Alignment of the gene Family HBG051888 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
A8WIP5_DANRE A8WIP5_DANRE -----MASSGTSVLQPRWKRVLGWSGPVPRPRHGHRAVAIKELMVVFGGGNEGIVDELHV A5D6R2_DANRE A5D6R2_DANRE TSPGVPGTTGA-PLQPRWKRVLGWSGPVPRPRHGHRAVAIKELMVVFGGGNEGIVDELHV Q7SZY1_DANRE Q7SZY1_DANRE TSPGVPGTTGA-PLQPRWKRVLGWSGPVPRPRHGHRAVAIKELMVVFGGGNEGIVDELHV Q640G9_XENLA Q640G9_XENLA -MAATPALSTAGALQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHV HCFC1_MESAU HCFC1_MESAU ASAVSPANLPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHV HCFC1_MOUSE HCFC1_MOUSE ASAVSPANLPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHV B1AUX1_MOUSE B1AUX1_MOUSE ASAVSPANLPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHV B1AUX2_MOUSE B1AUX2_MOUSE ASAVSPANLPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHV B2KII8_RHIFE B2KII8_RHIFE ASAVSPANSPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHV B7NZP5_RABIT B7NZP5_RABIT ASAVSPANSPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHV B5FW89_OTOGA B5FW89_OTOGA -----------------MAMCLGRSST--------------------------------- B0KWV2_CALJA B0KWV2_CALJA ------------------------------------------------------------ B1MTW3_CALMO B1MTW3_CALMO ASAVSPANSPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHV A9CB52_PAPAN A9CB52_PAPAN ASAVSPANSPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHV A6NEM2_HUMAN A6NEM2_HUMAN ASAVSPANLPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHV HCFC1_HUMAN HCFC1_HUMAN ASAVSPANLPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHV MATCH CONSENSUS ????????????????????????????????????????????????????????????

A8WIP5_DANRE A8WIP5_DANRE YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK A5D6R2_DANRE A5D6R2_DANRE YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK Q7SZY1_DANRE Q7SZY1_DANRE YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK Q640G9_XENLA Q640G9_XENLA YNTSTNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK HCFC1_MESAU HCFC1_MESAU YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK HCFC1_MOUSE HCFC1_MOUSE YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK B1AUX1_MOUSE B1AUX1_MOUSE YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK B1AUX2_MOUSE B1AUX2_MOUSE YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK B2KII8_RHIFE B2KII8_RHIFE YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK B7NZP5_RABIT B7NZP5_RABIT YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK B5FW89_OTOGA B5FW89_OTOGA -RVATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK B0KWV2_CALJA B0KWV2_CALJA ------------------------------------------------------------ B1MTW3_CALMO B1MTW3_CALMO YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK A9CB52_PAPAN A9CB52_PAPAN YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK A6NEM2_HUMAN A6NEM2_HUMAN YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK HCFC1_HUMAN HCFC1_HUMAN YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK MATCH CONSENSUS ????????????????????????????????????????????????????????????

A8WIP5_DANRE A8WIP5_DANRE RLKPKAPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYTLELRPG A5D6R2_DANRE A5D6R2_DANRE KLKPKAPKNGVPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYTLELRPG Q7SZY1_DANRE Q7SZY1_DANRE KLKPKAPKNGVPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYTLELRPG Q640G9_XENLA Q640G9_XENLA RLKAKAPKNGPPPCPRLGHSFSLVGSKCYLFGGLANDSEDPKNNIPRYLNDLYILELRAG HCFC1_MESAU HCFC1_MESAU RLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPG HCFC1_MOUSE HCFC1_MOUSE RLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPG B1AUX1_MOUSE B1AUX1_MOUSE RLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPG B1AUX2_MOUSE B1AUX2_MOUSE RLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPG B2KII8_RHIFE B2KII8_RHIFE RLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPG B7NZP5_RABIT B7NZP5_RABIT RLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPG B5FW89_OTOGA B5FW89_OTOGA RLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPG B0KWV2_CALJA B0KWV2_CALJA ------------------------------------------------------------ B1MTW3_CALMO B1MTW3_CALMO RLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPG A9CB52_PAPAN A9CB52_PAPAN RLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPG A6NEM2_HUMAN A6NEM2_HUMAN RLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPG HCFC1_HUMAN HCFC1_HUMAN RLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPG MATCH CONSENSUS ????????????????????????????????????????????????????????????

A8WIP5_DANRE A8WIP5_DANRE SNVAGWDIPITYGVLPPPRESHTAVVYTEKTSKKSRLIIYGGMSGCRLGDLWTLDIDTLT A5D6R2_DANRE A5D6R2_DANRE SSVAGWDVPVTYGVLPPPRESHTAVIYTEKVTKKSRLVIYGGMSGCRLGDLWTLDIDTLT Q7SZY1_DANRE Q7SZY1_DANRE SSVAGWDVPVTYGVLPPPRESHTAVIYTEKVTKKSRLVIYGGMSGCRLGDLWTLDIDTLT Q640G9_XENLA Q640G9_XENLA SGVVAWDVPITYGILPPPRESHTAVVYTDKDNKKSRLVIYGGMSGCRLGDLWILDIDTLT HCFC1_MESAU HCFC1_MESAU SGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIETLT HCFC1_MOUSE HCFC1_MOUSE SGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIETLT B1AUX1_MOUSE B1AUX1_MOUSE SGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIETLT B1AUX2_MOUSE B1AUX2_MOUSE SGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIETLT B2KII8_RHIFE B2KII8_RHIFE SGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIETLT B7NZP5_RABIT B7NZP5_RABIT SGVVAWDIPITYGVLPPPRESHTAVVYTERDNKKSKLVIYGGMSGCRLGDLWTLDIETLT B5FW89_OTOGA B5FW89_OTOGA SGVVAWDIPITYGVLPPPRESHTAVVYTERDNKKSKLVIYGGMSGCRLGDLWTLDIETLT B0KWV2_CALJA B0KWV2_CALJA ------------------------------------------------------------ B1MTW3_CALMO B1MTW3_CALMO SGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIDTLT A9CB52_PAPAN A9CB52_PAPAN SGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIDTLT A6NEM2_HUMAN A6NEM2_HUMAN SGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIDTLT HCFC1_HUMAN HCFC1_HUMAN SGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIDTLT MATCH CONSENSUS ????????????????????????????????????????????????????????????

A8WIP5_DANRE A8WIP5_DANRE WNKPAISGAAPLPRSLHSATTITNKMFVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL A5D6R2_DANRE A5D6R2_DANRE WNKPAISGAAPLPRSLHSATTITNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL Q7SZY1_DANRE Q7SZY1_DANRE WNKPAISGAAPLPRSLHSATTITNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL Q640G9_XENLA Q640G9_XENLA WSKPSLNGVAPLPRSLHSATTILNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL HCFC1_MESAU HCFC1_MESAU WNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL HCFC1_MOUSE HCFC1_MOUSE WNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL B1AUX1_MOUSE B1AUX1_MOUSE WNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL B1AUX2_MOUSE B1AUX2_MOUSE WNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL B2KII8_RHIFE B2KII8_RHIFE WNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL B7NZP5_RABIT B7NZP5_RABIT WNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL B5FW89_OTOGA B5FW89_OTOGA WNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL B0KWV2_CALJA B0KWV2_CALJA -------------------------MYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL B1MTW3_CALMO B1MTW3_CALMO WNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL A9CB52_PAPAN A9CB52_PAPAN WNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL A6NEM2_HUMAN A6NEM2_HUMAN WNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL HCFC1_HUMAN HCFC1_HUMAN WNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL MATCH *:********************************* CONSENSUS ?????????????????????????M?VFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL

A8WIP5_DANRE A8WIP5_DANRE DSMSWETILMDTLEDNIPRARAGHCSVAINNRLYVWSGRDGYRKAWNNQVCCKDLWYLET A5D6R2_DANRE A5D6R2_DANRE DTLAWETVLMDTLEDNIPRARAGHCAVAINNRLYIWSGRDGYRKAWNNQVCCKDLWYLET Q7SZY1_DANRE Q7SZY1_DANRE DTLAWETVLMDTLEDNIPRARAGHCAVAINNRLYIWSGRDGYRKAWNNQVCCKDLWYLET Q640G9_XENLA Q640G9_XENLA ESMSWEHIVIDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLET HCFC1_MESAU HCFC1_MESAU DTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLET HCFC1_MOUSE HCFC1_MOUSE DTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLET B1AUX1_MOUSE B1AUX1_MOUSE DTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLET B1AUX2_MOUSE B1AUX2_MOUSE DTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLET B2KII8_RHIFE B2KII8_RHIFE DTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLET B7NZP5_RABIT B7NZP5_RABIT -------------------------------------GMASSGSEWP-----------AG B5FW89_OTOGA B5FW89_OTOGA DTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLET B0KWV2_CALJA B0KWV2_CALJA DTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLET B1MTW3_CALMO B1MTW3_CALMO DTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLET A9CB52_PAPAN A9CB52_PAPAN DTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLET A6NEM2_HUMAN A6NEM2_HUMAN DTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLET HCFC1_HUMAN HCFC1_HUMAN DTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLET MATCH * . . * CONSENSUS ?????????????????????????????????????G???????W??????????????

A8WIP5_DANRE A8WIP5_DANRE DRPQPPSRVQLVRANTNSLEVSWGAVPTADTYLLQLQKYDIPA-ATAATSPTVNPMPSVP A5D6R2_DANRE A5D6R2_DANRE ERPNPPSRVQLVRANTNSLEVSWGAVSTADTYLLQLQKYDIPA-ATAATSPALNAAPSLP Q7SZY1_DANRE Q7SZY1_DANRE ERPNPPSRVQLVRANTNSLEVSWGAVSTADTYLLQLQKYDIPA-ATAATSPALNAAPSLP Q640G9_XENLA Q640G9_XENLA EKPPAPARVQLVRANTNSLEVSWGAVPTADSYLLQLQKYDIPA-AAAAMSPA-NPVPSVP HCFC1_MESAU HCFC1_MESAU EKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVP HCFC1_MOUSE HCFC1_MOUSE EKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVP B1AUX1_MOUSE B1AUX1_MOUSE EKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVP B1AUX2_MOUSE B1AUX2_MOUSE EKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVP B2KII8_RHIFE B2KII8_RHIFE EKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVP B7NZP5_RABIT B7NZP5_RABIT EKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVP B5FW89_OTOGA B5FW89_OTOGA EKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVP B0KWV2_CALJA B0KWV2_CALJA EKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVP B1MTW3_CALMO B1MTW3_CALMO EKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVP A9CB52_PAPAN A9CB52_PAPAN EKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVP A6NEM2_HUMAN A6NEM2_HUMAN EKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVP HCFC1_HUMAN HCFC1_HUMAN EKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVP MATCH ::* .*:*******************.***:************ *::* **: *. **:* CONSENSUS ??P??P?RVQLVRANTNSLEVSWGAV?TAD?YLLQLQKYDIPA?A??A?SP??N??PS?P

