEEEEKAEGFISL B5DE81_XENTR B5DE81_XENTR -----------------------ADYVRASPSLLNMDLHNSSTMPYQEDVEKKH------ CNKR3_HUMAN CNKR3_HUMAN ----------------------SRCYINSD-------LHSSATIPFQEEGTKKKSG---- CNKR3_MOUSE CNKR3_MOUSE ----------------------SRCYINSD-------LHSSATIPFQEEGSKKK------ CNKR3_RAT CNKR3_RAT ----------------------SRCYINSD-------LHSSATIPFQEEGPKKK------ Q4RP02_TETNG Q4RP02_TETNG -----------------------NRYFSNS------DLHNSATIPY-QEDARKA------ A8WG10_DANRE A8WG10_DANRE -----------------------SQCFINA------DLHNSATIPYQEAVARK------- MATCH CONSENSUS ?????????????????????????Y???????????L??????????????K???????

B8JL72_DANRE B8JL72_DANRE ------------------------------------------------------------ Q4RTB1_TETNG Q4RTB1_TETNG PEFRIDRAIECRRKFAFKACHPKIKSFFFATDCLEEMNR--------------------- Q4S8W9_TETNG Q4S8W9_TETNG PEFKIDRATECRRKYAFKACHPKIKTFYFAAENVDDMSRDWTPPVLAQRTGGFKPAATHS CNKR2_RAT CNKR2_RAT PEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNR--------------------- Q3URG0_MOUSE Q3URG0_MOUSE ------------------------------------------------------------ A2AI77_MOUSE A2AI77_MOUSE PEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNR--------------------- CNKR2_MOUSE CNKR2_MOUSE PEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNR--------------------- A2AI78_MOUSE A2AI78_MOUSE PEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNR--------------------- B3KPN2_HUMAN B3KPN2_HUMAN PEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNR--------------------- Q5R7V6_PONAB Q5R7V6_PONAB PEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNR--------------------- B7ZLJ1_HUMAN B7ZLJ1_HUMAN PEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNR--------------------- B4DGR4_HUMAN B4DGR4_HUMAN PEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNR--------------------- CNKR2_HUMAN CNKR2_HUMAN PEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNR--------------------- Q5JPN0_HUMAN Q5JPN0_HUMAN PEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNR--------------------- A4IJ08_XENTR A4IJ08_XENTR PEFKIDRASECRKKFAFKACHPKIKSFYFAADNLDDMNR--------------------- Q6GQI9_XENLA Q6GQI9_XENLA PEFKIDRASECRKKFAFKACHPKIKSFYFAADNLDDMSR--------------------- B5DE81_XENTR B5DE81_XENTR NASSSSKNSSTEPSFLVS------------------------------------------ CNKR3_HUMAN CNKR3_HUMAN --SSATKSSSTEPSLLVS------------------------------------------ CNKR3_MOUSE CNKR3_MOUSE SASSSAKASSGEPSLLVS------------------------------------------ CNKR3_RAT CNKR3_RAT SASSSAKASSGEPSLLVS------------------------------------------ Q4RP02_TETNG Q4RP02_TETNG PVAPVTKRTSAERSLLVS------------------------------------------ A8WG10_DANRE A8WG10_DANRE PASKSSKRPPSEPSVFSS------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

