Alignment of the gene Family HBG053404 of HOVERGEN

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Threshold: 50% 80% 100%
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Isoforms are ON
Q5RGW1_DANRE Q5RGW1_DANRE ------------------------------------------------------------ Q4RJU9_TETNG Q4RJU9_TETNG ------------------------------------------------------------ Q6DSU3_DANRE Q6DSU3_DANRE --------------------------------------------------MPPSAADRRS B5DE65_XENTR B5DE65_XENTR QGWHRGQGTRGIIAQGEPKGCAAGTRAEGSAPTSPQRHPYPRTHIPAPISPHPHPSTLIP Q0P4P1_XENTR Q0P4P1_XENTR ------------------------------------------------------------ PLXD1_HUMAN PLXD1_HUMAN ----------------------------------MAPRAAGGAPLSARAAAASPPPFQTP Q3UH93_MOUSE Q3UH93_MOUSE --------------------------------MARRAAGGAPPSARAAAAVPLRPRPHSR Q68HV1_MOUSE Q68HV1_MOUSE --------------------------------MARRAAGGAPPSAWAAAAVPLRPRPHSR Q6ZQ83_MOUSE Q6ZQ83_MOUSE ------------------------------------------------------------ Q3U3W7_MOUSE Q3U3W7_MOUSE ------------------------------------------------------------ B2RXS4_MOUSE B2RXS4_MOUSE -----------------------------------------------------------M Q3UH76_MOUSE Q3UH76_MOUSE -----------------------------------------------------------M Q5RAK5_PONAB Q5RAK5_PONAB -----------------------------------------------------------M A6QRH2_HUMAN A6QRH2_HUMAN -----------------------------------------------------------M PLXB2_HUMAN PLXB2_HUMAN -----------------------------------------------------------M Q3LIB1_HUMAN Q3LIB1_HUMAN ------------------------------------------------------------ Q4T033_TETNG Q4T033_TETNG ------------------------------------------------------------ Q5RH91_DANRE Q5RH91_DANRE ------------------------------------------------------------ A2AFF9_MOUSE A2AFF9_MOUSE -----------------------------------------------MLTDFLQAPVMAP PLXB3_MOUSE PLXB3_MOUSE ---------------------------------------------------------MAP B7Z3E6_HUMAN B7Z3E6_HUMAN ----------------MELTPASSLTCSLLSPRLPGSFPQLRRVPPCSRPWLPKAPVMAR A8K920_HUMAN A8K920_HUMAN ---------------------------------------MCHAAQETPLLHHFMAPVMAR B7Z3H9_HUMAN B7Z3H9_HUMAN ------------------------------------------------------------ PLXB3_HUMAN PLXB3_HUMAN ---------------------------------------MCHAAQETPLLHHFMAPVMAR B0V3R5_DANRE B0V3R5_DANRE ------------------------------------------------------------ Q4TAV0_TETNG Q4TAV0_TETNG ------------------------------------------------------------ Q4T1S7_TETNG Q4T1S7_TETNG ------------------------------------------------------------ A6H8Y2_HUMAN A6H8Y2_HUMAN ------------------------------------------------------MPALGP PLXB1_HUMAN PLXB1_HUMAN ------------------------------------------------------MPALGP B2RWT9_MOUSE B2RWT9_MOUSE ------------------------------------------------------MSVLGP PLXB1_MOUSE PLXB1_MOUSE ------------------------------------------------------MSVLGP MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RGW1_DANRE Q5RGW1_DANRE ------------------------------------------------------------ Q4RJU9_TETNG Q4RJU9_TETNG ------------------------------------------------------------ Q6DSU3_DANRE Q6DSU3_DANRE AL--------ALLSALLLAALQTRSAGALHVQQAFATPGRTNNFALDAASGRVYLAAVNN B5DE65_XENTR B5DE65_XENTR APISQHPYPCPLMAAAVLLLSLVALASGLELVSKFHSPQVTNNFALSAGEGLLYLAAVNR Q0P4P1_XENTR Q0P4P1_XENTR ------------MAAAVLLLSLVALASGLELVSKFHSPQVTNNFALSAGEGLLYLAAVNR PLXD1_HUMAN PLXD1_HUMAN PR--------CPVPLLLLLLLGAARAGALEIQRRFPSPTPTNNFALDGAAGTVYLAAVNR Q3UH93_MOUSE Q3UH93_MOUSE GP--------GLLPLPLLLLLGAARAGALEIQRRFPSPTPTNNFALDGTAGTVYLAAVNR Q68HV1_MOUSE Q68HV1_MOUSE GP--------GLLPLPLLLLLGAARAGALEIQRRFPSPTPTNNFALDGTAGTVYLAAVNR Q6ZQ83_MOUSE Q6ZQ83_MOUSE ------------------------------------------------------------ Q3U3W7_MOUSE Q3U3W7_MOUSE ------------------------------------------------------------ B2RXS4_MOUSE B2RXS4_MOUSE AL--------PLWALTFLGLTGLGLSLRSRKPESFRSETELNHLAVDEVTGVVYVGAVNA Q3UH76_MOUSE Q3UH76_MOUSE AL--------PLWALTFLGLTGLGLSLRSRKPESFRSETELNHLAVDEVTGVVYVGAVNA Q5RAK5_PONAB Q5RAK5_PONAB AL--------QLWALTLLGLLGAGASLRPRKLDFFRSEKELNHLAVDEASGVVYLGAVNT A6QRH2_HUMAN A6QRH2_HUMAN AL--------QLWALTLLGLLGAGASLRPRKLDFFRSEKELNHLAVDEASGVVYLGAVNA PLXB2_HUMAN PLXB2_HUMAN AL--------QLWALTLLGLLGAGASLRPRKLDFFRSEKELNHLAVDEASGVVYLGAVNA Q3LIB1_HUMAN Q3LIB1_HUMAN ------------------------------------------------------------ Q4T033_TETNG Q4T033_TETNG ------------------------------------------------------------ Q5RH91_DANRE Q5RH91_DANRE ------------------------------------------------------------ A2AFF9_MOUSE A2AFF9_MOUSE WS--------PFSLHLLLLFL--PLLPLTRVHRFSVPNTSFNHLVLAPDQGKLYVGAVNH PLXB3_MOUSE PLXB3_MOUSE WS--------PFSLHLLLLFL--PLLPLTRVHRFSVPNTSFNHLVLAPDQGKLYVGAVNH B7Z3E6_HUMAN B7Z3E6_HUMAN WP--------PFGLCLLLLLLSPPPLPLTGAHRFSAPNTTLNHLALAPGRGTLYVGAVNR A8K920_HUMAN A8K920_HUMAN WP--------PFGLCLLLLLLSPPPLPLTGAHRFSAPNTTLNHLALAPGRGTLYVGAVNR B7Z3H9_HUMAN B7Z3H9_HUMAN -------------------------------MCHAAQETPLLH----------------- PLXB3_HUMAN PLXB3_HUMAN WP--------PFGLCLLLLLLSPPPLPLTGAHRFSAPNTTLNHLALAPGRGTLYVGAVNR B0V3R5_DANRE B0V3R5_DANRE ------------------------------------------------------------ Q4TAV0_TETNG Q4TAV0_TETNG ------------------------------------------------------------ Q4T1S7_TETNG Q4T1S7_TETNG ------------------------------------------------------MAVVTS A6H8Y2_HUMAN A6H8Y2_HUMAN ALLQ------ALWAGWVLTLQPLPP------TAFTPNGTYLQHLARDPTSGTLYLGATNF PLXB1_HUMAN PLXB1_HUMAN ALLQ------ALWAGWVLTLQPLPP------TAFTPNGTYLQHLARDPTSGTLYLGATNF B2RWT9_MOUSE B2RWT9_MOUSE VLLQ------VFWAGCVVTLRSPLP------AAFTANGTHLQHLARDPTTGTLYVGATNF PLXB1_MOUSE PLXB1_MOUSE VLLQ------VFWAGCVVTLRSPLP------AAFTANGTHLLHLARDPTTGTLYVGATNF MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RGW1_DANRE Q5RGW1_DANRE ------------------------------------------------------------ Q4RJU9_TETNG Q4RJU9_TETNG ------------------------------------------------------------ Q6DSU3_DANRE Q6DSU3_DANRE LYQLNATLALEVE-MRTGPVLDNPLCHAPQLPQATCEHQKTLTDNHNKLLALDRAQDVLL B5DE65_XENTR B5DE65_XENTR IYQLNWELRPELE-DVTGPVPDSPLCHAPQLRETTCDFPRTSTPNYNKILLPDPEQGLLL Q0P4P1_XENTR Q0P4P1_XENTR IYQLNWELRPELE-DVTGPVPDSPLCHAPQLRETTCDFPRTSTPNYNKILLPDPEQGLLL PLXD1_HUMAN PLXD1_HUMAN LYQLSGANLSLEAEAAVGPVPDSPLCHAPQLPQASCEHPRRLTDNYNKILQLDPGQGLVV Q3UH93_MOUSE Q3UH93_MOUSE LYQLSSANLSLEAEATVGPVPDSPLCHAPQLPQASCEHPRRLTDNYNKILQLDPGQGLVV Q68HV1_MOUSE Q68HV1_MOUSE LYQLSSANLSLEAEATVGPVPDSPLCHAPQLPQASCEHPRRLTDNYNKILQLDPGQGLVV Q6ZQ83_MOUSE Q6ZQ83_MOUSE ------------------------------------------------------------ Q3U3W7_MOUSE Q3U3W7_MOUSE ------------------------------------------------------------ B2RXS4_MOUSE B2RXS4_MOUSE LYQLSADLHVQQH-VVTGPFMDNKKCTPPIEASQC--HEAVLTDNFNQLLLLDPPGKRLV Q3UH76_MOUSE Q3UH76_MOUSE LYQLSADLHVQQH-VVTGPFMDNKKCTPPIEASQC--HEAVLTDNFNQLLLLDPPGKRLV Q5RAK5_PONAB Q5RAK5_PONAB LYQLDAKLQLEQQ-VATGPALDNKKCTPPIEASQC--HEAEMTDNVNQLLLLDPPRKRLV A6QRH2_HUMAN A6QRH2_HUMAN LYQLDAKLQLEQ------------------------------------------------ PLXB2_HUMAN PLXB2_HUMAN LYQLDAKLQLEQQ-VATGPALDNKKCTPPIEASQC--HEAEMTDNVNQLLLLDPPRKRLV Q3LIB1_HUMAN Q3LIB1_HUMAN ------------------------------------------------------------ Q4T033_TETNG Q4T033_TETNG ------------------------------------------------------------ Q5RH91_DANRE Q5RH91_DANRE ------------------------------------------------------------ A2AFF9_MOUSE A2AFF9_MOUSE LFQLSPELKMESV-AVTGPVIDSPDCVPFRDLAEC--PQAQLTDNANQLLLVSSRTQELV PLXB3_MOUSE PLXB3_MOUSE LFQLSPELKMESV-AVTGPVIDSPDCVPFRDLAEC--PQAQLTDNANQLLLVSSRTQELV B7Z3E6_HUMAN B7Z3E6_HUMAN LFQLSPELQLEAV-AVTGPVIDSPDCVPFRDPAEC--PQAQLTDNANQLLLVSSRAQELV A8K920_HUMAN A8K920_HUMAN LFQLSPELQLEAV-AVTGPVIDSPDCVPFRDPAEC--PQAQLTDNANQLLLVSSRAQELV B7Z3H9_HUMAN B7Z3H9_HUMAN ------------------------------------------------------------ PLXB3_HUMAN PLXB3_HUMAN LFQLSPELQLEAV-AVTGPVIDSPDCVPFRDPAEC--PQAQLTDNANQLLLVSSRAQELV B0V3R5_DANRE B0V3R5_DANRE ------------------------------------------------------------ Q4TAV0_TETNG Q4TAV0_TETNG ------------------------------------------------------------ Q4T1S7_TETNG Q4T1S7_TETNG NVKTSPAVTMSAMDVAPDAVVPSKDLDPA------------------------------- A6H8Y2_HUMAN A6H8Y2_HUMAN LFQLSPGLQLEAT-VSTGPVLDSRDCLPPVMPDEC--PQAQPTNNPNQLLLVSPGA--LV PLXB1_HUMAN PLXB1_HUMAN LFQLSPGLQLEAT-VSTGPVLDSRDCLPPVMPDEC--PQAQPTNNPNQLLLVSPGA--LV B2RWT9_MOUSE B2RWT9_MOUSE LFQLSPGLQLEAV-VSTGPVNDSRDCLPPVIPDEC--PQAQPTNNPNQLLLVSPEA--LV PLXB1_MOUSE PLXB1_MOUSE LFQLSPGLQLEAV-VSTGPVNDSRDCLPPVIPDEC--PQAQPTNNPNQLLLVSPEA--LV MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RGW1_DANRE Q5RGW1_DANRE ------------------------------------------------------------ Q4RJU9_TETNG Q4RJU9_TETNG ------------------------------------------------------------ Q6DSU3_DANRE Q6DSU3_DANRE ACGSVYQGFCELRRLENVSRLAVQFPQDG-----ATVFPSMLNIAANHENASTVGLVFRT B5DE65_XENTR B5DE65_XENTR TCGSIFQGLCELRALRNITLRAVPFPVDN-------AVPSMLNVAANHPNASTVGLLLRG Q0P4P1_XENTR Q0P4P1_XENTR TCGSIFQGLCELRALRNITLRAVPFPVDN-------AVPSMLNVAANHPNASTVGLLLRG PLXD1_HUMAN PLXD1_HUMAN VCGSIYQGFCQLRRRGNISAVAVRFPPAAPPAEPVTVFPSMLNVAANHPNASTVGLVLPP Q3UH93_MOUSE Q3UH93_MOUSE ACGSIYQGLCQLRRRGNISALAVSFPPAAPTAEPVTVFPSMLNVAANHPNASTVGLVLPP Q68HV1_MOUSE Q68HV1_MOUSE ACGSIYQGLCQLRRRGNISALAVSFPPAAPTAEPVTVFPSMLNVAANHPNASTVGLVLPP Q6ZQ83_MOUSE Q6ZQ83_MOUSE ---------------------------------------SMLNVAANHPNASTVGLVLPP Q3U3W7_MOUSE Q3U3W7_MOUSE ------------------------------------------------------------ B2RXS4_MOUSE B2RXS4_MOUSE ECGSLFKGICALRAMSNISVRLFYEDGSG----------EKSFVASNDERVATVGLVTST Q3UH76_MOUSE Q3UH76_MOUSE ECGSLFKGICALRAMSNISVRLFYEDGSG----------EKSFVASNDERVATVGLVTST Q5RAK5_PONAB Q5RAK5_PONAB ECGSPFKGICALRALSNISLRLFYEDGSG----------EKSFVASNDEGVATVGLVSST A6QRH2_HUMAN A6QRH2_HUMAN ------------------------------------------------------------ PLXB2_HUMAN PLXB2_HUMAN ECGSLFKGICALRALSNISLRLFYEDGSG----------EKSFVASNDEGVATVGLVSST Q3LIB1_HUMAN Q3LIB1_HUMAN ------------------------------------------------------------ Q4T033_TETNG Q4T033_TETNG ------------------------------------------------------------ Q5RH91_DANRE Q5RH91_DANRE ------------------------------------------------------------ A2AFF9_MOUSE A2AFF9_MOUSE ACGQVKQGVCEKRRLGDVTQVLYQAEDPG----------DGQFVAANTLGVTTVGLVVPL PLXB3_MOUSE PLXB3_MOUSE ACGQVKQGVCEKRRLGDVTQVLYQAEDPG----------DGQFVAANTLGVTTVGLVVPL B7Z3E6_HUMAN B7Z3E6_HUMAN ACGQVRQGVCETRRLGDVVEVLYQAEDPG----------DGQFVAANTPGVATVGLVVPL A8K920_HUMAN A8K920_HUMAN ACGQVRQGVCETRRLGDVAEVLYQAEDPG----------DGQFVAANTPGVATVGLVVPL B7Z3H9_HUMAN B7Z3H9_HUMAN ------------------------------------------------------------ PLXB3_HUMAN PLXB3_HUMAN ACGQVRQGVCETRRLGDVAEVLYQAEDPG----------DGQFVAANTPGVATVGLVVPL B0V3R5_DANRE B0V3R5_DANRE ------------------------------------------------------------ Q4TAV0_TETNG Q4TAV0_TETNG ------------------------------------------------------------ Q4T1S7_TETNG Q4T1S7_TETNG ---------------------------------------MPLFIPPPDPDSSTLDVVTAS A6H8Y2_HUMAN A6H8Y2_HUMAN VCGSVHQGVCEQRRLGQLEQLLLRPERPG----------DTQYVAANDPAVSTVGLVAQG PLXB1_HUMAN PLXB1_HUMAN VCGSVHQGVCEQRRLGQLEQLLLRPERPG----------DTQYVAANDPAVSTVGLVAQG B2RWT9_MOUSE B2RWT9_MOUSE VCGSIHQGICELRSLGQIRQLLLRPERPG----------DTQYVAANDPAVSTVGLVAQG PLXB1_MOUSE PLXB1_MOUSE VCGSVHQGICELRSLGQIRQLLLRPERPG----------DTQYVAANDPAVSTVGLVAQG MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RGW1_DANRE Q5RGW1_DANRE ------------------------------------------------------------ Q4RJU9_TETNG Q4RJU9_TETNG ------------------------------------------------------------ Q6DSU3_DANRE Q6DSU3_DANRE HG--GSPRLLVGATYTGMGTEYFPKNHSKEDLRFENTPEIAIRALDTRELG-RLFTYDIN B5DE65_XENTR B5DE65_XENTR PS--GDTKLLVGATYTGYSSQFFPWNQSIADHRFENSPEISIRALNL-TASEKLFTFDIS Q0P4P1_XENTR Q0P4P1_XENTR PS--GDTKLLVGATYTGYSSQFFPWNQSIADHRFENSPEISIRALNL-TASEKLFTFDIS PLXD1_HUMAN PLXD1_HUMAN AAGAGGSRLLVGATYTGYGSSFFPRNRSLEDHRFENTPEIAIRSLDTRGDLAKLFTFDLN Q3UH93_MOUSE Q3UH93_MOUSE TSGTGGSRLLVGATYTGFGSAFFPRNRSLEDHRFENTPEIAIRSLDARGDLAKLFTFDLN Q68HV1_MOUSE Q68HV1_MOUSE TSGTGGSRLLVGATYTGFGSAFFPRNRSLEDHRFENTPEIAIRSLDARGDLAKLFTFDLN Q6ZQ83_MOUSE Q6ZQ83_MOUSE TSGTGGSRLLVGATYTGFGSAFFPRNRSLEDHRFENTPEIAIRSLDARGDLAKLFTFDLN Q3U3W7_MOUSE Q3U3W7_MOUSE ------------------------------------------------------------ B2RXS4_MOUSE B2RXS4_MOUSE RPD-GERVLFVGKGNGPH------------------------------DNGIIVSTRLLD Q3UH76_MOUSE