Alignment of the gene Family HBG051357 of HOVERGEN

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Threshold: 50% 80% 100%
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Isoforms are ON
Q5DTM7_MOUSE Q5DTM7_MOUSE PGSRARGAKPQIRSRPRPGKMERHRARAL--------------------GRDSKSSRRKG Q8K331_MOUSE Q8K331_MOUSE ------------------------------------------------------------ Q0VGT1_MOUSE Q0VGT1_MOUSE --------------------MERHRARAL--------------------GRDSKSSRRKG DIAP3_MOUSE DIAP3_MOUSE --------------------MERHRARAL--------------------GRDSKSSRRKG Q3TSX1_MOUSE Q3TSX1_MOUSE --------------------MERHRARAL--------------------GRDSKSSRRKG Q5PR81_MOUSE Q5PR81_MOUSE --------------------MERHRARAL--------------------GRDSKSSRRKG Q3UU77_MOUSE Q3UU77_MOUSE --------------------MERHRARAL--------------------GRDSKSSRRKG Q4R7E4_MACFA Q4R7E4_MACFA ------------------------------------------------------------ A6NG52_HUMAN A6NG52_HUMAN ------------------------------------------------------------ A8MYX0_HUMAN A8MYX0_HUMAN --------------------MERHQPRLHHPAQGSAAGTPYPSSASLRGCRESKMPRRKG B7ZB09_HUMAN B7ZB09_HUMAN --------------------MERHQPRLHHPAQGSAAGTPYPSSASLRGCRESKMPRRKG B4DPV3_HUMAN B4DPV3_HUMAN --------------------MERHQPRLHHPAQGSAAGTPYPSSASLRGCRESKMPRRKG DIAP3_HUMAN DIAP3_HUMAN --------------------MERHQPRLHHPAQGSAAGTPYPSSASLRGCRESKMPRRKG Q4R8N9_MACFA Q4R8N9_MACFA --------------------M--------------------------------------- Q7KZJ7_HUMAN Q7KZJ7_HUMAN ------------------------------------------------------------ A0RZB8_HUMAN A0RZB8_HUMAN --------------------MEPP-----------------------GGSLGPGRGTRDK Q6URC4_HUMAN Q6URC4_HUMAN --------------------MEPP-----------------------GGSLGPGRGTRDK B4DVR3_HUMAN B4DVR3_HUMAN --------------------M--------------------------------------- Q17RN4_HUMAN Q17RN4_HUMAN --------------------MEPP-----------------------GGSLGPGRGTRDK DIAP1_HUMAN DIAP1_HUMAN --------------------MEPP-----------------------GGSLGPGRGTRDK Q96IL1_HUMAN Q96IL1_HUMAN ------------------------------------------------------------ Q05CS5_MOUSE Q05CS5_MOUSE --------------------MEPS-----------------------GGGLGPGRGTRDK DIAP1_MOUSE DIAP1_MOUSE --------------------MEPS-----------------------GGGLGPGRGTRDK Q6NS79_MOUSE Q6NS79_MOUSE --------------------MA-------------------------------------- Q3U104_MOUSE Q3U104_MOUSE ------------------------------------------------------------ Q9DEH3_CHICK Q9DEH3_CHICK --------------------MEDQAAPGS------------------GGGDEPPGPTKMN Q3U4Y4_MOUSE Q3U4Y4_MOUSE --------------------MEELGAAAS-------------GAGGGGGGGEEHGGGRSN Q6W4W7_MOUSE Q6W4W7_MOUSE --------------------MEELGAAAS-------------GAGGGGGGGEEHGGGRSN DIAP2_MOUSE DIAP2_MOUSE --------------------MEELGAAAS-------------GAGGGGGGGEEHGGGRSN A8MSQ4_HUMAN A8MSQ4_HUMAN --------------------MEQPGAAAS----------------GAGGGSEEPGGGRSN DIAP2_HUMAN DIAP2_HUMAN --------------------MEQPGAAAS----------------GAGGGSEEPGGGRSN B3KMJ1_HUMAN B3KMJ1_HUMAN ------------------------------------------------------------ A8K5F7_HUMAN A8K5F7_HUMAN --------------------MEQPGAAAS----------------GAGGGSEEPGGGRSN A6NML8_HUMAN A6NML8_HUMAN --------------------MEQPGAAAS----------------GAGGGSEEPGGGRSN B7ZLJ0_HUMAN B7ZLJ0_HUMAN --------------------MEQPGAAAS----------------GAGGGSEEPGGGRSN Q17R91_HUMAN Q17R91_HUMAN --------------------MEQPGAAAS----------------GAGGGSEEPGGGRSN MATCH CONSENSUS ????????????????????M???????????????????????????????????????

