Alignment of the gene Family HBG051083 of HOVERGEN

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Threshold: 50% 80% 100%
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Isoforms are ON
Q4RTF5_TETNG Q4RTF5_TETNG ------------------------------------------------------------ Q4RE87_TETNG Q4RE87_TETNG ------------------------------------------AADGAGGVSAEQNHLTVP Q5ZIU5_CHICK Q5ZIU5_CHICK --------------------------------------------------------MGLP Q3UUZ1_MOUSE Q3UUZ1_MOUSE --------------------------------------------------------MTLP Q3UT06_MOUSE Q3UT06_MOUSE --------------------------------------------------------MTLP Q3UZA6_MOUSE Q3UZA6_MOUSE --------------------------------------------------------MTLP B1B072_MOUSE B1B072_MOUSE --------------------------------------------------------MTLP ENOX2_MOUSE ENOX2_MOUSE --------------------------------------------------------MTLP B1B074_MOUSE B1B074_MOUSE --------------------------------------------------------MTLP A4QPE1_HUMAN A4QPE1_HUMAN PFDPANNNEPLQFGSASGPLVTEGLIENGGESSKKRKRTNTPSADNSRTLNVDSTAMTLP A8K197_HUMAN A8K197_HUMAN ---------------------------MQRDFRWLWVYEIGYAADNSRTLNVDSTAMTLP ENOX2_HUMAN ENOX2_HUMAN ---------------------------MQRDFRWLWVYEIGYAADNSRTLNVDSTAMTLP B1AKF7_HUMAN B1AKF7_HUMAN --------------------------------------------------------MTLP Q32ND0_HUMAN Q32ND0_HUMAN --------------------------------------------------------MTLP B0S4Z9_DANRE B0S4Z9_DANRE ---------------------------------------MASAADGIGSLGTEQSHINVP A9JS36_XENLA A9JS36_XENLA ------------------------------------------------------------ B7ZR01_XENLA B7ZR01_XENLA ------------------------------------------------------------ B7ZQZ9_XENLA B7ZQZ9_XENLA ------------------------------------------------------------ Q95K71_MACFA Q95K71_MACFA ------------------------------------------------------------ ENOX1_HUMAN ENOX1_HUMAN -------------------MVDAGGVENITQLPQELPQMMAAAADGLGSIAIDTTQLNMS ENOX1_MOUSE ENOX1_MOUSE -------------------MVDAAGFESVAQCPRELHQMMAAAADGLGSIALDTTQLNMS MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4RTF5_TETNG Q4RTF5_TETNG ---------------------------------------------------------MVP Q4RE87_TETNG Q4RE87_TETNG VGEHGAWAAAMNHL-VLPVGVGGQQLLPDSLCLQRFQPSLGLLT---PVSPMMAGISLAP Q5ZIU5_CHICK Q5ZIU5_CHICK MSDPTAWATAMNNLGMAPMGMTGQPLLPD------FDPALGMMTGIPPINPMMPGLGIVP Q3UUZ1_MOUSE Q3UUZ1_MOUSE VSDPAAWATAMNNLGMAPLGIAGQPILPD------FDPALGMMTGIPPITPMMPGLGIVP Q3UT06_MOUSE Q3UT06_MOUSE VSDPAAWATAMNNLGMAPLGIAGQPILPD------FDPALGMMTGIPPITPMMPGLGIVP Q3UZA6_MOUSE Q3UZA6_MOUSE VSDPAAWATAMNNLGMAPLGIAGQPILPD------FDPALGMMTGIPPITPMMPGLGIVP B1B072_MOUSE B1B072_MOUSE VSDPAAWATAMNNLGMAPLGIAGQPILPD------FDPALGMMTGIPPITPMMPGLGIVP ENOX2_MOUSE ENOX2_MOUSE VSDPAAWATAMNNLGMAPLGIAGQPILPD------FDPALGMMTGIPPITPMMPGLGIVP B1B074_MOUSE B1B074_MOUSE VSDPAAWATAMNNLGMAPLGIAGQPILPD------FDPALGMMTGIPPITPMMPGLGIVP A4QPE1_HUMAN A4QPE1_HUMAN MSDPTAWATAMNNLGMAPLGIAGQPILPD------FDPALGMMTGIPPITPMMPGLGIVP A8K197_HUMAN A8K197_HUMAN