Alignment of the gene Family HBG051894 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
A5PJZ7_BOVIN A5PJZ7_BOVIN -------------MTSTGQDSTTPKERRSRHNPHSPTHDSSITSKRGVKKSAILRSSPSL HDAC6_MOUSE HDAC6_MOUSE -------------MTSTGQDSST-RQRKSRHNPQSPLQESSATLKRGGKKCAVPHSSPNL Q3U4Q5_MOUSE Q3U4Q5_MOUSE -------------MTSTGQDSST-RQRKSRHNPQSPLQESSATLKRGGKKCAVPHSSPNL Q8CGC3_MOUSE Q8CGC3_MOUSE -------------MTSTGQDSST-RQRKSRHNPQSPLQESSATLKRGGKKCAVPHSSPNL B1AUA6_MOUSE B1AUA6_MOUSE -------------MTSTGQDSST-RQRKSRHNPQSPLQESSATLKRGGKKCAVPHSSPNL Q3UG37_MOUSE Q3UG37_MOUSE -------------MTSTGQDSST-RQRKSRHNPQSPLQESSATLKRGGKKCAVPHSSPNL B3KY98_HUMAN B3KY98_HUMAN ------------------------------------------------------------ B3KNA1_HUMAN B3KNA1_HUMAN -------------MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSIPNL Q4R496_MACFA Q4R496_MACFA ------------------------------------------------------------ Q9NZS3_HUMAN Q9NZS3_HUMAN ------------------------------------------------------------ Q9NSW6_HUMAN Q9NSW6_HUMAN -------------MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSIPNL B3KMC3_HUMAN B3KMC3_HUMAN ------------------------------------------------------------ Q6NT75_HUMAN Q6NT75_HUMAN -------------MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSIPNL B4DZH6_HUMAN B4DZH6_HUMAN SGANRGRGQASSTMTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSIPNL HDAC6_HUMAN HDAC6_HUMAN -------------MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSIPNL B4DZN1_HUMAN B4DZN1_HUMAN -----------------------MRGRGSKLVMPWTLTLLSDSQKRNIKKGAVPRSIPNL Q7L3E5_HUMAN Q7L3E5_HUMAN ------------------------------------------------------------ B3KVK5_HUMAN B3KVK5_HUMAN ------------------------------------------------------------ B3KT76_HUMAN B3KT76_HUMAN -------------MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSIPNL A7YT55_DANRE A7YT55_DANRE ------------------------------------------------------------ Q7ZYF0_XENLA Q7ZYF0_XENLA ---------------MASPQDPTAVPPRGLTGASRSPVTPACSMGKPRKKGASPQGPQSL MATCH CONSENSUS ????????????????????????????????????????????????????????????

A5PJZ7_BOVIN A5PJZ7_BOVIN AEVKKKGRMKKLSQTAEQDLIMGLQGLNLNLESRTLSGTGLVFDEQLNEFHCLWDDSFPE HDAC6_MOUSE HDAC6_MOUSE AEVKKKGKMKKLSQPAEEDLVVGLQGLDLNPETRVPVGTGLVFDEQLNDFHCLWDDSFPE Q3U4Q5_MOUSE Q3U4Q5_MOUSE AEVKKKGKMKKLSQPAEEDLVVGLQGLDLNPETRVPVGTGLVFDEQLNDFHCLWDDSFPE Q8CGC3_MOUSE Q8CGC3_MOUSE AEVKKKGKMKKLSQPAEEDLVVGLQGLDLNPETRVPVGTGLVFDEQLNDFHCLWDDSFPE B1AUA6_MOUSE B1AUA6_MOUSE AEVKKKGKMKKLSQPAEEDLVVGLQGLDLNPETRVPVGTGLVFDEQLNDFHCLWDDSFPE Q3UG37_MOUSE Q3UG37_MOUSE AEVKKKGKMKKLSQPAEEDLVVGLQGLDLNPETRVPVGTGLVFDEQLNDFHCLWDDSFPE B3KY98_HUMAN B3KY98_HUMAN ------------------------------------------------------------ B3KNA1_HUMAN B3KNA1_HUMAN AEVKKKGKMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSFPE Q4R496_MACFA Q4R496_MACFA ------------------------------------------------------------ Q9NZS3_HUMAN Q9NZS3_HUMAN ------------------------------------------------------------ Q9NSW6_HUMAN Q9NSW6_HUMAN AEVKKKGKMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSFPE B3KMC3_HUMAN B3KMC3_HUMAN ------------------------------------------------------------ Q6NT75_HUMAN Q6NT75_HUMAN AEVKKKGKMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSFPE B4DZH6_HUMAN B4DZH6_HUMAN AEVKKKGKMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSFPE HDAC6_HUMAN HDAC6_HUMAN AEVKKKGKMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSFPE B4DZN1_HUMAN B4DZN1_HUMAN AEVKKRGKMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSFPE Q7L3E5_HUMAN Q7L3E5_HUMAN ------------------------------------------------------------ B3KVK5_HUMAN B3KVK5_HUMAN ------------------------------------------------------------ B3KT76_HUMAN B3KT76_HUMAN AEVKKKGKMKKLGQVMEE------------------------------------------ A7YT55_DANRE A7YT55_DANRE ------------------------------------------------------------ Q7ZYF0_XENLA Q7ZYF0_XENLA QEVKKRGH--RMKRSPDQQLCDQLEGLNL-LAEAAVQGTGLVYDEQMAHNYCLWDENFPE MATCH CONSENSUS ????????????????????????????????????????????????????????????

A5PJZ7_BOVIN A5PJZ7_BOVIN RPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEEELHVL HDAC6_MOUSE HDAC6_MOUSE SPERLHAIREQLILEGLLGRCVSFQAWFAEKEELMLVHSLEYIDLMETTQYMNEGELRVL Q3U4Q5_MOUSE Q3U4Q5_MOUSE SPERLHAIREQLILEGLLGRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVL Q8CGC3_MOUSE Q8CGC3_MOUSE SPERLHAIREQLILEGLLGRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVL B1AUA6_MOUSE B1AUA6_MOUSE SPERLHAIREQLILEGLLGRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVL Q3UG37_MOUSE Q3UG37_MOUSE SPERLHAIREQLILEGLLGRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVL B3KY98_HUMAN B3KY98_HUMAN ------------------------------------------------------------ B3KNA1_HUMAN B3KNA1_HUMAN GPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVL Q4R496_MACFA Q4R496_MACFA ------------------------------------------------------------ Q9NZS3_HUMAN Q9NZS3_HUMAN ------------------------------------------NSGMETTQYMNEGELRVL Q9NSW6_HUMAN Q9NSW6_HUMAN GPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHR------METTQYMNEGELRVL B3KMC3_HUMAN B3KMC3_HUMAN ------------------------------------------------------------ Q6NT75_HUMAN Q6NT75_HUMAN GPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVL B4DZH6_HUMAN B4DZH6_HUMAN GPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVL HDAC6_HUMAN HDAC6_HUMAN GPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVL B4DZN1_HUMAN B4DZN1_HUMAN GPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVL Q7L3E5_HUMAN Q7L3E5_HUMAN ---------------------------------------------METTQYMNEGELRVL B3KVK5_HUMAN B3KVK5_HUMAN ------------------------------------------------------------ B3KT76_HUMAN B3KT76_HUMAN ------------------------------------------------------------ A7YT55_DANRE A7YT55_DANRE ------------------------------------------------------------ Q7ZYF0_XENLA Q7ZYF0_XENLA CPGRIWAVRDKMAEYGLAERCVAVPAREASEEEILLIHSPQYVALMRSTQKMTMDELRAL MATCH CONSENSUS ????????????????????????????????????????????????????????????