Q5DTM7_MOUSE Q5DTM7_MOUSE LQ-SAPPAGPYEPGEKRPKLHLNIRTLTDDMLDKFASIRIPGSKKERPPLPHLKTVSGIS Q8K331_MOUSE Q8K331_MOUSE ------------------------------------------------------------ Q0VGT1_MOUSE Q0VGT1_MOUSE LQ-SAPPAGPYEPGEKRPKLHLNIRTLTDDMLDKFASIRIPGSKKERPPLPHLKTVSGIS DIAP3_MOUSE DIAP3_MOUSE LQ-SAPPAGPYEPGEKRPKLHLNIRTLTDDMLDKFASIRIPGSKKERPPLPHLKTVSGIS Q3TSX1_MOUSE Q3TSX1_MOUSE LQ-SAPPAGPYEPGEKRPKL-----------LDKFASIRIPGSKKERPPLPHLKTVSGIS Q5PR81_MOUSE Q5PR81_MOUSE LQ-SAPPAGPYEPGEKRPKLHLNIRTLTDDMLDKFASIRIPGSKKERPPLPHLKTVSGIS Q3UU77_MOUSE Q3UU77_MOUSE LQ-SAPPAGPYEPGEKRPKLHLNIRTLTDDMLDKFASIRIPGSKKERPPLPHLKTVSGIS Q4R7E4_MACFA Q4R7E4_MACFA ------------------------------------------------------------ A6NG52_HUMAN A6NG52_HUMAN ------------------------------------------------------------ A8MYX0_HUMAN A8MYX0_HUMAN PQHPPPPSGPEEPGEKRPKFHLNIRTLTDDMLDKFASIRIPGSKKERPPLPNLKTAFASS B7ZB09_HUMAN B7ZB09_HUMAN PQHPPPPSGPEEPGEKRPKFHLNIRTLTDDMLDKFASIRIPGSKKERPPLPNLKTAFASS B4DPV3_HUMAN B4DPV3_HUMAN PQHPPPPSGPEEPGEKRPKFHLNIRTLTDDMLDKFASIRIPGSKKERPPLPNLKTAFASS DIAP3_HUMAN DIAP3_HUMAN PQHPPPPSGPEEPGEKRPKFHLNIRTLTDDMLDKFASIRIPGSKKERPPLPNLKTAFASS Q4R8N9_MACFA Q4R8N9_MACFA ------------------------------------------------------------ Q7KZJ7_HUMAN Q7KZJ7_HUMAN ------------------------------------------------------------ A0RZB8_HUMAN A0RZB8_HUMAN KKGRSPDELPSAGGDGGKSKKF---------LERFTSMR--IKKEKEKPNSAHRNSSASY Q6URC4_HUMAN Q6URC4_HUMAN KKGRSPDELPSAGGDGGKSKKFTLKRLMADELERFTSMR--IKKEKEKPNSAHRNSSASY B4DVR3_HUMAN B4DVR3_HUMAN ------------------------------------------------------------ Q17RN4_HUMAN Q17RN4_HUMAN KKGRSPDELPSAGGDGGKSKKF---------LERFTSMR--IKKEKEKPNSAHRNSSASY DIAP1_HUMAN DIAP1_HUMAN KKGRSPDELPSAGGDGGKSKKFTLKRLMADELERFTSMR--IKKEKEKPNSAHRNSSASY Q96IL1_HUMAN Q96IL1_HUMAN ------------------------------------------------------------ Q05CS5_MOUSE Q05CS5_MOUSE KKGRSPDELPATGGDGGKHKKF---------LERFTSMR--IKKEKEKPNSAHRNSSASY DIAP1_MOUSE DIAP1_MOUSE KKGRSPDELPATGGDGGKHKKF---------LERFTSMR--IKKEKEKPNSAHRNSSASY Q6NS79_MOUSE Q6NS79_MOUSE -----------------------------DELERFTSMR--IKKEKEKPNSAHRNSSASY Q3U104_MOUSE Q3U104_MOUSE ------------------------------------------------------------ Q9DEH3_CHICK Q9DEH3_CHICK AKRSGRSS--EEETRNKTKLNIQIKTLADDVRDRITSFRKSTVRKEKPLIQHHVDTQPPI Q3U4Y4_MOUSE Q3U4Y4_MOUSE KRGAGNRAANEEETRNKPKL-----------RDRITSFRKSATKREKPVIQHSIDYQTAV Q6W4W7_MOUSE Q6W4W7_MOUSE KRGAGNRAANEEETRNKPKLNIQIKTLADDVRDRITSFRKSATKREKPVIQHSIDYQTAV DIAP2_MOUSE DIAP2_MOUSE KRGAGNRAANEEETRNKPKL-----------RDRITSFRKSATKREKPVIQHSIDYQTAV A8MSQ4_HUMAN A8MSQ4_HUMAN KRSAGNRAANEEETKNKPKLNIQIKTLADDVRDRITSFRKSTVKKEKPLIQHPIDSQVAM DIAP2_HUMAN DIAP2_HUMAN KRSAGNRAANEEETKNKPKLNIQIKTLADDVRDRITSFRKSTVKKEKPLIQHPIDSQVAM B3KMJ1_HUMAN B3KMJ1_HUMAN ------------------------------------------------------------ A8K5F7_HUMAN A8K5F7_HUMAN KRSAGNRAANEEETKNKPKLNIQIKTLADDVRDRITSFRKSTVKKEKPLIQHPIDSQVAM A6NML8_HUMAN A6NML8_HUMAN KRSAGNRAANEEETKNKPKLNIQIKTLADDVRDRITSFRKSTVKKEKPLIQHPIDSQVAM B7ZLJ0_HUMAN B7ZLJ0_HUMAN KRSAGNRAANEEETKNKPKLNIQIKTLADDVRDRITSFRKSTVKKEKPLIQHPIDSQVAM Q17R91_HUMAN Q17R91_HUMAN KRSAGNRAANEEETKNKPKLNIQIKTLADDVRDRITSFRKSTVKKEKPLIQHPIDSQVAM MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5DTM7_MOUSE Q5DTM7_MOUSE DSSSLSSETMENNPKALPESEVLKLFEKMMEDMNLNEDKKAPLREKDFGIKKEMVMQYIN Q8K331_MOUSE Q8K331_MOUSE ------------------------------------------------------------ Q0VGT1_MOUSE Q0VGT1_MOUSE DSSSLSSETMENNPKALPESEVLKLFEKMMEDMNLNEDKKAPLREKDFGIKKEMVMQYIN DIAP3_MOUSE DIAP3_MOUSE DSSSLSSETMENNPKALPESEVLKLFEKMMEDMNLNEDKKAPLREKDFGIKKEMVMQYIN Q3TSX1_MOUSE Q3TSX1_MOUSE DSSSLSSETMENNPKALPESEVLKLFEKMMEDMNLNEDKKAPLREKDFGIKKEMVMQYIN Q5PR81_MOUSE Q5PR81_MOUSE DSSSLSSETMENNPKALPESEVLKLFEKMMEDMNLNEDKKAPLREKDFGIKKEMVMQYIN Q3UU77_MOUSE Q3UU77_MOUSE DSSSLSSETMENNPKALPESEVLKLFEKMMEDMNLNEDKKAPLREKDFGIKKEMVMQYIN Q4R7E4_MACFA Q4R7E4_MACFA ------------------------------------------------------------ A6NG52_HUMAN A6NG52_HUMAN ------------------------------------------------------------ A8MYX0_HUMAN A8MYX0_HUMAN DCSAAPLEMMENFPKPLSENELLELFEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQYIN B7ZB09_HUMAN B7ZB09_HUMAN DCSAAPLEMMENFPKPLSENELLELFEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQYIN B4DPV3_HUMAN B4DPV3_HUMAN DCSAAPLEMMENFPKPLSENELLELFEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQYIN DIAP3_HUMAN DIAP3_HUMAN DCSAAPLEMMENFPKPLSENELLELFEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQYIN Q4R8N9_MACFA Q4R8N9_MACFA ------------------------------------------------------------ Q7KZJ7_HUMAN Q7KZJ7_HUMAN ------------------------------------------------------------ A0RZB8_HUMAN A0RZB8_HUMAN GDDPTAQSLQD-----VSDEQVLVLFEQMLLDMNLNEEKQQPLREKDIIIRREMVSQYLY Q6URC4_HUMAN Q6URC4_HUMAN GDDPTAQSLQD-----VSDEQVLVLFEQMLLDMNLNEEKQQPLREKDIIIKREMVSQYLY B4DVR3_HUMAN B4DVR3_HUMAN ------------------------------------------------------------ Q17RN4_HUMAN Q17RN4_HUMAN GDDPTAQSLQD-----VSDEQVLVLFEQMLLDMNLNEEKQQPLREKDIIIKREMVSQYLY DIAP1_HUMAN DIAP1_HUMAN GDDPTAQSLQD-----VSDEQVLVLFEQMLLDMNLNEEKQQPLREKDIIIKREMVSQYLY Q96IL1_HUMAN Q96IL1_HUMAN ------------------------------------------------------------ Q05CS5_MOUSE Q05CS5_MOUSE GDDPTAQSLQD-----ISDEQVLVLFEQMLVDMNLNEEKQQPLREKDIVIKREMVSQYLH DIAP1_MOUSE DIAP1_MOUSE GDDPTAQSLQD-----ISDEQVLVLFEQMLVDMNLNEEKQQPLREKDIVIKREMVSQYLH Q6NS79_MOUSE Q6NS79_MOUSE GDDPTAQSLQD-----ISDEQVLVLFEQMLVDMNLNEEKQQPLREKDIVIKREMVSQYLH Q3U104_MOUSE Q3U104_MOUSE ------------------------------------------------------------ Q9DEH3_CHICK Q9DEH3_CHICK SEIPLAQALLDERCMNLSEKEVMDLFEKMMEDMNLNEERKAPLREKDLSTKREMVVQYIS Q3U4Y4_MOUSE Q3U4Y4_MOUSE VEIPPALIVHDDRSLILSEKEVLDLFEKMMEDMNLNEEKKAPLRKKDFSIKREMVVQYIS Q6W4W7_MOUSE Q6W4W7_MOUSE VEIPPALIVHDDRSLILSEKEVLDLFEKMMEDMNLNEEKKAPLRKKDFSIKREMVVQYIS DIAP2_MOUSE DIAP2_MOUSE VEIPPALIVHDDRSLILSEKEVLDLFEKMMEDMNLNEEKKAPLRKKDFSIKREMVVQYIS A8MSQ4_HUMAN A8MSQ4_HUMAN SEFPAAQPLYDERSLNLSEKEVLDLFEKMMEDMNLNEEKKAPLRNKDFTTKREMVVQYIS DIAP2_HUMAN DIAP2_HUMAN SEFPAAQPLYDERSLNLSEKEVLDLFEKMMEDMNLNEEKKAPLRNKDFTTKREMVVQYIS B3KMJ1_HUMAN B3KMJ1_HUMAN ------------------------------------------------------------ A8K5F7_HUMAN A8K5F7_HUMAN SEFPAAQPLYDERSLNLSEKEVLDLFEKMMEDMNLNEEKKAPLRNKDFTTKREMVVQYIS A6NML8_HUMAN A6NML8_HUMAN SEFPAAQPLYDERSLNLSEKEVLDLFEKMMEDMNLNEEKKAPLRNKDFTTKREMVVQYIS B7ZLJ0_HUMAN B7ZLJ0_HUMAN SEFPAAQPLYDERSLNLSEKEVLDLFEKMMEDMNLNEEKKAPLRNKDFTTKREMVVQYIS Q17R91_HUMAN Q17R91_HUMAN SEFPAAQPLYDERSLNLSEKEVLDLFEKMMEDMNLNEEKKAPLRNKDFTTKREMVVQYIS MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5DTM7_MOUSE Q5DTM7_MOUSE TASKT-------GSLRSSRQ---ISPQEFLHELKMGYTDERLFTYLESLRVSLTSHPVSW Q8K331_MOUSE Q8K331_MOUSE ------------------------------------------------------------ Q0VGT1_MOUSE Q0VGT1_MOUSE TASKT-------GSLRSSRQ---ISPQEFLHELKMGYTDERLFTYLESLRVSLTSHPVSW DIAP3_MOUSE DIAP3_MOUSE TASKT-------GSLRSSRQ---ISPQEFLHELKMGYTDERLFTYLESLRVSLTSHPVSW Q3TSX1_MOUSE Q3TSX1_MOUSE TASKT-------GSLRSSRQ---ISPQEFLHELKMGYTDERLFTYLESLRVSLTSHPVSW Q5PR81_MOUSE Q5PR81_MOUSE TASKT-------GSLRSSRQ---ISPQEFLHELKMGYTDERLFTYLESLRVSLTSHPVSW Q3UU77_MOUSE Q3UU77_MOUSE TASKT-------GSLRSSRQ---ISPQEFLHELKMGYTDERLFTYLESLRVSLTSHPVSW Q4R7E4_MACFA Q4R7E4_MACFA ------------------------------------------------------------ A6NG52_HUMAN A6NG52_HUMAN ------------------------------------------------------------ A8MYX0_HUMAN A8MYX0_HUMAN TASKT-------GSLKRSRQ---ISPQEFIHELKMGSADERLVTCLESLRVSLTSNPVSW B7ZB09_HUMAN B7ZB09_HUMAN TASKT-------GSLKRSRQ---ISPQEFIHELKMGSADERLVTCLESLRVSLTSNPVSW B4DPV3_HUMAN B4DPV3_HUMAN TASKT-------GSLKRSRQ---ISPQEFIHELKMGSADERLVTCLESLRVSLTSNPVSW DIAP3_HUMAN DIAP3_HUMAN TASKT-------GSLKRSRQ---ISPQEFIHELKMGSADERLVTCLESLRVSLTSNPVSW Q4R8N9_MACFA Q4R8N9_MACFA ------------------------------------------------------------ Q7KZJ7_HUMAN Q7KZJ7_HUMAN ------------------------------------------------------------ A0RZB8_HUMAN A0RZB8_HUMAN TSKAG-----------MSQKESSKSAMMYIQELRSGLRDMPLLSCLESLRVSLNNNPVSW Q6URC4_HUMAN Q6URC4_HUMAN TSKAG-----------MSQKESSKSAMMYIQELRSGLRDMPLLSCLESLRVSLNNNPVSW B4DVR3_HUMAN B4DVR3_HUMAN ------------------------------------------------------------ Q17RN4_HUMAN Q17RN4_HUMAN TSKAG-----------MSQKESSKSAMMYIQELRSGLRDMPLLSCLESLRVSLNNNPVSW DIAP1_HUMAN DIAP1_HUMAN TSKAG-----------MSQKESSKSAMMYIQELRSGLRDMPLLSCLESLRVSLNNNPVSW Q96IL1_HUMAN Q96IL1_HUMAN ------------------------------------------------------------ Q05CS5_MOUSE Q05CS5_MOUSE TSKAG-----------MNQKESSRSAMMYIQELRSGLRDMHLLSCLESLRVSLNNNPVSW DIAP1_MOUSE DIAP1_MOUSE TSKAG-----------MNQKESSRSAMMYIQELRSGLRDMHLLSCLESLRVSLNNNPVSW Q6NS79_MOUSE Q6NS79_MOUSE TSKAG-----------MNQKESSRSAMMYIQELRSGLRDMHLLSCLESLRVSLNNNPVSW Q3U104_MOUSE Q3U104_MOUSE ------------------------------------------------------------ Q9DEH3_CHICK Q9DEH3_CHICK ATAKS-------GGLKNSKHECTLSSQEYIHELRSGIAEEKLLNCLESLRVSLTSNPVSW Q3U4Y4_MOUSE Q3U4Y4_MOUSE ATSKSIVGSKVLGGLKNSKHEFTLSSQEYVHELRSGISDEKLLNCLESLRVSLTSHPVSW Q6W4W7_MOUSE Q6W4W7_MOUSE ATSKS-------GGLKNSKHEFTLSSQEYVHELRSGISDEKLLNCLESLRVSLTSHPVSW DIAP2_MOUSE DIAP2_MOUSE ATSKSIVGSKVLGGLKNSKHEFTLSSQEYVHELRSGISDEKLLNCLESLRVSLTSHPVSW A8MSQ4_HUMAN A8MSQ4_HUMAN ATAKS-------GGLKNSKHECTLSSQEYVHELRSGISDEKLLNCLESLRVSLTSNPVSW DIAP2_HUMAN DIAP2_HUMAN ATAKS-------GGLKNSKHECTLSSQEYVHELRSGISDEKLLNCLESLRVSLTSNPVSW B3KMJ1_HUMAN B3KMJ1_HUMAN ------------------------------------------------------------ A8K5F7_HUMAN A8K5F7_HUMAN ATAKS-------GGLKNSKHGCTLSSQEYVHELRSGISDEKLLNCLESLRVSLTSNPVSW A6NML8_HUMAN A6NML8_HUMAN ATAKS-------GGLKNSKHECTLSSQEYVHELRSGISDEKLLNCLESLRVSLTSNPVSW B7ZLJ0_HUMAN B7ZLJ0_HUMAN ATAKSIVGSKVTGGLKNSKHECTLSSQEYVHELRSGISDEKLLNCLESLRVSLTSNPVSW Q17R91_HUMAN Q17R91_HUMAN ATAKSIVGSKVTGGLKNSKHECTLSSQEYVHELRSGISDEKLLNCLESLRVSLTSNPVSW MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5DTM7_MOUSE Q5DTM7_MOUSE VQSFGHEGLGLLLDILEKLINGQIQE--KVVKKTQHKVIQCLRALMNTQYGLERIMSDKR Q8K331_MOUSE Q8K331_MOUSE -------------------------------------------------------MSDKR Q0VGT1_MOUSE Q0VGT1_MOUSE VQSFGHEGLGLLLDILEKLINGQIQE--KVVKKTQHKVIQCLRALMNTQYGLERIMSDKR DIAP3_MOUSE DIAP3_MOUSE VQSFGHEGLGLLLDILEKLINGQIQE--KVVKKTQHKVIQCLRALMNTQYGLERIMSDKR Q3TSX1_MOUSE Q3TSX1_MOUSE VQSFGHEGLGLLLDILEKLINGQIQE--KVVKKTQHKVIQCLRALMNTQYGLERIMSDKR Q5PR81_MOUSE Q5PR81_MOUSE VQSFGHEGLGLLLDILEKLINGQIQE--KVVKKTQHKVIQCLRALMNTQYGLERIMSDKR Q3UU77_MOUSE Q3UU77_MOUSE VQSFGHEGLGLLLDILEKLINGQIQE--KVVKKTQHKVIQCLRALMNTQYGLERIMSDKR Q4R7E4_MACFA Q4R7E4_MACFA ------------------------------------------------------------ A6NG52_HUMAN A6NG52_HUMAN -------------------------------------------------------MSEER A8MYX0_HUMAN A8MYX0_HUMAN VESFGHEGLGLLLDILEKLISGKIQE--KVVKKNQHKVIQCLKALMNTQYGLERIMSEER B7ZB09_HUMAN B7ZB09_HUMAN VESFGHEGLGLLLDILEKLISGKIQE--KVVKKNQHKVIQCLKALMNTQYGLERIMSEGR B4DPV3_HUMAN B4DPV3_HUMAN VESFGHEGLGLLLDILEKLISGKIQE--KVVKKNQHKVIQCLKALMNTQYGLERIMSEER DIAP3_HUMAN DIAP3_HUMAN VESFGHEGLGLLLDILEKLISGKIQE--KVVKKNQHKVIQCLKALMNTQYGLERIMSEER Q4R8N9_MACFA Q4R8N9_MACFA ------------------------------------------------------------ Q7KZJ7_HUMAN Q7KZJ7_HUMAN ------------------------------------------------------------ A0RZB8_HUMAN A0RZB8_HUMAN VQTFGAEGLASLLDILKRLHGEKEETAGSYDSRNKHEIIRCLKAFMNNKFGIKAMLETEE Q6URC4_HUMAN Q6URC4_HUMAN VQTFGAEGLASLLDILKRLHDEKEETAGSYDSRNKHEIIRCLKAFMNNKFGIKTMLETEE B4DVR3_HUMAN B4DVR3_HUMAN ------------------------------------------------------------ Q17RN4_HUMAN Q17RN4_HUMAN VQTFGAEGLASLLDILKRLHDEKEETAGSYDSRNKHEIIRCLKAFMNNKFGIKTMLETEE DIAP1_HUMAN DIAP1_HUMAN VQTFGAEGLASLLDILKRLHDEKEETAGSYDSRNKHEIIRCLKAFMNNKFGIKTMLETEE Q96IL1_HUMAN Q96IL1_HUMAN ------------------------------------------------------------ Q05CS5_MOUSE Q05CS5_MOUSE VQTFGAEGLASLLDILKRLHDEKEETSGNYDSRNQHEIIRCLKAFMNNKFGIKTMLETEE DIAP1_MOUSE DIAP1_MOUSE VQTFGAEGLASLLDILKRLHDEKEETSGNYDSRNQHEIIRCLKAFMNNKFGIKTMLETEE Q6NS79_MOUSE Q6NS79_MOUSE VQTFGAEGLASLLDILKRLHDEKEETSGNYDSRNQHEIIRCLKAFMNNKFGIKTMLETEE Q3U104_MOUSE Q3U104_MOUSE ------------------------------------------------------------ Q9DEH3_CHICK Q9DEH3_CHICK VNNFGHEGLGLLLDALERLLDKKQQE--NIDKKNQHKLIQCLKAFMNNKYGLQRILGDER Q3U4Y4_MOUSE Q3U4Y4_MOUSE VNNFGYEGLGVLLDVLEKLLDKKQQE--NIDKKNQYKVIQCLKAFMNNKFGLQRILGDER Q6W4W7_MOUSE Q6W4W7_MOUSE VNNFGYEGLGVLLDVLEKLLDKKQQE--NIDKKNQYKVIQCLKAFMNNKFGLQRILGDER DIAP2_MOUSE DIAP2_MOUSE VNNFGYEGLGVLLDVLEKLLDKKQQE--NIDKKNQYKVIQCLKAFMNNKFGLQRILGDER A8MSQ4_HUMAN A8MSQ4_HUMAN VNNFGHEGLGLLLDELEKLLDKKQQE--NIDKKNQYKLIQCLKAFMNNKFGLQRILGDER DIAP2_HUMAN DIAP2_HUMAN VNNFGHEGLGLLLDELEKLLDKKQQE--NIDKKNQYKLIQCLKAFMNNKFGLQRILGDER B3KMJ1_HUMAN B3KMJ1_HUMAN ------------------------------------------------------------ A8K5F7_HUMAN A8K5F7_HUMAN VNNFGHEGLGLLLDELEKLLDKKQQE--NIDKKNQYKLIQCLKAFMNNKFGLQRILGDER A6NML8_HUMAN A6NML8_HUMAN VNNFGHEGLGLLLDELEKLLDKKQQE--NIDKKNQYKLIQCLKAFMNNKFGLQRILGDER B7ZLJ0_HUMAN B7ZLJ0_HUMAN VNNFGHEGLGLLLDELEKLLDKKQQE--NIDKKNQYKLIQCLKAFMNNKFGLQRILGDER Q17R91_HUMAN Q17R91_HUMAN VNNFGHEGLGLLLDELEKLLDKKQQE--NIDKKNQYKLIQCLKAFMNNKFGLQRILGDER MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5DTM7_MOUSE Q5DTM7_MOUSE SLSLLAKAMDPRQPAMMADVVKLLSAVCIVGE-ESILEEVLEALTSAGEERKIDRFFSIV Q8K331_MOUSE Q8K331_MOUSE SLSLLAKAMDPRQPAMMADVVKLLSAVCIVGE-ESILEEVLEALTSAGEERKIDRFFSIV Q0VGT1_MOUSE Q0VGT1_MOUSE SLSLLAKAMDPRQPAMMADVVKLLSAVCIVGE-ESILEEVLEALTSAGEERKIDRFFSIV DIAP3_MOUSE DIAP3_MOUSE SLSLLAKAMDPRQPAMMADVVKLLSAVCIVGE-ESILEEVLEALTSAGEERKIDRFFSIV Q3TSX1_MOUSE Q3TSX1_MOUSE SLSLLAKAMDPRQPAMMADVVKLLSAVCIVGE-ESILEEVLEALTSAGEERKIDRFFSIV Q5PR81_MOUSE Q5PR81_MOUSE SLSLLAKAMDPRQPAMMADVVKLLSAVCIVGE-ESILEEVLEALTSAGEERKIDRFFSIV Q3UU77_MOUSE Q3UU77_MOUSE SLSLLAKAMDPRQPAMMADVVKLLSAVCIVGE-ESILEEVLEALTSAGEERKIDRFFSIV Q4R7E4_MACFA Q4R7E4_MACFA ------------------------------------------------------------ A6NG52_HUMAN A6NG52_HUMAN SLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGE-ESILEEVLEALTSAGEEKKIDRFFCIV A8MYX0_HUMAN A8MYX0_HUMAN SLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGE-ESILEEVLEALTSAGEEKKIDRFFCIV B7ZB09_HUMAN B7ZB09_HUMAN SLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGE-ESILEEVLEALTSAGEEKKIDRFFCIV B4DPV3_HUMAN B4DPV3_HUMAN SLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGE-ESILEEVLEALTSAGEEKKIDRFFCIV DIAP3_HUMAN DIAP3_HUMAN SLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGE-ESILEEVLEALTSAGEEKKIDRFFCIV Q4R8N9_MACFA Q4R8N9_MACFA ------------------------------------------------------------ Q7KZJ7_HUMAN Q7KZJ7_HUMAN ------------------------------------------------------------ A0RZB8_HUMAN A0RZB8_HUMAN GILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEMDEVERFQPLL Q6URC4_HUMAN Q6URC4_HUMAN GILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEMDEVERFQPLL B4DVR3_HUMAN B4DVR3_HUMAN ------------------------------------------------------------ Q17RN4_HUMAN Q17RN4_HUMAN GILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEMDEVERFQPLL DIAP1_HUMAN DIAP1_HUMAN GILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEMDEVERFQPLL Q96IL1_HUMAN Q96IL1_HUMAN ------------------------------------------------------------ Q05CS5_MOUSE Q05CS5_MOUSE GILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEMDEVERFQPLL DIAP1_MOUSE DIAP1_MOUSE GILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEMDEVERFQPLL Q6NS79_MOUSE Q6NS79_MOUSE GILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEMDEVERFQPLL Q3U104_MOUSE Q3U104_MOUSE ------------------------------------------------------------ Q9DEH3_CHICK Q9DEH3_CHICK SLLLLSRAIDPKQPHMMTETVKILSAICIVGE-ERILDKVLGAITTAAERNNRERFSPVV Q3U4Y4_MOUSE Q3U4Y4_MOUSE SLLLLARAIDPKQQNMMTEIVKILSAICIVGE-ENILDKLLGGITAAAELNNRERFSPIV Q6W4W7_MOUSE Q6W4W7_MOUSE SLLLLARAIDPKQQNMMTEIVKILSAICIVGE-ENILDKLLGGITAAAELNNRERFSPIV DIAP2_MOUSE DIAP2_MOUSE SLLLLARAIDPKQQNMMTEIVKILSAICIVGE-ENILDKLLGGITAAAELNNRERFSPIV A8MSQ4_HUMAN A8MSQ4_HUMAN SLLLLARAIDPKQPNMMTEIVKILSAICIVGE-ENILDKLLGAITTAAERNNRERFSPIV DIAP2_HUMAN DIAP2_HUMAN SLLLLARAIDPKQPNMMTEIVKILSAICIVGE-ENILDKLLGAITTAAERNNRERFSPIV B3KMJ1_HUMAN B3KMJ1_HUMAN ------------------------------------------------------------ A8K5F7_HUMAN A8K5F7_HUMAN SLLLLARAIDPKQPNMMTEIVKILSAICIVGE-ENILDKLLGAITTAAERNNRERFSPIV A6NML8_HUMAN A6NML8_HUMAN SLLLLARAIDPKQPNMMTEIVKILSAICIVGE-ENILDKLLGAITTAAERNNRERFSPIV B7ZLJ0_HUMAN B7ZLJ0_HUMAN SLLLLARAIDPKQPNMMTEIVKILSAICIVGE-ENILDKLLGAITTAAERNNRERFSPIV Q17R91_HUMAN Q17R91_HUMAN SLLLLARAIDPKQPNMMTEIVKILSAICIVGE-ENILDKLLGAITTAAERNNRERFSPIV MATCH CONSENSUS ???LL??A?DP????MM????K?LSA?CI????E??????L???T???E?????RF????

