Alignment of the gene Family HBG052630 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
B3DJM2_DANRE B3DJM2_DANRE ---MLRPHSPDQFVSSKPAGFRRWTCNVDDFRQQFESDKHWSARRQFILKHIEQYEHENG Q28C35_XENTR Q28C35_XENTR ---MASCVKW---------DNGASRVSLEDFRQFHENDKQWAARSQFMARHLHLYPGPK- B1WBC2_XENLA B1WBC2_XENLA ---MASSGKW---------DNEASRVSLEDFRQYHETDKQWAGRKQFVARHLHLYPGPK- B2GTX3_XENLA B2GTX3_XENLA ASGNSLLFHASLSLAMASCDNEANRVSLEDFRQFHETEKQWAGRRQFLSRHLHLYPGPK- Q5ZHZ7_CHICK Q5ZHZ7_CHICK ---MSPPP-----------PEAVPEEVLEQWRQYSESERHWAVRRRFILRHLHSYPGAA- A2A3V7_MOUSE A2A3V7_MOUSE ------------------------------------------------------------ NKRF_MOUSE NKRF_MOUSE ------------------------------------------------------------ A4FUC4_BOVIN A4FUC4_BOVIN ------------------------------------------------------------ A2I829_HUMAN A2I829_HUMAN ------------------------------------------------------------ A3F768_HUMAN A3F768_HUMAN ------------------------------------------------------------ A3F769_HUMAN A3F769_HUMAN ------------------------------------------------------------ NKRF_HUMAN NKRF_HUMAN ------------------------------------------------------------ Q6NUN2_HUMAN Q6NUN2_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

B3DJM2_DANRE B3DJM2_DANRE LDKLLALSMVWVNHVFLGCRYGSQLMDKVLEMAEGIDLGEMPSYELVPN--AEAKKRPCS Q28C35_XENTR Q28C35_XENTR IDQLIALSVVWSNIVFIGNRYGEKLTEKVHKMAEGIDIGEIPSFELVPG--AKKTKRSEG B1WBC2_XENLA B1WBC2_XENLA TDQLIALSVVWSNIVFIGNRYGEKLTEKVHKMAEGIDIGEMPSFELVPG----AKKTSGG B2GTX3_XENLA B2GTX3_XENLA TDQLIALSVVWSNIVFIGNRYGEKLTEKVHKMAEGIDVGEMPCFELVPG--AKKTKRS-G Q5ZHZ7_CHICK Q5ZHZ7_CHICK IDQLLALSVLWSNHVFMGCRYGSQVMEKVLKMAEGIGIGEMQTFELVPSKKLKRQRSPPD A2A3V7_MOUSE A2A3V7_MOUSE -------------------------MEKILHMAEGIDIGEMPSYDLMLPKPSKGQKRYLS NKRF_MOUSE NKRF_MOUSE -------------------------MEKILHMAEGIDIGEMPSYDLMLPKPSKGQKRYLS A4FUC4_BOVIN A4FUC4_BOVIN -------------------------MEKILQMAEGIDIGEMPSYDLMLSKASKGQKRHLS A2I829_HUMAN A2I829_HUMAN ------------------------------------------------------------ A3F768_HUMAN A3F768_HUMAN -------------------------MEKILQMAEGIDIGEMPSYDLVLSKPSKGQKRHLS A3F769_HUMAN A3F769_HUMAN -------------------------MEKILQMAEGIDIGEMPSYDLVLSKPSKGQKRHLS NKRF_HUMAN NKRF_HUMAN -------------------------MEKILQMAEGIDIGEMPSYDLVLSKPSKGQKRHLS Q6NUN2_HUMAN Q6NUN2_HUMAN -------------------------MEKILQMAEGIDIGEMPSYDLVLSKPSKGQKRHLS MATCH CONSENSUS ??????????????????????????EK???MAEGID?GEMP???L?????????K????