A5PJZ7_BOVIN A5PJZ7_BOVIN ADTYDSVYLHPNSYTCACLASGSVLRLVDAVLEAEIRNGMAIIRPPGHHAQHSLMDGYCM HDAC6_MOUSE HDAC6_MOUSE AETYDSVYLHPNSYSCACLATGSVLRLVDALMGAEIRNGMAVIRPPGHHAQHNLMDGYCM Q3U4Q5_MOUSE Q3U4Q5_MOUSE AETYDSVYLHPNSYSCACLATGSVLRLVDALMGAEIRNGMAVIRPPGHHAQHNLMDGYCM Q8CGC3_MOUSE Q8CGC3_MOUSE AETYDSVYLHPNSYSCACLATGSVLRLVDALMGAEIRNGMAVIRPPGHHAQHNLMDGYCM B1AUA6_MOUSE B1AUA6_MOUSE AETYDSVYLHPNSYSCACLATGSVLRLVDALMGAEIRNGMAVIRPPGHHAQHNLMDGYCM Q3UG37_MOUSE Q3UG37_MOUSE AETYDSVYLHPNSYSCACLATGSVLRLVDALMGAEIRNGMAVIRPPGHHAQHNLMDGYCM B3KY98_HUMAN B3KY98_HUMAN ------------------------------------------------------------ B3KNA1_HUMAN B3KNA1_HUMAN ADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIGPPGHHAQHSLMDGYCM Q4R496_MACFA Q4R496_MACFA ------------------------------------------------------------ Q9NZS3_HUMAN Q9NZS3_HUMAN ADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCM Q9NSW6_HUMAN Q9NSW6_HUMAN ADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCM B3KMC3_HUMAN B3KMC3_HUMAN ------------------------------------------------------------ Q6NT75_HUMAN Q6NT75_HUMAN ADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCM B4DZH6_HUMAN B4DZH6_HUMAN ADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCM HDAC6_HUMAN HDAC6_HUMAN ADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCM B4DZN1_HUMAN B4DZN1_HUMAN ADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCM Q7L3E5_HUMAN Q7L3E5_HUMAN ADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCM B3KVK5_HUMAN B3KVK5_HUMAN -MWYALSYYHHYYYS--------------------------------------------- B3KT76_HUMAN B3KT76_HUMAN ------------------------------------------------------------ A7YT55_DANRE A7YT55_DANRE --------LHPGFFSSACLSVGSVLQLVDKVMTSQLRNGFSINRPPGHHAQADKMNGFCM Q7ZYF0_XENLA Q7ZYF0_XENLA SDRYDSVYLHPTSFTCASLAVGSVLQLVDRVQHGEIRNGLAVVRPPGHHAHTDQMNGYCM MATCH CONSENSUS ?????????H??????????????????????????????????????????????????

A5PJZ7_BOVIN A5PJZ7_BOVIN FNHVAVAARYAQQKHDIQRVLIVDWDVHHGQGIQFAFDQDPSVLYFSIHRYEQGRFWPHL HDAC6_MOUSE HDAC6_MOUSE FNHLAVAARYAQKKHRIQRVLIVDWDVHHGQGTQFIFDQDPSVLYFSIHRYEHGRFWPHL Q3U4Q5_MOUSE Q3U4Q5_MOUSE FNHLAVAARYAQKKHRIQRVLIVDWDVHHGQGTQFIFDQDPSVLYFSIHRYEHGRFWPHL Q8CGC3_MOUSE Q8CGC3_MOUSE FNHLAVAARYAQKKHRIQRVLIVDWDVHHGQGTQFIFDQDPSVLYFSIHRYEHGRFWPHL B1AUA6_MOUSE B1AUA6_MOUSE FNHLAVAARYAQKKHRIQRVLIVDWDVHHGQGTQFIFDQDPSVLYFSIHRYEHGRFWPHL Q3UG37_MOUSE Q3UG37_MOUSE FNHLAVAARYAQKKHRIQRVLIVDWDVHHGQGTQFIFDQDPSVLYFSIHRYEHGRFWPHL B3KY98_HUMAN B3KY98_HUMAN ------------------------------------------------------------ B3KNA1_HUMAN B3KNA1_HUMAN FNHVAVAARYAQQKHRIRRVLIVDWDAHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHL Q4R496_MACFA Q4R496_MACFA ------------------------------------------------------------ Q9NZS3_HUMAN Q9NZS3_HUMAN FNHVAVAARYAQQKHRIRRVLILDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHL Q9NSW6_HUMAN Q9NSW6_HUMAN FNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHL B3KMC3_HUMAN B3KMC3_HUMAN ------------------------------------------------------------ Q6NT75_HUMAN Q6NT75_HUMAN FNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHL B4DZH6_HUMAN B4DZH6_HUMAN FNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHL HDAC6_HUMAN HDAC6_HUMAN FNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHL B4DZN1_HUMAN B4DZN1_HUMAN FNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHL Q7L3E5_HUMAN Q7L3E5_HUMAN FNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHL B3KVK5_HUMAN B3KVK5_HUMAN -------------------------------------------------LVMSGPFLIPL B3KT76_HUMAN B3KT76_HUMAN ------------------------------------------------------------ A7YT55_DANRE A7YT55_DANRE FNNLAIAARYAQKRHRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSVHRYEDGSFWPHL Q7ZYF0_XENLA Q7ZYF0_XENLA FNQLAIAARYAQLTYGAKRVLIVDWDVHHGQGTQFIFESDPSVLYFSVHRYDNGGFWPHL MATCH CONSENSUS ?????????????????????????????????????????????????????G?F???L

A5PJZ7_BOVIN A5PJZ7_BOVIN KASNWSTTGLGQGQGYTINVPWNQVGMQDADYIAAFLHVLLPVAFEFQPQLVLVAAGFDA HDAC6_MOUSE HDAC6_MOUSE KASNWSTIGFGQGQGYTINVPWNQTGMRDADYIAAFLHILLPVASEFQPQLVLVAAGFDA Q3U4Q5_MOUSE Q3U4Q5_MOUSE KASNWSTIGFGQGQGYTINVPWNQTGMRDADYIAAFLHILLPVASEFQPQLVLVAAGFDA Q8CGC3_MOUSE Q8CGC3_MOUSE KASNWSTIGFGQGQGYTINVPWNQTGMRDADYIAAFLHILLPVASEFQPQLVLVAAGFDA B1AUA6_MOUSE B1AUA6_MOUSE KASNWSTIGFGQGQGYTINVPWNQTGMRDADYIAAFLHILLPVASEFQPQLVLVAAGFDA Q3UG37_MOUSE Q3UG37_MOUSE KASNWSTIGFGQGQGYTINVPWNQTGMRDADYIAAFLHILLPVASEFQPQLVLVAAGFDA B3KY98_HUMAN B3KY98_HUMAN ------------------------------------------------------------ B3KNA1_HUMAN B3KNA1_HUMAN KASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDA Q4R496_MACFA Q4R496_MACFA ------------------------------------------------------------ Q9NZS3_HUMAN Q9NZS3_HUMAN KASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDA Q9NSW6_HUMAN Q9NSW6_HUMAN KASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDA B3KMC3_HUMAN B3KMC3_HUMAN ------------------------------------------------------------ Q6NT75_HUMAN Q6NT75_HUMAN KASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDA B4DZH6_HUMAN B4DZH6_HUMAN KASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDA HDAC6_HUMAN HDAC6_HUMAN KASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDA B4DZN1_HUMAN B4DZN1_HUMAN KASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDA Q7L3E5_HUMAN Q7L3E5_HUMAN KASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDA B3KVK5_HUMAN B3KVK5_HUMAN HNS------LPQ------------------------------------------------ B3KT76_HUMAN B3KT76_HUMAN ------------------------------------------------------------ A7YT55_DANRE A7YT55_DANRE KESDSSSVGSGAGQGYNINLPWNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDA Q7ZYF0_XENLA Q7ZYF0_XENLA KESASSAVGKERGERFNVNVAWNKTRMSDADYIHVFLNVLLPVAYEFQPHLVLVAAGFDS MATCH CONSENSUS ??S?????????????????????????????????????????????????????????