A8WIP5_DANRE A8WIP5_DANRE VNSPKSPVPAAAAPAAQSMPLSGVTLVPQVPS--PTTAM-------PTSPLAAS-PRG-- A5D6R2_DANRE A5D6R2_DANRE GNSPKSPAPAAAAPSAQSLPHSGITSVPQAAS--PTAS---VLPGTPASPLAASMARG-- Q7SZY1_DANRE Q7SZY1_DANRE GNSPKSPAPAAAAPSAQSLPHSGITSVPQAAS--PTAS---VLPGTPASPLAASMARG-- Q640G9_XENLA Q640G9_XENLA VNPPKSPAPASAAPTVQQVAHTGITLLPQAASLPPTTATIQVLPTMPGSPIAVSAALRTQ HCFC1_MESAU HCFC1_MESAU ANPPKSPAPAAAAPAVQPLTQVGITLVPQAAAAPPSTTTIQVLPTVPGSSISVPTAARAQ HCFC1_MOUSE HCFC1_MOUSE ANPPKSPAPAAAAPAVQPLTQVGITLVPQAATAPPSTTTIQVLPTVPGSSISVPTAARTQ B1AUX1_MOUSE B1AUX1_MOUSE ANPPKSPAPAAAAPAVQPLTQVGITLVPQAATAPPSTTTIQVLPTVPGSSISVPTAARTQ B1AUX2_MOUSE B1AUX2_MOUSE ANPPKSPAPAAAAPAVQPLTQVGITLVPQAATAPPSTTTIQVLPTVPGSSISVPTAARTQ B2KII8_RHIFE B2KII8_RHIFE TNPPKSPAPAAAAPAVQPLTQVGITLLPQAAAAPPTTTTIQVLPPVPGSSISVPAAARTQ B7NZP5_RABIT B7NZP5_RABIT ANPPKSPAPAAAAPAVQPLTQVGITLLPQAAAAPPTTTTIQVLPTVPGSSISVPTAARTQ B5FW89_OTOGA B5FW89_OTOGA ANPPKSPAPAAAAPAVQPLTQVGITLLPQAAAAPPTTTTIQVLPTVPGSSISVPTAARTQ B0KWV2_CALJA B0KWV2_CALJA ANPPKSPAPAAAAPAVQPLTQVGITLLPQAAPAPPTTTTIQVLPTVPGSSISVPTAARTQ B1MTW3_CALMO B1MTW3_CALMO ANPPKSPAPAAAAPAVQPLTQVGITLLPQAAPAPPTTTTIQVLPTVPGSSISVPTAARTQ A9CB52_PAPAN A9CB52_PAPAN ANPPKSPAPAAAAPAVQPLTQVGITLLPQAAPAPPTTTTIQVLPTVPGSSISVPTAARTQ A6NEM2_HUMAN A6NEM2_HUMAN ANPPKSPAPAAAAPAVQPLTQVGITLLPQAAPAPPTTTTIQVLPTVPGSSISVPTAARTQ HCFC1_HUMAN HCFC1_HUMAN ANPPKSPAPAAAAPAVQPLTQVGITLLPQAAPAPPTTTTIQVLPTVPGSSISVPTAARTQ MATCH *.****.**:***:.* :. *:* :**... *::: * *.::.. . CONSENSUS ?N?PKSP?PA?AAP??Q?????G?T??PQ?????P???????????P?S???????????

A8WIP5_DANRE A8WIP5_DANRE --PAILKVAAPHSTPGTSVVTVRQATPGAKSPVTVTSLPAGVRMVVPAQSTQGTPIGSSP A5D6R2_DANRE A5D6R2_DANRE --PAILKVAAPQSGTGASIVTVRQASQVGKSPVTVASLPAGVRMVVPSQTAQGTPIGSSP Q7SZY1_DANRE Q7SZY1_DANRE --PAILKVAAPQSGTGASIVTVRQASQVGKSPVTVASLPAGVRMVVPSQTAQGT-IGSSP Q640G9_XENLA Q640G9_XENLA AVPAVLKVGGQQSTLSTPLVTVRPANQISKAPVTVTSLPPGVRMVVPAQSTQGAPIGSSQ HCFC1_MESAU HCFC1_MESAU GVPAVLKVTGPQATTGTPLVTMRPAGQAGKAPVTVTSLPASVRMVVPTQSAQGTVIGSNP HCFC1_MOUSE HCFC1_MOUSE GRPAVLKVTGPQATTGTPLVTMRPASQAGKAPVTVTSLPASVRMVVPTQSAQGTVIGSNP B1AUX1_MOUSE B1AUX1_MOUSE GVPAVLKVTGPQATTGTPLVTMRPASQAGKAPVTVTSLPASVRMVVPTQSAQGTVIGSNP B1AUX2_MOUSE B1AUX2_MOUSE GVPAVLKVTGPQATTGTPLVTMRPASQAGKAPVTVTSLPASVRMVVPTQSAQGTVIGSNP B2KII8_RHIFE B2KII8_RHIFE GVPAVLKVTGPQATTGTPLVTMRPASQAGKAPVTMTSLPAGVRMVVPTQSAQGTVIGSNP B7NZP5_RABIT B7NZP5_RABIT GVPAVLKVTGPQATTGTPLVTMRPASQPGKAPVTVTSLPAGVRMVVPTQSAQGTVIGSNP B5FW89_OTOGA B5FW89_OTOGA GVPAVLKVTGPQATTGTPLVTMRPASQAGKAPVTVTSLPAGVRMVVPTQSAQGTVIGSSP B0KWV2_CALJA B0KWV2_CALJA GVPAVLKVTGPQATTGTPLVTMRPASQAGKAPVTVTSLPAGVRMVVPTQSAQGTVIGSSP B1MTW3_CALMO B1MTW3_CALMO GVPAVLKVTGPQATTGTPLVTMRPASQAGKAPVTVTSLPAGVRMVVPTQSAQGTVIGSSP A9CB52_PAPAN A9CB52_PAPAN GVPAVLKVTGPQATTGTPLVTMRPTSQAGKAPVTVTSLPAGVRMVVPTQSAQGTVIGSSP A6NEM2_HUMAN A6NEM2_HUMAN GVPAVLKVTGPQATTGTPLVTMRPASQAGKAPVTVTSLPAGVRMVVPTQSAQGTVIGSSP HCFC1_HUMAN HCFC1_HUMAN GVPAVLKVTGPQATTGTPLVTMRPASQAGKAPVTVTSLPAGVRMVVPTQSAQGTVIGSSP MATCH **:*** . :: .:.:**:* : .*:***::***..******:*::**: ***. CONSENSUS ??PA?LKV???????????VT?R??????K?PVT??SLP??VRMVVP?Q??QG??IGS??

A8WIP5_DANRE A8WIP5_DANRE QMSGMAALAAAAAATQKIPPSSATTVLNVPAGATLVKTVAVTPGSTTLPATVKVA-SPVM A5D6R2_DANRE A5D6R2_DANRE QMSGMAALAAAAAATQKIPPSPGATVLNMPAGATIVKTVAVTPGASTLPTTVKVA-SPLM Q7SZY1_DANRE Q7SZY1_DANRE QMSGMAALAAAAAATQKIPPSPGATVLNMPAGATIVKTVAVTPGASTLPTTVKVA-SPLM Q640G9_XENLA Q640G9_XENLA PMSGMAALAAAAAATQKIPPSSAPTMLGVPAGATMVKSVAVPSGVTSLPTTVKVASSPIM HCFC1_MESAU HCFC1_MESAU QMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTVAVTPGTTTLPATVKVASSPVM HCFC1_MOUSE HCFC1_MOUSE QMSGMAALAAAAAATQKIPPSSAPTAWSVPAGTTIVKTVAVTPGTTTLPATVKVASSPVM B1AUX1_MOUSE B1AUX1_MOUSE QMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTVAVTPGTTTLPATVKVASSPVM B1AUX2_MOUSE B1AUX2_MOUSE QMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTVAVTPGTTTLPATVKVASSPVM B2KII8_RHIFE B2KII8_RHIFE QMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTVAVTPGTTTLPATVKVASSPVM B7NZP5_RABIT B7NZP5_RABIT QMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTVAVTPGTTTLPATVKVASSPVM B5FW89_OTOGA B5FW89_OTOGA QMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTVAVTPGTTTLPATVKVASSPVM B0KWV2_CALJA B0KWV2_CALJA QMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTMAVTPGTTTLPATVKVASSPVM B1MTW3_CALMO B1MTW3_CALMO QMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTMAVTPGTTTLPATVKVASSPVM A9CB52_PAPAN A9CB52_PAPAN QMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTMAVTPGTTTLPATVKVASSPVM A6NEM2_HUMAN A6NEM2_HUMAN QMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTMAVTPGTTTLPATVKVASSPVM HCFC1_HUMAN HCFC1_HUMAN QMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTMAVTPGTTTLPATVKVASSPVM MATCH ********************...* .:***:*:**::**..* ::**:***** **:* CONSENSUS ?MSGMAALAAAAAATQKIPPS???T????PAG?T?VK??AV??G???LP?TVKVA?SP?M

A8WIP5_DANRE A8WIP5_DANRE VTNPATRMLKTAAAQVGTSAISTPNTPTRPIITVHKSGTVTVAQQAQVVTTMVGGVTKTI A5D6R2_DANRE A5D6R2_DANRE VSNPATRMLKTAAAQVATPTVSSPTTGARPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI Q7SZY1_DANRE Q7SZY1_DANRE VSNPATRMLKTAAAQVATPTVSSPTTGARPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI Q640G9_XENLA Q640G9_XENLA VSNPATRMLKTAAAQVGTSVPGS-NTQNRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI HCFC1_MESAU HCFC1_MESAU VSNPATRMLKTAAAQVGTSVSSAANTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI HCFC1_MOUSE HCFC1_MOUSE VSNPATRMLKTAAAQVGTSVSSAANTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI B1AUX1_MOUSE B1AUX1_MOUSE VSNPATRMLKTAAAQVGTSVSSAANTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI B1AUX2_MOUSE B1AUX2_MOUSE VSNPATRMLKTAAAQVGTSVSSAANTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI B2KII8_RHIFE B2KII8_RHIFE VSNPATRMLKTAAAQVGTSVSSAANTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI B7NZP5_RABIT B7NZP5_RABIT VSNPATRMLKTAAAQVGTSVSSAANTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI B5FW89_OTOGA B5FW89_OTOGA VSNPATRMLKTAAAQVGTSVSSATNTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI B0KWV2_CALJA B0KWV2_CALJA VSNPATRMLKTAAAQVGTSVSSATNTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI B1MTW3_CALMO B1MTW3_CALMO VSNPATRMLKTAAAQVGTSVSSATNTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI A9CB52_PAPAN A9CB52_PAPAN VSNPATRMLKTAAAQVGTSVSSATNTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI A6NEM2_HUMAN A6NEM2_HUMAN VSNPATRMLKTAAAQVGTSVSSATNTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI HCFC1_HUMAN HCFC1_HUMAN VSNPATRMLKTAAAQVGTSVSSATNTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI MATCH *:**************.*.. .: .* ***********************:******** CONSENSUS V?NPATRMLKTAAAQV?T???????T??RPIITVHKSGTVTVAQQAQVVTT?VGGVTKTI

A8WIP5_DANRE A8WIP5_DANRE TLVKSPITMGGSGALYSQLSSLGKVMSVVQTKPVQTSAVTGQAGS-SPVTLIQTKTPLPA A5D6R2_DANRE A5D6R2_DANRE TLVKSPLSMGGN--L---ISNLGKVVSVVQNKPVQSATVTGQASN-PLTQIIQTKGPLPP Q7SZY1_DANRE Q7SZY1_DANRE TLVKSPLSMGGN--L---ISNLGKVVSVVQNKPVQSATVTGQASN-PLTQIIQTKGPLPP Q640G9_XENLA Q640G9_XENLA TLVKSPISVPGGSAL---ISNLGKMMSVVQTKPVQTSAITGQASTGPLTQIIQTKGPLPA HCFC1_MESAU HCFC1_MESAU TLVKSPISVPGGSAL---ISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPA HCFC1_MOUSE HCFC1_MOUSE TLVKSPISVPGGSAL---ISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPA B1AUX1_MOUSE B1AUX1_MOUSE TLVKSPISVPGGSAL---ISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPA B1AUX2_MOUSE B1AUX2_MOUSE TLVKSPISVPGGSAL---ISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPA B2KII8_RHIFE B2KII8_RHIFE TLVKSPISVPGGSAL---ISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPA B7NZP5_RABIT B7NZP5_RABIT TLVKSPISVPGGSAL---ISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPA B5FW89_OTOGA B5FW89_OTOGA TLVKSPISVPGGSAL---ISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPA B0KWV2_CALJA B0KWV2_CALJA TLVKSPISVPGGSAL---ISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPA B1MTW3_CALMO B1MTW3_CALMO TLVKSPISVPGGSAL---ISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPA A9CB52_PAPAN A9CB52_PAPAN TLVKSPISVPGGSAL---ISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPA A6NEM2_HUMAN A6NEM2_HUMAN TLVKSPISVPGGSAL---ISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPA HCFC1_HUMAN HCFC1_HUMAN TLVKSPISVPGGSAL---ISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPA MATCH ******::: *. * :*.***::****.****::::****.. . . :**** ***. CONSENSUS TLVKSP????G???L????S?LGK??SVVQ?KPVQ????TGQA????????IQTK?PLP?

