Alignment of the gene Family HBG052447 of HOVERGEN

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Isoforms are ON
MD12L_MOUSE MD12L_MOUSE AAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARN B7ZMI1_HUMAN B7ZMI1_HUMAN AAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARN MD12L_HUMAN MD12L_HUMAN AAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARN A2AGH8_MOUSE A2AGH8_MOUSE AAFGILSYEHRPLKRLRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKN A2AGH9_MOUSE A2AGH9_MOUSE AAFGILSYEHRPLKRLRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKN MED12_MOUSE MED12_MOUSE AAFGILSYEHRPLKRLRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKN B4DYQ3_HUMAN B4DYQ3_HUMAN AAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKN MED12_PANTR MED12_PANTR ------------------------------------------------------------ Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN ------------------------------------------------------------ MED12_HUMAN MED12_HUMAN AAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKN MED12_PONPY MED12_PONPY AAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKN MED12_DANRE MED12_DANRE AAFGVLSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKN Q4RTF3_TETNG Q4RTF3_TETNG AAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSARN MATCH CONSENSUS AAFG?LSYE?RPLKR?RLGPPDVYPQDPKQKEDELTA?NVKQGFNNQPA??GDEHGSA?N

MD12L_MOUSE MD12L_MOUSE IVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLA B7ZMI1_HUMAN B7ZMI1_HUMAN IVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLA MD12L_HUMAN MD12L_HUMAN IVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLA A2AGH8_MOUSE A2AGH8_MOUSE VNFNPAKISSNFSSIIAEKLRCNTLSDTGRRKSLMNQKDNFWLVTARSQSAINTWFTDLA A2AGH9_MOUSE A2AGH9_MOUSE VNFNPAKISSNFSSIIAEKLRCNTLSDTGRRKSLMNQKDNFWLVTARSQSAINTWFTDLA MED12_MOUSE MED12_MOUSE VNFNPAKISSNFSSIIAEKLRCNTLSDTGRRKSLMNQKDNFWLVTARSQSAINTWFTDLA B4DYQ3_HUMAN B4DYQ3_HUMAN VSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLA MED12_PANTR MED12_PANTR ------------------------------------------------------------ Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN ------------------------------------------------------------ MED12_HUMAN MED12_HUMAN VSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLA MED12_PONPY MED12_PONPY VSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLA MED12_DANRE MED12_DANRE VNFNSSKISSNFSSIIAEKLRCNTFPDTGKRKPQVNQKDNFWLVTARSQSSINNWFTDLA Q4RTF3_TETNG Q4RTF3_TETNG VNFNPSKISSNFSSIIAEKLRYNTFPDTGKRKPQVNQKDNFWLVTARSQSSINNWFTDLA MATCH CONSENSUS ???N??KI???FSSI?AEKL??NT??DTG??K???N?KDN?WLVTARSQS?I??WF?DLA

MD12L_MOUSE MD12L_MOUSE GNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQAP B7ZMI1_HUMAN B7ZMI1_HUMAN GNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQAP MD12L_HUMAN MD12L_HUMAN GNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQAP A2AGH8_MOUSE A2AGH8_MOUSE GTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAMSETKVKKKNTA A2AGH9_MOUSE A2AGH9_MOUSE GTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAMSETKVKKKNTA MED12_MOUSE MED12_MOUSE GTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAMSETKVKKKNTA B4DYQ3_HUMAN B4DYQ3_HUMAN GTKPLTQLAKKVSIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHV- MED12_PANTR MED12_PANTR --------------------------------MRAAWLIKMTCAYYAAISETKVKKRHV- Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN --------------------------------MRAAWLIKMTCAYYAAISETKVKKRHV- MED12_HUMAN MED12_HUMAN GTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHV- MED12_PONPY MED12_PONPY GTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHV- MED12_DANRE MED12_DANRE GTKPLTQLAKKVPIFSKKEEVFGYLAKYSVPVMRSAWMIKMTCAYHAAITENKMKKRHVI Q4RTF3_TETNG Q4RTF3_TETNG GTKPLTQLAKKVPIFSKKEEVFGYLAKYSVPVMRSAWMIKMTCAYHAAITETKVKKRHVI MATCH :*::*:*******::*::* *:**::. CONSENSUS G?KPL??LAKKV?I?SKKE?VF?YLAKY?VP??RA?WLIKMTCAYY?A?SE?K?KK????

MD12L_MOUSE MD12L_MOUSE DPNLEWTQISTRYLREQLVKISDFYHM----ASSTGDGPVPVPPEVEQAMKQWEYNEKLA B7ZMI1_HUMAN B7ZMI1_HUMAN DPNLEWTQISTRYLREQLAKISDFYHM----ASSTGDGPVPVPPEVEQAMKQWEYNEKLA MD12L_HUMAN MD12L_HUMAN DPNLEWTQISTRYLREQLAKISDFYHM----ASSTGDGPVPVPPEVEQAMKQWEYNEKLA A2AGH8_MOUSE A2AGH8_MOUSE DPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEMAIRQWDYNEKLA A2AGH9_MOUSE A2AGH9_MOUSE DPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEMAIRQWDYNEKLA MED12_MOUSE MED12_MOUSE DPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEMAIRQWDYNEKLA B4DYQ3_HUMAN B4DYQ3_HUMAN DPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYTEKLA MED12_PANTR MED12_PANTR DPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYTEKLA Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN DPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYTEKLA MED12_HUMAN MED12_HUMAN DPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYTEKLA MED12_PONPY MED12_PONPY DPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYTEKLA MED12_DANRE MED12_DANRE DPCIEWTPIITKYLWEQLQKVAEFYRQSP--SQGCGSPLPAPPAEVETAMKQWEYNEKLA Q4RTF3_TETNG Q4RTF3_TETNG DPCIEWTQIITKYLWEQLQKVAEFYRQFP--NQGCSSPPPAMPSDVDTAMKQWEYNEKLA MATCH ** *** * *:** *** *::::*: . .. . * :*: *::**:*.**** CONSENSUS DP??EWTQI?T?YL?EQL?K????Y??????????G????P?P??VE?A??QW?Y?EKLA

MD12L_MOUSE MD12L_MOUSE FHMFQEGMLEKHEYLTWILDVLEKIRPVDDSLLKLLLPLMLQYSDEFVQSAYLSRRLAYF B7ZMI1_HUMAN B7ZMI1_HUMAN FHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLML------------------- MD12L_HUMAN MD12L_HUMAN FHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYF A2AGH8_MOUSE A2AGH8_MOUSE LFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYF A2AGH9_MOUSE A2AGH9_MOUSE LFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYF MED12_MOUSE MED12_MOUSE LFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYF B4DYQ3_HUMAN B4DYQ3_HUMAN MFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYF MED12_PANTR MED12_PANTR MFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYF Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN MFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYF MED12_HUMAN MED12_HUMAN MFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYF MED12_PONPY MED12_PONPY MFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYF MED12_DANRE MED12_DANRE MFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLRLLLPLLLQYSGEFVQSAYLSRRLAYF Q4RTF3_TETNG Q4RTF3_TETNG MFMFQDGMLDRHEFLTWVLECFEKVRPGEDELLRFLLPLLLQYSGEFVQSAYLSRRLAYF MATCH :.***:***::**:***:*: :**:** :*.**::****:* CONSENSUS ??MFQ?GML??HE?LTW?L???EKIRP??D?LLKLLLPL?L?YS?EFVQSAYLSRRLAYF