MSDPTAWATAMNNLGMAPLGIAGQPILPD------FDPALGMMTGIPPITPMMPGLGIVP ENOX2_HUMAN ENOX2_HUMAN MSDPTAWATAMNNLGMAPLGIAGQPILPD------FDPALGMMTGIPPITPMMPGLGIVP B1AKF7_HUMAN B1AKF7_HUMAN MSDPTAWATAMNNLGMAPLGIAGQPILPD------FDPALGMMTGIPPITPMMPGLGIVP Q32ND0_HUMAN Q32ND0_HUMAN MSDPTAWATAMNNLGMAPLGIAGQPILPD------FDPALGMMTGIPPITPMMPGLGIVP B0S4Z9_DANRE B0S4Z9_DANRE VADPGAWATAMNNLGIVPMGLTGQQLVSDSICIQGFDPNIGIIT---PINPMMAGISLVP A9JS36_XENLA A9JS36_XENLA -------------------------MFPDSICVPGFDPSLSMMTGITQINPMMAGMGLLP B7ZR01_XENLA B7ZR01_XENLA -------------------------MFPDSICVPGFDPSLSMMTGITQINPMMAGMGLLP B7ZQZ9_XENLA B7ZQZ9_XENLA -------------------------MFPDSICVPGFDPSLSMMTGITQINPMMAGMGLLP Q95K71_MACFA Q95K71_MACFA ------------------------------------------------------------ ENOX1_HUMAN ENOX1_HUMAN VTDPTAWATAMNNLGMVPVGLPGQQLVSDSICVPGFDPSLNMMTGITPINPMIPGLGLVP ENOX1_MOUSE ENOX1_MOUSE VTDPTAWATAMNNLGMVPVGLPGQQLVSDSICVPGFDPGLNMMTGITPINPMIPGLGLVP MATCH CONSENSUS ????????????????????????????D??????FDP?L?MMTGI??I?PMM?G?G??P

Q4RTF5_TETNG Q4RTF5_TETNG A-PVSQELSLIKEIIHCKSCTLFPPNPNLPPPATRDRPPGCKTVFVGGLPENATEQLIME Q4RE87_TETNG Q4RE87_TETNG P-------PPVKEIIHCSSCTLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEELIRE Q5ZIU5_CHICK Q5ZIU5_CHICK P-PIPPDMPAVKEIIHCKSCTLFPPNPHLPPPATRERPPGCKTVFVGGLLENGTEQIIME Q3UUZ1_MOUSE Q3UUZ1_MOUSE P-PIPPDMPVAKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQIIVE Q3UT06_MOUSE Q3UT06_MOUSE P-PIPPDMPVAKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQIIVE Q3UZA6_MOUSE Q3UZA6_MOUSE P-PIPPDMPVAKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQIIVE B1B072_MOUSE B1B072_MOUSE P-PIPPDMPVAKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQIIVE ENOX2_MOUSE ENOX2_MOUSE P-PIPPDMPVAKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQIIVE B1B074_MOUSE B1B074_MOUSE P-PIPPDMPVAKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQIIVE A4QPE1_HUMAN A4QPE1_HUMAN P-PIPPDMPVVKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQIIVE A8K197_HUMAN A8K197_HUMAN P-PIPPDMPVVKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQIIVE ENOX2_HUMAN ENOX2_HUMAN P-PIPPDMPVVKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQIIVE B1AKF7_HUMAN B1AKF7_HUMAN P-PIPPDMPVVKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQIIVE Q32ND0_HUMAN Q32ND0_HUMAN P-PIPPDMPVVKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQIIVE B0S4Z9_DANRE B0S4Z9_DANRE PHPVAAELPVIKEIIHCKSCTLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIKE A9JS36_XENLA A9JS36_XENLA P--LPTQLPIVKEIIHCKSCTLFPPNPNLPPPSTRERPPGCKTVFVGGLPENATDEIIQE B7ZR01_XENLA B7ZR01_XENLA P--LPTQLPIVKEIIHCKSCTLFPPNPNLPPPSTRERPPGCKTVFVGGLPENATDEIIQE B7ZQZ9_XENLA B7ZQZ9_XENLA P--LPTQLPIVKEIIHCKSCTLFPPNPNLPPPSTRERPPGCKTVFVGGLPENATDEIIQE Q95K71_MACFA Q95K71_MACFA ------------------------------MQAEDACPGGAAPAQAGGGPAPA------- ENOX1_HUMAN ENOX1_HUMAN P-PPPTEVAVVKEIIHCKSCTLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIQE ENOX1_MOUSE ENOX1_MOUSE P-PPPTEVAVVKEIIHCKSCTLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIQE MATCH : * *. .. .** . CONSENSUS P???P???P??KEIIHCKSCTLFP?NPNLPPP?TRERPPGCKTVFVGGLPEN?TE?II?E