Q3UH76_MOUSE RPD-GERVLFVGKGNGPH------------------------------DNGIIVSTRLLD Q5RAK5_PONAB Q5RAK5_PONAB GPG-GDRVLFVGKGNGPH------------------------------DNGIIVSTRLLD A6QRH2_HUMAN A6QRH2_HUMAN ------------------------------------------------------------ PLXB2_HUMAN PLXB2_HUMAN GPG-GDRVLFVGKGNGPH------------------------------DNGIIVSTRLLD Q3LIB1_HUMAN Q3LIB1_HUMAN ------------------------------------------------------------ Q4T033_TETNG Q4T033_TETNG ------------------------------------------------------------ Q5RH91_DANRE Q5RH91_DANRE ------------------------------------------------------------ A2AFF9_MOUSE A2AFF9_MOUSE P---GRDLLLVARGLAGKL-----------------------------SAGVPPLTVRQL PLXB3_MOUSE PLXB3_MOUSE P---GRDLLLVARGLAGKL-----------------------------SAGVPPLTVRQL B7Z3E6_HUMAN B7Z3E6_HUMAN P---GRDLLLVARGLAGKL-----------------------------SAGVPPLAIRQL A8K920_HUMAN A8K920_HUMAN P---GRDLLLVARGLAGKL-----------------------------SAGVPPLAIRQL B7Z3H9_HUMAN B7Z3H9_HUMAN ------------------------------------------------------------ PLXB3_HUMAN PLXB3_HUMAN P---GRDLLLVARGLAGKL-----------------------------SAGVPPLAIRQL B0V3R5_DANRE B0V3R5_DANRE ------------------------------------------------------------ Q4TAV0_TETNG Q4TAV0_TETNG ------------------------------------------------------------ Q4T1S7_TETNG Q4T1S7_TETNG SPSTPHET----------------------------------------KGASGMVETRAL A6H8Y2_HUMAN A6H8Y2_HUMAN LA--GEPLLFVGRGYTSRGV----------------------------GGGIPPITTRAL PLXB1_HUMAN PLXB1_HUMAN LA--GEPLLFVGRGYTSRGV----------------------------GGGIPPITTRAL B2RWT9_MOUSE B2RWT9_MOUSE LV--GEPLLFVGRGYTSRGV----------------------------GGGIPPITTRAL PLXB1_MOUSE PLXB1_MOUSE LV--GEPLLFVGRGYTSRGV----------------------------GGGIPPITTRAL MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RGW1_DANRE Q5RGW1_DANRE ------------------------------------------------------------ Q4RJU9_TETNG Q4RJU9_TETNG ------------------------------------------------------------ Q6DSU3_DANRE Q6DSU3_DANRE PSEDNVFKIKQEVKQKNKL--------SFVHAFALGNYSYIAFNNDANSGLKESQPNSVL B5DE65_XENTR B5DE65_XENTR PSDDNIFKVKQSFKARHRLG--------FVRAFQQGPFAYLAMNVEPAPAGKENRPSSVL Q0P4P1_XENTR Q0P4P1_XENTR PSDDNIFKVKQSFKARHRLG--------FVRAFQQGPFAYLAMNVEPAPAGKENRPSSVL PLXD1_HUMAN PLXD1_HUMAN PSDDNILKIKQGAKEQHKLGFVSAFLHPSDPPPGAQSYAYLALNSEARAGDKESQARSLL Q3UH93_MOUSE Q3UH93_MOUSE PSDDNILKIKQGAKEQHKLGFVRAFLHPAVPPHSAQPYAYLALNSEARAGDKDSQARSLL Q68HV1_MOUSE Q68HV1_MOUSE PSDDNILKIKQGAKEQHKLGFVRAFLHPAVPPHSAQPYAYLALNSEARAGDKDSQARSLL Q6ZQ83_MOUSE Q6ZQ83_MOUSE PSDDNILKIKQGAKEQHKLGFVRAFLHPAVPPHSAQPYAYLALNSEARAGDKDSQARSLL Q3U3W7_MOUSE Q3U3W7_MOUSE ------------------------------------------------------------ B2RXS4_MOUSE B2RXS4_MOUSE RAEGREAFEAYSDHTTFKAGYLSTNTQQFVAAFEDDFYVFFVFNHQDKHPAKN---RTLL Q3UH76_MOUSE Q3UH76_MOUSE RAEGREAFEAYSDHTTFKAGYLSTNTQQFVAAFEDDFYVFFVFNHQDKHPAKN---RTLL Q5RAK5_PONAB Q5RAK5_PONAB RTDSREAFEAYTDHATYKAGYLSTNTQQFVAAFEDGPYVFFVFNQQDKHPARN---RTLL A6QRH2_HUMAN A6QRH2_HUMAN ------------------------------------------------------------ PLXB2_HUMAN PLXB2_HUMAN RTDSREAFEAYTDHATYKAGYLSTNTQQFVAAFEDGPYVFFVFNQQDKHPARN---RTLL Q3LIB1_HUMAN Q3LIB1_HUMAN ------------------------------------------------------------ Q4T033_TETNG Q4T033_TETNG ------------------------------------------------------------ Q5RH91_DANRE Q5RH91_DANRE ------------------------------------------------------------ A2AFF9_MOUSE A2AFF9_MOUSE AGPQP---FSSEGLGRLVVGDFSDYNNSYVGAFSDAHSAYFVFRRRGARAQTEY--RSYV PLXB3_MOUSE PLXB3_MOUSE AGPQP---FSSEGLGRLVVGDFSDYNNSYVGAFSDAHSAYFVFRRRGARAQTEY--RSYV B7Z3E6_HUMAN B7Z3E6_HUMAN AGSQP---FSSEGLGRLVVGDFSDYNNSYVGAFADARSAYFVFRRRGARAQAEY--RSYV A8K920_HUMAN A8K920_HUMAN AGSQP---FSSEGLGRLVVGDFSDYNNSYVGAFADARSAYFVFRRRGARAQAEY--RSYV B7Z3H9_HUMAN B7Z3H9_HUMAN ------------------------------------------------------------ PLXB3_HUMAN PLXB3_HUMAN AGSQP---FSSEGLGRLVVGDFSDYNNSYVGAFADARSAYFVFRRRGARAQAEY--RSYV B0V3R5_DANRE B0V3R5_DANRE ------------------------------------------------------------ Q4TAV0_TETNG Q4TAV0_TETNG ------------------------------------------------------------ Q4T1S7_TETNG Q4T1S7_TETNG PSE-----------------------------VTAQSTPFFVMEPDDSESS--------- A6H8Y2_HUMAN A6H8Y2_HUMAN WPPDPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFLFLRRDLQAQSRAF-RAYV PLXB1_HUMAN PLXB1_HUMAN WPPDPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFLFLRRDLQAQSRAF-RAYV B2RWT9_MOUSE B2RWT9_MOUSE RPPDPQAAFSYEETAKLAVGRLSEYSHHFVSAFVRGASAYFLFLRRDLKAPSRAF-RAYV PLXB1_MOUSE PLXB1_MOUSE RPPDPQAAFSYEETAKLAVGRLSEYSHHFVSAFVRGASAYFLFLRRDLKAPSRAF-RAYV MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RGW1_DANRE Q5RGW1_DANRE ------------------------------------------------------------ Q4RJU9_TETNG Q4RJU9_TETNG ------------------------------------------------------------ Q6DSU3_DANRE Q6DSU3_DANRE ARICLDTDAPRRAAESRKLTESYAQMGLRCG--------TYTRLLSVSPAELRAETFLFA B5DE65_XENTR B5DE65_XENTR ARICLKSEP---RTEPRKLTESYIQLGLRCEGPG-------GVLYGRLLSVFAESENIFG Q0P4P1_XENTR Q0P4P1_XENTR ARICLKSEP---RTEPRKLTESYIQLGLRCEGPG-------GVLYGRLLSVFAESENIFG PLXD1_HUMAN PLXD1_HUMAN ARICLPHGA---GGDAKKLTESYIQLGLQCAGGA-----GRGDLYSRLVSVFPARERLFA Q3UH93_MOUSE Q3UH93_MOUSE ARICLPRGA---GGDAKKLTESYIQLGLQCAGGA-----GRGDLYSRLVSVFPAREQFFA Q68HV1_MOUSE Q68HV1_MOUSE ARICLPRGA---GGDAKKLTESYIQLGLQCAGGA-----GRGDLYSRLVSVFPAREQFFA Q6ZQ83_MOUSE Q6ZQ83_MOUSE ARICLPRGA---GGDAKKLTESYIQLGLQCAGGA-----GRGDLYSRLVSVFPAREQFFA Q3U3W7_MOUSE Q3U3W7_MOUSE ------------------------------------------------------------ B2RXS4_MOUSE B2RXS4_MOUSE ARMCKDDPS----------YYSYVEMDLQCQDPSDPQDSAFGTCLAASVATSGAGRALYA Q3UH76_MOUSE Q3UH76_MOUSE ARMCKDDPS----------YYSYVEMDLQCQDPSDPQDSAFGTCLAASVATSGAGRALYA Q5RAK5_PONAB Q5RAK5_PONAB ARMCREDPN----------YYSYLEMDLQCRDPDV-HAAAFGTCLAASVAAPGSGRVLYA A6QRH2_HUMAN A6QRH2_HUMAN ------------------------------------------------------------ PLXB2_HUMAN PLXB2_HUMAN ARMCREDPN----------YYSYLEMDLQCRDPDI-HAAAFGTCLAASVAAPGSGRVLYA Q3LIB1_HUMAN Q3LIB1_HUMAN ------------------------------------------------------------ Q4T033_TETNG Q4T033_TETNG ------------------------------------------------------------ Q5RH91_DANRE Q5RH91_DANRE ------------------------------------------------------------ A2AFF9_MOUSE A2AFF9_MOUSE ARVCLRDVN----------LYSYVEMPLTCHGQGL------------IQAAFLTPDTLLG PLXB3_MOUSE PLXB3_MOUSE ARVCLRDVN----------LYSYVEMPLTCHGQGL------------IQAAFLTPDTLLG B7Z3E6_HUMAN B7Z3E6_HUMAN ARVCLGDTN----------LYSYVEVPLACQGQGL------------IQAAFLAPGTLPG A8K920_HUMAN A8K920_HUMAN ARVCLGDTN----------LYSYVEVPLACQGQGL------------IQAAFLAPGTLLG B7Z3H9_HUMAN B7Z3H9_HUMAN ------------------------------------------------------------ PLXB3_HUMAN PLXB3_HUMAN ARVCLGDTN----------LYSYVEVPLACQGQGL------------IQAAFLAPGTLLG B0V3R5_DANRE B0V3R5_DANRE ------------------------------------------------------------ Q4TAV0_TETNG Q4TAV0_TETNG ------------------------------------------------------------ Q4T1S7_TETNG Q4T1S7_TETNG ------------------------------------------------------------ A6H8Y2_HUMAN A6H8Y2_HUMAN SRVCLRDQH----------YYSYVELPLACEGGRY---GLIQAAAVATSREVAHGEVLFA PLXB1_HUMAN PLXB1_HUMAN SRVCLRDQH----------YYSYVELPLACEGGRY---GLIQAAAVATSREVAHGEVLFA B2RWT9_MOUSE B2RWT9_MOUSE SRVCLQDQH----------YYSYVELPLACQGGRY---GLIQAAAVATSKEVARGDVLFA PLXB1_MOUSE PLXB1_MOUSE SRVCLQDQH----------YYSYVELPLACQGGRY---GLIQAAAVATSKEVARGDVLFA MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RGW1_DANRE Q5RGW1_DANRE ------------------------------------------------------------ Q4RJU9_TETNG Q4RJU9_TETNG ------------------------------------------------------------ Q6DSU3_DANRE Q6DSU3_DANRE VFG--------RADG-------RAAVCVFRVAEVEEMIRQGRRNCSHGPNSDVQVLDSVI B5DE65_XENTR B5DE65_XENTR IFE--------GKN--------EAALCMFPLRSVAQEIRGARRGCFESQDAGEVTVLDSV Q0P4P1_XENTR Q0P4P1_XENTR IFE--------GKN--------EAALCMFPLRSVAQEIRGARRGCFESQDAGEVTVLDSV PLXD1_HUMAN PLXD1_HUMAN VFE--------RPQGSPAARAAPAALCAFRFADVRAAIRAARTACFVEPAPDVVAVLDSV Q3UH93_MOUSE Q3UH93_MOUSE VFE--------RPQGAPGARNAPAALCAFRFDDVQAAIRAARTACFVEPAPDVVAVLDSV Q68HV1_MOUSE Q68HV1_MOUSE VFE--------RPQGAPGARNAPAALCAFRFDDVQAAIRAARTACFVEPAPDVVAVLDSV Q6ZQ83_MOUSE Q6ZQ83_MOUSE VFE--------RPQGAPGARNAPAALCAFRFDDVQAAIRAARTACFVEPAPDVVAVLDSV Q3U3W7_MOUSE Q3U3W7_MOUSE ------------------------------------------------------------ B2RXS4_MOUSE B2RXS4_MOUSE VFS--------RDGRSTGGP--GAGLCVFPLDKVREKIEANRNACYT--GAREAGRTIFY Q3UH76_MOUSE Q3UH76_MOUSE VFS--------RDGRSTGGP--GAGLCVFPLDKVREKIEANRNACYT--GAREAGRTIFY Q5RAK5_PONAB Q5RAK5_PONAB VFS--------RDSRSSGGP--GAGLCLFPLDEVHAKMEANRNACYT--GTWEASRDIFY A6QRH2_HUMAN A6QRH2_HUMAN ------------------------------------------------------------ PLXB2_HUMAN PLXB2_HUMAN VFS--------RDSRSSGGP--GAGLCLFPLDKVHAKMEANRNACYTG---TREARDIFY Q3LIB1_HUMAN Q3LIB1_HUMAN ------------------------------------------------------------ Q4T033_TETNG Q4T033_TETNG ------------------------------------------------------------ Q5RH91_DANRE Q5RH91_DANRE ------------------------------------------------------------ A2AFF9_MOUSE A2AFF9_MOUSE AFS--------AGTSQA-----QAALCAFPLADLDRSMEQARRLCYTTGGQGPSGMEEAT PLXB3_MOUSE PLXB3_MOUSE AFS--------AGTSQA-----QAALCAFPLADLDRSMEQARRLCYTTGGQGPSGMEEAT B7Z3E6_HUMAN B7Z3E6_HUMAN VFA--------AGPRGT-----QAALCAFPMVELGASMEQARRLCYTAGGRGPSGAEEAT A8K920_HUMAN A8K920_HUMAN VFA--------AGPRGT-----QAALCAFPMVGLGASMEQARRLCYTAGGRGPSGAEEAT B7Z3H9_HUMAN B7Z3H9_HUMAN ------------------------------------------------------------ PLXB3_HUMAN PLXB3_HUMAN VFA--------AGPRGT-----QAALCAFPMVELGASMEQARRLCYTAGGRGPSGAEEAT B0V3R5_DANRE B0V3R5_DANRE ------------------------------------------------------------ Q4TAV0_TETNG Q4TAV0_TETNG ------------------------------------------------------------ Q4T1S7_TETNG Q4T1S7_TETNG ------------------------------------------------------------ A6H8Y2_HUMAN A6H8Y2_HUMAN AFSSAAPPTVGRPPSAAAGASGASALCAFPLDEVDRLANRTRDACYTREGRAEDGTEVAY PLXB1_HUMAN PLXB1_HUMAN AFSSAAPPTVGRPPSAAAGASGASALCAFPLDEVDRLANRTRDACYTREGRAEDGTEVAY B2RWT9_MOUSE B2RWT9_MOUSE AFSSVAPPTVDWPLSASTGASGTSVLCAFPLDEVDQLANYTRDACYTREGRAENGTKVAD PLXB1_MOUSE PLXB1_MOUSE AFSSVAPPTVDWPLSASTGASGTSVLCAFPLDEVDQLANYTRDACYTREGRAENGTKVAD MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RGW1_DANRE Q5RGW1_DANRE ---------------------------------SDLQPLSVV----FKSSSMSSVAAVRN Q4RJU9_TETNG Q4RJU9_TETNG ----------------------------------------------------------MA Q6DSU3_DANRE Q6DSU3_DANRE QGSGAECEGKGSIMLQLQTDQLNCGAAHLQHPLALRRPLRARPLYEAQG--LSSVAVDSA B5DE65_XENTR B5DE65_XENTR VQGTGPSCERRNAKVKLQEEQLDCGAAHLQHPLAITRPLPAVPIYKEKG--LTSVAVANV Q0P4P1_XENTR Q0P4P1_XENTR VQGTGPSCERRNAKVKLQEEQLDCGAAHLQHPLAITRPLPAVPIYKEKG--LTSVAVANV PLXD1_HUMAN PLXD1_HUMAN VQGTGPACERKL-NIQLQPEQLDCGAAHLQHPLSILQPLKATPVFRAPG--LTSVAVASV Q3UH93_MOUSE Q3UH93_MOUSE VQGTGPACESKR-NIQLQPEQLDCGAAHLQHPLTILQPLRASPVFRAPG--LTAVAVASA Q68HV1_MOUSE Q68HV1_MOUSE VQGTGPACESKR-NIQLQPEQLDCGAAHLQHPLTILQPLRASPVFRAPG--LTAVAVASA Q6ZQ83_MOUSE Q6ZQ83_MOUSE VQGTGPACESKR-NIQLQPEQLDCGAAHLQHPLTILQPLRASPVFRAPG--LTAVAVASA Q3U3W7_MOUSE Q3U3W7_MOUSE ------------------------------------------------------------ B2RXS4_MOUSE B2RXS4_MOUSE KPFHGEIQCGG--HLIGASESFPCGSEHLPYPLGSRDGLVATAVLHRGGLNLTAVTVTAE Q3UH76_MOUSE Q3UH76_MOUSE KPFHGEIQCGG--HLIGASESFPCGSEHLPYPLGSRDGLVATAVLHRGGLNLTAVTVTAE Q5RAK5_PONAB Q5RAK5_PONAB KPFHGEIQCGG--HALGSSKSFPCGSEHLPYPLGSRDGLKATAVLQRGGLNLTAVTVTAE A6QRH2_HUMAN A6QRH2_HUMAN ------------------------------------------------------------ PLXB2_HUMAN PLXB2_HUMAN KPFHGDIQCGG--HAPGSSKSFPCGSEHLPYPLGSRDGLRGTAVLQRGGLNLTAVTVAAE Q3LIB1_HUMAN Q3LIB1_HUMAN ------------------------------------------------------------ Q4T033_TETNG Q4T033_TETNG ------------------------------------------------------------ Q5RH91_DANRE Q5RH91_DANRE ------------------------------------------------------------ A2AFF9_MOUSE A2AFF9_MOUSE VEYGVTSRCVT--LPPDSPESYPCGDEHTPSPIAGRQPLEAQPLLQL-GQSISAVAALQT PLXB3_MOUSE PLXB3_MOUSE VEYGVTSRCVT--LPPDSPESYPCGDEHTPSPIAGRQPLEAQPLLQL-GQSISAVAALQT B7Z3E6_HUMAN B7Z3E6_HUMAN VEYGVTSRCVT--LPLDSPESYPCGDEHTPSPIAGRQPLEVQPLLKL-GQPVSAVAALQA A8K920_HUMAN A8K920_HUMAN VEYGVTSRCVT--LPLDSPESYPCGDEHTPSPIAGRQPLEVQPLLKL-GQPVSAVAALQA B7Z3H9_HUMAN B7Z3H9_HUMAN -------------HFMDSPESYPCGDEHTPSPIAGRQPLEVQPLLKL-GQPVSAVAALQA PLXB3_HUMAN PLXB3_HUMAN VEYGVTSRCVT--LPLDSPESYPCGDEHTPSPIAGRQPLEVQPLLKL-GQPVSAVAALQA B0V3R5_DANRE