A8WIP5_DANRE A8WIP5_DANRE GTILKLVTSADGKPTTIITTSQAGGTGTKPTILGISSVSPTTTNKPG-TTIIKTIPMSAL A5D6R2_DANRE A5D6R2_DANRE GTILKLVTSADGKPTTIITTSQAGGTGNKPTILGISGMSPTSTSKPGTTTIIKTIPMSAV Q7SZY1_DANRE Q7SZY1_DANRE GTILKLVTSADGKPTTIITTSQAGGTGNKPTILGISGMSPTSTSKPGTTTIIKTIPMSAV Q640G9_XENLA Q640G9_XENLA GTILKLVTSADGKPATIITTTQAGGTGTKPTILGISSVSP-NTTKPGTTTIIKTIPMSAI HCFC1_MESAU HCFC1_MESAU GTILKLVTSADGKPTTIITTTQASGAGSKPTILGISSVSP-STTKPGTTTIIKTIPMSAI HCFC1_MOUSE HCFC1_MOUSE GTILKLVTSADGKPTTIITTTQASGAGTKPTILGISSVSP-STTKPGTTTIIKTIPMSAI B1AUX1_MOUSE B1AUX1_MOUSE GTILKLVTSADGKPTTIITTTQASGAGTKPTILGISSVSP-STTKPGTTTIIKTIPMSAI B1AUX2_MOUSE B1AUX2_MOUSE GTILKLVTSADGKPTTIITTTQASGAGTKPTILGISSVSP-STTKPGTTTIIKTIPMSAI B2KII8_RHIFE B2KII8_RHIFE GTILKLVTSADGKPTTIITTTQASGAGTKPTILGISSVSP-STTKPGTTTIIKTIPMSAI B7NZP5_RABIT B7NZP5_RABIT GTILKLVTSADGKPTTIITTTQASGAGTKPTILGISSVSP-STTKPGTTTIIKTIPMSAI B5FW89_OTOGA B5FW89_OTOGA GTILKLVTSADGKPTTIITTTQASGAGAKPTILGISSVSP-STTKPGTTTIIKTIPMSAI B0KWV2_CALJA B0KWV2_CALJA GTILKLVTSADGKPTTIITTTQASGAGTKPTILGISSVSP-STTKPGTTTIIKTIPMSAI B1MTW3_CALMO B1MTW3_CALMO GTILKLVTSADGKPTTIITTTQASGAGTKPTILGISSVSP-STTKPGTTTIIKTIPMSAI A9CB52_PAPAN A9CB52_PAPAN GTILKLVTSADGKPTTIITTTQASGAGTKPTILGISSVSP-STTKPGTTTIIKTIPMSAI A6NEM2_HUMAN A6NEM2_HUMAN GTILKLVTSADGKPTTIITTTQASGAGTKPTILGISSVSP-STTKPGTTTIIKTIPMSAI HCFC1_HUMAN HCFC1_HUMAN GTILKLVTSADGKPTTIITTTQASGAGTKPTILGISSVSP-STTKPGTTTIIKTIPMSAI MATCH **************:*****:**.*:* ********.:** .*.*** ***********: CONSENSUS GTILKLVTSADGKP?TIITT?QA?G?G?KPTILGIS??SP??T?KPG?TTIIKTIPMSA?

A8WIP5_DANRE A8WIP5_DANRE ---QGATGVTSSAGIKSPITIITTKVVTPGTGTPGKIITAVPKL-TGAGQQGVTQVVLKG A5D6R2_DANRE A5D6R2_DANRE --QQGAAGVTSTTGVKSPITIITTKVMTS--GTPGKIITAMPKIGTAAGQQGLTQVVLKG Q7SZY1_DANRE Q7SZY1_DANRE --QQGAAGVTSTTGVKSPITIITTKVMTS--GTPGKIITAMPKIGTAAGQQGLTQVVLKG Q640G9_XENLA Q640G9_XENLA ITQAGATGVTSTAGIKSPITILTTKMGTSGTGTPAKIITAVPKHTATLGQQGLTQVVLKG HCFC1_MESAU HCFC1_MESAU ITQAGATGVTSTPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKG HCFC1_MOUSE HCFC1_MOUSE ITQAGATGVTSSPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKG B1AUX1_MOUSE B1AUX1_MOUSE ITQAGATGVTSSPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKG B1AUX2_MOUSE B1AUX2_MOUSE ITQAGATGVTSSPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKG B2KII8_RHIFE B2KII8_RHIFE ITQAGATGVTSTPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKG B7NZP5_RABIT B7NZP5_RABIT ITQAGATGVTSSPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKG B5FW89_OTOGA B5FW89_OTOGA ITQAGAAGVTSSPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKG B0KWV2_CALJA B0KWV2_CALJA ITQAGATGVTSSPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKG B1MTW3_CALMO B1MTW3_CALMO ITQAGATGVTSSPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKG A9CB52_PAPAN A9CB52_PAPAN ITQAGATGVTSSPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKG A6NEM2_HUMAN A6NEM2_HUMAN ITQAGATGVTSSPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKG HCFC1_HUMAN HCFC1_HUMAN ITQAGATGVTSSPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKG MATCH **:****:.*:******:***: *. *:*.*****:** : ****:******* CONSENSUS ????GA?GVTS??G?KSPITI?TTK??T???G?P?KIITA?PK?????GQQG?TQVVLKG

A8WIP5_DANRE A8WIP5_DANRE APGQPGTILRTVPMGGVRLVSPGTVSADKPTVTTLVVKGTTGVTTLGTVTGTVSTSVAGA A5D6R2_DANRE A5D6R2_DANRE APGQPGTILRTVPMGGVRLVSP--VSGVKPTVTTLVVKGTTGVTTLGTVTGTVSSSLAGG Q7SZY1_DANRE Q7SZY1_DANRE APGQPGTILRTVPMGGVRLVSP--VSGVKPTVTTLVVKGTTGVTTLGTVTGTVSSSLAGG Q640G9_XENLA Q640G9_XENLA APGQPGTILRTVPMSGMRLVTP--VSAVKPTVTTLVVKGTTGVTTLGTVSGTVSTSLAGG HCFC1_MESAU HCFC1_MESAU APGQPGAILRTVPMSGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGA HCFC1_MOUSE HCFC1_MOUSE APGQPGTILRTVPMGGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGA B1AUX1_MOUSE B1AUX1_MOUSE APGQPGTILRTVPMGGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGA B1AUX2_MOUSE B1AUX2_MOUSE APGQPGTILRTVPMGGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGA B2KII8_RHIFE B2KII8_RHIFE APGQPGTILRTVPMGGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGA B7NZP5_RABIT B7NZP5_RABIT APGQPGTILRTVPMGGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGA B5FW89_OTOGA B5FW89_OTOGA APGQPGTILRTVPMGGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGA B0KWV2_CALJA B0KWV2_CALJA APGQPGTILRTVPMGGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGA B1MTW3_CALMO B1MTW3_CALMO APGQPGTILRTVPMGGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGA A9CB52_PAPAN A9CB52_PAPAN APGQPGTILRTVPMGGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGA A6NEM2_HUMAN A6NEM2_HUMAN APGQPGTILRTVPMGGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGA HCFC1_HUMAN HCFC1_HUMAN APGQPGTILRTVPMGGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGA MATCH ******:*******.*:***:* **. **:******************:****:*:**. CONSENSUS APGQPG?ILRTVPM?G?RLV?P??VS??KP?VTTLVVKGTTGVTTLGTV?GTVS?S?AG?

A8WIP5_DANRE A8WIP5_DANRE NV--ANASLATPVTTLASIATLSSQVINPTAITVSAAQTNLATA--------TIQSASQP A5D6R2_DANRE A5D6R2_DANRE SLASANATLATPITTLGTIATLASQVINATNVT--AAQSNLT----------TVTSTMQP Q7SZY1_DANRE Q7SZY1_DANRE SLASANATLATPITTLGTIATLASQVINATNVT--AAQSNLT----------TVTSTMQP Q640G9_XENLA Q640G9_XENLA GVHN-SASLATPINTLGTIATLSSQVINPGAITMSAAQTSLTAASGLSTPTITMQPLSQP HCFC1_MESAU HCFC1_MESAU GAHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQP HCFC1_MOUSE HCFC1_MOUSE GAHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQP B1AUX1_MOUSE B1AUX1_MOUSE GAHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQP B1AUX2_MOUSE B1AUX2_MOUSE GAHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQP B2KII8_RHIFE B2KII8_RHIFE GGHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAASGLTTPTITMQPVSQP B7NZP5_RABIT B7NZP5_RABIT GGHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLSTPTITMQPVSQP B5FW89_OTOGA B5FW89_OTOGA GGHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLSTPTITMQPVSQP B0KWV2_CALJA B0KWV2_CALJA GGHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQP B1MTW3_CALMO B1MTW3_CALMO GGHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQP A9CB52_PAPAN A9CB52_PAPAN GGHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQP A6NEM2_HUMAN A6NEM2_HUMAN GGHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQP HCFC1_HUMAN HCFC1_HUMAN GGHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQP MATCH . .*:****:.**.:****:*****. :* ***:.*: *: . ** CONSENSUS ??????A?LATP??TL??IATL?SQVIN????T??AAQ??L???????????T?????QP

A8WIP5_DANRE A8WIP5_DANRE TQVTLITTPSGAEAQPGQDLPVSFLASPTSEQPSTT----GADAGD-SAGDGATTVTLVC A5D6R2_DANRE A5D6R2_DANRE TQVTLITTPSGVEAQPGQDLPVSFLASPTSEQPTST----ESGTGE-ASG----SVTLVC Q7SZY1_DANRE Q7SZY1_DANRE TQVTLITTPSGVEAQPGQDLPVSFLASPTSEQPTST----ESGTGE-ASG----SVTLVC Q640G9_XENLA Q640G9_XENLA TQVTLITTPSGVEAQPVHDLPVSILASPTSDQPTATVTIADSGQGD-QPG----TVTLVC HCFC1_MESAU HCFC1_MESAU TQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPG----TVTLVC HCFC1_MOUSE HCFC1_MOUSE TQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPG----TVTLVC B1AUX1_MOUSE B1AUX1_MOUSE TQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPG----TVTLVC B1AUX2_MOUSE B1AUX2_MOUSE TQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPG----TVTLVC B2KII8_RHIFE B2KII8_RHIFE TQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPG----TVTLVC B7NZP5_RABIT B7NZP5_RABIT TQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPG----TVTLVC B5FW89_OTOGA B5FW89_OTOGA TQVTLITAPSGVEAQPVHDLPVSILASPTTEQPSATVTIADSGQGDVQPG----TVTLVC B0KWV2_CALJA B0KWV2_CALJA TQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPG----TVTLVC B1MTW3_CALMO B1MTW3_CALMO TQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPG----TVTLVC A9CB52_PAPAN A9CB52_PAPAN TQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPG----TVTLVC A6NEM2_HUMAN A6NEM2_HUMAN TQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPG----TVTLVC HCFC1_HUMAN HCFC1_HUMAN TQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPG----TVTLVC MATCH *******:***.**** :*****:*****::**::* :. *: .* :***** CONSENSUS TQVTLIT?PSG?EAQP??DLPVS?LASPT??QP??T????????G????G?????VTLVC

