Alignment of the gene Family HBG051498 of HOVERGEN

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Threshold: 50% 80% 100%
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Isoforms are ON
Q66II2_XENTR Q66II2_XENTR ------------MKLNIDGLLVYFPYEYIYPEQYSYMLELKRTLDAKGHGVLEMPSGTGK ERCC2_CRIGR ERCC2_CRIGR ------------MKLNVDGLLVYFPYDYIYPEQFSYMLELKRTLDAKGHGVLEMPSGTGK Q8K223_MOUSE Q8K223_MOUSE ------------MKLNVDGLLVYFPYDYIYPEQFSYMLELKRTLDAKGHGVLEMPSGTGK Q3UKK7_MOUSE Q3UKK7_MOUSE ------------MKLNVDGLLVYFPYDYIYPEQFSYMLELKRTLDAKGHGVLEMPSGTGK ERCC2_MOUSE ERCC2_MOUSE ------------MKLNVDGLLVYFPYDYIYPEQFSYMLELKRTLDAKGHGVLEMPSGTGK Q8C487_MOUSE Q8C487_MOUSE ------------MKLNVDGLLVYFPYDYIYPEQFSYMLELKRTLDAKGHGVLEMPSGTGK A1L590_BOVIN A1L590_BOVIN CKVRGGPHRAPASRLNVDGLLVYFPYDYIYPEQFSYMLELKRTLDAKGHGVLEMPSGTGK ERCC2_BOVIN ERCC2_BOVIN ------------MKLNVDGLLVYFPYDYIYPEQFSYMLELKRTLDAKGHGVLEMPSGTGK A5A791_PIG A5A791_PIG ----------------VDGLLVYFPYDYIYPEQFSYMLELKRTLDAKGHGVLEMPSGTGK Q2TB79_HUMAN Q2TB79_HUMAN ------------MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGK A8MX75_HUMAN A8MX75_HUMAN ------------MR------------------------ELKRTLDAK------------- ERCC2_HUMAN ERCC2_HUMAN ------------MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGK Q2TB78_HUMAN Q2TB78_HUMAN ------------MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGK Q7ZWH2_DANRE Q7ZWH2_DANRE ------------MKLNIDGLLVYFPYDYIYPEQYSYMLELKRTLDAKGHGVLEMPSGTGK B5X1K2_SALSA B5X1K2_SALSA ------------MKLNIEGLLVYFPYDYIYPEQYSYMLELKRTLDAKGHGVLEMPSGTGK Q91941_XIPMA Q91941_XIPMA ------------MKLNIEGLLVYFPYDYIYPEQYSYMLELKRTLDAKGHGVLEMPSGTGK MATCH ********* CONSENSUS ????????????MKLN?DGLLVYFPYDYIYPEQ?SYM?ELKRTLDAKGHGVLEMPSGTGK