B0V3R5_DANRE ------------------------------------------------------------ Q4TAV0_TETNG Q4TAV0_TETNG ------------------------------------------------------------ Q4T1S7_TETNG Q4T1S7_TETNG -------------LDPTQPPS-PGPSQHSQIETERRDPIPES------------------ A6H8Y2_HUMAN A6H8Y2_HUMAN IEYDVNSDCAQ--LPVDTLDAYPCGSDHTPSPMASRVPLEATPILEWPGIQLTAVAVTME PLXB1_HUMAN PLXB1_HUMAN IEYDVNSDCAQ--LPVDTLDAYPCGSDHTPSPMASRVPLEATPILEWPGIQLTAVAVTME B2RWT9_MOUSE B2RWT9_MOUSE IAYDVLSDCAQ--LPVDTPDAFPCGSDHTPSPMVSCVPLEATPILELPGVQLTAVAVTME PLXB1_MOUSE PLXB1_MOUSE IAYDVLSDCAQ--LPVDTPDAFPCGSDHTPSPMVSCVPLEATPILELPGVQLTAVAVTME MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RGW1_DANRE Q5RGW1_DANRE GSWIVLFMGNSDGQLIKLVLDENYTPSCPTV-LYKSDDERAVFPRMHFDPVDSKYIYIAL Q4RJU9_TETNG Q4RJU9_TETNG SNSQLTFLAN-------------MTLVNQWT--LKLPAGEAVHHHMTFDPKDSSYLYLMT Q6DSU3_DANRE Q6DSU3_DANRE HNHTLMFLG-SRGRLHKVSLHSNFSVSQQWS--LRLPANEPVHHIMTFDPSDRTYLYVMT B5DE65_XENTR B5DE65_XENTR SGYMVVFLGNVSGHLIKINLDADMKIINKSMQYLEIASGQPVHHVMEFDPMDPTYLFVMT Q0P4P1_XENTR Q0P4P1_XENTR SGYMVVFLGNVSGHLIKINLDADMKIINKSMQYLEIASGQPVHHVMEFDPMDPTYLFVMT PLXD1_HUMAN PLXD1_HUMAN NNYTAVFLGTVNGRLLKINLNESMQVVSRRV--VTVAYGEPVHHVMQFDPADSVYLYLMT Q3UH93_MOUSE Q3UH93_MOUSE NNYTAVFLGTATGRLLKISLNESMQVVSRRV--LTVAYGEPVHHVMQFDPMDPGYLYLMT Q68HV1_MOUSE Q68HV1_MOUSE NNYTAVFLGTATGRLLKISLNESMQVVSRRV--LTVAYGEPVHHVMQFDPMDPGYLYLMT Q6ZQ83_MOUSE Q6ZQ83_MOUSE NNYTAVFLGTATGRLLKISLNESMQVVSRRV--LTVAYGEPVHHVMQFDPMDPGYLYLMT Q3U3W7_MOUSE Q3U3W7_MOUSE ------------------------------------------------------------ B2RXS4_MOUSE B2RXS4_MOUSE NDHTVAFLGTSDGRILKVYLAPDGTSAEYGS--IPVDINKKIKQDLALSG-NLSSLYAMT Q3UH76_MOUSE Q3UH76_MOUSE NDHTVAFLGTSDGRILKVYLAPDGTSAEYGS--IPVDINKKIKQDLALSG-NLSSLYAMT Q5RAK5_PONAB Q5RAK5_PONAB NNHTVAFLGTSDGRILKVYLTPDGTSSEYDS--ILVEINKRVKRDLVLSG-DLASLYTMT A6QRH2_HUMAN A6QRH2_HUMAN ------------------------------------------------------------ PLXB2_HUMAN PLXB2_HUMAN NNHTVAFLGTSDGRILKVYLTPDGTSSEYDS--ILVEINKRVKRDLVLSG-DLGSLYAMT Q3LIB1_HUMAN Q3LIB1_HUMAN ------------------------------------------------------------ Q4T033_TETNG Q4T033_TETNG ------------------------------------------------------------ Q5RH91_DANRE Q5RH91_DANRE ------------------------------------------------------------ A2AFF9_MOUSE A2AFF9_MOUSE DGHTIAFLGDTQGQLHKVFLNSSHGQVYHSQ--QVGPPGSAISPDLLVDS-NGDHLYVLT PLXB3_MOUSE PLXB3_MOUSE DGHTIAFLGDTQGQLHKVFLNSSHGQVYHSQ--QVGPPGSAISPDLLVDS-NGDHLYVLT B7Z3E6_HUMAN B7Z3E6_HUMAN DGHMIAFLGDTQGQLYKVFLHGSQGQVYHSQ--QVGPPGSAISPDLLLDS-SGSHLYVLT A8K920_HUMAN A8K920_HUMAN DGHMIAFLGDTQGQLYKVFLHGSQGQVYHSQ--QVGPPGSAISPDLLLDS-SGSHLYVLT B7Z3H9_HUMAN B7Z3H9_HUMAN DGHMIAFLGDTQGQLYKVFLHGSQGQVYHSQ--QVGPPGSAISPDLLLDS-SGSHLYVLT PLXB3_HUMAN PLXB3_HUMAN DGHMIAFLGDTQGQLYKVFLHGSQGQVYHSQ--QVGPPGSAISPDLLLDS-SGSHLYVLT B0V3R5_DANRE B0V3R5_DANRE ------------------------------------------------------------ Q4TAV0_TETNG Q4TAV0_TETNG ------------------------------------------------------------ Q4T1S7_TETNG Q4T1S7_TETNG --------GNDTASYSAATLLSGDGEIDHTP---------QSYPHLLGHDSDLDYQY--- A6H8Y2_HUMAN A6H8Y2_HUMAN DGHTIAFLGDSQGQLHRVYLGPGSDGHPYST--QSIQQGSAVSRDLTFDG-TFEHLYVMT PLXB1_HUMAN PLXB1_HUMAN DGHTIAFLGDSQGQLHRVYLGPGSDGHPYST--QSIQQGSAVSRDLTFDG-TFEHLYVMT B2RWT9_MOUSE B2RWT9_MOUSE DGHTIAFLGDSQGQLHRVYLGPGRSAAPYSK--QSIQPGSPVNRDLTFDG-TFEHLYVAT PLXB1_MOUSE PLXB1_MOUSE DGHTIAFLGDSQGQLHRVYLGPGRSAAPYSK--QSIQPGSPVNRDLTFDG-TFEHLYVAT MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RGW1_DANRE Q5RGW1_DANRE RKQIRRVSVVRCAKYNTLKDCRSALDPLCGWCVNTQRC---------------------- Q4RJU9_TETNG Q4RJU9_TETNG SHHMLRVKVAQCDQWRSCSDCVGAGDAHCGWCTLENRCSIQKECALGLLTRSWISMAEGP Q6DSU3_DANRE Q6DSU3_DANRE SHHLLRVRVSSCEQYSSCGDCLSAGDPHCGWCTLERRCSVQQDCSSVSLSRSWISISEGV B5DE65_XENTR B5DE65_XENTR SHQMTRVKVAECAKYRSCTECLAAADAYCGWCTLEGRCSLQKECQGSEDSAFWMSPNVGQ Q0P4P1_XENTR Q0P4P1_XENTR SHQMTRVKVAECAKYRSCTECLAAADAYCGWCTLEGRCSLQKECQGSEDSAFWMSPNVGQ PLXD1_HUMAN PLXD1_HUMAN SHQMARVKVAACNVHSTCGDCVGAADAYCGWCALETRCTLQQDCTNSSQQHFWTSASEGP Q3UH93_MOUSE Q3UH93_MOUSE SHQMARVKVAACEVHSTCGDCVGAADAYCGWCTLETRCTLQQDCTNSSQPHFWTSASEGP Q68HV1_MOUSE Q68HV1_MOUSE SHQMARVKVAACEVHSTCGDCVGAADAYCGWCTLETRCTLQQDCTNSSQPHFWTSASEGP Q6ZQ83_MOUSE Q6ZQ83_MOUSE SHQMARVKVAACEVHSTCGDCVGAADAYCGWCTLETRCTLQQDCTNSSQPHFWTSASEGP Q3U3W7_MOUSE Q3U3W7_MOUSE ------------------------------------------------------------ B2RXS4_MOUSE B2RXS4_MOUSE QDKVFRLPVQECLSYVTCAQCRDSQDPYCGWCVIEGRCTRKSECSRAEETGHWLWSREKS Q3UH76_MOUSE Q3UH76_MOUSE QDKVFRLPVQECLSYVTCAQCRDSQDPYCGWCVIEGRCTRKSECSRAEETGHWLWSREKS Q5RAK5_PONAB Q5RAK5_PONAB QDKVFRLPVQECLSYPTCTQCRDSQDPYCGWCVVEGRCTRKAECLRAEEASHWLWSRSKS A6QRH2_HUMAN A6QRH2_HUMAN ------------------------------------------------------------ PLXB2_HUMAN PLXB2_HUMAN QDKVFRLPVQECLSYPTCTQCRDSQDPYCGWCVVEGRCTRKAECPRAEEASHWLWSRSKS Q3LIB1_HUMAN Q3LIB1_HUMAN ------------------------------------------------------------ Q4T033_TETNG Q4T033_TETNG ------------------------------------------------------------ Q5RH91_DANRE Q5RH91_DANRE ------------------------------------------------------------ A2AFF9_MOUSE A2AFF9_MOUSE AQQVDRILVAACPQFPNCTTCLQARDPLCGWCILQGRCTRRGECGRAAQPNHWLWSYEDN PLXB3_MOUSE PLXB3_MOUSE AQQVDRILVAACPQFPNCTTCLQARDPLCGWCILQGRCTRRGECGRAAQPNHWLWSYEDN B7Z3E6_HUMAN B7Z3E6_HUMAN AHQVDRIPVAACPQFPDCASCLQAQDPLCGWCVLQGRCTRKGQCGRAGQLNQWLWSYEED A8K920_HUMAN A8K920_HUMAN AHQVDRIPVAACPQFPDCASCLQAQDPLCGWCVLQGRCTRKGQCGRAGQLNQWLWSYEED B7Z3H9_HUMAN B7Z3H9_HUMAN AHQVDRIPVAACPQFPDCASCLQAQDPLCGWCVLQGRCTRKGQCGRAGQLNQWLWSYEED PLXB3_HUMAN PLXB3_HUMAN AHQVDRIPVAACPQFPDCASCLQAQDPLCGWCVLQGRCTRKGQCGRAGQLNQWLWSYEED B0V3R5_DANRE B0V3R5_DANRE ------------------------------------------------------------ Q4TAV0_TETNG Q4TAV0_TETNG ------------------------------------------------------------ Q4T1S7_TETNG Q4T1S7_TETNG -------------------------DPADGF----------------------------- A6H8Y2_HUMAN A6H8Y2_HUMAN QSTLLKVPVASCAQHLDCASCLAHRDPYCGWCVLLGRCSRRSECSRGQGPEQWLWSFQPE PLXB1_HUMAN PLXB1_HUMAN QSTLLKVPVASCAQHLDCASCLAHRDPYCGWCVLLGRCSRRSECSRGQGPEQWLWSFQPE B2RWT9_MOUSE B2RWT9_MOUSE QTTLVKVPVAPCAQHLDCDSCLAHRDPYCGWCVLLGRCSRRSECSRDQGPEQWLWSFQPE PLXB1_MOUSE PLXB1_MOUSE QTTLVKVPVAPCAQHLDCDSCLAHRDPYCGWCVLLGRCSRRSECSRDQGPEQWLWSFQPE MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RGW1_DANRE Q5RGW1_DANRE ------------------------------------------------------------ Q4RJU9_TETNG Q4RJU9_TETNG QQ-CPSMTLTPPEISVSADIKDVGILINGSVPDLLGSRVECEYRPGVSTSATVHLDSGPA Q6DSU3_DANRE Q6DSU3_DANRE QQ-CPSMTITPAEISRSAEMRDVGILVAGSVPDLQGLRVECDYGMGISTNATVHLDYGTS B5DE65_XENTR B5DE65_XENTR ENMCPAMNSIPNKIDISSSTQRIILQITGKLPILYQMNVSCDYGNNIITPAVIDPDQDSG Q0P4P1_XENTR Q0P4P1_XENTR ENMCPAMNSIPNKIDISSSTQRIILQITGKLPILYQMNVSCDYGNNIITPAVIDPDQDSG PLXD1_HUMAN PLXD1_HUMAN SR-CPAMTVLPSEIDVRQEYPGMILQISGSLPSLSGMEMACDYGNNIRTVARVPGPAFGH Q3UH93_MOUSE Q3UH93_MOUSE SR-CPAMTVLPSEIDVHRDYTGMILQISGSLPSLSGMEMACDYGNGVRTVARVPGPAYDH Q68HV1_MOUSE Q68HV1_MOUSE SR-CPAMTVLPSEIDVHRDYTGMILQISGSLPSLSGMEMACDYGNGVRTVARVPGPAYDH Q6ZQ83_MOUSE Q6ZQ83_MOUSE SR-CPAMTVLPSEIDVHRDYTGMILQISGSLPSLSGMEMACDYGNGVRTVARVPGPAYDH Q3U3W7_MOUSE Q3U3W7_MOUSE ------------------------------------------------------------ B2RXS4_MOUSE B2RXS4_MOUSE ---CVAITDAFPQNMSRRAQGEVRLSVSPLPTLTEDDELLCLFGDSPPHPARVEDDT--- Q3UH76_MOUSE Q3UH76_MOUSE ---CVAITDAFPQNMSRRAQGEVRLSVSPLPTLTEDDELLCLFGDSPPHPARVEDDT--- Q5RAK5_PONAB Q5RAK5_PONAB ---CVAITSAQPQNMSRRAQGEVQLTVSPLPALSEEDELLCLFGESPPHPARVEGEA--- A6QRH2_HUMAN A6QRH2_HUMAN ------------------------------------------------------------ PLXB2_HUMAN PLXB2_HUMAN ---CVAVTSAQPQNMSRRAQGEVQLTVSPLPALSEEDELLCLFGESPPHPARVEGEA--- Q3LIB1_HUMAN Q3LIB1_HUMAN ------------------------------------------------------------ Q4T033_TETNG Q4T033_TETNG ------------------------------------------------------------ Q5RH91_DANRE Q5RH91_DANRE ------------------------------------------------------------ A2AFF9_MOUSE A2AFF9_MOUSE H--CPYIQSLLPAQHPRQEQGQIILSVPRLPTLAMDEYFHCAFGGY-NSLAQVEEPH--- PLXB3_MOUSE PLXB3_MOUSE H--CPYIQSLLPAQHPRQEQGQIILSVPRLPTLAMDEYFHCAFGGY-NSLAQVEEPH--- B7Z3E6_HUMAN B7Z3E6_HUMAN SH-CLHIQSLLPGHHPRQEQGQVTLSVPRLPILDADEYFHCAFGDY-DSLAHVEGPH--- A8K920_HUMAN A8K920_HUMAN SH-CLHIQSLLPGHHPRQEQGQVTLSVPRLPILDADEYFHCAFGDY-DSLAHVEGPH--- B7Z3H9_HUMAN B7Z3H9_HUMAN SH-CLHIQSLLPGHHPRQEQGQVTLSVPRLPILDADEYFHCAFGDY-DSLAHVEGPH--- PLXB3_HUMAN PLXB3_HUMAN SH-CLHIQSLLPGHHPRQEQGQVTLSVPRLPILDADEYFHCAFGDY-DSLAHVEGPH--- B0V3R5_DANRE B0V3R5_DANRE ------------------------------------------------------------ Q4TAV0_TETNG Q4TAV0_TETNG ------------------------------------------------------------ Q4T1S7_TETNG Q4T1S7_TETNG --------------------------------LPGDEGSFVSWGSS-------------- A6H8Y2_HUMAN A6H8Y2_HUMAN LG-CLQVAAMSPANISREETREVFLSVPDLPPLWPGESYSCHFGEH-QSPALLTGSG--- PLXB1_HUMAN PLXB1_HUMAN LG-CLQVAAMSPANISREETREVFLSVPDLPPLWPGESYSCHFGEH-QSPALLTGSG--- B2RWT9_MOUSE B2RWT9_MOUSE LG-CLRVVAVSPANISREERREVFLSVPGLPSLWPGESYFCYFGDQ-QSPALLTSSG--- PLXB1_MOUSE PLXB1_MOUSE LG-CLRVVAVSPANISREERREVFLSVPGLPSLWPGESYFCYFGDQ-QSPALLTSSG--- MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RGW1_DANRE Q5RGW1_DANRE --VQCISS---------------------------------------------------- Q4RJU9_TETNG Q4RJU9_TETNG QIQTCPLLPRENYQSIPPGSDH--QAVSVAIKVNGTSVVSGSFILYDCERTGAIHPKTSC Q6DSU3_DANRE Q6DSU3_DANRE HIQTCPLPPAHTLPTIPSGTDH--VTVPVSINANGVSVVSGRFIIYDCERTGQIHSTTAC B5DE65_XENTR B5DE65_XENTR QLLHCSFLPRDQFPSFPPNQDY--VTVSMALSVGGNSIIQHKFIIYDCNRTQNMHPKNAC Q0P4P1_XENTR Q0P4P1_XENTR QLLHCSFLPRDQFPSFPPNQDY--VTVSMALSVGGNSIIQHKFIIYDCNRTQNMHPKNAC PLXD1_HUMAN PLXD1_HUMAN QIAYCNLLPRDQFPPFPPNQDH--VTVEMSVRVNGRNIVKANFTIYDCSRTAQVYPHTAC Q3UH93_MOUSE Q3UH93_MOUSE QIAYCNLLPRAQFPSFPAGQDH--VTVEMSVRVKGHNIVSANFTIYDCSRIGQVYPHTAC Q68HV1_MOUSE Q68HV1_MOUSE QIAYCNLLPRAQFPSFPAGQDH--VTVEMSVRVKGHNIVSANFTIYDCSRIGQVYPHTAC Q6ZQ83_MOUSE Q6ZQ83_MOUSE QIAYCNLLPRAQFPSFPAGQDH--VTVEMSVRVKGHNIVSANFTIYDCSRIGQVYPHTAC Q3U3W7_MOUSE Q3U3W7_MOUSE ------------------------------------------------------------ B2RXS4_MOUSE B2RXS4_MOUSE --VICNSP--SSIPSTPPGQDHVDVSIQLLLKSGSVFLTSHQYPFYDCREAMSLVENLPC Q3UH76_MOUSE Q3UH76_MOUSE --VICNSP--SSIPSTPPGQDHVDVSIQLLLKSGSVFLTSHQYPFYDCREAMSLVENLPC Q5RAK5_PONAB Q5RAK5_PONAB --VICNSP--SSIPVTPPGQDHVAVTIQLLLRRGNIFLTSYQYPFYDCRQAMSLEENLPC A6QRH2_HUMAN A6QRH2_HUMAN ------------------------------------------------------------ PLXB2_HUMAN PLXB2_HUMAN --VICNSP--SSIPVTPPGQDHVAVTIQLLLRRGNIFLTSYQYPFYDCRQAMSLEENLPC Q3LIB1_HUMAN Q3LIB1_HUMAN ------------------------------------------------------------ Q4T033_TETNG Q4T033_TETNG ------------------------------------------------------------ Q5RH91_DANRE Q5RH91_DANRE ------------------------------------------------------------ A2AFF9_MOUSE A2AFF9_MOUSE --VVCTTPPQDQMPPNPPGSDH--VTLPLALMFEDVVLTATTFSFYDCSAVQALEVAAPC PLXB3_MOUSE PLXB3_MOUSE --VVCTTPPQDQMPPNPPGSDH--VTLPLALMFEDVVLTATTFSFYDCSAVQALEVAAPC B7Z3E6_HUMAN B7Z3E6_HUMAN --VACVTPPQDQVPLNPPGTDH--ITVPLALMFEDVTVAATNFSFYDCSAVQALEAAAPC A8K920_HUMAN A8K920_HUMAN --VACVTPPQDQVPLNPPGTDH--ITVPLALMFEDVTVAATNFSFYDCSAVQALEAAAPC B7Z3H9_HUMAN B7Z3H9_HUMAN --VACVTPPQDQVPLNPPGTDH--VTVPLALMFEDVTVAATNFSFYDCSAVQALEAAAPC PLXB3_HUMAN PLXB3_HUMAN --VACVTPPQDQVPLNPPGTDH--VTVPLALMFEDVTVAATNFSFYDCSAVQALEAAAPC B0V3R5_DANRE B0V3R5_DANRE ------------------------------------------------------------ Q4TAV0_TETNG Q4TAV0_TETNG ------------------------------------------------------------ Q4T1S7_TETNG Q4T1S7_TETNG ------------------------------------------------------------ A6H8Y2_HUMAN A6H8Y2_HUMAN --VMCPSPDPSEAPVLPRGADY--VSVSVELRFGAVVIAKTSLSFYDCVAVTELRPSAQC PLXB1_HUMAN PLXB1_HUMAN --VMCPSPDPSEAPVLPRGADY--VSVSVELRFGAVVIAKTSLSFYDCVAVTELRPSAQC B2RWT9_MOUSE B2RWT9_MOUSE --VMCPSPDPSEAPVLQRGADH--ISVNVELRFGAVVIASTSLSFYDCVAVTASSPSAPC PLXB1_MOUSE PLXB1_MOUSE --VMCPSPDPSEAPVLQRGADH--ISVNVELRFGAVVIASTSLSFYDCVAVTASSPSAPC MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RGW1_DANRE Q5RGW1_DANRE --------GCHW------------------------------------------------ Q4RJU9_TETNG Q4RJU9_TETNG VSCLSARWKCYWDQENHLCVSNKDESNLNLIEIN--R----------------------- Q6DSU3_DANRE Q6DSU3_DANRE TSCLSSAWRCFWDPQLHQCVSSKNN----------------------------------- B5DE65_XENTR B5DE65_XENTR TSCVKSRWPCSWCVSQHRCVSSASQ-----------C----------------------- Q0P4P1_XENTR Q0P4P1_XENTR TSCVKSRWPCSWCVSQHRCVSSASQ-----------C----------------------- PLXD1_HUMAN PLXD1_HUMAN TSCLSAQWPCFWCSQQHSCVSNQSR-----------C----------------------- Q3UH93_MOUSE