A8WIP5_DANRE A8WIP5_DANRE SNPPCETHETGTTNTATTA-SAKIG---------------------------------TE A5D6R2_DANRE A5D6R2_DANRE SNPPCETHETGTTNTATTA-TSNMGAGPA---------------------------GTVQ Q7SZY1_DANRE Q7SZY1_DANRE SNPPCETHETGTTNTATTA-TSNMGAGPA---------------------------GTVQ Q640G9_XENLA Q640G9_XENLA SNPPCETHETGTTNTATTSLVNLSSIVQQPGGTLQFVCEGQE-PGTYVATSLAQANGSVV HCFC1_MESAU HCFC1_MESAU SNPPCETHETGTTNTATTTVVANLGGHPQP-TQVQFVCDRQEAAASLVTSAVGQQNGNVV HCFC1_MOUSE HCFC1_MOUSE SNPPCETHETGTTNTATTTVVANLGGHPQP-TQVQFVCDRQETAASLVTSAVGQQNGNVV B1AUX1_MOUSE B1AUX1_MOUSE SNPPCETHETGTTNTATTTVVANLGGHPQP-TQVQFVCDRQETAASLVTSAVGQQNGNVV B1AUX2_MOUSE B1AUX2_MOUSE SNPPCETHETGTTNTATTTVVANLGGHPQP-TQVQFVCDRQETAASLVTSAVGQQNGNVV B2KII8_RHIFE B2KII8_RHIFE SNPPCETHETGTTNTATTTVVANLGGHPQP-TQVQFVCDRQDAAASLVTSTVGQQNGSVV B7NZP5_RABIT B7NZP5_RABIT SNPPCETHETGTTNTATTTVVANLGGHPQP-TQVQFVCDRQEAAATLVTSAVAQQNGSVV B5FW89_OTOGA B5FW89_OTOGA SNPPCETHETGTTNTATTTVVANLGGHPQP-TQVQFVCDRQEAAASLVTSTMGQQNGSVV B0KWV2_CALJA B0KWV2_CALJA SNPPCETHETGTTNTATTTVVANLGGHPQP-TQVQFVCDRQDAAASLVTSTVGQQNGSVV B1MTW3_CALMO B1MTW3_CALMO SNPPCETHETGTTNTATTTVVANLGGHPQP-TQVQFVCDRQEATASLVTSTVGQQNGSVV A9CB52_PAPAN A9CB52_PAPAN SNPPCETHETGTTNTATTTVVANLGGHPQP-TQVQFVCDRQEAAASLVTSTVGQQNGSVV A6NEM2_HUMAN A6NEM2_HUMAN SNPPCETHETGTTNTATTTVVANLGGHPQP-TQVQFVCDRQEAAASLVTSTVGQQNGSVV HCFC1_HUMAN HCFC1_HUMAN SNPPCETHETGTTNTATTTVVANLGGHPQP-TQVQFVCDRQEAAASLVTSTVGQQNGSVV MATCH ******************: . . CONSENSUS SNPPCETHETGTTNTATT??????????????????????????????????????????

A8WIP5_DANRE A8WIP5_DANRE QICSNPPCETHVTGTTNTSTTASANMGRAQQ----VCTNPPSETHDTGTTNTATTASCNM A5D6R2_DANRE A5D6R2_DANRE RVCSN----------------------------------PPCETHETGTTNTATTASANM Q7SZY1_DANRE Q7SZY1_DANRE RVCSN----------------------------------PPCETHETGTTNTATTASANM Q640G9_XENLA Q640G9_XENLA RVCSNPPCETHETGTTQTSTTAMASI-GQTGIVTRVCSNPPCETHETGTTQTPTTAMSNI HCFC1_MESAU HCFC1_MESAU RVCSNPPCETHETGTTNTATTATSNMAGQHG-----CSNPPCETHETGTTSTATTAMSSM HCFC1_MOUSE HCFC1_MOUSE RVCSNPPCETHETGTTNTATTATSNMAGQHG-----SSNPPCETHETGTTSTATTAMSSM B1AUX1_MOUSE B1AUX1_MOUSE RVCSNPPCETHETGTTNTATTATSNMAGQHG-----CSNPPCETHETGTTSTATTAMSSM B1AUX2_MOUSE B1AUX2_MOUSE RVCSNPPCETHETGTTNTATTATSNMAGQHG-----CSNPPCETHETGTTSTATTAMSSM B2KII8_RHIFE B2KII8_RHIFE RVCSNPPCETHETGTTNTATTATSNMAGQHG-----CSNPPCETHETGTTNTASTAMSSI B7NZP5_RABIT B7NZP5_RABIT RVCSNPPCETHETGTTNTATTATSNMAGQHG-----CSNPPCETHETGTTSTATTAVSSI B5FW89_OTOGA B5FW89_OTOGA RVCSNPPCETHETGTTNTATTATSNMAGQHS-----CSDPPCETHETGTTNTATTAMSNV B0KWV2_CALJA B0KWV2_CALJA RVCSNPPCETHETGTTNTATTATSNMAGQHG-----CSNPPCETHETGTTNTATTAMSSV B1MTW3_CALMO B1MTW3_CALMO RVCSNPPCETHETGTTNTATTATSNMAGQHG-----CSNPPCETHETGTTNTATTAMSSV A9CB52_PAPAN A9CB52_PAPAN RVCSNPPCETHETGTTTTATTATSNMAGQHG-----CSNPPCETHETGTTNTATTAMSSV A6NEM2_HUMAN A6NEM2_HUMAN RVCSNPPCETHETGTTNTATTATSNMAGQHG-----CSNPPCETHETGTTNTATTAMSSV HCFC1_HUMAN HCFC1_HUMAN RVCSNPPCETHETGTTNTATTATSNMAGQHG-----CSNPPCETHETGTTNTATTAMSSV MATCH ::*** **.***:****.*.:** ..: CONSENSUS ??CSN??????????????????????????????????PP?ETH?TGTT?T??TA????

A8WIP5_DANRE A8WIP5_DANRE GSTEMGTVNSKPGSSSPPASSSSEPSTPVSESGAEAGVMRPENLRTGTTYTSTTARSNMG A5D6R2_DANRE A5D6R2_DANRE GA-----VQRVCS------------------------NPPCETHETGTTSTTTTASSN-- Q7SZY1_DANRE Q7SZY1_DANRE GA-----VQRVCS------------------------NPPCETHETGTTSTTTTASSN-- Q640G9_XENLA Q640G9_XENLA GSGEMGTVTRICS------------------------NPPCETHETGTTQTSTTAMAN-- HCFC1_MESAU HCFC1_MESAU GTGQQRDTRHTSS---NPTVVRITVAPGALERTQGTVKPQCQTQQANMTNTTMTVQATRS HCFC1_MOUSE HCFC1_MOUSE GTGQQRDTRRTTN---TPTVVRITVAPGALERVQGTVKPQCQTQQTNMTTTTMTVQATGA B1AUX1_MOUSE B1AUX1_MOUSE GTGQQRDTRRTTN---TPTVVRITVAPGALERVQGTVKPQCQTQQTNMTTTTMTVQATGA B1AUX2_MOUSE B1AUX2_MOUSE GTGQQRDTRRTTN---TPTVVRITVAPGALERVQGTVKPQCQTQQTNMTTTTMTVQATGA B2KII8_RHIFE B2KII8_RHIFE GASQQRDTRHSCATTTTPAVVRVGVAAGALEGAQNSVKASCQTRQTSATSTTMTVMATGA B7NZP5_RABIT B7NZP5_RABIT GASQQRDARRACA-TSTPAVVRIGVAAGGSEGAQGSVKPQCQTRQTSATSTTMTVMATGV B5FW89_OTOGA B5FW89_OTOGA GTSQQRDTRRVCV-ASNPTVVRISVSTGAVEGAQVS-KPQCQTRQTSATSTTMTVMATGA B0KWV2_CALJA B0KWV2_CALJA GASHQRDARRACV-AGTPAVIRISVAAGALEAAQGS-KPQCQTRQTSATSTTMTVMATGA B1MTW3_CALMO B1MTW3_CALMO GANHQRDARRACV-AGTPAVIRISVATGALEAAQGS-KPQCQTRQTSVTSTTMTVMASGA A9CB52_PAPAN A9CB52_PAPAN GANHQRDARRACA-AGTPAVIRISVATGALEAAQGS-KPQCQTRQTSTTSTTMTVMATGA A6NEM2_HUMAN A6NEM2_HUMAN GANHQRDARRACA-AGTPAVIRISVATGALEAAQGS-KSQCQTRQTSATSTTMTVMATGA HCFC1_HUMAN HCFC1_HUMAN GANHQRDARRACA-AGTPAVIRISVATGALEAAQGS-KSQCQTRQTSATSTTMTVMATGA MATCH *: . :. .:. * *: *. :. CONSENSUS G???????????????????????????????????????????????T?T??T??????

A8WIP5_DANRE A8WIP5_DANRE SDQTGTVQSSNKSQAAISSTMMPVSSSESPGDTD-TSDVSGSVC------SNPPCETRET A5D6R2_DANRE A5D6R2_DANRE ------------------------------------------------------------ Q7SZY1_DANRE Q7SZY1_DANRE ------------------------------------------------------------ Q640G9_XENLA Q640G9_XENLA -------------MDSG------------------QGESSKKIC------SNPPCETHET HCFC1_MESAU HCFC1_MESAU PCPAGPLLRPSVALEAGNHSPAFVQLALPSVRVGLSGPSNKDMP------TGHQLETYHT HCFC1_MOUSE HCFC1_MOUSE PCSAGPLLRPSVALESGSHSPAFVQLALPSVRVGLSGPSSKDMP------TARQPETYHT B1AUX1_MOUSE B1AUX1_MOUSE PCSAGPLLRPSVALESGSHSPAFVQLALPSVRVGLSGPSSKDMP------TGRQPETYHT B1AUX2_MOUSE B1AUX2_MOUSE PCSAGPLLRPSVALESGSHSPAFVQLALPSVRVGLSGPSSKDMP------TGRQPETYHT B2KII8_RHIFE B2KII8_RHIFE PCSASPLLGPGLALEAGGHGTAFVQLAPASGQVRPSGPSGKDSPVAGLVSTGHQLEAHHS B7NZP5_RABIT B7NZP5_RABIT PYSAGPLLGPSMALEAGGHGTTFVQLAPLSSRVGPGGAGSKNVP------LGRQLETLHI B5FW89_OTOGA B5FW89_OTOGA PRSAGSFL--------GAHSPAFVQLASL---------SSKDMP------VGLQLETPHA B0KWV2_CALJA B0KWV2_CALJA PCSAGPLLGPSMAREPGGRGTAFVQLAPLSSKVRLSSPGSKDLP------T-----GRHS B1MTW3_CALMO B1MTW3_CALMO PCLAGPLLGPSVAREPGGRGTAFVQLAPLSSKVRLSSPGSKDLP------T-----GRHS A9CB52_PAPAN A9CB52_PAPAN PCSAGPLLGPSMAREPGGRGPAFVQLAPLSSKVRLSSPGSKDLP------A-----GRHS A6NEM2_HUMAN A6NEM2_HUMAN PCSAGPLLGPSMAREPGGRSPAFVQLAPLSSKVRLSSPSIKDLP------A-----GRHS HCFC1_HUMAN HCFC1_HUMAN PCSAGPLLGPSMAREPGGRSPAFVQLAPLSSKVRLSSPSIKDLP------A-----GRHS MATCH CONSENSUS ????????????????????????????????????????????????????????????

