Alignment of the gene Family HBG051888 of HOVERGEN

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Isoforms are OFF
A8WIP5_DANRE A8WIP5_DANRE -----MASSGTSVLQPRWKRVLGWSGPVPRPRHGHRAVAIKELMVVFGGGNEGIVDELHV A5D6R2_DANRE A5D6R2_DANRE TSPGVPGTTGA-PLQPRWKRVLGWSGPVPRPRHGHRAVAIKELMVVFGGGNEGIVDELHV Q7SZY1_DANRE Q7SZY1_DANRE TSPGVPGTTGA-PLQPRWKRVLGWSGPVPRPRHGHRAVAIKELMVVFGGGNEGIVDELHV Q640G9_XENLA Q640G9_XENLA -MAATPALSTAGALQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHV HCFC1_MESAU HCFC1_MESAU ASAVSPANLPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHV HCFC1_MOUSE HCFC1_MOUSE ASAVSPANLPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHV B1AUX1_MOUSE B1AUX1_MOUSE ASAVSPANLPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHV B1AUX2_MOUSE B1AUX2_MOUSE ASAVSPANLPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHV B2KII8_RHIFE B2KII8_RHIFE ASAVSPANSPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHV B7NZP5_RABIT B7NZP5_RABIT ASAVSPANSPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHV B5FW89_OTOGA B5FW89_OTOGA -----------------MAMCLGRSST--------------------------------- B0KWV2_CALJA B0KWV2_CALJA ------------------------------------------------------------ B1MTW3_CALMO B1MTW3_CALMO ASAVSPANSPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHV A9CB52_PAPAN A9CB52_PAPAN ASAVSPANSPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHV A6NEM2_HUMAN A6NEM2_HUMAN ASAVSPANLPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHV HCFC1_HUMAN HCFC1_HUMAN ASAVSPANLPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHV MATCH CONSENSUS ?????P????A??LQPRWKRV?GWSGPVPRPRHGHRAVAIKEL?VVFGGGNEGIVDELHV

A8WIP5_DANRE A8WIP5_DANRE YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK A5D6R2_DANRE A5D6R2_DANRE YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK Q7SZY1_DANRE Q7SZY1_DANRE YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK Q640G9_XENLA Q640G9_XENLA YNTSTNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK HCFC1_MESAU HCFC1_MESAU YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK HCFC1_MOUSE HCFC1_MOUSE YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK B1AUX1_MOUSE B1AUX1_MOUSE YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK B1AUX2_MOUSE B1AUX2_MOUSE YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK B2KII8_RHIFE B2KII8_RHIFE YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK B7NZP5_RABIT B7NZP5_RABIT YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK B5FW89_OTOGA B5FW89_OTOGA -RVATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK B0KWV2_CALJA B0KWV2_CALJA ------------------------------------------------------------ B1MTW3_CALMO B1MTW3_CALMO YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK A9CB52_PAPAN A9CB52_PAPAN YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK A6NEM2_HUMAN A6NEM2_HUMAN YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK HCFC1_HUMAN HCFC1_HUMAN YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK MATCH CONSENSUS YNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWK

A8WIP5_DANRE A8WIP5_DANRE RLKPKAPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYTLELRPG A5D6R2_DANRE A5D6R2_DANRE KLKPKAPKNGVPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYTLELRPG Q7SZY1_DANRE Q7SZY1_DANRE KLKPKAPKNGVPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYTLELRPG Q640G9_XENLA Q640G9_XENLA RLKAKAPKNGPPPCPRLGHSFSLVGSKCYLFGGLANDSEDPKNNIPRYLNDLYILELRAG HCFC1_MESAU HCFC1_MESAU RLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPG HCFC1_MOUSE HCFC1_MOUSE RLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPG B1AUX1_MOUSE B1AUX1_MOUSE RLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPG B1AUX2_MOUSE B1AUX2_MOUSE RLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPG B2KII8_RHIFE B2KII8_RHIFE RLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPG B7NZP5_RABIT B7NZP5_RABIT RLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPG B5FW89_OTOGA B5FW89_OTOGA RLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPG B0KWV2_CALJA B0KWV2_CALJA ------------------------------------------------------------ B1MTW3_CALMO B1MTW3_CALMO RLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPG A9CB52_PAPAN A9CB52_PAPAN RLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPG A6NEM2_HUMAN A6NEM2_HUMAN RLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPG HCFC1_HUMAN HCFC1_HUMAN RLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPG MATCH CONSENSUS RLK?K?PKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLY?LELRPG

A8WIP5_DANRE A8WIP5_DANRE SNVAGWDIPITYGVLPPPRESHTAVVYTEKTSKKSRLIIYGGMSGCRLGDLWTLDIDTLT A5D6R2_DANRE A5D6R2_DANRE SSVAGWDVPVTYGVLPPPRESHTAVIYTEKVTKKSRLVIYGGMSGCRLGDLWTLDIDTLT Q7SZY1_DANRE Q7SZY1_DANRE SSVAGWDVPVTYGVLPPPRESHTAVIYTEKVTKKSRLVIYGGMSGCRLGDLWTLDIDTLT Q640G9_XENLA Q640G9_XENLA SGVVAWDVPITYGILPPPRESHTAVVYTDKDNKKSRLVIYGGMSGCRLGDLWILDIDTLT HCFC1_MESAU HCFC1_MESAU SGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIETLT HCFC1_MOUSE HCFC1_MOUSE SGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIETLT B1AUX1_MOUSE B1AUX1_MOUSE SGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIETLT B1AUX2_MOUSE B1AUX2_MOUSE SGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIETLT B2KII8_RHIFE B2KII8_RHIFE SGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIETLT B7NZP5_RABIT B7NZP5_RABIT SGVVAWDIPITYGVLPPPRESHTAVVYTERDNKKSKLVIYGGMSGCRLGDLWTLDIETLT B5FW89_OTOGA B5FW89_OTOGA SGVVAWDIPITYGVLPPPRESHTAVVYTERDNKKSKLVIYGGMSGCRLGDLWTLDIETLT B0KWV2_CALJA B0KWV2_CALJA ------------------------------------------------------------ B1MTW3_CALMO B1MTW3_CALMO SGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIDTLT A9CB52_PAPAN A9CB52_PAPAN SGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIDTLT A6NEM2_HUMAN A6NEM2_HUMAN SGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIDTLT HCFC1_HUMAN HCFC1_HUMAN SGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIDTLT MATCH CONSENSUS S?V??WD?PITYGVLPPPRESHTAVVYTEK??KKS?LVIYGGMSGCRLGDLWTLDI?TLT