B3DJM2_DANRE B3DJM2_DANRE SDGSEEPMS--KMPVSKFTCRPRFEPVHFVSGESSGSGNGRTDEKENEKTRRRDEVTDAR Q28C35_XENTR Q28C35_XENTR TDAGEQPQ---KKFASRFGPRPRFEPVHFV---VSSTQDETFQERSNCLDSQKQEQQG-S B1WBC2_XENLA B1WBC2_XENLA ADNGEQPP---KKFASRFGPRPRFEPVRFV---VSSTQEDSFQESINGSDSQKQDQQG-D B2GTX3_XENLA B2GTX3_XENLA ANDGEQPQ---KKFASRFGPRPRFEPVHFV---VSSSQQDSFQESNGLDSQKQAQQGD-- Q5ZHZ7_CHICK Q5ZHZ7_CHICK STERKEVPEPPKKVVPKFRVRPRFEPIHFV---ASAEKDGKKEDSLDSQTQETHQEANTN A2A3V7_MOUSE A2A3V7_MOUSE TYDGQNPPK--KQAGSKFHVRARFEPVHFV---ASSSKAERQEDPYGPQTKDVNGRTHFA NKRF_MOUSE NKRF_MOUSE TYDGQNPPK--KQAGSKFHVRARFEPVHFV---ASSSKAERQEDPYGPQTKDVNGRTHFA A4FUC4_BOVIN A4FUC4_BOVIN TCDGQNPPK--KQAGSKFHVRPRFEPVHFV---ASSSKDERQEDPYGPQAKERNEQTHFA A2I829_HUMAN A2I829_HUMAN ------------------------------------------------------------ A3F768_HUMAN A3F768_HUMAN TCDGQNPPK--KQAGSKFHARPRFEPVHFV---ASSSKDEGQEDPYGPQTKEVNEQTHFA A3F769_HUMAN A3F769_HUMAN TCDGQNPPK--KQAGSKFHARPRFEPVHFV---ASSSKDERQEDPYGPQTKEVNEQTHFA NKRF_HUMAN NKRF_HUMAN TCDGQNPPK--KQAGSKFHARPRFEPVHFV---ASSSKDERQEDPYGPQTKEVNEQTHFA Q6NUN2_HUMAN Q6NUN2_HUMAN TCDGQNPPK--KQAGSKFHARPRFEPVHFV---ASSSKDERQEDPYGPQTKEVNEQTHFA MATCH CONSENSUS ??????P????K???S?F??R?RFEPVHFV????S?????????????????????????

B3DJM2_DANRE B3DJM2_DANRE QKEPDHQAYNGNRGRTPPSSSLDKGRYGY---------DSWPEHRSKDVPSGGTSGLGYS Q28C35_XENTR Q28C35_XENTR GLPPDV----------------------FTTTSDTSDPEDCPEADSFHSDVVEDEGR--- B1WBC2_XENLA B1WBC2_XENLA SLPPDV----------------------CTTTSDTSDQEYCSEMDSFHSDAMEDEGR--- B2GTX3_XENLA B2GTX3_XENLA SLPPDV----------------------FTTTSDTSDQEDCPEMDSLNSDTVEEEGR--- Q5ZHZ7_CHICK Q5ZHZ7_CHICK SVTQPA--------------------------------ENCID-SHFENAQGVDTQI--- A2A3V7_MOUSE A2A3V7_MOUSE SMPRNF----------------------Y---------QDYTQ-DSFSIQDGNSQY---- NKRF_MOUSE NKRF_MOUSE SMPRNF----------------------Y---------QDYTQ-DSFSIQDGNSQY---- A4FUC4_BOVIN A4FUC4_BOVIN NMPRDI----------------------Y---------QDYTQ-DSFSIQDGNSQY---- A2I829_HUMAN A2I829_HUMAN -MPRDI----------------------Y---------QDYTQ-DSFSIQDGNSQY---- A3F768_HUMAN A3F768_HUMAN SMPRDI----------------------Y---------QDYTQ-DSFSIQDGNSQY---- A3F769_HUMAN A3F769_HUMAN SMPRDI----------------------Y---------QDYTQ-DSFSIQDGNSQY---- NKRF_HUMAN NKRF_HUMAN SMPRDI----------------------Y---------QDYTQ-DSFSIQDGNSQY---- Q6NUN2_HUMAN Q6NUN2_HUMAN SMPRDI----------------------Y---------QDYTQ-DSFSIQDGNSQY---- MATCH : : CONSENSUS ??P?????????????????????????????????????????DSF?????????????

