Alignment of the gene Family HBG052750 of HOVERGEN

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Isoforms are ON
Q6NWE4_DANRE Q6NWE4_DANRE MTLSVSS---------------------------------SSNEKSTNVILLLMEFL--- Q4TA60_TETNG Q4TA60_TETNG MSLTVKAYLLGKDEAVKEVRRFAVDHDVS-----------SSFEYLCRKTAEIFSNLKNS B5X3Q9_SALSA B5X3Q9_SALSA MSMTVKAYLLGKEDAPKEIRRIAVDQDVS-----------TSFEYLKKKVEDVFSTLRNV SQSTM_MOUSE SQSTM_MOUSE ASFTVKAYLLGKEEATREIRRFSFCFSPEPEAEAQAAAGPGPCERLLSRVAVLFPTLRPG SQSTM_RAT SQSTM_RAT ASLTVKAYLLGKEEAAREIRRFSFCFSPEPEAE--AAAGPGPCERLLSRVAVLFPALRPG Q32PJ9_BOVIN Q32PJ9_BOVIN ASLTVKAYLLGKEDAAREIRRFSFCFSPEPEAEAEAAPGPRPCERLLSRVAALFPVLRPG A7E3V0_BOVIN A7E3V0_BOVIN ASLTVKAYLLGKEDAAREIRRFSFCFSPEPEAEAEAAPGPRPCERLLNRVAALFPVLRPG Q13502_HUMAN Q13502_HUMAN -------------------RRFSFCFSPEPEAEAEAAPGPRPCERLLNRVAALFPVLRPG B4E3V2_HUMAN B4E3V2_HUMAN ------------------------------------------------------------ SQSTM_PONAB SQSTM_PONAB ASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPG A6NFN7_HUMAN A6NFN7_HUMAN ------------------------------------------------------------ SQSTM_HUMAN SQSTM_HUMAN ASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPG Q66KM6_XENTR Q66KM6_XENTR MPVTVKAYLLGKDESHREIRRFQLELPAAGKEK----ASVSSCELLANKVTGVFQGLKGG Q6PGS1_XENLA Q6PGS1_XENLA MTVTVKAYLLGKDESHKEIRRFQLELPVAGKGK--AASSGSSCEILANKVTDVFQGLKGG MATCH CONSENSUS ???????????????????????????????????????????E????????????L???

Q6NWE4_DANRE Q6NWE4_DANRE GFRSLHL----TLALLVPVIWVHLQWGLQDHLIWGVLLTTLPLTQW-------------- Q4TA60_TETNG Q4TA60_TETNG AFTMFYKDEDEDLVAFSSDDELMMGLGCMKDATFRIFIKEKKE-HRRDFPLHALPPFGFG B5X3Q9_SALSA B5X3Q9_SALSA TYQMFYKDEDGDMIAFSTDDELIMGLTCIKDYTFRLFIKEKKE-QWREFPAFAFPGGVPP SQSTM_MOUSE SQSTM_MOUSE GFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKE-CRRE------------ SQSTM_RAT SQSTM_RAT GFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKE-CRRE------------ Q32PJ9_BOVIN Q32PJ9_BOVIN GFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKE-CRRD------------ A7E3V0_BOVIN A7E3V0_BOVIN GFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKE-CRRD------------ Q13502_HUMAN Q13502_HUMAN GFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKE-CRRD------------ B4E3V2_HUMAN B4E3V2_HUMAN ------------------------------------MTSSEST-LKRK------------ SQSTM_PONAB SQSTM_PONAB GFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKE-CRRD------------ A6NFN7_HUMAN A6NFN7_HUMAN -----------------------MAMSYVKDDIFRIYIKEKKE-CRRD------------ SQSTM_HUMAN SQSTM_HUMAN GFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKE-CRRD------------ Q66KM6_XENTR Q66KM6_XENTR AFQMFYKDEEGDLVAFSTDEELHMGLSLLNEDVFRIYIKERKE-CKRD------------ Q6PGS1_XENLA Q6PGS1_XENLA AFQMFYKDEEGDLVAFSTDEELHMGLSLLNEDVFRIYIKEKKE-CKRD------------ MATCH . CONSENSUS ???????????????????????M?????????FR??IKE?KE???R?????????????