A5PJZ7_BOVIN A5PJZ7_BOVIN LQGDPK---GEMAATPAGFAQLTHLLMGLAEGKLILSLEGGYNLHSLAEGVSATLHTLLG HDAC6_MOUSE HDAC6_MOUSE LHGDPK---GEMAATPAGFAHLTHLLMGLAGGKLILSLEGGYNLRALAKGISASLHTLLG Q3U4Q5_MOUSE Q3U4Q5_MOUSE LHGDPK---GEMAATPAGFAHLTHLLMGLAGGKLILSLEGGYNLRALAKGVSASLHTLLG Q8CGC3_MOUSE Q8CGC3_MOUSE LHGDPKSLQGEMAATPAGFAHLTHLLMGLAGGKLILSLEGGYNLRALAKGVSASLHTLLG B1AUA6_MOUSE B1AUA6_MOUSE LHGDPK---GEMAATPAGFAHLTHLLMGLAGGKLILSLEGGYNLRALAKGVSASLHTLLG Q3UG37_MOUSE Q3UG37_MOUSE LHGDPK---GEMAATPAGFAHLTHLLMGLAGGKLILSLEGGYNLRALAKGVSASLHTLLG B3KY98_HUMAN B3KY98_HUMAN ------------------------------------------------------------ B3KNA1_HUMAN B3KNA1_HUMAN PQGDPK---GEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLG Q4R496_MACFA Q4R496_MACFA ------------------------------------------------------------ Q9NZS3_HUMAN Q9NZS3_HUMAN LQGDPK---GEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLG Q9NSW6_HUMAN Q9NSW6_HUMAN LQGDPK---GEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLG B3KMC3_HUMAN B3KMC3_HUMAN ------------------------------------------------------------ Q6NT75_HUMAN Q6NT75_HUMAN LQGDPK---GEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLG B4DZH6_HUMAN B4DZH6_HUMAN LQGDPK---GEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLG HDAC6_HUMAN HDAC6_HUMAN LQGDPK---GEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLG B4DZN1_HUMAN B4DZN1_HUMAN LQGDPK---GEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLG Q7L3E5_HUMAN Q7L3E5_HUMAN LQGDPK---GEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLG B3KVK5_HUMAN B3KVK5_HUMAN ---------------------------------------GGYNLRALAEGVSASLHTLLG B3KT76_HUMAN B3KT76_HUMAN ------------------------------------------------------------ A7YT55_DANRE A7YT55_DANRE VIGDPK---GGMQVSPECFSILTHMLKGVAQGRLVLALEGGYNLQSTAEGVCASMRSLLG Q7ZYF0_XENLA Q7ZYF0_XENLA VVGDPK---GEMSATPACFSHLTHLLMSLAQGRLILSLEGGYNQRSLAEGACASLKALLG MATCH CONSENSUS ???????????????????????????????????????GGYN????A?G??A????LLG

A5PJZ7_BOVIN A5PJZ7_BOVIN DPCPVLESPGAPCPSAQASLSCTLEALEPFWESLVRSVESLEEKDTVEKDDVEEKEEERL HDAC6_MOUSE HDAC6_MOUSE DPCPMLESCVVPCASAQISIYCTLEALEPFWEVLERSVETQ-EEDEVEEAVLEEEEEEGG Q3U4Q5_MOUSE Q3U4Q5_MOUSE DPCPMLESCVVPCASAQTSIYCTLEALEPFWEVLERSVETQ-EEDEVEEAVLEEEEEEGG Q8CGC3_MOUSE Q8CGC3_MOUSE DPCPMLESCVVPCASAQTSIYCTLEALEPFWEVLERSVETQ-EEDEVEEAVLEEEEEEGG B1AUA6_MOUSE B1AUA6_MOUSE DPCPMLESCVVPCASAQTSIYCTLEALEPFWEVLERSVETQ-EEDEVEEAVLEEEEEEGG Q3UG37_MOUSE Q3UG37_MOUSE DPCPMLESCVVPCASAQTSIYCTLEALEPFWEVLERSVETQ-EEDEVEEAVLEEEEEEGG B3KY98_HUMAN B3KY98_HUMAN MPGPHL---------SLSAISMSLS----------------------------------- B3KNA1_HUMAN B3KNA1_HUMAN DPCPMLESPGAPCRSAQASVSCALEAPEPFWEVLVRSTETV-ERDNMEEDNVEESEEEGP Q4R496_MACFA Q4R496_MACFA ------------------------------------------------------------ Q9NZS3_HUMAN Q9NZS3_HUMAN DPGPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETV-ERGHMGEDNVEESEEEGP Q9NSW6_HUMAN Q9NSW6_HUMAN DPCPMLESPGAPCRSAQTSVSCALEALEPFWEVLVRSTETV-ERDNMEEDNVEESEEEGP B3KMC3_HUMAN B3KMC3_HUMAN ------------------------------------------------------------ Q6NT75_HUMAN Q6NT75_HUMAN DPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETV-ERDNMEEDNVEESEEEGP B4DZH6_HUMAN B4DZH6_HUMAN DPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETV-ERDNMEEDNVEESEEEGP HDAC6_HUMAN HDAC6_HUMAN DPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETV-ERDNMEEDNVEESEEEGP B4DZN1_HUMAN B4DZN1_HUMAN DPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETV-ERDNMEEDNVEESEEEGP Q7L3E5_HUMAN Q7L3E5_HUMAN DPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETV-ERDNMEEDNVEESEEEGP B3KVK5_HUMAN B3KVK5_HUMAN DPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETV-ERDNMEEDNVEESEEEGP B3KT76_HUMAN B3KT76_HUMAN DPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETV-ERDNMEEDNVEESEEEGP A7YT55_DANRE A7YT55_DANRE DPCPHLPSSGAPCESALKSISKTISDLYPFWKSLQTF--------------------EGG Q7ZYF0_XENLA Q7ZYF0_XENLA DPCPRLTLPSAPCQSALDSMSDTISAHCSLWKMLQDYESE--GEPIIEPQSAKDGPPEGT MATCH CONSENSUS DPCP?L?S???PC?SA??S????L?A??PFW??L???????????????????????EG?

A5PJZ7_BOVIN A5PJZ7_BOVIN PQSP-------ELSVPIWPVLQAR-----TGLVYDQQMMDHHNLWDNYHPEMPQRIHFIM HDAC6_MOUSE HDAC6_MOUSE WEAT-------ALPMDTWPLLQNR-----TGLVYDEKMMSHCNLWDNHHPETPQRILRIM Q3U4Q5_MOUSE Q3U4Q5_MOUSE WEAT-------ALPMDTWPLLQNR-----TGLVYDEKMMSHCNLWDNHHPETPQRILRIM Q8CGC3_MOUSE Q8CGC3_MOUSE WEAT-------ALPMDTWPLLQNR-----TGLVYDEKMMSHCNLWDNHHPETPQRILRIM B1AUA6_MOUSE B1AUA6_MOUSE WEAT-------ALPMDTWPLLQNR-----TGLVYDEKMMSHCNLWDNHHPETPQRILRIM Q3UG37_MOUSE Q3UG37_MOUSE WEAT-------ALPMDTWPLLQNR-----TGLVYDEKMMSHCNLWDNHHPETPQRILRIM B3KY98_HUMAN B3KY98_HUMAN ------------------------------------------------------------ B3KNA1_HUMAN B3KNA1_HUMAN WEPP-------VLPILTWPVLQSR-----TGLVYDQNMMNHCNLWDSHHPEVPQRILRIM Q4R496_MACFA Q4R496_MACFA ------------------------------------------------------------ Q9NZS3_HUMAN Q9NZS3_HUMAN WEPP-------VLPILTWPVLTSR-----TGLVYDQNMMNHCNLWDSHHPEVPQRILRIM Q9NSW6_HUMAN Q9NSW6_HUMAN WEPP-------VLPILTWPVLQSR-----TGLVYDQNMMNHCNLWDSHHPEVPQRILRIM B3KMC3_HUMAN B3KMC3_HUMAN --------------------------------------MNHCNLWDSHHPEVPQRILRIM Q6NT75_HUMAN Q6NT75_HUMAN WEPP-------VLPILTWPVLQSR-----TGLVYDQNMMNHCNLWDSHHPEVPQRILRIM B4DZH6_HUMAN B4DZH6_HUMAN WEPP-------VLPILTWPVLQSR-----TGLVYDQNMMNHCNLWDSHHPEVPQRILRIM HDAC6_HUMAN HDAC6_HUMAN WEPP-------VLPILTWPVLQSR-----TGLVYDQNMMNHCNLWDSHHPEVPQRILRIM B4DZN1_HUMAN B4DZN1_HUMAN WEPP-------VLPILTWPVLQSR-----TGLVYDQNMMNHCNLWDSHHPEVPQRILRIM Q7L3E5_HUMAN Q7L3E5_HUMAN WEPP-------VLPILTWPVLQSR-----TGLVYDQNMMNHCNLWDSHHPEVPQRILRIM B3KVK5_HUMAN B3KVK5_HUMAN WEPP-------VLPILTWPVLQSR-----TGLVYDQNMMNHCNLWDSHHPEVPQRILRIM B3KT76_HUMAN B3KT76_HUMAN WEPP-------VLPILTWPVLQSR-----TGLVYDQNMMNHCNLWDSHHPEVPQRILRIM A7YT55_DANRE A7YT55_DANRE PLSE-------VSPLPAPVCAEVKVSSPITGLVYDQRMMLHHNMWDSHHPELPQRISRIF Q7ZYF0_XENLA Q7ZYF0_XENLA DEPPLEKFLEQAMIEVMRKVPEQR-----TALVYDEQMMEHRNMWDCYHPESPQRINQIF MATCH CONSENSUS ???????????????????????R?????TGLVYD??MM?H?NLWD?HHPE?PQRI?RIM