A8WIP5_DANRE A8WIP5_DANRE WNKPAISGAAPLPRSLHSATTITNKMFVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL A5D6R2_DANRE A5D6R2_DANRE WNKPAISGAAPLPRSLHSATTITNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL Q7SZY1_DANRE Q7SZY1_DANRE WNKPAISGAAPLPRSLHSATTITNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL Q640G9_XENLA Q640G9_XENLA WSKPSLNGVAPLPRSLHSATTILNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL HCFC1_MESAU HCFC1_MESAU WNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL HCFC1_MOUSE HCFC1_MOUSE WNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL B1AUX1_MOUSE B1AUX1_MOUSE WNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL B1AUX2_MOUSE B1AUX2_MOUSE WNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL B2KII8_RHIFE B2KII8_RHIFE WNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL B7NZP5_RABIT B7NZP5_RABIT WNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL B5FW89_OTOGA B5FW89_OTOGA WNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL B0KWV2_CALJA B0KWV2_CALJA -------------------------MYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL B1MTW3_CALMO B1MTW3_CALMO WNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL A9CB52_PAPAN A9CB52_PAPAN WNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL A6NEM2_HUMAN A6NEM2_HUMAN WNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL HCFC1_HUMAN HCFC1_HUMAN WNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL MATCH *:********************************* CONSENSUS WNKP??SG?APLPRSLHSATTI?NKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNL

A8WIP5_DANRE A8WIP5_DANRE DSMSWETILMDTLEDNIPRARAGHCSVAINNRLYVWSGRDGYRKAWNNQVCCKDLWYLET A5D6R2_DANRE A5D6R2_DANRE DTLAWETVLMDTLEDNIPRARAGHCAVAINNRLYIWSGRDGYRKAWNNQVCCKDLWYLET Q7SZY1_DANRE Q7SZY1_DANRE DTLAWETVLMDTLEDNIPRARAGHCAVAINNRLYIWSGRDGYRKAWNNQVCCKDLWYLET Q640G9_XENLA Q640G9_XENLA ESMSWEHIVIDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLET HCFC1_MESAU HCFC1_MESAU DTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLET HCFC1_MOUSE HCFC1_MOUSE DTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLET B1AUX1_MOUSE B1AUX1_MOUSE DTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLET B1AUX2_MOUSE B1AUX2_MOUSE DTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLET B2KII8_RHIFE B2KII8_RHIFE DTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLET B7NZP5_RABIT B7NZP5_RABIT -------------------------------------GMASSGSEWP-----------AG B5FW89_OTOGA B5FW89_OTOGA DTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLET B0KWV2_CALJA B0KWV2_CALJA DTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLET B1MTW3_CALMO B1MTW3_CALMO DTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLET A9CB52_PAPAN A9CB52_PAPAN DTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLET A6NEM2_HUMAN A6NEM2_HUMAN DTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLET HCFC1_HUMAN HCFC1_HUMAN DTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLET MATCH * . . * CONSENSUS DTMAWETILMDTLEDNIPRARAGHCAVAIN?RLYIWSGRDGYRKAWNNQVCCKDLWYLET

A8WIP5_DANRE A8WIP5_DANRE DRPQPPSRVQLVRANTNSLEVSWGAVPTADTYLLQLQKYDIPA-ATAATSPTVNPMPSVP A5D6R2_DANRE A5D6R2_DANRE ERPNPPSRVQLVRANTNSLEVSWGAVSTADTYLLQLQKYDIPA-ATAATSPALNAAPSLP Q7SZY1_DANRE Q7SZY1_DANRE ERPNPPSRVQLVRANTNSLEVSWGAVSTADTYLLQLQKYDIPA-ATAATSPALNAAPSLP Q640G9_XENLA Q640G9_XENLA EKPPAPARVQLVRANTNSLEVSWGAVPTADSYLLQLQKYDIPA-AAAAMSPA-NPVPSVP HCFC1_MESAU HCFC1_MESAU EKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVP HCFC1_MOUSE HCFC1_MOUSE EKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVP B1AUX1_MOUSE B1AUX1_MOUSE EKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVP B1AUX2_MOUSE B1AUX2_MOUSE EKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVP B2KII8_RHIFE B2KII8_RHIFE EKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVP B7NZP5_RABIT B7NZP5_RABIT EKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVP B5FW89_OTOGA B5FW89_OTOGA EKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVP B0KWV2_CALJA B0KWV2_CALJA EKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVP B1MTW3_CALMO B1MTW3_CALMO EKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVP A9CB52_PAPAN A9CB52_PAPAN EKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVP A6NEM2_HUMAN A6NEM2_HUMAN EKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVP HCFC1_HUMAN HCFC1_HUMAN EKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVP MATCH ::* .*:*******************.***:************ *::* **: *. **:* CONSENSUS EKPPPPARVQLVRANTNSLEVSWGAV?TADSYLLQLQKYDIPA?AA?ATSPT?NPVPSVP

A8WIP5_DANRE A8WIP5_DANRE VNSPKSPVPAAAAPAAQSMPLSGVTLVPQVPS--PTTAM-------PTSPLAAS-PRG-- A5D6R2_DANRE A5D6R2_DANRE GNSPKSPAPAAAAPSAQSLPHSGITSVPQAAS--PTAS---VLPGTPASPLAASMARG-- Q7SZY1_DANRE Q7SZY1_DANRE GNSPKSPAPAAAAPSAQSLPHSGITSVPQAAS--PTAS---VLPGTPASPLAASMARG-- Q640G9_XENLA Q640G9_XENLA VNPPKSPAPASAAPTVQQVAHTGITLLPQAASLPPTTATIQVLPTMPGSPIAVSAALRTQ HCFC1_MESAU HCFC1_MESAU ANPPKSPAPAAAAPAVQPLTQVGITLVPQAAAAPPSTTTIQVLPTVPGSSISVPTAARAQ HCFC1_MOUSE HCFC1_MOUSE ANPPKSPAPAAAAPAVQPLTQVGITLVPQAATAPPSTTTIQVLPTVPGSSISVPTAARTQ B1AUX1_MOUSE B1AUX1_MOUSE ANPPKSPAPAAAAPAVQPLTQVGITLVPQAATAPPSTTTIQVLPTVPGSSISVPTAARTQ B1AUX2_MOUSE B1AUX2_MOUSE ANPPKSPAPAAAAPAVQPLTQVGITLVPQAATAPPSTTTIQVLPTVPGSSISVPTAARTQ B2KII8_RHIFE B2KII8_RHIFE TNPPKSPAPAAAAPAVQPLTQVGITLLPQAAAAPPTTTTIQVLPPVPGSSISVPAAARTQ B7NZP5_RABIT B7NZP5_RABIT ANPPKSPAPAAAAPAVQPLTQVGITLLPQAAAAPPTTTTIQVLPTVPGSSISVPTAARTQ B5FW89_OTOGA B5FW89_OTOGA ANPPKSPAPAAAAPAVQPLTQVGITLLPQAAAAPPTTTTIQVLPTVPGSSISVPTAARTQ B0KWV2_CALJA B0KWV2_CALJA ANPPKSPAPAAAAPAVQPLTQVGITLLPQAAPAPPTTTTIQVLPTVPGSSISVPTAARTQ B1MTW3_CALMO B1MTW3_CALMO ANPPKSPAPAAAAPAVQPLTQVGITLLPQAAPAPPTTTTIQVLPTVPGSSISVPTAARTQ A9CB52_PAPAN A9CB52_PAPAN ANPPKSPAPAAAAPAVQPLTQVGITLLPQAAPAPPTTTTIQVLPTVPGSSISVPTAARTQ A6NEM2_HUMAN A6NEM2_HUMAN ANPPKSPAPAAAAPAVQPLTQVGITLLPQAAPAPPTTTTIQVLPTVPGSSISVPTAARTQ HCFC1_HUMAN HCFC1_HUMAN ANPPKSPAPAAAAPAVQPLTQVGITLLPQAAPAPPTTTTIQVLPTVPGSSISVPTAARTQ MATCH *.****.**:***:.* :. *:* :**... *::: * *.::.. . CONSENSUS ?NPPKSPAPAAAAPAVQ?L???GITL?PQAA??PP?T?TIQVLP??PGS?I?V??A?R?Q