Q6NWE4_DANRE Q6NWE4_DANRE ------------------------------------------------------------ Q4TA60_TETNG Q4TA60_TETNG -------HPPPPPGAHHTLPPPMVPPQ--------------VLHPSVTCDGCEGPVVGTR B5X3Q9_SALSA B5X3Q9_SALSA FAYPPPPGTPHMGPP--------PPHGHHGHHGHGHHGHGPMVHPNVTCDECEGSVAGTR SQSTM_MOUSE SQSTM_MOUSE -------HRPPCAQE--------APRN--------------MVHPNVICDGCNGPVVGTR SQSTM_RAT SQSTM_RAT -------HRPPCAQE--------A-RS--------------MVHPNVICDGCNGPVVGTR Q32PJ9_BOVIN Q32PJ9_BOVIN -------QRPSCAQE--------VPRN--------------MVHPNVICDGCNGPVVGTR A7E3V0_BOVIN A7E3V0_BOVIN -------QRPSCAQE--------VPRN--------------MVHPNVICDGCNGPVVGTR Q13502_HUMAN Q13502_HUMAN -------QRPSCAQE--------VPRN--------------MVHPNVICDGCNGPVVGTR B4E3V2_HUMAN B4E3V2_HUMAN ------------------------------------------------------------ SQSTM_PONAB SQSTM_PONAB -------HRPPCAQE--------APRN--------------MVHPNVICDGCNGPVVGTR A6NFN7_HUMAN A6NFN7_HUMAN -------HRPPCAQE--------APRN--------------MVHPNVICDGCNGPVVGTR SQSTM_HUMAN SQSTM_HUMAN -------HRPPCAQE--------APRN--------------MVHPNVICDGCNGPVVGTR Q66KM6_XENTR Q66KM6_XENTR -------HRGHCGQE--------TPQN--------------VVHPNVTCDGCDGPVVGNR Q6PGS1_XENLA Q6PGS1_XENLA -------HRGHCGQE--------TQQN--------------VVHPNVTCDGCDGPVVGNR MATCH CONSENSUS ???????????????????????????????????????????HP?V?CD?C?G?V?G?R

Q6NWE4_DANRE Q6NWE4_DANRE --CTVCPDYDLCPTCQSKGLHKEHALLPIFHPMANVFEWLPRGKFWRKMRHC----MW-A Q4TA60_TETNG Q4TA60_TETNG FKCSVCPNYDLCSACQAKGTHTEHPLLPIWHPL----QWFPRGKWMKWMRHC----MWNQ B5X3Q9_SALSA B5X3Q9_SALSA FKCTVCPDYDLCSTCQAKGLHKEHVLLPIWHPFNNAFEWFPRGKWMRKMRHC----TWAQ SQSTM_MOUSE SQSTM_MOUSE YKCSVCPDYDLCSVCEGKGLHREHSKLIFPNPFGHLSDSFSHSRWLRKLKHG--HFGW-P SQSTM_RAT SQSTM_RAT YKCSVCPDYDLCSVCEGKGLHREHSKLIFPNPFGHLSDSFSHSRWLRKLKHG--HFGW-P Q32PJ9_BOVIN Q32PJ9_BOVIN YKCSVCPDYDLCSACEGKGLHREHGKLAFPSPIGHFSEGFSHSRWLRKLKHG--HFGW-P A7E3V0_BOVIN A7E3V0_BOVIN YKCSVCPDYDLCSACEGKGLHQEHGKLAFPSPIGHFSEGFSHSRWLRKLKHG--HFGW-P Q13502_HUMAN Q13502_HUMAN YKCSVCPDYDLCSACEGKGLHREHGKLAFPSPIGHFSEGFSHSRWLRKLKHG--HFGW-P B4E3V2_HUMAN B4E3V2_HUMAN ------------KSAGGTTAHRVLRR----RPFGHLSEGFSHSRWLRKVKHG--HFGW-P SQSTM_PONAB SQSTM_PONAB YKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHG--HFGW-S A6NFN7_HUMAN A6NFN7_HUMAN YKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHG--HFGW-P SQSTM_HUMAN SQSTM_HUMAN YKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHG--HFGW-P Q66KM6_XENTR Q66KM6_XENTR FKCLICPDYDLCSTCEKKGIHKEHNMIMFPTPL-----VYPRSRWFRKMHHGVPPFPWMQ Q6PGS1_XENLA Q6PGS1_XENLA FKCLICPDYDLCSTCEKKGIHKEHNMIMFPTPL-----VYPRGRWFRKMHHGVPNFPWMQ MATCH . . * *: .:.:: : ::* * CONSENSUS ?KC??CPDYDLCS?C??KG?H??H???????P????????????W?RK??H??????W??