Q4RTF5_TETNG Q4RTF5_TETNG VFGQCGDITAIRKSKKNFCHIRFAEESTVDKAVFVSGYRIRLGSSTDKKDTGRLHVDFAQ Q4RE87_TETNG Q4RE87_TETNG VFERCGEIAAIRKSKKNFCHIRFSEEPTVDKALFLSGYRMRIGSSTDKKDTGKIHVDFAQ Q5ZIU5_CHICK Q5ZIU5_CHICK VFEQCGEVIAIRESKKNFCHIRFAEEFMVDKALYLSGYRIRLGSSTDKKDTGRLHVDFAQ Q3UUZ1_MOUSE Q3UUZ1_MOUSE VFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRLHVDFAQ Q3UT06_MOUSE Q3UT06_MOUSE VFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRLHVDFAQ Q3UZA6_MOUSE Q3UZA6_MOUSE VFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRLHVDFAQ B1B072_MOUSE B1B072_MOUSE VFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRLHVDFAQ ENOX2_MOUSE ENOX2_MOUSE VFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRLHVDFAQ B1B074_MOUSE B1B074_MOUSE VFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRLHVDFAQ A4QPE1_HUMAN A4QPE1_HUMAN VFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRLHVDFAQ A8K197_HUMAN A8K197_HUMAN VFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRLHVDFAQ ENOX2_HUMAN ENOX2_HUMAN VFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRLHVDFAQ B1AKF7_HUMAN B1AKF7_HUMAN VFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRLHVDFAQ Q32ND0_HUMAN Q32ND0_HUMAN VFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRLHVDFAQ B0S4Z9_DANRE B0S4Z9_DANRE VFDQCGEIIAIRKSKKNFCHIRFIEEFMVDKALYLSGYRMRIGSSTDKKDSGRIHVDFAQ A9JS36_XENLA A9JS36_XENLA LFEQCGDITAIRKSKKNFCHIRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDFAQ B7ZR01_XENLA B7ZR01_XENLA LFEQCGDITAIRKSKKNFCHIRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDFAQ B7ZQZ9_XENLA B7ZQZ9_XENLA LFEQCGDITAIRKSKKNFCHIRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDFAQ Q95K71_MACFA Q95K71_MACFA ------------------------------------------------------------ ENOX1_HUMAN ENOX1_HUMAN VFEQCGDITAIRKSKKNFCHIRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDFAQ ENOX1_MOUSE ENOX1_MOUSE VFEQCGDITAIRKSKKNFCHIRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDFAQ MATCH CONSENSUS VFEQCG?I?AIRKSKKNFCHIRFAEE?MVDKA?YLSGYR?RLGSSTDKKD?GRLHVDFAQ

Q4RTF5_TETNG Q4RTF5_TETNG ARDDLYEWECRQRMLAREERHRRKMEEDRLRPPSPPPIVHYSEHECSQLGEKIKDGARFV Q4RE87_TETNG Q4RE87_TETNG ARDDLYEWECRQRLLARAERHRRRGQEGRPGPPSPPPVAHYSEHEAALLADRLRDDQQFS Q5ZIU5_CHICK Q5ZIU5_CHICK ARDDLYEWECKQRMLAREERHRRRLEEERFHPPSPPPVVHYSDHECSIVAEKLKDDTKFS Q3UUZ1_MOUSE Q3UUZ1_MOUSE ARDDLYEWECKQRMLAREERHRRRMEEERMRPPSPPPVVHYSDHECSIVAEKLKDDSKFS Q3UT06_MOUSE Q3UT06_MOUSE ARDDLYEWECKQRMLAREERHRRRMEEERMRPPSPPPVVHYSDHECSIVAEKLKDDSKFS Q3UZA6_MOUSE Q3UZA6_MOUSE ARDDLYEWECKQRMLAREERHRRRMEEERMRPPSPPPVVHYSDHECSIVAEKLKDDSKFS B1B072_MOUSE B1B072_MOUSE ARDDLYEWECKQRMLAREERHRRRMEEERMRPPSPPPVVHYSDHECSIVAEKLKDDSKFS ENOX2_MOUSE ENOX2_MOUSE ARDDLYEWECKQRMLAREERHRRRMEEERMRPPSPPPVVHYSDHECSIVAEKLKDDSKFS B1B074_MOUSE B1B074_MOUSE ARDDLYEWECKQRMLAREERHRRRMEEERMRPPSPPPVVHYSDHECSIVAEKLKDDSKFS A4QPE1_HUMAN A4QPE1_HUMAN ARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFS A8K197_HUMAN A8K197_HUMAN ARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFS ENOX2_HUMAN ENOX2_HUMAN ARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFS B1AKF7_HUMAN B1AKF7_HUMAN ARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFS Q32ND0_HUMAN Q32ND0_HUMAN ARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFS B0S4Z9_DANRE B0S4Z9_DANRE ARDDLYEWECKQRLLAREERHRRKIHEERLRPPSPPPIMHYSEHEATLLAEKLKDDNKFS A9JS36_XENLA A9JS36_XENLA ARDDFYEWECKQRMLAREERHRRKLEVDKLRPPSPPAIMHYSEHEAAMLAEKLKDDTKFC B7ZR01_XENLA B7ZR01_XENLA ARDDFYEWECKQRMLAREERHRRKLEVDKLRPPSPPAIMHYSEHEAAMLAEKLKDDTKFC B7ZQZ9_XENLA B7ZQZ9_XENLA ARDDFYEWECKQRMLAREERHRRKLEVDKLRPPSPPAIMHYSEHEAAMLAEKLKDDTKFC Q95K71_MACFA Q95K71_MACFA --------------------------------PSPPAIMHYSEHEAALLAEKLKDDSKFS ENOX1_HUMAN ENOX1_HUMAN ARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFS ENOX1_MOUSE ENOX1_MOUSE ARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLADKLKDDSKFS MATCH ****.: ***:**.: :.::::*. :* CONSENSUS ARDD?YEWECKQRMLAREERHRR??EE?R?RPPSPP???HYS?HE????AEKLKDD?KFS

Q4RTF5_TETNG Q4RTF5_TETNG PPSTRYLCISLFSGAHGKNHPVFLSKAKEA-------FQNKAKHLFDLPTSAFLFSTLIS Q4RE87_TETNG Q4RE87_TETNG GAAGVLFAWIDRGEVNRRTSNHFYSMIQSANSHVRRLMVEKAQEEEEMERARDAYRSALL Q5ZIU5_CHICK Q5ZIU5_CHICK EAVQTLLTWIERGEVNRRTANNFYSMIQSANSHIRRLVNEKAAHEKEMEEAKEKFKLALS Q3UUZ1_MOUSE Q3UUZ1_MOUSE EAVQTLLTWIERGEVNRRSANHFYSMIQSANSHVRRLVNEKATHEKEMEEAKEKFKQALS Q3UT06_MOUSE Q3UT06_MOUSE EAVQTLLTWIERGEVNRRSANHFYSMIQSANSHVRRLVNEKATHEKEMEEAKEKFKQALS Q3UZA6_MOUSE Q3UZA6_MOUSE GAVQTLLTWIERGEVNRRSANHFYSMIQSANSHVRRLVNEKATHEKEMEEAKEKFKQALS B1B072_MOUSE B1B072_MOUSE EAVQTLLTWIERGEVNRRSANHFYSMIQSANSHVRRLVNEKATHEKEMEEAKEKFKQALS ENOX2_MOUSE ENOX2_MOUSE EAVQTLLTWIERGEVNRRSANHFYSMIQSANSHVRRLVNEKATHEKEMEEAKEKFKQALS B1B074_MOUSE B1B074_MOUSE EAVQTLLTWIERGEVNRRSANHFYSMIQSANSHVRRLVNEKATHEKEMEEAKEKFKQALS A4QPE1_HUMAN A4QPE1_HUMAN EAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALS A8K197_HUMAN A8K197_HUMAN EAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALS ENOX2_HUMAN ENOX2_HUMAN EAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALS B1AKF7_HUMAN B1AKF7_HUMAN EAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALS Q32ND0_HUMAN Q32ND0_HUMAN EAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALS B0S4Z9_DANRE B0S4Z9_DANRE EATAVLFTWIDRGEVNRRSANHFYSMIQSANSHVRRLMSEKAQHEEEMELAKEHFKNSLL A9JS36_XENLA A9JS36_XENLA EAITVLFTWIERGEVNRRSANQFYSMIQSANSHVRRLMNEKAADEEKMEDAKEIFKTALF B7ZR01_XENLA B7ZR01_XENLA EAITVLFTWIERGEVNRRSANQFYSMIQSANSHVRRLMNEKAADEEKMEDAKEIFKTALF B7ZQZ9_XENLA B7ZQZ9_XENLA EAITVLFTWIERGEVNRRSANQFYSMIQSANSHVRRLMNEKAADEEKMEDAKEIFKTALF Q95K71_MACFA Q95K71_MACFA EAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALT ENOX1_HUMAN ENOX1_HUMAN EAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALT ENOX1_MOUSE ENOX1_MOUSE EAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALT MATCH . : . .: :. * * :.* . :** . .: : : : CONSENSUS EA???L??WIERGEVNRRSAN?FYSMIQSANSHVRRL?NEKA?HE??ME?AKE?FK?AL?