B3DJM2_DANRE B3DJM2_DANRE SRGSTSNFMGKVQQEYTAK--YEAHNSRQSDSVLHAGRSDGSGRSGTYESGRRGLGFGHQ Q28C35_XENTR Q28C35_XENTR --HDSGNFMSKIEQSYSAK--FNSHCSTTSKEFRHNVLDMWIG-----VNKQGRKGIGFV B1WBC2_XENLA B1WBC2_XENLA --HDSGNFMSKIEQNYSAK--FNSHYSTMSKEFCSNVLDMWKG-----VNRQGRKGIGFV B2GTX3_XENLA B2GTX3_XENLA --HDSGNFMSKIEQSYSAK--FNAHYSTTSKEFCHNVLDMWKG-----VNQQGRKGIGFV Q5ZHZ7_CHICK Q5ZHZ7_CHICK --SNSAGFGFA-SQAATPNKAVNSTDVATS------------------GMLQVSVPPSAV A2A3V7_MOUSE A2A3V7_MOUSE --CNSSGFIFTKDQPVATNMYFDSGNPAPSS-----------------TSQQANCQPAPE NKRF_MOUSE NKRF_MOUSE --CNSSGFIFTKDQPVATNMYFDSGNPAPSS-----------------TSQQANCQPAPE A4FUC4_BOVIN A4FUC4_BOVIN --CDSSGFIFTKDKPVTANMYFDSGNPAPSS-----------------TSQQADSQSPPE A2I829_HUMAN A2I829_HUMAN --CDSSGFILTKDQPVTANMYFDSGNPAPST-----------------TSQQANSQSTPE A3F768_HUMAN A3F768_HUMAN --CDSSGFILTKDQPVTANMYFDSGNPAPST-----------------TSQQANSQSTPE A3F769_HUMAN A3F769_HUMAN --CDSSGFILTKDQPVTANMYFDSGNPAPST-----------------TSQQANSQSTPE NKRF_HUMAN NKRF_HUMAN --CDSSGFILTKDQPVTANMYFDSGNPAPST-----------------TSQQANSQSTPE Q6NUN2_HUMAN Q6NUN2_HUMAN --CDSSGFILTKDQPVTANMYFDSGNPAPST-----------------TSQQANSQSTPE MATCH .:..* .: :.: :: * : CONSENSUS ????S??F?????Q???????F?S?????S?????????????????????Q????????

B3DJM2_DANRE B3DJM2_DANRE ERPTSSKAFSRAYDGPSRGGTGLLPTPSLPASVPTAAV--EEKQRLIVRVASAVAVTLRD Q28C35_XENTR Q28C35_XENTR KPPKMSDKHGKGRGK---------------STLSGRTIHSLDKAAFINQLSAMVVQYMLQ B1WBC2_XENLA B1WBC2_XENLA KPPKMSDKLGKEFGR---------------STLSGRTLHSLDKAAFIKQLSATILQKMSS B2GTX3_XENLA B2GTX3_XENLA KPPKTSDKFGKGIGK---------------STLSGRALYSLDNSAFIKQLSAIVLQEMAS Q5ZHZ7_CHICK Q5ZHZ7_CHICK QSVS--------------------------ETFPPSAI--MLKQSFIEKLSAAVWKNLAN A2A3V7_MOUSE A2A3V7_MOUSE PPPS--------------------------QMYPESLV--AEKQYFIEKLTATIWKNLSN NKRF_MOUSE NKRF_MOUSE PPPS--------------------------QMYPESLV--AEKQYFIEKLTATIWKNLSN A4FUC4_BOVIN A4FUC4_BOVIN PSPS--------------------------QTFPESVV--AEKQYFIEKLTATIWKNLSN A2I829_HUMAN A2I829_HUMAN PSPS--------------------------QTFPESVV--AEKQYFIEKLTATIWKNLSN A3F768_HUMAN A3F768_HUMAN PSPS--------------------------QTFPESVV--AEKQYFIEKLTATIWKNLSN A3F769_HUMAN A3F769_HUMAN PSPS--------------------------QTFPESVV--AEKQYFIEKLTATIWKNLSN NKRF_HUMAN NKRF_HUMAN PSPS--------------------------QTFPESVV--AEKQYFIEKLTATIWKNLSN Q6NUN2_HUMAN Q6NUN2_HUMAN PSPS--------------------------QTFPESVV--AEKQYFIEKLTATIWKNLSN MATCH . . : : :* :::: : : . CONSENSUS ??P???????????????????????????????????????K??FI??L?A????????