Q3UH93_MOUSE TSCLSTQWPCSWCIQLHSCVSNQSQ-----------C----------------------- Q68HV1_MOUSE Q68HV1_MOUSE TSCLSTQWPCSWCIQLHSCVSNQSQ-----------C----------------------- Q6ZQ83_MOUSE Q6ZQ83_MOUSE TSCLSTQWPCSWCIQLHSCVSNQSQ-----------C----------------------- Q3U3W7_MOUSE Q3U3W7_MOUSE ------------------------------------------------------------ B2RXS4_MOUSE B2RXS4_MOUSE ISCASNRWTCQWDLQYYECREASPN----------PE----------------------- Q3UH76_MOUSE Q3UH76_MOUSE ISCASNRWTCQWDLQYYECREASPN----------PE----------------------- Q5RAK5_PONAB Q5RAK5_PONAB ISCVSNRWTCQWDLRYHECREASPN---------P-E----------------------- A6QRH2_HUMAN A6QRH2_HUMAN ----------QWDLRYHECREASPN---------P-E----------------------- PLXB2_HUMAN PLXB2_HUMAN ISCVSNRWTCQWDLRYHECREASPN----------PE----------------------- Q3LIB1_HUMAN Q3LIB1_HUMAN ------------------------------------------------------------ Q4T033_TETNG Q4T033_TETNG ------------------------------------------------------------ Q5RH91_DANRE Q5RH91_DANRE ------------------------------------------------------------ A2AFF9_MOUSE A2AFF9_MOUSE RACVSSLWRCHWCPQSSHCIYGEHC-----------P----------------------- PLXB3_MOUSE PLXB3_MOUSE RACVSSLWRCHWCPQSSHCIYGEHC-----------P----------------------- B7Z3E6_HUMAN B7Z3E6_HUMAN RACVGSIWRCHWCPQSSHCVYGEHC-----------P----------------------- A8K920_HUMAN A8K920_HUMAN RACVGSIWRCHWCPQSSHCVYGEHC-----------P----------------------- B7Z3H9_HUMAN B7Z3H9_HUMAN RACVGSIWRCHWCPQSSHCVYGEHC-----------P----------------------- PLXB3_HUMAN PLXB3_HUMAN RACVGSIWRCHWCPQSSHCVYGEHC-----------P----------------------- B0V3R5_DANRE B0V3R5_DANRE ------------------------------------------------------------ Q4TAV0_TETNG Q4TAV0_TETNG ------------------------------------------------------------ Q4T1S7_TETNG Q4T1S7_TETNG ------------------------------------------------------------ A6H8Y2_HUMAN A6H8Y2_HUMAN QACVSSRWGCNWCVWQHLCTHKASCDAGPMVASHQSPLVSPDPPARGGPSPSPPTAPKAL PLXB1_HUMAN PLXB1_HUMAN QACVSSRWGCNWCVWQHLCTHKASCDAGPMVASHQSPLVSPDPPARGGPSPSPPTAPKAL B2RWT9_MOUSE B2RWT9_MOUSE RACVSSRWGCNWCVWQQLCTHKASCDAGPMVASQQSPLLPLIPPARDELTPFPPTVPQTT PLXB1_MOUSE PLXB1_MOUSE RACVSSRWGCNWCVWQQLCTHKASCDAGPMVASQQSPLLPLIPPARDELTPFPPTVPQTT MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RGW1_DANRE Q5RGW1_DANRE ------------------------------------------------------------ Q4RJU9_TETNG Q4RJU9_TETNG ------------------------------------------------------------ Q6DSU3_DANRE Q6DSU3_DANRE ------------------------------------------------------------ B5DE65_XENTR B5DE65_XENTR ------------------------------------------------------------ Q0P4P1_XENTR Q0P4P1_XENTR ------------------------------------------------------------ PLXD1_HUMAN PLXD1_HUMAN ------------------------------------------------------------ Q3UH93_MOUSE Q3UH93_MOUSE ------------------------------------------------------------ Q68HV1_MOUSE Q68HV1_MOUSE ------------------------------------------------------------ Q6ZQ83_MOUSE Q6ZQ83_MOUSE ------------------------------------------------------------ Q3U3W7_MOUSE Q3U3W7_MOUSE ------------------------------------------------------------ B2RXS4_MOUSE B2RXS4_MOUSE ------------------------------------------------------------ Q3UH76_MOUSE Q3UH76_MOUSE ------------------------------------------------------------ Q5RAK5_PONAB Q5RAK5_PONAB ------------------------------------------------------------ A6QRH2_HUMAN A6QRH2_HUMAN ------------------------------------------------------------ PLXB2_HUMAN PLXB2_HUMAN ------------------------------------------------------------ Q3LIB1_HUMAN Q3LIB1_HUMAN ------------------------------------------------------------ Q4T033_TETNG Q4T033_TETNG ------------------------------------------------------------ Q5RH91_DANRE Q5RH91_DANRE ------------------------------------------------------------ A2AFF9_MOUSE A2AFF9_MOUSE ------------------------------------------------------------ PLXB3_MOUSE PLXB3_MOUSE ------------------------------------------------------------ B7Z3E6_HUMAN B7Z3E6_HUMAN ------------------------------------------------------------ A8K920_HUMAN A8K920_HUMAN ------------------------------------------------------------ B7Z3H9_HUMAN B7Z3H9_HUMAN ------------------------------------------------------------ PLXB3_HUMAN PLXB3_HUMAN ------------------------------------------------------------ B0V3R5_DANRE B0V3R5_DANRE ------------------------------------------------------------ Q4TAV0_TETNG Q4TAV0_TETNG ------------------------------------------------------------ Q4T1S7_TETNG Q4T1S7_TETNG ------------------------------------------------------------ A6H8Y2_HUMAN A6H8Y2_HUMAN ATPAPDTLPVEPGAPSTATASDISPGASPSLLSPWGPWAGSGSISSPGSTGSPLHEEPSP PLXB1_HUMAN PLXB1_HUMAN ATPAPDTLPVEPGAPSTATASDISPGASPSLLSPWGPWAGSGSISSPGSTGSPLHEEPSP B2RWT9_MOUSE B2RWT9_MOUSE VTPTPNSFPIEPRAPS--TASDVLPGAKPSRLSLWGPWAGPGPILSPTSTESPLHEKPLP PLXB1_MOUSE PLXB1_MOUSE VTPTPNSFPIEPRAPS--TASDVLPGAKPSRLSLWGPWAGPGPILSPTSTESPLHEKPLP MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RGW1_DANRE Q5RGW1_DANRE ------------------------------------------------------------ Q4RJU9_TETNG Q4RJU9_TETNG ------------------------------------------------------------ Q6DSU3_DANRE Q6DSU3_DANRE ------------------------------------------------------------ B5DE65_XENTR B5DE65_XENTR ------------------------------------------------------------ Q0P4P1_XENTR Q0P4P1_XENTR ------------------------------------------------------------ PLXD1_HUMAN PLXD1_HUMAN ------------------------------------------------------------ Q3UH93_MOUSE Q3UH93_MOUSE ------------------------------------------------------------ Q68HV1_MOUSE Q68HV1_MOUSE ------------------------------------------------------------ Q6ZQ83_MOUSE Q6ZQ83_MOUSE ------------------------------------------------------------ Q3U3W7_MOUSE Q3U3W7_MOUSE ------------------------------------------------------------ B2RXS4_MOUSE B2RXS4_MOUSE ------------------------------------------------------------ Q3UH76_MOUSE Q3UH76_MOUSE ------------------------------------------------------------ Q5RAK5_PONAB Q5RAK5_PONAB ------------------------------------------------------------ A6QRH2_HUMAN A6QRH2_HUMAN ------------------------------------------------------------ PLXB2_HUMAN PLXB2_HUMAN ------------------------------------------------------------ Q3LIB1_HUMAN Q3LIB1_HUMAN ------------------------------------------------------------ Q4T033_TETNG Q4T033_TETNG ------------------------------------------------------------ Q5RH91_DANRE Q5RH91_DANRE ------------------------------------------------------------ A2AFF9_MOUSE A2AFF9_MOUSE ------------------------------------------------------------ PLXB3_MOUSE PLXB3_MOUSE ------------------------------------------------------------ B7Z3E6_HUMAN B7Z3E6_HUMAN ------------------------------------------------------------ A8K920_HUMAN A8K920_HUMAN ------------------------------------------------------------ B7Z3H9_HUMAN B7Z3H9_HUMAN ------------------------------------------------------------ PLXB3_HUMAN PLXB3_HUMAN ------------------------------------------------------------ B0V3R5_DANRE B0V3R5_DANRE ------------------------------------------------------------ Q4TAV0_TETNG Q4TAV0_TETNG ------------------------------------------------------------ Q4T1S7_TETNG Q4T1S7_TETNG ------------------------------------------------------------ A6H8Y2_HUMAN A6H8Y2_HUMAN PSPQNGPGTAVPAPTDFRPSATPEDLLASPLSPSEVAAVPPADPGPEALHPTVPLDLPPA PLXB1_HUMAN PLXB1_HUMAN PSPQNGPGTAVPAPTDFRPSATPEDLLASPLSPSEVAAVPPADPGPEALHPTVPLDLPPA B2RWT9_MOUSE B2RWT9_MOUSE PDPPTIPGTTVPAPTGLGPSTTPEDLLASYPFPSDAAAVSPAEPGPEALPSMVALDQPPG PLXB1_MOUSE PLXB1_MOUSE PDPPTIPGTTVPAPTGLGPSTTPEDLLASYPFPSDAAAVSPAEPGPEALPSMVALDQPPG MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RGW1_DANRE Q5RGW1_DANRE ------------------------------------------------------------ Q4RJU9_TETNG Q4RJU9_TETNG --------------------------------------------------TGISAFADVC Q6DSU3_DANRE Q6DSU3_DANRE ------------------------------------------------------------ B5DE65_XENTR B5DE65_XENTR --------------------------------------------------DTIAQ----- Q0P4P1_XENTR Q0P4P1_XENTR --------------------------------------------------DTIAQ----- PLXD1_HUMAN PLXD1_HUMAN --------------------------------------------------EASPNP---- Q3UH93_MOUSE Q3UH93_MOUSE --------------------------------------------------QDSPNP---- Q68HV1_MOUSE Q68HV1_MOUSE --------------------------------------------------QDSPNP---- Q6ZQ83_MOUSE Q6ZQ83_MOUSE --------------------------------------------------QDSPNP---- Q3U3W7_MOUSE Q3U3W7_MOUSE ------------------------------------------------------------ B2RXS4_MOUSE B2RXS4_MOUSE --------------------------------------------------EGIIRA---- Q3UH76_MOUSE Q3UH76_MOUSE --------------------------------------------------EGIIRA---- Q5RAK5_PONAB Q5RAK5_PONAB --------------------------------------------------DGIVRA---- A6QRH2_HUMAN A6QRH2_HUMAN --------------------------------------------------DGIVRA---- PLXB2_HUMAN PLXB2_HUMAN --------------------------------------------------DGIVRA---- Q3LIB1_HUMAN Q3LIB1_HUMAN ------------------------------------------------------------ Q4T033_TETNG Q4T033_TETNG ------------------------------------------------------------ Q5RH91_DANRE Q5RH91_DANRE ------------------------------------------------------------ A2AFF9_MOUSE A2AFF9_MOUSE --------------------------------------------------EGEKAVYSAQ PLXB3_MOUSE PLXB3_MOUSE --------------------------------------------------EGEKAVYSAQ B7Z3E6_HUMAN B7Z3E6_HUMAN --------------------------------------------------EGERTIYSAQ A8K920_HUMAN A8K920_HUMAN --------------------------------------------------EGERTIYSAQ B7Z3H9_HUMAN B7Z3H9_HUMAN --------------------------------------------------EGERTIYSAQ PLXB3_HUMAN PLXB3_HUMAN --------------------------------------------------EGERTIYSAQ B0V3R5_DANRE B0V3R5_DANRE ------------------------------------------------------------ Q4TAV0_TETNG Q4TAV0_TETNG ------------------------------------------------------------ Q4T1S7_TETNG Q4T1S7_TETNG ------------------------------------------------------------ A6H8Y2_HUMAN A6H8Y2_HUMAN TVPATTFPGAMGSVKPALDWLTREGGELPEADEWTGGDAPAFSTSTLLSGDGDSAELEGP PLXB1_HUMAN PLXB1_HUMAN TVPATTFPGAMGSVKPALDWLTREGGELPEADEWTGGDAPAFSTSTLLSGDGDSAELEGP B2RWT9_MOUSE B2RWT9_MOUSE TVPDTTFPGAPGSMKPVLDWLTKGGGELPEADEWMGGDTPAFSTSTLLSGDGDSAEHEGP PLXB1_MOUSE PLXB1_MOUSE TVPDTTFPGAPGSMKPVLDWLTKGGGELPEADEWMGGDTPAFSTSTLLSGDGDSAEHEGP MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RGW1_DANRE Q5RGW1_DANRE ------------------------------------------------------------ Q4RJU9_TETNG Q4RJU9_TETNG RGAIVFLKLVCHVLSPHPSSP-----QSAASCPSLLA-SDVPPAPSGTAQDFTLSLRNVQ Q6DSU3_DANRE Q6DSU3_DANRE ---------------------TQQLLQNSSSCPSMVAYEVP-PLPTGSSPVFSLELKNVE B5DE65_XENTR B5DE65_XENTR --------------------------NSTESCPRITA-TSLTPTPTGVTKDYTLSLLNTN Q0P4P1_XENTR Q0P4P1_XENTR --------------------------NSTESCPRITA-TSLTPTPTGVTKDYTLSLLNTN PLXD1_HUMAN PLXD1_HUMAN --------------------------TSPQDCPRTL-LSPLAPVPTGGSQNILVPLANTA Q3UH93_MOUSE Q3UH93_MOUSE --------------------------TSPQDCPQILP-SPLAPVPTGGSQDILVPLTKAT Q68HV1_MOUSE Q68HV1_MOUSE --------------------------TSPQDCPQILP-SPLAPVPTGGSQDILVPLTKAT Q6ZQ83_MOUSE Q6ZQ83_MOUSE --------------------------TSPQDCPQILP-SPLAPVPTGGSQDILVPLTKAT Q3U3W7_MOUSE Q3U3W7_MOUSE ------------------------------------------------------------ B2RXS4_MOUSE B2RXS4_MOUSE --------------------------HMEDNCPQFLA-PDPLVIPMNHETEVTFQGKNLE Q3UH76_MOUSE Q3UH76_MOUSE --------------------------HMEDNCPQFLA-PDPLVIPMNHETEVTFQGKNLE Q5RAK5_PONAB Q5RAK5_PONAB --------------------------HMEDSCPQFLG-PSPLVIPMNHETDVTFQGKNLD A6QRH2_HUMAN A6QRH2_HUMAN --------------------------HMEDSCPQFLG-PSPLVIPMNHETDVNFQGKNLD PLXB2_HUMAN PLXB2_HUMAN --------------------------HMEDSCPQFLG-PSPLVIPMNHETDVNFQGKNLD Q3LIB1_HUMAN Q3LIB1_HUMAN ------------------------------------------------------------ Q4T033_TETNG Q4T033_TETNG ------------------------------------------------------------ Q5RH91_DANRE Q5RH91_DANRE ------------------------------------------------------------ A2AFF9_MOUSE A2AFF9_MOUSE EVDILV--------------------RGPEACPQVEGLASPQLVPVGWESHVTLHIQNLH PLXB3_MOUSE PLXB3_MOUSE