A5PJZ7_BOVIN A5PJZ7_BOVIN HHLDELGLAKRCHSLPARPATDAELLTCHSAEHLERLRATEKMKTRELRREGANYDSIYI HDAC6_MOUSE HDAC6_MOUSE CHLEEVGLAARCLILPARPALGSELLTCHSAEYVEHLRTTEKMKTRDLHREGANFDSIYI Q3U4Q5_MOUSE Q3U4Q5_MOUSE CHLEEVGLAARCLILPARPALDSELLTCHSAEYVEHLRTTEKMKTRDLHREGANFDSIYI Q8CGC3_MOUSE Q8CGC3_MOUSE CHLEEVGLAARCLILPARPALDSELLTCHSAEYVEHLRTTEKMKTRDLHREGANFDSIYI B1AUA6_MOUSE B1AUA6_MOUSE CHLEEVGLAARCLILPARPALDSELLTCHSAEYVEHLRTTEKMKTRDLHREGANFDSIYI Q3UG37_MOUSE Q3UG37_MOUSE CHLEEVGLAARCLILPARPALDSELLTCHSAEYVEHLRTTEKMKTRDLHREGANFDSIYI B3KY98_HUMAN B3KY98_HUMAN -----------------------------------------------LH--------LFL B3KNA1_HUMAN B3KNA1_HUMAN CRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYI Q4R496_MACFA Q4R496_MACFA ------------------------------------------MKTRELHRESSNFDSIYI Q9NZS3_HUMAN Q9NZS3_HUMAN CRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYI Q9NSW6_HUMAN Q9NSW6_HUMAN CRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYI B3KMC3_HUMAN B3KMC3_HUMAN CRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYI Q6NT75_HUMAN Q6NT75_HUMAN CRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYI B4DZH6_HUMAN B4DZH6_HUMAN CRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYI HDAC6_HUMAN HDAC6_HUMAN CRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYI B4DZN1_HUMAN B4DZN1_HUMAN CRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYI Q7L3E5_HUMAN Q7L3E5_HUMAN CRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYI B3KVK5_HUMAN B3KVK5_HUMAN CRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYI B3KT76_HUMAN B3KT76_HUMAN CRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYI A7YT55_DANRE A7YT55_DANRE SRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFI Q7ZYF0_XENLA Q7ZYF0_XENLA KRHKDLGLLERCSRLPSRLATQKELQMCHSLSYIQKIEASAHMKPRDLHRLGDEYNSIYI MATCH *. ::: CONSENSUS ??LEE?GLA?RC??L??RPA???ELLTCHSAEY???LR?TEKMKTR?LHRE??NFDSIYI

A5PJZ7_BOVIN A5PJZ7_BOVIN CSSTFACAQLAAGAACRLVEAVLAGEVLNGVAVVRPPGHHAEPDAACGFCFFNSVAVAAR HDAC6_MOUSE HDAC6_MOUSE CPSTFACAKLATGAACRLVEAVLSGEVLNGIAVVRPPGHHAEPNAACGFCFFNSVAVAAR Q3U4Q5_MOUSE Q3U4Q5_MOUSE CPSTFACAKLATGAACRLVEAVLSGEVLNGIAVVRPPGHHAEPNAACGFCFFNSVAVAAR Q8CGC3_MOUSE Q8CGC3_MOUSE CPSTFACAKLATGAACRLVEAVLSGEVLNGIAVVRPPGHHAEPNAACGFCFFNSVAVAAR B1AUA6_MOUSE B1AUA6_MOUSE CPSTFACAKLATGAACRLVEAVLSGEVLNGIAVVRPPGHHAEPNAACGFCFFNSVAVAAR Q3UG37_MOUSE Q3UG37_MOUSE CPSTFACAKLATGAACRLVEAVLSGEVLNGIAVVRPPGHHAEPNAACGFCFFNSVAVAAR B3KY98_HUMAN B3KY98_HUMAN LPLSL--------------------------------------------YFFSSLL---- B3KNA1_HUMAN B3KNA1_HUMAN CPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAAR Q4R496_MACFA Q4R496_MACFA CPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAAR Q9NZS3_HUMAN Q9NZS3_HUMAN CPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAAR Q9NSW6_HUMAN Q9NSW6_HUMAN CPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAAR B3KMC3_HUMAN B3KMC3_HUMAN CPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAAR Q6NT75_HUMAN Q6NT75_HUMAN CPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAAR B4DZH6_HUMAN B4DZH6_HUMAN CPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAAR HDAC6_HUMAN HDAC6_HUMAN CPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAAR B4DZN1_HUMAN B4DZN1_HUMAN CPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAAR Q7L3E5_HUMAN Q7L3E5_HUMAN CPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAAR B3KVK5_HUMAN B3KVK5_HUMAN CPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAAR B3KT76_HUMAN B3KT76_HUMAN CPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAAR A7YT55_DANRE A7YT55_DANRE SNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTAR Q7ZYF0_XENLA Q7ZYF0_XENLA NSKSYHSARLAAGSTFNVVEAVVTGKAQNGIGIVRPPGHHAEPGEACGFCFFNTVALAAR MATCH : **.: CONSENSUS CPSTFACA?LATGAACRLVEAVLSGEVLNG?AVVRPPGHHAE??AACGFCFFNSVAVAAR

A5PJZ7_BOVIN A5PJZ7_BOVIN HAQAISGHA---LRILIVDWDIHHGNGTQHIFEEDPSVLYISLHRYDHGTFFPMGNEGAC HDAC6_MOUSE HDAC6_MOUSE HAQIIAGRA---LRILIVDWDVHHGNGTQHIFEDDPSVLYVSLHRYDRGTFFPMGDEGAS Q3U4Q5_MOUSE Q3U4Q5_MOUSE HAQIIAGRA---LRILIVDWDVHHGNGTQHIFEDDPSVLYVSLHRYDRGTFFPMGDEGAS Q8CGC3_MOUSE Q8CGC3_MOUSE HAQIIAGRA---LRILIVDWDVHHGNGTQHIFEDDPSVLYVSLHRYDRGTFFPMGDEGAS B1AUA6_MOUSE B1AUA6_MOUSE HAQIIAGRA---LRILIVDWDVHHGNGTQHIFEDDPSVLYVSLHRYDRGTFFPMGDEGAS Q3UG37_MOUSE Q3UG37_MOUSE HAQIIAGRA---LRILIVDWDVHHGNGTQHIFEDDPSVLYVSLHRYDRGTFFPMGDEGAS B3KY98_HUMAN B3KY98_HUMAN HFQSLL------LCLLVSRF-----------------CVSISLTCISMSSFVL------- B3KNA1_HUMAN B3KNA1_HUMAN HAQTISGHA---LRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGAS Q4R496_MACFA Q4R496_MACFA HAQAISGRA---LRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGAS Q9NZS3_HUMAN Q9NZS3_HUMAN HAQTISGHA---LRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGAS Q9NSW6_HUMAN Q9NSW6_HUMAN HAQTISGHA---LRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGAS B3KMC3_HUMAN B3KMC3_HUMAN HAQTISGHA---LRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGGEGAS Q6NT75_HUMAN Q6NT75_HUMAN HAQTISGHA---LRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGAS B4DZH6_HUMAN B4DZH6_HUMAN HAQTISGHA---LRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGAS HDAC6_HUMAN HDAC6_HUMAN HAQTISGHA---LRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGAS B4DZN1_HUMAN B4DZN1_HUMAN HAQTISGHA---LRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGAS Q7L3E5_HUMAN Q7L3E5_HUMAN HAQTISGHA---LRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGAS B3KVK5_HUMAN B3KVK5_HUMAN HAQTISGHA---LRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGAS B3KT76_HUMAN B3KT76_HUMAN HAQTISGHA---LRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGAS A7YT55_DANRE A7YT55_DANRE YAQSITRES---LRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANY Q7ZYF0_XENLA Q7ZYF0_XENLA YAQRLQSQSEDPLRVMILDWDVHHGNGTQHIFQEDASVLYMSLHRYDEGLFFPNSEDASH MATCH : * : * ::: : : :** . . *. CONSENSUS HAQ?I?G?A???LRILIVDWDVHHGNGTQH?FEDDPSVLYVSLHRYD?GTFFPMG?EGAS