Q5DTM7_MOUSE Q5DTM7_MOUSE EGLR-HNSVNLQVACMQLINALVTSPDDLDFRLHLRNEFMRCGLKEILPNLKGIKNDGLD Q8K331_MOUSE Q8K331_MOUSE EGLR-HNSVNLQVACMQLINALVTSPDDLDFRLHLRNEFMRCGLKEILPNLKGIKNDGLD Q0VGT1_MOUSE Q0VGT1_MOUSE EGLR-HNSVNLQVACMQLINALVTSPDDLDFRLHLRNEFMRCGLKEILPNLKGIKNDGLD DIAP3_MOUSE DIAP3_MOUSE EGLR-HNSVNLQVACMQLINALVTSPDDLDFRLHLRNEFMRCGLKEILPNLKGIKNDGLD Q3TSX1_MOUSE Q3TSX1_MOUSE EGLR-HNSVNLQVACMQLINALVTSPDDLDFRLHLRNEFMRCGLKEILPNLKGIKNDGLD Q5PR81_MOUSE Q5PR81_MOUSE EGLR-HNSVNLQVACMQLINALVTSPDDLDFRLHLRNEFMRCGLKEILPNLKGIKNDGLD Q3UU77_MOUSE Q3UU77_MOUSE EGLR-HNSVNLQVACMQLINALVTSPDDLDFRLHLRNEFMRCGLKEILPNLKGIKNDGLD Q4R7E4_MACFA Q4R7E4_MACFA ---------------MQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKNDGLD A6NG52_HUMAN A6NG52_HUMAN EGLR-HNSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKNDGLD A8MYX0_HUMAN A8MYX0_HUMAN EGLR-HNSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKNDGLD B7ZB09_HUMAN B7ZB09_HUMAN EGLR-HNSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKNDGLD B4DPV3_HUMAN B4DPV3_HUMAN EGLR-HNSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKNDGLD DIAP3_HUMAN DIAP3_HUMAN EGLR-HNSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKNDGLD Q4R8N9_MACFA Q4R8N9_MACFA ------------------------------------------------------------ Q7KZJ7_HUMAN Q7KZJ7_HUMAN ------------------------------------------------------------ A0RZB8_HUMAN A0RZB8_HUMAN DGLKSGTTIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQDLREIENEDMR Q6URC4_HUMAN Q6URC4_HUMAN DGLKSGTTIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQDLREIENEDMR B4DVR3_HUMAN B4DVR3_HUMAN ------------------------------------------------------------ Q17RN4_HUMAN Q17RN4_HUMAN DGLKSGTTIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQDLREIENEDMR DIAP1_HUMAN DIAP1_HUMAN DGLKSGTTIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQDLREIENEDMR Q96IL1_HUMAN Q96IL1_HUMAN ------------------------------------------------------------ Q05CS5_MOUSE Q05CS5_MOUSE DGLKSGTSIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQELREIENEDMK DIAP1_MOUSE DIAP1_MOUSE DGLKSGTSIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQELREIENEDMK Q6NS79_MOUSE Q6NS79_MOUSE DGLKSGTSIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQELREIENEDMK Q3U104_MOUSE Q3U104_MOUSE ---------------MASLSAVVVAPS--------------VSSSAAVPPAPPLPGD--- Q9DEH3_CHICK Q9DEH3_CHICK EGLENHEFLQLQVACMQFINALVTSPEELDFRIHLRNEFLRCGLKKILPALKEKENEELD Q3U4Y4_MOUSE Q3U4Y4_MOUSE EGLENNEALHLQVACMQFINALVTSPYDLDFRIHLRNEFLRCGLKAMLPTLKEIENEGLD Q6W4W7_MOUSE Q6W4W7_MOUSE EGLENNEALHLQVACMQFINALVTSPYDLDFRIHLRNEFLRCGLKAMLPTLKEIENEGLD DIAP2_MOUSE DIAP2_MOUSE EGLENNEALHLQVACMQFINALVTSPYDLDFRIHLRNEFLRCGLKAMLPTLKEIENEGLD A8MSQ4_HUMAN A8MSQ4_HUMAN EGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKTMLPDLKEKENDELD DIAP2_HUMAN DIAP2_HUMAN EGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKTMLPDLKEKENDELD B3KMJ1_HUMAN B3KMJ1_HUMAN ------------------------------------------------------------ A8K5F7_HUMAN A8K5F7_HUMAN EGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKTMLSDLKEKENDELD A6NML8_HUMAN A6NML8_HUMAN EGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKTMLPDLKEKENDELD B7ZLJ0_HUMAN B7ZLJ0_HUMAN EGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKTMLPDLKEKENDELD Q17R91_HUMAN Q17R91_HUMAN EGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKTMLPDLKEKENDELD MATCH CONSENSUS ?GL???????L?V?C?Q?INAL?T????LDFR?H?R?E??R?GL???L??L????N????

Q5DTM7_MOUSE Q5DTM7_MOUSE IQLKVFDEHKEEDLNEFFHRLEDIRAELDEASDVYSMLWDTVKETRAEGHFLSILQHLLL Q8K331_MOUSE Q8K331_MOUSE IQLKVFDEHKEEDLSEFFHRLEDIRAELDEASDVYSMLWDTVKETRAEGHFLSILQHLLL Q0VGT1_MOUSE Q0VGT1_MOUSE IQLKVFDEHKEEDLSEFFHRLEDIRAELDEASDVYSMLWDTVKETRAEGHFLSILQHLLL DIAP3_MOUSE DIAP3_MOUSE IQLKVFDEHKEEDLSEFFHRLEDIRAELDEASDVYSMLWDTVKETRAEGHFLSILQHLLL Q3TSX1_MOUSE Q3TSX1_MOUSE IQLKVFDEHKEEDLSEFFHRLEDIRAELDEASDVYSMLWDTVKETRAEGHFLSILQHLLL Q5PR81_MOUSE Q5PR81_MOUSE IQLKVFDEHKEEDLSEFFHRLEDIRAELDEASDVYSMLWDTVKETRAEGHFLSILQHLLL Q3UU77_MOUSE Q3UU77_MOUSE IQLKVFDEHKEEDLSEFFHRLEDIRAELDEASDVYSMLWDTVKETRAEGHFLSILQHLLL Q4R7E4_MACFA Q4R7E4_MACFA IQLKVFDEHKEEDLIELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQHLLL A6NG52_HUMAN A6NG52_HUMAN IQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQHLLL A8MYX0_HUMAN A8MYX0_HUMAN IQLKVFDEHKEEDLFELSHRLEDIRAELEYPYDVYNMVWSTVKETRAEGYFISILQHLLL B7ZB09_HUMAN B7ZB09_HUMAN IQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQHLLL B4DPV3_HUMAN B4DPV3_HUMAN IQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQHLLL DIAP3_HUMAN DIAP3_HUMAN IQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQHLLL Q4R8N9_MACFA Q4R8N9_MACFA ------------------------------------------------------------ Q7KZJ7_HUMAN Q7KZJ7_HUMAN ------------------------------------------------------------ A0RZB8_HUMAN A0RZB8_HUMAN VQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSILQHLLL Q6URC4_HUMAN Q6URC4_HUMAN VQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSILQHLLL B4DVR3_HUMAN B4DVR3_HUMAN ------------------------------------------------------------ Q17RN4_HUMAN Q17RN4_HUMAN VQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSILQHLLL DIAP1_HUMAN DIAP1_HUMAN VQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSILQHLLL Q96IL1_HUMAN Q96IL1_HUMAN ------------------------------------------------------------ Q05CS5_MOUSE Q05CS5_MOUSE VQLCVFDEQGDEDFFDLKGRLDDIRMEMDDFGEVFQIILNTVKDSKAEPHFLSILQHLLL DIAP1_MOUSE DIAP1_MOUSE VQLCVFDEQGDEDFFDLKGRLDDIRMEMDDFGEVFQIILNTVKDSKAEPHFLSILQHLLL Q6NS79_MOUSE Q6NS79_MOUSE VQLCVFDEQGDEDFFDLKGRLDDIRMEMDDFGEVFQIILNTVKDSKAEPHFLSILQHLLL Q3U104_MOUSE Q3U104_MOUSE ------------------------------------------------------------ Q9DEH3_CHICK Q9DEH3_CHICK IQLKVFDESKEEDLIELSHRLNDIRVEMDDVNEVFQFLYNMLKDTSSENHFLSILQHFLL Q3U4Y4_MOUSE Q3U4Y4_MOUSE IQLRVFEENKEDDLSELSHRLNDIRAEMDDINEVYHLLYNMLKDTAAEPYLLSILQHFLL Q6W4W7_MOUSE Q6W4W7_MOUSE IQLRVFEENKEDDLSELSHRLNDIRAEMDDINEVYHLLYNMLKDTAAEPYLLSILQHFLL DIAP2_MOUSE DIAP2_MOUSE IQLRVFEENKEDDLSELSHRLNDIRAEMDDINEVYHLLYNMLKDTAAEPYLLSILQHFLL A8MSQ4_HUMAN A8MSQ4_HUMAN IQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTAAENYFLSILQHFLL DIAP2_HUMAN DIAP2_HUMAN IQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTAAENYFLSILQHFLL B3KMJ1_HUMAN B3KMJ1_HUMAN ------------------------------------------------------------ A8K5F7_HUMAN A8K5F7_HUMAN IQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTAAENYFLSILQHFLL A6NML8_HUMAN A6NML8_HUMAN IQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTAAENYFLSILQHFLL B7ZLJ0_HUMAN B7ZLJ0_HUMAN IQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTAAENYFLSILQHFLL Q17R91_HUMAN Q17R91_HUMAN IQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTAAENYFLSILQHFLL MATCH CONSENSUS ?QL?VF?E????D??????RL?DIR?E?D????V????????K???AE????SILQH?LL

Q5DTM7_MOUSE Q5DTM7_MOUSE IRNDRFIREQYFKLIDECVSQIVLHRDGTDPDFTYRKRLDLDLSQFVDVCIDQAKLDEWE Q8K331_MOUSE Q8K331_MOUSE IRNDRFIREQYFKLIDECVSQIVLHRDGTDPDFTYRKRLDLDLSQFVDVCIDQAKLDEWE Q0VGT1_MOUSE Q0VGT1_MOUSE IRNDRFIREQYFKLIDECVSQIVLHRDGTDPDFTYRKRLDLDLSQFVDVCIDQAKLDEWE DIAP3_MOUSE DIAP3_MOUSE IRNDRFIREQYFKLIDECVSQIVLHRDGTDPDFTYRKRLDLDLSQFVDVCIDQAKLDEWE Q3TSX1_MOUSE Q3TSX1_MOUSE IRNDRFIREQYFKLIDECVSQIVLHRDGTDPDFTYRKRLDLDLSQFVDVCIDQAKLDEWE Q5PR81_MOUSE Q5PR81_MOUSE IRNDRFIREQYFKLIDECVSQIVLHRDGTDPDFTYRKRLDLDLSQFVDVCIDQAKLDEWE Q3UU77_MOUSE Q3UU77_MOUSE IRNDRFIREQYFKLIDECVSQIVLHRDGTDPDFTYRKRLDLDLSQFVDVCIDQAKLDEWE Q4R7E4_MACFA Q4R7E4_MACFA IRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTEFVDICVDQAKLEEFE A6NG52_HUMAN A6NG52_HUMAN IRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLEEFE A8MYX0_HUMAN A8MYX0_HUMAN IRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLEEFE B7ZB09_HUMAN B7ZB09_HUMAN IRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLEEFE B4DPV3_HUMAN B4DPV3_HUMAN IRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLEEFE DIAP3_HUMAN DIAP3_HUMAN IRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLEEFE Q4R8N9_MACFA Q4R8N9_MACFA ------------------------------------------------------------ Q7KZJ7_HUMAN Q7KZJ7_HUMAN ------------------------------------------------------------ A0RZB8_HUMAN A0RZB8_HUMAN VRNDYEARPQYYKLIEECISQIVLHKNGADPDFKCR-HLQIEIEGLIDQMIDKTKVEKSE Q6URC4_HUMAN Q6URC4_HUMAN VRNDYEARPQYYKLIEECISQIVLHKNGADPDFKCR-HLQIEIEGLIDQMIDKTKVEKSE B4DVR3_HUMAN B4DVR3_HUMAN ------------------------------------------------------------ Q17RN4_HUMAN Q17RN4_HUMAN VRNDYEARPQYYKLIEECISQIVLHKNGADPDFKCR-HLQIEIEGLIDQMIDKTKVEKSE DIAP1_HUMAN DIAP1_HUMAN VRNDYEARPQYYKLIEECISQIVLHKNGADPDFKCR-HLQIEIEGLIDQMIDKTKVEKSE Q96IL1_HUMAN Q96IL1_HUMAN ------------------------------------------------------------ Q05CS5_MOUSE Q05CS5_MOUSE VRNDYEARPQYYKLIEECVSQIVLHKNGTDPDFKCR-HLQIDIERLVDQMIDKTKVEKSE DIAP1_MOUSE DIAP1_MOUSE VRNDYEARPQYYKLIEECVSQIVLHKNGTDPDFKCR-HLQIDIERLVDQMIDKTKVEKSE Q6NS79_MOUSE Q6NS79_MOUSE VRNDYEARPQYYKLIEECVSQIVLHKNGTDPDFKCR-HLQIDIERLVDQMIDKTKVEKSE Q3U104_MOUSE Q3U104_MOUSE -------------------SGTVIPPPPPPPPLPG------------------------- Q9DEH3_CHICK Q9DEH3_CHICK IRNDYYVRPQYYKIIEECVSQIVLHTSGMDPDFSCRGRMDVDFSHLIDASVDKTKVEESE Q3U4Y4_MOUSE Q3U4Y4_MOUSE IRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRIDFDFTHLLDACVNKAKVEENE Q6W4W7_MOUSE Q6W4W7_MOUSE IRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRIDFDFTHLLDACVNKAKVEENE DIAP2_MOUSE DIAP2_MOUSE IRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRIDFDFTHLLDACVNKAKVEENE A8MSQ4_HUMAN A8MSQ4_HUMAN IRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTHLIDSCVNKAKVEESE DIAP2_HUMAN DIAP2_HUMAN IRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTHLIDSCVNKAKVEESE B3KMJ1_HUMAN B3KMJ1_HUMAN ----------------------------MDPDFKYRQRLDIDLTHLIDSCVNKAKVEESE A8K5F7_HUMAN A8K5F7_HUMAN IRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTHLIDSCVNKAKVEESE A6NML8_HUMAN A6NML8_HUMAN IRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTHLIDSCVNKAKVEESE B7ZLJ0_HUMAN B7ZLJ0_HUMAN IRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDLKYRQRLDIDLTHLIDSCVNKAKVEESE Q17R91_HUMAN Q17R91_HUMAN IRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTHLIDSCVNKAKVEESE MATCH CONSENSUS ?RND???R?QY?K?I?EC?SQIVLH??G?DPDF??R???????????D??????K????E