EVDILV--------------------RGPEACPQVEGLASPQLVPVGWESHVTLHIQNLH B7Z3E6_HUMAN B7Z3E6_HUMAN EVDIQV--------------------RGPGACPQVEGLAGPHLVPVGWESHLALRVRNLQ A8K920_HUMAN A8K920_HUMAN EVDIQV--------------------RGLGACPQVEGLAGPHLVPVGWESHLALRVRNLQ B7Z3H9_HUMAN B7Z3H9_HUMAN EVDIQV--------------------RGPGACPQVEGLAGPHLVPVGWESHLALRVRNLQ PLXB3_HUMAN PLXB3_HUMAN EVDIQV--------------------RGPGACPQVEGLAGPHLVPVGWESHLALRVRNLQ B0V3R5_DANRE B0V3R5_DANRE ------------------------------------------------------------ Q4TAV0_TETNG Q4TAV0_TETNG ------------------------------------------------------------ Q4T1S7_TETNG Q4T1S7_TETNG ------------------------------ACPCVEKVQGSSLLPVGVERKITLLAQNLH A6H8Y2_HUMAN A6H8Y2_HUMAN PAPLILPSSLDYQYDTPGLWELEEATLGASSCPCVESVQGSTLMPVHVEREIRLLGRNLH PLXB1_HUMAN PLXB1_HUMAN PAPLILPSSLDYQYDTPGLWELEEATLGASSCPCVESVQGSTLMPVHVEREIRLLGRNLH B2RWT9_MOUSE B2RWT9_MOUSE PAPLILLSSLDYQYDTPGLWELGEVNQRVSSCPCVETVQGSLLIPVHVEREVQLRGRNLW PLXB1_MOUSE PLXB1_MOUSE PAPLILLSSLDYQYDTPGLWELGEVNQRVSSCPCVETVQGSLLIPVHVEREVQLRGRNLW MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RGW1_DANRE Q5RGW1_DANRE ------------------------------------------------------------ Q4RJU9_TETNG Q4RJU9_TETNG EICKGLISMCMWKSFTIIFAQQGEELECDFGTEQRYEVTWVNSSVVKCSGITLSTNH--- Q6DSU3_DANRE Q6DSU3_DANRE ----------H-----------GTALECVYSDGQQYRAQWLDGPWVNCSGATLK------ B5DE65_XENTR B5DE65_XENTR ----------ITE---------GPKLECDFGTEQTFPAKWLNSSAVVCSNVLLH------ Q0P4P1_XENTR Q0P4P1_XENTR ----------ITE---------GPKLECDFGTEQTFPAKWLNSSAVVCSNVLL------- PLXD1_HUMAN PLXD1_HUMAN ----------FFQ---------GAALECSFGLEEIFEAVWVNESVVRCDQVVLH------ Q3UH93_MOUSE Q3UH93_MOUSE ----------FFH---------GSSLECSFGLEESFEAVWANNSLVRCNQVVLH------ Q68HV1_MOUSE Q68HV1_MOUSE ----------FFH---------GSSLECSFGLEESFEAVWANNSLVRCNQVVLH------ Q6ZQ83_MOUSE Q6ZQ83_MOUSE ----------FFH---------GSSLECSFGLEESFEAVWANNSLVRCNQVVLH------ Q3U3W7_MOUSE Q3U3W7_MOUSE ------------------------------------------------------------ B2RXS4_MOUSE B2RXS4_MOUSE ----------TVK---------VSSLYVGSELLNFEETVTMHESDTFSFRTPKL------ Q3UH76_MOUSE Q3UH76_MOUSE ----------TVK---------VSSLYVGSELLNFEETVTMHESDTFSFRTPKL------ Q5RAK5_PONAB Q5RAK5_PONAB ----------TVK---------GFSLHVGSDLLKFMEPVSMQESGTFVFRTPKL------ A6QRH2_HUMAN A6QRH2_HUMAN ----------TVK---------GSSLHVGSDLLKFMEPVTMQESGTFAFRTPKL------ PLXB2_HUMAN PLXB2_HUMAN ----------TVK---------GSSLHVGSDLLKFMEPVTMQESGTFAFRTPKL------ Q3LIB1_HUMAN Q3LIB1_HUMAN ------------------------------------------------------------ Q4T033_TETNG Q4T033_TETNG ------------------------------------------------------------ Q5RH91_DANRE Q5RH91_DANRE ------------------------------------------------------------ A2AFF9_MOUSE A2AFF9_MOUSE ----------YFQ---------GLPALYHCWLELPGKLQKLPASLEETSRDSGL---IHC PLXB3_MOUSE PLXB3_MOUSE ----------YFQ---------GLPALYHCWLELPGKLQKLPASLEETSRDSGL---IHC B7Z3E6_HUMAN B7Z3E6_HUMAN ----------HFR---------GLPASFHCWLELPGELRGLPATLEETAGDSGL---IHC A8K920_HUMAN A8K920_HUMAN ----------HFR---------GLPASFHCWLELPGELRGLPATLEETAGDSGL---IHC B7Z3H9_HUMAN B7Z3H9_HUMAN ----------HFR---------GLPASFHCWLELPGELRGLPATLEETAGDSGL---IHC PLXB3_HUMAN PLXB3_HUMAN ----------HFR---------GLPASFHCWLELPGELRGLPATLEETAGDSGL---IHC B0V3R5_DANRE B0V3R5_DANRE ------------------------------------------------------------ Q4TAV0_TETNG Q4TAV0_TETNG ------------------------------------------------------------ Q4T1S7_TETNG Q4T1S7_TETNG ----------LYQVHTHAHTHWDRGGEMHSLKVLGLSIPGFFVTNLLTRDSLSSSCESLS A6H8Y2_HUMAN A6H8Y2_HUMAN ----------LFQ---------DGPGDNECVMELEG-LEVVVEARVECEPPPDTQCHVTC PLXB1_HUMAN PLXB1_HUMAN ----------LFQ---------DGPGDNECVMELEG-LEVVVEARVECEPPPDTQCHVTC B2RWT9_MOUSE B2RWT9_MOUSE ----------LFQ---------DGPRSSECVLEL-GSREVAVEAQVECAPPPDVWCHIKC PLXB1_MOUSE PLXB1_MOUSE ----------LFQ---------DGPRSSECVLEL-GSREVAVEAQVECAPPPDVWCHIKC MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RGW1_DANRE Q5RGW1_DANRE ---------------------------------------------------------SSS Q4RJU9_TETNG Q4RJU9_TETNG -------KSQIFHLNLRRKRFYSGRGEDIFVDSPQPVKVEVYNCKVGSSDCSQCWGREDQ Q6DSU3_DANRE Q6DSU3_DANRE ----------TTQWSESFSLNLRRAGDATYIDNPQRMTVEVYSCSAGVSDCSQCLGRAAL B5DE65_XENTR B5DE65_XENTR --------TSERTQSFPINLQLSD-HKGLYLDNPSMLSVEVYNCASQTPDCSSCLGRADL Q0P4P1_XENTR Q0P4P1_XENTR -------YTSERTQSFPINLQLSD-HKGLYLDNPSMLSVEVYNCASQTPDCSSCLGRADL PLXD1_HUMAN PLXD1_HUMAN --------TTRKSQVFPLSLQLKG-RPARFLDSPEPMTVMVYNCAMGSPDCSQCLGREDL Q3UH93_MOUSE Q3UH93_MOUSE --------TTQKSQVFPLSLKLKG-PPDRFLDSPNPMTVVVYNCAMGSPDCSQCLGREDL Q68HV1_MOUSE Q68HV1_MOUSE --------TTQKSQVFPLSLKLKG-PPDRFLDSPNPMTVVVYNCAMGSPDCSQCLGREDL Q6ZQ83_MOUSE Q6ZQ83_MOUSE --------TTQKSQVFPLSLKLKG-PPDRFLDSPNPMTVVVYNCAMGSPDCSQCLGREDL Q3U3W7_MOUSE Q3U3W7_MOUSE ------------------------------------------------------------ B2RXS4_MOUSE B2RXS4_MOUSE --------SHDGNETLPLHLYVKS----FGKNIDSKLQVTLYNCSFGRSDCSLCLA-ADP Q3UH76_MOUSE Q3UH76_MOUSE --------SHDGNETLPLHLYVKS----FGKNIDSKLQVTLYNCSFGRSDCSLCLA-ADP Q5RAK5_PONAB Q5RAK5_PONAB --------SHDANETLPLHLYVK----SYGKNIDSKLHVTLYSCSFGRSDCSLCRA-ANP A6QRH2_HUMAN A6QRH2_HUMAN --------SHDANETLPLHLYVK----SYGKNIDSKLHVTLYNCSFGRSDCSLCRA-ANP PLXB2_HUMAN PLXB2_HUMAN --------SHDANETLPLHLYVKS----YGKNIDSKLHVTLYNCSFGRSDCSLCRA-ANP Q3LIB1_HUMAN Q3LIB1_HUMAN ------------------------------------------------------------ Q4T033_TETNG Q4T033_TETNG --------------------------------------VGLYNCSVGREDCSLCQH-ADA Q5RH91_DANRE Q5RH91_DANRE ------------------------------------------------------------ A2AFF9_MOUSE A2AFF9_MOUSE QAQQF--YPSMSQWELPVPIYVTR-GEIQRLDNAGDLHVTLYDCAMGHPDCSHCQA-ANG PLXB3_MOUSE PLXB3_MOUSE QAQQF--YPSMSQWELPVPIYVTR-GEIQRLDNAGDLHVTLYDCAMGHPDCSHCQA-ANG B7Z3E6_HUMAN B7Z3E6_HUMAN QAHQF--YPSMSQRELPVPIYVTQ-GEAQRLDNTHALYVILYDCAMGHPDCSHCQA-ANR A8K920_HUMAN A8K920_HUMAN QAHQF--YPSMSQRELPVPIYVTQ-GEAQRLDNTHALYVILYDCAMGHPDCSHCQA-ANR B7Z3H9_HUMAN B7Z3H9_HUMAN QAHQF--YPSMSQRELPVPIYVTQ-GEAQRLDNTHALYVILYDCAMGHPDCSHCQA-ANR PLXB3_HUMAN PLXB3_HUMAN QAHQF--YPSMSQRELPVPIYVTQ-GEAQRLDNTHALYVILYDCAMGHPDCSHCQA-ANR B0V3R5_DANRE B0V3R5_DANRE ---------------------------------------QLYDCSVGQSDCSQCRA-VAA Q4TAV0_TETNG Q4TAV0_TETNG ------------------------------------------------------------ Q4T1S7_TETNG Q4T1S7_TETNG LFREYWTSFSDMD---------RP-PQSPDLNPIENLWDVLERALRSRGKVCHT---AEH A6H8Y2_HUMAN A6H8Y2_HUMAN QQHQL--SYEALQPELRVGLFLRR-AGRLRVDSAEGLHVVLYDCSVGHGDCSRCQT-AMP PLXB1_HUMAN PLXB1_HUMAN QQHQL--SYEALQPELRVGLFLRR-AGRLRVDSAEGLHVVLYDCSVGHGDCSRCQT-AMP B2RWT9_MOUSE B2RWT9_MOUSE QQHQF--SYEALKPELQVGLFLRW-AGGLRVDSADGLHVVLYDCSVGHGDCSRCQT-AMP PLXB1_MOUSE PLXB1_MOUSE QQHQF--SYEALKPELQVGLFLRW-AGGLRVDSADGLHVVLYDCSVGHGDCSRCQT-AMP MATCH CONSENSUS ?????????????????????????????????????????Y?C?????DCS?C??????

Q5RGW1_DANRE Q5RGW1_DANRE SKRCGWTQGREPQLNIQDAC---------------------------------------- Q4RJU9_TETNG Q4RJU9_TETNG GHLCGWCENG---CKPRDDC---QPIMEQCPSPEIHKIFPLRGPVEGGTLLTVQGRNLGR Q6DSU3_DANRE Q6DSU3_DANRE GQECVWCE---HICRQQDQC--PTTSSARCPAPLIHKIEPLSGPLTGGTLLTVTGKNLGH B5DE65_XENTR B5DE65_XENTR GHHCSWSE-SSMSCRLNSEI-LSISYPYTCPAPDIRKIDPASGPLLGGTLVTIQGRNLGS Q0P4P1_XENTR Q0P4P1_XENTR GHHCSWSE-SSMSCRLNSEI-LSISYPYTCPAPDIRKIDPASGPLLGGTLVTIQGRNLGS PLXD1_HUMAN PLXD1_HUMAN GHLCMWSDG----CRLRGPL---QPMAGTCPAPEIRAIEPLSGPLDGGTLLTIRGRNLGR Q3UH93_MOUSE Q3UH93_MOUSE GHLCVWNDG----CRLRGPL---QPLPGTCPAPEIRAIEPLSGPLDGGTLLTIRGRNLGR Q68HV1_MOUSE Q68HV1_MOUSE GHLCVWNDG----CRLRGPL---QPLPGTCPAPEIRAIEPLSGPLDGGTLLTIRGRNLGR Q6ZQ83_MOUSE Q6ZQ83_MOUSE GHLCVWNDG----CRLRGPL---QPLPGTCPAPEIRAIEPLSGPLDGGTLLTIRGRNLGR Q3U3W7_MOUSE Q3U3W7_MOUSE --------------------------------PSID--NPKRSPPE-----------LGE B2RXS4_MOUSE B2RXS4_MOUSE AYRCVWCR-GQNRCVYEALC---SNVTSECPPPVITRIQPETGPLGGGILVTIHGSNLGV Q3UH76_MOUSE Q3UH76_MOUSE AYRCVWCR-GQNRCVYEALC---SNVTSECPPPVITRIQPETGPLGGGILVTIHGSNLGV Q5RAK5_PONAB Q5RAK5_PONAB DYRCAWCG-GQSRCVYEALC----NTTSECPPPVITRIQPETGPLGGGIRITILGSNLGV A6QRH2_HUMAN A6QRH2_HUMAN DYRCAWCG-GQSRCVYEALC----NTTSECPPPVITRIQPETGPLGGGIRITILGSNLGV PLXB2_HUMAN PLXB2_HUMAN DYRCAWCG-GQSRCVYEALC----NTTSECPPPVITRIQPETGPLGGGIRITILGSNLGV Q3LIB1_HUMAN Q3LIB1_HUMAN ------------------------------------------------------------ Q4T033_TETNG Q4T033_TETNG TYQCVWCA-AKRSCVYRELC--GSSAPAQCPEPKITAISPRQGPLNGRILVTIKGSNMGV Q5RH91_DANRE Q5RH91_DANRE ------------------------------------------------------------ A2AFF9_MOUSE A2AFF9_MOUSE SLSCLWCGDGQPACRYGPLC-PPGAVEQLCPIPSIDVIEPLTGPPEGGLAITILGSNLGQ PLXB3_MOUSE PLXB3_MOUSE SLSCLWCGDGQPACRYGPLC-PPGAVEQLCPIPSIDVIEPLTGPPEGGLAITILGSNLGQ B7Z3E6_HUMAN B7Z3E6_HUMAN SLGCLWCADGQPACRYGPLC-PPGAVELLCPAPSIDAVEPLTGPPEGGLALTILGSNLGR A8K920_HUMAN A8K920_HUMAN SLGCLWCADGQPACRYGPLC-PPGAVELLCPAPSIDAVEPLTGPPEGGLALTILGSNLGR B7Z3H9_HUMAN B7Z3H9_HUMAN SLGCLWCADGQPACRYGPLC-PPGAVELLCPAPSIDAVEPLTGPPEGGLALTILGSNLGR PLXB3_HUMAN PLXB3_HUMAN SLGCLWCADGQPACRYGPLC-PPGAVELLCPAPSIDAVEPLTGPPEGGLALTILGSNLGR B0V3R5_DANRE B0V3R5_DANRE SYGCVWCADETPSCVYNQSC--TSGALDTCPPPLITEVEPLTGPLEGGILLTIQGSNLGQ Q4TAV0_TETNG Q4TAV0_TETNG ------------------------------------------------------------ Q4T1S7_TETNG Q4T1S7_TETNG KYGCVWCGSAQASCLYSQSC--SEPVQQTCPEHVIHNIEPLSGLLEGGTMLTISGSNLGQ A6H8Y2_HUMAN A6H8Y2_HUMAN QYGCVWCEGERPRCVTREACGEAEAVATQCPAPLIHSVEPLTGPVDGGTRVTIRGSNLGQ PLXB1_HUMAN PLXB1_HUMAN QYGCVWCEGERPRCVTREACGEAEAVATQCPAPLIHSVEPLTGPVDGGTRVTIRGSNLGQ B2RWT9_MOUSE B2RWT9_MOUSE QYDCVWCEGERPRCVAREACNEAETVATQCPAPLIHSVDPLTGPIDGGTRVTIRGSNLGQ PLXB1_MOUSE PLXB1_MOUSE QYDCVWCEGERPRCVAREACNEAETVATQCPAPLIHSVDPLTGPIDGGTRVTIRGSNLGQ MATCH CONSENSUS ???C?W???????C???????????????CP?P?I????P??GP??GG???T??G?NLG?

Q5RGW1_DANRE Q5RGW1_DANRE ------------------------------------------------------------ Q4RJU9_TETNG Q4RJU9_TETNG RAEAVK--VSIGDVPCSLQPDRYTVSLELVCITGPS----------ADDKTDIVQVDVDQ Q6DSU3_DANRE Q6DSU3_DANRE RADQL--SVSIGGVTCHTLPQQYTVSIRLVCETDAS----------LEQMSGQVTVGVAG B5DE65_XENTR B5DE65_XENTR RFSDINGRVKIGEIECTPIQEKYIVSEEIVCMTGES----------PKLLTDWVSVDVNG Q0P4P1_XENTR Q0P4P1_XENTR RFSDINGRVKIGEIECTPIQEKYIVSEEIVCMTGES----------PKLLTDWVSVDVNG PLXD1_HUMAN PLXD1_HUMAN RLSDVAHGVWIGGVACEPLPDRYTVSEEIVCVTGPA----------PGPLSGVVTVNASK Q3UH93_MOUSE Q3UH93_MOUSE RLSDVAHGVWIGSVACEPLADRYTVSEEIVCATGPA----------AGAFSDVVTVNVSK Q68HV1_MOUSE Q68HV1_MOUSE RLSDVAHGVWIGSVACEPLADRYTVSEEIVCATGPA----------AGAFSDVVTVNVSK Q6ZQ83_MOUSE Q6ZQ83_MOUSE RLSDVAHGVWIGSVACEPLADRYTVSEEIVCATGPA----------AGAFSDVVTVNVSK Q3U3W7_MOUSE Q3U3W7_MOUSE RPDEI------------------------------------------------------- B2RXS4_MOUSE B2RXS4_MOUSE KADDVK-KITVAGQNCAFEPRGYSVSTRIVCAIEAS----------EMPFTGGIEVDVNG Q3UH76_MOUSE Q3UH76_MOUSE KADDVK-KITVAGQNCAFEPRGYSVSTRIVCAIEAS----------EMPFTGGIEVDVNG Q5RAK5_PONAB Q5RAK5_PONAB RAGDIQ-RISVAGRNCSFQPERYSVSTRIVCVIEAA----------EAPFTGGVEVDVFG A6QRH2_HUMAN A6QRH2_HUMAN QAGDIQ-RISVAGRNCSFQPERYSVSTRIVCVIEAA----------ETPFTGGVEVDVFG PLXB2_HUMAN PLXB2_HUMAN QAGDIQ-RISVAGRNCSFQPERYSVSTRIVCVIEAA----------ETPFTGGVEVDVFG Q3LIB1_HUMAN Q3LIB1_HUMAN ------------------------------------------------------------ Q4T033_TETNG Q4T033_TETNG RKEDIK-RITVAGVDCVHQEDRYSVSTSVVCEIGPAKRVPPSDVPFEPTHAGVVEVLVEG Q5RH91_DANRE Q5RH91_DANRE ------------------------------------------------------------ A2AFF9_MOUSE A2AFF9_MOUSE AFNDVRNAVTVAGQPCNPDPSLYRISARIVCVTSPA----------PNGTAGPVQVAIKS PLXB3_MOUSE PLXB3_MOUSE AFNDVRNAVTVAGQPCNPDPSLYRISARIVCVTSPA----------PNGTAGPVQVAIKS B7Z3E6_HUMAN B7Z3E6_HUMAN AFADVQYAVSVASRPCNPEPSLYRTSARIVCVTSPA----------PNGTTGPVRVAIKS A8K920_HUMAN A8K920_HUMAN AFADVQYAVSVASRPCNPEPSLYRTSARIVCVTSPA----------PNGTTGPVRVAIKS B7Z3H9_HUMAN B7Z3H9_HUMAN AFADVQYAVSVASRPCNPEPSLYRTSARIVCVTSPA----------PNGTTGPVRVAIKS PLXB3_HUMAN PLXB3_HUMAN AFADVQYAVSVASRPCNPEPSLYRTSARIVCVTSPA----------PNGTTGPVRVAIKS B0V3R5_DANRE B0V3R5_DANRE SFQDIQAGVTVAGVTCRPLPEAYRISTRIVCELQAS----------VNASAGPVIITVRG Q4TAV0_TETNG Q4TAV0_TETNG ------------------------------------------------------------ Q4T1S7_TETNG Q4T1S7_TETNG KVEDVLYSVSVAGVPCSVIASLYEISSRIVCRTKAS----------GGEKSGQVSVKVSG A6H8Y2_HUMAN A6H8Y2_HUMAN HVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITGAS----------GEEVAGATAVEVPG PLXB1_HUMAN PLXB1_HUMAN HVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITGAS----------GEEVAGATAVEVPG B2RWT9_MOUSE B2RWT9_MOUSE HVQDVLDMVRVAGVPCAVDAGEYDVSSSLVCITGAS----------GEEVTGTVAVEVPG PLXB1_MOUSE PLXB1_MOUSE HVQDVLDMVRVAGVPCAVDAGEYDVSSSLVCITGAS----------GEEVTGTVAVEVPG MATCH CONSENSUS ???????????????C??????Y??S???VC????????????????????????V????