Q66II2_XENTR Q66II2_XENTR TVSLLSLIVAYQRAYPLEVTKLIYCSRTVPEIEKVVEELRKLIEYTQAQTGGTLNFMALA ERCC2_CRIGR ERCC2_CRIGR TVSLLALIVAYQRAFPLEVTKLIYCSRTVPEIEKVIEELRKLLSFYEQQEGEKLPFLGLA Q8K223_MOUSE Q8K223_MOUSE TVSLLALIVAYQR---------------------VIEELRKLLSFYEQQEGEKLPFLGLA Q3UKK7_MOUSE Q3UKK7_MOUSE TVSLLALIVAYQRAYPLEVTKLIYCSRTVPEIEKVIEERRKLLSFYEQQEGEKLPFLGLA ERCC2_MOUSE ERCC2_MOUSE TVSLLALIVAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLSFYEQQEGEKLPFLGLA Q8C487_MOUSE Q8C487_MOUSE TVSLLALIVAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLSFYEQQEGEKLPFLGLA A1L590_BOVIN A1L590_BOVIN TVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLSFYEKQEGEKLPFLGLA ERCC2_BOVIN ERCC2_BOVIN TVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLSFYEKQEGEKLPFLGLA A5A791_PIG A5A791_PIG TVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLSFYEKQEGEKLPFLGLA Q2TB79_HUMAN Q2TB79_HUMAN TVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLA A8MX75_HUMAN A8MX75_HUMAN -------------AYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLA ERCC2_HUMAN ERCC2_HUMAN TVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLA Q2TB78_HUMAN Q2TB78_HUMAN TVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLA Q7ZWH2_DANRE Q7ZWH2_DANRE TISLLSLIVAYQKTYPLEVTKLVYCSRTVPEIEKVVEELRKLMDYYSKQTGVKNDFLALA B5X1K2_SALSA B5X1K2_SALSA TISLLSLIVAYQREYPLEVTKLIYCSRTVPEIEKVVEELRKLMEFYSKETGEKNNILALA Q91941_XIPMA Q91941_XIPMA TISLLSLIVAYQRAFPLDVTKLIYCSRTVPEIEKVVEELRKLMEFYAKETGEVNNFLALS MATCH *:** ***:.: : * ::.*: CONSENSUS T?SLL?LI?AYQRAYPLEVTKLIYCSRTVPEIEKV?EELRKL??FY??Q?GEKL?FL?LA

Q66II2_XENTR Q66II2_XENTR LSSRRNLCVNPEVSALRFGKEIDGRCHSLTASFVRSQKQRDPTVQTCRFFEEFDAIGRET ERCC2_CRIGR ERCC2_CRIGR LSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQQDASLPHCRFYEEFDAHGRQV Q8K223_MOUSE Q8K223_MOUSE LSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQQDASLPHCRFYEEFDIHGRQM Q3UKK7_MOUSE Q3UKK7_MOUSE LSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQQDASLPHCRFYEEFDIHGRQM ERCC2_MOUSE ERCC2_MOUSE LSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQQDASLPHCRFYEEFDIHGRQM Q8C487_MOUSE Q8C487_MOUSE LSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQQDASLPHCRFYEEFDIHGRQM A1L590_BOVIN A1L590_BOVIN LSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQRDSSLPHCRFYEEFDVHGRQV ERCC2_BOVIN ERCC2_BOVIN LSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQRDSSLPHCRFYEEFDVHGRQV A5A791_PIG A5A791_PIG LSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQQDPSLPHCRFYEEFDVHGRQV Q2TB79_HUMAN Q2TB79_HUMAN LSSRKNLCIHPE------------------------------------------------ A8MX75_HUMAN A8MX75_HUMAN LSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREV ERCC2_HUMAN ERCC2_HUMAN LSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREV Q2TB78_HUMAN Q2TB78_HUMAN LSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREV Q7ZWH2_DANRE Q7ZWH2_DANRE LSSRKNLCIHPEVSSLRFGKEVDGKCHSLTASYIRAQHQSNPNQPVCQFYEEFDNVGRQV B5X1K2_SALSA B5X1K2_SALSA LSSRKNLCVHPEVSSLRFGKEVDGKCHSLTASYIRAQRQSNPSLPSCRFYEEFDAMGKQV Q91941_XIPMA Q91941_XIPMA LSSRKNLCIHPEVSSLRFGKEVDGKCHSLTASYIRAQRHSNPNQPVCRFYEEFDAVGRQV MATCH ****:***::** CONSENSUS LSSRKNLCIHPEV??LRFGK?VDGKCHSLTASY?RAQ?Q?????P?CRFYEEFD??GR??