A8WIP5_DANRE A8WIP5_DANRE --PAILKVAAPHSTPGTSVVTVRQATPGAKSPVTVTSLPAGVRMVVPAQSTQGTPIGSSP A5D6R2_DANRE A5D6R2_DANRE --PAILKVAAPQSGTGASIVTVRQASQVGKSPVTVASLPAGVRMVVPSQTAQGTPIGSSP Q7SZY1_DANRE Q7SZY1_DANRE --PAILKVAAPQSGTGASIVTVRQASQVGKSPVTVASLPAGVRMVVPSQTAQGT-IGSSP Q640G9_XENLA Q640G9_XENLA AVPAVLKVGGQQSTLSTPLVTVRPANQISKAPVTVTSLPPGVRMVVPAQSTQGAPIGSSQ HCFC1_MESAU HCFC1_MESAU GVPAVLKVTGPQATTGTPLVTMRPAGQAGKAPVTVTSLPASVRMVVPTQSAQGTVIGSNP HCFC1_MOUSE HCFC1_MOUSE GRPAVLKVTGPQATTGTPLVTMRPASQAGKAPVTVTSLPASVRMVVPTQSAQGTVIGSNP B1AUX1_MOUSE B1AUX1_MOUSE GVPAVLKVTGPQATTGTPLVTMRPASQAGKAPVTVTSLPASVRMVVPTQSAQGTVIGSNP B1AUX2_MOUSE B1AUX2_MOUSE GVPAVLKVTGPQATTGTPLVTMRPASQAGKAPVTVTSLPASVRMVVPTQSAQGTVIGSNP B2KII8_RHIFE B2KII8_RHIFE GVPAVLKVTGPQATTGTPLVTMRPASQAGKAPVTMTSLPAGVRMVVPTQSAQGTVIGSNP B7NZP5_RABIT B7NZP5_RABIT GVPAVLKVTGPQATTGTPLVTMRPASQPGKAPVTVTSLPAGVRMVVPTQSAQGTVIGSNP B5FW89_OTOGA B5FW89_OTOGA GVPAVLKVTGPQATTGTPLVTMRPASQAGKAPVTVTSLPAGVRMVVPTQSAQGTVIGSSP B0KWV2_CALJA B0KWV2_CALJA GVPAVLKVTGPQATTGTPLVTMRPASQAGKAPVTVTSLPAGVRMVVPTQSAQGTVIGSSP B1MTW3_CALMO B1MTW3_CALMO GVPAVLKVTGPQATTGTPLVTMRPASQAGKAPVTVTSLPAGVRMVVPTQSAQGTVIGSSP A9CB52_PAPAN A9CB52_PAPAN GVPAVLKVTGPQATTGTPLVTMRPTSQAGKAPVTVTSLPAGVRMVVPTQSAQGTVIGSSP A6NEM2_HUMAN A6NEM2_HUMAN GVPAVLKVTGPQATTGTPLVTMRPASQAGKAPVTVTSLPAGVRMVVPTQSAQGTVIGSSP HCFC1_HUMAN HCFC1_HUMAN GVPAVLKVTGPQATTGTPLVTMRPASQAGKAPVTVTSLPAGVRMVVPTQSAQGTVIGSSP MATCH **:*** . :: .:.:**:* : .*:***::***..******:*::**: ***. CONSENSUS ??PAVLKV?GPQ?TTGTPLVT?RPASQ?GKAPVTVTSLPA?VRMVVP?QSAQGT?IGS?P

A8WIP5_DANRE A8WIP5_DANRE QMSGMAALAAAAAATQKIPPSSATTVLNVPAGATLVKTVAVTPGSTTLPATVKVA-SPVM A5D6R2_DANRE A5D6R2_DANRE QMSGMAALAAAAAATQKIPPSPGATVLNMPAGATIVKTVAVTPGASTLPTTVKVA-SPLM Q7SZY1_DANRE Q7SZY1_DANRE QMSGMAALAAAAAATQKIPPSPGATVLNMPAGATIVKTVAVTPGASTLPTTVKVA-SPLM Q640G9_XENLA Q640G9_XENLA PMSGMAALAAAAAATQKIPPSSAPTMLGVPAGATMVKSVAVPSGVTSLPTTVKVASSPIM HCFC1_MESAU HCFC1_MESAU QMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTVAVTPGTTTLPATVKVASSPVM HCFC1_MOUSE HCFC1_MOUSE QMSGMAALAAAAAATQKIPPSSAPTAWSVPAGTTIVKTVAVTPGTTTLPATVKVASSPVM B1AUX1_MOUSE B1AUX1_MOUSE QMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTVAVTPGTTTLPATVKVASSPVM B1AUX2_MOUSE B1AUX2_MOUSE QMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTVAVTPGTTTLPATVKVASSPVM B2KII8_RHIFE B2KII8_RHIFE QMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTVAVTPGTTTLPATVKVASSPVM B7NZP5_RABIT B7NZP5_RABIT QMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTVAVTPGTTTLPATVKVASSPVM B5FW89_OTOGA B5FW89_OTOGA QMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTVAVTPGTTTLPATVKVASSPVM B0KWV2_CALJA B0KWV2_CALJA QMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTMAVTPGTTTLPATVKVASSPVM B1MTW3_CALMO B1MTW3_CALMO QMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTMAVTPGTTTLPATVKVASSPVM A9CB52_PAPAN A9CB52_PAPAN QMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTMAVTPGTTTLPATVKVASSPVM A6NEM2_HUMAN A6NEM2_HUMAN QMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTMAVTPGTTTLPATVKVASSPVM HCFC1_HUMAN HCFC1_HUMAN QMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTMAVTPGTTTLPATVKVASSPVM MATCH ********************...* .:***:*:**::**..* ::**:***** **:* CONSENSUS QMSGMAALAAAAAATQKIPPSSAPTVL?VPAG?TIVKT?AVTPG?TTLPATVKVASSPVM