Q4RTF5_TETNG Q4RTF5_TETNG KY--PSEPVVNVDNELFLPRAPEKSHSPVFVGLIPFFECVLQEIRNLHNEQLMGIRREEE Q4RE87_TETNG Q4RE87_TETNG AVLTQ-------CKNTSQQKAWDH-FSKAQRKNIDMWRKQCEELRNAYSEEVTGIRREEE Q5ZIU5_CHICK Q5ZIU5_CHICK GILVQFEQIVAVYHSASKQKAWDH-FTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEE Q3UUZ1_MOUSE Q3UUZ1_MOUSE GILIQFEQIVAVYHSASKQKAWDH-FTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEE Q3UT06_MOUSE Q3UT06_MOUSE GILIQFEQIVAVYHSASKQKAWDH-FTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEE Q3UZA6_MOUSE Q3UZA6_MOUSE GILIQFEQIVAVYHSASKQKAWDH-FTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEE B1B072_MOUSE B1B072_MOUSE GILIQFEQIVAVYHSASKQKAWDH-FTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEE ENOX2_MOUSE ENOX2_MOUSE GILIQFEQIVAVYHSASKQKAWDH-FTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEE B1B074_MOUSE B1B074_MOUSE GILIQFEQIVAVYHSASKQKAWDH-FTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEE A4QPE1_HUMAN A4QPE1_HUMAN GILIQFEQIVAVYHSASKQKAWDH-FTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEE A8K197_HUMAN A8K197_HUMAN GILIQFEQIVAVYHSASKQKAWDH-FTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEE ENOX2_HUMAN ENOX2_HUMAN GILIQFEQIVAVYHSASKQKAWDH-FTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEE B1AKF7_HUMAN B1AKF7_HUMAN GILIQFEQIVAVYHSASKQKAWDH-FTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEE Q32ND0_HUMAN Q32ND0_HUMAN GILIQFEQIVAVYHSASKQKAWDH-FTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEE B0S4Z9_DANRE B0S4Z9_DANRE AILTQFEQITAVFTAATRQKAWDH-FSKAQRKNIDIWRKQCEELRNAHSEEIMGIRREEE A9JS36_XENLA A9JS36_XENLA GILTQFEQIVAVFNASTRQKAWDH-FSKAQRKNIDIWRKHCEDLRNAQSEQLMGIRREEE B7ZR01_XENLA B7ZR01_XENLA GILTQFEQIVAVFNASTRQKAWDH-FSKAQRKNIDIWRKHCEDLRNAQSEQLMGIRREEE B7ZQZ9_XENLA B7ZQZ9_XENLA GILTQFEQIVAVFNASTRQKAWDH-FSKAQRKNIDIWRKHCEDLRNAQSEQLMGIRREEE Q95K71_MACFA Q95K71_MACFA GILTQFEQIVAVFNASTRQKAWDH-FSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEE ENOX1_HUMAN ENOX1_HUMAN GILTQFEQIVAVFNASTRQKAWDH-FSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEE ENOX1_MOUSE ENOX1_MOUSE GILTQFEQIVAVFNASTRQKAWDH-FSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEE MATCH :* :: .: . * .: :::** .::: ******* CONSENSUS GIL?QFEQIVAV??????QKAWDH?F?KAQRKNI??W?K??EE?RN?????LMGIRREEE

Q4RTF5_TETNG Q4RTF5_TETNG MEMSDDDMED-TLDSKDSEDSGVL-QSEALKEENDSLRCQLDAYRNEVELLKQEQGKNQP Q4RE87_TETNG Q4RE87_TETNG MEMSEDDAEESPCKRTRTGGC-----EQTLREENDSLRWQLDSYKNEVEQLRNSQPDQ-- Q5ZIU5_CHICK Q5ZIU5_CHICK MEMSDEEIED-PSEMKETDESALVSQVEALKEENDSLRWQLDAYRNEVELLKQEHGKAS- Q3UUZ1_MOUSE Q3UUZ1_MOUSE MEMSDDEIEE-TTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKAH- Q3UT06_MOUSE Q3UT06_MOUSE MEMSDDEIEE-TTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKAH- Q3UZA6_MOUSE Q3UZA6_MOUSE MEMSDDEIEE-TTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKAH- B1B072_MOUSE