B8JL72_DANRE B8JL72_DANRE -------------------WLAEP------------------------------------ Q4RTB1_TETNG Q4RTB1_TETNG -------------------WMNRLGLAAIGYTPDDKVPRPDE------------------ Q4S8W9_TETNG Q4S8W9_TETNG RRHTSTLPSREFSSAAIPLWLSRLSMAVAGYPEQEKICQDQDNRMGRSVTLSEINTGCLF CNKR2_RAT CNKR2_RAT -------------------WLNRINMLTAGYAERERIKQEQ------------------- Q3URG0_MOUSE Q3URG0_MOUSE ------------------------------------------------------------ A2AI77_MOUSE A2AI77_MOUSE -------------------WLNRINMLTAGYAERERIKQEQ------------------- CNKR2_MOUSE CNKR2_MOUSE -------------------WLNRINMLTAGYAERERIKQEQ------------------- A2AI78_MOUSE A2AI78_MOUSE -------------------WLNRINMLTAGYAERERIKQEQ------------------- B3KPN2_HUMAN B3KPN2_HUMAN -------------------WLNRINMLTAGYAERERIKQEQ------------------- Q5R7V6_PONAB Q5R7V6_PONAB -------------------WLNRINMLTAGYAERERIKQEQ------------------- B7ZLJ1_HUMAN B7ZLJ1_HUMAN -------------------WLNRINMLTAGYAERERIKQEQ------------------- B4DGR4_HUMAN B4DGR4_HUMAN -------------------WLNRINMLTAGYAERERIKQEQ------------------- CNKR2_HUMAN CNKR2_HUMAN -------------------WLNRINMLTAGYAERERIKQEQ------------------- Q5JPN0_HUMAN Q5JPN0_HUMAN -------------------WLNRINMLTAGYAERERIKQEQ------------------- A4IJ08_XENTR A4IJ08_XENTR -------------------WLSRVNLAVSSYAERER------------------------ Q6GQI9_XENLA Q6GQI9_XENLA -------------------WLSRVNLAVSSYAERERIKQDQGS----------------- B5DE81_XENTR B5DE81_XENTR -------------------WFTKLKLLPR------------------------------- CNKR3_HUMAN CNKR3_HUMAN -------------------WFTRLKLLTH------------------------------- CNKR3_MOUSE CNKR3_MOUSE -------------------WLTRLKLLTH------------------------------- CNKR3_RAT CNKR3_RAT -------------------WLTRLKLLTH------------------------------- Q4RP02_TETNG Q4RP02_TETNG -------------------WITRLKLLTH------------------------------- A8WG10_DANRE A8WG10_DANRE -------------------WIARLKLLTH------------------------------- MATCH CONSENSUS ???????????????????W??R?????????????????????????????????????

B8JL72_DANRE B8JL72_DANRE ------------------------------------------------------------ Q4RTB1_TETNG Q4RTB1_TETNG --DYWSESDQDDVDGSMTLKQEGPPSLCDTYHRTPSVNSSSPFPEPKHGRHFSSESTHSH Q4S8W9_TETNG Q4S8W9_TETNG MAEYWSESDHEDMEMTSVSKQDSPPPPYDTYPRASSV---SPYLEPKRGHLSSSDTFQSR CNKR2_RAT CNKR2_RAT --DYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQ Q3URG0_MOUSE Q3URG0_MOUSE ------------------------------------------------------------ A2AI77_MOUSE A2AI77_MOUSE --DYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQ CNKR2_MOUSE CNKR2_MOUSE --DYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQ A2AI78_MOUSE A2AI78_MOUSE --DYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQ B3KPN2_HUMAN B3KPN2_HUMAN --DYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQ Q5R7V6_PONAB Q5R7V6_PONAB --DYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQ B7ZLJ1_HUMAN B7ZLJ1_HUMAN --DYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQ B4DGR4_HUMAN B4DGR4_HUMAN --DYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQ CNKR2_HUMAN CNKR2_HUMAN --DYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQ Q5JPN0_HUMAN Q5JPN0_HUMAN --DYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQ A4IJ08_XENTR A4IJ08_XENTR ------------------------------------------------------------ Q6GQI9_XENLA