Q66II2_XENTR Q66II2_XENTR PLPPGIYNLDDLRTLGRQKGWCPYYLARHALGQCNVVVYSYHYLLDPKIADLVSRELSKK ERCC2_CRIGR ERCC2_CRIGR PLPAGIYNLDDLKALGQRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARK Q8K223_MOUSE Q8K223_MOUSE PLPAGIYNLDDLKALGHRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARK Q3UKK7_MOUSE Q3UKK7_MOUSE PLPAGIYNLDDLKALGQRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARK ERCC2_MOUSE ERCC2_MOUSE PLPAGIYNLDDLKALGQRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARK Q8C487_MOUSE Q8C487_MOUSE PLPAGIYNLDDLKALGQRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARK A1L590_BOVIN A1L590_BOVIN PLPTGIYNLDDLKAVGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARK ERCC2_BOVIN ERCC2_BOVIN PLPTGIYNLDDLKAVGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARK A5A791_PIG A5A791_PIG PLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARK Q2TB79_HUMAN Q2TB79_HUMAN ------------------------------ILHANVVVYSYHYLLDPKIADLVSKELARK A8MX75_HUMAN A8MX75_HUMAN PLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARK ERCC2_HUMAN ERCC2_HUMAN PLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARK Q2TB78_HUMAN Q2TB78_HUMAN PLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARK Q7ZWH2_DANRE Q7ZWH2_DANRE PIPPGIYNLDDLKDFGRRKGWCPYFLARYALLHANIVVYSYHYLLDPKIADLVSKELAKK B5X1K2_SALSA B5X1K2_SALSA PLPAGVYNLDDLKDFGRRKGWCPYYLARYSILHANIIVYSYHYLLDPKIADLVSKELSKK Q91941_XIPMA Q91941_XIPMA PLPAGIYNLDDLKDFGRRKGWCPYYLARYSILHANIVVYSYHYLLDPKIADLVSKELAKK MATCH : :.*::*****************:**::* CONSENSUS PLP?GIYNLDDLK??G?R?GWCPY?LARYSILHANVVVYSYHYLLDPKIADLVSKELA?K

Q66II2_XENTR Q66II2_XENTR SVVVFDEAHNIDNVCIDSMSVTITRRTLERCQTNIETLNTAIEKIKETDEKKLKEEYAQL ERCC2_CRIGR ERCC2_CRIGR AVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQSNLDTLQKTVLRIKETDEQRLRDEYRRL Q8K223_MOUSE Q8K223_MOUSE AVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQSNLDTLQKTVLRIKETDEQRLRDEYRRL Q3UKK7_MOUSE Q3UKK7_MOUSE AVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQSNLDTLQKTVLRIKETDEQRLRDEYRRL ERCC2_MOUSE ERCC2_MOUSE AVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQSNLDTLQKTVLRIKETDEQRLRDEYRRL Q8C487_MOUSE Q8C487_MOUSE AVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQSNLDTLQKTVLRIKETDEQRLRDEYRRL A1L590_BOVIN A1L590_BOVIN AVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQANLETLQKTVLRIKETDEQRLREEYRRL ERCC2_BOVIN ERCC2_BOVIN AVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQANLETLQKTVLRIKETDEQRLREEYRRL A5A791_PIG A5A791_PIG AVVVFDEAHNIDNVCIDSMSVNLTRRMLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRL Q2TB79_HUMAN Q2TB79_HUMAN AVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRL A8MX75_HUMAN A8MX75_HUMAN AVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRL ERCC2_HUMAN ERCC2_HUMAN AVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRL Q2TB78_HUMAN Q2TB78_HUMAN AVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRL Q7ZWH2_DANRE Q7ZWH2_DANRE SVVVFDEAHNIDNVCIDSMSVNITRRTLDRCQTNVETLQNTISRIKETDAAKLREEYRRL B5X1K2_SALSA B5X1K2_SALSA SVVVFDEAHNIDNVCIDSMSVNITRRTLDRSQANVETLQNTILKIKETDAAKLKEEYRRL Q91941_XIPMA Q91941_XIPMA SVVVFDEAHNIDNVCIDSMSVNITRRTVDRCQNNVDTLQNTIHKIKETDAAKLREEYRRL MATCH :********************.:*** ::*.* *::**:.:: :***** :*::** :* CONSENSUS ?VVVFDEAHNIDNVCIDSMSVN?TRRTLDRCQ?N??TLQ?T?LRIKETDE??LR?EYRRL