B3DJM2_DANRE B3DJM2_DANRE PAFVGGPEGPNYNFILSRSIQACKTNPEYIYVNLRDIPPADLPKNRKVPCDGYACELRCQ Q28C35_XENTR Q28C35_XENTR PTMKTDSKRIKYTFLLTHSIQSCKTNPEYIYAPLKDISPLDLPQNKKLPVDGFACEVRCQ B1WBC2_XENLA B1WBC2_XENLA PK-QVDPERMNYTFMLSCCTQPFKTNPEYIYVPLKEISPLELPKYTQLPVDGFACEVRCQ B2GTX3_XENLA B2GTX3_XENLA PKLSMNSERINYTFILSHSIQSCKTNPEYIYVPFKDISPINRPKNKNLPADGFACEVRCQ Q5ZHZ7_CHICK Q5ZHZ7_CHICK PDANTGTDKINYTYLLTRSIQACKTNPEYIYVPLKEIAPADLPKSKKLLTDGFACEVRCQ A2A3V7_MOUSE A2A3V7_MOUSE PEMTSGSDKINYTYMLTRCIQACKTNPEYIYAPLKEIPPADIPKNKKLLTDGYACEVRCQ NKRF_MOUSE NKRF_MOUSE PEMTSGSDKINYTYMLTRCIQACKTNPEYIYAPLKEIPPADIPKNKKLLTDGYACEVRCQ A4FUC4_BOVIN A4FUC4_BOVIN PEMTSGSDKINYTYMLTRCIQACKTNPEYIYAPLKEIPPADIPKNKKLLTDGYACEVRCQ A2I829_HUMAN A2I829_HUMAN PEMTSGSDKINYTYMLTRCIQACKTNPEYIYAPLKEIPPADIPKNKKLLTDGYACEVRCQ A3F768_HUMAN A3F768_HUMAN PEMTSGSDKINYTYMLTRCIQACKTNPEYIYAPLKEIPPADIPKNKKLLTDGYACEVRCQ A3F769_HUMAN A3F769_HUMAN PEMTSGSDKINYTYMLTRCIQACKTNPEYIYAPLKEIPPADIPKNKKLLTDGYACEVRCQ NKRF_HUMAN NKRF_HUMAN PEMTSGSDKINYTYMLTRCIQACKTNPEYIYAPLKEIPPADIPKNKKLLTDGYACEVRCQ Q6NUN2_HUMAN Q6NUN2_HUMAN PEMTSGSDKINYTYMLTRCIQACKTNPEYIYAPLKEIPPADIPKNKKLLTDGYACEVRCQ MATCH * ... :*.::*: . *. ********. :::*.* : *: :: **:***:*** CONSENSUS P????????INYT??L???IQ?CKTNPEYIY?PLK?I?P?D?PKNKKL??DG?ACEVRCQ

B3DJM2_DANRE B3DJM2_DANRE SVYLATGYSGSKNGARDRASEQAIK-LFMRPVEIRILRRVYKRRYVNDMVVCQVNTPNPS Q28C35_XENTR Q28C35_XENTR DIYLATGYSFSKNGARDRAAEQAVHLLLQRPLEVRKMNRKCGLKVGEDWVACQVDKPLKG B1WBC2_XENLA B1WBC2_XENLA DIYLATGYSGSKNGARERAAEQAVQ-LLQRSIEVRKMNRRFGQTFREEWVACPIDMPEKG B2GTX3_XENLA B2GTX3_XENLA DIYLATGYSGSKNGARDRAAERAVQ-LLQRPLEVRKMKRKFGQTFREEWVACPIDMPVKR Q5ZHZ7_CHICK Q5ZHZ7_CHICK NVYLTTGYAGSKNGSRDRATELAVK-LLQKSVEVRVVQRKFSTFITKTWWCAWQVVSCPD A2A3V7_MOUSE A2A3V7_MOUSE NIYLTTGYAGSKNGSRDRATELAVK-LLQKRIEVRVVRRKFKHIIGEDLVVCQIGMLSYE NKRF_MOUSE NKRF_MOUSE NIYLTTGYAGSKNGSRDRATELAVK-LLQKRIEVRVVRRKFKHIIGEDLVVCQIGMLSYE A4FUC4_BOVIN A4FUC4_BOVIN NIYLTTGYAGSKNGSRDRATELAVK-LLQKRIEVRVIRRKFKHTFGEDLVVCQIGMPSYD A2I829_HUMAN A2I829_HUMAN NIYLTTGYAGSKNGSRDRATELAVK-LLQKRIEVRVVRRKFKHTFGEDLVVCQIGMSSYE A3F768_HUMAN A3F768_HUMAN NIYLTTGYAGSKNGSRDRATELAVK-LLQKRIEVRVVRRKFKHTFGEDLVVCQIGMSSYE A3F769_HUMAN A3F769_HUMAN NIYLTTGYAGSKNGSRDRATELAVK-LLQKRIEVRVVRRKFKHTFGEDLVVCQIGMSSYE NKRF_HUMAN NKRF_HUMAN NIYLTTGYAGSKNGSRDRATELAVK-LLQKRIEVRVVRRKFKHTFGEDLVVCQIGMSSYE Q6NUN2_HUMAN Q6NUN2_HUMAN NIYLTTGYAGSKNGSRDRATELAVK-LLQKRIEVRVVRRKFKHTFGEDLVVCQIGMSSYE MATCH .:**:***: ****:*:**:* *:: *: : :*:* :.* : . CONSENSUS ?IYL?TGY?GSKNG?RDRA?E?AV??LLQ???EVR???RKF?????E??V?C????????