MD12L_MOUSE MD12L_MOUSE CARRLSLLLSDSP--NLLAAHSPHMIIGTNNTSIGTPSPGTPGPGMSPVQLAFSDFLSCA B7ZMI1_HUMAN B7ZMI1_HUMAN ------------------------------------------------------------ MD12L_HUMAN MD12L_HUMAN CARRLSLLLSDSP--NLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCA A2AGH8_MOUSE A2AGH8_MOUSE CTRRLALQL------DGVSSHSSHVIAAQSTSSL-PTTPAPQPPTSSTPSTPFSDLLMCP A2AGH9_MOUSE A2AGH9_MOUSE CTRRLALQL------DGVSSHSSHVIAAQSTSSL-PTTPAPQPPTSSTPSTPFSDLLMCP MED12_MOUSE MED12_MOUSE CTRRLALQL------DGVSSHSSHVIAAQSTSSL-PTTPAPQPPTSSTPSTPFSDLLMCP B4DYQ3_HUMAN B4DYQ3_HUMAN CTRRLALQL------DGVSSHSSHVISAQSTSTL-PTTPAPQPPTSSTPSTPFSDLLMCP MED12_PANTR MED12_PANTR CTRRLALQL------DGVSSHSSHVISAQSTSTL-PTTPAPQPPTSSTPSTPFSDLLMCP Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN CTRRLALQL------DGVSSHSSHVISAQSTSTL-PTTPAPQPPTSSTPSTPFSDLLMCP MED12_HUMAN MED12_HUMAN CTRRLALQL------DGVSSHSSHVISAQSTSTL-PTTPAPQPPTSSTPSTPFSDLLMCP MED12_PONPY MED12_PONPY CTRRLALQL------DGVSSHSSHVISAQSTSTL-PTTPAPQPPTSSTPSTPFSDLLMCP MED12_DANRE MED12_DANRE CTRRLNLLLSDGSIGPGPGGHQAHGISAQQGNAL-PPTPTSQPAGGNQPQTPFTDFYICP Q4RTF3_TETNG Q4RTF3_TETNG CTRRLNLLLSDGSMGPGAGGHPGHSILAQQGNAL-PPTPTSQPSGGSQPQTPFTDFYICP MATCH CONSENSUS C?RRL?L?L???????????H??H?I????????????P???????S?????F?D???C?

MD12L_MOUSE MD12L_MOUSE QHGPLVYGLSCMLQTVTLCCPSALVWNYSTNENKISNPGSPLDLLQVAPSSLPMPGGNTA B7ZMI1_HUMAN B7ZMI1_HUMAN ------------------------------------------------------------ MD12L_HUMAN MD12L_HUMAN QHGPLVYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTA A2AGH8_MOUSE A2AGH8_MOUSE QHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKT-GSPLDHLPIAPSNLPMPEGNSA A2AGH9_MOUSE A2AGH9_MOUSE QHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKT-GSPLDHLPIAPSNLPMPEGNSA MED12_MOUSE MED12_MOUSE QHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKT-GSPLDHLPIAPSNLPMPEGNSA B4DYQ3_HUMAN B4DYQ3_HUMAN QHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKT-GSPLDHLPIAPSNLPMPEGNSA MED12_PANTR MED12_PANTR QHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKT-GSPLDHLPIAPSNLPMPEGNSA Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN QHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKT-GSPLDHLPIAPSNLPMPEGNSA MED12_HUMAN MED12_HUMAN QHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKT-GSPLDHLPIAPSNLPMPEGNSA MED12_PONPY MED12_PONPY QHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKT-GSPLDHLPIAPSNLPMPEGNSA MED12_DANRE MED12_DANRE QHRPVVFGLSCMLQSIVLCCPSALVWHYSLTDSRNKT-GSPLDLLPIAPSNLPMPGGNST Q4RTF3_TETNG Q4RTF3_TETNG QHRPIVYGLSCMLQSIVLCCPSALVWHYSLTDCRNKT-GSPLDLLPIAPSSLPMPGGNTA MATCH CONSENSUS QH?P?V?GLSC?LQ???LCCPSALVW?YS?????????GSPLD?L??APS?LPMP?GN?A

MD12L_MOUSE MD12L_MOUSE FNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTD B7ZMI1_HUMAN B7ZMI1_HUMAN ---QVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTD MD12L_HUMAN MD12L_HUMAN FNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTD A2AGH8_MOUSE A2AGH8_MOUSE FTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSD A2AGH9_MOUSE A2AGH9_MOUSE FTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSD MED12_MOUSE MED12_MOUSE FTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSD B4DYQ3_HUMAN B4DYQ3_HUMAN FTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSD MED12_PANTR MED12_PANTR FTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSD Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN FTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSD MED12_HUMAN MED12_HUMAN FTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSD MED12_PONPY MED12_PONPY FTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSD MED12_DANRE MED12_DANRE FNQQVRAKVREIEEQIKERGQAVEFRWSFDKCQETTAGFTISRVLHTLEVLDNHSFEKSD Q4RTF3_TETNG Q4RTF3_TETNG LTQQVRTKLREIEEQVKERGQAVEFRWSFDKCQETTAGFTIGRVLHTLEVLDSHSFEKSD MATCH ***::: *:*:*:*:**:***.*********:***.**.********** *.*:::* CONSENSUS F?QQVRA???E?EQQIK?RG?AVEVRWSFDKCQE?TAG?TI?RVLHTLEVLD?H?F?R?D

MD12L_MOUSE MD12L_MOUSE SSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKR B7ZMI1_HUMAN B7ZMI1_HUMAN SSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKR MD12L_HUMAN MD12L_HUMAN SSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKR A2AGH8_MOUSE A2AGH8_MOUSE FSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKR A2AGH9_MOUSE A2AGH9_MOUSE FSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKR MED12_MOUSE MED12_MOUSE FSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKR B4DYQ3_HUMAN B4DYQ3_HUMAN FSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKR MED12_PANTR MED12_PANTR FSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKR Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN FSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKR MED12_HUMAN MED12_HUMAN FSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKR MED12_PONPY MED12_PONPY FSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKR MED12_DANRE MED12_DANRE FSNSLDSLYNRIFGSGQSKDGHEMSPDDDAVVTLLCEWAVSCKRSGPHRAMVVAKLLEKR Q4RTF3_TETNG Q4RTF3_TETNG FNNSLDLLYNRIFGSGQSKDSHEMSPDDDAVVTLLCEWAVCCKRSGRHRAMVVAKLLEKR MATCH .**:: * ::** . .**.:*::.:*:***:*******.***** ****.******** CONSENSUS ?SNS???L???IF?????KD??E????D?AVV?LLCEWAVSCKRSG?HRAM?VAKLLEKR

MD12L_MOUSE MD12L_MOUSE QAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPALSDPNSECEKVE B7ZMI1_HUMAN B7ZMI1_HUMAN QAEIEAERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVE MD12L_HUMAN MD12L_HUMAN QAEIEAERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVE A2AGH8_MOUSE A2AGH8_MOUSE QAEIEAERCGESEAADEKGSVASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVE A2AGH9_MOUSE A2AGH9_MOUSE QAEIEAERCGESEAADEKGSVASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVE MED12_MOUSE MED12_MOUSE QAEIEAERCGESEAADEKGSVASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVE B4DYQ3_HUMAN B4DYQ3_HUMAN QAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVE MED12_PANTR MED12_PANTR QAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSENERVE Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN QAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVE MED12_HUMAN MED12_HUMAN QAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVE MED12_PONPY MED12_PONPY QAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVE MED12_DANRE MED12_DANRE QTEIEAERCGESEVVDEKGSVSSGSLSAATLPVFQDVLLQFLDTQAPVLTEPGNESERVE Q4RTF3_TETNG Q4RTF3_TETNG QAEIEAERCGDSEVVDEKGSVSSGSLSAATVPVFQDVLLQFLDTQAPTLTEPGNESERVE MATCH *:********:**. *** *::*.**:..: *:**:***:******* *::* .* *:** CONSENSUS QAEIEAERCGESE??DEK?S??S?SL???S?P?FQ?VLL?FLDTQAP?L?DP?SE?E?VE

MD12L_MOUSE MD12L_MOUSE FVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTAS-TGLRSPAGENSDEHYSKDHD-- B7ZMI1_HUMAN B7ZMI1_HUMAN FVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTAS-TRPRSPVGENADEHYSKDHD-- MD12L_HUMAN MD12L_HUMAN FVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTAS-TRPRSPVGENADEHYSKDHD-- A2AGH8_MOUSE A2AGH8_MOUSE FFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPTDDPERKEAEGS A2AGH9_MOUSE A2AGH9_MOUSE FFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPTDDPERKEAEGS MED12_MOUSE MED12_MOUSE FFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPTDDPERKEAEGS B4DYQ3_HUMAN B4DYQ3_HUMAN FFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPEHKEAEGS MED12_PANTR MED12_PANTR FFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDAEHKEAEGS Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN FFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPEHKEAEGS MED12_HUMAN MED12_HUMAN FFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPEHKEAEGS MED12_PONPY MED12_PONPY FFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPEHKEAEGS MED12_DANRE MED12_DANRE FSNLVLLFYELIRHDVFSHNIYMCTLISRGDLASNSHLPRPRSPSDEPSDESERKDQDAG Q4RTF3_TETNG Q4RTF3_TETNG FSNLVLLFCELIRHDVFSHNIYMCTLISRGDLASDSHLPRPRSPSDEPSDESERKDQEAG MATCH * ****** *:********: * *********: : . ** .: :*: *: : CONSENSUS F?NLVLLFCE?IRHDVFSH??Y?CTLISRGDL???A???RP?SP?????D????K?????