A5PJZ7_BOVIN A5PJZ7_BOVIN TRIGKATGTGFTVNVAWNGPRMGDADYLAAWHRLV-LPVAYEFNPELVLVSAGFDAARGD HDAC6_MOUSE HDAC6_MOUSE SQVGRDAGIGFTVNVPWNGPRMGDADYLAAWHRLV-LPIAYEFNPELVLISAGFDAAQGD Q3U4Q5_MOUSE Q3U4Q5_MOUSE SQVGRDAGIGFTVNVPWNGPRMGDADYLAAWHRLV-LPIAYEFNPELVLISAGFDAAQGD Q8CGC3_MOUSE Q8CGC3_MOUSE SQVGRDAGIGFTVNVPWNGPRMGDADYLAAWHRLV-LPIAYEFNPELVLISAGFDAAQGD B1AUA6_MOUSE B1AUA6_MOUSE SQVGRDAGIGFTVNVPWNGPRMGDADYLAAWHRLV-LPIAYEFNPELVLISAGFDAAQGD Q3UG37_MOUSE Q3UG37_MOUSE SQVGRDAGIGFTVNVPWNGPRMGDADYLAAWHRLV-LPIAYEFNPELVLISAGFDAAQGD B3KY98_HUMAN B3KY98_HUMAN ----------FSMSLGRHHLLPTKSPYPHAYTSLLSLP---QFNPELVLVSAGFDAARGD B3KNA1_HUMAN B3KNA1_HUMAN SQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLV-LPIAYEFNPKLVLVSAGFDAARGD Q4R496_MACFA Q4R496_MACFA SQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLV-LPIAYEFNPELVLVSAGFDAARGD Q9NZS3_HUMAN Q9NZS3_HUMAN SQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLV-LPIAYEFNPELVLVSAGFDAARGD Q9NSW6_HUMAN Q9NSW6_HUMAN SQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLV-LPIAYEFNPELVLVSAGFDAARGD B3KMC3_HUMAN B3KMC3_HUMAN SQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLV-LPIAYEFNPELVLVSAGFDAARGD Q6NT75_HUMAN Q6NT75_HUMAN SQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLV-LPIAYEFNPELVLVSAGFDAARGD B4DZH6_HUMAN B4DZH6_HUMAN SQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLV-LPIAYEFNPELVLVSAGFDAARGD HDAC6_HUMAN HDAC6_HUMAN SQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLV-LPIAYEFNPELVLVSAGFDAARGD B4DZN1_HUMAN B4DZN1_HUMAN SQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLV-LPIAYEFNPELVLVSAGFDAARGD Q7L3E5_HUMAN Q7L3E5_HUMAN SQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLV-LPIAYEFNPELVLVSAGFDAARGD B3KVK5_HUMAN B3KVK5_HUMAN SQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLV-LPIAYEFNPELVLVSAGFDAARGD B3KT76_HUMAN B3KT76_HUMAN SQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLV-LPIAYEFNPELVLVSAGFDAARGD A7YT55_DANRE A7YT55_DANRE DKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLV-MPIAREFAPELVLVSAGFDAARGD Q7ZYF0_XENLA Q7ZYF0_XENLA DKVGIGKGAGYNVNIPWNGGKMGDVEYLMAFHRVV-MPIAYEFNPQLVLISAGFDAARGD MATCH :.:.: : . * *: :: :* :* *:***:*******:** CONSENSUS SQ?GR?AG?GFTVNV?WNGPRMGDADYLAAWHRLV?LPIAYEFNPELVL?SAGFDAA?GD

A5PJZ7_BOVIN A5PJZ7_BOVIN PLGGCQVSPEGYAHLTHQLMGLANGHIILILEGGYNLTSISESMAACTRSLLGDPLPLLT HDAC6_MOUSE HDAC6_MOUSE PLGGCQVTPEGYAHLTHLLMGLAGGRIILILEGGYNLASISESMAACTHSLLGDPPPQLT Q3U4Q5_MOUSE Q3U4Q5_MOUSE PLGGCQVTPEGYAHLTHLLMGLAGGRIILILEGGYNLASISESMAACTHSLLGDPPPQLT Q8CGC3_MOUSE Q8CGC3_MOUSE PLGGCQVTPEGYAHLTHLLMGLAGGRIILILEGGYNLASISESMAACTHSLLGDPPPQLT B1AUA6_MOUSE B1AUA6_MOUSE PLGGCQVTPEGYAHLTHLLMGLAGGRIILILEGGYNLASISESMAACTHSLLGDPPPQLT Q3UG37_MOUSE Q3UG37_MOUSE PLGGCQVTPEGYAHLTHLLMGLAGGRIILILEGGYNLASISESMAACTHSLLGDPPPQLT B3KY98_HUMAN B3KY98_HUMAN PLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLT B3KNA1_HUMAN B3KNA1_HUMAN PLGGCQVSPEGYAHLTLPIA--------------------------CLR----------- Q4R496_MACFA Q4R496_MACFA PLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISGSMAACTRSLLGDPPPLLT Q9NZS3_HUMAN Q9NZS3_HUMAN PLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLT Q9NSW6_HUMAN Q9NSW6_HUMAN PLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLT B3KMC3_HUMAN B3KMC3_HUMAN PLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLT Q6NT75_HUMAN Q6NT75_HUMAN PLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLT B4DZH6_HUMAN B4DZH6_HUMAN PLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLT HDAC6_HUMAN HDAC6_HUMAN PLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLT B4DZN1_HUMAN B4DZN1_HUMAN PLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLT Q7L3E5_HUMAN Q7L3E5_HUMAN PLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLT B3KVK5_HUMAN B3KVK5_HUMAN PLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLT B3KT76_HUMAN B3KT76_HUMAN PLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLT A7YT55_DANRE A7YT55_DANRE PLGGFQVTPEGYAHLTHQLMSLAAGRVLIILEGGYNLTSISESMSMCTSMLLGDSPPSLD Q7ZYF0_XENLA Q7ZYF0_XENLA PLGGCQVSPEGYAHMTHLLMSLAGGRVILVLEGGYNLTSISESMVMCTRSLLGDPPPVLS MATCH **** **:******:* : * CONSENSUS PLGGCQV?PEGYAHLTHLLMGLA?GRIILILEGGYNL?SISESMAACT?SLLGDPPP?LT

A5PJZ7_BOVIN A5PJZ7_BOVIN RLRPPLSGAQASITKTIQVHRRYWRSLRVMKRKNKEELSSSKLITKKPSQPASPG----L HDAC6_MOUSE HDAC6_MOUSE LLRPPQSGALVSISEVIQVHRKYWRSLRLSKMEDKEECSSSRLVVKKLPPTASPV----S Q3U4Q5_MOUSE Q3U4Q5_MOUSE LLRPPQSGALVSISEVIQVHRKYWRSLRLMKMEDKEECSSSRLVIKKLPPTASPV----S Q8CGC3_MOUSE Q8CGC3_MOUSE LLRPPQSGALVSISEVIQVHRKYWRSLRLMKMEDKEECSSSRLVIKKLPPTASPV----S B1AUA6_MOUSE B1AUA6_MOUSE LLRPPQSGALVSISEVIQVHRKYWRSLRLMKMEDKEECSSSRLVIKKLPPTASPV----S Q3UG37_MOUSE Q3UG37_MOUSE LLRPPQSGALVSISEVIQVHRKYWRSLRLMKMEDKEECSSSRLVIKKLPPTASPV----S B3KY98_HUMAN B3KY98_HUMAN LPRPPLSGALASITETIQVHRRYWRSLRVMKVEDREGPSSSKLVTKKAPQPAKPR----L B3KNA1_HUMAN B3KNA1_HUMAN ------------------------------------------------------------ Q4R496_MACFA Q4R496_MACFA LPRPPLSGALASITETIQVHRRYWRSLRVMKVEDREGPSSSKLVTKKAPQPAKPR----L Q9NZS3_HUMAN Q9NZS3_HUMAN LPRPPLSGALASITETIQVHARYWCSLRVMKVEDREGPSSSKLVTKKAPQPAKPR----L Q9NSW6_HUMAN Q9NSW6_HUMAN LPRPPLSGALASITETIQVHRRYWRCLRVMKVEDREGPSSSKLDTKKAPQPAKPR----L B3KMC3_HUMAN B3KMC3_HUMAN LPRPPLSGALASITETIQVHRRYWRSLRVMKVEDREGPSSSKLVTKKAPQPAKPR----L Q6NT75_HUMAN Q6NT75_HUMAN LPRPPLSGALASITETIQVHRRYWRSLRVMKVEDREGPSSSKLVTKKAPQPAKPR----L B4DZH6_HUMAN B4DZH6_HUMAN LPRPPLSGALASITETIQVHRRYWRSLRVMKVEDREGPSSSKLVTKKAPQPAKPR----L HDAC6_HUMAN HDAC6_HUMAN LPRPPLSGALASITETIQVHRRYWRSLRVMKVEDREGPSSSKLVTKKAPQPAKPR----L B4DZN1_HUMAN B4DZN1_HUMAN LPRPPLSGALASITETIQVHRRYWRSLRVMKVEDREGPSSSKLVTKKAPQPAKPR----L Q7L3E5_HUMAN Q7L3E5_HUMAN LPRPPLSGALASITETIQVHRRYWRSLRVMKVEDREGPSSSKLVTKKAPQPAKPR----L B3KVK5_HUMAN B3KVK5_HUMAN LPRPPLSGALASITETIQVHRRYWRSLRVMKVEDREGPSSSKLVTKKAPQPAKPR----L B3KT76_HUMAN B3KT76_HUMAN LPRPPLSGALASITETIQVHRRYWRSLRVMKVEDREGPSSSKLVTKKAPQPAKPR----L A7YT55_DANRE A7YT55_DANRE HLTPLKTSATVSINNVLRAHAPFWSSLRV-------------------NIPESLR----L Q7ZYF0_XENLA Q7ZYF0_XENLA DLRPPKSSALNSVCKVRQAHRKYWRSLRLNVVGPPPKSTQGAKNLQHSPMRNSPRKGRFA MATCH CONSENSUS L?RPP?SGAL?SI?E?IQVHR?YWRSLR?MK?ED?E??SSS?L??KK?P??A?P??????