Q5RGW1_DANRE Q5RGW1_DANRE ------KDLLSEYKEPEILSLEPHKVSFNGRNNVLLRGRNLDSV------------TKIR Q4RJU9_TETNG Q4RJU9_TETNG S-GTGTSKESFSYLLPKLLYMEPNKGYRAGGTKVTITGEHLDIG----------SQVRVM Q6DSU3_DANRE Q6DSU3_DANRE D-AVGVSKEQFSFVEPRLLRFSPAQGPLAGGTTLTIQGQFLDAG----------STTDIQ B5DE65_XENTR B5DE65_XENTR G---GRSKEKYSFQVPEVDYLSPDFGPWAGGTRVTISGTNLNIG----------RDVRVL Q0P4P1_XENTR Q0P4P1_XENTR G---GRSKEKYSFQVPEVDYLSPDFGPWAGGTRVTISGTNLNIG----------RDVRVL PLXD1_HUMAN PLXD1_HUMAN E---GKSRDRFSYVLPLVHSLEPTMGPKAGGTRITIHGNDLHVG----------SELQVL Q3UH93_MOUSE Q3UH93_MOUSE E---GRSREQFSYVLPTVHSLEPSMGPKAGGTRITIHGSDLNVG----------SMLQVL Q68HV1_MOUSE Q68HV1_MOUSE E---GRSREQFSYVLPTVHSLEPSMGPKAGGTRITIHGSDLNVG----------SMLQVL Q6ZQ83_MOUSE Q6ZQ83_MOUSE E---GRSREQFSYVLPTVHSLEPSMGPKAGGTRITIHGSDLNVG----------SMLQVL Q3U3W7_MOUSE Q3U3W7_MOUSE -------------------------------------------G---------------- B2RXS4_MOUSE B2RXS4_MOUSE KLGHSPPHVQFTYQQPQPLSVEPRQGPQAGGTTLTINGTHLDTG--------SKEDVRVT Q3UH76_MOUSE Q3UH76_MOUSE KLGHSPPHVQFTYQQPQPLSVEPRQGPQAGGTTLTINGTHLDTG--------SKEDVRVT Q5RAK5_PONAB Q5RAK5_PONAB KLGRSPPNVQFTFQQPQPLSVEPQQGPQAGGTTLTIHGTHLDTG--------SQEDARVT A6QRH2_HUMAN A6QRH2_HUMAN KLGRSPPNVQFTFQQPKPLSVEPQQGPQAGGTTLTIHGTHLDTG--------SQEDVRVT PLXB2_HUMAN PLXB2_HUMAN KLGRSPPNVQFTFQQPKPLSVEPQQGPQAGGTTLTIHGTHLDTG--------SQEDVRVT Q3LIB1_HUMAN Q3LIB1_HUMAN -------------------------------------------G---------------- Q4T033_TETNG Q4T033_TETNG G-RSGMSEFNFTYRDPEPTAVEPARGPAAGGTVITIKGKYLNTA--------SKEDISIT Q5RH91_DANRE Q5RH91_DANRE --------------------------------VITITGQDLDSA--------SKDDITIT A2AFF9_MOUSE A2AFF9_MOUSE R-PPGISTQNFTYQDPVLLSLNPQWGPQAGGTQLTIHGQYLQTG----------GNISVF PLXB3_MOUSE PLXB3_MOUSE R-PPGISTQNFTYQDPVLLSLNPQWGPQAGGTQLTIHGQYLQTG----------GNISVF B7Z3E6_HUMAN B7Z3E6_HUMAN Q-PPGISSQHFTYQDPVLLSLSPRWGPQAGGTQLTIRGQHLQTG----------GNTSAF A8K920_HUMAN A8K920_HUMAN Q-PPGISSQHFTYQDPVLLSLSPRWGPQAGGTQLTIRGQHLQTG----------GNTSAF B7Z3H9_HUMAN B7Z3H9_HUMAN Q-PPGISSQHFTYQDPVLLSLSPRWGPQAGGTQLTIRGQHLQTG----------GNTSAF PLXB3_HUMAN PLXB3_HUMAN Q-PPGISSQHFTYQDPVLLSLSPRWGPQAGGTQLTIRGQHLQTG----------GNTSAF B0V3R5_DANRE B0V3R5_DANRE S-ERGESQQTFSYQNPQLSRIVPEKGPLAGGTLLMVYGSQLLTGQNLQQRSDQITGLQAF Q4TAV0_TETNG Q4TAV0_TETNG ------------------------------------------------------------ Q4T1S7_TETNG Q4T1S7_TETNG G-DLGLSTDLFTYQDPFVMSVSPNRGPKAGGTVLTISGRNLLTG--------RLSDIRIT A6H8Y2_HUMAN A6H8Y2_HUMAN R-GRGVSEHDFAYQDPKVHSIFPARGPRAGGTRLTLNGSKLLTG--------RLEDIRVV PLXB1_HUMAN PLXB1_HUMAN R-GRGVSEHDFAYQDPKVHSIFPARGPRAGGTRLTLNGSKLLTG--------RLEDIRVV B2RWT9_MOUSE B2RWT9_MOUSE R-GHGVSEFSFAYQDPKVHSIFPARGPRAGGTRLTLHGSKLLTG--------RLEDIRVV PLXB1_MOUSE PLXB1_MOUSE R-GHGVSEFSFAYQDPKVHSIFPARGPRAGGTRLTLHGSKLLTG--------RLEDIRVV MATCH CONSENSUS ???????????????P??????P??GP?AGGT??T??G??L??G????????????????

Q5RGW1_DANRE Q5RGW1_DANRE IQGDLGCIAKESPVFDPSSDTLVFNIPP----SESKGTVKMCVVTPDNRC---HGNSIIT Q4RJU9_TETNG Q4RJU9_TETNG VNNTHKCV-----ITEKTDNVIECTMPA--ITQAHADSVSVCVEFENLTCQGPDLATTYT Q6DSU3_DANRE Q6DSU3_DANRE INNTHTCS-----IRTRSSEIIRCVMPA----AASAENVSVCVVFDGRPCVSASPNFTFS B5DE65_XENTR B5DE65_XENTR FNKTQECR-----DLVRTQSTIQCTVPP--MKFLPETKVHICVQFEKKSC--VKEELFFK Q0P4P1_XENTR Q0P4P1_XENTR FNKTQECR-----DLVRTQSTIQCTVPP--MKFLPETKVHICVQFEKKSC--VKEELFFK PLXD1_HUMAN PLXD1_HUMAN VNDTDPCT-----ELMRTDTSIACTMPE----GALPAPVPVCVRFERRGC--VHGNLTFW Q3UH93_MOUSE Q3UH93_MOUSE VNDTDPCT-----DLTRTATSITCTVPG----GTLPSPVPVCVRFESRGC--VHGNLTFW Q68HV1_MOUSE Q68HV1_MOUSE VNDTDPCT-----DLTRTATSITCTVPG----GTLPSPVPVCVRFESRGC--VHGNLTFW Q6ZQ83_MOUSE Q6ZQ83_MOUSE VNDTDPCT-----DLTRTATSITCTVPG----GTLPSPVPVCVRFESRGC--VHGNLTFW Q3U3W7_MOUSE Q3U3W7_MOUSE ------------------------------------------------------------ B2RXS4_MOUSE B2RXS4_MOUSE LND-VPCE------VTKFGAQLQCVTGQ----QLAPGQVTLEIYYGGSRV--PSPGISFT Q3UH76_MOUSE Q3UH76_MOUSE LND-VPCE------VTKFGAQLQCVTGQ----QLAPGQVTLEIYYGGSRV--PSPGISFT Q5RAK5_PONAB Q5RAK5_PONAB LNG-VPCK------VTKFGAQLQCVTGP----QATRGQMLLEVSYGGSPV--PSPGIFFT A6QRH2_HUMAN A6QRH2_HUMAN LNG-VPCK------VTKFGAQLQCVTGP----QATRGQMLLEVSYGGSPV--PNPGIFFT PLXB2_HUMAN PLXB2_HUMAN LNG-VPCK------VTKFGAQLQCVTGP----QATRGQMLLEVSYGGSPV--PNPGIFFT Q3LIB1_HUMAN Q3LIB1_HUMAN ----IPCK------VTKFGAQLQCVTGP----QATRGQMLLEVSYGGSPV--PNPGIFFT Q4T033_TETNG Q4T033_TETNG VAALRPGDEGSLRFSLSFGDVITCTTGRYSEQKLPSDPMAVRVNYGRDTT--KEVASAFQ Q5RH91_DANRE Q5RH91_DANRE VDK-EPCE------VLTFGHEITCKTGPYKGQKIPSDKLPVIVKYGKDTV--KTVDA-FE A2AFF9_MOUSE A2AFF9_MOUSE VGD-QPCP----IQEPVCPEAIICHTMP----QTEPGEAVVLIVFGHVER--KLLTTPFR PLXB3_MOUSE PLXB3_MOUSE VGD-QPCP----IQEPVCPEAIICHTMP----QTEPGEAVVLIVFGHVER--KLLTTPFR B7Z3E6_HUMAN B7Z3E6_HUMAN VGG-QPCP----ILEPVCPEAIVCRTRP----QAAPGEAAVLVVFGHAQR--TLLASPFR A8K920_HUMAN A8K920_HUMAN VGG-QPCP----ILEPVCPEAIVCRTRP----QAAPGEAAVLVVFGHAQR--TLLASPFR B7Z3H9_HUMAN B7Z3H9_HUMAN VGG-QPCP----ILEPVCPEAIVCRTRP----QAAPGEAAVLVVFGHAQR--TLLASPFR PLXB3_HUMAN PLXB3_HUMAN VGG-QPCP----ILEPVCPEAIVCRTRP----QAAPGEAAVLVVFGHAQR--TLLASPFR B0V3R5_DANRE B0V3R5_DANRE LGS-QPCR-----IKEVSDTRMICHTSH----ANQTGKVLLRVVFGKAER--ILSNVLFS Q4TAV0_TETNG Q4TAV0_TETNG ----------------------------------------VRVLFGKAER--AIGSVRFR Q4T1S7_TETNG Q4T1S7_TETNG VGG-VSCH---------------------------------------------------- A6H8Y2_HUMAN A6H8Y2_HUMAN VGD-QPCH----LLPEQQSEQLRCETSP----RPTPATLPVAVWFGATER--RLQRGQFK PLXB1_HUMAN PLXB1_HUMAN VGD-QPCH----LLPEQQSEQLRCETSP----RPTPATLPVAVWFGATER--RLQRGQFK B2RWT9_MOUSE B2RWT9_MOUSE VGD-QPCH----LLLEQQSEQLHCETGP----YPVPAELPVTVLFGATER--RLQHGQFK PLXB1_MOUSE PLXB1_MOUSE VGD-QPCH----LLLEQQSEQLHCETGP----YPVPAELPVTVLFGATER--RLQHGQFK MATCH CONSENSUS ??????C????????????????C??????????????????V???????????????F?

Q5RGW1_DANRE Q5RGW1_DANRE YSSQPRCTGVQPRNSWRSGGRKIHVQGTNMEYVESVIVQP-------------------- Q4RJU9_TETNG Q4RJU9_TETNG YKKNPTIFFIKPTKSYLSGGRTITVTGQGFDLVQSATMQV----------------EGIG Q6DSU3_DANRE Q6DSU3_DANRE YQKNPTISHIWPSRSYISGGRSISVSGVGFDLVQSVVMEV-------------------- B5DE65_XENTR B5DE65_XENTR YQENPVIKSMDPRSSPLSGGRIITVTGERFDMVQSIMMGI---------------QHEKG Q0P4P1_XENTR Q0P4P1_XENTR YQENPVIKSMDPRSSPLSGGRIITVTGERFDMVQSIMMGI-------------------- PLXD1_HUMAN PLXD1_HUMAN YMQNPVITAISPRRSPVSGGRTITVAGERFHMVQNVSMAV-------HHIGRE------- Q3UH93_MOUSE Q3UH93_MOUSE YMQNPVITAISPGRSPVSGGRTITVAGERFHMVQNVSMAV-------HHIGRE------- Q68HV1_MOUSE Q68HV1_MOUSE YMQNPVITAISPGRSPVSGGRTITVAGERFHMVQNVSMAV-------HHIGRE------- Q6ZQ83_MOUSE Q6ZQ83_MOUSE YMQNPVITAISPGRSPVSGGRTITVAGERFHMVQNVSMAV-------HHIGRE------- Q3U3W7_MOUSE Q3U3W7_MOUSE ------------------------------------------------------------ B2RXS4_MOUSE B2RXS4_MOUSE YCENPMIRAFEPLRSFVSGGRSINVTGQGFSLIQKFAMVV-------IAEPLRSWRRRRR Q3UH76_MOUSE Q3UH76_MOUSE YCENPMIRAFEPLRSFVSGGRSINVTGQGFSLIQKFAMVV-------IAEPLRSWRRRRR Q5RAK5_PONAB Q5RAK5_PONAB YRENPVLRAFEPLRSFAGGGRSINVTGQGFSLIQRFAMVV-------IAEPLQSWQPPR- A6QRH2_HUMAN A6QRH2_HUMAN YRENPVLRAFEPLRSFASGGRSINVTGQGFSLIQRFAMVV-------IAEPLQSWQPPR- PLXB2_HUMAN PLXB2_HUMAN YRENPVLRAFEPLRSFASGGRSINVTGQGFSLIQRFAMVV-------IAEPLQSWQPPR- Q3LIB1_HUMAN Q3LIB1_HUMAN YRENPVLRAFEPLRSFASGGRSINVTGQGFSLIQRFAMVV-------IAEPLQSWQPPR- Q4T033_TETNG Q4T033_TETNG YCENPKVSEYSPKASFVCGGRKIKVVGNGFDLIQRATMRV-------LPSTD-EFSENTA Q5RH91_DANRE Q5RH91_DANRE YSPDPKISEYFPQTSFVCGGRRILVIGSGFDQVQRATMRV-------LPSSDE------- A2AFF9_MOUSE A2AFF9_MOUSE YTANPQLVEAEPSVSFRGGGRVIRVRGTGLDVVWQPLLSVWLEDEPKVKALGVQAQDANP PLXB3_MOUSE PLXB3_MOUSE YTANPQLVEAEPSVSFRGGGRVIRVRGTGLDVVWQPLLSVWLEDEPKVKALGVQAQDANP B7Z3E6_HUMAN B7Z3E6_HUMAN YTANPQLVAAEPSASFRGGGRLIRVRGTGLDVVQRPLLSVWLEADAEVQASRAQPQDPQP A8K920_HUMAN A8K920_HUMAN YTANPQLVAAEPSASFRGGGRLIRVRGTGLDVVQRPLLSVWLEADAEVQASRAQPQDPQP B7Z3H9_HUMAN B7Z3H9_HUMAN YTANPQLVAAEPSASFRGGGRLIRVRGTGLDVVQRPLLSVWLEADAEVQASRAQPQDPQP PLXB3_HUMAN PLXB3_HUMAN YTANPQLVAAEPSASFRGGGRLIRVRGTGLDVVQRPLLSVWLEADAEVQASRAQPQDPQP B0V3R5_DANRE B0V3R5_DANRE YMEDPLITDADPTESFYGGGRFIFVTGQNLNVVQQPKMWVSFEPRDRFEARRRRYTHVSV Q4TAV0_TETNG Q4TAV0_TETNG YLDDPVITEASPAESFYAGGRVVMVTGRNLDVVQRPVLAVWVEP---VEVQRV------- Q4T1S7_TETNG Q4T1S7_TETNG -----------------IGGRFIYVSGHNLDVVQEPRMVV------TVSSQ-LVNQRGGR A6H8Y2_HUMAN A6H8Y2_HUMAN YTLDPNITSAGPTKSFLSGGREICVRGQNLDVVQTPRIRV------TVVSRMLQPSQGLG PLXB1_HUMAN PLXB1_HUMAN YTLDPNITSAGPTKSFLSGGREICVRGQNLDVVQTPRIRV------TVVSRMLQPSQGLG B2RWT9_MOUSE B2RWT9_MOUSE YTSDPNVTSVGPSKSFFSGGREIWVRGQDLDVVQRPRIRV-------TVVPRQHGQ-GLA PLXB1_MOUSE PLXB1_MOUSE YTSDPNVTSVGPSKSFFSGGREIWVRGQDLDVVQRPRIRV-------TVVPRQHGQ-GLA MATCH CONSENSUS Y???P??????P??S???GGR?I?V?G??????Q?????V????????????????????