B3DJM2_DANRE B3DJM2_DANRE LPPPLRNPE----DSPPPST---KGQYVPD-------RSKHWTEFVIMENAHDAICILNN Q28C35_XENTR Q28C35_XENTR LPPALKQENGSVGEMLPAGQQG-AVPAKVGL------STKQWTEFIITENACDAIGILNN B1WBC2_XENLA B1WBC2_XENLA LPPALKQEDSSNCEMSPCGQQS-ADPAKVSL------PAKQWTDFILTENACDAIGILNN B2GTX3_XENLA B2GTX3_XENLA LPPALKQENDSVCEMLPCADPA-KGSL----------PTKEWTDFILTENACGAICVLNN Q5ZHZ7_CHICK Q5ZHZ7_CHICK FPPALKPHE----EFVVANRDCVPAQPSTESAKGSTNTSKHWTSFVLTENASDAIGILNN A2A3V7_MOUSE A2A3V7_MOUSE FPPALKPPE----DLVVLGKDA-SGQPIFNS------SAKHWTNFVITENANDAIGILNN NKRF_MOUSE NKRF_MOUSE FPPALKPPE----DLVVLGKDA-SGQPIFNS------SAKHWTNFVITENANDAIGILNN A4FUC4_BOVIN A4FUC4_BOVIN FPPALKPPE----ELVVLAKDA-SGQPIFNA------SAKHWTNFILTENANDAIGILNN A2I829_HUMAN A2I829_HUMAN FPPALKPPE----DLVVLGKDA-SGQPIFNA------SAKHWTNFVITENANDAIGILNN A3F768_HUMAN A3F768_HUMAN FPPALKPPE----DLVVLGKDA-SGQPIFNA------SAKHWTNFVITENANDAIGILNN A3F769_HUMAN A3F769_HUMAN FPPALKPPE----DLVVLGKDA-SGQPIFNA------SAKHWTNFVITENANDAIGILNN NKRF_HUMAN NKRF_HUMAN FPPALKPPE----DLVVLGKDA-SGQPIFNA------SAKHWTNFVITENANDAIGILNN Q6NUN2_HUMAN Q6NUN2_HUMAN FPPALKQPE----DLVVLGKDA-SGQPIFNA------SAKHWTNFVITENANDAIGILNN MATCH :**.*: : : :*.**.*:: *** .** :*** CONSENSUS ?PPALK?????????????????????????????????K?WT?F??TENA?DAIGILNN

B3DJM2_DANRE B3DJM2_DANRE SAAFNRMKVDYTFDPVPNSNLWLCNVYLQGELVAQARGTKKSAKHSAAEEAVKKLRMNQA Q28C35_XENTR Q28C35_XENTR SATINKMTVEYKYTMISSCS-WKCSVFVQGHCVAEGYGNKKNSKHAAAKEAVRILKDLHP B1WBC2_XENLA B1WBC2_XENLA SADVNKMTVEYKYTMMSNTM-WKCSIFVQDHCLAEAYGNKKSSKHEAAKEAVRILKTFQP B2GTX3_XENLA B2GTX3_XENLA SASLNKMTVEYKYIMMSKSV-WKCGVFVQGHCVAEGYGNKKTSKHAAAKEAVRILKNLQP Q5ZHZ7_CHICK Q5ZHZ7_CHICK SASYNKMSVEYKYDYMPNRM-WRCRVYLQDHCLAEGYGTKKTSKHTAADEALKILQKTQS A2A3V7_MOUSE A2A3V7_MOUSE SASFNKMSIEYKYEMMPNRT-WRCRVFLQDHCLAEGYGTKKTSKHAAADEALKVLQKTQP NKRF_MOUSE NKRF_MOUSE SASFNKMSIEYKYEMMPNRT-WRCRVFLQDHCLAEGYGTKKTSKHAAADEALKVLQKTQP A4FUC4_BOVIN A4FUC4_BOVIN SASYNKMSVEYKYEMMPNRT-WRCRVFLQDHCLAEGYGTKKTSKHAAADEALKILQKTQP A2I829_HUMAN A2I829_HUMAN SASFNKMSIEYKYEMMPNRT-WRCRVFLQDHCLAEGYGTKKTSKHAAADEALKILQKTQP A3F768_HUMAN A3F768_HUMAN SASFNKMSIEYKYEMMPNRT-WRCRVFLQDHCLAEGYGTKKTSKHAAADEALKILQKTQP A3F769_HUMAN A3F769_HUMAN SASFNKMSIEYKYEMMPNRT-WRCRVFLQDHCLAEGYGTKKTSKHAAADEALKILQKTQP NKRF_HUMAN NKRF_HUMAN SASFNKMSIEYKYEMMPNRT-WRCRVFLQDHCLAEGYGTKKTSKHAAADEALKILQKTQP Q6NUN2_HUMAN Q6NUN2_HUMAN SASFNKMSIEYKYEMMPNRT-WRCRVFLQDHCLAEGYGTKKTSKHAAADEALKILQKTQP MATCH ** *:*.::*.: :.. * * :::*.. :*:. *.**.:** **.**:: *: :. CONSENSUS SA??NKM??EYKY?MM?N???W?C?VF?Q?HC?AEGYG?KK?SKH?AA?EA???L???QP