A8WIP5_DANRE A8WIP5_DANRE VTNPATRMLKTAAAQVGTSAISTPNTPTRPIITVHKSGTVTVAQQAQVVTTMVGGVTKTI A5D6R2_DANRE A5D6R2_DANRE VSNPATRMLKTAAAQVATPTVSSPTTGARPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI Q7SZY1_DANRE Q7SZY1_DANRE VSNPATRMLKTAAAQVATPTVSSPTTGARPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI Q640G9_XENLA Q640G9_XENLA VSNPATRMLKTAAAQVGTSVPGS-NTQNRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI HCFC1_MESAU HCFC1_MESAU VSNPATRMLKTAAAQVGTSVSSAANTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI HCFC1_MOUSE HCFC1_MOUSE VSNPATRMLKTAAAQVGTSVSSAANTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI B1AUX1_MOUSE B1AUX1_MOUSE VSNPATRMLKTAAAQVGTSVSSAANTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI B1AUX2_MOUSE B1AUX2_MOUSE VSNPATRMLKTAAAQVGTSVSSAANTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI B2KII8_RHIFE B2KII8_RHIFE VSNPATRMLKTAAAQVGTSVSSAANTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI B7NZP5_RABIT B7NZP5_RABIT VSNPATRMLKTAAAQVGTSVSSAANTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI B5FW89_OTOGA B5FW89_OTOGA VSNPATRMLKTAAAQVGTSVSSATNTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI B0KWV2_CALJA B0KWV2_CALJA VSNPATRMLKTAAAQVGTSVSSATNTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI B1MTW3_CALMO B1MTW3_CALMO VSNPATRMLKTAAAQVGTSVSSATNTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI A9CB52_PAPAN A9CB52_PAPAN VSNPATRMLKTAAAQVGTSVSSATNTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI A6NEM2_HUMAN A6NEM2_HUMAN VSNPATRMLKTAAAQVGTSVSSATNTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI HCFC1_HUMAN HCFC1_HUMAN VSNPATRMLKTAAAQVGTSVSSATNTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI MATCH *:**************.*.. .: .* ***********************:******** CONSENSUS VSNPATRMLKTAAAQVGTSV?S??NT?TRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTI

A8WIP5_DANRE A8WIP5_DANRE TLVKSPITMGGSGALYSQLSSLGKVMSVVQTKPVQTSAVTGQAGS-SPVTLIQTKTPLPA A5D6R2_DANRE A5D6R2_DANRE TLVKSPLSMGGN--L---ISNLGKVVSVVQNKPVQSATVTGQASN-PLTQIIQTKGPLPP Q7SZY1_DANRE Q7SZY1_DANRE TLVKSPLSMGGN--L---ISNLGKVVSVVQNKPVQSATVTGQASN-PLTQIIQTKGPLPP Q640G9_XENLA Q640G9_XENLA TLVKSPISVPGGSAL---ISNLGKMMSVVQTKPVQTSAITGQASTGPLTQIIQTKGPLPA HCFC1_MESAU HCFC1_MESAU TLVKSPISVPGGSAL---ISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPA HCFC1_MOUSE HCFC1_MOUSE TLVKSPISVPGGSAL---ISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPA B1AUX1_MOUSE B1AUX1_MOUSE TLVKSPISVPGGSAL---ISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPA B1AUX2_MOUSE B1AUX2_MOUSE TLVKSPISVPGGSAL---ISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPA B2KII8_RHIFE B2KII8_RHIFE TLVKSPISVPGGSAL---ISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPA B7NZP5_RABIT B7NZP5_RABIT TLVKSPISVPGGSAL---ISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPA B5FW89_OTOGA B5FW89_OTOGA TLVKSPISVPGGSAL---ISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPA B0KWV2_CALJA B0KWV2_CALJA TLVKSPISVPGGSAL---ISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPA B1MTW3_CALMO B1MTW3_CALMO TLVKSPISVPGGSAL---ISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPA A9CB52_PAPAN A9CB52_PAPAN TLVKSPISVPGGSAL---ISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPA A6NEM2_HUMAN A6NEM2_HUMAN TLVKSPISVPGGSAL---ISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPA HCFC1_HUMAN HCFC1_HUMAN TLVKSPISVPGGSAL---ISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPA MATCH ******::: *. * :*.***::****.****::::****.. . . :**** ***. CONSENSUS TLVKSPISVPGGSAL???ISNLGKVMSVVQTKPVQTSAVTGQASTGP?TQIIQTKGPLPA

A8WIP5_DANRE A8WIP5_DANRE GTILKLVTSADGKPTTIITTSQAGGTGTKPTILGISSVSPTTTNKPG-TTIIKTIPMSAL A5D6R2_DANRE A5D6R2_DANRE GTILKLVTSADGKPTTIITTSQAGGTGNKPTILGISGMSPTSTSKPGTTTIIKTIPMSAV Q7SZY1_DANRE Q7SZY1_DANRE GTILKLVTSADGKPTTIITTSQAGGTGNKPTILGISGMSPTSTSKPGTTTIIKTIPMSAV Q640G9_XENLA Q640G9_XENLA GTILKLVTSADGKPATIITTTQAGGTGTKPTILGISSVSP-NTTKPGTTTIIKTIPMSAI HCFC1_MESAU HCFC1_MESAU GTILKLVTSADGKPTTIITTTQASGAGSKPTILGISSVSP-STTKPGTTTIIKTIPMSAI HCFC1_MOUSE HCFC1_MOUSE GTILKLVTSADGKPTTIITTTQASGAGTKPTILGISSVSP-STTKPGTTTIIKTIPMSAI B1AUX1_MOUSE B1AUX1_MOUSE GTILKLVTSADGKPTTIITTTQASGAGTKPTILGISSVSP-STTKPGTTTIIKTIPMSAI B1AUX2_MOUSE B1AUX2_MOUSE GTILKLVTSADGKPTTIITTTQASGAGTKPTILGISSVSP-STTKPGTTTIIKTIPMSAI B2KII8_RHIFE B2KII8_RHIFE GTILKLVTSADGKPTTIITTTQASGAGTKPTILGISSVSP-STTKPGTTTIIKTIPMSAI B7NZP5_RABIT B7NZP5_RABIT GTILKLVTSADGKPTTIITTTQASGAGTKPTILGISSVSP-STTKPGTTTIIKTIPMSAI B5FW89_OTOGA B5FW89_OTOGA GTILKLVTSADGKPTTIITTTQASGAGAKPTILGISSVSP-STTKPGTTTIIKTIPMSAI B0KWV2_CALJA B0KWV2_CALJA GTILKLVTSADGKPTTIITTTQASGAGTKPTILGISSVSP-STTKPGTTTIIKTIPMSAI B1MTW3_CALMO B1MTW3_CALMO GTILKLVTSADGKPTTIITTTQASGAGTKPTILGISSVSP-STTKPGTTTIIKTIPMSAI A9CB52_PAPAN A9CB52_PAPAN GTILKLVTSADGKPTTIITTTQASGAGTKPTILGISSVSP-STTKPGTTTIIKTIPMSAI A6NEM2_HUMAN A6NEM2_HUMAN GTILKLVTSADGKPTTIITTTQASGAGTKPTILGISSVSP-STTKPGTTTIIKTIPMSAI HCFC1_HUMAN HCFC1_HUMAN GTILKLVTSADGKPTTIITTTQASGAGTKPTILGISSVSP-STTKPGTTTIIKTIPMSAI MATCH **************:*****:**.*:* ********.:** .*.*** ***********: CONSENSUS GTILKLVTSADGKPTTIITTTQA?G?G?KPTILGISSVSP?STTKPGTTTIIKTIPMSAI