Q5RGW1_DANRE Q5RGW1_DANRE -------------------------------SNIFLKSQYDASSRDMWFYSHRIEGSDHF Q4RJU9_TETNG Q4RJU9_TETNG RTT------------------------CGVISNNTIHCPSHPSSE---SQQTAVQ----F Q6DSU3_DANRE Q6DSU3_DANRE ----------PGVG----------QTNCSCVSSTLILCQSPAADQ---AQQTAVL----F B5DE65_XENTR B5DE65_XENTR RRMN-----------------------CTVLSPTIITCPSPTAPN---STMENMD----F Q0P4P1_XENTR Q0P4P1_XENTR ------------------------------------------------------------ PLXD1_HUMAN PLXD1_HUMAN ------------------------PTLCKVLNSTLITCPSPGALS---NASAPVD----F Q3UH93_MOUSE Q3UH93_MOUSE ------------------------PTFCKVLNSTLITCPSPGALS---NASAPVD----F Q68HV1_MOUSE Q68HV1_MOUSE ------------------------PTFCKVLNSTLITCPSPGALS---NASAPVD----F Q6ZQ83_MOUSE Q6ZQ83_MOUSE ------------------------PTFCKVLNSTLITCPSPGALS---NASAPVD----F Q3U3W7_MOUSE Q3U3W7_MOUSE -----------------------------------------------------------F B2RXS4_MOUSE B2RXS4_MOUSE EAGALERVTVEGME-------------YVFYNDTKVVFLSPAVPEEPEAYNLTVL----I Q3UH76_MOUSE Q3UH76_MOUSE EAGALERVTVEGME-------------YVFYNDTKVVFLSPAVPEEPEAYNLTVL----I Q5RAK5_PONAB Q5RAK5_PONAB EAESPQPMTVVGTD-------------YVFHNDTKVVFLSPAVPEEPEAYNLTVL----I A6QRH2_HUMAN A6QRH2_HUMAN EAESLQPMTVVGTD-------------YVFHNDTKVVFLSPAVPEEPEAYNLTVL----I PLXB2_HUMAN PLXB2_HUMAN EAESLQPMTVVGTD-------------YVFHNDTKVVFLSPAVPEEPEAYNLTVL----I Q3LIB1_HUMAN Q3LIB1_HUMAN EAESLQPMTVVGTD-------------YVFHNDTKVVFLSPAVPEEPEAYNLTVL----I Q4T033_TETNG Q4T033_TETNG PAEFVQEGKK--------------------ENDTVLHFDSPVVNGSCDVRSLRTF----L Q5RH91_DANRE Q5RH91_DANRE --------------FDVKASNVEFFQEVEKKNETTLEFLSPVVNKTYINLSLRTV----I A2AFF9_MOUSE A2AFF9_MOUSE RRSCGAPAADPQACIHLESGLLQCSTLCSVNSSSLLLCHSPAVPDG--ALPKRVF----F PLXB3_MOUSE PLXB3_MOUSE RRSCGAPAADPQACIHLESGLLQCSTLCSVNSSSLLLCHSPAVPDG--ALPKRVF----F B7Z3E6_HUMAN B7Z3E6_HUMAN RRSCGAPAADPQACIQLGGGLLQCSTVCSVNSSSLLLCRSPAVPDR--AHPQRVF----F A8K920_HUMAN A8K920_HUMAN RRSCGAPAADPQACIQLGGGLLQCSTVCSVNSSSLLLCRSPAVPDR--AHPQRVF----F B7Z3H9_HUMAN B7Z3H9_HUMAN RRSCGAPAADPQACIQLGGGLLQCSTVCSVNSSSLLLCRSPAVPDR--AHPQRVF----F PLXB3_HUMAN PLXB3_HUMAN RRSCGAPAADPQACIQLGGGLLQCSTVCSVNSSSLLLCRSPAVPDR--AHPQRVF----F B0V3R5_DANRE B0V3R5_DANRE RNPLVTSQS------------------CTNVTSEQMICKSPEVTPN--SRVIRVW----F Q4TAV0_TETNG Q4TAV0_TETNG RRRRRLALLTSRQQLVFNGTMTTVTEPCSVLSSSQMTCRTPRVTPD--LKIKGVW----F Q4T1S7_TETNG Q4T1S7_TETNG RGRSMVPKNSGCPE-NRHCSVREFSERCDVNSSSLMLCRSPSVDSSAMGSKVTVE----S A6H8Y2_HUMAN A6H8Y2_HUMAN RRRRVVPETACSLG--PSCSSQQFEEPCHVNSSQLITCRTPALPGLPEDPWVRVE----F PLXB1_HUMAN PLXB1_HUMAN RRRRVVPETACSLG--PSCSSQQFEEPCHVNSSQLITCRTPALPGLPEDPWVRVE----F B2RWT9_MOUSE B2RWT9_MOUSE QKQHVVPE--------------KFEEPCLVNSSHLLMCRTPALPGPPWDSGVQVE----F PLXB1_MOUSE PLXB1_MOUSE QKQHVVPE--------------KFEEPCLVNSSHLLMCRTPALPGPPWDSGVQVE----F MATCH CONSENSUS ????????????????????????????????????????P????????????V??????

Q5RGW1_DANRE Q5RGW1_DANRE TLSLMVG----NSTEACD--------------HDFSYEPDPVFTGFTTLQVANDLQVN-- Q4RJU9_TETNG Q4RJU9_TETNG FLNGVLYTDEGPLSPDSGEEEEEEEEDSNKGHFTLEYVEDPQFFTANKEKLIKHHPGEPL Q6DSU3_DANRE Q6DSU3_DANRE SLNGVQY----RDAASAG---LEEGEQPHTQRYSFQYVEDPQFYTANKEKLIKHHPGEPL B5DE65_XENTR B5DE65_XENTR FINGVQV----DLGKAIV-----------EAHFSLEYQPDPMFYTAKKEKLIKHHVGEPL Q0P4P1_XENTR Q0P4P1_XENTR ------------------------------------------------------------ PLXD1_HUMAN PLXD1_HUMAN FINGRAY----ADEVAVAEELLDPEEAQRGSRFRLDYLPNPQFSTAKREKWIKHHPGEPL Q3UH93_MOUSE Q3UH93_MOUSE FINGRAY----ADEAAEE--LLDPAEAQRGSRFRLDYLPNPQFSTAKREKWIKHHPGEPL Q68HV1_MOUSE Q68HV1_MOUSE FINGRAY----ADEAAEE--LLDPAEAQRGSRFRLDYLPNPQFSTAKREKWIKHHPGEPL Q6ZQ83_MOUSE Q6ZQ83_MOUSE FINGRAY----ADEAAEE--LLDPAEAQRGSRFRLDYLPNPQFSTAKREKWIKHHPGEPL Q3U3W7_MOUSE Q3U3W7_MOUSE IMDNVRT----LLVLNSS---------------SFLYYPDPVLEPLSPTGL---LELKPS B2RXS4_MOUSE B2RXS4_MOUSE RMDGHCA----PLRTEAG---------------VFEYVADPTFENFTGG-----VKKQVN Q3UH76_MOUSE Q3UH76_MOUSE RMDGHCA----PLRTEAG---------------VFEYVADPTFENFTGG-----VKKQVN Q5RAK5_PONAB Q5RAK5_PONAB EMDGHRA----LLRTEAG---------------AFEYVPDPTFENFTGG-----VKKQVN A6QRH2_HUMAN A6QRH2_HUMAN EMDGHRA----LLRTEAG---------------AFEYVPDPTFENFTGG-----VKKQVN PLXB2_HUMAN PLXB2_HUMAN EMDGHRA----LLRTEAG---------------AFEYVPDPTFENFTGG-----VKKQVN Q3LIB1_HUMAN Q3LIB1_HUMAN EMDGHRA----LLRTEAG---------------AFEYVPDPTFENFTGG-----VKKQVN Q4T033_TETNG Q4T033_TETNG HLDNVVE----EL-------------------KSFVYHPEPTFDKLQKNVITET------ Q5RH91_DANRE Q5RH91_DANRE QLDNLVL----NLT-------------------DFAYHPDPHFDKLKDKAITE------G A2AFF9_MOUSE A2AFF9_MOUSE ALDNMQV----DFASASG-------------GQGFLYQPNPRLAPLSHEGITHPYHLKPG PLXB3_MOUSE PLXB3_MOUSE ALDNMQV----DFASASG-------------GQGFLYQPNPRLAPLSHEGITHPYHLKPG B7Z3E6_HUMAN B7Z3E6_HUMAN TLDNVQV----DFASASG-------------GQGFLYQPNPRLAPLSRDGPARPYRLKPG A8K920_HUMAN A8K920_HUMAN TLDNVQV----DFASASG-------------GQGFLYQPNPRLAPLSRDGPARPYRLKPG B7Z3H9_HUMAN B7Z3H9_HUMAN TLDNVQV----DFASASG-------------GQGFLYQPNPRLAPLSREGPARPYRLKPG PLXB3_HUMAN PLXB3_HUMAN TLDNVQV----DFASASG-------------GQGFLYQPNPRLAPLSREGPARPYRLKPG B0V3R5_DANRE B0V3R5_DANRE EMDNVHI----DFSSIKN--------------KPFTYHPNPDLFPLNSESRGTAIRFKPG Q4TAV0_TETNG Q4TAV0_TETNG QMDNVRI----HFKSIRG--------------QSFSYFPNPEFFPLNREAPNAPYRFKPG Q4T1S7_TETNG Q4T1S7_TETNG LLDNLRF----DFSSLSP--------------QPFTYEPNPNLRPLNQQDPLKAYRYNPG A6H8Y2_HUMAN A6H8Y2_HUMAN ILDNLVF----DFATLNP--------------TPFSYEADPTLQPLNPEDPTMPFRHKPG PLXB1_HUMAN PLXB1_HUMAN ILDNLVF----DFATLNP--------------TPFSYEADPTLQPLNPEDPTMPFRHKPG B2RWT9_MOUSE B2RWT9_MOUSE ILDNMVF----DFAALSP--------------TPFSYEADPTLRSLNPEDPSTPFRHKPG PLXB1_MOUSE PLXB1_MOUSE ILDNMVF----DFAALSP--------------TPFSYEADPTLRSLNPEDPSTPFRHKPG MATCH CONSENSUS ????????????????????????????????????Y???P???????????????????

Q5RGW1_DANRE Q5RGW1_DANRE --IQKK-----------ADKL---NLNISEVKVAGLHGDKGYQCV-VERIESNAVICK-- Q4RJU9_TETNG Q4RJU9_TETNG TLIINK-----------GPS----DLDLVPEEYSVMIGSY--PCN-ISFHNDQLFHCT-- Q6DSU3_DANRE Q6DSU3_DANRE ILIINK-----------GPS----DLDLTLDEYSVTIGSD--LCD-ITFHNQQLFHCS-- B5DE65_XENTR B5DE65_XENTR TLVIHK-----------EPD----NLGLRVDEYRVKVGQI--PCESIFIFNDKVIHCS-- Q0P4P1_XENTR Q0P4P1_XENTR ------------------------------------------------------------ PLXD1_HUMAN PLXD1_HUMAN TLVIHK-----------EQD----SLGLQSHEYRVKIGQV--SCD-IQIVSDRIIHCS-- Q3UH93_MOUSE Q3UH93_MOUSE TLVIHK-----------EQD----SLGLESHEYHIKIGQV--SCD-IQIISDRVIHCS-- Q68HV1_MOUSE Q68HV1_MOUSE TLVIHK-----------EQD----SLGLESHEYHIKIGQV--SCD-IQIISDRVIHCS-- Q6ZQ83_MOUSE Q6ZQ83_MOUSE TLVIHK-----------EQD----SLGLESHEYHIKIGQV--SCD-IQIISDRVIHCS-- Q3U3W7_MOUSE Q3U3W7_MOUSE SPLILK-----------GRNLLPPAPGNSRLNYTVLIGST--PC--ILTVSETQLLCEAP B2RXS4_MOUSE B2RXS4_MOUSE KLIHAR-----------GTNL---NKAMTLEEAEAFVGAE--RCI-MKTLTETDLYCEPP Q3UH76_MOUSE Q3UH76_MOUSE KLIHAR-----------GTNL---NKAMTLEEAEAFVGAE--RCI-MKTLTETDLYCEPP Q5RAK5_PONAB Q5RAK5_PONAB KLIHAR-----------GTNL---NKAMTLQEAEAFVGAE--RCT-MKTLTETDLYCEPP A6QRH2_HUMAN A6QRH2_HUMAN KLIHAR-----------GTNL---NKAMTLQEAEAFVGAE--RCT-MKTLTETDLYCEPP PLXB2_HUMAN PLXB2_HUMAN KLIHAR-----------GTNL---NKAMTLQEAEAFVGAE--RCT-MKTLTETDLYCEPP Q3LIB1_HUMAN Q3LIB1_HUMAN KLIHAR-----------GTNL---NKAMTLQEAEAFVGAE--RCT-MKTLTETDLYCEPP Q4T033_TETNG Q4T033_TETNG SIIIVT-----------GRGF---DKAMTVPEAKAFVGDA--PCH-VNILQGDKLILEAP Q5RH91_DANRE Q5RH91_DANRE SIINVN-----------GRGF---AKAMTAKEAQAFVGDE--SCL-VTILEDDKLFLVAP A2AFF9_MOUSE A2AFF9_MOUSE HVLDVE-----------GEGL---NLGISKEEVQVHIGDG--ECL-VKTLTLTHLYCEPP PLXB3_MOUSE PLXB3_MOUSE HVLDVE-----------GEGL---NLGISKEEVQVHIGDG--ECL-VKTLTLTHLYCEPP B7Z3E6_HUMAN B7Z3E6_HUMAN HVLDVE-----------GEGL---NLGISKEEVRVHIGRG--ECL-VKTLTRTHLYCEPP A8K920_HUMAN A8K920_HUMAN HVLDVE-----------GEGL---NLGISKEEVRVHIGRG--ECL-VKTLTRTHLYCEPP B7Z3H9_HUMAN B7Z3H9_HUMAN HVLDVE-----------GEGL---NLGISKEEVRVHIGRG--ECL-VKTLTRTHLYCEPP PLXB3_HUMAN PLXB3_HUMAN HVLDVE-----------GEGL---NLGISKEEVRVHIGRG--ECL-VKTLTRTHLYCEPP B0V3R5_DANRE B0V3R5_DANRE G----------------GKGL---MLAMSKEEVQAWLGNQ--ECD-VKTLDNTHLYCEPP Q4TAV0_TETNG Q4TAV0_TETNG GVIAVEFTPPCLHGNPQGQHL---TRAISRHEVTARLGDE--ECE-VKTLDHTHLYCEPP Q4T1S7_TETNG Q4T1S7_TETNG SFIQLE-----------GENL---DLAITKDEVVVLIGEG--VCA-VKTLTRNHLYCEPP A6H8Y2_HUMAN A6H8Y2_HUMAN SVFSVE-----------GENL---DLAMSKEEVVAMIGDG--PCV-VKTLTRHHLYCEPP PLXB1_HUMAN PLXB1_HUMAN SVFSVE-----------GENL---DLAMSKEEVVAMIGDG--PCV-VKTLTRHHLYCEPP B2RWT9_MOUSE B2RWT9_MOUSE SVFSVE-----------GENL---DLAMSKEEVVAMIGDG--PCV-VKTLTRNHLYCEPP PLXB1_MOUSE PLXB1_MOUSE SVFSVE-----------GENL---DLAMSKEEVVAMIGDG--PCV-VKTLTRNHLYCEPP MATCH CONSENSUS ???????????????????????????????E?????G?????C????????????C???

Q5RGW1_DANRE Q5RGW1_DANRE -----IKAGPG------ALDSLNISIGHFYV---KQTFESPSGMKYFSI-----LVVLIV Q4RJU9_TETNG Q4RJU9_TETNG -INGLLGSSER-------ELPVIVQVGNFRHTIAKVQLGGS------ELAIVVSIVVCCV Q6DSU3_DANRE Q6DSU3_DANRE -INRSLSASTG-------ELPVTVRVGHFQKVIAMVQMGGGS-----ELAIVVSIVVCCV B5DE65_XENTR B5DE65_XENTR -INESLSSSQR-------YLPVTIQVGKFNQTITTLHLAG------IDTSIIISIVICSI Q0P4P1_XENTR Q0P4P1_XENTR ------------------------------------------------------------ PLXD1_HUMAN PLXD1_HUMAN -VNESLGAAVG-------QLPITIQVGNFNQTIATLQLGGS------ETAIIVSIVICSV Q3UH93_MOUSE Q3UH93_MOUSE -VNESLGTAEG-------QLPITIQVGNFNQTIATLQLGGS------ETAIVVSIVICSV Q68HV1_MOUSE Q68HV1_MOUSE -VNESLGTAEG-------QLPITIQVGNFNQTIATLQLGGS------ETAIVVSIVICSV Q6ZQ83_MOUSE Q6ZQ83_MOUSE -VNESLGTAEG-------QLPITIQVGNFNQTIATLQLGGS------ETAIVVSIVICSV Q3U3W7_MOUSE Q3U3W7_MOUSE -------NLTG-------QHKVTVRAGGFEFSPGMLQVYSD---SLLTLPAIVGIGGGGG B2RXS4_MOUSE B2RXS4_MOUSE EVQPPPKRRQK-RDTAHNLPEFIVKFGSREWVLGRVEYDTR--ASDVPLSLILPLVMVPM Q3UH76_MOUSE Q3UH76_MOUSE EVQPPPKRRQK-RDTAHNLPEFIVKFGSREWVLGRVEYDTR--ASDVPLSLILPLVMVPM Q5RAK5_PONAB Q5RAK5_PONAB EVQPPPKRRQK-RDTTHNLPEFIVKFGSREWVLGRVEYDTR--VSDVPLSLILPLVIVPM A6QRH2_HUMAN A6QRH2_HUMAN EVQPPPKRRQK-RDTTHNLPEFIVKFGSREWVLGRVEYDTR--VSDVPLSLILPLVIVPM PLXB2_HUMAN PLXB2_HUMAN EVQPPPKRRQK-RDTTHNLPEFIVKFGSREWVLGRVEYDTR--VSDVPLSLILPLVIVPM Q3LIB1_HUMAN Q3LIB1_HUMAN EVQPPPKRRQK-RDTTHNLPEFIVKFGSREWVLGRVEYDTR--VSDVPLSLILPLVIVPM Q4T033_TETNG Q4T033_TETNG AQQRRDTANE--------MLELVVKFGQCERLVDSVYYARK---EGIPLAIIIPVVILPM Q5RH91_DANRE Q5RH91_DANRE SSPPKSTSRRHRRDTSSDALELLIKFGNGEWNVGSVRFERK---YEVPLYIIIPAVLIPM A2AFF9_MOUSE A2AFF9_MOUSE PQAPQPTNGSG------TLPQFVVQMGNLRLALGPVQYEAESMMSTFPVEAQLGLGMGAA PLXB3_MOUSE PLXB3_MOUSE PQAPQPTNGSG------TLPQFVVQMGNLRLALGPVQYEAESMMSTFPVEAQLGLGMGAA B7Z3E6_HUMAN B7Z3E6_HUMAN AHAPQPANGSG-------LPQFVVQMGNVQLALGPVQYEAEPPLSAFPVEAQAGVGMGAA A8K920_HUMAN A8K920_HUMAN AHAPQPANGSG-------LPQFVVQMGNVQLALGPVQYEAEPPLSAFPVEAQAGVGMGAA B7Z3H9_HUMAN B7Z3H9_HUMAN AHAPQPANGSG-------LPQFVVQMGNVQLALGPVQYEAEPPLSAFPVEAQAGVGMGAA PLXB3_HUMAN PLXB3_HUMAN AHAPQPANGSG-------LPQFVVQMGNVQLALGPVQYEAEPPLSAFPVEAQAGVGMGAA B0V3R5_DANRE B0V3R5_DANRE DVQPLALDDSN-------LPTLKVLMGGLAFDLGPVQYDSD-LHSPVPLAAQIGLAAGAA Q4TAV0_TETNG Q4TAV0_TETNG EIQPASADGGE-------LPSLKVFMGSLQVDLGPVQYDSDSLLSPVPLAAQISLAAVAA Q4T1S7_TETNG Q4T1S7_TETNG PQQPSPVLNGRNREGSDSLPEFTVQMGNLNFSLGKVQYDNLS-LSTFPLEAQIGVGVGAS A6H8Y2_HUMAN A6H8Y2_HUMAN VEQPLPRHHAL-REAPDSLPEFTVQMGNLRFSLGHVQYDGESP-GAFPVAAQVGLGVGTS PLXB1_HUMAN PLXB1_HUMAN VEQPLPRHHAL-REAPDSLPEFTVQMGNLRFSLGHVQYDGESP-GAFPVAAQVGLGVGTS B2RWT9_MOUSE B2RWT9_MOUSE VEQPLPHPHAL-REAPDALPEFTVQMGNLRFSLGHVQYDGESPV-AFPVAAQVGLGVGTS PLXB1_MOUSE PLXB1_MOUSE VEQPLPHPHAL-REAPDALPEFTVQMGNLRFSLGHVQYDGESPV-AFPVAAQVGLGVGTS MATCH CONSENSUS ??????????????????????????G?????????????????????????????????