Q6GQI9_XENLA -INYWSESDQEEVDTPSTPKQDSPPPPYDTYPRPASMSCASPFVEPKH-RLSSTETSQSQ B5DE81_XENTR B5DE81_XENTR ------------------------------------------------------------ CNKR3_HUMAN CNKR3_HUMAN ------------------------------------------------------------ CNKR3_MOUSE CNKR3_MOUSE ------------------------------------------------------------ CNKR3_RAT CNKR3_RAT ------------------------------------------------------------ Q4RP02_TETNG Q4RP02_TETNG ------------------------------------------------------------ A8WG10_DANRE A8WG10_DANRE ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

B8JL72_DANRE B8JL72_DANRE ------------------------------------------------------------ Q4RTB1_TETNG Q4RTB1_TETNG SSAEDQRGDSIGMGTGTGSTSTHSSGCRSSHRERRSWQDLIETPLTSAGLHFLQTAPGES Q4S8W9_TETNG Q4S8W9_TETNG SSHEEFHSEPLD---TSSGSNNGISPGQKMSSHRNSWQDQMETNM---RLQYLQTFSGEE CNKR2_RAT CNKR2_RAT SSHEEFRQEVTG---SSA-----VSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLED Q3URG0_MOUSE Q3URG0_MOUSE ------------------------------------------------------------ A2AI77_MOUSE A2AI77_MOUSE SSHEEFRQEVTG---SSA-----VSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLED CNKR2_MOUSE CNKR2_MOUSE SSHEEFRQEVTG---SSA-----VSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLED A2AI78_MOUSE A2AI78_MOUSE SSHEEFRQEVTG---SSA-----VSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLED B3KPN2_HUMAN B3KPN2_HUMAN SSHEEFRQEVTG---SSA-----VSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLED Q5R7V6_PONAB Q5R7V6_PONAB SSHEEFRQEVTG---SSA-----VSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLED B7ZLJ1_HUMAN B7ZLJ1_HUMAN SSHEEFRQEVTG---SSA-----VSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLED B4DGR4_HUMAN B4DGR4_HUMAN SSHEEFRQEVTG---SSA-----VSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLED CNKR2_HUMAN CNKR2_HUMAN SSHEEFRQEVTG---SSA-----VSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLED Q5JPN0_HUMAN Q5JPN0_HUMAN SSHEEFRQEVTG---SSA-----VSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLED A4IJ08_XENTR A4IJ08_XENTR ------------------------------------------------GLNRIKAA---- Q6GQI9_XENLA Q6GQI9_XENLA SSHEEFRQEAAG---STT-----DSPVRKTASQRRSWQDLIETPLTSSGLHYLQTLPLED B5DE81_XENTR B5DE81_XENTR ------------------------------------------------------------ CNKR3_HUMAN CNKR3_HUMAN ------------------------------------------------------------ CNKR3_MOUSE CNKR3_MOUSE ------------------------------------------------------------ CNKR3_RAT CNKR3_RAT ------------------------------------------------------------ Q4RP02_TETNG Q4RP02_TETNG ------------------------------------------------------------ A8WG10_DANRE A8WG10_DANRE ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