A8WIP5_DANRE A8WIP5_DANRE ---QGATGVTSSAGIKSPITIITTKVVTPGTGTPGKIITAVPKL-TGAGQQGVTQVVLKG A5D6R2_DANRE A5D6R2_DANRE --QQGAAGVTSTTGVKSPITIITTKVMTS--GTPGKIITAMPKIGTAAGQQGLTQVVLKG Q7SZY1_DANRE Q7SZY1_DANRE --QQGAAGVTSTTGVKSPITIITTKVMTS--GTPGKIITAMPKIGTAAGQQGLTQVVLKG Q640G9_XENLA Q640G9_XENLA ITQAGATGVTSTAGIKSPITILTTKMGTSGTGTPAKIITAVPKHTATLGQQGLTQVVLKG HCFC1_MESAU HCFC1_MESAU ITQAGATGVTSTPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKG HCFC1_MOUSE HCFC1_MOUSE ITQAGATGVTSSPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKG B1AUX1_MOUSE B1AUX1_MOUSE ITQAGATGVTSSPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKG B1AUX2_MOUSE B1AUX2_MOUSE ITQAGATGVTSSPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKG B2KII8_RHIFE B2KII8_RHIFE ITQAGATGVTSTPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKG B7NZP5_RABIT B7NZP5_RABIT ITQAGATGVTSSPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKG B5FW89_OTOGA B5FW89_OTOGA ITQAGAAGVTSSPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKG B0KWV2_CALJA B0KWV2_CALJA ITQAGATGVTSSPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKG B1MTW3_CALMO B1MTW3_CALMO ITQAGATGVTSSPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKG A9CB52_PAPAN A9CB52_PAPAN ITQAGATGVTSSPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKG A6NEM2_HUMAN A6NEM2_HUMAN ITQAGATGVTSSPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKG HCFC1_HUMAN HCFC1_HUMAN ITQAGATGVTSSPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKG MATCH **:****:.*:******:***: *. *:*.*****:** : ****:******* CONSENSUS ITQAGATGVTS??GIKSPITIITTKVMTSGTG?PAKIITAVPKI?TG?GQQGVTQVVLKG

A8WIP5_DANRE A8WIP5_DANRE APGQPGTILRTVPMGGVRLVSPGTVSADKPTVTTLVVKGTTGVTTLGTVTGTVSTSVAGA A5D6R2_DANRE A5D6R2_DANRE APGQPGTILRTVPMGGVRLVSP--VSGVKPTVTTLVVKGTTGVTTLGTVTGTVSSSLAGG Q7SZY1_DANRE Q7SZY1_DANRE APGQPGTILRTVPMGGVRLVSP--VSGVKPTVTTLVVKGTTGVTTLGTVTGTVSSSLAGG Q640G9_XENLA Q640G9_XENLA APGQPGTILRTVPMSGMRLVTP--VSAVKPTVTTLVVKGTTGVTTLGTVSGTVSTSLAGG HCFC1_MESAU HCFC1_MESAU APGQPGAILRTVPMSGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGA HCFC1_MOUSE HCFC1_MOUSE APGQPGTILRTVPMGGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGA B1AUX1_MOUSE B1AUX1_MOUSE APGQPGTILRTVPMGGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGA B1AUX2_MOUSE B1AUX2_MOUSE APGQPGTILRTVPMGGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGA B2KII8_RHIFE B2KII8_RHIFE APGQPGTILRTVPMGGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGA B7NZP5_RABIT B7NZP5_RABIT APGQPGTILRTVPMGGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGA B5FW89_OTOGA B5FW89_OTOGA APGQPGTILRTVPMGGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGA B0KWV2_CALJA B0KWV2_CALJA APGQPGTILRTVPMGGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGA B1MTW3_CALMO B1MTW3_CALMO APGQPGTILRTVPMGGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGA A9CB52_PAPAN A9CB52_PAPAN APGQPGTILRTVPMGGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGA A6NEM2_HUMAN A6NEM2_HUMAN APGQPGTILRTVPMGGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGA HCFC1_HUMAN HCFC1_HUMAN APGQPGTILRTVPMGGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGA MATCH ******:*******.*:***:* **. **:******************:****:*:**. CONSENSUS APGQPGTILRTVPMGGVRLVTP?TVSAVKP?VTTLVVKGTTGVTTLGTVTGTVSTSLAGA

A8WIP5_DANRE A8WIP5_DANRE NV--ANASLATPVTTLASIATLSSQVINPTAITVSAAQTNLATA--------TIQSASQP A5D6R2_DANRE A5D6R2_DANRE SLASANATLATPITTLGTIATLASQVINATNVT--AAQSNLT----------TVTSTMQP Q7SZY1_DANRE Q7SZY1_DANRE SLASANATLATPITTLGTIATLASQVINATNVT--AAQSNLT----------TVTSTMQP Q640G9_XENLA Q640G9_XENLA GVHN-SASLATPINTLGTIATLSSQVINPGAITMSAAQTSLTAASGLSTPTITMQPLSQP HCFC1_MESAU HCFC1_MESAU GAHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQP HCFC1_MOUSE HCFC1_MOUSE GAHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQP B1AUX1_MOUSE B1AUX1_MOUSE GAHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQP B1AUX2_MOUSE B1AUX2_MOUSE GAHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQP B2KII8_RHIFE B2KII8_RHIFE GGHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAASGLTTPTITMQPVSQP B7NZP5_RABIT B7NZP5_RABIT GGHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLSTPTITMQPVSQP B5FW89_OTOGA B5FW89_OTOGA GGHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLSTPTITMQPVSQP B0KWV2_CALJA B0KWV2_CALJA GGHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQP B1MTW3_CALMO B1MTW3_CALMO GGHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQP A9CB52_PAPAN A9CB52_PAPAN GGHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQP A6NEM2_HUMAN A6NEM2_HUMAN GGHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQP HCFC1_HUMAN HCFC1_HUMAN GGHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQP MATCH . .*:****:.**.:****:*****. :* ***:.*: *: . ** CONSENSUS G?HS?SASLATPITTLGTIATLSSQVINPTAITVSAAQT?LTAA?GL?TPTITMQP?SQP