B3DJM2_DANRE B3DJM2_DANRE ARQQEQQQQQQQQQQQQQQFSGGNYFSEESAGCYSQQSSSVAQLGELVILENSDNAICII Q28C35_XENTR Q28C35_XENTR DLPK---THCVQ----------------------STNNVPIKELKDIIVYANSINPVCTL B1WBC2_XENLA B1WBC2_XENLA KLQ--KTCEIKD-------------------YVQATNNGPIKELKDIVVYAKSTNPVCTL B2GTX3_XENLA B2GTX3_XENLA DLQK---TTCAQ--------------------TACTVNDPIKELKDVVVYANSTNPVCTM Q5ZHZ7_CHICK Q5ZHZ7_CHICK NLTAIKMTQVQK------------------VGRSSQGSGRKKDLKDLVVYENSDNPVCTL A2A3V7_MOUSE A2A3V7_MOUSE TYPSVKSSQCHS-------------------GSSPKGSGKKKDIKDLVVYENSSNPVCTL NKRF_MOUSE NKRF_MOUSE TYPSVKSSQCHS-------------------GSSPKGSGKKKDIKDLVVYENSSNPVCTL A4FUC4_BOVIN A4FUC4_BOVIN TYPSVKSSQCQA-------------------GSSPRGSGKKKDIKDLVVYENSSNPVCTL A2I829_HUMAN A2I829_HUMAN TYPSVKSSQCHT-------------------GSSPRGSGKKKDIKDLVVYENSSNPVCTL A3F768_HUMAN A3F768_HUMAN TYPSVKSSQCHT-------------------GSSPRGSGKKKDIKDLVVYENSSNPVCTL A3F769_HUMAN A3F769_HUMAN TYPSVKSSQCHT-------------------GSSPRGSGKKKDIKDLVVYENSSNPVCTL NKRF_HUMAN NKRF_HUMAN TYPSVKSSQCHT-------------------GSSPRGSGKKKDIKDLVVYENSSNPVCTL Q6NUN2_HUMAN Q6NUN2_HUMAN TYPSVKSSQCHT-------------------GSSPRGSGKKKDIKDLVVYENSSNPVCTL MATCH . :: :::: :* *.:* : CONSENSUS ?????????????????????????????????????????K??KD?VVY?NS?NPVCTL

B3DJM2_DANRE B3DJM2_DANRE NDTAQFNKVSAEYKFTVLADHSWRCEVYLDGQYVATGLGPKKTVKHIAAEEALATLRRTQ Q28C35_XENTR Q28C35_XENTR NNTAQFNNITVDYVFERVTGDIWKCKVLMEKQFLAEAMGLKKTVKHEAAGAAVNILKQTQ B1WBC2_XENLA B1WBC2_XENLA NDTAQFNNVTVDYVFERLTGDKWKCKVLMDSQFLAEAVGIKKSLKHDVAEAAVRVLKQTQ B2GTX3_XENLA B2GTX3_XENLA NDTAQFNNVTVDYIFERMAGDKWKCKVFMERQFLAEAVGIKKTLKHEAAEAAVSVLKQTQ Q5ZHZ7_CHICK Q5ZHZ7_CHICK NDTAQFNKMTVEYVFERMTGMRWKCKVLLENEFIAEAVGVKKSVKHEAAEEAVKILKKTQ A2A3V7_MOUSE A2A3V7_MOUSE NDTAQFNRMTVEYVYERMTGLRWKCKVILESEVIAEAVGVKKSVKYEAAGEAVKTLKKTQ NKRF_MOUSE NKRF_MOUSE NDTAQFNRMTVEYVYERMTGLRWKCKVILESEVIAEAVGVKKSVKYEAAGEAVKTLKKTQ A4FUC4_BOVIN A4FUC4_BOVIN NDTAQFNRMTVEYVYERMTGLRWKCKVILESEVIAEAVGVKKTVKYEAAGEAVKTLKKTQ A2I829_HUMAN A2I829_HUMAN NDTAQFNRMTVEYVYERMTGLRWKCKVILESEVIAEAVGVKKTVKYEAAGEAVKTLKKTQ A3F768_HUMAN A3F768_HUMAN NDTAQFNRMTVEYVYERMTGLRWKCKVILESEVIAEAVGVKKTVKYEAAGEAVKTLKKTQ A3F769_HUMAN A3F769_HUMAN NDTAQFNRMTVEYVYERMTGLRWKCKVILESEVIAEAVGVKKTVKYEAAGEAVKTLKKTQ NKRF_HUMAN NKRF_HUMAN NDTAQFNRMTVEYVYERMTGLRWKCKVILESEVIAEAVGVKKTVKYEAAGEAVKTLKKTQ Q6NUN2_HUMAN Q6NUN2_HUMAN NDTAQFNRMTVEYVYERMTGLRWKCKVILESEVIAEAVGVKKTVKYEAAGEAVKTLKKTQ MATCH *:*****.::.:* : ::. *:*:* :: : :* .:* **::*: .* *: *::** CONSENSUS NDTAQFN??TV?YV?ER?TG??WKCKV??E????AEAVG?KK?VK?EAA??AV??LK?TQ