MD12L_MOUSE MD12L_MOUSE --MKME-------------------------------IFSP-MPGESCENINPSLSRRLS B7ZMI1_HUMAN B7ZMI1_HUMAN --VKME-------------------------------IFSP-MPGESCENANTSLGRRMS MD12L_HUMAN MD12L_HUMAN --VKME-------------------------------IFSP-MPGESCENANTSLGRRMS A2AGH8_MOUSE A2AGH8_MOUSE SSSKLEDPGLSESMDIDPSSSVLFEDMEKPD----FSLFSPTMP---CEGKGSPSPEKPD A2AGH9_MOUSE A2AGH9_MOUSE SSSKLEDPGLSESMDIDPSSSVLFEDMEKPD----FSLFSPTMP---CEGKGSPSPEKPD MED12_MOUSE MED12_MOUSE SSSKLEDPGLSESMDIDPSSSVLFEDMEKPD----FSLFSPTMP---CEGKGSPSPEKPD B4DYQ3_HUMAN B4DYQ3_HUMAN SSSKLEDPGLSESMDIDPSSSVLFEDMEKPD----FSLFSPTMP---CEGKGSPSPEKPD MED12_PANTR MED12_PANTR SSSKLEDPGLSESMDIDPSSSVLFEDMEKPD----FSLFSPTMP---CEGKGSPSPEKPD Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN SSSKLEDPGLSESMDIDPSSSVLFEDMEKPD----FSLFSPTMP---CEGKGSPSPEKPD MED12_HUMAN MED12_HUMAN SSSKLEDPGLSESMDIDPSSSVLFEDMEKPD----FSLFSPTMP---CEGKGSPSPEKPD MED12_PONPY MED12_PONPY SSSKLEDPGLSESMDIDPSSSVLFEDMEKPD----FSLFSPTMP---CEGKGSPSPEKPD MED12_DANRE MED12_DANRE SSVKMEDTGMSESMEIDHNSSANFDE-----------MFSPPMH---CESKGSPSPEKQA Q4RTF3_TETNG Q4RTF3_TETNG SNCKNE----AKSMEIDHNSSANFDEVQRDDNFSFADMFSPPMH---CESKGSPSPEKPP MATCH * * :*** * **. ... .: CONSENSUS ???K?E????????????????????????????????FSP?MP???CE???????????

MD12L_MOUSE MD12L_MOUSE VNGE-KLLKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKER B7ZMI1_HUMAN B7ZMI1_HUMAN VNCE-KLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKER MD12L_HUMAN MD12L_HUMAN VNCE-KLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKER A2AGH8_MOUSE A2AGH8_MOUSE VEKEVKPPAKEK-IEGTLGILYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQR A2AGH9_MOUSE A2AGH9_MOUSE VEKEVKPPAKEK-IEGTLGILYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQR MED12_MOUSE MED12_MOUSE VEKEVKPPAKEK-IEGTLGILYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQR B4DYQ3_HUMAN B4DYQ3_HUMAN VEKEVKPPPKEK-IEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQR MED12_PANTR MED12_PANTR VEKEVKPPPKEK-IEGTLGILYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQR Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN VEKEVKPPPKEK-IEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQR MED12_HUMAN MED12_HUMAN VEKEVKPPPKEK-IEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQR MED12_PONPY MED12_PONPY VEKEVKPPPKEK-IEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQR MED12_DANRE MED12_DANRE QEQESKSTAKDKGMDPAFPLVYEQPRHIQYATHFPIPQEESASHECNQRLVVLYGVGKQR Q4RTF3_TETNG Q4RTF3_TETNG PEQDSKAGSKDKGMDPAFPQLYDQPRHIQYATHFPIPQEESSSHECNQRLVVLYGVGKLR MATCH : : * ::* : : *: **:********* :**.******* ::*:**** * CONSENSUS V??E?K????EK??E??????YD??RH?QYATHFPIP??ES?SHECNQR???L?GVGK?R

MD12L_MOUSE MD12L_MOUSE DEARHQLKKITKDILKILNKKGTTESGV----------------GDEGQKARKTKQEVFP B7ZMI1_HUMAN B7ZMI1_HUMAN DEARHQLKKITKDILKILNKKSTTETGV----------------GDEGQKARKNKQETFP MD12L_HUMAN MD12L_HUMAN DEARHQLKKITKDILKILNKKSTTETGV----------------GDEGQKARKNKQETFP A2AGH8_MOUSE A2AGH8_MOUSE DDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFP A2AGH9_MOUSE A2AGH9_MOUSE DDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFP MED12_MOUSE MED12_MOUSE DDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFP B4DYQ3_HUMAN B4DYQ3_HUMAN DDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFP MED12_PANTR MED12_PANTR DDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFP Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN DDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFP MED12_HUMAN MED12_HUMAN DDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFP MED12_PONPY MED12_PONPY DDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFP MED12_DANRE MED12_DANRE DEARHAIKKITKDILKVLNRKSTAET-----------------GGEEGQKRKRSKPEAFP Q4RTF3_TETNG Q4RTF3_TETNG DEARHTIKKITKDILKVLNRKSTAETGKGSSHLS-----TVMFGGEEGQKRKKSKPEAFP MATCH *:*** :*********:**:*.*:*: *::*** ::.: *.** CONSENSUS D?ARH??KKITKDILK?LN?K?T?ET??????????????????G??GQK?R????E?FP

MD12L_MOUSE MD12L_MOUSE TPENVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPAL B7ZMI1_HUMAN B7ZMI1_HUMAN TLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPAL MD12L_HUMAN MD12L_HUMAN TLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPAL A2AGH8_MOUSE A2AGH8_MOUSE TAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSL A2AGH9_MOUSE A2AGH9_MOUSE TAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSL MED12_MOUSE MED12_MOUSE TAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSL B4DYQ3_HUMAN B4DYQ3_HUMAN TAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSL MED12_PANTR MED12_PANTR TAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSL Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN TAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSL MED12_HUMAN MED12_HUMAN TAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSL MED12_PONPY MED12_PONPY TAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSL MED12_DANRE MED12_DANRE TAEDIFSKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHIQFIFDLMEYSL Q4RTF3_TETNG Q4RTF3_TETNG TAEDIFSKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHIQFIFDLMEYSL MATCH * * :*:*:* **::******:*:*.********** * ******.:*:*:****** :* CONSENSUS T?E??F?K?Q?LS??DQHQVT?Q?S?NVLEQITSFA?G?SYHLPL??H?Q?IFDLME??L

MD12L_MOUSE MD12L_MOUSE NINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQT B7ZMI1_HUMAN B7ZMI1_HUMAN NINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQT MD12L_HUMAN MD12L_HUMAN NINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQT A2AGH8_MOUSE A2AGH8_MOUSE SISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQM A2AGH9_MOUSE A2AGH9_MOUSE SISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQM MED12_MOUSE MED12_MOUSE SISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQM B4DYQ3_HUMAN B4DYQ3_HUMAN SISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQM MED12_PANTR MED12_PANTR SISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQM Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN SISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQM MED12_HUMAN MED12_HUMAN SISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQM MED12_PONPY MED12_PONPY SISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQM MED12_DANRE MED12_DANRE NISGLIDFAIQLLNELSLVEAELLLKSSNLAGSYTTGLCLCIVAVLRRYHSCLILNPDQT Q4RTF3_TETNG Q4RTF3_TETNG NISGLIDFAIQLLNELSLVEAELLLKSSNLVGSYTTSLCLCIVAVLRRYHSCLILNPEQT MATCH .*.**************:**********.*.*****.**:*******:**:***** :* CONSENSUS ?I?GLIDFAIQLLNELSVVEAELLLKSS?L?GSYTT?LC?CIVAVLR?YH?CLILN?DQ?