Q66II2_XENTR Q66II2_XENTR VEGLREASVARETDVYLSNPVLPDEILQEAVPGCIRNALHFLGFLRRLVGYIKSRLRAGH ERCC2_CRIGR ERCC2_CRIGR VEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQH Q8K223_MOUSE Q8K223_MOUSE VEGLREASVARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQH Q3UKK7_MOUSE Q3UKK7_MOUSE VEGLREASVARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQH ERCC2_MOUSE ERCC2_MOUSE VEGLREASVARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQH Q8C487_MOUSE Q8C487_MOUSE VEGLREASVARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQH A1L590_BOVIN A1L590_BOVIN VEGLREASAARETDAHLANPVLPDEVLKEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQH ERCC2_BOVIN ERCC2_BOVIN VEGLREASAARETDAHLANPVLPDEVLKEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQH A5A791_PIG A5A791_PIG VEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQH Q2TB79_HUMAN Q2TB79_HUMAN VEGLREASAARETDAHLANPVLPNEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQH A8MX75_HUMAN A8MX75_HUMAN VEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQH ERCC2_HUMAN ERCC2_HUMAN VEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQH Q2TB78_HUMAN Q2TB78_HUMAN VEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQH Q7ZWH2_DANRE Q7ZWH2_DANRE VEGLKEANVARETDIYLSNPVLPDEILQEAVPGSIRTAEHFVGFMKRFLEYLKARLRIHH B5X1K2_SALSA B5X1K2_SALSA VEGLKEANVARETDIYMSNPVLPDEILQEAVPGSIRTAEHFVGFMKRFLEYLKARLRIHH Q91941_XIPMA Q91941_XIPMA VEGLKEANVARETDIYLANPVLPDEVLQEAVPGSIRTAEHFVGFLRRFLEYLKARLRVQH MATCH ****:**..***** :::*****:*:*:*****.**.* **:**::*:: *:* *** * CONSENSUS VEGLREAS?ARETD??LANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEY?K?RLRVQH

Q66II2_XENTR Q66II2_XENTR VTQEGPAAFLRDLYEKVCIERKPMRFCAERLRSLTRTLEIADITDLSPLTLITNFATLVS ERCC2_CRIGR ERCC2_CRIGR VVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEIADLADFSPLTLLANFATLVS Q8K223_MOUSE Q8K223_MOUSE VVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEIADLADFSPLTLLANFATLVS Q3UKK7_MOUSE Q3UKK7_MOUSE VVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEIADLADFSPLTLLANFATLVS ERCC2_MOUSE ERCC2_MOUSE VVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEIADLADFSPLTLLANFATLVS Q8C487_MOUSE Q8C487_MOUSE VVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEIADLADFSPLTLLANFATLVS A1L590_BOVIN A1L590_BOVIN VVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLYTLEISDLTDFSPLTLLANFATLVS ERCC2_BOVIN ERCC2_BOVIN VVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLYTLEISDLTDFSPLTLLANFATLVS A5A791_PIG A5A791_PIG VVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEIADLADFSPLTLLANFATLVS Q2TB79_HUMAN Q2TB79_HUMAN VVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVS A8MX75_HUMAN A8MX75_HUMAN VVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVS ERCC2_HUMAN ERCC2_HUMAN VVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVS Q2TB78_HUMAN Q2TB78_HUMAN VVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVS Q7ZWH2_DANRE Q7ZWH2_DANRE VVQESAPQFLKDIFEKVCIDRKPLRFCAERLRSLLRTLEIADIADFSPITLISHFATLVS B5X1K2_SALSA B5X1K2_SALSA VVQESAPQFLKDIFEKVCIDRKPLRFCAERLRSLLRTLEIADIADFSAITLISNFATLVS Q91941_XIPMA Q91941_XIPMA VVQESAPQFLKDIFDKVCIDRKPLRFCAERLQCLLRTLEIADIADFSAVTLISNFATLVS MATCH *.**... ** .: ::***:***:*******:.* ****:*::*:*.:**:::****** CONSENSUS VVQESPPAFL??L???VCI?RKPLRFCAERLRSLL?TLEI?D?ADFSPLTL??NFATLVS