Q6NWE4_DANRE Q6NWE4_DANRE QAQAQNQAQNQP---Q--------PGPSGAQ-QNQDAPENPNENGATASSQANVEYLKNI Q4TA60_TETNG Q4TA60_TETNG NQAPNASQSHGPDPNR--------PPAAAAAAA----AAAAAECSNPSASQANVDFLKNI B5X3Q9_SALSA B5X3Q9_SALSA AQSQAQPGPSGS---Q--------PGQAAPGDR----QPSDASSAASQQSQANMDYLKNI SQSTM_MOUSE SQSTM_MOUSE GWEMGPPGNWSP---R--------PPRAGDG-R----PCPTAESASAPPEDPNVNFLKNV SQSTM_RAT SQSTM_RAT GWEMGPPGNWSP---R--------PPRAGDG-R----PCPTAESASAPSEDPNVNFLKNV Q32PJ9_BOVIN Q32PJ9_BOVIN AWEMGTPGNWSP---R--------PPQAGDA-H----PGPATESASGPSEDPSVNFLKNV A7E3V0_BOVIN A7E3V0_BOVIN AWEMGTPGNWSP---R--------PPQAGDA-H----PGPATESASGPSEDPSVNFLKNV Q13502_HUMAN Q13502_HUMAN AWDMGTPGNWSP---R--------PPQAGDA-H----PGPATESASGPSEDPSVNFLKNV B4E3V2_HUMAN B4E3V2_HUMAN GWEMGPPGNWIP---R--------PPRAGEA-R----PGPTAESASGPSEDPSVNFLKNV SQSTM_PONAB SQSTM_PONAB GWEMGPPGNWSP---R--------PPRAGEA-R----PGPTAESASGPSEDPSVNLLKNV A6NFN7_HUMAN A6NFN7_HUMAN GWEMGPPGNWSP---R--------PPRAGEA-R----PGPTAESASGPSEDPSVNFLKNV SQSTM_HUMAN SQSTM_HUMAN GWEMGPPGNWSP---R--------PPRAGEA-R----PGPTAESASGPSEDPSVNFLKNV Q66KM6_XENTR Q66KM6_XENTR GWAYPPRGYPCQ---NFQQAQESTPPQNETP-A----EEAAATSDSQSSQNPNVAFLKNV Q6PGS1_XENLA Q6PGS1_XENLA GWTVPPRGYPCH---KYQQAQESTPPQNEPP-A----EEAAASSDPQSSQNPNVDFLKNV MATCH . * .:..: ***: CONSENSUS ???????G????????????????PP?????????????????S?????????V??LKN?

Q6NWE4_DANRE Q6NWE4_DANRE GEEVAAMLSPLGIDVDIDVEHEGKRTKVTPTPPASSG----------PSSARSDSGSVGL Q4TA60_TETNG Q4TA60_TETNG GEGVAAMLSPLGIDVDIDVEHEGQRTKVT--TPLQSE--------------KAEKDLGAE B5X3Q9_SALSA B5X3Q9_SALSA GEGVAAMLSPLGIDVDIDVELEAKRTKVMTPNP------TPPGSGGPPSA-RSNNGTG-G SQSTM_MOUSE SQSTM_MOUSE GESVAAALSPLGIEVDIDVEHGGKRSRLTPTTPESSSTGTEDKSNTQPSS-CSSEVSKPD SQSTM_RAT SQSTM_RAT GESVAAALSPLGIEVDIDVEHGGKRSRLTPTSAESSSTGTEDKSGTQPSS-CSSEVSKPD Q32PJ9_BOVIN Q32PJ9_BOVIN GESVAAALSPLGIEVDIDVEHGGKRSRLTPTSAGSSS--TEEKCSSQPSS-CCSDPSKPD A7E3V0_BOVIN A7E3V0_BOVIN GESVAAALSPLGIEVDIDVEHGGKRSRLTPTSAGSSS--TEEKCSSQPSS-CCSDPSKPD Q13502_HUMAN Q13502_HUMAN GESVAAALSPLGIEVDIDVEHGGKRSRLTPTSAGSSS--TEEKCSSQPSS-CCSDPSKPD B4E3V2_HUMAN B4E3V2_HUMAN GESVAAALSPLGIEVDIDVEHGGKRSRLTPVSPESSS--TEEKSSSQPSS-CCSDPSKPG SQSTM_PONAB SQSTM_PONAB GESVAAALSPLGIEVDIDVEHGGKRSRLTPVSPESSS--TEEKSSSQPSS-CCSDPSKPG A6NFN7_HUMAN A6NFN7_HUMAN GESVAAALSPLGIEVDIDVEHGGKRSRLTPVSPESSS--TEEKSSSQPSS-CCSDPSKPG SQSTM_HUMAN SQSTM_HUMAN GESVAAALSPLGIEVDIDVEHGGKRSRLTPVSPESSS--TEEKSSSQPSS-CCSDPSKPG Q66KM6_XENTR Q66KM6_XENTR GESVAAMLSPLGIDVDIDVEHGGKRTKVSTSHPCSVDGDSQPNSSTSFTE-IQDIASRSD Q6PGS1_XENLA Q6PGS1_XENLA GESVAAMLSPLGIDVDIDVEHGGKRTKVSTSHPCSVDGNSQPNSSNFFME-SQEIGSRSD MATCH ** *** ******:****** .:*::: . . CONSENSUS GE?VAA?LSPLGI?VDIDVEH?GKR?????????S?????????????????????S???