B3DJM2_DANRE B3DJM2_DANRE AVVKSNLRKEGHADAISRDQIMCRSGEEAVRQEIKEDNIGNQLLRKMGWTGGGLGREGDG Q28C35_XENTR Q28C35_XENTR PVVVNNPKKGPDEDAISRNQIRGWSSDESFKQQIKEDNIGNQLLRKMGWKGGGLGKEGEG B1WBC2_XENLA B1WBC2_XENLA PVVVNNLNKGTAEDAISRNQISGWSKEESFKQKIKEDNIGNQLLRKMGWKGGGLGKEGGG B2GTX3_XENLA B2GTX3_XENLA PVVVNNLKNGPAEDAISRNHIRVWSSEESAKQEIKEDNIGNQLLRKMGWKGGGLGKEGGG Q5ZHZ7_CHICK Q5ZHZ7_CHICK PTVVNNLKKGTIEDVISRNEIRGRSAEDALKQKIKEDNIGNQILRKMGWTGGGLGKDGEG A2A3V7_MOUSE A2A3V7_MOUSE PTVINNLKKGTVEDVISRNEIQGRSAEEAYKQQIKEDNIGNQLLRKMGWTGGGLGKSGEG NKRF_MOUSE NKRF_MOUSE PTVINNLKKGTVEDVISRNEIQGRSAEEAYKQQIKEDNIGNQLLRKMGWTGGGLGKSGEG A4FUC4_BOVIN A4FUC4_BOVIN PTVINNLKKGAIEDVISRNEIQGRSAEEAYKQQIKEDNIGNQLLRKMGWTGGGLGKSGEG A2I829_HUMAN A2I829_HUMAN PTVINNLKKGAVEDVISRNEIQGRSAEEAYKQQIKEDNIGNQLLRKMGWTGGGLGKSGEG A3F768_HUMAN A3F768_HUMAN PTVINNLKKGAVEDVISRNEIQGRSAEEAYKQQIKEDNIGNQLLRKMGWTGGGLGKSGEG A3F769_HUMAN A3F769_HUMAN PTVINNLKKGAVEDVISRNEIQGRSAEEAYKQQIKEDNIGNQLLRKMGWTGGGLGKSGEG NKRF_HUMAN NKRF_HUMAN PTVINNLKKGAVEDVISRNEIQGRSAEEAYKQQIKEDNIGNQLLRKMGWTGGGLGKSGEG Q6NUN2_HUMAN Q6NUN2_HUMAN PTVINNLKKGAVEDVISRNEIQGRSAEEAYKQQIKEDNIGNQLLRKMGWTGGGLGKSGEG MATCH ..* .* .: *.***:.* * ::: :*:*********:******.*****:.* * CONSENSUS P?V?NNLKKG??ED?ISRN?I?G?S?EE??KQ?IKEDNIGNQLLRKMGW?GGGLGK?G?G