MD12L_MOUSE MD12L_MOUSE AQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTI B7ZMI1_HUMAN B7ZMI1_HUMAN AQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTI MD12L_HUMAN MD12L_HUMAN AQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTI A2AGH8_MOUSE A2AGH8_MOUSE AQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTI A2AGH9_MOUSE A2AGH9_MOUSE AQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTI MED12_MOUSE MED12_MOUSE AQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTI B4DYQ3_HUMAN B4DYQ3_HUMAN AQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTI MED12_PANTR MED12_PANTR AQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTI Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN AQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTI MED12_HUMAN MED12_HUMAN AQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTI MED12_PONPY MED12_PONPY AQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTI MED12_DANRE MED12_DANRE AQVFDGLRIVVKSGVNPADCSSAERCILAYLYDLYTSCSHLKSKFGEIFSEFCSKVKNSI Q4RTF3_TETNG Q4RTF3_TETNG AQVFDGLRIVVKSGVNPADCSSAERCILAYLYDLYNSCSHLKNKFGEIFSEFCSKVKNSI MATCH ****:** *** :* :: **.************ *****:.***::**. *****::* CONSENSUS AQVFEGLCGVVKH??N?S??SS?ERCILAYLYDLY?SCSHL??KFG?LFS??CSKVK?TI

MD12L_MOUSE MD12L_MOUSE YNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKI---LNDNAANRYSFVCNTLMNV B7ZMI1_HUMAN B7ZMI1_HUMAN YNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKI---LSDNAANRYSFVCNTLMNV MD12L_HUMAN MD12L_HUMAN YNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKI---LSDNAANRYSFVCNTLMNV A2AGH8_MOUSE A2AGH8_MOUSE YCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKS---LSENPANRYSFVCNALMHV A2AGH9_MOUSE A2AGH9_MOUSE YCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKS---LSENPANRYSFVCNALMHV MED12_MOUSE MED12_MOUSE YCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKS---LSENPANRYSFVCNALMHV B4DYQ3_HUMAN B4DYQ3_HUMAN YCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKS---LSENPANRYSFVCNALMHV MED12_PANTR MED12_PANTR YCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKS---LSENPANRYSFVCNALMHV Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN YCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKS---LSENPANRYSFVCNALMHV MED12_HUMAN MED12_HUMAN YCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKS---LSENPANRYSFVCNALMHV MED12_PONPY MED12_PONPY YCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKS---LSENPANRYSFVCNALMHV MED12_DANRE MED12_DANRE YYNIDPSDSNMLWDQMFMIDAITNPTAHNLNHSMLGKITNELNDSPANRYSFVCNVLMDV Q4RTF3_TETNG Q4RTF3_TETNG YCNIDPSDSNMLWDPVFMVEAIANPSAHNFNHSMVGKI---LNDSKANRYSFVCNVLMDV MATCH * *: *::**: * **:: : **:*:.:.:: :** *.:. *********.**.* CONSENSUS Y?NV?P??SN?RW?P?FM?D??ENP?A????Y??LGK????L??N?ANRYSFVCN?LM?V

MD12L_MOUSE MD12L_MOUSE CMGHQDAG---------------------------------RINDIANFSSELTACCTVL B7ZMI1_HUMAN B7ZMI1_HUMAN CMGHQDAG---------------------------------RINDIANFSSELTACCTVL MD12L_HUMAN MD12L_HUMAN CMGHQDAG---------------------------------RINDIANFSSELTACCTVL A2AGH8_MOUSE A2AGH8_MOUSE CVGHHDPD---------------------------------RVNDIAILCAELTGYCKSL A2AGH9_MOUSE A2AGH9_MOUSE CVGHHDPD---------------------------------RVNDIAILCAELTGYCKSL MED12_MOUSE MED12_MOUSE CVGHHDPD---------------------------------RVNDIAILCAELTGYCKSL B4DYQ3_HUMAN B4DYQ3_HUMAN CVGHHDPD---------------------------------RVNDIAILCAELTGYCKSL MED12_PANTR MED12_PANTR CVGHHDPD---------------------------------RVNDIAILCAELTGYCKSL Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN CVGHHDPD---------------------------------RVNDIAILCAELTGYCKSL MED12_HUMAN MED12_HUMAN CVGHHDPD---------------------------------RVNDIAILCAELTGYCKSL MED12_PONPY MED12_PONPY CVGHHDPD---------------------------------RVNDIAILCAELTGYCKSL MED12_DANRE MED12_DANRE CVDHRDPE---------------------------------RVNDIGILCAELTAYCRSL Q4RTF3_TETNG Q4RTF3_TETNG CVDHRDPERWVTLLLCDVCLTVCCSSLLSARPQLHVMCRPIRVSDIGILCAELTAYCRYL MATCH *:.*:*. *:.**. :.:***. * * CONSENSUS C?GH?D???????????????????????????????????R?NDIA????ELT??C??L

MD12L_MOUSE MD12L_MOUSE SSEWLGVLKALCCSSNH-VWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQ B7ZMI1_HUMAN B7ZMI1_HUMAN SSEWLGVLKALCCSSNH-VWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQ MD12L_HUMAN MD12L_HUMAN SSEWLGVLKALCCSSNH-VWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQ A2AGH8_MOUSE A2AGH8_MOUSE SAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIR A2AGH9_MOUSE A2AGH9_MOUSE SAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIR MED12_MOUSE MED12_MOUSE SAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIR B4DYQ3_HUMAN B4DYQ3_HUMAN SAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIR MED12_PANTR MED12_PANTR SAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIR Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN SAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIR MED12_HUMAN MED12_HUMAN SAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIR MED12_PONPY MED12_PONPY SAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIR MED12_DANRE MED12_DANRE SAEWLGVLKALCCSSNNGNCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLVR Q4RTF3_TETNG Q4RTF3_TETNG SAEWLGILKALCCSSNNGNCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLVR MATCH *:****:*********: ****:**.***************:********: ***::: CONSENSUS S?EWLGVLKALCCSSN????GFND?LC?VDVSDLSFHDSLATF?AILIARQC??LED???

MD12L_MOUSE MD12L_MOUSE HVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFFPQGTGKP---FPGIRSSCDR B7ZMI1_HUMAN B7ZMI1_HUMAN HVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKP---FPGIRSSCDR MD12L_HUMAN MD12L_HUMAN HVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKP---FPGIRSSCDR A2AGH8_MOUSE A2AGH8_MOUSE CAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKP---TVGIRSSCDR A2AGH9_MOUSE A2AGH9_MOUSE CAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKP---TVGIRSSCDR MED12_MOUSE MED12_MOUSE CAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKP---TVGIRSSCDR B4DYQ3_HUMAN B4DYQ3_HUMAN CAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKP---TVGIRSSCDR MED12_PANTR MED12_PANTR CAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKP---TVGIRSSCDR Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN CAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKP---TVGIRSSCDR MED12_HUMAN MED12_HUMAN CAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKP---TVGIRSSCDR MED12_PONPY MED12_PONPY CAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKP---TVGIRSSCDR MED12_DANRE MED12_DANRE CVAIPSLLNAACSEQDSEPGARLTCRILLHLFRTPQRNPCPQDGTKSDKSIVGIRSSCDR Q4RTF3_TETNG Q4RTF3_TETNG CVAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQRNPVPQDGVK----SVGIRSSCDR MATCH .*:**** ***.: *:*****:***:*****::** . * ******** CONSENSUS ??A?PSLL?AAC???D?EPGAR?TCR?LLHLF??PQ?????????KP?????GIRSSCDR

MD12L_MOUSE MD12L_MOUSE HLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGSNNVNTMKNEDFGMRGLRRDGNAEDAWAT B7ZMI1_HUMAN B7ZMI1_HUMAN HLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLQCDGNADDIWTA MD12L_HUMAN MD12L_HUMAN HLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTA A2AGH8_MOUSE A2AGH8_MOUSE HLLAASQNRIVDGAVFAVLKAVFVLGDAE--------LKGSGFTVPGGTEELPEEEGGGG A2AGH9_MOUSE A2AGH9_MOUSE HLLAASQNRIVDGAVFAVLKAVFVLGDAE--------LKGSGFTVPGGTEELPEEEGGGG MED12_MOUSE MED12_MOUSE HLLAASQNRIVDGAVFAVLKAVFVLGDAE--------LKGSGFTVPGGTEELPEEEGGGG B4DYQ3_HUMAN B4DYQ3_HUMAN HLLAASQNRIVDGAVFAVLKAVFVLGDAE--------LKGSGFTVTGGTEELPEEEGGGG MED12_PANTR MED12_PANTR HLLAASQNRIVDGAVFAVLKAVFVLGDAE--------LKGSGFTVTGGTEELPEEEGGGG Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN HLLAASQNRIVDGAVFAVLKAVFVLGDAE--------LKGSGFTVTGGTEELPEEEGGGG MED12_HUMAN MED12_HUMAN HLLAASQNRIVDGAVFAVLKAVFVLGDAE--------LKGSGFTVTGGTEELPEEEGGGG MED12_PONPY MED12_PONPY HLLAASQNRIVDGAVFAVLKAVFVLGDAE--------LKGSGFTVTGGTEELPEEEGGGG MED12_DANRE MED12_DANRE HLLAASQNSIVVGAVFAVLKAVFMLGDAE--------LKGSGFSHPAGLDDIGEDDMGS- Q4RTF3_TETNG Q4RTF3_TETNG HLLAASQNSIVVGAVFAVLKAVFMLGDAE--------LRGSGLSHTSGLDDISE------ MATCH *****::* * *********:::****: ::...: . : CONSENSUS HLLAA??N?I??GAVFAVLKA???LGDA?????????LK???F???G?????????????