Q5DTM7_MOUSE Q5DTM7_MOUSE EKASEHCKKFEKECTDHQETQAQLQKREAKI-------------------------NELQ Q8K331_MOUSE Q8K331_MOUSE EKASEHCKKFEKECTDHQETQAQLQKREAKI-------------------------NELQ Q0VGT1_MOUSE Q0VGT1_MOUSE EKASEHCKKFEKECTDHQETQAQLQKREAKI-------------------------NELQ DIAP3_MOUSE DIAP3_MOUSE EKASEHCKKFEKECTDHQETQAQLQKREAKI-------------------------NELQ Q3TSX1_MOUSE Q3TSX1_MOUSE EKASEHCKKFEKECTDHQETQAQLQKREAKI-------------------------NELQ Q5PR81_MOUSE Q5PR81_MOUSE EKASEHCKKFEKECTDHQETQAQLQKREAKI-------------------------NELQ Q3UU77_MOUSE Q3UU77_MOUSE EKASEHCKKFEKECTDHQETQAQLQKREAKI-------------------------NELQ Q4R7E4_MACFA Q4R7E4_MACFA EKASELYKKFEKEFTDHQETQAELQKKEAKI-------------------------NELQ A6NG52_HUMAN A6NG52_HUMAN EKASELYKKFEKEFTDHQETQAELQKKEAKI-------------------------NELQ A8MYX0_HUMAN A8MYX0_HUMAN EKASELYKKFEKEFTDHQETQAELQKKEAKI-------------------------NELQ B7ZB09_HUMAN B7ZB09_HUMAN EKASELYKKFEKEFTDHQETQAELQKKEAKI-------------------------NELQ B4DPV3_HUMAN B4DPV3_HUMAN EKASELYKKFEKEFTDHQETQAELQKKEAKI-------------------------NELQ DIAP3_HUMAN DIAP3_HUMAN EKASELYKKFEKEFTDHQETQAELQKKEAKI-------------------------NELQ Q4R8N9_MACFA Q4R8N9_MACFA ------------------------------------------------------------ Q7KZJ7_HUMAN Q7KZJ7_HUMAN ------------------------------------------------------------ A0RZB8_HUMAN A0RZB8_HUMAN AKAAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQIATEKQDLE Q6URC4_HUMAN Q6URC4_HUMAN AKAAELGKKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQIATEKQDLE B4DVR3_HUMAN B4DVR3_HUMAN ------------------------------------------------------------ Q17RN4_HUMAN Q17RN4_HUMAN AKAAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQIATEKQDLE DIAP1_HUMAN DIAP1_HUMAN AKAAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQIATEKQDLE Q96IL1_HUMAN Q96IL1_HUMAN ------------------------------------------------------------ Q05CS5_MOUSE Q05CS5_MOUSE AKATELEKKLDSELTARHELQVEMKKMENDFEQKLQDLQGEKDALDSEKQQITAQKQDLE DIAP1_MOUSE DIAP1_MOUSE AKATELEKKLDSELTARHELQVEMKKMENDFEQKLQDLQGEKDALDSEKQQITAQKQDLE Q6NS79_MOUSE Q6NS79_MOUSE AKATELEKKLDSELTARHELQVEMKKMENDFEQKLQDLQGEKDALDSEKQQITAQKQDLE Q3U104_MOUSE Q3U104_MOUSE ------------------------------------------------------------ Q9DEH3_CHICK Q9DEH3_CHICK KKAAEFSKKFDEEFIARQEAQAALQKREEKI-------------------------KELE Q3U4Y4_MOUSE Q3U4Y4_MOUSE QKAMEFSKKFDEEFTARQEAQAELQKRDEKI-------------------------KELE Q6W4W7_MOUSE Q6W4W7_MOUSE QKAMEFSKKFDEEFTARQEAQAELQKRDEKI-------------------------KELE DIAP2_MOUSE DIAP2_MOUSE QKAMEFSKKFDEEFTARQEAQAELQKRDEKI-------------------------KELE A8MSQ4_HUMAN A8MSQ4_HUMAN QKAAEFSKKFDEEFTARQEAQAELQKRDEKI-------------------------KELE DIAP2_HUMAN DIAP2_HUMAN QKAAEFSKKFDEEFTARQEAQAELQKRDEKI-------------------------KELE B3KMJ1_HUMAN B3KMJ1_HUMAN QKAAEFSKKFDEEFTARQEAQAELQKRDEKI-------------------------KELE A8K5F7_HUMAN A8K5F7_HUMAN QKAAEFSKKFDEEFTARQEAQAELQKRDEKI-------------------------KELE A6NML8_HUMAN A6NML8_HUMAN QKAAEFSKKFDEEFTARQEAQAELQKRDEKI-------------------------KELE B7ZLJ0_HUMAN B7ZLJ0_HUMAN QKAAEFSKKFDEEFTARQEAQAELQKRDEKI-------------------------KELE Q17R91_HUMAN Q17R91_HUMAN QKAAEFSKKFDEEFTARQEAQAELQKRDEKI-------------------------KELE MATCH CONSENSUS ?KA?E??KK???E?T???E?Q????K????????????????????????????????L?

Q5DTM7_MOUSE Q5DTM7_MOUSE AELQAFKSQF-------------------------------GALP--------------- Q8K331_MOUSE Q8K331_MOUSE AELQAFKSQF-------------------------------GALP--------------- Q0VGT1_MOUSE Q0VGT1_MOUSE AELQAFKSQF-------------------------------GALP--------------- DIAP3_MOUSE DIAP3_MOUSE AELQAFKSQF-------------------------------GALP--------------- Q3TSX1_MOUSE Q3TSX1_MOUSE AELQAFKSQF-------------------------------GALP--------------- Q5PR81_MOUSE Q5PR81_MOUSE AELQAFKSQF-------------------------------GALP--------------- Q3UU77_MOUSE Q3UU77_MOUSE AELQAFKSQF-------------------------------GALP--------------- Q4R7E4_MACFA Q4R7E4_MACFA TELQAFKSQF-------------------------------GALP--------------- A6NG52_HUMAN A6NG52_HUMAN AELQAFKSQF-------------------------------GALP--------------- A8MYX0_HUMAN A8MYX0_HUMAN AELQAFKSQF-------------------------------GALP--------------- B7ZB09_HUMAN B7ZB09_HUMAN AELQAFKSQF-------------------------------GALP--------------- B4DPV3_HUMAN B4DPV3_HUMAN AELQAFKSQF-------------------------------GALP--------------- DIAP3_HUMAN DIAP3_HUMAN AELQAFKSQF-------------------------------GALP--------------- Q4R8N9_MACFA Q4R8N9_MACFA ------------------------------------------------------------ Q7KZJ7_HUMAN Q7KZJ7_HUMAN ------------------------------------------------------------ A0RZB8_HUMAN A0RZB8_HUMAN AEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPP Q6URC4_HUMAN Q6URC4_HUMAN AEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPP B4DVR3_HUMAN B4DVR3_HUMAN ------------------------------------------------------------ Q17RN4_HUMAN Q17RN4_HUMAN AEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPP DIAP1_HUMAN DIAP1_HUMAN AEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPP Q96IL1_HUMAN Q96IL1_HUMAN ------------------------------------------------------------ Q05CS5_MOUSE Q05CS5_MOUSE AEVSKLTGEVAKLSKELEDAKNEMASLS--AVVVAPSVSSSAAVPPAPPLPGDSGTVIPP DIAP1_MOUSE DIAP1_MOUSE AEVSKLTGEVAKLSKELEDAKNEMASLS--AVVVAPSVSSSAAVPPAPPLPGDSGTVIPP Q6NS79_MOUSE Q6NS79_MOUSE AEVSKLTGEVAKLSKELEDAKNEMASLS--AVVVAPSVSSSAAVPPAPPLPGDSGTVIPP Q3U104_MOUSE Q3U104_MOUSE -----------------------------------------GVVPPSPSLP--------- Q9DEH3_CHICK Q9DEH3_CHICK TEIKRLRSQVPPPASVNVLPSSAASLLPGGTVPPSPPALSSGVVP--------------- Q3U4Y4_MOUSE Q3U4Y4_MOUSE TEIQQLRGQG-----------------------------VPSAIP--------------- Q6W4W7_MOUSE Q6W4W7_MOUSE TEIQQLRGQG-----------------------------VPSAIP--------------- DIAP2_MOUSE DIAP2_MOUSE TEIQQLRGQG-----------------------------VPSAIP--------------- A8MSQ4_HUMAN A8MSQ4_HUMAN AEIQQLRTQA-------------------------QVLSSSSGIP--------------- DIAP2_HUMAN DIAP2_HUMAN AEIQQLRTQA-------------------------QVLSSSSGIP--------------- B3KMJ1_HUMAN B3KMJ1_HUMAN AEIQQLRTQA-------------------------QVLSSSSGIP--------------- A8K5F7_HUMAN A8K5F7_HUMAN AEIQQLRTQA-------------------------QVLSSSSGIP--------------- A6NML8_HUMAN A6NML8_HUMAN AEIQQLRTQA-------------------------QVLSSSSGIP--------------- B7ZLJ0_HUMAN B7ZLJ0_HUMAN AEIQQLRTQA-------------------------QVLSSSSGIP--------------- Q17R91_HUMAN Q17R91_HUMAN AEIQQLRTQA-------------------------QVLSSSSGIP--------------- MATCH CONSENSUS ?E??????????????????????????????????????????P???????????????

Q5DTM7_MOUSE Q5DTM7_MOUSE -------------------PGTKIPLQPSVEGEA-------------------------- Q8K331_MOUSE Q8K331_MOUSE -------------------PGTKIPLQPSVEGEA-------------------------- Q0VGT1_MOUSE Q0VGT1_MOUSE -------------------LGTKIPLQPSVEGEA-------------------------- DIAP3_MOUSE DIAP3_MOUSE -------------------PGTKIPLQPSVEGEA-------------------------- Q3TSX1_MOUSE Q3TSX1_MOUSE -------------------PGTKIPLQPSVEGEA-------------------------- Q5PR81_MOUSE Q5PR81_MOUSE -------------------PGTKIPLQPSVEGEA-------------------------- Q3UU77_MOUSE Q3UU77_MOUSE -------------------PGTKIPLQPSVEGEA-------------------------- Q4R7E4_MACFA Q4R7E4_MACFA -------------------VDCNIPLPPSKEGGT-------------------------- A6NG52_HUMAN A6NG52_HUMAN -------------------ADCNIPLPPSKEGGT-------------------------- A8MYX0_HUMAN A8MYX0_HUMAN -------------------ADCNIPLPPSKEGGT-------------------------- B7ZB09_HUMAN B7ZB09_HUMAN -------------------ADCNIPLPPSKEGGT-------------------------- B4DPV3_HUMAN B4DPV3_HUMAN -------------------ADCNIPLPPSKEGGT-------------------------- DIAP3_HUMAN DIAP3_HUMAN -------------------ADCNIPLPPSKEGGT-------------------------- Q4R8N9_MACFA Q4R8N9_MACFA ------------------------------------------------------------ Q7KZJ7_HUMAN Q7KZJ7_HUMAN ------------------------------------------------------------ A0RZB8_HUMAN A0RZB8_HUMAN PPAPG-------DSTT-PPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATI Q6URC4_HUMAN Q6URC4_HUMAN PPAPG-------DSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATI B4DVR3_HUMAN B4DVR3_HUMAN ------------------------------------------------------------ Q17RN4_HUMAN Q17RN4_HUMAN PPAPG-------DSTT-PPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATI DIAP1_HUMAN DIAP1_HUMAN PPAPG-------DSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATI Q96IL1_HUMAN Q96IL1_HUMAN ------------------------------------------------------------ Q05CS5_MOUSE Q05CS5_MOUSE PPPPPPLPGGVVPPSPPLPPGTCIPPPPPLPGGACIPPPPQLP----------------- DIAP1_MOUSE DIAP1_MOUSE PPPPPPLPGGVVPPSPPLPPGTCIPPPPPLPGGACIPPPPQLPGSAAIPPPPPLPGVASI Q6NS79_MOUSE Q6NS79_MOUSE PPPPPPLPGGVVPPSPPLPPGTCIPPPPPLPGGACIPPPPQLPGSAAIPPPPPLPGVASI Q3U104_MOUSE Q3U104_MOUSE -------------------PGTCIPPPPPLPGGACIPPPPQLPGSAAIPPPPPLP----- Q9DEH3_CHICK Q9DEH3_CHICK ---------------------LPPPPPPPLPGGAAIPPAPPLPGGAAIPPAPPLPGGTVV Q3U4Y4_MOUSE Q3U4Y4_MOUSE ----------------------GPPPPPPLPGA--------------------------- Q6W4W7_MOUSE Q6W4W7_MOUSE ----------------------GPPPPPPLPGA--------------------------- DIAP2_MOUSE DIAP2_MOUSE ----------------------GPPPPPPLPGA--------------------------- A8MSQ4_HUMAN A8MSQ4_HUMAN ----------------------GPPAAPPLPGV--------------------------- DIAP2_HUMAN DIAP2_HUMAN ----------------------GPPAAPPLPGV--------------------------- B3KMJ1_HUMAN B3KMJ1_HUMAN ----------------------GPPAAPPLPGV--------------------------- A8K5F7_HUMAN A8K5F7_HUMAN ----------------------GPPAAPPLPGV--------------------------- A6NML8_HUMAN A6NML8_HUMAN ----------------------GPPAAPPLPGV--------------------------- B7ZLJ0_HUMAN B7ZLJ0_HUMAN ----------------------GPPAAPPLPGV--------------------------- Q17R91_HUMAN Q17R91_HUMAN ----------------------GPPAAPPLPGV--------------------------- MATCH CONSENSUS ????????????????????????P??P???G????????????????????????????