A8WIP5_DANRE A8WIP5_DANRE TQVTLITTPSGAEAQPGQDLPVSFLASPTSEQPSTT----GADAGD-SAGDGATTVTLVC A5D6R2_DANRE A5D6R2_DANRE TQVTLITTPSGVEAQPGQDLPVSFLASPTSEQPTST----ESGTGE-ASG----SVTLVC Q7SZY1_DANRE Q7SZY1_DANRE TQVTLITTPSGVEAQPGQDLPVSFLASPTSEQPTST----ESGTGE-ASG----SVTLVC Q640G9_XENLA Q640G9_XENLA TQVTLITTPSGVEAQPVHDLPVSILASPTSDQPTATVTIADSGQGD-QPG----TVTLVC HCFC1_MESAU HCFC1_MESAU TQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPG----TVTLVC HCFC1_MOUSE HCFC1_MOUSE TQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPG----TVTLVC B1AUX1_MOUSE B1AUX1_MOUSE TQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPG----TVTLVC B1AUX2_MOUSE B1AUX2_MOUSE TQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPG----TVTLVC B2KII8_RHIFE B2KII8_RHIFE TQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPG----TVTLVC B7NZP5_RABIT B7NZP5_RABIT TQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPG----TVTLVC B5FW89_OTOGA B5FW89_OTOGA TQVTLITAPSGVEAQPVHDLPVSILASPTTEQPSATVTIADSGQGDVQPG----TVTLVC B0KWV2_CALJA B0KWV2_CALJA TQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPG----TVTLVC B1MTW3_CALMO B1MTW3_CALMO TQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPG----TVTLVC A9CB52_PAPAN A9CB52_PAPAN TQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPG----TVTLVC A6NEM2_HUMAN A6NEM2_HUMAN TQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPG----TVTLVC HCFC1_HUMAN HCFC1_HUMAN TQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPG----TVTLVC MATCH *******:***.**** :*****:*****::**::* :. *: .* :***** CONSENSUS TQVTLIT?PSGVEAQPVHDLPVSILASPT?EQPTATVTIADSGQGD?QPG????TVTLVC

A8WIP5_DANRE A8WIP5_DANRE SNPPCETHETGTTNTATTA-SAKIG---------------------------------TE A5D6R2_DANRE A5D6R2_DANRE SNPPCETHETGTTNTATTA-TSNMGAGPA---------------------------GTVQ Q7SZY1_DANRE Q7SZY1_DANRE SNPPCETHETGTTNTATTA-TSNMGAGPA---------------------------GTVQ Q640G9_XENLA Q640G9_XENLA SNPPCETHETGTTNTATTSLVNLSSIVQQPGGTLQFVCEGQE-PGTYVATSLAQANGSVV HCFC1_MESAU HCFC1_MESAU SNPPCETHETGTTNTATTTVVANLGGHPQP-TQVQFVCDRQEAAASLVTSAVGQQNGNVV HCFC1_MOUSE HCFC1_MOUSE SNPPCETHETGTTNTATTTVVANLGGHPQP-TQVQFVCDRQETAASLVTSAVGQQNGNVV B1AUX1_MOUSE B1AUX1_MOUSE SNPPCETHETGTTNTATTTVVANLGGHPQP-TQVQFVCDRQETAASLVTSAVGQQNGNVV B1AUX2_MOUSE B1AUX2_MOUSE SNPPCETHETGTTNTATTTVVANLGGHPQP-TQVQFVCDRQETAASLVTSAVGQQNGNVV B2KII8_RHIFE B2KII8_RHIFE SNPPCETHETGTTNTATTTVVANLGGHPQP-TQVQFVCDRQDAAASLVTSTVGQQNGSVV B7NZP5_RABIT B7NZP5_RABIT SNPPCETHETGTTNTATTTVVANLGGHPQP-TQVQFVCDRQEAAATLVTSAVAQQNGSVV B5FW89_OTOGA B5FW89_OTOGA SNPPCETHETGTTNTATTTVVANLGGHPQP-TQVQFVCDRQEAAASLVTSTMGQQNGSVV B0KWV2_CALJA B0KWV2_CALJA SNPPCETHETGTTNTATTTVVANLGGHPQP-TQVQFVCDRQDAAASLVTSTVGQQNGSVV B1MTW3_CALMO B1MTW3_CALMO SNPPCETHETGTTNTATTTVVANLGGHPQP-TQVQFVCDRQEATASLVTSTVGQQNGSVV A9CB52_PAPAN A9CB52_PAPAN SNPPCETHETGTTNTATTTVVANLGGHPQP-TQVQFVCDRQEAAASLVTSTVGQQNGSVV A6NEM2_HUMAN A6NEM2_HUMAN SNPPCETHETGTTNTATTTVVANLGGHPQP-TQVQFVCDRQEAAASLVTSTVGQQNGSVV HCFC1_HUMAN HCFC1_HUMAN SNPPCETHETGTTNTATTTVVANLGGHPQP-TQVQFVCDRQEAAASLVTSTVGQQNGSVV MATCH ******************: . . CONSENSUS SNPPCETHETGTTNTATT??VAN?G??PQP????QFVC??Q??????V?????Q?NG?VV