Q66II2_XENTR Q66II2_XENTR TYTKGFMIIIEPFEDRTPSISNPVLHFSCLDSSLAIKPVFQRFQSVIITSGTLSPLDIYP ERCC2_CRIGR ERCC2_CRIGR TYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYP Q8K223_MOUSE Q8K223_MOUSE TYAKGFTIIIEPFDDRTPTIANPVLHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYP Q3UKK7_MOUSE Q3UKK7_MOUSE TYAKGFTIIIEPFDDRTPTIANPVLHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYP ERCC2_MOUSE ERCC2_MOUSE TYAKGFTIIIEPFDDRTPTIANPVLHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYP Q8C487_MOUSE Q8C487_MOUSE TYAKGFTIIIEPFDDRTPTIANPVLHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYP A1L590_BOVIN A1L590_BOVIN TYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYP ERCC2_BOVIN ERCC2_BOVIN TYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYP A5A791_PIG A5A791_PIG TYAKGFTIIIEPFDDRTPTIANPVLHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYP Q2TB79_HUMAN Q2TB79_HUMAN TYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYP A8MX75_HUMAN A8MX75_HUMAN TYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYP ERCC2_HUMAN ERCC2_HUMAN TYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYP Q2TB78_HUMAN Q2TB78_HUMAN TYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYP Q7ZWH2_DANRE Q7ZWH2_DANRE TYSKGFTIIIEPFEDKTPTIANPVLHFSCMDPSIAIKPVFGRFQTVIITSGTLSPLDIYP B5X1K2_SALSA B5X1K2_SALSA TYSKGFTIIIEPFEDRTPTIANPVLHFSCMDPSIAIKPVFERFQSVIITSGTLSPLDIYP Q91941_XIPMA Q91941_XIPMA TYSQGFTIIIEPFEDRTPTIANPVLHFSCMDPSIAIKPVFQRFQSVIITSGTLSPLDIYP MATCH **::** ******:*:**:*:**:*****:*.*:****** ***:*************** CONSENSUS TY?KGFTIIIEPF?DRTPTIANP?LHFSCMD?SLAIKPVFERFQSVIITSGTLSPLDIYP

Q66II2_XENTR Q66II2_XENTR KILDFRPVTMATFTMTLARVCLCPMVVGRGNDQVAMSSKFETREDLAVMRNYGNLLLEMS ERCC2_CRIGR ERCC2_CRIGR KILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMS Q8K223_MOUSE Q8K223_MOUSE KILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMS Q3UKK7_MOUSE Q3UKK7_MOUSE KILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMS ERCC2_MOUSE ERCC2_MOUSE KILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMS Q8C487_MOUSE Q8C487_MOUSE KILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMS A1L590_BOVIN A1L590_BOVIN KILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMS ERCC2_BOVIN ERCC2_BOVIN KILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMS A5A791_PIG A5A791_PIG KILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMS Q2TB79_HUMAN Q2TB79_HUMAN KILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMS A8MX75_HUMAN A8MX75_HUMAN KILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMS ERCC2_HUMAN ERCC2_HUMAN KILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMS Q2TB78_HUMAN Q2TB78_HUMAN KILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMS Q7ZWH2_DANRE Q7ZWH2_DANRE RILDFRPVTMASFTMTLARTCLCPLIVGRGNDQVAMTSKFETREDFAVIRNYGNLLLEMS B5X1K2_SALSA B5X1K2_SALSA RILDFRPVTVASFTMTLARTCLCPLVVGRGNDQVAMTSKFETREDFAVIRNYGNLLLEMS Q91941_XIPMA Q91941_XIPMA RILDFRPVTMASFTMTLARTCLCPLIVGRGNDQVALSSKFETREDFAVIRNYGNLLLEMS MATCH :****:***:*:*******.****:::********::********:**:*********** CONSENSUS KILDF?PVTMATFTMTLARVCLCPMI?GRGNDQVA?SSKFETRED?AVIRNYGNLLLEMS