Q5DTM7_MOUSE Q5DTM7_MOUSE ----------------------------------CPSALPPAPPALSGGVPPPPPPP--- Q8K331_MOUSE Q8K331_MOUSE ----------------------------------GPSALPPAPPALSGGVPPPPPPP--- Q0VGT1_MOUSE Q0VGT1_MOUSE ----------------------------------GPSALPPAPPALSGGVPPPPPPP--- DIAP3_MOUSE DIAP3_MOUSE ----------------------------------GPSALPPAPPALSGGVPPPPPPP--- Q3TSX1_MOUSE Q3TSX1_MOUSE ----------------------------------GPSALPPAPPALSGGVPPPPPPP--- Q5PR81_MOUSE Q5PR81_MOUSE ----------------------------------GPSALPPAPPALSGGVPPPPPPP--- Q3UU77_MOUSE Q3UU77_MOUSE ----------------------------------GPSALPPAPPALSGGVPPPPPPP--- Q4R7E4_MACFA Q4R7E4_MACFA ----------------------------------GHSALPPPPPLPSGG-GVPPPPP--- A6NG52_HUMAN A6NG52_HUMAN ----------------------------------GHSALPPPPPLPSGG-GVPPPPP--- A8MYX0_HUMAN A8MYX0_HUMAN ----------------------------------GHSALPPPPPLPSGG-GVPPPPP--- B7ZB09_HUMAN B7ZB09_HUMAN ----------------------------------GHSALPPPPPLPSGG-GVPPPPP--- B4DPV3_HUMAN B4DPV3_HUMAN ----------------------------------GHSALPPPPPLPSGGGVLPPPP---- DIAP3_HUMAN DIAP3_HUMAN ----------------------------------GHSALPPPPPLPSGG-GVPPPPP--- Q4R8N9_MACFA Q4R8N9_MACFA --------------------------------------PPPPPPLPGGPGIPPPP----- Q7KZJ7_HUMAN Q7KZJ7_HUMAN ------------------------------------------------------------ A0RZB8_HUMAN A0RZB8_HUMAN PPPPPLPEGVGI--PSPSSLPGSTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPG Q6URC4_HUMAN Q6URC4_HUMAN PPPPPLPEGVGI--PSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPG B4DVR3_HUMAN B4DVR3_HUMAN --------------------------------------PPPPPPLPGGPGIPPPP----- Q17RN4_HUMAN Q17RN4_HUMAN PPPPPLPEGVGI--PSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPG DIAP1_HUMAN DIAP1_HUMAN PPPPPLPEGVGI--PSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPG Q96IL1_HUMAN Q96IL1_HUMAN ------------------------------------------------------------ Q05CS5_MOUSE Q05CS5_MOUSE ----------------------------------GSAAIPPPPPLPGVA-SIPPPPPLPG DIAP1_MOUSE DIAP1_MOUSE PPPPPLPGATAIPPPPPLP---------------GATAIPPPPPLPGGTGIPPPPPPLPG Q6NS79_MOUSE Q6NS79_MOUSE PPPPPLPGATAIPPPPPLP---------------GATAIPPPPPLPGGTGIPPPPPPLPG Q3U104_MOUSE Q3U104_MOUSE ----------------------------------GVASIPPPPPLPGGTGIPPPPPPLPG Q9DEH3_CHICK Q9DEH3_CHICK PPAPPLPGGAAVIPPPPPLPGGAAVIPPPPPLPGGAAVIPPPPPLPGGAAVIPPPPPLPG Q3U4Y4_MOUSE Q3U4Y4_MOUSE ----------------------------------GPCPPPPPPP--------PPPPPLPG Q6W4W7_MOUSE Q6W4W7_MOUSE ----------------------------------GPCPPPPPPP--------PPPPPLPG DIAP2_MOUSE DIAP2_MOUSE ----------------------------------GPCPPPPPPP--------PPPPPLPG A8MSQ4_HUMAN A8MSQ4_HUMAN ----------------------------------GPPPPPPAPPLPGGAPLPPPPPPLPG DIAP2_HUMAN DIAP2_HUMAN ----------------------------------GPPPPPPAPPLPGGAPLPPPPPPLPG B3KMJ1_HUMAN B3KMJ1_HUMAN ----------------------------------GPPPPPPAPPLPGGAPLPPPPPPLPG A8K5F7_HUMAN A8K5F7_HUMAN ----------------------------------GPPPPPPAPPLPGGAPLPPPPPPLPG A6NML8_HUMAN A6NML8_HUMAN ----------------------------------GPPPPPPAPPLPGGAPLPPPPPPLPG B7ZLJ0_HUMAN B7ZLJ0_HUMAN ----------------------------------GPPPPPPAPPLPGGAPLPPPPPPLPG Q17R91_HUMAN Q17R91_HUMAN ----------------------------------GPPPPPPAPPLPGGAPLPPPPPPLPG MATCH CONSENSUS ???????????????????????????????????????PP?PP????????PPPPP???

Q5DTM7_MOUSE Q5DTM7_MOUSE ----PPPPPPLPG--------------------------------------------MPM Q8K331_MOUSE Q8K331_MOUSE ----PPPPPPLPG--------------------------------------------MPM Q0VGT1_MOUSE Q0VGT1_MOUSE ----PPPPPPLPG--------------------------------------------MPM DIAP3_MOUSE DIAP3_MOUSE ----PPPPPPLPG--------------------------------------------MPM Q3TSX1_MOUSE Q3TSX1_MOUSE ----PPPPPPLPG--------------------------------------------MPM Q5PR81_MOUSE Q5PR81_MOUSE ----PPPPPPLPG--------------------------------------------MPM Q3UU77_MOUSE Q3UU77_MOUSE ----PPPPPPLPG--------------------------------------------MPM Q4R7E4_MACFA Q4R7E4_MACFA ----PPPPPPLPG--------------------------------------------MRM A6NG52_HUMAN A6NG52_HUMAN ----PPPPPPLPG--------------------------------------------MRM A8MYX0_HUMAN A8MYX0_HUMAN ----PPPPPPLPG--------------------------------------------MRM B7ZB09_HUMAN B7ZB09_HUMAN ----PPPPPPLPG--------------------------------------------MRM B4DPV3_HUMAN B4DPV3_HUMAN ----PPPPPPLPG--------------------------------------------MRM DIAP3_HUMAN DIAP3_HUMAN ----PPPPPPLPG--------------------------------------------MRM Q4R8N9_MACFA Q4R8N9_MACFA ----------------------------------------------------------PF Q7KZJ7_HUMAN Q7KZJ7_HUMAN ------------------------------------------------------------ A0RZB8_HUMAN A0RZB8_HUMAN EAGMPPPPPPLPGGPGI-P------------------------------------PPPPF Q6URC4_HUMAN Q6URC4_HUMAN EAGMPPPPPPLPGGPGI-P------------------------------------PPPPF B4DVR3_HUMAN B4DVR3_HUMAN ----------------------------------------------------------PF Q17RN4_HUMAN Q17RN4_HUMAN EAGMPPPPPPLPGGPGI-P------------------------------------PPPPF DIAP1_HUMAN DIAP1_HUMAN EAGMPPPPPPLPGGPGI-P------------------------------------PPPPF Q96IL1_HUMAN Q96IL1_HUMAN ------------------------------------------------------------ Q05CS5_MOUSE Q05CS5_MOUSE ATA-IPPPPPLPGATAIP-------------------------------------PPPPL DIAP1_MOUSE DIAP1_MOUSE SVG-VPPPPPLPGGPGLPP------------------------------------PPPPF Q6NS79_MOUSE Q6NS79_MOUSE SVG-VPPPPPLPGGPGLPP------------------------------------PPPPF Q3U104_MOUSE Q3U104_MOUSE SVG-VPPPPPLPGGPGLPP------------------------------------PPPPF Q9DEH3_CHICK Q9DEH3_CHICK GAAVIPPPPPLPGGAAVIPPPPLLPGGTVIPPPPPLPGGAAAVLPPPPPLPGGTIPPPPP Q3U4Y4_MOUSE Q3U4Y4_MOUSE VV--PPPPPPLPG--------------------------------------------MP- Q6W4W7_MOUSE Q6W4W7_MOUSE VV--PPPPPPLPG--------------------------------------------MP- DIAP2_MOUSE DIAP2_MOUSE VV--PPPPPPLPG--------------------------------------------MP- A8MSQ4_HUMAN A8MSQ4_HUMAN MMGIPPPPPP------------------------------------------------PL DIAP2_HUMAN DIAP2_HUMAN MMGIPPPPPP------------------------------------------------PL B3KMJ1_HUMAN B3KMJ1_HUMAN MMGIPPPPPP------------------------------------------------PL A8K5F7_HUMAN A8K5F7_HUMAN MMGIPPPPPP------------------------------------------------PL A6NML8_HUMAN A6NML8_HUMAN MMGIPPPPPP------------------------------------------------PL B7ZLJ0_HUMAN B7ZLJ0_HUMAN MMGIPPPPPP------------------------------------------------PL Q17R91_HUMAN Q17R91_HUMAN MMGIPPPPPP------------------------------------------------PL MATCH CONSENSUS ?????PPPPP??????????????????????????????????????????????????

Q5DTM7_MOUSE Q5DTM7_MOUSE PFGGPVPPPPPLGFLGG----QSSIPL-------------------N-LPFGLKPKKEFK Q8K331_MOUSE Q8K331_MOUSE PFGGPVPPPPPLGFLGG----QSSIPL--------------------NLPFGLKPKKEFK Q0VGT1_MOUSE Q0VGT1_MOUSE PFGGPVPPPPPLGFLGG----QSSIPL--------------------NLPFGLKPKKEFK DIAP3_MOUSE DIAP3_MOUSE PFGGPVPPPPPLGFLGG----QSSIPL--------------------NLPFGLKPKKEFK Q3TSX1_MOUSE Q3TSX1_MOUSE PFGGPVPPPPPLGFLGG----QSSIPL--------------------NLPFGLKPKKEFK Q5PR81_MOUSE Q5PR81_MOUSE PFGGPVPPPPPLGFLGG----QSSIPL-------------------N-LPFGLKPKKEFK Q3UU77_MOUSE Q3UU77_MOUSE PFGGPVPPPPPLGFLGG----QSSIPL--------------------NLPFGLKPKKEFK Q4R7E4_MACFA Q4R7E4_MACFA PLGGPVPPPPPLGFLGG----QNSPPL-------------------PTLPFGLKPKKEFK A6NG52_HUMAN A6NG52_HUMAN PFSGPVPPPPPLGFLGG----QNSPPL-------------------PILPFGLKPKKEFK A8MYX0_HUMAN A8MYX0_HUMAN PFSGPVPPPPPLGFLGG----QNSPPL-------------------PILPFGLKPKKEFK B7ZB09_HUMAN B7ZB09_HUMAN PFSGPVPPPPPLGFLGG----QNSPPL-------------------PILPFGLKPKKEFK B4DPV3_HUMAN B4DPV3_HUMAN PFSGPVPPPPPLGFLGG----QNSPPL-------------------PILPFGLKPKKEFK DIAP3_HUMAN DIAP3_HUMAN PFSGPVPPPPPLGFLGG----QNSPPL-------------------PILPFGLKPKKEFK Q4R8N9_MACFA Q4R8N9_MACFA PGGPGIPPPPPG--MGM----PPPPPFG------------FGASAAPVLPFGLTPKKLYK Q7KZJ7_HUMAN Q7KZJ7_HUMAN ------------------------------------------------------------ A0RZB8_HUMAN A0RZB8_HUMAN PGGPGIPPPPPG--MGM----PPPPPFG----------F--GVPAAPVLPFGLTPKKLYK Q6URC4_HUMAN Q6URC4_HUMAN PGGPGIPPPPPG--MGM----PPPPPFG----------F--GVPAAPVLPFGLTPKKLYK B4DVR3_HUMAN B4DVR3_HUMAN PGGPGIPPPPPG--MGM----PPPPPFG------------FGVPAAPVLPFGLTPKKLYK Q17RN4_HUMAN Q17RN4_HUMAN PGGPGIPPPPPG--MGM----PPPPPFG----------F--GVPAAPVLPFGLTPKKLYK DIAP1_HUMAN DIAP1_HUMAN PGGPGIPPPPPG--MGM----PPPPPFG----------F--GVPAAPVLPFGLTPKKLYK Q96IL1_HUMAN Q96IL1_HUMAN ------------------------------------------------------------ Q05CS5_MOUSE Q05CS5_MOUSE PGGTGIPPPPPP--LPGSVGVPPPPPL----------------PGGPGLP---------- DIAP1_MOUSE DIAP1_MOUSE PGAPGIPPPPPG--MGV----PPPPPFG----------F--GVPAAPVLPFGLTPKKVYK Q6NS79_MOUSE Q6NS79_MOUSE PGAPGIPPPPPG--MGV----PPPPPFG----------F--GVPAAPVLPFGLTPKKVYK Q3U104_MOUSE Q3U104_MOUSE PGAPGIPPPPPG--MGV----PPPPPFG----------F--GVPAAPVLPFGLTPKKVYK Q9DEH3_CHICK Q9DEH3_CHICK LFGGAVPPPPPL--PGGGAGPPPPPPGGPPMAPSLGSYPFAPVPVMPALPHGMKEKKKYN Q3U4Y4_MOUSE Q3U4Y4_MOUSE --GIPPPPPPPLSGVPP----PPPPPGG----------VFPLLSGPIELPYGMKQKKLYK Q6W4W7_MOUSE Q6W4W7_MOUSE --GIPPPPPPPLSGVPP----PPPPPGG----------VFPLLSGPIELPYGMKQKKLYK DIAP2_MOUSE DIAP2_MOUSE --GIPPPPPPPLSGVPP----PPPPPGG----------VFPLLSGPIELPYGMKQKKLYK A8MSQ4_HUMAN A8MSQ4_HUMAN LFGGPPPPPP----LGG----VPPPPG-----------------ISLNLPYGMKQKKMYK DIAP2_HUMAN DIAP2_HUMAN LFGGPPPPPP----LGG----VPPPPG-----------------ISLNLPYGMKQKKMYK B3KMJ1_HUMAN B3KMJ1_HUMAN LFGGPPPPPP----LGG----VPPPPG-----------------ISLNLPYGMKQKKMYK A8K5F7_HUMAN A8K5F7_HUMAN LFGGPPPPPP----LGG----VPPPPG-----------------ISLNLPYGMKQKKMYK A6NML8_HUMAN A6NML8_HUMAN LFGGPPPPPP----LGG----VPPPPG-----------------ISLNLPYGMKQKKMYK B7ZLJ0_HUMAN B7ZLJ0_HUMAN LFGGPPPPPP----LGG----VPPPPG-----------------ISLNLPYGMKQKKMYK Q17R91_HUMAN Q17R91_HUMAN LFGGPPPPPP----LGG----VPPPPG-----------------ISLNLPYGMKQKKMYK MATCH CONSENSUS ??????PPPP?????G?????????P??????????????????????LP?G???KK??K