Q6NWE4_DANRE Q6NWE4_DANRE LSRGSGPGSQATE------------ESVSEGTKKDQCS----DEEWTHLSAKEVDPSTGE Q4TA60_TETNG Q4TA60_TETNG AKDG-GEVTSDCNTSE---------GTKQGHRDS--------DEEWTHLSPKEVDPSTGE B5X3Q9_SALSA B5X3Q9_SALSA SEGD-GTKEG---DMEVDELSSL--GSASDLLTGGKDAGGSGDDEWTHLTSKEVDPSTGE SQSTM_MOUSE SQSTM_MOUSE GAGE-GPAQSLTEQMKKIALESV--GQPEEQMESGNCSGG--DDDWTHLSSKEVDPSTGE SQSTM_RAT SQSTM_RAT GAGE-GPAQSLTEQMKKIALESV--GQPEELMESDNCSGG--DDDWTHLSSKEVDPSTGE Q32PJ9_BOVIN Q32PJ9_BOVIN RDVE-GTAQSLTEQMNKIALESG--GQHEEQMESDNCSGG--DDDWTHLSSKEVDPSTGE A7E3V0_BOVIN A7E3V0_BOVIN RDVE-GTAQSLTEQMNKIALESG--GQHEEQMESDNCSGG--DDDWTHLSSKEVDPSTGE Q13502_HUMAN Q13502_HUMAN RDVE-GTAQSLTEQMNKIALESG--GQHEEQMESDNCSGG--DDDWTHLSSKEVDPSTGE B4E3V2_HUMAN B4E3V2_HUMAN GNVE-GATQSLAEQMRKIALESE--GRPEEQMESDNCSGG--DDDWTHLSSKEVDPSTGE SQSTM_PONAB SQSTM_PONAB GNVE-GATQSLAEQMRKIALESE--GRPEEQMESDNCSGG--DDDWTHLSSKEVDPSTGE A6NFN7_HUMAN A6NFN7_HUMAN GNVE-GATQSLAEQMRKIALESE--GRPEEQMESDNCSGG--DDDWTHLSSKEVDPSTGE SQSTM_HUMAN SQSTM_HUMAN GNVE-GATQSLAEQMRKIALESE--GRPEEQMESDNCSGG--DDDWTHLSSKEVDPSTGE Q66KM6_XENTR Q66KM6_XENTR SAPNLMETEHIAKRMKDIALNSPLPQDNEQGENSSSASGG--DDDWTHVSSKEVDPSTGE Q6PGS1_XENLA Q6PGS1_XENLA SSPNLMETEQIAKRMKDIALNSSLPQDNEQGENSNGTAVG--DDDWTHVSSKEVDPSTGE MATCH . *::***::.********* CONSENSUS ?????G????????M????L?S???????????S?????G??DD?WTHLSSKEVDPSTGE