MD12L_MOUSE MD12L_MOUSE SQNSKSYGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSN B7ZMI1_HUMAN B7ZMI1_HUMAN SQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSN MD12L_HUMAN MD12L_HUMAN SQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSN A2AGH8_MOUSE A2AGH8_MOUSE SSGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKS---LCEDSNDLQDPVLSS A2AGH9_MOUSE A2AGH9_MOUSE SSGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKS---LCEDSNDLQDPVLSS MED12_MOUSE MED12_MOUSE SSGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKS---LCEDSNDLQDPVLSS B4DYQ3_HUMAN B4DYQ3_HUMAN SGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKS---LCEDSNDLQDPVLSS MED12_PANTR MED12_PANTR SGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKS---LCEDSNDLQDPVLSS Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN SGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKS---LCEDSNDLQDPVLSS MED12_HUMAN MED12_HUMAN SGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKS---LCEDSNDLQDPVLSS MED12_PONPY MED12_PONPY SGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKS---LCEDSNDLQDPVLSS MED12_DANRE MED12_DANRE ---KKSGGRNVSIETASLVVYAKYVLKSICHQEWVGERCLKS---LSEDSSALQDPVLVN Q4RTF3_TETNG Q4RTF3_TETNG -------GGNVSIETASLDVYAKYVLKTICQQEWVGERCLKS---LSEDSSALQDPVLVN MATCH * .:*:***.* **:***::**:******:***. *. *.. : **** . CONSENSUS S??????G??IS?ETA?L??YA?YVLR?ICQQEWVGE?CLK????LC?D?????DPVLS?

MD12L_MOUSE MD12L_MOUSE MQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDP B7ZMI1_HUMAN B7ZMI1_HUMAN MQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDP MD12L_HUMAN MD12L_HUMAN MQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDP A2AGH8_MOUSE A2AGH8_MOUSE AQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILKNLDQWTMRQSSLELQLMIKQTPNT- A2AGH9_MOUSE A2AGH9_MOUSE AQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILKNLDQWTMRQSSLELQLMIKQTPNT- MED12_MOUSE MED12_MOUSE AQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILKNLDQWTMRQSSLELQLMIKQTPNT- B4DYQ3_HUMAN B4DYQ3_HUMAN AQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNN- MED12_PANTR MED12_PANTR AQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNN- Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN AQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNN- MED12_HUMAN MED12_HUMAN AQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNN- MED12_PONPY MED12_PONPY AQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNN- MED12_DANRE MED12_DANRE IQAQRLLQLICYPHRQLDSEEGDNPQRQRIKRILQNMDQWTMRQSSLELQLMIKQSSNN- Q4RTF3_TETNG Q4RTF3_TETNG IQAQRLLQLICYPHRQLDSDDGDNPQRQRIKRILQ------------------------- MATCH ***:*:******* : :*:* ***:*****: CONSENSUS ?QAQ?L?QLICYPH???????G?N?QRQ?IKRIL?NL?QWT?RQS?LELQLMIKQ?????

MD12L_MOUSE MD12L_MOUSE SSGSVAEMNNLLDNIAKATIEVFQQSADLNNNASNSGMSLFNPNTIGSVDPSSTRQNGIK B7ZMI1_HUMAN B7ZMI1_HUMAN GSGSVAEMNNLLDNIAKATIEVFQQSADLNNS-SNSGMSLFNPNSIGSADTSSTRQNGIK MD12L_HUMAN MD12L_HUMAN GSGSVAEMNNLLDNIAKATIEVFQQSADLNNS-SNSGMSLFNPNSIGSADTSSTRQNGIK A2AGH8_MOUSE A2AGH8_MOUSE ------EMNSLLENIAKATIEVFQQSAETGSS----------SGSTASNMPSSSK---TK A2AGH9_MOUSE A2AGH9_MOUSE ------EMNSLLENIAKATIEVFQQSAETGSS----------SGSTASNMPSSSK---TK MED12_MOUSE MED12_MOUSE ------EMNSLLENIAKATIEVFQQSAETGSS----------SGSTASNMPSSSK---TK B4DYQ3_HUMAN B4DYQ3_HUMAN ------EMNSLLENIAKATIEVFQQSAETGSS----------SGSTASNMPSSSK---TK MED12_PANTR MED12_PANTR ------EMNSLLENIAKATIEVFQQSAETGSS----------SGSTASNMPSSSK---TK Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN ------EMNSLLENIAKATIEVFQQSAETGSS----------SGSTASNMPSSSK---TK MED12_HUMAN MED12_HUMAN ------EMNSLLENIAKATIEVFQQSAETGSS----------SGSTASNMPSSSK---TK MED12_PONPY MED12_PONPY ------EMNSLLENIAKATIEVFQQSAETGSS----------SGSTASNMPSSSK---TK MED12_DANRE MED12_DANRE ------ELYSLLENIAKATIEVFQKSAEMNSSNPSWNGSAV-SGSSVSNSNSASK---LK Q4RTF3_TETNG Q4RTF3_TETNG ------ELYSLLENIAKATIEVFQKSAEMNSSNPSGNGAVGSGGSTSNNNSTASK---MK MATCH *: .**:***********:**: ... .: . :::: * CONSENSUS ??????EMN?LL?NIAKATIEVFQQSA????S????????????S??S???SS??????K

MD12L_MOUSE MD12L_MOUSE TFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMS B7ZMI1_HUMAN B7ZMI1_HUMAN TFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMS MD12L_HUMAN MD12L_HUMAN TFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMS A2AGH8_MOUSE A2AGH8_MOUSE PVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMS A2AGH9_MOUSE A2AGH9_MOUSE PVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMS MED12_MOUSE MED12_MOUSE PVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMS B4DYQ3_HUMAN B4DYQ3_HUMAN PVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMS MED12_PANTR MED12_PANTR PVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMS Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN PVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMS MED12_HUMAN MED12_HUMAN PVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMS MED12_PONPY MED12_PONPY PVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMS MED12_DANRE MED12_DANRE PVLSSSERSGVWLVAPLIGKLPTSVQGHVLKAAGEELEKGQHLGPSSRKERDRQKQKSMS Q4RTF3_TETNG Q4RTF3_TETNG PILSSSERSGVWLVAPLIAKLSTAVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMS MATCH ..*** ** *********.:*.*:***:****************.**:************ CONSENSUS ??LSS?ER?GVWLVAPLIA?LPTSVQG?VLKAAGEELEKGQHLGSSS?KERDRQKQKSMS

MD12L_MOUSE MD12L_MOUSE LLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDTKARQMMHEALQ B7ZMI1_HUMAN B7ZMI1_HUMAN LLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQ MD12L_HUMAN MD12L_HUMAN LLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQ A2AGH8_MOUSE A2AGH8_MOUSE LLSQQPFLSLVLTCLKGQDEQREGLLASLHSQVHQIVINWRENQYLDDCKPKQLMHEALK A2AGH9_MOUSE A2AGH9_MOUSE LLSQQPFLSLVLTCLKGQDEQREGLLASLHSQVHQIVINWRENQYLDDCKPKQLMHEALK MED12_MOUSE MED12_MOUSE LLSQQPFLSLVLTCLKGQDEQREGLLASLHSQVHQIVINWRENQYLDDCKPKQLMHEALK B4DYQ3_HUMAN B4DYQ3_HUMAN LLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQMHQIVNNWRDDQYLDDCKPKQLMHEALK MED12_PANTR MED12_PANTR LLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALK Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN LLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALK MED12_HUMAN MED12_HUMAN LLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALK MED12_PONPY MED12_PONPY LLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALK MED12_DANRE MED12_DANRE LLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQMMHEALK Q4RTF3_TETNG Q4RTF3_TETNG LLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQLQQIVTNWREDQYQDDCKAKQMMHEALK MATCH **************************:** .*::**: ***:::* ** *.:*:*****: CONSENSUS LLSQQPFLSLVLTCLKGQDEQREGLL?SL??QV?QI??NWR???Y?DD?K??Q?MHEAL?