A8WIP5_DANRE A8WIP5_DANRE GTTSTPTQSSADMESGQSGSVQRVCSNPPCETHETGTTNTSTQASSSMA-AGQSGTAQRV A5D6R2_DANRE A5D6R2_DANRE -----------------MGTA-------------------------------PAGTVQRV Q7SZY1_DANRE Q7SZY1_DANRE -----------------MGTA-------------------------------PAGTVQRV Q640G9_XENLA Q640G9_XENLA GTTPTATTARSNIGKEQTDNTQRL-SKPPCETMQTVSTHTVMTVP-------DSFTSGLT HCFC1_MESAU HCFC1_MESAU YTTNTPTTALSIMGAGELGTARLI-PTSTYESLQASSPSSTMTMTALEALLCPSATVTQV HCFC1_MOUSE HCFC1_MOUSE YTTNTPTTTRSIMVAGELGAARVV-PTSTYESLQASSPSSTMTMTALEALLCPSATVTQV B1AUX1_MOUSE B1AUX1_MOUSE YTTNTPTTTRSIMVAGELGAARVV-PTSTYESLQASSPSSTMTMTALEALLCPSATVTQV B1AUX2_MOUSE B1AUX2_MOUSE YTTNTPTTTRSIMVAGELGAARVV-PTSTYESLQASSPSSTMTMTALEALLCPSATVTQV B2KII8_RHIFE B2KII8_RHIFE HNISTPSTACSSMGAGEPGEMRGL-PTHAYES----SASAPVTVTALEALLGSSTTVTQV B7NZP5_RABIT B7NZP5_RABIT HTSNSPAVVRGP-------------LTPVYDSLQSSSPSTTVTVTALEALLCPSATVTQV B5FW89_OTOGA B5FW89_OTOGA HTASTLTTAHPMLSVGELGAAQGA-PAPAYES---SPPSTTVTVTALEALLCPSGTVTQV B0KWV2_CALJA B0KWV2_CALJA HAANTATMARS-----SVGAGEPR-AAPVCESLQGGSPSTTVTVTALEALLCPSASVTQV B1MTW3_CALMO B1MTW3_CALMO HAANTAAMARS-----SVGAAEPH-AAPVCESLPGGSPGTTVTVTALEALLCPSATVTQV A9CB52_PAPAN A9CB52_PAPAN HVANTTAMARS-----SMGAGEPR-TAPACESLQGGSPSTTVTVTALEALLCPSATVTQV A6NEM2_HUMAN A6NEM2_HUMAN HAVSTAAMTRS-----SVGAGEPR-MAPVCESLQGGSPSTTVTVTALEALLCPSATVTQV HCFC1_HUMAN HCFC1_HUMAN HAVSTAAMTRS-----SVGAGEPR-MAPVCESLQGGSPSTTVTVTALEALLCPSATVTQV MATCH : : . CONSENSUS ????????????????????????????????????????????????????????????

A8WIP5_DANRE A8WIP5_DANRE CSNPPCETHETGTTNTPTQASSSLGAGQSGTVQRVCSNPPCETHETGTTNTPTQASSSLG A5D6R2_DANRE A5D6R2_DANRE CSNPPCETHETGTTNTATTASSNMGGNQPGAVQRVCSNPPCETHETGTTNTATTASSSMG Q7SZY1_DANRE Q7SZY1_DANRE CSNPPCETHETGTTNTATTASSNMGGNQPGAVQRVCSNPPCETHETGTTNTATTASSSMG Q640G9_XENLA Q640G9_XENLA SSNLPCETHETNITSTTTDVTANVGTDQSQNVVNVCSDPRSETYETGTINTPTTARSNIG HCFC1_MESAU HCFC1_MESAU CSNPPCETHETGTTNTAT--TSNAGSAQ-----RVCSNPPCETHETGTTHTATTATSNGG HCFC1_MOUSE HCFC1_MOUSE CSNPPCETHETGTTNTAT--TSNAGSAQ-----RVCSNPPCETHETGTTHTATTATSNGG B1AUX1_MOUSE B1AUX1_MOUSE CSNPPCETHETGTTNTAT--TSNAGSAQ-----RVCSNPPCETHETGTTHTATTATSNGG B1AUX2_MOUSE B1AUX2_MOUSE CSNPPCETHETGTTNTAT--TSNAGSAQ-----RVCSNPPCETHETGTTHTATTATSNGG B2KII8_RHIFE B2KII8_RHIFE CSNPPCETHETGTTNTAT--TSNAGSAQ-----RVCSNPPCETHETGTTHTPTTATSGGG B7NZP5_RABIT B7NZP5_RABIT CSNPPCETHETGTTNTAT--TSNAGSAQ-----RVCSNPPCETHETGTTHTATTATSNGG B5FW89_OTOGA B5FW89_OTOGA CSNPPCETHETGTTHTAT--TSHAGSSQ-----RVCSNPPCETHETGTTHTATTATSSGG B0KWV2_CALJA B0KWV2_CALJA CSNPPCETHETGTTNTAT--TSNAGSAQ-----RVCSNPPCETHETGTTHTATTATSNGG B1MTW3_CALMO B1MTW3_CALMO CSNPPCETHETGTTNTAT--TSNAGSAQ-----RVCSNPPCETHETGTTHTATTATSNGG A9CB52_PAPAN A9CB52_PAPAN CSNPPCETHETGTTNTAT--TSNAGSAQ-----RVCSNPPCETHETGTTHTATTATSNGG A6NEM2_HUMAN A6NEM2_HUMAN CSNPPCETHETGTTNTAT--TSNAGSAQ-----RVCSNPPCETHETGTTHTATTATSNGG HCFC1_HUMAN HCFC1_HUMAN CSNPPCETHETGTTNTAT--TSNAGSAQ-----RVCSNPPCETHETGTTHTATTATSNGG MATCH .** *******. * *.* :: * * .***:* .**:**** :*.* * *. * CONSENSUS ?SN?PCETHET??T?T?T??????G??Q??????VCS?P??ET?ETGT??T?T?A?S??G

A8WIP5_DANRE A8WIP5_DANRE AGQSGTVQRVCSNPPCETHETGTTNTQTQA-------SSTLGAGQS----GAVQRVCSNP A5D6R2_DANRE A5D6R2_DANRE GGQEGTVQRVCSNPPCETHETGTTNTATT--------SSSNMGGDQ-------------- Q7SZY1_DANRE Q7SZY1_DANRE GGQEGTVQRVCSNPPCETHETGTTNTATT--------SSSNMGGDQ-------------- Q640G9_XENLA Q640G9_XENLA SGQTENANET----PCETHQVTSTQTRMTISESNKVPSSSSEANDIVEDNQTGSSVCSNP HCFC1_MESAU HCFC1_MESAU AGQPEGGQQPAGGRPCETHQTTSTGTTMSVSVGALLPDATPSHGTL----ESGLEVVAVS HCFC1_MOUSE HCFC1_MOUSE AGQPEGGQQPASGHPCETHQTTSTGTTMSVSVGTLIPDATSSHGTL----ESGLEVVAVP B1AUX1_MOUSE B1AUX1_MOUSE AGQPEGGQQPASGHPCETHQTTSTGTTMSVSVGTLIPDATSSHGTL----ESGLEVVAVP B1AUX2_MOUSE B1AUX2_MOUSE AGQPEGGQQPASGHPCETHQTTSTGTTMSVSVGTLIPDATSSHGTL----ESGLEVVAVP B2KII8_RHIFE B2KII8_RHIFE AGQPEHGQQPPAGRPCETHQTTSTGTTMSVSMGTLLPDSAPSHRTL----ESSLEGAAPP B7NZP5_RABIT B7NZP5_RABIT AGQPEGGQQPPTSRPCETHQTTSTGTTMSVSVGALLPDATASHRTL----ESSLEVTAPP B5FW89_OTOGA B5FW89_OTOGA TGHPEGGQQAPAGHPCETHQTTSTGTTMSVSVGALLPDATPSHRTL----ESDLEVAAGP B0KWV2_CALJA B0KWV2_CALJA TGQAEGGQQPPAGRPCETHQTTSTGTTMSIGAGALLPDATSSRRTL----ESGLEAAAVP B1MTW3_CALMO B1MTW3_CALMO TGQAEGGQQPPAGRPCETHQTTSTGTTMSVSAGTLLPDATSSHRTL----ESGLEAVAAP A9CB52_PAPAN A9CB52_PAPAN TGQPEGGQQPPAGHPCETHQTTSTGTTMSVSMGALLPDATSSHRTL----ESGLEVAAAP A6NEM2_HUMAN A6NEM2_HUMAN TGQPEGGQQPPAGRPCETHQTTSTGTTMSVSVGALLPDATSSHRTV----ESGLEVAAAP HCFC1_HUMAN HCFC1_HUMAN TGQPEGGQQPPAGRPCETHQTTSTGTTMSVSVGALLPDATSSHRTV----ESGLEVAAAP MATCH *: :. *****:. :* * .:: CONSENSUS ?G????????????PCETH????T?T??????????????????????????????????

A8WIP5_DANRE A8WIP5_DANRE RETHE-----------------------------------TGTTNTPTQASSGIGAGQNG A5D6R2_DANRE A5D6R2_DANRE ----------------------------------------AG------------------ Q7SZY1_DANRE Q7SZY1_DANRE ----------------------------------------AG------------------ Q640G9_XENLA Q640G9_XENLA SCETHETNTTNTSTTSRSNIGAEQAANIQQLSKNTDQVISAGSTKTEPNILEQRVCSNPP HCFC1_MESAU HCFC1_MESAU TVTSQ-----------------------------------AGATLLASF----------- HCFC1_MOUSE HCFC1_MOUSE TVTSQ-----------------------------------AGSTLLASF----------- B1AUX1_MOUSE B1AUX1_MOUSE TVTSQ-----------------------------------AGSTLLASF----------- B1AUX2_MOUSE B1AUX2_MOUSE TVTSQ-----------------------------------AGSTLLASF----------- B2KII8_RHIFE B2KII8_RHIFE TVAPQ-----------------------------------AGASLLTPF----------- B7NZP5_RABIT B7NZP5_RABIT TVTQQ-----------------------------------ASATLLAPF----------- B5FW89_OTOGA B5FW89_OTOGA SVTPQ-----------------------------------ASTALLAPF----------- B0KWV2_CALJA B0KWV2_CALJA NVTPQ-----------------------------------AGTVLLAPF----------- B1MTW3_CALMO B1MTW3_CALMO SVTPQ-----------------------------------AGTVLLAPF----------- A9CB52_PAPAN A9CB52_PAPAN SVTPQ-----------------------------------AGTALLAPF----------- A6NEM2_HUMAN A6NEM2_HUMAN SVTPQ-----------------------------------AGTALLAPF----------- HCFC1_HUMAN HCFC1_HUMAN SVTPQ-----------------------------------AGTALLAPF----------- MATCH :. CONSENSUS ????????????????????????????????????????????????????????????