Q5DTM7_MOUSE Q5DTM7_MOUSE PEISMRRLNWLKIGPNEMSENCFWIKVNENKYENRDLLCKLENTFCCQEKEKRNTNDFD- Q8K331_MOUSE Q8K331_MOUSE PEISMRRLNWLKIGPNEMSENCFWIKVNENKYENRDLLCKLENTFCCQDKEKRNTNDFD- Q0VGT1_MOUSE Q0VGT1_MOUSE PEISMRRLNWLKIGPNEMSENCFWIKVNENKYENRDLLCKLENTFCCQEKEKRNTNDFD- DIAP3_MOUSE DIAP3_MOUSE PEISMRRLNWLKIGPNEMSENCFWIKVNENKYENRDLLCKLENTFCCQEKEKRNTNDFD- Q3TSX1_MOUSE Q3TSX1_MOUSE PEISMRRLNWLKIGPNEMSENCFWIKVNENKYENRDLLCKLENTFCCQEKEKRNTNDFD- Q5PR81_MOUSE Q5PR81_MOUSE PEISMRRLNWLKIGPNEMSENCFWIKVNENKYENRDLLCKLENTFCCQEKEKRNTNDFD- Q3UU77_MOUSE Q3UU77_MOUSE PEISMRRLNWLKIGPNEMSENCFWIKVNENKYENRDLLCKLENTFCCQEKEKRNTNDFD- Q4R7E4_MACFA Q4R7E4_MACFA PEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDTE- A6NG52_HUMAN A6NG52_HUMAN PEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDIE- A8MYX0_HUMAN A8MYX0_HUMAN PEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDIE- B7ZB09_HUMAN B7ZB09_HUMAN PEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDIE- B4DPV3_HUMAN B4DPV3_HUMAN PEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDIE- DIAP3_HUMAN DIAP3_HUMAN PEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDIE- Q4R8N9_MACFA Q4R8N9_MACFA PEVQLRRPNWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLTFSAQTKTSKAKKDQEG Q7KZJ7_HUMAN Q7KZJ7_HUMAN ------------------------------------------------------------ A0RZB8_HUMAN A0RZB8_HUMAN PEVQLRRPNWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLTFSAQTKTSKAKKDQEG Q6URC4_HUMAN Q6URC4_HUMAN PEVQLRRPNWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLTFSAQTKTSKAKKDQEG B4DVR3_HUMAN B4DVR3_HUMAN PEVQLRRPNWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLTFSAQTKTSKAKKDQEG Q17RN4_HUMAN Q17RN4_HUMAN PEVQLRRPNWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLTFSAQTKTSKAKKDQEG DIAP1_HUMAN DIAP1_HUMAN PEVQLRRPNWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLTFSAQTKTSKAKKDQEG Q96IL1_HUMAN Q96IL1_HUMAN ------------------------------------------LTFSAQTKTSKAKKDQEG Q05CS5_MOUSE Q05CS5_MOUSE ------------------------------------------------------------ DIAP1_MOUSE DIAP1_MOUSE PEVQLRRPNWSKFVAEDLSQDCFWTKVKEDRFENNELFAKLTLAFSAQTKTSKAKKDQEG Q6NS79_MOUSE Q6NS79_MOUSE PEVQLRRPNWSKFVAEDLSQDCFWTKVKEDRFENNELFAKLTLAFSAQTKTSKAKKDQEG Q3U104_MOUSE Q3U104_MOUSE PEVQLRRPNWSKFVAEDLSQDCFWTKVKEDRFENNELFAKLTLAFSAQTKTSKAKKDQEG Q9DEH3_CHICK Q9DEH3_CHICK VEVSMKRINWSKIEPYKIAENSFWVKAEENKFESPELFARLAVTFGTQMKAKKAVEKQE- Q3U4Y4_MOUSE Q3U4Y4_MOUSE PDIPMKRINWSKIEPKELSENCVWLKLKEEKYENADLFAKLALTFPSQMKGQRNTEAAE- Q6W4W7_MOUSE Q6W4W7_MOUSE PDIPMKRINWSKIEPKELSENCVWLKLKEEKYENADLFAKLALTFPSQMKGQRNTEAAE- DIAP2_MOUSE DIAP2_MOUSE PDIPMKRINWSKIEPKELSENCVWLKLKEEKYENADLFAKLALTFPSQMKGQRNTEAAE- A8MSQ4_HUMAN A8MSQ4_HUMAN PEVSMKRINWSKIEPTELSENCFWLRVKEDKFENPDLFAKLALNFATQIKVQKNAEALE- DIAP2_HUMAN DIAP2_HUMAN PEVSMKRINWSKIEPTELSENCFWLRVKEDKFENPDLFAKLALNFATQIKVQKNAEALE- B3KMJ1_HUMAN B3KMJ1_HUMAN PEVSMKRINWSKIEPTELSENCFWLRVKEDKFENPDLFAKLALNFATQIKVQKNAEALE- A8K5F7_HUMAN A8K5F7_HUMAN PEVSMKRINWSKIEPTELSENCFWLRVKEDKFENPDLFAKLALNFATQIKVQKNAEALE- A6NML8_HUMAN A6NML8_HUMAN PEVSMKRINWSKIEPTELSENCFWLRVKEDKFENPDLFAKLALNFATQIKVQKNAEALE- B7ZLJ0_HUMAN B7ZLJ0_HUMAN PEVSMKRINWSKIEPTELSENCFWLRVKEDKFENPDLFAKLALNFATQIKVQKNAEALE- Q17R91_HUMAN Q17R91_HUMAN PEVSMKRINWSKIEPTELSENCFWLRVKEDKFENPDLFAKLALNFATQIKVQKNAEALE- MATCH CONSENSUS PE????R?NW?K?????????CFW??V?E???EN??L??KL???F??Q?K??????????

Q5DTM7_MOUSE Q5DTM7_MOUSE ---EKKVIKKRMKELKFLDPKIAQNLSIFLSSFRVPYEKIRTMILEVDETQLSESMIQNL Q8K331_MOUSE Q8K331_MOUSE ---EKKVIKKRMKELKFLDPKIAQNLSIFLSSFRVPYEKIRTMILEVDETQLSESMIQNL Q0VGT1_MOUSE Q0VGT1_MOUSE ---EKKVIKKRMKELKFLDPKIAQNLSIFLSSFRVPYEKIRTMILEVDETQLSESMIQNL DIAP3_MOUSE DIAP3_MOUSE ---EKKVIKKRMKELKFLDPKIAQNLSIFLSSFRVPYEKIRTMILEVDETQLSESMIQNL Q3TSX1_MOUSE Q3TSX1_MOUSE ---EKKVIKKRMKELKFLDPKIAQNLSIFLSSFRVPYEKIRTMILEVDETQLSESMIQNL Q5PR81_MOUSE Q5PR81_MOUSE ---EKKVIKKRMKELKFLDPKIAQNLSIFLSSFRVPYEKIRTMILEVDETQLSESMIQNL Q3UU77_MOUSE Q3UU77_MOUSE ---EKKVIKKRMKELKFLDPKIAQNLSIFLSSFRVPYEKIRTMILEVDETQLSESMIQNL Q4R7E4_MACFA Q4R7E4_MACFA ---EKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNL A6NG52_HUMAN A6NG52_HUMAN ---EKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNL A8MYX0_HUMAN A8MYX0_HUMAN ---EKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNL B7ZB09_HUMAN B7ZB09_HUMAN ---EKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNL B4DPV3_HUMAN B4DPV3_HUMAN ---EKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNL DIAP3_HUMAN DIAP3_HUMAN ---EKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNL Q4R8N9_MACFA Q4R8N9_MACFA GEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNAILEVNEAVLTESMIQNL Q7KZJ7_HUMAN Q7KZJ7_HUMAN ----------------------------------MPYQEIKNVILEVNEAVLTESMIQNL A0RZB8_HUMAN A0RZB8_HUMAN GEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNL Q6URC4_HUMAN Q6URC4_HUMAN GEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNL B4DVR3_HUMAN B4DVR3_HUMAN GEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNL Q17RN4_HUMAN Q17RN4_HUMAN GEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNL DIAP1_HUMAN DIAP1_HUMAN GEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNL Q96IL1_HUMAN Q96IL1_HUMAN GEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNL Q05CS5_MOUSE Q05CS5_MOUSE ------------------------------------------------------------ DIAP1_MOUSE DIAP1_MOUSE GEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNL Q6NS79_MOUSE Q6NS79_MOUSE GEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNL Q3U104_MOUSE Q3U104_MOUSE GEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNL Q9DEH3_CHICK Q9DEH3_CHICK -EKKTEQSKKKNKVLRVLDGKTSQNLSIFLGSQRMPYEEIKNIILEVNEEKLTETFVQAV Q3U4Y4_MOUSE Q3U4Y4_MOUSE -ENRSGPPKKKVKELRILDTKTAQNLSIFLGSYRMPYEEIKNIILEVNEEMLSEALIQNL Q6W4W7_MOUSE Q6W4W7_MOUSE -ENRSGPPKKKVKELRILDTKTAQNLSIFLGSYRMPYEEIKNIILEVNEEMLSEALIQNL DIAP2_MOUSE DIAP2_MOUSE -ENRSGPPKKKVKELRILDTKTAQNLSIFLGSYRMPYEEIKNIILEVNEEMLSEALIQNL A8MSQ4_HUMAN A8MSQ4_HUMAN -EKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLSEALIQNL DIAP2_HUMAN DIAP2_HUMAN -EKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLSEALIQNL B3KMJ1_HUMAN B3KMJ1_HUMAN -EKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLSEALIQNL A8K5F7_HUMAN A8K5F7_HUMAN -EKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILEVNGDMLSEALIQNL A6NML8_HUMAN A6NML8_HUMAN -EKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLSEALIQNL B7ZLJ0_HUMAN B7ZLJ0_HUMAN -EKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLSEALIQNL Q17R91_HUMAN Q17R91_HUMAN -EKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLSEALIQNL MATCH CONSENSUS ????????KK??KEL??LD?K?AQNLSIFL?S?R?PY??I???ILEV?E??L?E??IQNL

Q5DTM7_MOUSE Q5DTM7_MOUSE IKHLPDEEQLKSLSQFRSDYNSLCEPEQFAVVMSNVKRLRPRLSAILFKLQFEEQVNNIK Q8K331_MOUSE Q8K331_MOUSE IKHLPDEEQLKSLSQFRSDYNSLCEPEQFAVVMSNVKRLRPRLSAILFKLQFEEQVNNIK Q0VGT1_MOUSE Q0VGT1_MOUSE IKHLPDEEQLKSLSQFRSDYNSLCEPEQFAVVMSNVKRLRPRLSAILFKLQFEEQVNNIK DIAP3_MOUSE DIAP3_MOUSE IKHLPDEEQLKSLSQFRSDYNSLCEPEQFAVVMSNVKRLRPRLSAILFKLQFEEQVNNIK Q3TSX1_MOUSE Q3TSX1_MOUSE IKHLPDEEQLKSLSQFRSDYNSLCEPEQFAVVMSNVKRLRPRLSAILFKLQFEEQVNNIK Q5PR81_MOUSE Q5PR81_MOUSE IKHLPDEEQLKSLSQFRSDYNSLCEPEQFAVVMSNVKRLRPRLSAILFKLQFEEQVNNIK Q3UU77_MOUSE Q3UU77_MOUSE IKHLPDEEQLKSLSQFRSDYNSLCEPEQFAVVMSNVKRLRPRLSAILFKLQFEEQVNNIK Q4R7E4_MACFA Q4R7E4_MACFA IKHLPDQEQLNSLSQFKSEYNNLCEPEQFAVVMSNVKRLRPRLSAILFKLQFEEQVNNIK A6NG52_HUMAN A6NG52_HUMAN IKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIK A8MYX0_HUMAN A8MYX0_HUMAN IKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIK B7ZB09_HUMAN B7ZB09_HUMAN IKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIK B4DPV3_HUMAN B4DPV3_HUMAN IKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIK DIAP3_HUMAN DIAP3_HUMAN IKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIK Q4R8N9_MACFA Q4R8N9_MACFA IKQMPEPEQLKMLSELKDEYDDLAESEQSGVVMGTVPRLRPRLNAILFKLQFSEQVENIK Q7KZJ7_HUMAN Q7KZJ7_HUMAN IKQMPEPEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIK A0RZB8_HUMAN A0RZB8_HUMAN IKQMPEPEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIK Q6URC4_HUMAN Q6URC4_HUMAN IKQMPEPEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIK B4DVR3_HUMAN B4DVR3_HUMAN IKQMPEPEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIK Q17RN4_HUMAN Q17RN4_HUMAN IKQMPEPEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIK DIAP1_HUMAN DIAP1_HUMAN IKQMPEPEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIK Q96IL1_HUMAN Q96IL1_HUMAN IKQMPEPEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIK Q05CS5_MOUSE Q05CS5_MOUSE ------------------------------------------------------------ DIAP1_MOUSE DIAP1_MOUSE IKQMPEPEQLKMLSELKEEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIK Q6NS79_MOUSE Q6NS79_MOUSE IKQMPEPEQLKMLSELKEEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIK Q3U104_MOUSE Q3U104_MOUSE IKQMPEPEQLKMLSELKEEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIK Q9DEH3_CHICK Q9DEH3_CHICK IKNLPEQKEINALAALQDEYNDLAESEQFIIVMSSVKLLRSRLNAILFKLSFEDHINNIK Q3U4Y4_MOUSE Q3U4Y4_MOUSE VKYLPDQNALRELAQLKSEYDDLCEPEQFGVVMSTVKMLRPRLTSILFKLTFEEHVNNIK Q6W4W7_MOUSE Q6W4W7_MOUSE VKYLPDQNALRELAQLKSEYDDLCEPEQFGVVMSTVKMLRPRLTSILFKLTFEEHVNNIK DIAP2_MOUSE DIAP2_MOUSE VKYLPDQNALRELAQLKSEYDDLCEPEQFGVVMSTVKMLRPRLTSILFKLTFEEHVNNIK A8MSQ4_HUMAN A8MSQ4_HUMAN VKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIK DIAP2_HUMAN DIAP2_HUMAN VKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIK B3KMJ1_HUMAN B3KMJ1_HUMAN VKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNTK A8K5F7_HUMAN A8K5F7_HUMAN VKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIK A6NML8_HUMAN A6NML8_HUMAN VKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIK B7ZLJ0_HUMAN B7ZLJ0_HUMAN VKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIK Q17R91_HUMAN Q17R91_HUMAN VKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIK MATCH CONSENSUS ?K??P????L??L??????Y??L?E?EQF?VVM??V??L?PRL??ILFKL?F?E???NIK