B8JL72_DANRE B8JL72_DANRE ------------------------------------------------------------ Q4RTB1_TETNG Q4RTB1_TETNG DYGGLMGTMAGDMGLYGGLGRQGMSPERRRQATLPVRRHHAAERDRERDGPFPLERGPYS Q4S8W9_TETNG Q4S8W9_TETNG A--------------LVIDNSDQLAMEYRRQSTLPPPRSLL----QEHYRALPLP--L-R CNKR2_RAT CNKR2_RAT S--------------VFSDSA-AISPEHRRQSTLPTQKCHL----QDHYGPYPLAESE-R Q3URG0_MOUSE Q3URG0_MOUSE ------------------------------------------------------------ A2AI77_MOUSE A2AI77_MOUSE S--------------VFSDSA-AISPEHRRQSTLPTQKCHL----QDHYGPYPLAESE-R CNKR2_MOUSE CNKR2_MOUSE S--------------VFSDSA-AISPEHRRQSTLPTQKCHL----QDHYGPYPLAESE-R A2AI78_MOUSE A2AI78_MOUSE S--------------VFSDSA-AISPEHRRQSTLPTQKCHL----QDHYGPYPLAESE-R B3KPN2_HUMAN B3KPN2_HUMAN S--------------VFSDSA-AISPEHRRQSTLPTQKCHL----QDHYGPYPLAESE-R Q5R7V6_PONAB Q5R7V6_PONAB S--------------VFSDSA-AISPEHRRQSTLPTQKCHL----QDHYGPYPLAESE-R B7ZLJ1_HUMAN B7ZLJ1_HUMAN S--------------VFSDSA-AISPEHRRQSTLPTQKCHL----QDHYGPYPLAESE-R B4DGR4_HUMAN B4DGR4_HUMAN S--------------VFSDSA-AISPEHRRQSTLPTQKCHL----QDHYGPYPLAESE-R CNKR2_HUMAN CNKR2_HUMAN S--------------VFSDSA-AISPEHRRQSTLPTQKCHL----QDHYGPYPLAESE-R Q5JPN0_HUMAN Q5JPN0_HUMAN S--------------VFSDSA-AISPEHRRQSTLPTQKCHL----QDHYGPYPLAESE-R A4IJ08_XENTR A4IJ08_XENTR ------------------------------------------------------------ Q6GQI9_XENLA Q6GQI9_XENLA S--------------VFLEPA-VVSPDHRRQSTLPAQKCHL----QDHYGPFSLAEGK-Q B5DE81_XENTR B5DE81_XENTR ------------------------------------------------------------ CNKR3_HUMAN CNKR3_HUMAN ------------------------------------------------------------ CNKR3_MOUSE CNKR3_MOUSE ------------------------------------------------------------ CNKR3_RAT CNKR3_RAT ------------------------------------------------------------ Q4RP02_TETNG Q4RP02_TETNG ------------------------------------------------------------ A8WG10_DANRE A8WG10_DANRE ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

B8JL72_DANRE B8JL72_DANRE ------------------------------------------------------------ Q4RTB1_TETNG Q4RTB1_TETNG YSHTHRHSHKQRSQSLPRNRDPMPGRLLHTSIHMEERSEDEEAEDQAADLLPGEDVIDLP Q4S8W9_TETNG Q4S8W9_TETNG ASMDSEAGGKPRSFTLPRD-----SGL-HAILAATAAASEQREPQHYRLERPGDS----- CNKR2_RAT CNKR2_RAT MQVLNGNGGKPRSFTLPRD-----SGFNHCCLNAPVSACDPQDDIQPPEVEEEEE----- Q3URG0_MOUSE Q3URG0_MOUSE ------------------------------------------------------------ A2AI77_MOUSE A2AI77_MOUSE MQVLNGNGGKPRSFTLPRD-----SGFNHCCLNTPVSACDPQDDIQPPEVEEEEE----- CNKR2_MOUSE CNKR2_MOUSE MQVLNGNGGKPRSFTLPRD-----SGFNHCCLNTPVSACDPQDDIQPPEVEEEEE----- A2AI78_MOUSE A2AI78_MOUSE MQVLNGNGGKPRSFTLPRD-----SGFNHCCLNTPVSACDPQDDIQPPEVEEEEE----- B3KPN2_HUMAN B3KPN2_HUMAN MQVLNGNGGKPRSFTLPRD-----SGFNHCCLNAPVSACDPQDDVQPPEVEEEEE----- Q5R7V6_PONAB Q5R7V6_PONAB MQVLNGNGGKPRSFTLPRD-----SGFNHCCLNAPVSACDPQDDAQPPEVEEEEE----- B7ZLJ1_HUMAN B7ZLJ1_HUMAN MQVLNGNGGKPRSFTLPRD-----SGFNHCCLNAPVSACDPQDDVQPPEVEEEEE----- B4DGR4_HUMAN B4DGR4_HUMAN MQVLNGNGGKPRSFTLPRD-----SGFNHCCLNAPVSACDPQDDVQPPEVEEEEE----- CNKR2_HUMAN CNKR2_HUMAN MQVLNGNGGKPRSFTLPRD-----SGFNHCCLNAPVSACDPQDDVQPPEVEEEEE----- Q5JPN0_HUMAN Q5JPN0_HUMAN MQVLNGNGGKPRSFTLPRD-----SGFNHCCLNAPVSACDPQDDVQPPEVEEEEE----- A4IJ08_XENTR A4IJ08_XENTR ------------------------------------------------------------ Q6GQI9_XENLA Q6GQI9_XENLA SQAQSGSGAKPRSFTLPRD-----GGLSHCAPLSPVSILEPLESSPKRETRGEAK----- B5DE81_XENTR