MD12L_MOUSE MD12L_MOUSE LRLNLVGGMFDTVQRSTQGTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTL B7ZMI1_HUMAN B7ZMI1_HUMAN LRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTL MD12L_HUMAN MD12L_HUMAN LRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTL A2AGH8_MOUSE A2AGH8_MOUSE LRLNLVGGMFDTVQRSTQQTTEWAQLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTL A2AGH9_MOUSE A2AGH9_MOUSE LRLNLVGGMFDTVQRSTQQTTEWAQLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTL MED12_MOUSE MED12_MOUSE LRLNLVGGMFDTVQRSTQQTTEWAQLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTL B4DYQ3_HUMAN B4DYQ3_HUMAN LRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTL MED12_PANTR MED12_PANTR LRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTL Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN LRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTL MED12_HUMAN MED12_HUMAN LRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTL MED12_PONPY MED12_PONPY LRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTL MED12_DANRE MED12_DANRE LRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTL Q4RTF3_TETNG Q4RTF3_TETNG LRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTL MATCH ****************** **:** ***:** ******::************.******* CONSENSUS LRLNLVGGMFDTVQRSTQ?TT?WA?LLL?II?SGTVDM??NNELFTTVLDML?VLINGTL

MD12L_MOUSE MD12L_MOUSE ASDLSSASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPM B7ZMI1_HUMAN B7ZMI1_HUMAN ASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPM MD12L_HUMAN MD12L_HUMAN ASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPM A2AGH8_MOUSE A2AGH8_MOUSE AADMSSISQGSMEENKRAYMNLVKKLQKDLGERQSDSLEKVHQLLPLPKQNRDVITCEPQ A2AGH9_MOUSE A2AGH9_MOUSE AADMSSISQGSMEENKRAYMNLVKKLQKDLGERQSDSLEKVHQLLPLPKQNRDVITCEPQ MED12_MOUSE MED12_MOUSE AADMSSISQGSMEENKRAYMNLVKKLQKDLGERQSDSLEKVHQLLPLPKQNRDVITCEPQ B4DYQ3_HUMAN B4DYQ3_HUMAN AADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQ MED12_PANTR MED12_PANTR AADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQ Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN AADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQ MED12_HUMAN MED12_HUMAN AADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQ MED12_PONPY MED12_PONPY AADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQ MED12_DANRE MED12_DANRE AADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQ Q4RTF3_TETNG Q4RTF3_TETNG AADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQ MATCH *:*:*. * *. **********.***:*:**:::*:*::**:********. ******* CONSENSUS A?D?SS?S?G??EENKRAYMNL?KKL?K?LG???S?S??KV?QLLPLPKQ??DVITCEP?

MD12L_MOUSE MD12L_MOUSE GSLIDTKGNKIAGFDSIDKKQARGLQVSTKQKVSPWDLFEGQKNPA-PLSWAWFGTVRVD B7ZMI1_HUMAN B7ZMI1_HUMAN GSLIDTKGNKIAGFDSIDKKQ--GLQVSTKQKVSPWDLFEGQKNPA-PLSWAWFGTVRVD MD12L_HUMAN MD12L_HUMAN GSLIDTKGNKIAGFDSIDKKQ--GLQVSTKQKVSPWDLFEGQKNPA-PLSWAWFGTVRVD A2AGH8_MOUSE A2AGH8_MOUSE GSLIDTKGNKIAGFDSIFKKE--GLQVSTKQKISPWELFEGLKPSTAPLSWAWFGTVRVD A2AGH9_MOUSE A2AGH9_MOUSE GSLIDTKGNKIAGFDSIFKKE--GLQVSTKQKISPWELFEGLKPSTAPLSWAWFGTVRVD MED12_MOUSE MED12_MOUSE GSLIDTKGNKIAGFDSIFKKE--GLQVSTKQKISPWELFEGLKPSTAPLSWAWFGTVRVD B4DYQ3_HUMAN B4DYQ3_HUMAN GSLIDTKGNKIAGFDSIFKKE--GLQVSTKQKISPWDLFEGLKPSA-PLSWGWFGTVRVD MED12_PANTR MED12_PANTR GSLIDTKGNKIAGFDSIFKKE--GLQVSTKQKISPWDLFEGLKPSA-PLSWGWFGTVRVD Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN GSLIDTKGNKIAGFDSIFKKE--GLQVSTKQKISPWDLFEGLKPSA-PLSWGWFGTVRVD MED12_HUMAN MED12_HUMAN GSLIDTKGNKIAGFDSIFKKE--GLQVSTKQKISPWDLFEGLKPSA-PLSWGWFGTVRVD MED12_PONPY MED12_PONPY GSLIDTKGNKIAGFDSIFKKE--GLQVSTKQKISPWDLFEGLKPSA-PLSWGWFGTVRVD MED12_DANRE MED12_DANRE GSLIDTKGNKIAGFE----KE--GLQVSTKQKISPWDVFEGLKHSA-PLSWGWFGTIRVD Q4RTF3_TETNG Q4RTF3_TETNG GSLIDTKGNKIAGFE----KE--GLQVSTKQKISPWDVFEGLKHSA-PLSWGWFGTIRVD MATCH **************: *: *********:***::*** * .: ****.****:*** CONSENSUS GSLIDTKGNKIAGFDSI?KK???GLQVSTKQK?SPW?LFEG?K????PLSW?WFGTVRVD

MD12L_MOUSE MD12L_MOUSE RKVIKYEEQQHFLLYHTHTMPKPRSYYLEPLPLPPEEEEEELTSPVSQEPERKSAELSDQ B7ZMI1_HUMAN B7ZMI1_HUMAN RRVIKYEEQHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQ MD12L_HUMAN MD12L_HUMAN RRVIKYEEQHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQ A2AGH8_MOUSE A2AGH8_MOUSE RRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPP--EDEEPPAPALLEPEKKAPEPPKT A2AGH9_MOUSE A2AGH9_MOUSE RRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPP--EDEEPPAPALLEPEKKAPEPPKT MED12_MOUSE MED12_MOUSE RRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPP--EDEEPPAPALLEPEKKAPEPPKT B4DYQ3_HUMAN B4DYQ3_HUMAN RRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPP--EDEEPPAPTLLEPEKKAPEPPKT MED12_PANTR MED12_PANTR RRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPP--EDEEPPAPTLLEPEKKAPEPPKT Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN RRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPP--EDEEPPAPTLLEPEKKAPEPPKT MED12_HUMAN MED12_HUMAN RRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPP--EDEEPPAPTLLEPEKKAPEPPKT MED12_PONPY MED12_PONPY RRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPP--EDEEPPAPTLLEPEKKAPEPPKT MED12_DANRE MED12_DANRE RKVTKFEEQQRLLLYHTHIKPKQRSYYLAPLNLPQ--EEEEPLTPVPPEPDKKL-DTAKV Q4RTF3_TETNG Q4RTF3_TETNG RKVNKFEEQQRFLLYHTHLKPKPRSYYLEPLPLPP--EEEEPLTPMSQEPEKKMMEAVKP MATCH *:* : ***:::****** *: *:*** ** ** *:** :* **::* : . CONSENSUS R?V???EEQQ?LLLYHTH??P?PR?YYL?PLPLPP??E?EEP??P???EPE?K??E????