A5PJZ7_BOVIN A5PJZ7_BOVIN ANVTTTVEGNILETGMGQ-----------------------------AASEASVKESTPD HDAC6_MOUSE HDAC6_MOUSE AKEMTTPKGKVPEESVRK-----------------------------TIAALPGKESTLG Q3U4Q5_MOUSE Q3U4Q5_MOUSE AKEMTTPKGKVPEESVRK-----------------------------TIAALPGKESTLG Q8CGC3_MOUSE Q8CGC3_MOUSE AKEMTTPKGKVPEESVRK-----------------------------TIAALPGKESTLG B1AUA6_MOUSE B1AUA6_MOUSE AKEMTTPKGKVPEESVRK-----------------------------TIAALPGKESTLG Q3UG37_MOUSE Q3UG37_MOUSE AKEMTTPKGKVPEESVRK-----------------------------TIAALPGKESTLG B3KY98_HUMAN B3KY98_HUMAN AERMTTREKKVLEAGMGK-----------------------------VTSASFGEESTPG B3KNA1_HUMAN B3KNA1_HUMAN ----------------GT--------------------------------------TTPA Q4R496_MACFA Q4R496_MACFA AERMTTREKKVLEAGMGK-----------------------------ITSASSGEESTPG Q9NZS3_HUMAN Q9NZS3_HUMAN AERMTTREKKVLEAGMGK-----------------------------VTSASFGEESTPG Q9NSW6_HUMAN Q9NSW6_HUMAN AERMTTREKKVLEAGMGK-----------------------------VTSASFGEESTPG B3KMC3_HUMAN B3KMC3_HUMAN AERMTTREKKVLEAGMGK-----------------------------VTSASFGEESTPG Q6NT75_HUMAN Q6NT75_HUMAN AERMTTREKKVLEAGMGK-----------------------------VTSASFGEESTPG B4DZH6_HUMAN B4DZH6_HUMAN AERMTTREKKVLEAGMGK-----------------------------VTSASFGEESTPG HDAC6_HUMAN HDAC6_HUMAN AERMTTREKKVLEAGMGK-----------------------------VTSASFGEESTPG B4DZN1_HUMAN B4DZN1_HUMAN AERMTTREKKVLEAGMGK-----------------------------VTSASFGEESTPG Q7L3E5_HUMAN Q7L3E5_HUMAN AERMTTREKKVLEAGMGK-----------------------------VTSASFGEESTPG B3KVK5_HUMAN B3KVK5_HUMAN AERMTTREKKVLEAGMGK-----------------------------VTSASFGEESTPG B3KT76_HUMAN B3KT76_HUMAN AERMTTREKKVLEAGMGK-----------------------------VTSASFGEESTPG A7YT55_DANRE A7YT55_DANRE SLPSPKPKGKCTPGGKGK-----------------------------KSPRQSTPSQSPG Q7ZYF0_XENLA Q7ZYF0_XENLA AEAGPLTESKISSQGASSPKKIPSEVTVTPLASPLSSVSIEETPIPLIPDSKFSPEEVAN MATCH CONSENSUS A??MTT???KV?E????K????????????????????????????????A??G?EST?G

A5PJZ7_BOVIN A5PJZ7_BOVIN QTESATAP---VE----LTQGQSS---DTATQGAA------------------------- HDAC6_MOUSE HDAC6_MOUSE QAKSKMAK---AV----LAQGQSS---EQAAKGTT--------------LDLATSKETVG Q3U4Q5_MOUSE Q3U4Q5_MOUSE QAKSKMAK---AV----LAQGQSS---EQAAKGTT--------------LDLATSKETVG Q8CGC3_MOUSE Q8CGC3_MOUSE QAKSKMAK---AV----LAQGQSS---EQAAKGTT--------------LDLATSKETVG B1AUA6_MOUSE B1AUA6_MOUSE QAKSKMAK---AV----LAQGQSS---EQAAKGTT--------------LDLATSKETVG Q3UG37_MOUSE Q3UG37_MOUSE QAKSKMAK---AV----LAQGQSS---EQAAKGTT--------------LDLATSKETVG B3KY98_HUMAN B3KY98_HUMAN QTNSETAV---VA----LTQDQPS---EAATGGATLAQTISEAAIGGAMLGQTTSEEAVG B3KNA1_HUMAN B3KNA1_HUMAN QKERGAAQ---------------------------------------------------- Q4R496_MACFA Q4R496_MACFA QTKSETAV---VA----LTQDQSS---EAATGGATLAQTISEAAAGGAMLGQTTSEEAVG Q9NZS3_HUMAN Q9NZS3_HUMAN QTNSETAV---VA----LTQDQPS---EAATGGATLAQTISEAAIGGAMLGQTTSEEAVG Q9NSW6_HUMAN Q9NSW6_HUMAN QTNSETAV---VA----LTQDQPS---EAATGGATLAQTISEAAIGGAMLGQTTSEEAVG B3KMC3_HUMAN B3KMC3_HUMAN QTNSETAV---VA----LTQDQPS---EAATGGATLAQTISEAAIGGAMLGQTTSEEAVG Q6NT75_HUMAN Q6NT75_HUMAN QTNSETAV---VA----LTQDQPS---EAATGGATLAQTISEAAIGGAMLGQTTSEEAVG B4DZH6_HUMAN B4DZH6_HUMAN QTNSETAV---VA----LTQDQPS---EAATGGATLAQTISEAAIGGAMLGQTTSEEAVG HDAC6_HUMAN HDAC6_HUMAN QTNSETAV---VA----LTQDQPS---EAATGGATLAQTISEAAIGGAMLGQTTSEEAVG B4DZN1_HUMAN B4DZN1_HUMAN QTNSETAV---VA----LTQDQPS---EAATGGATLAQTISEAAIGGAMLGQTTSEEAVG Q7L3E5_HUMAN Q7L3E5_HUMAN QTNSETAV---VA----LTQDQPS---EAATGGATLAQTISEAAIGGAMLGQTTSEEAVG B3KVK5_HUMAN B3KVK5_HUMAN QTNSETAV---VA----LTQDQPS---EAATGGATLAQTISEAAIGGAMLGQTTSEEAVG B3KT76_HUMAN B3KT76_HUMAN QTNSETAV---VA----LTQDQPS---EAATGGATLAQTISEAAIGGAMLGQTTSEEAVG A7YT55_DANRE A7YT55_DANRE QATHRPDQSGFDE----LTADLLSLNLNTSTSSNT------------------------- Q7ZYF0_XENLA Q7ZYF0_XENLA QFVSAETAVQFAAPQYKMSTEEVANKLASPQGLTSLESTSSQLVSNREAIAPAWEHETPK MATCH * CONSENSUS Q??S??A??????????L?Q?Q?S???E?A??G?T??????????????L???TS?E?VG