A8WIP5_DANRE A8WIP5_DANRE --------------------------TVQMVCSNPPCETHETGTTNTATTATSNLETGEG A5D6R2_DANRE A5D6R2_DANRE --------------------------AVQRVCSNPPCETHETGTTNTATTATCNMETDEG Q7SZY1_DANRE Q7SZY1_DANRE --------------------------AVQRVCSNPPCETHETGTTNTATTATCNMETDEG Q640G9_XENLA Q640G9_XENLA CETHETNTTNTATTSTSNIDNQPTAPPTQQVCSNPPCETHETGTTHTATTVTASMGTNED HCFC1_MESAU HCFC1_MESAU --------------------------PTQRVCSNPPCETHETGTTHTATTVTSNMSSNQD HCFC1_MOUSE HCFC1_MOUSE --------------------------PTQRVCSNPPCETHETGTTHTATTVTSNMSSNQD B1AUX1_MOUSE B1AUX1_MOUSE --------------------------PTQRVCSNPPCETHETGTTHTATTVTSNMSSNQD B1AUX2_MOUSE B1AUX2_MOUSE --------------------------PTQRVCSNPPCETHETGTTHTATTVTSNMSSNQD B2KII8_RHIFE B2KII8_RHIFE --------------------------PTQRVCSNPPCETHETGTTHTATTVTSNMSSNQD B7NZP5_RABIT B7NZP5_RABIT --------------------------PTQRVCSNPPCETHETGTTHTATTVTSNMSSNQD B5FW89_OTOGA B5FW89_OTOGA --------------------------PTQRVCSNPPCETHETGTTHTATTVTSNMSSNQD B0KWV2_CALJA B0KWV2_CALJA --------------------------PTQRVCSNPPCETHETGTTHTATTVTSNMSSNQD B1MTW3_CALMO B1MTW3_CALMO --------------------------PTQRVCSNPPCETHETGTTHTATTVTSNMSSNQD A9CB52_PAPAN A9CB52_PAPAN --------------------------PTQRVCSNPPCETHETGTTHTATTVTSNMSSNQD A6NEM2_HUMAN A6NEM2_HUMAN --------------------------PTQRVCSNPPCETHETGTTHTATTVTSNMSSNQD HCFC1_HUMAN HCFC1_HUMAN --------------------------PTQRVCSNPPCETHETGTTHTATTVTSNMSSNQD MATCH ..* ***************:****.*..: :.:. CONSENSUS ????????????????????????????Q?VCSNPPCETHETGTT?TATT?T????????

A8WIP5_DANRE A8WIP5_DANRE AAQQAGDGQSESATSTE----------------------PTSSTEPANPATQS---RAIT A5D6R2_DANRE A5D6R2_DANRE TAQQTSEASESSTSTE-----SLPAT-------------AAA---------QR---GAIT Q7SZY1_DANRE Q7SZY1_DANRE TAA------------------------------------------------QR---GAIT Q640G9_XENLA Q640G9_XENLA QPPASGEEEEQQSEQADESIQSSNISTGSSSSPVTIVAVAATASSSPVHSTVPAVSRAVT HCFC1_MESAU HCFC1_MESAU PPPAASDQGEVVSTQGD----SANIT-------------SSSGITTTVSSTLP---RAVT HCFC1_MOUSE HCFC1_MOUSE PPPAASDQGEVASTQGD----STNIT-------------SASAITTSVSSTLP---RAVT B1AUX1_MOUSE B1AUX1_MOUSE PPPAASDQGEVASTQGD----STNIT-------------SASAITTSVSSTLP---RAVT B1AUX2_MOUSE B1AUX2_MOUSE PPPAASDQGEVASTQGD----STNIT-------------SASAITTSVSSTLP---RAVT B2KII8_RHIFE B2KII8_RHIFE PPPAASDQGEVESTEGD----SVNIT-------------SSSAITTTVSSTLT---RAVT B7NZP5_RABIT B7NZP5_RABIT PPPAASDQGEVESSQGD-----VSIT-------------SAGAITTTVSATLP---RAVT B5FW89_OTOGA B5FW89_OTOGA PPPAASDQGEVESTQGD------NVN-------------NSSAITTTVSSTLT---RAVT B0KWV2_CALJA B0KWV2_CALJA TPPTTSDQGEVESTQGD----SVNIT-------------SSSAITTTVSSTLT---RAVT B1MTW3_CALMO B1MTW3_CALMO TPPATSDQGEVESTQGD----SVNIT-------------SSSAITTTVSSTLT---RAVT A9CB52_PAPAN A9CB52_PAPAN PPPAASDQGEVESTQGD----SVNIT-------------SSSAITTTVSSTLT---RAVT A6NEM2_HUMAN A6NEM2_HUMAN PPPAASDQGEVESTQGD----SVNIT-------------SSSAITTTVSSTLT---RAVT HCFC1_HUMAN HCFC1_HUMAN PPPAASDQGEVESTQGD----SVNIT-------------SSSAITTTVSSTLT---RAVT MATCH . *:* CONSENSUS ?????????????????????????????????????????????????????????A?T

A8WIP5_DANRE A8WIP5_DANRE TVTQATPTPGPSVPEISSMAGSA-----------------------------------VV A5D6R2_DANRE A5D6R2_DANRE TVTQATPLPGPAVPSISSITESSSEAGAEPVVMESSEAESLQTEGQAEAEAVA-----MQ Q7SZY1_DANRE Q7SZY1_DANRE TVTQATPLPGPAVPSISSITESSSEAGAEPVVMESSEAESLQTEGQAEAEAVA-----MQ Q640G9_XENLA Q640G9_XENLA TVTQSRQLPGPSVPNISSITE-------------------------------------PS HCFC1_MESAU HCFC1_MESAU TVTQSTPVPGPSVPNISSLTE-TPGALTSEVPIPATITVTIANTETSDMPFSAVDILQPP HCFC1_MOUSE HCFC1_MOUSE TVTQSTPVPGPSVP--------------------------------------------PP B1AUX1_MOUSE B1AUX1_MOUSE TVTQSTPVPGPSVP--------------------------------------------PP B1AUX2_MOUSE B1AUX2_MOUSE TVTQSTPVPGPSVPNISSLTETTPGALNSEVPIPATITVTIANTETSDMPFSAVDILQPP B2KII8_RHIFE B2KII8_RHIFE TVTQSTPAPGPSVP--------------------------------------------PP B7NZP5_RABIT B7NZP5_RABIT TVTQSTPVPGPSVP--------------------------------------------PP B5FW89_OTOGA B5FW89_OTOGA TVTQSTPVPGPSVP--------------------------------------------PP B0KWV2_CALJA B0KWV2_CALJA TVTQSTPVPGPSVP--------------------------------------------PP B1MTW3_CALMO B1MTW3_CALMO TVTQSTPVPGPSVP--------------------------------------------PP A9CB52_PAPAN A9CB52_PAPAN TVTQSTPVPGPSVP--------------------------------------------PP A6NEM2_HUMAN A6NEM2_HUMAN TVTQSTPVPGPSVPKISSMTETAPRALTTEVPIPAKITVTIANTETSDMPFSAVDILQPP HCFC1_HUMAN HCFC1_HUMAN TVTQSTPVPGPSVP--------------------------------------------PP MATCH ****: ***:** CONSENSUS TVTQ????PGP?VP??????????????????????????????????????????????

A8WIP5_DANRE A8WIP5_DANRE SETPGEAEAMEQASAEAVAAGEEPMQTESQGELSEEGAVRVVAIDESAAGDGSTVLQVHV A5D6R2_DANRE A5D6R2_DANRE AEFQTEAGAVAL--PTDFQEDAAALPADFQGE-----AVAVAMQAESQADAVP--MEQDV Q7SZY1_DANRE Q7SZY1_DANRE AEFQTEAGAVAL--PTDFQEDAAALPADFQGE-----AVAVAMQAESQADAVP--MEQDV Q640G9_XENLA Q640G9_XENLA SDVAVQ-GSEAVSCPEQSKAPLS---SDILQP-----SKDV--QSEAEALQQPMDSAVPE HCFC1_MESAU HCFC1_MESAU EELQVSPGPRQQLPPRQLLQSAS---TPLMGE-----SSEV--LSASQTPELQ--AAVDL HCFC1_MOUSE HCFC1_MOUSE EELQVSPGPRQQLPPRQLLQSAS---TPLMGE-----STEV--LSASQTPELQ--AAVDL B1AUX1_MOUSE B1AUX1_MOUSE EELQVSPGPRQQLPPRQLLQSAS---TPLMGE-----STEV--LSASQTPELQ--AAVDL B1AUX2_MOUSE B1AUX2_MOUSE EELQVSPGPRQQLPPRQLLQSAS---TPLMGE-----STEV--LSASQTPELQ--AAVDL B2KII8_RHIFE B2KII8_RHIFE EELQASPGPRQQLPPRQLLQPAS---TPLMGE-----SADV--LSASQTPELQ--TAVDL B7NZP5_RABIT B7NZP5_RABIT EELQVSPGPRQQLPPRQLLQSAS---TPLMGE-----STEV--LSASQTPELQ--AAVDL B5FW89_OTOGA B5FW89_OTOGA EELQVSPGPRSQLPPRQLLQSAS---TPLMGE-----STEV--LSASQTPELP--DAVDL B0KWV2_CALJA B0KWV2_CALJA EELQVSPGPRQQLPPRQLLQSAS---TALMGE-----SAEV--LSASQTPELP--AAVDL B1MTW3_CALMO B1MTW3_CALMO EELQVSPGPRQQLPPRQLLQSAS---TALMGE-----SAEV--LSASQTPELP--AAVDL A9CB52_PAPAN A9CB52_PAPAN EELQVSPGPRQQLPPRQLLQSAS---TALMGE-----STEV--LSASQTPELP--AAVDL A6NEM2_HUMAN A6NEM2_HUMAN EELQVSPGPRQQLPPRQLLQSAS---TALMGE-----SAEV--LSASQTPELP--AAVDL HCFC1_HUMAN HCFC1_HUMAN EELQVSPGPRQQLPPRQLLQSAS---TALMGE-----SAEV--LSASQTPELP--AAVDL MATCH : . . . : : * : : CONSENSUS ????????????????????????????????????????V???????????????????

A8WIP5_DANRE A8WIP5_DANRE AMEAQPGQG-DQAEQMEAGVEAAEAMSLAAQDSEALALPQELMSAEGQ--QTTLMVTGLT A5D6R2_DANRE A5D6R2_DANRE SGMAEGEATQEQLPTAEMEDV----DAASASQAAVLALPPELM-ADGQ--STTLMVTGLT Q7SZY1_DANRE Q7SZY1_DANRE SGMAEGEAAQEQLPTAEMEDV----DAASASQAAVLALPPELM-ADGQ--STTLMVTGLT Q640G9_XENLA Q640G9_XENLA HNAAELHAAIEAESSQNAAVA------AEQHAVEQLSLPQELM-AEGQ--TTTLMVTGLT HCFC1_MESAU HCFC1_MESAU SSTGDPSSGQEPTSSAVVATVVVQPPPPTQSEVDQLSLPQELM-AEAQAGTTTLMVTGLT HCFC1_MOUSE HCFC1_MOUSE SSTGDPSSGQEPTTSAVVATVVVQPPPPTQSEVDQLSLPQELM-AEAQAGTTTLMVTGLT B1AUX1_MOUSE B1AUX1_MOUSE SSTGDPSSGQEPTTSAVVATVVVQPPPPTQSEVDQLSLPQELM-AEAQAGTTTLMVTGLT B1AUX2_MOUSE B1AUX2_MOUSE SSTGDPSSGQEPTTSAVVATVVVQPPPPTQSEVDQLSLPQELM-AEAQAGTTTLMVTGLT B2KII8_RHIFE B2KII8_RHIFE SSTGDPSSGQEPANSAVVATVVVQPPPPTQSEVDQLSLPQELM-AEAQAGTTTLMVTGLT B7NZP5_RABIT B7NZP5_RABIT SSTGDPSSGQEPTSSAVVATVVVQPPPPTQSEVDQLSLPQELM-AEAQAGTTTLMVTGLT B5FW89_OTOGA B5FW89_OTOGA SSTGDPSSGQEPASSAVVATVVVQPPPPTQSEVDQLSLPQELM-AETQAGTTTLMVTGLT B0KWV2_CALJA B0KWV2_CALJA SSTGEPSSGQESASSAVVATVVVQPPPPAQPEVDQLSLPQELM-AEAQAGTTTLMVTGLT B1MTW3_CALMO B1MTW3_CALMO SSTGEPSSGQESASSAVVATVVVQPPPPAQSEVDQLSLPQELM-AEAQAGTTTLMVTGLT A9CB52_PAPAN A9CB52_PAPAN SSTGEPSSGQESASSAVVATVVVQPPPPAQSEVDQLSLPQELM-AEAQAGTTTLMVTGLT A6NEM2_HUMAN A6NEM2_HUMAN SSTGEPSSGQESAGSAVVATVVVQPPPPTQSEVDQLSLPQELM-AEAQAGTTTLMVTGLT HCFC1_HUMAN HCFC1_HUMAN SSTGEPSSGQESAGSAVVATVVVQPPPPTQSEVDQLSLPQELM-AEAQAGTTTLMVTGLT MATCH .: : *:** *** *: * ********* CONSENSUS ???????????????????????????????????L?LP?ELM?A??Q???TTLMVTGLT