A8WIP5_DANRE A8WIP5_DANRE QICSNPPCETHVTGTTNTSTTASANMGRAQQ----VCTNPPSETHDTGTTNTATTASCNM A5D6R2_DANRE A5D6R2_DANRE RVCSN----------------------------------PPCETHETGTTNTATTASANM Q7SZY1_DANRE Q7SZY1_DANRE RVCSN----------------------------------PPCETHETGTTNTATTASANM Q640G9_XENLA Q640G9_XENLA RVCSNPPCETHETGTTQTSTTAMASI-GQTGIVTRVCSNPPCETHETGTTQTPTTAMSNI HCFC1_MESAU HCFC1_MESAU RVCSNPPCETHETGTTNTATTATSNMAGQHG-----CSNPPCETHETGTTSTATTAMSSM HCFC1_MOUSE HCFC1_MOUSE RVCSNPPCETHETGTTNTATTATSNMAGQHG-----SSNPPCETHETGTTSTATTAMSSM B1AUX1_MOUSE B1AUX1_MOUSE RVCSNPPCETHETGTTNTATTATSNMAGQHG-----CSNPPCETHETGTTSTATTAMSSM B1AUX2_MOUSE B1AUX2_MOUSE RVCSNPPCETHETGTTNTATTATSNMAGQHG-----CSNPPCETHETGTTSTATTAMSSM B2KII8_RHIFE B2KII8_RHIFE RVCSNPPCETHETGTTNTATTATSNMAGQHG-----CSNPPCETHETGTTNTASTAMSSI B7NZP5_RABIT B7NZP5_RABIT RVCSNPPCETHETGTTNTATTATSNMAGQHG-----CSNPPCETHETGTTSTATTAVSSI B5FW89_OTOGA B5FW89_OTOGA RVCSNPPCETHETGTTNTATTATSNMAGQHS-----CSDPPCETHETGTTNTATTAMSNV B0KWV2_CALJA B0KWV2_CALJA RVCSNPPCETHETGTTNTATTATSNMAGQHG-----CSNPPCETHETGTTNTATTAMSSV B1MTW3_CALMO B1MTW3_CALMO RVCSNPPCETHETGTTNTATTATSNMAGQHG-----CSNPPCETHETGTTNTATTAMSSV A9CB52_PAPAN A9CB52_PAPAN RVCSNPPCETHETGTTTTATTATSNMAGQHG-----CSNPPCETHETGTTNTATTAMSSV A6NEM2_HUMAN A6NEM2_HUMAN RVCSNPPCETHETGTTNTATTATSNMAGQHG-----CSNPPCETHETGTTNTATTAMSSV HCFC1_HUMAN HCFC1_HUMAN RVCSNPPCETHETGTTNTATTATSNMAGQHG-----CSNPPCETHETGTTNTATTAMSSV MATCH ::*** **.***:****.*.:** ..: CONSENSUS RVCSNPPCETHETGTT?T?TTA??NM?GQ???????CSNPPCETHETGTT?TATTA?S??

A8WIP5_DANRE A8WIP5_DANRE GSTEMGTVNSKPGSSSPPASSSSEPSTPVSESGAEAGVMRPENLRTGTTYTSTTARSNMG A5D6R2_DANRE A5D6R2_DANRE GA-----VQRVCS------------------------NPPCETHETGTTSTTTTASSN-- Q7SZY1_DANRE Q7SZY1_DANRE GA-----VQRVCS------------------------NPPCETHETGTTSTTTTASSN-- Q640G9_XENLA Q640G9_XENLA GSGEMGTVTRICS------------------------NPPCETHETGTTQTSTTAMAN-- HCFC1_MESAU HCFC1_MESAU GTGQQRDTRHTSS---NPTVVRITVAPGALERTQGTVKPQCQTQQANMTNTTMTVQATRS HCFC1_MOUSE HCFC1_MOUSE GTGQQRDTRRTTN---TPTVVRITVAPGALERVQGTVKPQCQTQQTNMTTTTMTVQATGA B1AUX1_MOUSE B1AUX1_MOUSE GTGQQRDTRRTTN---TPTVVRITVAPGALERVQGTVKPQCQTQQTNMTTTTMTVQATGA B1AUX2_MOUSE B1AUX2_MOUSE GTGQQRDTRRTTN---TPTVVRITVAPGALERVQGTVKPQCQTQQTNMTTTTMTVQATGA B2KII8_RHIFE B2KII8_RHIFE GASQQRDTRHSCATTTTPAVVRVGVAAGALEGAQNSVKASCQTRQTSATSTTMTVMATGA B7NZP5_RABIT B7NZP5_RABIT GASQQRDARRACA-TSTPAVVRIGVAAGGSEGAQGSVKPQCQTRQTSATSTTMTVMATGV B5FW89_OTOGA B5FW89_OTOGA GTSQQRDTRRVCV-ASNPTVVRISVSTGAVEGAQVS-KPQCQTRQTSATSTTMTVMATGA B0KWV2_CALJA B0KWV2_CALJA GASHQRDARRACV-AGTPAVIRISVAAGALEAAQGS-KPQCQTRQTSATSTTMTVMATGA B1MTW3_CALMO B1MTW3_CALMO GANHQRDARRACV-AGTPAVIRISVATGALEAAQGS-KPQCQTRQTSVTSTTMTVMASGA A9CB52_PAPAN A9CB52_PAPAN GANHQRDARRACA-AGTPAVIRISVATGALEAAQGS-KPQCQTRQTSTTSTTMTVMATGA A6NEM2_HUMAN A6NEM2_HUMAN GANHQRDARRACA-AGTPAVIRISVATGALEAAQGS-KSQCQTRQTSATSTTMTVMATGA HCFC1_HUMAN HCFC1_HUMAN GANHQRDARRACA-AGTPAVIRISVATGALEAAQGS-KSQCQTRQTSATSTTMTVMATGA MATCH *: . :. .:. * *: *. :. CONSENSUS G????????R???????P????????????E?????????C?T??T??T?TT?T??A???

A8WIP5_DANRE A8WIP5_DANRE SDQTGTVQSSNKSQAAISSTMMPVSSSESPGDTD-TSDVSGSVC------SNPPCETRET A5D6R2_DANRE A5D6R2_DANRE ------------------------------------------------------------ Q7SZY1_DANRE Q7SZY1_DANRE ------------------------------------------------------------ Q640G9_XENLA Q640G9_XENLA -------------MDSG------------------QGESSKKIC------SNPPCETHET HCFC1_MESAU HCFC1_MESAU PCPAGPLLRPSVALEAGNHSPAFVQLALPSVRVGLSGPSNKDMP------TGHQLETYHT HCFC1_MOUSE HCFC1_MOUSE PCSAGPLLRPSVALESGSHSPAFVQLALPSVRVGLSGPSSKDMP------TARQPETYHT B1AUX1_MOUSE B1AUX1_MOUSE PCSAGPLLRPSVALESGSHSPAFVQLALPSVRVGLSGPSSKDMP------TGRQPETYHT B1AUX2_MOUSE B1AUX2_MOUSE PCSAGPLLRPSVALESGSHSPAFVQLALPSVRVGLSGPSSKDMP------TGRQPETYHT B2KII8_RHIFE B2KII8_RHIFE PCSASPLLGPGLALEAGGHGTAFVQLAPASGQVRPSGPSGKDSPVAGLVSTGHQLEAHHS B7NZP5_RABIT B7NZP5_RABIT PYSAGPLLGPSMALEAGGHGTTFVQLAPLSSRVGPGGAGSKNVP------LGRQLETLHI B5FW89_OTOGA B5FW89_OTOGA PRSAGSFL--------GAHSPAFVQLASL---------SSKDMP------VGLQLETPHA B0KWV2_CALJA B0KWV2_CALJA PCSAGPLLGPSMAREPGGRGTAFVQLAPLSSKVRLSSPGSKDLP------T-----GRHS B1MTW3_CALMO B1MTW3_CALMO PCLAGPLLGPSVAREPGGRGTAFVQLAPLSSKVRLSSPGSKDLP------T-----GRHS A9CB52_PAPAN A9CB52_PAPAN PCSAGPLLGPSMAREPGGRGPAFVQLAPLSSKVRLSSPGSKDLP------A-----GRHS A6NEM2_HUMAN A6NEM2_HUMAN PCSAGPLLGPSMAREPGGRSPAFVQLAPLSSKVRLSSPSIKDLP------A-----GRHS HCFC1_HUMAN HCFC1_HUMAN PCSAGPLLGPSMAREPGGRSPAFVQLAPLSSKVRLSSPSIKDLP------A-----GRHS MATCH CONSENSUS ????????????????G??????V????????????????K???????????????????