Q6NWE4_DANRE Q6NWE4_DANRE LQSLRLEQDG-----ADLPAPLNTASGTSTRE------GPTGLREAALYPHLPQDADPRL Q4TA60_TETNG Q4TA60_TETNG LQSLQ---NQ-----G-LPSG-----------------GPAGLKEAALYPHLPEEADPRL B5X3Q9_SALSA B5X3Q9_SALSA LQSLRIGEEGSLEAPGSPTVPQG-----PSQEPQ----KSLTLAEAAAYPHLPQDADPRL SQSTM_MOUSE SQSTM_MOUSE LQSLQMPESE-----G--PSSLD-----PSQE------GPTGLKEAALYPHLPPEADPRL SQSTM_RAT SQSTM_RAT LQSLQMPESE-----G--PSSLD-----PSQE------GPTGLKEAALYPHLPPEADPRL Q32PJ9_BOVIN Q32PJ9_BOVIN LQSLQMPESE-----G--PSSLD-----PSQE------GPTGLKEAALYPHLPPEADPRL A7E3V0_BOVIN A7E3V0_BOVIN LQSLQMPESE-----G--PSSLD-----PSQE------GPTGLKEAALYPHLPPEADPRL Q13502_HUMAN Q13502_HUMAN LQSLQMPESE-----G--PSSLD-----PSQE------GPTGLKEAALYPHLPPEADPRL B4E3V2_HUMAN B4E3V2_HUMAN LQSLQMPESE-----G--PSSLD-----PSQE------GPTGLKEAALYPHLPPEADPRL SQSTM_PONAB SQSTM_PONAB LQSLQMPESE-----G--PSSLD-----PSQE------GPTGLKEAALYPHLPPEADPRL A6NFN7_HUMAN A6NFN7_HUMAN LQSLQMPESE-----G--PSSLD-----PSQE------GPTGLKEAALYPHLPPEADPRL SQSTM_HUMAN SQSTM_HUMAN LQSLQMPESE-----G--PSSLD-----PSQE------GPTGLKEAALYPHLPPEADPRL Q66KM6_XENTR Q66KM6_XENTR LQSLQLMETG-----Q--PCSLD-----PTRSSALPTHAPTGLREAALYPHLPPEADPRL Q6PGS1_XENLA Q6PGS1_XENLA LQSLQLIETG-----Q--PCSLD-----PNRSSAVPTHAPTGLREAALYPHLPPEADPRL MATCH ****: . . * *** ***** :***** CONSENSUS LQSLQ??E??????????P??L??????P??????????PTGL?EAALYPHLP?EADPRL

Q6NWE4_DANRE Q6NWE4_DANRE VESLSQMLSMGFTDEGGWLTRLLHTKNYDIGGALDTIQYSKTPGQQK Q4TA60_TETNG Q4TA60_TETNG VESLAQMLSMGFTDEGGWLTRLLQAKNFDIGAALDAIQFARHP---- B5X3Q9_SALSA B5X3Q9_SALSA VESLSQMLAMGFTDEGGWLTRLLHTKDCDVGAALDTIHYSK-PGKK- SQSTM_MOUSE SQSTM_MOUSE IESLSQMLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKHPPPL- SQSTM_RAT SQSTM_RAT IESLSQMLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKHPPPL- Q32PJ9_BOVIN Q32PJ9_BOVIN IESLSQMLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKHPPPL- A7E3V0_BOVIN A7E3V0_BOVIN IESLSQMLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKHPPPL- Q13502_HUMAN Q13502_HUMAN IESLSQMLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKHPPPL- B4E3V2_HUMAN B4E3V2_HUMAN IESLSQMLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKHPPPL- SQSTM_PONAB SQSTM_PONAB IESLSQMLSMGFSDEGGRLTRLLQTKNYDIGAALDTIQYSKHPPPL- A6NFN7_HUMAN A6NFN7_HUMAN IESLSQMLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKHPPPL- SQSTM_HUMAN SQSTM_HUMAN IESLSQMLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKHPPPL- Q66KM6_XENTR Q66KM6_XENTR IESLSQMLSMGFTDEGGWLTRLLEAKQFDIGSALDAMQSIRHIPPS- Q6PGS1_XENLA Q6PGS1_XENLA IETLSQMLSMGFSDEGGWLTRLLEAKQYDIGSALDAMQSIRHIPNS- MATCH :*:*:***:***:**** *****.:*: *:*.***::: : CONSENSUS ?ESLSQMLSMGF?DEGGWLTRLL??K??DIG?ALD?IQ???HP????


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