A8WIP5_DANRE A8WIP5_DANRE PEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVLSG----EGD------------ A5D6R2_DANRE A5D6R2_DANRE PEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVMSD------------------- Q7SZY1_DANRE Q7SZY1_DANRE PEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVMSD------------------- Q640G9_XENLA Q640G9_XENLA PEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVM-GFQAASGEPMDTSD----VA HCFC1_MESAU HCFC1_MESAU PEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVMAG----TGEPMDTSEAAAAVT HCFC1_MOUSE HCFC1_MOUSE PEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVM-G----TGEPMDTSEAAAAVT B1AUX1_MOUSE B1AUX1_MOUSE PEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVM-G----TGEPMDTSEAAAAVT B1AUX2_MOUSE B1AUX2_MOUSE PEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVMAG----TGEPMDTSEAAAAVT B2KII8_RHIFE B2KII8_RHIFE PEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVM-G----TGEPMDTSEAAAAVT B7NZP5_RABIT B7NZP5_RABIT PEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVM-G----TGEPMDTSEAAAAVT B5FW89_OTOGA B5FW89_OTOGA PEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVM-G----TGEPMDTSEAAAAVT B0KWV2_CALJA B0KWV2_CALJA PEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVM-G----TGEPMDTSEAAATVT B1MTW3_CALMO B1MTW3_CALMO PEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVM-G----TGEPMDTSEAAATVT A9CB52_PAPAN A9CB52_PAPAN PEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVM-G----TGEPMDTSEAAATVT A6NEM2_HUMAN A6NEM2_HUMAN PEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVMAG----TGEPMDTSEAAATVT HCFC1_HUMAN HCFC1_HUMAN PEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVM-G----TGEPMDTSEAAATVT MATCH **************************************: . CONSENSUS PEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAV??????????????????????

A8WIP5_DANRE A8WIP5_DANRE --------AGHDGQQATTIPIVLTQQELAALVQQQ------------------QQLQEAQ A5D6R2_DANRE A5D6R2_DANRE --------AGGDDQQTHTIPIVLTQQELAALVQQQ------------------QQLQAAQ Q7SZY1_DANRE Q7SZY1_DANRE --------AGGDDQQTHTIPIVLTQQELAALVQQQ------------------QQLQAAQ Q640G9_XENLA Q640G9_XENLA HAELRHLTT---EGPTTTIPIVLTQQELAALVQQQQLQEQQQIQQHQLQQQQLQQLQQQQ HCFC1_MESAU HCFC1_MESAU QAELGHLSAEGQEGQATTIPIVLTQQELAALVQQQ------------------QQLQEVQ HCFC1_MOUSE HCFC1_MOUSE QAELGHLSAEGQEGQATTIPIVLTQQELAALVQQQ------------------QQLQEAQ B1AUX1_MOUSE B1AUX1_MOUSE QAELGHLSAEGQEGQATTIPIVLTQQELAALVQQQ------------------QQLQEAQ B1AUX2_MOUSE B1AUX2_MOUSE QAELGHLSAEGQEGQATTIPIVLTQQELAALVQQQ------------------QQLQEAQ B2KII8_RHIFE B2KII8_RHIFE QAELGHLAAEGQEGQATTIPIVLTQQELAALVQQQ------------------QQLQEAQ B7NZP5_RABIT B7NZP5_RABIT QAELGHLSAEGQEGQATTIPIVLTQQELAALVQQQ------------------QQLQEAQ B5FW89_OTOGA B5FW89_OTOGA QAELGHLSAEGQEGQATTIPIVLTQQELAALVQQQ------------------QQLQEAQ B0KWV2_CALJA B0KWV2_CALJA QAELGHLSAEGQEGQATTIPIVLTQQELAALV-QQ------------------QQLQEAQ B1MTW3_CALMO B1MTW3_CALMO QAELGHLSAEGQEGQATTIPIVLTQQELAALV-QQ------------------QQLQEAQ A9CB52_PAPAN A9CB52_PAPAN QAELGHLSAEGQEGQATTIPIVLTQQELAALV-QQ------------------QQLQEAQ A6NEM2_HUMAN A6NEM2_HUMAN QAELGHLSAEGQEGQATTIPIVLTQQELAALV-QQ------------------QQLQEAQ HCFC1_HUMAN HCFC1_HUMAN QAELGHLSAEGQEGQATTIPIVLTQQELAALV-QQ------------------QQLQEAQ MATCH : : *************** ** **** * CONSENSUS ?????????????????TIPIVLTQQELAALV?QQ??????????????????QQLQ??Q

A8WIP5_DANRE A8WIP5_DANRE AAAAQQLSAEAAA-----AALPTEGLAPADSLNDPASESNGH-EMPTAVTGAVVRLLPRT A5D6R2_DANRE A5D6R2_DANRE QQAAAQ------------AALPTEGLAPADSLNDPLSESNGHNEMAAAATSAVVTLLPRT Q7SZY1_DANRE Q7SZY1_DANRE QQAAAQ------------AALPTEGLAPADSLNDPLSESNGHNEMAAAATSAVVTLLPRT Q640G9_XENLA Q640G9_XENLA LQQQQQLHQQQLQHLQQLHHVPTEALAPADSLNDPASESNGLSELTSAVTNA-VALLPTT HCFC1_MESAU HCFC1_MESAU AQAQQQ------------HHLPTEALAPADSLNDPSIESNCLNELASAVPST-VALLPST HCFC1_MOUSE HCFC1_MOUSE AQAQQQ------------HHLPTEALAPADSLNDPSIESNCLNELASAVPST-VALLPST B1AUX1_MOUSE B1AUX1_MOUSE AQAQQQ------------HHLPTEALAPADSLNDPSIESNCLNELASAVPST-VALLPST B1AUX2_MOUSE B1AUX2_MOUSE AQAQQQ------------HHLPTEALAPADSLNDPSIESNCLNELASAVPST-VALLPST B2KII8_RHIFE B2KII8_RHIFE AQ-QQQ------------HHLPTEALAPADSLNDPAIEGNCLSELAGAVPST-VALLPST B7NZP5_RABIT B7NZP5_RABIT AQAQQQ-------------HLPTEALAPADSLNDPTIESNCLSELAGAVPST-VALLPST B5FW89_OTOGA B5FW89_OTOGA AQ-QQH------------HHLPTEALAPADSLNDPTIESNCLNELAGAVPST-VALLPST B0KWV2_CALJA B0KWV2_CALJA AQ-QQH------------HHLPTEALAPADSLNDPAIESNCLNELAGTVPST-VALLPST B1MTW3_CALMO B1MTW3_CALMO A---QH------------HHLPTEALAPADSLNDPAIESNCLNELAGTVPST-VALLPST A9CB52_PAPAN A9CB52_PAPAN AQ-QQH------------HHLPTEALAPADSLNDPAIESNCLNELAGTVPST-VALLPST A6NEM2_HUMAN A6NEM2_HUMAN AQ-QQH------------HHLPTEALAPADSLNDPAIESNCLNELAGTVPST-VALLPST HCFC1_HUMAN HCFC1_HUMAN AQ-QQH------------HHLPTEALAPADSLNDPAIESNCLNELAGTVPST-VALLPST MATCH : :***.********** *.* *:. :...: * *** * CONSENSUS ?????????????????????PTE?LAPADSLNDP??E?N???E?????????V?LLP?T

A8WIP5_DANRE A8WIP5_DANRE SAETLAPSSTFAPSQPLVVASPAKMQAATALAEVANGIESAAGKQEAPPVVVKPPVKKEN A5D6R2_DANRE A5D6R2_DANRE AAETLAPSSTLA---PVVVASPAKMQAAAALTEVANGIEAGKQNP--PTVTVKPQVKKEN Q7SZY1_DANRE Q7SZY1_DANRE AAETLAPSSTLA---PVVVASPAKMQAAAALTEVANGIEAGKQNP--PTVTVKPQVKKEN Q640G9_XENLA Q640G9_XENLA ATDNLTVSNTFTAPQPVVIASPAKLQAAAALTEVANGIES---KQDSPPQQAKAPVKKEN HCFC1_MESAU HCFC1_MESAU ATESLAPSNTFVAPQPVVVASPAKMQAAATLTEVDNGIESLGVKPDLPPPPSKAPVKKEN HCFC1_MOUSE HCFC1_MOUSE ATESLAPSNTFVAPQPVV-ASPAKMQAAATLTEVANGIESLGVKPDLPPPPSKAPVKKEN B1AUX1_MOUSE B1AUX1_MOUSE ATESLAPSNTFVAPQPVV-ASPAKMQAAATLTEVANGIESLGVKPDLPPPPSKAPVKKEN B1AUX2_MOUSE B1AUX2_MOUSE ATESLAPSNTFVAPQPVV-ASPAKMQAAATLTEVANGIESLGVKPDLPPPPSKAPVKKEN B2KII8_RHIFE B2KII8_RHIFE ATESLAPSNTFVAPQPVVGASPAKLQAAATLTEVANGIESLGVKPDLPPPPSKAPVKKEN B7NZP5_RABIT B7NZP5_RABIT ATESLAPSNTFVAPQPVVVASPAKLQAAATLTEVANGIESLGVKPDLPPPPSKAPVKKEN B5FW89_OTOGA B5FW89_OTOGA ATESLAPSNTFVAPQPVVVASPAKLQAAATLTEVANGIESLGVKQDLPPPPSKAPVKKEN B0KWV2_CALJA B0KWV2_CALJA ATESLAPSNTFVAPQPVVVASPAKLQAAATLTEVANGIESLGVKPDLPPPPSKAPMKKEN B1MTW3_CALMO B1MTW3_CALMO ATESLAPSNTFVAPQPVVVASQAKLQAAATLTEVANGIESLGVKPDLPPPPSKAPMKKEN A9CB52_PAPAN A9CB52_PAPAN ATESLAPSNTFVAPQPVVVASPAKLQAAATLTEVANGIESLGVKPDLPPPPSKAPMKKEN A6NEM2_HUMAN A6NEM2_HUMAN ATESLAPSNTFVAPQPVVVASPAKLQAAATLTEVANGIESLGVKPDLPPPPSKAPMKKEN HCFC1_HUMAN HCFC1_HUMAN ATESLAPSNTFVAPQPVVVASPAKLQAAATLTEVANGIESLGVKPDLPPPPSKAPMKKEN MATCH :::.*: *.*:. *:* ** **:***::*:** ****: : *. *. :**** CONSENSUS ????L??S?T?????P?V?AS?AK?QAA??L?EV?NGIE????????P????K???KKEN