MD12L_MOUSE MD12L_MOUSE GKATADEEKKTKGRKRKTKSSSRI-DEYQQTNLYRVPPNYS--PMS----SQMTHHPQPA B7ZMI1_HUMAN B7ZMI1_HUMAN GKTTTDEEKKTKGRKRKTKSSSRV-DEYPQSNIYRVPPNYS--PIS----SQMMHHPQST MD12L_HUMAN MD12L_HUMAN GKTTTDEEKKTKGRKRKTKSSSRV-DEYPQSNIYRVPPNYS--PIS----SQMMHHPQST A2AGH8_MOUSE A2AGH8_MOUSE DKPGAAPPSTEERKKKSTKGKKRS-QPATKNEDYGMGPGRSG-PYGVTVPPDLLHHANPG A2AGH9_MOUSE A2AGH9_MOUSE DKPGAAPPSTEERKKKSTKGKKRS-QPATKNEDYGMGPGRSG-PYGVTVPPDLLHHANPG MED12_MOUSE MED12_MOUSE DKPGAAPPSTEERKKKSTKGKKRS-QPATKNEDYGMGPGRSG-PYGVTVPPDLLHHANPG B4DYQ3_HUMAN B4DYQ3_HUMAN DKPGAAPPSTEERKKKSTKGKKRS-QPATKTEDYGMGPGRSG-PYGVTVPPDLLHHPNPG MED12_PANTR MED12_PANTR DKPGAAPPSTEERKKKSTKGKKRS-QPATKTEDYGMGPGRSG-PYGVTVPPDLLHHPNPG Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN DKPGAAPPSTEERKKKSTKGKKRS-QPATKTEDYGMGPGRSG-PYGVTVPPDLLHHPNPG MED12_HUMAN MED12_HUMAN DKPGAAPPSTEERKKKSTKGKKRS-QPATKTEDYGMGPGRSG-PYGVTVPPDLLHHPNPG MED12_PONPY MED12_PONPY DKPGAAPPSTEERKKKSTKGKKRS-QPATKTEDYGMGPGRSG-PYGVTVPPDLLHHPNPG MED12_DANRE MED12_DANRE EKSVSNVPTKKKKKKPASTVKQEDYKPHNTVMQYAPGMTPD-------LPLSMGQTNMSY Q4RTF3_TETNG Q4RTF3_TETNG EKSVPGVPSDSNKKKPS---KKKK-NSSNKTED-GVNRAPGGVSYGTNMPPELMQNHPYG MATCH *. . . : :* ... . . .: : CONSENSUS ?K????????????K??TK???R??????????Y???P??S??P??????????HH????

MD12L_MOUSE MD12L_MOUSE ---LWGYNLVSQPQQPSFFLQNPSLNPGGSRLDPAGSFVPTNTKQALSNMLQRRSG--AM B7ZMI1_HUMAN B7ZMI1_HUMAN ---LWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSG--AM MD12L_HUMAN MD12L_HUMAN ---LWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSG--AM A2AGH8_MOUSE A2AGH8_MOUSE SISHLSY----RQSSMGLYTQNQPLPAGGPRVDP---YRPVRLP-MQK-LPTRPTY--PG A2AGH9_MOUSE A2AGH9_MOUSE SISHLSY----RQSSMGLYTQNQPLPAGGPRVDP---YRPVRLP-MQK-LPTRPTY--PG MED12_MOUSE MED12_MOUSE SISHLSY----RQSSMGLYTQNQPLPAGGPRVDP---YRPVRLP-MQK-LPTRPTY--PG B4DYQ3_HUMAN B4DYQ3_HUMAN SITHLNY----RQGSIGLYTQNQPLPAGGPRVDP---YRPVRLP-MQK-LPTRPTY--PG MED12_PANTR MED12_PANTR SITHLNY----RQGSIGLYTQNQPLPAGGPRVDP---YRPVRLP-MQK-LPTRPTY--PG Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN SITHLNY----RQGSIGLYTQNQPLPAGGPRVDP---YRPVRLP-MQK-LPTRPTY--PG MED12_HUMAN MED12_HUMAN SITHLNY----RQGSIGLYTQNQPLPAGGPRVDP---YRPVRLP-MQK-LPTRPTY--PG MED12_PONPY MED12_PONPY SITHLNY----RQGSIGLYTQNQPLPAGGPRVDP---YRPVRLP-MQK-LPTRPTY--PG MED12_DANRE MED12_DANRE ---RMGY-----QAPMNMYAQNQPLPPGGPGLEP--PFRP-RVP-MNK-MPPRPNYTMPN Q4RTF3_TETNG Q4RTF3_TETNG ---RLPY----GQQAMNMYTQNQPLPPGGPGLEP--PYRPARNPQMNKMMPVRPNY--TS MATCH * .:: ** .* .**. ::* : * . . : * . . CONSENSUS ??????Y?????????????QNQ?L??GG?R?DP?????P????????????R???????

MD12L_MOUSE MD12L_MOUSE LQP---PSLHAVTSQQ-QLLQMKLLQQQQQQQQQQQQQQQRLLRQAQTRPFQQGQPGDQA B7ZMI1_HUMAN B7ZMI1_HUMAN MQP---PSLHAITSQQ-QLIQMKLLQQ---------QQQQRLLRQAQ------------- MD12L_HUMAN MD12L_HUMAN MQP---PSLHAITSQQ-QLIQMKLLQQ---------QQQQRLLRQAQTRPFQQGQPGDQA A2AGH8_MOUSE A2AGH8_MOUSE VLP---TTMSTVMGLEPSSYKTSVYRQQQPTV----PQGQRLRQQLQAKIQSQGMLGQ-- A2AGH9_MOUSE A2AGH9_MOUSE VLP---TTMSTVMGLEPSSYKTSVYRQQQPTV----PQGQRLRQQLQAKIQSQGMLGQ-- MED12_MOUSE MED12_MOUSE VLP---TTMSTVMGLEPSSYKTSVYRQQQPTV----PQGQRLRQQLQAKIQSQGMLGQ-- B4DYQ3_HUMAN B4DYQ3_HUMAN VLP---TTMTGVMGLEPSSYKTSVYRQQQPAV----PQGQRLRQQLQ---QSQGMLGQ-- MED12_PANTR MED12_PANTR VLP---TTMTGVMGLEPSSYKTSVYRQQQPAV----PQGQRLRQQLQAKIQSQGMLGQ-- Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN VLP---TTMTGVMGLEPSSYKTSVYRQQQPAV----PQGQRLRQQLQAKIQSQGMLGQ-- MED12_HUMAN MED12_HUMAN VLP---TTMTGVMGLEPSSYKTSVYRQQQPAV----PQGQRLRQQLQ---QSQGMLGQ-- MED12_PONPY MED12_PONPY VLP---TTMTGVMGLEPSSYKTSVYRQQQPAV----PQGQRLRQQLQAKIQSQGMLGQ-- MED12_DANRE MED12_DANRE MQT---AGMGNLMGME-KQYQMNY--KPMPNM----AQGQMLRHQLQ---GHNHLIGQ-- Q4RTF3_TETNG Q4RTF3_TETNG MMSGMQGNMPGIMGLD-KQYPMGF--KPQPNM----PQGQ-IRQQLQ--VQNQSLIGQ-- MATCH : . : : . : . : * * : :* * CONSENSUS ??P???????????????????????Q??????????Q?QRL??Q?Q?????Q???G???

MD12L_MOUSE MD12L_MOUSE ALFTAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQAAQQQPGGVVLSPSYNSRAY B7ZMI1_HUMAN B7ZMI1_HUMAN ------------------------------------------------------------ MD12L_HUMAN MD12L_HUMAN ALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSVVLSPSYNSRAY A2AGH8_MOUSE A2AGH8_MOUSE ----SSVHQMTPSSSY-GLQTS----QGYTSYVSHVGLQQ--HTGPA------------- A2AGH9_MOUSE A2AGH9_MOUSE ----SSVHQMTPSSSY-GLQTS----QGYTSYVSHVGLQQ--HTGPAGTMVPPSYSSQPY MED12_MOUSE MED12_MOUSE ----SSVHQMTPSSSY-GLQTS----QGYTSYVSHVGLQQ--HTGPAGTMVPPSYSSQPY B4DYQ3_HUMAN B4DYQ3_HUMAN ----SSVHQMTPSSSY-GLQTS----QGYTPYVSHVGLQQ--HTGPA------------- MED12_PANTR MED12_PANTR ----SSVHQMTPSSSY-GLQTS----QGYTPYVSHVGLQQ--HTGPAGTMVPPSYSSQPY Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN ----SSVHQMTPSSSY-GLQTS----QGYTPYVSHVGLQQ--HTGPAGTMVPPSYSSQPY MED12_HUMAN MED12_HUMAN ----SSVHQMTPSSSY-GLQTS----QGYTPYVSHVGLQQ--HTGPAGTMVPPSYSSQPY MED12_PONPY MED12_PONPY ----SSVHQMTPSSSY-GLQTS----QGYTPYVSHVGLQQ--HTGPAGTMVPPSYSSQPY MED12_DANRE MED12_DANRE -----QIRQVTPNPQYSSMQPAQNIPQGYTSYGSHMGMQP--HPSQTPGMVPNSYGNQGF Q4RTF3_TETNG Q4RTF3_TETNG -----QIRQMTPNQPYTPMQAS----QGYTTFGSHMGMQQ--HLSQGGGMAPSSYGSQNF MATCH CONSENSUS ???????????????Y???Q??????QGYT?Y??????QQ????????????????????