B1B072_MOUSE MEMSDDEIEE-TTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKAH- ENOX2_MOUSE ENOX2_MOUSE MEMSDDEIEE-TTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKAH- B1B074_MOUSE B1B074_MOUSE MEMSDDEIEE-TTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKAH- A4QPE1_HUMAN A4QPE1_HUMAN MEMSDDEIEE-MTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVH- A8K197_HUMAN A8K197_HUMAN MEMSDDEIEE-MTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVH- ENOX2_HUMAN ENOX2_HUMAN MEMSDDEIEE-MTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVH- B1AKF7_HUMAN B1AKF7_HUMAN MEMSDDEIEE-MTETKETEES--------------------------------------- Q32ND0_HUMAN Q32ND0_HUMAN MEMSDDEIEE-MTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVH- B0S4Z9_DANRE B0S4Z9_DANRE MEMSDEDSDENPCKKIRLEDSVLSAQSCALREENDSLRWQLDAYRNEVELLKKEQGKMY- A9JS36_XENLA A9JS36_XENLA MEMSDDDSNDIPNKKARLDESALAAQAYALKEENDSLRWQLDAYRNEVDLLKQEKGHHG- B7ZR01_XENLA B7ZR01_XENLA MEMSDDDSNDIPNKKARLDESALTAQAYALKEENDSLRWQLDAYRNEVDLLKQEKGHHG- B7ZQZ9_XENLA B7ZQZ9_XENLA MEMSDDDSNDIPNKKARLDESALTAQAYALKEENDSLRWQLDAYRNEVDLLKQEKGHHG- Q95K71_MACFA Q95K71_MACFA MEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEEEQLF- ENOX1_HUMAN ENOX1_HUMAN MEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLF- ENOX1_MOUSE ENOX1_MOUSE MEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLF- MATCH ****::: : . . CONSENSUS MEMSDD?????????????ESAL??Q??ALKEENDSLRWQLDAYRNEVELLKQE??????

Q4RTF5_TETNG Q4RTF5_TETNG MRSEEDSTHSQQLSFLQQALQGMQKQLLKMREELKQREAELERSLDDKQQLKSQVQTLKE Q4RE87_TETNG Q4RE87_TETNG ---EQPLSPDVQIQLLQQSLHSMQQQVLSLQDKLRNKEADVEQVKEEHRCLEGQMTVLQA Q5ZIU5_CHICK Q5ZIU5_CHICK -R-DEDTTKEQQLKLLRQALQGMQQHLLKVQDEYKKREAELEKVKEDKLKIETLLETLKE Q3UUZ1_MOUSE Q3UUZ1_MOUSE -R-EDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELDRIKDDNLQVEQLLENFHE Q3UT06_MOUSE Q3UT06_MOUSE -R-EDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELDRIKDDNLQVEQLLENFHE Q3UZA6_MOUSE Q3UZA6_MOUSE -R-EDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELDRIKDDNLQVEQLLENFHE B1B072_MOUSE B1B072_MOUSE -R-EDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELDRIKDDNLQVEQLLENFHE ENOX2_MOUSE ENOX2_MOUSE -R-EDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELDRIKDDNLQVEQLLENFHE B1B074_MOUSE B1B074_MOUSE -R-EDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELDRIKDDNLQVEQLLENFHE A4QPE1_HUMAN A4QPE1_HUMAN -R-EDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKE A8K197_HUMAN A8K197_HUMAN -R-EDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKE ENOX2_HUMAN ENOX2_HUMAN -R-EDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKE B1AKF7_HUMAN B1AKF7_HUMAN ------------------------------------------------------------ Q32ND0_HUMAN Q32ND0_HUMAN -R-EDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKKKK---- B0S4Z9_DANRE B0S4Z9_DANRE -RTEEDHTHEQQLHFLQQTMQNMQQ----------------------------------- A9JS36_XENLA A9JS36_XENLA -RTEESVTKDQQLQFLQQTMQTMQQQLAAMQEELNNKKSELEKAKEEQTHAHALVRVLKE B7ZR01_XENLA B7ZR01_XENLA -RTEENVTKDQQLQFLQQTMQTMQQQLAAMQEELNNKKSELEKAKEEQTHAHALVRVLKE B7ZQZ9_XENLA B7ZQZ9_XENLA -RTEENVTKDQQLQFLQQTMQTMQQQLAAMQEELNNKKSELEKAKEEQTHAHALVRVLKE Q95K71_MACFA Q95K71_MACFA -RTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQE ENOX1_HUMAN ENOX1_HUMAN -RTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQE ENOX1_MOUSE ENOX1_MOUSE -RTEENLTKDQQLQFLQQTMQGMQQQLLAIQEELNNKKSELEQAKEEQSHTQALLKVLQE MATCH CONSENSUS ?R?E????K?QQL??LQQ??Q?MQQ?L???QEE???K??EL???K??????????????E

Q4RTF5_TETNG Q4RTF5_TETNG GLQNLK--------------NTHRLQVMPCSQEKERPPEKRL-QSPVQSEREAVLVGIIS Q4RE87_TETNG Q4RE87_TETNG KLLSTNVEAVEGSEPRL---QGIGGRVPCLYHSRERRAEAT-----VASEKEAVLLGIIS Q5ZIU5_CHICK Q5ZIU5_CHICK QQSVANEEDKERDVTDGQGNESSMPRVCACSQEKECPVEKTLSNSPVKSEREALLVGIIS Q3UUZ1_MOUSE Q3UUZ1_MOUSE KQ------------------ENCGSRLCASSQEGEQPLEKTAVSNPVKSEREALLVGIIS Q3UT06_MOUSE Q3UT06_MOUSE KQ------------------ENCGSRLCASSQEGEQPLEKTAVSNPVKSEREALVVGIIS Q3UZA6_MOUSE Q3UZA6_MOUSE KQ------------------ENCGSRLCASSQEGEQPLEKTAVSNPVKSEREALLVGIIS B1B072_MOUSE B1B072_MOUSE KQ------------------ENCGSRLCASSQEGEQPLEKTAVSNPVKSEREALLVGIIS ENOX2_MOUSE ENOX2_MOUSE KQ------------------ENCGSRLCASSQEGEQPLEKTAVSNPVKSEREALLVGIIS B1B074_MOUSE B1B074_MOUSE KQ------------------ENCGSRLCASSQEGEQPLEKTAVSNPVKSEREALLVGIIS A4QPE1_HUMAN A4QPE1_HUMAN K-------------------ESCASRLCASNQDSEYPLEKTMNSSPIKSEREALLVGIIS A8K197_HUMAN A8K197_HUMAN K-------------------ESCASRLCASNQDSEYPLEKTMNSSPIKSEREALLVGIIS ENOX2_HUMAN ENOX2_HUMAN K-------------------ESCASRLCASNQDSEYPLEKTMNSSPIKSEREALLVGIIS B1AKF7_HUMAN B1AKF7_HUMAN ------------------------------------------------------------ Q32ND0_HUMAN Q32ND0_HUMAN ------------------------------------------------------------ B0S4Z9_DANRE B0S4Z9_DANRE ------------------------------------------------------------ A9JS36_XENLA A9JS36_XENLA QLKSAKEVTDVTNQEYL-SKETSTVSVAVYNHDKEKDAEKQ--RQSLKSEKEALLIGITS B7ZR01_XENLA B7ZR01_XENLA QLKSAKEVTDVTNQEYL-SKETSTVSVAVYNHDKEKDAEKQ--RQSLKSEKEALLIGITS B7ZQZ9_XENLA B7ZQZ9_XENLA QLKSAKEVTDVTNQEYL-SKETSTVSVAVYNHDKEKDAEKQ--RQSLKSEKEALLIGITS Q95K71_MACFA Q95K71_MACFA QLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKR--SQGLKSEKEALLIGIIS ENOX1_HUMAN ENOX1_HUMAN QLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKR--SQGLKSEKEALLIGIIS ENOX1_MOUSE ENOX1_MOUSE QLKGTKDLVETNGHSHEDANEINVLTVALVNQDRENNTEKR--SQGLKSEKEALLIGIIS MATCH CONSENSUS ??????????????????????????????????E???EK????????SE?EA?L?GI?S