B5DE81_XENTR ------------------------------------------------------------ CNKR3_HUMAN CNKR3_HUMAN ------------------------------------------------------------ CNKR3_MOUSE CNKR3_MOUSE ------------------------------------------------------------ CNKR3_RAT CNKR3_RAT ------------------------------------------------------------ Q4RP02_TETNG Q4RP02_TETNG ------------------------------------------------------------ A8WG10_DANRE A8WG10_DANRE ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

B8JL72_DANRE B8JL72_DANRE ------------------------------------------------------------ Q4RTB1_TETNG Q4RTB1_TETNG LSDPLLGVSDLRELRVESRERRISDGRERRVSESCELEMSDGLEQLYRALEQANLTALGD Q4S8W9_TETNG Q4S8W9_TETNG ---------------AARRDCRLQADSLGD---------------LYRALEQTSLASSAD CNKR2_RAT CNKR2_RAT ---------------EEEE--EAAGENIGEKNENREEKLGDSLQDLYRALEEASLSPLGE Q3URG0_MOUSE Q3URG0_MOUSE ------------------------------------------------------------ A2AI77_MOUSE A2AI77_MOUSE ---------------EEEE--EAAGENVGEKNENREEKLGDSLQDLYRALEEASLSPLGE CNKR2_MOUSE CNKR2_MOUSE ---------------EEEE--EAAGENVGEKNENREEKLGDSLQDLYRALEEASLSPLGE A2AI78_MOUSE A2AI78_MOUSE ---------------EEEE--EAAGENVGEKS---------------------------- B3KPN2_HUMAN B3KPN2_HUMAN ---------------EEEEEGEAAGENIGEKS---------------------------- Q5R7V6_PONAB Q5R7V6_PONAB ---------------EEEEEGEAAGENIGEKS---------------------------- B7ZLJ1_HUMAN B7ZLJ1_HUMAN ---------------EEEEEGEAAGENIGEKSESREEKLGDSLQDLYRALEQASLSPLGE B4DGR4_HUMAN B4DGR4_HUMAN ---------------EEEEEGEAAGENIGEKS---------------------------- CNKR2_HUMAN CNKR2_HUMAN ---------------EEEEEGEAAGENIGEKSESREEKLGDSLQDLYRALEQASLSPLGE Q5JPN0_HUMAN Q5JPN0_HUMAN ---------------EEEEEGEAAGENIGEKS---------------------------- A4IJ08_XENTR A4IJ08_XENTR ------------------------------------------------------------ Q6GQI9_XENLA Q6GQI9_XENLA ---------------SDQP------GKAEDATETVDEKPADSLQDLYRALEQASLSPLGD B5DE81_XENTR B5DE81_XENTR ------------------------------------------------------------ CNKR3_HUMAN CNKR3_HUMAN ------------------------------------------------------------ CNKR3_MOUSE CNKR3_MOUSE ------------------------------------------------------------ CNKR3_RAT CNKR3_RAT ------------------------------------------------------------ Q4RP02_TETNG Q4RP02_TETNG ------------------------------------------------------------ A8WG10_DANRE A8WG10_DANRE ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

B8JL72_DANRE B8JL72_DANRE ------------------------------------------------------------ Q4RTB1_TETNG Q4RTB1_TETNG PKPCSRQELRRCFTQRARDPLLNDRLHRVRVLRSTLKAKESELAVICALLEDPGLCSQTF Q4S8W9_TETNG Q4S8W9_TETNG HRSTSRLEYKRSFVRRVNDPLLNDKLHRLRILNSSLK----------------------- CNKR2_RAT CNKR2_RAT HRISTKIEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEF Q3URG0_MOUSE Q3URG0_MOUSE ------------------------------------------------------------ A2AI77_MOUSE A2AI77_MOUSE HRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEF CNKR2_MOUSE CNKR2_MOUSE HRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEF A2AI78_MOUSE A2AI78_MOUSE ------------------------------------------------------------ B3KPN2_HUMAN B3KPN2_HUMAN ------------------------------------------------------------ Q5R7V6_PONAB Q5R7V6_PONAB ------------------------------------------------------------ B7ZLJ1_HUMAN B7ZLJ1_HUMAN HRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEF B4DGR4_HUMAN B4DGR4_HUMAN ------------------------------------------------------------ CNKR2_HUMAN CNKR2_HUMAN HRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEF Q5JPN0_HUMAN Q5JPN0_HUMAN ------------------------------------------------------------ A4IJ08_XENTR A4IJ08_XENTR ------------------------------------------------------------ Q6GQI9_XENLA Q6GQI9_XENLA RRLSTKVEYKKSFIKRSSDPVVNDKLHRLRILKSTLKAKEGEVAIIDKLLEKQEFTSKDF B5DE81_XENTR B5DE81_XENTR ------------------------------------------------------------ CNKR3_HUMAN CNKR3_HUMAN ------------------------------------------------------------ CNKR3_MOUSE CNKR3_MOUSE ------------------------------------------------------------ CNKR3_RAT CNKR3_RAT ------------------------------------------------------------ Q4RP02_TETNG Q4RP02_TETNG ------------------------------------------------------------ A8WG10_DANRE A8WG10_DANRE ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

B8JL72_DANRE B8JL72_DANRE ------------------------------------------------ Q4RTB1_TETNG Q4RTB1_TETNG REWKQWHSELYSDICQLSPGTNGQDDLSPLGAPL--MTHTHSFIETHV Q4S8W9_TETNG Q4S8W9_TETNG ------------------------------------------------ CNKR2_RAT CNKR2_RAT QQWKQMYLDLFLDICQNTTSNDPLSISSEVDVITSSLTHTHSYIETHV Q3URG0_MOUSE Q3URG0_MOUSE ------------------------------------------------ A2AI77_MOUSE A2AI77_MOUSE QQWKQMYLDLFLDICQSTTSNDPLSISSEVDVLTSSLTHTHSYIETHV CNKR2_MOUSE CNKR2_MOUSE QQWKQMYLDLFLDICQSTTSNDPLSISSEVDVLTSSLTHTHSYIETHV A2AI78_MOUSE A2AI78_MOUSE ------------------------------------------------ B3KPN2_HUMAN B3KPN2_HUMAN ------------------------------------------------ Q5R7V6_PONAB Q5R7V6_PONAB ------------------------------------------------ B7ZLJ1_HUMAN B7ZLJ1_HUMAN QQWKQMYLDLFLDICQNTTSNDPLSISSEVDVITSSLAHTHSYIETHV B4DGR4_HUMAN B4DGR4_HUMAN ------------------------------------------------ CNKR2_HUMAN CNKR2_HUMAN QQWKQMYLDLFLDICQNTTSNDPLSISSEVDVITSSLAHTHSYIETHV Q5JPN0_HUMAN Q5JPN0_HUMAN ------------------------------------------------ A4IJ08_XENTR A4IJ08_XENTR ------------------------------------------------ Q6GQI9_XENLA Q6GQI9_XENLA QEWKSSYLELFLDICQKSNSKDVESVSSEVDALIQSLAHMHSYIETHV B5DE81_XENTR B5DE81_XENTR ------------------------------------------------ CNKR3_HUMAN CNKR3_HUMAN ------------------------------------------------ CNKR3_MOUSE CNKR3_MOUSE ------------------------------------------------ CNKR3_RAT CNKR3_RAT ------------------------------------------------ Q4RP02_TETNG Q4RP02_TETNG ------------------------------------------------ A8WG10_DANRE A8WG10_DANRE ------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????


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