A5PJZ7_BOVIN A5PJZ7_BOVIN -----------------------------------------------------------L HDAC6_MOUSE HDAC6_MOUSE GATTDLWAS-------------------------------------------AAAPENFP Q3U4Q5_MOUSE Q3U4Q5_MOUSE GATTDLWAS-------------------------------------------AAAPESFP Q8CGC3_MOUSE Q8CGC3_MOUSE GATTDLWAS-------------------------------------------AAAPENFP B1AUA6_MOUSE B1AUA6_MOUSE GATTDLWAS-------------------------------------------AAAPENFP Q3UG37_MOUSE Q3UG37_MOUSE GATTDLWAS-------------------------------------------AAAPENFP B3KY98_HUMAN B3KY98_HUMAN GATPDQTTSEETVGGAILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGATL B3KNA1_HUMAN B3KNA1_HUMAN ------------------------------------------------------------ Q4R496_MACFA Q4R496_MACFA GATPDQTTSEKTVGGATLDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGATL Q9NZS3_HUMAN Q9NZS3_HUMAN GATPDQTTSEETVGGAILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTISEAAMEGATL Q9NSW6_HUMAN Q9NSW6_HUMAN GATPDQTTSEETVGGAILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGATL B3KMC3_HUMAN B3KMC3_HUMAN GATPDQTTSEETVGGAILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGATL Q6NT75_HUMAN Q6NT75_HUMAN GATPDQTTSEETVGGAILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGATL B4DZH6_HUMAN B4DZH6_HUMAN GATPDQTTSEETVGGAILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGATL HDAC6_HUMAN HDAC6_HUMAN GATPDQTTSEETVGGAILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGATL B4DZN1_HUMAN B4DZN1_HUMAN GATPDQTTSEETVGGAILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGATL Q7L3E5_HUMAN Q7L3E5_HUMAN GATPDQTTSEETVGGAILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGATL B3KVK5_HUMAN B3KVK5_HUMAN GATPDQTTSEETVGGAILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGATL B3KT76_HUMAN B3KT76_HUMAN GATPDQTTSEETVGGAILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGATL A7YT55_DANRE A7YT55_DANRE ----------------------------------------------------------SP Q7ZYF0_XENLA Q7ZYF0_XENLA SPPTADSQKVPMGGLVAAEDIADALAERGLTMEILGCSEQRENVCKCKASPQSLQHEDKL MATCH CONSENSUS GAT?D???S???????????????????????????????????????????AA??????

A5PJZ7_BOVIN A5PJZ7_BOVIN DQTISEG---ATGGAELIQNPPASCINNRIP----PALPVQGATAQTSPSKLM------- HDAC6_MOUSE HDAC6_MOUSE NQTTSVE---ALGETEP--TPPASHTNKQTT----GASPLQGVTAQQSLQL--------- Q3U4Q5_MOUSE Q3U4Q5_MOUSE NQTTSVE---ALGETEP--TPPASHTNKQTT----GASPLQGVTAQQSLQL--------- Q8CGC3_MOUSE Q8CGC3_MOUSE NQTTSVE---ALGETEP--TPPASHTNKQTT----GASPLQGVTAQQSLQL--------- B1AUA6_MOUSE B1AUA6_MOUSE NQTTSVE---ALGETEP--TPPASHTNKQTT----GASPLQGVTAQQSLQL--------- Q3UG37_MOUSE Q3UG37_MOUSE NQTTSVE---ALGETEP--TPPASHTNKQTT----GASPLQGVTAQQSLQL--------- B3KY98_HUMAN B3KY98_HUMAN DQTTSEE---APGGTELIQTPLASSTDHQTP----PTSPVQGTTPQISPSTLI------- B3KNA1_HUMAN B3KNA1_HUMAN -------------------------------------WPQEG------------------ Q4R496_MACFA Q4R496_MACFA DQTTSEE---APGGTELIQTPLASSTDHQTP----PTSPVQGTTPQISPSTLI------- Q9NZS3_HUMAN Q9NZS3_HUMAN DQTTSEE---APGGTELIQTPLASSTDHQTP----PTSPGQGTTPQISPSTLI------- Q9NSW6_HUMAN Q9NSW6_HUMAN DQTTSEE---APGGTELIQTPLASSTDHQTP----PTSPVQGTTPQISPSTLI------- B3KMC3_HUMAN B3KMC3_HUMAN DQTTSEE---APGGTELIQTPLASSTDHQTP----PTSPVQGTTPQISPSTLI------- Q6NT75_HUMAN Q6NT75_HUMAN DQTTSEE---APGGTELIQTPLASSTDHQTP----PTSPVQGTTPQISPSTLI------- B4DZH6_HUMAN B4DZH6_HUMAN DQTTSEE---APGGTELIQTPLASSTDHQTP----PTSPVQGTTPQISPSTLI------- HDAC6_HUMAN HDAC6_HUMAN DQTTSEE---APGGTELIQTPLASSTDHQTP----PTSPVQGTTPQISPSTLI------- B4DZN1_HUMAN B4DZN1_HUMAN DQTTSEE---APGGTELIQTPLASSTDHQTP----PTSPVQGTTPQISPSTLI------- Q7L3E5_HUMAN Q7L3E5_HUMAN DQTTSEE---APGGTELIQTPLASSTDHQTP----PTSPVQGTTPQISPSTLI------- B3KVK5_HUMAN B3KVK5_HUMAN DQTTSEE---APGGTELIQTPLASSTDHQTP----PTSPVQGTTPQISPSTLI------- B3KT76_HUMAN B3KT76_HUMAN DQTTSEE---APGGTELIQTPLASSTDHQTP----PTSPVQGTTPQISPSTLI------- A7YT55_DANRE A7YT55_DANRE ESVAVGG---ARRKVKPNTHRVSAGLESESPLKLNPEKAGAGDDTDVKAETPN------- Q7ZYF0_XENLA Q7ZYF0_XENLA LDVQSPGVRIASGKESEAPVPPCSTVEERPLEQILRDLQLSDDASSSSSIAMAHTADLDP MATCH . CONSENSUS ?QTTS?E???A?G?TE???TP?AS?T??QT???????SP?QG?T?Q?S????????????

A5PJZ7_BOVIN A5PJZ7_BOVIN --ANLRILDLDSTTQEPSE----------------EEGLLGEAAGGQDT-NESVPVQVFG HDAC6_MOUSE HDAC6_MOUSE --GVLSTLELSREAEEAHD---------------SEEGLLGEAAGGQDM-NSLMLTQGFG Q3U4Q5_MOUSE Q3U4Q5_MOUSE --GVLSALELSREAEEAHD---------------SEEGLLGEAAGGQDM-NSLMLTQGFG Q8CGC3_MOUSE Q8CGC3_MOUSE --GVLSTLELSREAEEAHD---------------SEEGLLGEAAGGQDM-NSLMLTQGFG B1AUA6_MOUSE B1AUA6_MOUSE --GVLSTLELSREAEEAHD---------------SEEGLLGEAAGGQDM-NSLMLTQGFG Q3UG37_MOUSE Q3UG37_MOUSE --GVLSTLELSREAEEAHD---------------SEEG---------------------- B3KY98_HUMAN B3KY98_HUMAN --GSLRTLELGSESQGASE-----------SQAPGEENLLGEAAGGQDM-ADSMLMQ--G B3KNA1_HUMAN B3KNA1_HUMAN --ADIMRITL---------------------------------AGGELT----------G Q4R496_MACFA Q4R496_MACFA --ENLRTLELGSKSQGASE-----------SQAPGEENLLGEAAGGQDM-ADSMLMQ--G Q9NZS3_HUMAN Q9NZS3_HUMAN --GSLRTLELGSESQGASE-----------SQAPGEENLLGEAAGGQDM-ADSMLMQ--G Q9NSW6_HUMAN Q9NSW6_HUMAN --GSLRTLELGSESQGASE-----------SQAPGEENLLGEAAGGQDM-ADSMLMQ--G B3KMC3_HUMAN B3KMC3_HUMAN --GSLRTLELGSESQGASE-----------SQAPGEENLLGEAAGGQDM-ADSMLMQ--G Q6NT75_HUMAN Q6NT75_HUMAN --GSLRTLELGSESQGASE-----------SQAPGEENLLGEAAGGQDM-ADSMLMQ--G B4DZH6_HUMAN B4DZH6_HUMAN --GSLRTLELGSESQGASE-----------SQAPGEENLLGEAAGGQDM-ADSMLMQ--G HDAC6_HUMAN HDAC6_HUMAN --GSLRTLELGSESQGASE-----------SQAPGEENLLGEAAGGQDM-ADSMLMQ--G B4DZN1_HUMAN B4DZN1_HUMAN --GSLRTLELGSESQGASE-----------SQAPGEENLLGEAAGGQDM-ADSMLMQ--G Q7L3E5_HUMAN Q7L3E5_HUMAN --GSLRTLELGSESQGASE-----------SQAPGEENLLGEAAGGQDM-ADSMLMQ--G B3KVK5_HUMAN B3KVK5_HUMAN --GSLRTLELGSESQGASE-----------SQAPGEENLLGEAAGGQDM-ADSMLMQ--G B3KT76_HUMAN B3KT76_HUMAN --GSLRTLELGSESQGASE-----------SQAPGEENLLGEAAGGQDM-ADSMLMQ--G A7YT55_DANRE A7YT55_DANRE --RSISEPVVTCDSSAVKD----------------QESLVLEAAGGNTV--QSVLERVFG Q7ZYF0_XENLA Q7ZYF0_XENLA RDRAIRKSFITTGRDTPEEEYTEGSYIQVANAPPNEQELLDEAAGGSEAGNSTIGFEVFL MATCH : : CONSENSUS ????L??LEL??????A??????????????????EE?LLGEAAGGQD??????L?Q??G