Q5DTM7_MOUSE Q5DTM7_MOUSE PDIMAVSTACEEIKKSKGFSKLLELVLLMGNYMNAGSRNAQTFGFDLSSLCKLKDTKSAD Q8K331_MOUSE Q8K331_MOUSE PDIMAVSTACEEIKKSKGFSKLLELVLLMGNYMNAGSRNAQTFGFDLSSLCKLKDTKSAD Q0VGT1_MOUSE Q0VGT1_MOUSE PDIMAVSTACEEIKKSKGFSKLLELVLLMGNYMNAGSRNAQTFGFDLSSLCKLKDTKSAD DIAP3_MOUSE DIAP3_MOUSE PDIMAVSTACEEIKKSKGFSKLLELVLLMGNYMNAGSRNAQTFGFDLSSLCKLKDTKSAD Q3TSX1_MOUSE Q3TSX1_MOUSE PDIMAVSTACEEIKKSKGFSKLLELVLLMGNYMNAGSRNAQTFGFDLSSLCKLKDTKSAD Q5PR81_MOUSE Q5PR81_MOUSE PDIMAVSTACEEIKKSKGFSKLLELVLLMGNYMNAGSRNAQTFGFDLSSLCKLKDTKSAD Q3UU77_MOUSE Q3UU77_MOUSE PDIMAVSTACEEIKKSKGFSKLLELVLLMGNYMNAGSRNAQTFGFDLSSLCKLKDTKSAD Q4R7E4_MACFA Q4R7E4_MACFA PDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSAD A6NG52_HUMAN A6NG52_HUMAN PDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSAD A8MYX0_HUMAN A8MYX0_HUMAN PDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSAD B7ZB09_HUMAN B7ZB09_HUMAN PDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSAD B4DPV3_HUMAN B4DPV3_HUMAN PDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSAD DIAP3_HUMAN DIAP3_HUMAN PDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSAD Q4R8N9_MACFA Q4R8N9_MACFA PEIVSVTAACEELRKSESFSSLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTD Q7KZJ7_HUMAN Q7KZJ7_HUMAN PEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTD A0RZB8_HUMAN A0RZB8_HUMAN PEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTD Q6URC4_HUMAN Q6URC4_HUMAN PEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTD B4DVR3_HUMAN B4DVR3_HUMAN PEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTD Q17RN4_HUMAN Q17RN4_HUMAN PEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTD DIAP1_HUMAN DIAP1_HUMAN PEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTD Q96IL1_HUMAN Q96IL1_HUMAN PEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTD Q05CS5_MOUSE Q05CS5_MOUSE ------------------------------------------------------------ DIAP1_MOUSE DIAP1_MOUSE PEIVSVTAACEELRKSENFSSLLELTLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSAD Q6NS79_MOUSE Q6NS79_MOUSE PEIVSVTAACEELRKSENFSSLLELTLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSAD Q3U104_MOUSE Q3U104_MOUSE PEIVSVTAACEELRKSENFSSLLELTLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSAD Q9DEH3_CHICK Q9DEH3_CHICK PGIMAVTRACEDLRKSESFSKLLELVLFLGNYMNTGSRNEQSLGFNITFLCKIIDTKSTD Q3U4Y4_MOUSE Q3U4Y4_MOUSE PSIIAVTLACEELKKSESFKRLLELILLVGNYMNSGSRNAQSLGFKINFLCKIKDTKSAD Q6W4W7_MOUSE Q6W4W7_MOUSE PSIIAVTLACEELKKSESFKRLLELILLVGNYMNSGSRNAQSLGFKINFLCKIKDTKSAD DIAP2_MOUSE DIAP2_MOUSE PSIIAVTLACEELKKSESFKRLLELILLVGNYMNSGSRNAQSLGFKINFLCKIKDTKSAD A8MSQ4_HUMAN A8MSQ4_HUMAN PSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSAD DIAP2_HUMAN DIAP2_HUMAN PSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSAD B3KMJ1_HUMAN B3KMJ1_HUMAN PSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSAD A8K5F7_HUMAN A8K5F7_HUMAN PSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSAD A6NML8_HUMAN A6NML8_HUMAN PSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSAD B7ZLJ0_HUMAN B7ZLJ0_HUMAN PSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSAD Q17R91_HUMAN Q17R91_HUMAN PSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSAD MATCH CONSENSUS P?I??V??ACEE??KS??F??LLE??LL?GNYMN?GSRNA???GF????LCK??DTKS?D

Q5DTM7_MOUSE Q5DTM7_MOUSE QKTTLLHFLVDVCEEKHADILHFVDDLAHLDKASRVSVEMLEKNVKQMGRQLQQLEKNLE Q8K331_MOUSE Q8K331_MOUSE QKTTLLHFLVDVCEEKHADILHFVDDLAHLDKASRVSVEMLEKNVKQMGRQLQQLEKNLE Q0VGT1_MOUSE Q0VGT1_MOUSE QKTTLLHFLVDVCEEKHADILHFVDDLAHLDKASRVSVEMLEKNVKQMGRQLQQLEKNLE DIAP3_MOUSE DIAP3_MOUSE QKTTLLHFLVDVCEEKHADILHFVDDLAHLDKASRVSVEMLEKNVKQMGRQLQQLEKNLE Q3TSX1_MOUSE Q3TSX1_MOUSE QKTTLLHFLVDVCEEKHADILHFVDDLAHLDKASRVSVEMLEKNVKQMGRQLQQLEKNLE Q5PR81_MOUSE Q5PR81_MOUSE QKTTLLHFLVDVCEEKHADILHFVDDLAHLDKASRVSVEMLEKNVKQMGRQLQQLEKNLE Q3UU77_MOUSE Q3UU77_MOUSE QKTTLLHFLVDVCEEKHADILHFVDDLAHLDKASRVSVEMLEKNVKQMGRQLQQLEKNLE Q4R7E4_MACFA Q4R7E4_MACFA QKTTLLHFLVEVCEEKYPDILNFVGDLEPLDKASNVSVEMLEKNLRQMGRQLQQLEKELE A6NG52_HUMAN A6NG52_HUMAN QKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKELE A8MYX0_HUMAN A8MYX0_HUMAN QKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKELE B7ZB09_HUMAN B7ZB09_HUMAN QKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASRVSVETLEKNLRQMGRQLQQLEKELE B4DPV3_HUMAN B4DPV3_HUMAN QKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKELE DIAP3_HUMAN DIAP3_HUMAN QKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKELE Q4R8N9_MACFA Q4R8N9_MACFA QKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQ Q7KZJ7_HUMAN Q7KZJ7_HUMAN QKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQ A0RZB8_HUMAN A0RZB8_HUMAN QKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQ Q6URC4_HUMAN Q6URC4_HUMAN QKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKRISDVERDVQ B4DVR3_HUMAN B4DVR3_HUMAN QKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQ Q17RN4_HUMAN Q17RN4_HUMAN QKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQ DIAP1_HUMAN DIAP1_HUMAN QKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQ Q96IL1_HUMAN Q96IL1_HUMAN QKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQ Q05CS5_MOUSE Q05CS5_MOUSE ------------------------------------------------------------ DIAP1_MOUSE DIAP1_MOUSE QKMTLLHFLAELCENDHPEVLKFPDELAHVEKASRVSAENLQKSLDQMKKQIADVERDVQ Q6NS79_MOUSE Q6NS79_MOUSE QKMTLLHFLAELCENDHPEVLKFPDELAHVEKASRVSAENLQKSLDQMKKQIADVERDVQ Q3U104_MOUSE Q3U104_MOUSE QKMTLLHFLAELCENDHPEVLKFPDELAHVEKASRVSAENLQKSLDQMKKQIADVERDVQ Q9DEH3_CHICK Q9DEH3_CHICK QKTTLLHFLAEVCEENYRDILKFTDDLQHVESASKVSDKTLKSNLDSMNKQIQRLESDIK Q3U4Y4_MOUSE Q3U4Y4_MOUSE QKSTLLHFLAEICDEKYRDILKFPDELEHVESAGKVSAQILKSNLVAMEQSILHLEKNIK Q6W4W7_MOUSE Q6W4W7_MOUSE QKSTLLHFLAEICDEKYRDILKFPDELEHVESAGKVSAQILKSNLVAMEQSILHLEKNIK DIAP2_MOUSE DIAP2_MOUSE QKSTLLHFLAEICDEKYRDILKFPDELEHVESAGKVSAQILKSNLVAMEQSILHLEKNIK A8MSQ4_HUMAN A8MSQ4_HUMAN QKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIK DIAP2_HUMAN DIAP2_HUMAN QKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIK B3KMJ1_HUMAN B3KMJ1_HUMAN QKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIK A8K5F7_HUMAN A8K5F7_HUMAN QKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIK A6NML8_HUMAN A6NML8_HUMAN QKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIK B7ZLJ0_HUMAN B7ZLJ0_HUMAN QKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIK Q17R91_HUMAN Q17R91_HUMAN QKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIK MATCH CONSENSUS QK?TLLHF????CE????D?L?F???L?H???AS?VS???L??N???M??Q????E????

Q5DTM7_MOUSE Q5DTM7_MOUSE TFPPPEDLHDKFVIKMS-SFVISANEQYEKLSTLLGSMTQLYQSVMGYYAVDMKKVSVEE Q8K331_MOUSE Q8K331_MOUSE TFPPPEDLHDKFVIKMS-SFVISANEQYEKLSTLLGSMTQLYQSIMGYYAVDMKKVSVEE Q0VGT1_MOUSE Q0VGT1_MOUSE TFPPPEDLHDKFVIKMS-SFVISANEQYEKLSTLLGSMTQLYQSIMGYYAVDMKKVSVEE DIAP3_MOUSE DIAP3_MOUSE TFPPPEDLHDKFVIKMS-SFVISANEQYEKLSTLLGSMTQLYQSIMGYYAVDMKKVSVEE Q3TSX1_MOUSE Q3TSX1_MOUSE TFPPPEDLHDKFVIKMS-SFVISANEQYEKLSTLLGSMTQLYQSIMGYYAVDMKKVSVEE Q5PR81_MOUSE Q5PR81_MOUSE TFPPPEDLHDKFVIKMS-SFVISANEQYEKLSTLLGSMTQLYQSIMGYYAVDMKKVSVEE Q3UU77_MOUSE Q3UU77_MOUSE TFPPPEDLHDKFVIKMS-SFVISANEQYEKLSTLLGSMTQLYQSIMGYYAVDMKKVSVEE Q4R7E4_MACFA Q4R7E4_MACFA TFPPPEDLHDKFVTKMS-RFVISAKEQYETVSKLHENMEKLYQSIMGYYAIDVKKVSVED A6NG52_HUMAN A6NG52_HUMAN TFPPPEDLHDKFVTKMS-IFVISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVED A8MYX0_HUMAN A8MYX0_HUMAN TFPPPEDLHDKFVTKMS-IFVISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVED B7ZB09_HUMAN B7ZB09_HUMAN TFPPPEDLHDKFVTKMS-RFVISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVED B4DPV3_HUMAN B4DPV3_HUMAN TFPPPEDLHDKFVTKMS-RFVISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVED DIAP3_HUMAN DIAP3_HUMAN TFPPPEDLHDKFVTKMS-RFVISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVED Q4R8N9_MACFA Q4R8N9_MACFA NFPAATDEKDKFVEKMT-SFVKDAQEQYNKLRMMHSNMETLYKELGDYFLFDPKKLSVEE Q7KZJ7_HUMAN Q7KZJ7_HUMAN NFPAATDEKDKFVEKMT-SFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEE A0RZB8_HUMAN A0RZB8_HUMAN NFPAATDEKDKFVEKMT-SFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEE Q6URC4_HUMAN Q6URC4_HUMAN NFPAATDEKDKFVEKMT-SFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEE B4DVR3_HUMAN B4DVR3_HUMAN NFPAATDEKDKFVEKMT-SFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEE Q17RN4_HUMAN Q17RN4_HUMAN NFPAATDEKDKFVEKMT-SFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEE DIAP1_HUMAN DIAP1_HUMAN NFPAATDEKDKFVEKMT-SFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEE Q96IL1_HUMAN Q96IL1_HUMAN NFPAATDEKDKFVEKMT-SFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEE Q05CS5_MOUSE Q05CS5_MOUSE --PPPPPIKDG-------SYKKKKKKKKKK------------------------------ DIAP1_MOUSE DIAP1_MOUSE NFPAATDEKDKFVEKMT-SFVKDAQEQYNKLRMMHSNMETLYKELGDYFVFDPKKLSVEE Q6NS79_MOUSE Q6NS79_MOUSE NFPAATDEKDKFVEKMT-SFVKDAQEQYNKLRMMHSNMETLYKELGDYFVFDPKKLSVEE Q3U104_MOUSE Q3U104_MOUSE NFPAATDEKDKFVEKMT-SFVKDAQEQYNKLRMMHSNMETLYKELGDYFVFDPKKLSVEE Q9DEH3_CHICK Q9DEH3_CHICK NFPKTEDEHDKFVEKMS-AFAENAREQYDKLSCMHNNMMKLYENLGEYFTFDAQSISIEE Q3U4Y4_MOUSE Q3U4Y4_MOUSE NFPPAESHHDKFVEKMMISFI--------------------------------------- Q6W4W7_MOUSE Q6W4W7_MOUSE NFPPAESHHDKFVEKMM-SFTQNAREQYDKLSTMHSNMLKLYESLGEYFIFDPNTVNMEE DIAP2_MOUSE DIAP2_MOUSE NFPPAESHHDKFVEKMM-SFTQNAREQYDKLSTMHSNMLKLYESLGEYFIFDPNTVNMEE A8MSQ4_HUMAN A8MSQ4_HUMAN KFPQAENQHDKFVEKMT-IFTKTAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEE DIAP2_HUMAN DIAP2_HUMAN KFPQAENQHDKFVEKMT-SFTKTAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEE B3KMJ1_HUMAN B3KMJ1_HUMAN KFPQAENQHDKFVEKMT-SFTKTAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEE A8K5F7_HUMAN A8K5F7_HUMAN KFPQAENQHDKFVEKMT-SFTKTAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEE A6NML8_HUMAN A6NML8_HUMAN KFPQAENQHDKFVEKMT-IFTKTAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEE B7ZLJ0_HUMAN B7ZLJ0_HUMAN KFPQAENQHDKFVEKMT-SFTKTAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEE Q17R91_HUMAN Q17R91_HUMAN KFPQAENQHDKFVEKMT-SFTKTAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEE MATCH * . :* : CONSENSUS ?FP??????DKFV?KM???F???A?EQY?KL??????M??LY?????Y???D?K??S?E?