Q66II2_XENTR Q66II2_XENTR AVVPDGIVGFFTSYLYMENIVASWYEQGILENIQRNKLIFIETQDGAETSVALEKYQEAC ERCC2_CRIGR ERCC2_CRIGR AVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEAC Q8K223_MOUSE Q8K223_MOUSE AVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEAC Q3UKK7_MOUSE Q3UKK7_MOUSE AVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEAC ERCC2_MOUSE ERCC2_MOUSE AVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEAC Q8C487_MOUSE Q8C487_MOUSE AVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEAC A1L590_BOVIN A1L590_BOVIN AVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEAC ERCC2_BOVIN ERCC2_BOVIN AVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEAC A5A791_PIG A5A791_PIG AVVPDGIVAFFTSYQYMESTVAAWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEAC Q2TB79_HUMAN Q2TB79_HUMAN AVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEAC A8MX75_HUMAN A8MX75_HUMAN AVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEAC ERCC2_HUMAN ERCC2_HUMAN AVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEAC Q2TB78_HUMAN Q2TB78_HUMAN AVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEAC Q7ZWH2_DANRE Q7ZWH2_DANRE AIVPDGIVAFFTSYMYMENIVASWYEQGILENIQRNKLIFIETQDAAETSMALEKYQEAC B5X1K2_SALSA B5X1K2_SALSA AIVPDGIVAFFTSYTYMENIVASWYEQGILENVQRNKLIFIETPDAAETSMALEKYQEAC Q91941_XIPMA Q91941_XIPMA AVVPDGIVAFFTSYVYMENIVASWYEQGILENIQKNKLIFIETQDAAETSMALEKYQEAC MATCH *:******.***** ***. **:*********:*:***:**** *.****:********* CONSENSUS AVVPDGIVAFFTSY?YME??VASWYEQGILENIQRNKL?FIETQDGAETSVALEKYQEAC

Q66II2_XENTR Q66II2_XENTR ENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLQFLRDQFHLRE ERCC2_CRIGR ERCC2_CRIGR ENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRE Q8K223_MOUSE Q8K223_MOUSE ENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRE Q3UKK7_MOUSE Q3UKK7_MOUSE ENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRE ERCC2_MOUSE ERCC2_MOUSE ENGRGAVLLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRE Q8C487_MOUSE Q8C487_MOUSE ENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRE A1L590_BOVIN A1L590_BOVIN ENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRE ERCC2_BOVIN ERCC2_BOVIN ENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRE A5A791_PIG A5A791_PIG ENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRE Q2TB79_HUMAN Q2TB79_HUMAN ENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRE A8MX75_HUMAN A8MX75_HUMAN ENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRE ERCC2_HUMAN ERCC2_HUMAN ENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRE Q2TB78_HUMAN Q2TB78_HUMAN ENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRE Q7ZWH2_DANRE Q7ZWH2_DANRE ENGRGAILLSVARGKVSEGIDFVHHHVRSAL----------------------------- B5X1K2_SALSA B5X1K2_SALSA ENGRGAILLSVARGKVSEGIDFVHHFGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRE Q91941_XIPMA Q91941_XIPMA ENGRGAILLSVARGKVSEGIDFVHHFGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRE MATCH ******:******************. *:.: CONSENSUS ENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRE

Q66II2_XENTR Q66II2_XENTR NDFLTFDAMRHAAQCVGRAIRGKTDYGIMLFADKRYARSDKRGKLPLWIQEHLTDANLNL ERCC2_CRIGR ERCC2_CRIGR NDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARADKRGKLPRWIQEHLTDSNLNL Q8K223_MOUSE Q8K223_MOUSE NDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARADKRGKLPRWIQEHLTDSNLNL Q3UKK7_MOUSE Q3UKK7_MOUSE NDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARADKRGKLPRWIQEHLTDSNLNL ERCC2_MOUSE ERCC2_MOUSE NDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARADKRGKLPRWIQEHLTDSNLNL Q8C487_MOUSE Q8C487_MOUSE NDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARADKRGKLPRWIQEHLTDSNLNL A1L590_BOVIN A1L590_BOVIN NDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARADKRGKLPRWIQEHLTDANLNL ERCC2_BOVIN ERCC2_BOVIN NDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARADKRGKLPRWIQEHLTDANLNL A5A791_PIG A5A791_PIG NDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARADKRGKLPRWIQEHLTDANLNL Q2TB79_HUMAN Q2TB79_HUMAN NDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNL A8MX75_HUMAN A8MX75_HUMAN NDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNL ERCC2_HUMAN ERCC2_HUMAN NDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNL Q2TB78_HUMAN Q2TB78_HUMAN NDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNL Q7ZWH2_DANRE Q7ZWH2_DANRE --------------CL-------------------HSEPNPQGT---------------- B5X1K2_SALSA B5X1K2_SALSA NDFLTFDAMRHAAQCVGRAIRGKTDYGLMIFADKRYARADKRGKLPRWIQEHLTDGSLNL Q91941_XIPMA Q91941_XIPMA NDFLTFDAMRHAAQCLGRAIRGKTDYGLMIFADKRYARSDKRGKLPRWIQEHINDGSLNL MATCH *: .:. : :*. CONSENSUS NDFLTFDAMRHAAQCVGRAIRGKTDYGLM?FADKR?AR?DKRGKLPRWIQEHLTD?NLNL

Q66II2_XENTR Q66II2_XENTR TLDESVHLARHFLRQMAQPFRREDQLGLSLLTLEQLQSEEMLQKIQEIAHQV ERCC2_CRIGR ERCC2_CRIGR TVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLQSEETLRRVEQIAQQL Q8K223_MOUSE Q8K223_MOUSE TVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLQSEETLQRIEQIAQQL Q3UKK7_MOUSE Q3UKK7_MOUSE TVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLQSEETLQRIEQIAQQL ERCC2_MOUSE ERCC2_MOUSE TVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLQSEETLQRIEQIAQQL Q8C487_MOUSE Q8C487_MOUSE TVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLQSEETLQRIEQIAQQL A1L590_BOVIN A1L590_BOVIN TVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLESEETLRRIEQIAQQL ERCC2_BOVIN ERCC2_BOVIN TVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLESEETLRRIEQIAQQL A5A791_PIG A5A791_PIG TVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLESEETLRRIEQIAQQL Q2TB79_HUMAN Q2TB79_HUMAN TVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLESEETLQRIEQIAQQL A8MX75_HUMAN A8MX75_HUMAN TVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLESEETLKRIEQIAQQL ERCC2_HUMAN ERCC2_HUMAN TVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLESEETLKRIEQIAQQL Q2TB78_HUMAN Q2TB78_HUMAN TVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLESEETLQRIEQIAQQL Q7ZWH2_DANRE Q7ZWH2_DANRE ---TGV------------PQRPVSNPGE------------------------ B5X1K2_SALSA B5X1K2_SALSA TIDETVQLSKHFLRQMAQPFRQEDQLGLSLLTLEQLQSEDMLQKIAQIAHQA Q91941_XIPMA Q91941_XIPMA TVDEAVQLSKHFLRQMAQPFRQEDQLGLSLLTLEQLQSEEMLQKISQMAHQA MATCH * * : .: * CONSENSUS TVDEGVQ?AK?FLRQMAQPF?REDQLGLSLL?LEQL?SEE?L??I?QIA?Q?


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