B3DJM2_DANRE B3DJM2_DANRE IAEPIKVKEQFTREGLGMDMDRHGSQLTKRDIEDIIRNYASSERQDDLRFSTELNNEERR Q28C35_XENTR Q28C35_XENTR ISEPISVKEQFSREGLGLTSNS--HTINKRDIEKIIRNYAASYNQDDLTFSKELSNEERK B1WBC2_XENLA B1WBC2_XENLA ISEPISVKEQFSREGLGLTS----NKINKRDIEKIIRNYANSYNQDDLTFAKELSNEERK B2GTX3_XENLA B2GTX3_XENLA ISEPVSVKEQFSREGLGLTT----NKINKRDIEKIIRNYADSYNQDDLTFAKELSNEERK Q5ZHZ7_CHICK Q5ZHZ7_CHICK IREPISVKEQFKREGLGLDVERV-NKIAKRDIEQIIRNYAHSESHVDLTFSTELTNDERK A2A3V7_MOUSE A2A3V7_MOUSE IREPISVKEQHKREGLGLDVERV-NKIAKRDIEQIIRNYARSESHSDLTFSTELTNDERK NKRF_MOUSE NKRF_MOUSE IREPISVKEQHKREGLGLDVERV-NKIAKRDIEQIIRNYARSESHSDLTFSTELTNDERK A4FUC4_BOVIN A4FUC4_BOVIN IREPISVKEQHKREGLGLDVERV-NKIAKRDIEQIIRNYARSESHTDLTFSTELTNDERK A2I829_HUMAN A2I829_HUMAN IREPISVKEQHKREGLGLDVERV-NKIAKRDIEQIIRNYARSESHTDLTFSRELTNDERK A3F768_HUMAN A3F768_HUMAN IREPISVKEQHKREGLGLDVERV-NKIAKRDIEQIIRNYARSESHTDLTFSRELTNDERK A3F769_HUMAN A3F769_HUMAN IREPISVKEQHKREGLGLDVERV-NKIAKRDIEQIIRNYARSESHTDLTFSRELTNDERK NKRF_HUMAN NKRF_HUMAN IREPISVKEQHKREGLGLDVERV-NKIAKRDIEQIIRNYARSESHTDLTFSRELTNDERK Q6NUN2_HUMAN Q6NUN2_HUMAN IREPISVKEQHKREGLGLDVERV-NKIAKRDIEQIIRNYARSESHTDLTFSRELTNDERK MATCH * **:.****..*****: : *****.****** * : ** *: **.*:**: CONSENSUS I?EPISVKEQ??REGLGL??????NKI?KRDIE?IIRNYA?S????DLTFS?EL?N?ERK

B3DJM2_DANRE B3DJM2_DANRE QIHQVSQRYGLRSKSYGQGRQRFLVVSRRVQKEQLIGQLLQEGQVGRYELVKPQPL- Q28C35_XENTR Q28C35_XENTR YIHQISQKYGLKSKSHGHGNERFLVVSRKRNKQDLIHQLIQDGQVGSYALLMPQQKQ B1WBC2_XENLA B1WBC2_XENLA NIHQISQKYGLRSKSHGQGTERFLVVSRKRSKQDLIHQLRQEGQVGSYALLMPQQ-- B2GTX3_XENLA B2GTX3_XENLA YIHQISQKFGLRSKSRGQGTERFLVVSRKRSKQDLIDQLRQDGQVGSYELLMPQQK- Q5ZHZ7_CHICK Q5ZHZ7_CHICK QIHQIAQKYGLKSKSHGQGRDRYLVVSRKRRKEDLLDQLKQEGHVGHYELIMPQAN- A2A3V7_MOUSE A2A3V7_MOUSE QIHQIAQKYGLKSKSHGVGHDRYLVVGRKRRKEDLLDQLKQEGQVGHYELVMPQAN- NKRF_MOUSE NKRF_MOUSE QIHQIAQKYGLKSKSHGVGHDRYLVVGRKRRKEDLLDQLKQEGQVGHYELVVPQAN- A4FUC4_BOVIN A4FUC4_BOVIN QIHQIAQKYGLKSKSHGVGHDRYLVVGRKRRKEDLLDQLKQEGQVGHYELVMPQAN- A2I829_HUMAN A2I829_HUMAN QIHQIAQKYGLKSKSHGVGHDRYLVVGRKRRKEDLLDQLKQEGQVGHYELVMPQAN- A3F768_HUMAN A3F768_HUMAN QIHQIAQKYGLKSKSHGVGHDRYLVVGRKRRKEDLLDQLKQEGQVGHYELVMPQAN- A3F769_HUMAN A3F769_HUMAN QIHQIAQKYGLKSKSHGVGHDRYLVVGRKRRKEDLLDQLKQEGQVGHYELVMPQAN- NKRF_HUMAN NKRF_HUMAN QIHQIAQKYGLKSKSHGVGHDRYLVVGRKRRKEDLLDQLKQEGQVGHYELVMPQAN- Q6NUN2_HUMAN Q6NUN2_HUMAN QIHQIAQKYGLKSKSHGVGHDRYLVVGRKRRKEDLLDQLKQEGQVGHYELVMPQAN- MATCH ***::*::**:*** * * :*:***.*: *::*: ** *:*:** * *: ** CONSENSUS ?IHQI?QKYGL?SKSHG?G??R?LVV?RKR?K?DL??QL?QEGQVG?YEL?MPQ???


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