Q4RTF5_TETNG Q4RTF5_TETNG TFLHVHPFGASIEYICSYLQRLDTK----------------INPTEVEALLSRLPCTFRQ Q4RE87_TETNG Q4RE87_TETNG TFLHVHPFGANLEYLWSYIQRLDSQ----------------VSAADLERLMVRLPTMFRQ Q5ZIU5_CHICK Q5ZIU5_CHICK TFLHVHPFGASIEYICSYLQRLDSK----------------ICTTEVEVLMTRLQTTFKQ Q3UUZ1_MOUSE Q3UUZ1_MOUSE TFLHVHPFGASIEYICSYLNRLDNKASYQIPSKLTTSPLLPISTSDVESLMSRLQHTFRQ Q3UT06_MOUSE Q3UT06_MOUSE TFLHVHPFGASIEYICSYLNRLDNKASYQIPSKLTTSPLLPISTSDVESLMSRLQHTFRQ Q3UZA6_MOUSE Q3UZA6_MOUSE TFLHVHPFGASIEYICSYLNRLDNKASYQIPSKLTTSPLLPISTSDVESLMSRLQHTFRQ B1B072_MOUSE B1B072_MOUSE TFLHVHPFGASIEYICSYLNRLDNKASYQIPSKLTTSPLLPISTSDVESLMSRLQHTFRQ ENOX2_MOUSE ENOX2_MOUSE TFLHVHPFGASIEYICSYLNRLDNKASYQIPSKLTTSPLLPISTSDVESLMSRLQHTFRQ B1B074_MOUSE B1B074_MOUSE TFLHVHPFGASIEYICSYLNRLDNK----------------ISTSDVESLMSRLQHTFRQ A4QPE1_HUMAN A4QPE1_HUMAN TFLHVHPFGASIEYICSYLHRLDNK----------------ICTSDVECLMGRLQHTFKQ A8K197_HUMAN A8K197_HUMAN TFLHVHPFGASIEYICSYLHRLDNK----------------ICTSDVECLMGRLQHTFKQ ENOX2_HUMAN ENOX2_HUMAN TFLHVHPFGASIEYICSYLHRLDNK----------------ICTSDVECLMGRLQHTFKQ B1AKF7_HUMAN B1AKF7_HUMAN ------------------------------------------------------------ Q32ND0_HUMAN Q32ND0_HUMAN ------------------------------------------------------------ B0S4Z9_DANRE B0S4Z9_DANRE ------------------------------------------------------------ A9JS36_XENLA A9JS36_XENLA TFLNVHPFGANTEYLWSYLQQLDST----------------ISANEIETLLTKLPRMFKQ B7ZR01_XENLA B7ZR01_XENLA TFLNVHPFGVNTEYLWSYLQQLDST----------------ISANEIETLLTKLPRMFKQ B7ZQZ9_XENLA B7ZQZ9_XENLA TFLNVHPFGANTEYLWSYLQQLDST----------------ISANEIETLLTKLPRMFKQ Q95K71_MACFA Q95K71_MACFA TFLHVHPFGANIEYLWSYMQQLDSK----------------ISANEIEMLLMRLPRMFKQ ENOX1_HUMAN ENOX1_HUMAN TFLHVHPFGANIEYLWSYMQQLDSK----------------ISANEIEMLLMRLPRMFKQ ENOX1_MOUSE ENOX1_MOUSE TFLHVHPFGANIEYLWSYMQQLDSK----------------ISANEIEMLLMRLPRMFKQ MATCH CONSENSUS TFL?VHPFGA??EY??SY???LD??????????????????I?????E?L???L???F?Q

Q4RTF5_TETNG Q4RTF5_TETNG ELTGVGASLEKRWNFCGFQGIKST Q4RE87_TETNG Q4RE87_TETNG ELSGVGANLEKRWSFCGFDSL--- Q5ZIU5_CHICK Q5ZIU5_CHICK ELSGVGASLEKKWKFCGFDGLKMT Q3UUZ1_MOUSE Q3UUZ1_MOUSE EMTGVGASLEKRWKFCGFEGLRLT Q3UT06_MOUSE Q3UT06_MOUSE EMTGVGASLEKRWKFCGFEGLKLT Q3UZA6_MOUSE Q3UZA6_MOUSE EMTGVGASLEKRWKFCGFEGLKLT B1B072_MOUSE B1B072_MOUSE EMTGVGASLEKRWKFCGFEGLKLT ENOX2_MOUSE ENOX2_MOUSE EMTGVGASLEKRWKFCGFEGLKLT B1B074_MOUSE B1B074_MOUSE EMTGVGASLEKRWKFCGFEGLKLT A4QPE1_HUMAN A4QPE1_HUMAN EMTGVGASLEKRWKFCGFEGLKLT A8K197_HUMAN A8K197_HUMAN EMTGVGASLEKRWKFCGFEGLKLT ENOX2_HUMAN ENOX2_HUMAN EMTGVGASLEKRWKFCGFEGLKLT B1AKF7_HUMAN B1AKF7_HUMAN ------------------------ Q32ND0_HUMAN Q32ND0_HUMAN ------------------------ B0S4Z9_DANRE B0S4Z9_DANRE ------------------------ A9JS36_XENLA A9JS36_XENLA EFTGVGATLEKRWKFCAFEGIKTT B7ZR01_XENLA B7ZR01_XENLA EFTGVGATLEKRWKFCAFEGIKTT B7ZQZ9_XENLA B7ZQZ9_XENLA EFTGVGATLEKRWKFCAFEGIKTT Q95K71_MACFA Q95K71_MACFA EFTGVGATLEKRWKLCAFEGIKTT ENOX1_HUMAN ENOX1_HUMAN EFTGVGATLEKRWKLCAFEGIKTT ENOX1_MOUSE ENOX1_MOUSE EFTGVGATLEKRWKLCAFEGIKTT MATCH CONSENSUS E??GVGA?LEKRW??C?F?G???T


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