Q5DTM7_MOUSE Q5DTM7_MOUSE FFNDLNNFRTSFMLALKENIKKREAAEKEKRARIAKERAEKERLERQQEKKRLLEMKTEG Q8K331_MOUSE Q8K331_MOUSE FFNDLNNFRTSFMLALKENIKKREAAEKEKRARIAKERAEKERLERQQEKKRLLEMKTEG Q0VGT1_MOUSE Q0VGT1_MOUSE FFNDLNNFRTSFMLALKENIKKREAAEKEKRARIAKERAEKERLERQQEKKRLLEMKTEG DIAP3_MOUSE DIAP3_MOUSE FFNDLNNFRTSFMLALKENIKKREAAEKEKRARIAKERAEKERLERQQEKKRLLEMKTEG Q3TSX1_MOUSE Q3TSX1_MOUSE FFNDLNNFRTSFMLALKENIKKREAAEKEKRARIA------------------------- Q5PR81_MOUSE Q5PR81_MOUSE FFNDLNNFRTSFMLALKENIKKREAAEKEKRARIAKERAEKERLERQQEKKRLLEMKTEG Q3UU77_MOUSE Q3UU77_MOUSE FFNDLNNFRTSFMLALKENIKKREAA---------------------------------- Q4R7E4_MACFA Q4R7E4_MACFA FLTDLNNFRTTFMQAIKENIKKREAEEKEKRARIAKELAERERLERQQKKKRLLEVKTEG A6NG52_HUMAN A6NG52_HUMAN FLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEG A8MYX0_HUMAN A8MYX0_HUMAN FLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEG B7ZB09_HUMAN B7ZB09_HUMAN FLTDLNNFRTTFMQAIKENI---------------------------------------- B4DPV3_HUMAN B4DPV3_HUMAN FLTDLNNFRTTFMQAIKENI---------------------------------------- DIAP3_HUMAN DIAP3_HUMAN FLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEG Q4R8N9_MACFA Q4R8N9_MACFA FFMDLHNFRNMFLQAVKENQKRRETEEKMRQAKLAKEKAEKELLLWPIPWRTLM----QG Q7KZJ7_HUMAN Q7KZJ7_HUMAN FFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEG A0RZB8_HUMAN A0RZB8_HUMAN FFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEG Q6URC4_HUMAN Q6URC4_HUMAN FFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEG B4DVR3_HUMAN B4DVR3_HUMAN FFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEG Q17RN4_HUMAN Q17RN4_HUMAN FFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEG DIAP1_HUMAN DIAP1_HUMAN FFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEG Q96IL1_HUMAN Q96IL1_HUMAN FFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEG Q05CS5_MOUSE Q05CS5_MOUSE ----------------KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK--------- DIAP1_MOUSE DIAP1_MOUSE FFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEG Q6NS79_MOUSE Q6NS79_MOUSE FFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEG Q3U104_MOUSE Q3U104_MOUSE FFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEG Q9DEH3_CHICK Q9DEH3_CHICK FFGDLNNFRILFLEALKENNKRREMEEKMRRAKQAREKAEQDRLERQKKKQRLLDMNKEG Q3U4Y4_MOUSE Q3U4Y4_MOUSE ------------------------------------------------------------ Q6W4W7_MOUSE Q6W4W7_MOUSE FFGDLNTFRTLFLEALKENHKRKEMEEKSRRAKLAKEKAEQEKLERQKKKKQLIDINKEG DIAP2_MOUSE DIAP2_MOUSE FFGDLNTFRTLFLEALKENHKRKEMEEKSRRAKLAKEKAEQEKLERQKKKKQLIDINKEG A8MSQ4_HUMAN A8MSQ4_HUMAN FFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKEKAEQEKLERQKKKKQLIDINKEG DIAP2_HUMAN DIAP2_HUMAN FFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKEKAEQEKLERQKKKKQLIDINKEG B3KMJ1_HUMAN B3KMJ1_HUMAN FFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKEKAEQEKLERQKKKKQLIDINKEG A8K5F7_HUMAN A8K5F7_HUMAN FFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKEKAEQEKLERQKKKKQLIDINKEG A6NML8_HUMAN A6NML8_HUMAN FFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKEKAEQEKLERQKKKKQLIDINKEG B7ZLJ0_HUMAN B7ZLJ0_HUMAN FFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKEKAEQEKLERQKKKKQLIDINKEG Q17R91_HUMAN Q17R91_HUMAN FFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKEKAEQEKLERQKKKKQLIDINKEG MATCH CONSENSUS F??DL?NFR??F??A??EN?K?RE??EK??R???AKE?AE?E?LE?Q?????L?????EG

Q5DTM7_MOUSE Q5DTM7_MOUSE DETGVMDSLLEALQSGAAFRDRRKRTPKLKDIRQSLSPMSQRPVLKVCNHENQKMQLTEG Q8K331_MOUSE Q8K331_MOUSE DETGVMDSLLEALQSGAAFRDRRKRTPKLKDIRQSLSPMSQRPVLKVCNHENQKMQLTEG Q0VGT1_MOUSE Q0VGT1_MOUSE DETGVMDSLLEALQSGAAFRDRRKRTPKLKDIRQSLSPMSQRPVLKVCNHENQKMQLTEG DIAP3_MOUSE DIAP3_MOUSE DETGVMDSLLEALQSGAAFRDRRKRTPKLKDIRQSLSPMSQRPVLKVCNHENQKMQLTEG Q3TSX1_MOUSE Q3TSX1_MOUSE ------------------------------------------------------------ Q5PR81_MOUSE Q5PR81_MOUSE DETGVMDSLLEALQSGAAFRDRRKRTPKLKDIRQSLSPMSQRPVLKVCNHENQKMQLTEG Q3UU77_MOUSE Q3UU77_MOUSE ------------------------------------------------------------ Q4R7E4_MACFA Q4R7E4_MACFA DETGVMDNLLEALQSGAAFRDRRKRTPMPKDVRQSLSPMSQRPVLKVCNHGNKPYL---- A6NG52_HUMAN A6NG52_HUMAN DETGVMDNLLEALQSGAAFRDRRKRTPMPKDVRQSLSPMSQRPVLKVCNHGNKPYL---- A8MYX0_HUMAN A8MYX0_HUMAN DETGVMDNLLEALQSGAAFRDRRKRTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEG B7ZB09_HUMAN B7ZB09_HUMAN ------------------------------------------------------------ B4DPV3_HUMAN B4DPV3_HUMAN ------------------------------------------------------------ DIAP3_HUMAN DIAP3_HUMAN DETGVMDNLLEALQSGAAFRDRRKRTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEG Q4R8N9_MACFA Q4R8N9_MACFA VCCSAESPPPCSLTSG---------------------ALTLSFLIYFC------------ Q7KZJ7_HUMAN Q7KZJ7_HUMAN DETGVMDSLLEALQSGAAF--RRKRGPRQANRKA---GCAVTSLLASELTKDDAMAAVPA A0RZB8_HUMAN A0RZB8_HUMAN DETGVMDSLLEALQSGAAF--RRKRGPRQANRKA---GCAVTSLLASELTKDDAMAAVPA Q6URC4_HUMAN Q6URC4_HUMAN DETGVMDSLLEALQSGAAF--RRKRGPRQANRKA---GCAVTSLLASELTKDDAMAAVPA B4DVR3_HUMAN B4DVR3_HUMAN DETGVMDSLLEALQSGAAF--RRKRGPRQANRKA---GCAVTSLLASELTKDDAMAAVPA Q17RN4_HUMAN Q17RN4_HUMAN DETGVMDSLLEALQSGAAF--RRKRGPRQANRKA---GCAVTSLLASELTKDDAMAAVPA DIAP1_HUMAN DIAP1_HUMAN DETGVMDSLLEALQSGAAF--RRKRGPRQANRKA---GCAVTSLLASELTKDDAMAAVPA Q96IL1_HUMAN Q96IL1_HUMAN DETGVMDSLLEALQSGAAF--RRKRGPRQANRKA---GCAVTSLLASELTKDDAMAAVPA Q05CS5_MOUSE Q05CS5_MOUSE ------------------------------------------------------------ DIAP1_MOUSE DIAP1_MOUSE DETGVMDSLLEALQSGAAF--RRKRGPRQVNRKA---GCAVTSLLASELTKDDAMAPGPV Q6NS79_MOUSE Q6NS79_MOUSE DETGVMDSLLEALQSGAAF--RRKRGPRQVNRKA---GCAVTSLLASELTKDDAMAPGPV Q3U104_MOUSE Q3U104_MOUSE DETGVMDSLLEALQSGAAF--RRKRGPRQVNRKA---GCAVTSLLASELTKDDAMAPGPV Q9DEH3_CHICK Q9DEH3_CHICK DETGVMDSLLEALQSGAAFRDRRKRVPR--DNRQ---VCLEDSRTRHSGTRPAL------ Q3U4Y4_MOUSE Q3U4Y4_MOUSE ------------------------------------------------------------ Q6W4W7_MOUSE Q6W4W7_MOUSE DETGVMDNLLEALQSGAAFRDRRKRIPRNPDNRR---PPLERSRSRHNGAMSSK------ DIAP2_MOUSE DIAP2_MOUSE DETGVMDNLLEALQSGAAFRDRRKRIPRNPDNRR---PPLERSRSRHNGAMSSK------ A8MSQ4_HUMAN A8MSQ4_HUMAN DETGVMDNLLEALQSGAAFRDRRKRIPRNPDNRR---VPLERSRSRHNGAISSK------ DIAP2_HUMAN DIAP2_HUMAN DETGVMDNLLEALQSGAAFRDRRKRIPRNPDNRR---VPLERSRSRHNGAISSK------ B3KMJ1_HUMAN B3KMJ1_HUMAN DETGVMDNLLEALQSGAAFRDRRKRIPRNPVVNH---PCATRANPRSAT----------- A8K5F7_HUMAN A8K5F7_HUMAN DETGVMDNLLEALQSGAAFRDRRKRIPRNPVVNH---PCATRANPRSAT----------- A6NML8_HUMAN A6NML8_HUMAN DETGVMDNLLEALQSGAAFRDRRKRIPRNPVVNH---PCATRANPRSAT----------- B7ZLJ0_HUMAN B7ZLJ0_HUMAN DETGVMDNLLEALQSGAAFRDRRKRIPRNPVVNH---PCATRANPRSAT----------- Q17R91_HUMAN Q17R91_HUMAN DETGVMDNLLEALQSGAAFRDRRKRIPRNPVVNH---PCATRANPRSAT----------- MATCH CONSENSUS DETGVMD?LLEALQSGAAF??RRKR?P?????????????????????????????????

Q5DTM7_MOUSE Q5DTM7_MOUSE SRPHHSINCNSTRTPVAKELNYNLDTHASTGRIKAVE-KEACNAESNRKKEMELLGSVAK Q8K331_MOUSE Q8K331_MOUSE SRPHHSINCNSTRTPVAKELNYNLDTHASTGRIKAVE-KEACNAESNRKKEMELLGSVAK Q0VGT1_MOUSE Q0VGT1_MOUSE SRPHHSINCNSTRTPVAKELNYNLDTHASTGRIKAVE-KEACNAESNKKKEMELLGSVAK DIAP3_MOUSE DIAP3_MOUSE SRPHHSINCNSTRTPVAKELNYNLDTHASTGRIKAVE-KEACNAESNKKKEMELLGSVAK Q3TSX1_MOUSE Q3TSX1_MOUSE ------------------------------------------------------------ Q5PR81_MOUSE Q5PR81_MOUSE SRPHHSINCNSTRTPVAKELNYNLDTHASTGRIKAVE-KEACNAESNKKKKKK------- Q3UU77_MOUSE Q3UU77_MOUSE ------------------------------------------------------------ Q4R7E4_MACFA Q4R7E4_MACFA ------------------------------------------------------------ A6NG52_HUMAN A6NG52_HUMAN ------------------------------------------------------------ A8MYX0_HUMAN A8MYX0_HUMAN SRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVESNRKKETELLGSFSK B7ZB09_HUMAN B7ZB09_HUMAN ------------------------------------------------------------ B4DPV3_HUMAN B4DPV3_HUMAN ------------------------------------------------------------ DIAP3_HUMAN DIAP3_HUMAN SRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVESNRKKETELLGSFSK Q4R8N9_MACFA Q4R8N9_MACFA ------------------------------------------------------------ Q7KZJ7_HUMAN Q7KZJ7_HUMAN KVSKNSETFPTILEEAKELVGRAS------------------------------------ A0RZB8_HUMAN A0RZB8_HUMAN KVPKNSETFPTILEEAKELVGRAS------------------------------------ Q6URC4_HUMAN Q6URC4_HUMAN KVSKNSETFPTILEEAKELVGRAS------------------------------------ B4DVR3_HUMAN B4DVR3_HUMAN KVSKNSETFPTILEEAKELVGRAS------------------------------------ Q17RN4_HUMAN Q17RN4_HUMAN KVSKNSETFPTILEEAKELVGRAS------------------------------------ DIAP1_HUMAN DIAP1_HUMAN KVSKNSETFPTILEEAKELVGRAS------------------------------------ Q96IL1_HUMAN Q96IL1_HUMAN KVSKNSETFPTILEEAKELVGRAS------------------------------------ Q05CS5_MOUSE Q05CS5_MOUSE ------------------------------------------------------------ DIAP1_MOUSE DIAP1_MOUSE KVPKKSEGVPTILEEAKELVGRAS------------------------------------ Q6NS79_MOUSE Q6NS79_MOUSE KVPKKSEGVPTILEEAKELVGRAS------------------------------------ Q3U104_MOUSE Q3U104_MOUSE KVPKKSEGVPTILEEAKELVGRAS------------------------------------ Q9DEH3_CHICK Q9DEH3_CHICK ------------------------------------------------------------ Q3U4Y4_MOUSE Q3U4Y4_MOUSE ------------------------------------------------------------ Q6W4W7_MOUSE Q6W4W7_MOUSE ------------------------------------------------------------ DIAP2_MOUSE DIAP2_MOUSE ------------------------------------------------------------ A8MSQ4_HUMAN A8MSQ4_HUMAN ------------------------------------------------------------ DIAP2_HUMAN DIAP2_HUMAN ------------------------------------------------------------ B3KMJ1_HUMAN B3KMJ1_HUMAN ------------------------------------------------------------ A8K5F7_HUMAN A8K5F7_HUMAN ------------------------------------------------------------ A6NML8_HUMAN A6NML8_HUMAN ------------------------------------------------------------ B7ZLJ0_HUMAN B7ZLJ0_HUMAN ------------------------------------------------------------ Q17R91_HUMAN Q17R91_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5DTM7_MOUSE Q5DTM7_MOUSE SESVPEVEALLARLRAL Q8K331_MOUSE Q8K331_MOUSE SESVPEVEALLARLRAL Q0VGT1_MOUSE Q0VGT1_MOUSE SESVPEVEALLARLRAL DIAP3_MOUSE DIAP3_MOUSE SESVPEVEALLARLRAL Q3TSX1_MOUSE Q3TSX1_MOUSE ----------------- Q5PR81_MOUSE Q5PR81_MOUSE ----------------- Q3UU77_MOUSE Q3UU77_MOUSE ----------------- Q4R7E4_MACFA Q4R7E4_MACFA ----------------- A6NG52_HUMAN A6NG52_HUMAN ----------------- A8MYX0_HUMAN A8MYX0_HUMAN NESVPEVEALLARLRAL B7ZB09_HUMAN B7ZB09_HUMAN ----------------- B4DPV3_HUMAN B4DPV3_HUMAN ----------------- DIAP3_HUMAN DIAP3_HUMAN NESVPEVEALLARLRAL Q4R8N9_MACFA Q4R8N9_MACFA ----------------- Q7KZJ7_HUMAN Q7KZJ7_HUMAN ----------------- A0RZB8_HUMAN A0RZB8_HUMAN ----------------- Q6URC4_HUMAN Q6URC4_HUMAN ----------------- B4DVR3_HUMAN B4DVR3_HUMAN ----------------- Q17RN4_HUMAN Q17RN4_HUMAN ----------------- DIAP1_HUMAN DIAP1_HUMAN ----------------- Q96IL1_HUMAN Q96IL1_HUMAN ----------------- Q05CS5_MOUSE Q05CS5_MOUSE ----------------- DIAP1_MOUSE DIAP1_MOUSE ----------------- Q6NS79_MOUSE Q6NS79_MOUSE ----------------- Q3U104_MOUSE Q3U104_MOUSE ----------------- Q9DEH3_CHICK Q9DEH3_CHICK ----------------- Q3U4Y4_MOUSE Q3U4Y4_MOUSE ----------------- Q6W4W7_MOUSE Q6W4W7_MOUSE ----------------- DIAP2_MOUSE DIAP2_MOUSE ----------------- A8MSQ4_HUMAN A8MSQ4_HUMAN ----------------- DIAP2_HUMAN DIAP2_HUMAN ----------------- B3KMJ1_HUMAN B3KMJ1_HUMAN ----------------- A8K5F7_HUMAN A8K5F7_HUMAN ----------------- A6NML8_HUMAN A6NML8_HUMAN ----------------- B7ZLJ0_HUMAN B7ZLJ0_HUMAN ----------------- Q17R91_HUMAN Q17R91_HUMAN ----------------- MATCH CONSENSUS ?????????????????


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