A5PJZ7_BOVIN A5PJZ7_BOVIN DHADTDEVMFYAVRPLLWCPHLAAVCPIPETGLNVTQPCQYCGTLQENWVCLSCYQVYCG HDAC6_MOUSE HDAC6_MOUSE DF--NTQDVFYAVTPLSWCPHLMAVCPIPAAGLDVSQPCKTCGTVQENWVCLTCYQVYCS Q3U4Q5_MOUSE Q3U4Q5_MOUSE DF--NTQDVFYAVTPLSWCPHLMAVCPIPAAGLDVSQPCKTCGTVQENWVCLTCYQVYCS Q8CGC3_MOUSE Q8CGC3_MOUSE DF--NTQDVFYAVTPLSWCPHLMAVCPIPAAGLDVSQPCKTCGTVQENWVCLTCYQVYCS B1AUA6_MOUSE B1AUA6_MOUSE DF--NTQDVFYAVTPLSWCPHLMAVCPIPAAGLDVSQPCKTCGTVQENWVCLTCYQVYCS Q3UG37_MOUSE Q3UG37_MOUSE ------------------------------------------------------------ B3KY98_HUMAN B3KY98_HUMAN SRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQVYCG B3KNA1_HUMAN B3KNA1_HUMAN RHGKVAYVIKYKL----------------------------------------------- Q4R496_MACFA Q4R496_MACFA SRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVRLSCYQVYCG Q9NZS3_HUMAN Q9NZS3_HUMAN SRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQVYCG Q9NSW6_HUMAN Q9NSW6_HUMAN SRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQVYCG B3KMC3_HUMAN B3KMC3_HUMAN SRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQVYCG Q6NT75_HUMAN Q6NT75_HUMAN SRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQVYCG B4DZH6_HUMAN B4DZH6_HUMAN SRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQVYCG HDAC6_HUMAN HDAC6_HUMAN SRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQVYCG B4DZN1_HUMAN B4DZN1_HUMAN SRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQVYCG Q7L3E5_HUMAN Q7L3E5_HUMAN SRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQVYCG B3KVK5_HUMAN B3KVK5_HUMAN SRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQVYCG B3KT76_HUMAN B3KT76_HUMAN SRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQVYCG A7YT55_DANRE A7YT55_DANRE AQA-TDVDTMYVVDPLPWCPHLESVRPVPAGGIDVFQPCEECGGEAENWICLFCYKVLCG Q7ZYF0_XENLA Q7ZYF0_XENLA NSMEDESDVGFAVMPLSWCPHLGSVCAVPRDGVDVSQPCAQCGSELENWLCLTCYQVLCG MATCH CONSENSUS ?????????FYAV?PL?WCPHL?AVCPIPA?GLDV?QPC??CGT?QENWVCL?CYQVYC?

A5PJZ7_BOVIN A5PJZ7_BOVIN RYINAHMLQHHEGSGHPLVLSYADLSAWCYHCQAYVHHKDLLAVKNIAHQNKFGEDIPHS HDAC6_MOUSE HDAC6_MOUSE RYVNAHMVCHHEASEHPLVLSCVDLSTWCYVCQAYVHQDDLQDVKNAAHQNKFGEDMPHS Q3U4Q5_MOUSE Q3U4Q5_MOUSE RYVNAHMVCHHEASEHPLVLSCVDLSTWCYVCQAYVHHEDLQDVKNAAHQNKFGEDMPHS Q8CGC3_MOUSE Q8CGC3_MOUSE RYVNAHMVCHHEASEHPLVLSCVDLSTWCYVCQAYVHHEDLQDVKNAAHQNKFGEDMPHS B1AUA6_MOUSE B1AUA6_MOUSE RYVNAHMVCHHEASEHPLVLSCVDLSTWCYVCQAYVHHEDLQDVKNAAHQNKFGEDMPHS Q3UG37_MOUSE Q3UG37_MOUSE ------------------------------------------------------------ B3KY98_HUMAN B3KY98_HUMAN RYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKNIAHQNKFGEDMPHP B3KNA1_HUMAN B3KNA1_HUMAN ------------------------------------------------------------ Q4R496_MACFA Q4R496_MACFA RYINGHMLQHHENSGHPLVLSYIDLSTWCYYCQAYVHHQALLDVKNIAHQNKFGEDMPHP Q9NZS3_HUMAN Q9NZS3_HUMAN RYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKNIAHQNKFGEDMPHP Q9NSW6_HUMAN Q9NSW6_HUMAN RYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKNIAHQNKFGEDMPHP B3KMC3_HUMAN B3KMC3_HUMAN RYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKNIAHQNKFGEDMPHP Q6NT75_HUMAN Q6NT75_HUMAN RYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKDIAHQNKFGEDMPHP B4DZH6_HUMAN B4DZH6_HUMAN RYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKNIAHQNKFGEDMPHP HDAC6_HUMAN HDAC6_HUMAN RYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKNIAHQNKFGEDMPHP B4DZN1_HUMAN B4DZN1_HUMAN RYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKNIAHQNKFGEDMPHP Q7L3E5_HUMAN Q7L3E5_HUMAN RYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKNIAHQNKFGEDMPHP B3KVK5_HUMAN B3KVK5_HUMAN RYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKNIAHQNKFGEDMPHP B3KT76_HUMAN B3KT76_HUMAN RYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKNIAHQNKFGEDMPHP A7YT55_DANRE A7YT55_DANRE RYVNQHMVTHGQESGHPVVLSFADLSVWCYACESYVHNKVLHEAKNAAHLVKFGEGIHPF Q7ZYF0_XENLA Q7ZYF0_XENLA RYVSQHMLSHGLTSGHHLVLSFSDLSVWCYGCESYVHNEALFPAKSAAYSSKFEE----- MATCH CONSENSUS RY?N?HM??HH??S?HPLVLS??DLS?WCY?CQAYVH???L??VKN?AHQNKFGED?PH?

A5PJZ7_BOVIN A5PJZ7_BOVIN D HDAC6_MOUSE HDAC6_MOUSE H Q3U4Q5_MOUSE Q3U4Q5_MOUSE H Q8CGC3_MOUSE Q8CGC3_MOUSE H B1AUA6_MOUSE B1AUA6_MOUSE H Q3UG37_MOUSE Q3UG37_MOUSE - B3KY98_HUMAN B3KY98_HUMAN H B3KNA1_HUMAN B3KNA1_HUMAN - Q4R496_MACFA Q4R496_MACFA H Q9NZS3_HUMAN Q9NZS3_HUMAN H Q9NSW6_HUMAN Q9NSW6_HUMAN H B3KMC3_HUMAN B3KMC3_HUMAN H Q6NT75_HUMAN Q6NT75_HUMAN H B4DZH6_HUMAN B4DZH6_HUMAN H HDAC6_HUMAN HDAC6_HUMAN H B4DZN1_HUMAN B4DZN1_HUMAN H Q7L3E5_HUMAN Q7L3E5_HUMAN H B3KVK5_HUMAN B3KVK5_HUMAN H B3KT76_HUMAN B3KT76_HUMAN H A7YT55_DANRE A7YT55_DANRE N Q7ZYF0_XENLA Q7ZYF0_XENLA - MATCH CONSENSUS ?


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