A8WIP5_DANRE A8WIP5_DANRE GTTSTPTQSSADMESGQSGSVQRVCSNPPCETHETGTTNTSTQASSSMA-AGQSGTAQRV A5D6R2_DANRE A5D6R2_DANRE -----------------MGTA-------------------------------PAGTVQRV Q7SZY1_DANRE Q7SZY1_DANRE -----------------MGTA-------------------------------PAGTVQRV Q640G9_XENLA Q640G9_XENLA GTTPTATTARSNIGKEQTDNTQRL-SKPPCETMQTVSTHTVMTVP-------DSFTSGLT HCFC1_MESAU HCFC1_MESAU YTTNTPTTALSIMGAGELGTARLI-PTSTYESLQASSPSSTMTMTALEALLCPSATVTQV HCFC1_MOUSE HCFC1_MOUSE YTTNTPTTTRSIMVAGELGAARVV-PTSTYESLQASSPSSTMTMTALEALLCPSATVTQV B1AUX1_MOUSE B1AUX1_MOUSE YTTNTPTTTRSIMVAGELGAARVV-PTSTYESLQASSPSSTMTMTALEALLCPSATVTQV B1AUX2_MOUSE B1AUX2_MOUSE YTTNTPTTTRSIMVAGELGAARVV-PTSTYESLQASSPSSTMTMTALEALLCPSATVTQV B2KII8_RHIFE B2KII8_RHIFE HNISTPSTACSSMGAGEPGEMRGL-PTHAYES----SASAPVTVTALEALLGSSTTVTQV B7NZP5_RABIT B7NZP5_RABIT HTSNSPAVVRGP-------------LTPVYDSLQSSSPSTTVTVTALEALLCPSATVTQV B5FW89_OTOGA B5FW89_OTOGA HTASTLTTAHPMLSVGELGAAQGA-PAPAYES---SPPSTTVTVTALEALLCPSGTVTQV B0KWV2_CALJA B0KWV2_CALJA HAANTATMARS-----SVGAGEPR-AAPVCESLQGGSPSTTVTVTALEALLCPSASVTQV B1MTW3_CALMO B1MTW3_CALMO HAANTAAMARS-----SVGAAEPH-AAPVCESLPGGSPGTTVTVTALEALLCPSATVTQV A9CB52_PAPAN A9CB52_PAPAN HVANTTAMARS-----SMGAGEPR-TAPACESLQGGSPSTTVTVTALEALLCPSATVTQV A6NEM2_HUMAN A6NEM2_HUMAN HAVSTAAMTRS-----SVGAGEPR-MAPVCESLQGGSPSTTVTVTALEALLCPSATVTQV HCFC1_HUMAN HCFC1_HUMAN HAVSTAAMTRS-----SVGAGEPR-MAPVCESLQGGSPSTTVTVTALEALLCPSATVTQV MATCH : : . CONSENSUS ????T?????????????G???????????E???????????T?????A???PS?TV??V

A8WIP5_DANRE A8WIP5_DANRE CSNPPCETHETGTTNTPTQASSSLGAGQSGTVQRVCSNPPCETHETGTTNTPTQASSSLG A5D6R2_DANRE A5D6R2_DANRE CSNPPCETHETGTTNTATTASSNMGGNQPGAVQRVCSNPPCETHETGTTNTATTASSSMG Q7SZY1_DANRE Q7SZY1_DANRE CSNPPCETHETGTTNTATTASSNMGGNQPGAVQRVCSNPPCETHETGTTNTATTASSSMG Q640G9_XENLA Q640G9_XENLA SSNLPCETHETNITSTTTDVTANVGTDQSQNVVNVCSDPRSETYETGTINTPTTARSNIG HCFC1_MESAU HCFC1_MESAU CSNPPCETHETGTTNTAT--TSNAGSAQ-----RVCSNPPCETHETGTTHTATTATSNGG HCFC1_MOUSE HCFC1_MOUSE CSNPPCETHETGTTNTAT--TSNAGSAQ-----RVCSNPPCETHETGTTHTATTATSNGG B1AUX1_MOUSE B1AUX1_MOUSE CSNPPCETHETGTTNTAT--TSNAGSAQ-----RVCSNPPCETHETGTTHTATTATSNGG B1AUX2_MOUSE B1AUX2_MOUSE CSNPPCETHETGTTNTAT--TSNAGSAQ-----RVCSNPPCETHETGTTHTATTATSNGG B2KII8_RHIFE B2KII8_RHIFE CSNPPCETHETGTTNTAT--TSNAGSAQ-----RVCSNPPCETHETGTTHTPTTATSGGG B7NZP5_RABIT B7NZP5_RABIT CSNPPCETHETGTTNTAT--TSNAGSAQ-----RVCSNPPCETHETGTTHTATTATSNGG B5FW89_OTOGA B5FW89_OTOGA CSNPPCETHETGTTHTAT--TSHAGSSQ-----RVCSNPPCETHETGTTHTATTATSSGG B0KWV2_CALJA B0KWV2_CALJA CSNPPCETHETGTTNTAT--TSNAGSAQ-----RVCSNPPCETHETGTTHTATTATSNGG B1MTW3_CALMO B1MTW3_CALMO CSNPPCETHETGTTNTAT--TSNAGSAQ-----RVCSNPPCETHETGTTHTATTATSNGG A9CB52_PAPAN A9CB52_PAPAN CSNPPCETHETGTTNTAT--TSNAGSAQ-----RVCSNPPCETHETGTTHTATTATSNGG A6NEM2_HUMAN A6NEM2_HUMAN CSNPPCETHETGTTNTAT--TSNAGSAQ-----RVCSNPPCETHETGTTHTATTATSNGG HCFC1_HUMAN HCFC1_HUMAN CSNPPCETHETGTTNTAT--TSNAGSAQ-----RVCSNPPCETHETGTTHTATTATSNGG MATCH .** *******. * *.* :: * * .***:* .**:**** :*.* * *. * CONSENSUS CSNPPCETHETGTTNTAT??TSN?G??Q?????RVCSNPPCETHETGTT?TATTA?S??G

A8WIP5_DANRE A8WIP5_DANRE AGQSGTVQRVCSNPPCET