MD12L_MOUSE MD12L_MOUSE PAAH--SSPALMERLRQLQQQPSGYVQQQAS-PYLQPVAGSQRLNHQALQQSPLVG--GG B7ZMI1_HUMAN B7ZMI1_HUMAN --------------TRPFQQ---------------------------------------- MD12L_HUMAN MD12L_HUMAN PAAH--SNPVLMERLRQIQQQPSGYVQQQAS-PYLQPLTGSQRLNHQALQQSPLVG--GG A2AGH8_MOUSE A2AGH8_MOUSE ------------DPTRHLQQRPSGYVHQQAP-TYGHGLTSTQRFSHQTLQQTPMMG--TM A2AGH9_MOUSE A2AGH9_MOUSE QSTHPSTNPTLVDPTRHLQQRPSGYVHQQAP-TYGHGLTSTQRFSHQTLQQTPMMG--TM MED12_MOUSE MED12_MOUSE QSTHPSTNPTLVDPTRHLQQRPSGYVHQQAP-TYGHGLTSTQRFSHQTLQQTPMMG--TM B4DYQ3_HUMAN B4DYQ3_HUMAN ------------DPTRHLQQRPSGYVHQQAP-TYGHGLTSTQRF---------------- MED12_PANTR MED12_PANTR QSTHPSTNPTLVDPTRHLQQRPSGYVHQQAP-TYGHGLTSTQRFSHQTLQQTPMIS--TM Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN QSTHPSTNPTLVDPTRHLQQRPSGYVHQQAP-TYGHGLTSTQRFSHQTLQQTPMIS--TM MED12_HUMAN MED12_HUMAN QSTHPSTNPTLVDPTRHLQQRPSGYVHQQAP-TYGHGLTSTQRFSHQTLQQTPMIS--TM MED12_PONPY MED12_PONPY QSTHPSTNPTLVDPTRHLQQRPSGYVHQQAP-TYGHGLTSTQRFSHQTLQQTPMIS--TM MED12_DANRE MED12_DANRE QTGHPATNPTMVDSIRQMQQRP-GYVHQQAPAAYGHTIQSTQRFPHQSMQQTPMMHGLAQ Q4RTF3_TETNG Q4RTF3_TETNG QGTHPANNPAVVDPHRQLQQRPSGYVHQQAP-GYPHNMQNTQRFVFHK------------ MATCH * :** CONSENSUS ???????????????R??QQ?PSGYV?QQA???Y???????QR?????????????????

MD12L_MOUSE MD12L_MOUSE IDAVLTPAHPNLPSVPLPQD---------------------------PMRPRQQQVRQQQ B7ZMI1_HUMAN B7ZMI1_HUMAN ------------------------------------------------------------ MD12L_HUMAN MD12L_HUMAN IDAVLTSAHPNLPSVPLPQD---------------------------PMRPRQPQVRQQQ A2AGH8_MOUSE A2AGH8_MOUSE TPLSAQGVQAGVRSTSILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQ A2AGH9_MOUSE A2AGH9_MOUSE TPLSAQGVQAGVRSTSILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQ MED12_MOUSE MED12_MOUSE TPLSAQGVQAGVRSTSILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQ B4DYQ3_HUMAN B4DYQ3_HUMAN ------------------------------------------------------------ MED12_PANTR MED12_PANTR TPMSAQGVQAGVRSTAILPE-------QQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQ Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN TPMSAQGVQAGVRSTAILPE-------QQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQ MED12_HUMAN MED12_HUMAN TPMSAQGVQAGVRSTAILPE-------QQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQ MED12_PONPY MED12_PONPY TPMSAQGVQAGVRSTAILPE-------QQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQ MED12_DANRE MED12_DANRE SHLGVQGIHPNMRPNQMMEQ---QQQQQQQQQQQQQQQQQVHQQQQHIRQGPVFRPQQQQ Q4RTF3_TETNG Q4RTF3_TETNG -----EGCRFVCRCLSMKDIIHQVSPSAHPTEPHHARSGSHGRTGRPSEHEAQPDAGRAT MATCH CONSENSUS ????????????????????????????????????????????????????????????

MD12L_MOUSE MD12L_MOUSE RLLQVW----------GREMQQPQQAPQPQQPSQTQSQALGLQAMQPQ------------ B7ZMI1_HUMAN B7ZMI1_HUMAN ------------------------------------------------------------ MD12L_HUMAN MD12L_HUMAN RLLQM----------QQPQQPQPQQPPQPQQSSQSQSQTLGLQAMQPQ------------ A2AGH8_MOUSE A2AGH8_MOUSE QQQQML--------RQQQQQQQQQQQQQQQQQQQPHQQQQQAAPPQPQ---------PQS A2AGH9_MOUSE A2AGH9_MOUSE QQQQML--------RQQQQQQQQQQQQQQQQQQQPHQQQQQAAPPQPQ---------PQS MED12_MOUSE MED12_MOUSE QQQQMLRQQQQQQQQQQQQQQQQQQQQQQQQQQQPHQQQQQAAPPQPQ---------PQS B4DYQ3_HUMAN B4DYQ3_HUMAN ------------------------------------------------------------ MED12_PANTR MED12_PANTR QQQILR-QQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQ---------PQS Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN QQQILR-QQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQ---------PQS MED12_HUMAN MED12_HUMAN QQQILR-QQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQ---------PQS MED12_PONPY MED12_PONPY QQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQ---------PQS MED12_DANRE MED12_DANRE QVQQQVQQQVQQQQVQQQQVQQQVQPQQVQQQQVQQQQQQQVSAAQPPAQALGMQALPPQ Q4RTF3_TETNG Q4RTF3_TETNG AATTATATSSTATAAVPQTTSTKTAAAAAAAGPAGSAAAAAAAAAAAA-------TGPTS MATCH CONSENSUS ????????????????????????????????????????????????????????????

MD12L_MOUSE MD12L_MOUSE QPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQP-------QQGVTPCAHPSHF------ B7ZMI1_HUMAN B7ZMI1_HUMAN ---FPRQGLQQTQQQQQTAALVRQLQKQLSSNQP-------QQGVTPYGHPSHF------ MD12L_HUMAN MD12L_HUMAN QPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQP-------QQGVTPYGHPSHF------ A2AGH8_MOUSE A2AGH8_MOUSE QPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQP-------QPSTNIFGRY--------- A2AGH9_MOUSE A2AGH9_MOUSE QPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQP-------QPSTNIFGRY--------- MED12_MOUSE MED12_MOUSE QPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQP-------QPSTNIFGRY--------- B4DYQ3_HUMAN B4DYQ3_HUMAN -------------------------HTRHCSRHP-------------------------- MED12_PANTR MED12_PANTR QPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQP-------QPSTNIFGRY--------- Q7Z3Z5_HUMAN Q7Z3Z5_HUMAN QPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQP-------QPSTNIFGRY--------- MED12_HUMAN MED12_HUMAN QPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQP-------QPSTNIFGRY--------- MED12_PONPY MED12_PONPY QPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQP-------QPSTNIFGRY--------- MED12_DANRE MED12_DANRE QPMFQRQGMQQTQQQQQTAALVRQLQQQLSSTQP-------AQNNSSY--Y--------- Q4RTF3_TETNG Q4RTF3_TETNG AGSSSAAGRTTTTTTTTAAAAAAAAGVGSTATRPGTEPGSGNAAATPTATYVSPTGNAAD MATCH :* CONSENSUS ???F?RQG?QQTQQQQQTAALVRQLQ?QLS??QP??????????????????????????

MD12L_MOUSE MD12L_MOUSE ------------------- B7ZMI1_HUMAN B7ZMI1_HUMAN ------------------- MD12L_HUMAN MD12L_HUMAN ------------------- A2AGH8_MOUSE A2AGH8_MOUSE ------------------- A2AGH9_MOUSE A2AGH9_MOUSE ------------------- MED12_MOUSE MED12_MOUSE ------------------- B4DYQ3_HUMAN B4DYQ3_HUMAN ------------------- MED12_PANTR MED12_PANTR -------------------