A8WIP5_DANRE A8WIP5_DANRE QWFDVGIVKVTNMVVTHYYVPADDSAVTDDDSGAIPDYSRMKKIELSPGTAYKFRVAGIN A5D6R2_DANRE A5D6R2_DANRE QWFDVGIVKVTNTVVTHFYMPADDSAYVENDSGTAPDYSQMKRVELQPGTAYKFRVAGIN Q7SZY1_DANRE Q7SZY1_DANRE QWFDVGIVKVTNTVVTHFYMPADDSAYVENDSGTAPDYSQMKRVELQPGTAYKFRVAGIN Q640G9_XENLA Q640G9_XENLA QWFDVGVIKATNMMVTHYYLPADDSV-NDDDSVVLPDYSQLKKQELQPGTAYKFRVAGVN HCFC1_MESAU HCFC1_MESAU QWFDVGVIKGTSVMVTHYFLPPDDAVQSDDDSGTIPDYNQLKKQELQPGTAYKFRVAGIN HCFC1_MOUSE HCFC1_MOUSE QWFDVGVIKGTSVMVTHYFLPPDDAVQSDDDSGTVPDYNQLKKQELQPGTAYKFRVAGIN B1AUX1_MOUSE B1AUX1_MOUSE QWFDVGVIKGTSVMVTHYFLPPDDAVQSDDDSGTVPDYNQLKKQELQPGTAYKFRVAGIN B1AUX2_MOUSE B1AUX2_MOUSE QWFDVGVIKGTSVMVTHYFLPPDDAVQSDDDSGTVPDYNQLKKQELQPGTAYKFRVAGIN B2KII8_RHIFE B2KII8_RHIFE QWFDVGVIKGTNVMVTHYFLPPDDAVPSDDDSGTVPDYTQLKKQELQPGTAYKFRVAGIN B7NZP5_RABIT B7NZP5_RABIT QWFDVGVIKGTNVMVTHYFLPPDDAVPSDDDSGTVPDYNQLKKQELQPGTAYKFRVAGIN B5FW89_OTOGA B5FW89_OTOGA QWFDVGVIKGTNVMVTHYFLPPDDAVPSDDDSGTVPDYNQLKKQELQPGTAYKFRVAGIN B0KWV2_CALJA B0KWV2_CALJA QWFDVGVIKGTNVMVTHYFLPPDDAVPSD------------------------------- B1MTW3_CALMO B1MTW3_CALMO QWFDVGVIKGTNVMVTHYFLPPDDAIPSDDDLGTVPDYNQLKKQELQPGTAYKFRVAGIN A9CB52_PAPAN A9CB52_PAPAN QWFDVGVIKGTNVMVTHYFLPPDDAVPSDDDSGTVPDYNQLKKQELQPGTAYKFRVAGIN A6NEM2_HUMAN A6NEM2_HUMAN QWFDVGVIKGTNVMVTHYFLPPDDAVPSDDDLGTVPDYNQLKKQELQPGTAYKFRVAGIN HCFC1_HUMAN HCFC1_HUMAN QWFDVGVIKGTNVMVTHYFLPPDDAVPSDDDLGTVPDYNQLKKQELQPGTAYKFRVAGIN MATCH ******::* *. :***:::*.**: : CONSENSUS QWFDVG??K?T???VTH???P?DD????????????????????????????????????

A8WIP5_DANRE A8WIP5_DANRE ACGRGTFSEVSAFKTCLPGFPGAPCAIKISKSPDGAHLTWEPPSVTSGKIIEYSVYLAIQ A5D6R2_DANRE A5D6R2_DANRE TCGRGTFSEISAFKTCLPGFPGAPCAIKISKSPDGAHLTWEPPSVTSGKITEYSVYLAIQ Q7SZY1_DANRE Q7SZY1_DANRE TCGRGTFSEISAFKTCLPGFPGAPCAIKISKSPDGAHLTWEPPSVTSGKITEYSVYLAIQ Q640G9_XENLA Q640G9_XENLA ACGRGPYSEISAFKTCLPGFPGAPCAIKISKSPDGAHLTWEPPSVTSGKIIEYSVYLAIQ HCFC1_MESAU HCFC1_MESAU ACGRGPFSEISAFKTCLPGFPGAPCAIKISKSPDGAHLTWEPPSVTSGKIIEYSVYLAIQ HCFC1_MOUSE HCFC1_MOUSE ACGRGPFSEISAFKTCLPGFPGAPCAIKISKSPDGAHLTWEPPSVTSGKIIEYSVYLAIQ B1AUX1_MOUSE B1AUX1_MOUSE ACGRGPFSEISAFKTCLPGFPGAPCAIKISKSPDGAHLTWEPPSVTSGKIIEYSVYLAIQ B1AUX2_MOUSE B1AUX2_MOUSE ACGRGPFSEISAFKTCLPGFPGAPCAIKISKSPDGAHLTWEPPSVTSGKIIEYSVYLAIQ B2KII8_RHIFE B2KII8_RHIFE ACGRGPFSEISAFKTCLPGFPGAPCAIKISKSPDGAHLTWEPPSVTSGKIIEYSVYLAIQ B7NZP5_RABIT B7NZP5_RABIT ACGRGPFSEISAFKTCLPGFPGAPCAIKISKSPDGAHLTWEPPSVTSGKIIEYSVYLAIQ B5FW89_OTOGA B5FW89_OTOGA ACGRGPFSEISAFKTCLPGFPGAPCAIKISKSPDGAHLTWEPPSVTSGKIIEYSVYLAIQ B0KWV2_CALJA B0KWV2_CALJA --------------------------VSVRRS---------------------------- B1MTW3_CALMO B1MTW3_CALMO ACGRGPFSEISAFKTCLPGFPGAPCAIKISKSPDGAHLTWEPPSVTSGKIIEYSVYLAIQ A9CB52_PAPAN A9CB52_PAPAN ACGRGPFSEISAFKTCLPGFPGAPCAIKISKSPDGAHLTWEPPSVTSGKIIEYSVYLAIQ A6NEM2_HUMAN A6NEM2_HUMAN ACGRGPFSEISAFKTCLPGFPGAPCAIKISKSPDGAHLTWEPPSVTSGKIIEYSVYLAIQ HCFC1_HUMAN HCFC1_HUMAN ACGRGPFSEISAFKTCLPGFPGAPCAIKISKSPDGAHLTWEPPSVTSGKIIEYSVYLAIQ MATCH :.: :* CONSENSUS ???????????????????????????????S????????????????????????????

A8WIP5_DANRE A8WIP5_DANRE SSQT--VEAKASAPAQLAFMRVYCGPNPSCLVQSSSLSNAHIDYTTKPAIIFRIAARNEK A5D6R2_DANRE A5D6R2_DANRE SSQT--TEAKPSAPAQLAFMRVYCGPNPSCLVQSSSLSNAHIDYTTKPAIIFRIAARNEK Q7SZY1_DANRE Q7SZY1_DANRE SSQT--TEAKPSAPAQLAFMRVYCGPNPSCLVQSSSLSNAHIDYTTKPAIIFRIAARNEK Q640G9_XENLA Q640G9_XENLA SSQA-SGEQK-STPAQLAFMRVYCGPNPSCLVQSSSLSNAHIDYTTKPAIIFRIAARNEK HCFC1_MESAU HCFC1_MESAU SSQA-GGEPKSSTPAQLAFMRVYCGPSPSCLVQSSSLSNAHIDYTTKPAIIFRIAARNEK HCFC1_MOUSE HCFC1_MOUSE SSQA-SGEPKSSTPAQLAFMRVYCGPSPSCLVQSSSLSNAHIDYTTKPAIIFRIAARNEK B1AUX1_MOUSE B1AUX1_MOUSE SSQA-SGEPKSSTPAQLAFMRVYCGPSPSCLVQSSSLSNAHIDYTTKPAIIFRIAARNEK B1AUX2_MOUSE B1AUX2_MOUSE SSQA-SGEPKSSTPAQLAFMRVYCGPSPSCLVQSSSLSNAHIDYTTKPAIIFRIAARNEK B2KII8_RHIFE B2KII8_RHIFE SSQAGGGEPKSSTPAQLAFMRVYCGPSPSCLVQSSSLSNAHIDYTTKPAIIFRIAARNEK B7NZP5_RABIT B7NZP5_RABIT SSQA-GSEPKSSAPAQLAFMRVYCGPSPSCLVQSSSLSNAHIDYTTKPAIIFRIAARNEK B5FW89_OTOGA B5FW89_OTOGA SSQA-GGEPKSSSPAQLAFMRVYCGPSPSCLVQSSSLSNAHIDYTTKPAIIFRIAARNEK B0KWV2_CALJA B0KWV2_CALJA ------------------------------------------------------------ B1MTW3_CALMO B1MTW3_CALMO SSQA-GGELKSSTPAQLAFMRVYCGPSPSCLVQSSSLSNAHIDYTTKPAIIFRIAARNEK A9CB52_PAPAN A9CB52_PAPAN SSQA-GGELKSSTPAQLAFMRVYCGPSPSCLVQSSSLSNAHIDYTTKPAIIFRIAARNEK A6NEM2_HUMAN A6NEM2_HUMAN SSQA-GGELKSSTPAQLAFMRVYCGPSPSCLVQSSSLSNAHIDYTTKPAIIFRIAARNEK HCFC1_HUMAN HCFC1_HUMAN SSQA-GGELKSSTPAQLAFMRVYCGPSPSCLVQSSSLSNAHIDYTTKPAIIFRIAARNEK MATCH CONSENSUS ????????????????????????????????????????????????????????????

A8WIP5_DANRE A8WIP5_DANRE GYGPATQVRWLQETSKDGSAAKPAAKRPVSSPDMKGAGPKKARSDQ- A5D6R2_DANRE A5D6R2_DANRE GYGPATQVRWLQESSKDGLSAKPAPKRAVSSPDTKGIGQKKARMDQ- Q7SZY1_DANRE Q7SZY1_DANRE GYGPATQVRWLQESSKDGLSAKPAPKRAVSSPDTKGIGQKKARMDQ- Q640G9_XENLA Q640G9_XENLA GYGPATQVRWLQESNKDGSAGKPANKRPVSSPDMKTA-PKKAKSDHA HCFC1_MESAU HCFC1_MESAU GYGPATQVRWLQETSKDSSGTKPASKRPMSSPEMKSA-PKKSKADGQ HCFC1_MOUSE HCFC1_MOUSE GYGPATQVRWLQETSKDSSGTKPASKRPMSSPEMKSA-PKKSKADGQ B1AUX1_MOUSE B1AUX1_MOUSE GYGPATQVRWLQETSKDSSGTKPASKRPMSSPEMKSA-PKKSKADGQ B1AUX2_MOUSE B1AUX2_MOUSE GYGPATQVRWLQETSKDSSGTKPASKRPMSSPEMKSA-PKKSKADGQ B2KII8_RHIFE B2KII8_RHIFE GYGPATQVRWLQETSKDNSGTKPASKRPMSSPEIKSA-PKKSKADGQ B7NZP5_RABIT B7NZP5_RABIT GYGPATQVRWLQETSKDGSGSKPASKRPMSSPEMKSA-PKKSKADGQ B5FW89_OTOGA B5FW89_OTOGA GYGPATQVRWLQETSKDSSGTKPASKRPMSSPEMKSA-PKKSKADGQ B0KWV2_CALJA B0KWV2_CALJA ----------------------------------------------- B1MTW3_CALMO B1MTW3_CALMO GYGPATQVRWLQETSKDSSGTKPANKRPMSSPEMKSA-PKKSKADGQ A9CB52_PAPAN A9CB52_PAPAN GYGPATQVRWLQETSKDSSGTKPANKRPMSSPEMKSA-PKKSKADGQ A6NEM2_HUMAN A6NEM2_HUMAN GYGPATQVRWLQETSKDSSGTKPANKRPMSSPEMKSA-PKKSKADGQ HCFC1_HUMAN HCFC1_HUMAN GYGPATQVRWLQETSKDSSGTKPANKRPMSSPEMKSA-PKKSKADGQ MATCH CONSENSUS ???????????????????????????????????????????????


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