Q5RGW1_DANRE Q5RGW1_DANRE IIILGAVVGVIVH------------------------RKSQKQMSK---KMNDQLELMES Q4RJU9_TETNG Q4RJU9_TETNG LLLLCTVAL-VVY------------------------CTKSRRAERYWQKTLLQMEEMES Q6DSU3_DANRE Q6DSU3_DANRE LLLLCTVAL-VVY------------------------CTKSRRAERYWQKTLVQMEEMES B5DE65_XENTR B5DE65_XENTR LLLLSVVAL-FVF------------------------CTKSRRAERYWQKTLVQMEEMES Q0P4P1_XENTR Q0P4P1_XENTR ------------------------------------------------------------ PLXD1_HUMAN PLXD1_HUMAN LLLLSVVAL-FVF------------------------CTKSRRAERYWQKTLLQMEEMES Q3UH93_MOUSE Q3UH93_MOUSE LLLLSVVAL-FVF------------------------CTKSRRAERYWQKTLLQMEEMES Q68HV1_MOUSE Q68HV1_MOUSE LLLLSVVAL-FVF------------------------CTKSRRAERYWQKTLLQMEEMES Q6ZQ83_MOUSE Q6ZQ83_MOUSE LLLLSVVAL-FVF------------------------CTKSRRAERYWQKTLLQMEEMES Q3U3W7_MOUSE Q3U3W7_MOUSE LLLLVIVAVLIAY------------------------KRKSRDADRTLKRLQLQMDNLES B2RXS4_MOUSE B2RXS4_MOUSE VFIIVVSI--YCY------------------------WRKSQQAEREYEKIKSQLEGLEE Q3UH76_MOUSE Q3UH76_MOUSE VFIIVVSI--YCY------------------------WRKSQQAEREYEKIKSQLEGLEE Q5RAK5_PONAB Q5RAK5_PONAB VVVIAVSV--YCY------------------------WRKSQQAEREYEKIKSQLEGLEE A6QRH2_HUMAN A6QRH2_HUMAN VVVIAVSV--YCY------------------------WRKSQQAEREYEKIKSQLEGLEE PLXB2_HUMAN PLXB2_HUMAN VVVIAVSV--YCY------------------------WRKSQQAEREYEKIKSQLEGLEE Q3LIB1_HUMAN Q3LIB1_HUMAN VVVIAVSV--YCY------------------------WRKSQQAEREYEKIKSQLEGLEE Q4T033_TETNG Q4T033_TETNG LLFIGVSV--YCYRSGQNPGDASAGARALSHAALCSDRRKSQQAEREYEKVKHQLENLEE Q5RH91_DANRE Q5RH91_DANRE VLFIAVSI--YCY------------------------RRKSQQAEREYEKIKNQLANLEE A2AFF9_MOUSE A2AFF9_MOUSE VLIAAVLLLTLMY------------------------RHKSKKALRDYQKVLVQLENLET PLXB3_MOUSE PLXB3_MOUSE VLIAAVLLLTLMY------------------------RHKSKKALRDYQKVLVQLENLET B7Z3E6_HUMAN B7Z3E6_HUMAN VLIAAVLLLTLMY------------------------RHKSKQALRDYQKVLVQLESLET A8K920_HUMAN A8K920_HUMAN VLIAAVLLLTLMY------------------------RHKSKQALRDYQKVLVQLESLET B7Z3H9_HUMAN B7Z3H9_HUMAN VLIAAVLLLTLMY------------------------RHKSKQALRDYQKVLVQLESLET PLXB3_HUMAN PLXB3_HUMAN VLIAAVLLLTLMY------------------------RHKSKQALRDYQKVLVQLESLET B0V3R5_DANRE B0V3R5_DANRE VVVLIVLVIILMY------------------------RRKSKQALRDYKKVLVQLETLEI Q4TAV0_TETNG Q4TAV0_TETNG VIILSVLVVILMY------------------------RRKSKQALRDYKKVLLQLETLEI Q4T1S7_TETNG Q4T1S7_TETNG IVALIVLIIVLIY------------------------RRKSKQAMRDYKKVQIQLENLET A6H8Y2_HUMAN A6H8Y2_HUMAN LLALGVIIIVLMY------------------------RRKSKQALRDYKKVQIQLENLES PLXB1_HUMAN PLXB1_HUMAN LLALGVIIIVLMY------------------------RRKSKQALRDYKKVQIQLENLES B2RWT9_MOUSE B2RWT9_MOUSE LLALGVIIIVLIY------------------------RRKSKQALRDYKKVQIQLENLES PLXB1_MOUSE PLXB1_MOUSE LLALGVIIIVLIY------------------------RRKSKQALRDYKKVQIQLENLES MATCH CONSENSUS ?????V?????????????????????????????????KS??A?R???K???Q?E??E?

Q5RGW1_DANRE Q5RGW1_DANRE NIRRDIRQGFVDLQTEKSDLIDNVG---AIPFLDYKHFASRIFFPE-------------- Q4RJU9_TETNG Q4RJU9_TETNG QIREEIRKGFAELQTDMTDLTKELNRSQGIPFLEYKQFVTRTFFPKLGLFASLQLGFCLT Q6DSU3_DANRE Q6DSU3_DANRE QIRDEIRKGFAELQTDMTDLTKELSRTQGIPFLEYKQFVTRTFFPK------MCCDYERR B5DE65_XENTR B5DE65_XENTR QIREEIRKGFAELQTDMTDLTKELNRSQGIPFLEYKHFVTRTFFPK------CSSLYEER Q0P4P1_XENTR Q0P4P1_XENTR ------------------------------------------------------------ PLXD1_HUMAN PLXD1_HUMAN QIREEIRKGFAELQTDMTDLTKELNRSQGIPFLEYKHFVTRTFFPK------CSSLYEER Q3UH93_MOUSE Q3UH93_MOUSE QIREEIRKGFAELQTDMTDLTKELNRSQGIPFLEYKHFVTRTFFPK------CSSLYEER Q68HV1_MOUSE Q68HV1_MOUSE QIREEIRKGFAELQTDMTDLTKELNRSQGIPFLEYKHFVTRTFFPK------CSSLYEER Q6ZQ83_MOUSE Q6ZQ83_MOUSE QIREEIRKGFAELQTDMTDLTKELNRSQGIPFLEYKHFVTRTFFPK------CSSLYEER Q3U3W7_MOUSE Q3U3W7_MOUSE RVALECKEAFAELQTDIHELTSDLDGA-GIPFLDYRTYAMRVLF---------------- B2RXS4_MOUSE B2RXS4_MOUSE SVRDRCKKEFTDLMIEMEDQTNDVHEA-GIPTLDYKTYTDRVFFLPSK------------ Q3UH76_MOUSE Q3UH76_MOUSE SVRDRCKKEFTDLMIEMEDQTNDVHEA-GIPTLDYKTYTDRVFFLPSK------------ Q5RAK5_PONAB Q5RAK5_PONAB SVRDRCKKEFTDLMIEMEDQTNDVHEA-GIPVLDYKTYTDRVFFLP----SK-------- A6QRH2_HUMAN A6QRH2_HUMAN SVRDRCKKEFTDLMIEMEDQTNDVHEA-GIPVLDYKTYTDRVFFLP-------------- PLXB2_HUMAN PLXB2_HUMAN SVRDRCKKEFTDLMIEMEDQTNDVHEA-GIPVLDYKTYTDRVFFLPSK------------ Q3LIB1_HUMAN Q3LIB1_HUMAN SVRDRCKKEFTDLMIEMEDQTNDVHEA-GIPVLDYKTCTDRVFFLP-------------- Q4T033_TETNG Q4T033_TETNG SVRDRCKKEFTDLMIEMEDHTNDLSEA-RIPFLDYKSYTDRNFFLS--SK---------- Q5RH91_DANRE Q5RH91_DANRE SVRDRCKKEFTDLMIEMEDHTSDLSEA-RIPFLDYKNYTDRVFFLP-------------- A2AFF9_MOUSE A2AFF9_MOUSE GVGDQCRKEFTDLMTEMTDLTSDLEAS-GIPFLDYRTYAERAFF---------------- PLXB3_MOUSE PLXB3_MOUSE GVGDQCRKEFTDLMTEMTDLTSDLEAS-GIPFLDYRTYAERAFF---------------- B7Z3E6_HUMAN B7Z3E6_HUMAN GVGDQCRKEFTDLMTEMTDLSSDLEGS-GIPFLDYRTYAERAFF---------------- A8K920_HUMAN A8K920_HUMAN GVGDQCRKEFTDLMTEMTDLSSDLEGS-GIPFLDYRTYAERAFF---------------- B7Z3H9_HUMAN B7Z3H9_HUMAN GVGDQCRKEFTDLMTEMTDLSSDLEGS-GIPFLDYRTYAERAFF---------------- PLXB3_HUMAN PLXB3_HUMAN GVGDQCRKEFTDLMTEMTDLSSDLEGS-GIPFLDYRTYAERAFF---------------- B0V3R5_DANRE B0V3R5_DANRE NVGDQCRKEFTDLMTEMMDLSSDVGGP-GIPFLDYRTYAERVFF---------------- Q4TAV0_TETNG Q4TAV0_TETNG NVGDQCRKEFTDLMTEMMDLSSDVGGP-GLPLLDYRTYAERVFF---------------- Q4T1S7_TETNG Q4T1S7_TETNG SVRDRCKKEFTDLMTEMMDMSSDLVGS-GIPFLDYRMYAERIFF---------------- A6H8Y2_HUMAN A6H8Y2_HUMAN SVRDRCKKEFTDLMTEMTDLTSDLLGS-GIPFLDYKVYAERIFF---------------- PLXB1_HUMAN PLXB1_HUMAN SVRDRCKKEFTDLMTEMTDLTSDLLGS-GIPFLDYKVYAERIFF---------------- B2RWT9_MOUSE B2RWT9_MOUSE SVRDRCKKEFTDLMTEMTDLTSDLLGS-GIPFLDYKVYAERFFF---------------- PLXB1_MOUSE PLXB1_MOUSE SVRDRCKKEFTDLMTEMTDLTSDLLGS-GIPFLDYKVYAERVFF---------------- MATCH CONSENSUS ???????K?F??L???M?D?????????GIP?L?Y?????R?FF????????????????

Q5RGW1_DANRE Q5RGW1_DANRE --------------AGT--------------------LTAVMI-RDIGE---DSEQTTVD Q4RJU9_TETNG Q4RJU9_TETNG VVFLLVSWELSQMCSDYERSLVQHAYENDGIAPRVLPETHPLL-QDWQAT--NATRPNVE Q6DSU3_DANRE Q6DSU3_DANRE LVQPVYENDPLGPRAHS--------------------ETHPLL-QDWQPA--GSVRPNLE B5DE65_XENTR B5DE65_XENTR YILPTQNFNTQLGFQVP--------------------ETHPLLCGEWKVP--ENCRTNME Q0P4P1_XENTR Q0P4P1_XENTR ------------------------------------------------------------ PLXD1_HUMAN PLXD1_HUMAN YVLPSQTLNSQGSSQAQ--------------------ETHPLL-GEWKIP--ESCRPNME Q3UH93_MOUSE Q3UH93_MOUSE YVLPSKTLNSQGGSPPQ--------------------ETHPLL-GEWNIP--EHCRPSME Q68HV1_MOUSE Q68HV1_MOUSE YVLPSKTLNSQGGSPPQ--------------------ETHPLL-GEWNIP--EHCRPSME Q6ZQ83_MOUSE Q6ZQ83_MOUSE YVLPSKTLNSQGGSPPQ--------------------ETHPLL-GEWNIP--EHCRPSME Q3U3W7_MOUSE Q3U3W7_MOUSE --------------PGI--------------------EDHPVL-KEMEVQ------ANVE B2RXS4_MOUSE B2RXS4_MOUSE --------------DGD--------------------KDVMIT-GKLDIP--ESRRPIVE Q3UH76_MOUSE Q3UH76_MOUSE --------------DGD--------------------KDVMIT-GKLDIP--ESRRPIVE Q5RAK5_PONAB Q5RAK5_PONAB --------------DGD--------------------KDVMIT-GKLDIP--EPRRPVVE A6QRH2_HUMAN A6QRH2_HUMAN ----------SK--DGD--------------------KDVMIT-GKLDIP--EPRRPVVE PLXB2_HUMAN PLXB2_HUMAN --------------DGD--------------------KDVMIT-GKLDIP--EPRRPVVE Q3LIB1_HUMAN Q3LIB1_HUMAN ----------SK--DGD--------------------KDVMIT-GKLDIP--EPRRPVVE Q4T033_TETNG Q4T033_TETNG --------------DGA--------------------NDAMIT-GKLQIP--EGRRAIVA Q5RH91_DANRE Q5RH91_DANRE ----------SK--DGA--------------------NDVMIT-GKLDIP--ENRRAIVD A2AFF9_MOUSE A2AFF9_MOUSE --------------PGH--------------------VGCPLQ-PGLEGLGEEGRSVTVR PLXB3_MOUSE PLXB3_MOUSE --------------PGH--------------------VGCPLQ-PGLEGLGEEGRSVTVR B7Z3E6_HUMAN B7Z3E6_HUMAN --------------PGH--------------------GGCPLQ-PKPEGPGEDGHCATVR A8K920_HUMAN A8K920_HUMAN --------------PGH--------------------GGCPLQ-PKPEGPGEDGHCATVR B7Z3H9_HUMAN B7Z3H9_HUMAN --------------PGH--------------------GGCPLQ-PKPEGPGEDGHCATVR PLXB3_HUMAN PLXB3_HUMAN --------------PGH--------------------GGCPLQ-PKPEGPGEDGHCATVR B0V3R5_DANRE B0V3R5_DANRE --------------PGQ--------------------KGAPLS-QNLDLP--DSRRQTVE Q4TAV0_TETNG Q4TAV0_TETNG --------------PGQ--------------------HVAPLT-RQLDLP--ESRRQTVE Q4T1S7_TETNG Q4T1S7_TETNG --------------PGH--------------------RESPLR-RDLDVQ--ECRRQTVE A6H8Y2_HUMAN A6H8Y2_HUMAN --------------PGH--------------------RESPLH-RDLGVP--ESRRPTVE PLXB1_HUMAN PLXB1_HUMAN --------------PGH--------------------RESPLH-RDLGVP--ESRRPTVE B2RWT9_MOUSE B2RWT9_MOUSE --------------PGY--------------------RESPLH-RDLGVP--DSRRPTVE PLXB1_MOUSE PLXB1_MOUSE --------------PGY--------------------RESPLH-RDLGVP--DSRRPTVE MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RGW1_DANRE Q5RGW1_DANRE EKCLAFAELIRDKQFLSC------------------------FVHALEEQKNFSIKDKCT Q4RJU9_TETNG Q4RJU9_TETNG EGITLFSTLLNNKHFLVT------------------------FVHALEQQKDFAVRDRCS Q6DSU3_DANRE Q6DSU3_DANRE EGITLFSTLLNNKHFLVT------------------------FVHALEQQRDFAVRDRCN B5DE65_XENTR B5DE65_XENTR EGITLLSTLLNNRHFLVT------------------------FIHAVELQKDFAVRDRCN Q0P4P1_XENTR Q0P4P1_XENTR ------------------------------------------------------------ PLXD1_HUMAN PLXD1_HUMAN EGISLFSSLLNNKHFLIV------------------------FVHALEQQKDFAVRDRCS Q3UH93_MOUSE Q3UH93_MOUSE EGISLFSSLLNNKHFLIV------------------------FVHALEQQKDFAVRDRCS Q68HV1_MOUSE Q68HV1_MOUSE EGISLFSSLLNNKHFLIV------------------------FVHALEQQKDFAVRDRCS Q6ZQ83_MOUSE Q6ZQ83_MOUSE EGISLFSSLLNNKHFLIV------------------------FVHALEQQKDFAVRDRCS Q3U3W7_MOUSE Q3U3W7_MOUSE KSLTLFGQLLTKKHFLLT------------------------FIRTLEAQRSFSMRDRGN B2RXS4_MOUSE B2RXS4_MOUSE QALYQFSNLLNSKSFLIN------------------------FIHTLENQREFSARAKVY Q3UH76_MOUSE Q3UH76_MOUSE QALYQFSNLLNSKSFLIN------------------------FIHTLENQREFSARAKVY Q5RAK5_PONAB Q5RAK5_PONAB QALYQFSNLLNSKSFLIN------------------------FIHTLENQREFSARAEVY A6QRH2_HUMAN A6QRH2_HUMAN QALYQFSNLLNSKSFLIN------------------------FIHTLENQREFSARAKVY PLXB2_HUMAN PLXB2_HUMAN QALYQFSNLLNSKSFLIN------------------------FIHTLENQREFSARAKVY Q3LIB1_HUMAN Q3LIB1_HUMAN QALYQFSNLLNSKSFLIN------------------------FIHTLENQREFSARAKVY Q4T033_TETNG Q4T033_TETNG QALNQFSNLLNSKTFLINVSLHSSPRARSLSSPFQILSSWVQFIHDPGEPAGFQRP---- Q5RH91_DANRE Q5RH91_DANRE QALNQFSNLLNSKTFLIN------------------------FIRTLEGRQEFNARNKVY A2AFF9_MOUSE A2AFF9_MOUSE QGLTQLSNLLNSKLFLLT------------------------LIHTLEEQPSFSQRDRCH PLXB3_MOUSE PLXB3_MOUSE QGLTQLSNLLNSKLFLLT------------------------LIHTLEEQPSFSQRDRCH B7Z3E6_HUMAN B7Z3E6_HUMAN QGLTQLSNLLNSKLFLLT------------------------LIHTLEEQPSFSQRDRCH A8K920_HUMAN A8K920_HUMAN QGLTQLSNLLNSKLFLLT------------------------LIHTLEEQPSFSQRDRCH B7Z3H9_HUMAN B7Z3H9_HUMAN QGLTQLSNLLNSKLFLLT------------------------LIHTLEEQPSFSQRDRCH PLXB3_HUMAN PLXB3_HUMAN QGLTQLSNLLNSKLFLLT------------------------LIHTLEEQPSFSQRDRCH B0V3R5_DANRE B0V3R5_DANRE QGLSQLNNLLNNRLFLIR------------------------FIHTLEAQQSFSQRDRGY Q4TAV0_TETNG Q4TAV0_TETNG QGLQQLNNLLNNRLFLTR------------------------FIHTLEAQQGFSQRDRGY Q4T1S7_TETNG Q4T1S7_TETNG QGLVQLSNLLNSKLFLTK------------------------FIHTLESQRTFSPRDRAY A6H8Y2_HUMAN A6H8Y2_HUMAN QGLGQLSNLLNSKLFLTK------------------------FIHTLESQRTFSARDRAY PLXB1_HUMAN PLXB1_HUMAN QGLGQLSNLLNSKLFLTK------------------------FIHTLESQRTFSARDRAY B2RWT9_MOUSE B2RWT9_MOUSE QGLGQLSNLLNSKLFLTK------------------------FIHTLESQRTFSARDRAY PLXB1_MOUSE PLXB1_MOUSE QGLGQLSNLLNSKLFLTK------------------------FIHTLESQRTFSARDRAY MATCH CONSENSUS ??????S?LLN?K?FL????????????????????????????H?LE?Q??F??R????

Q5RGW1_DANRE Q5RGW1_DANRE VASLLTLALHGDLLYLTEIMEDLLQSL---MDQSS-NAN-PKL----------------- Q4RJU9_TETNG Q4RJU9_TETNG LASLLTIALHGKLEYYTSIMKDLLVDL---IDASA-SKN-PKL----------------- Q6DSU3_DANRE Q6DSU3_DANRE LASLLTIALHGKLEYYTSIMKDLLVDL---IDASA-TKN-PKL----------------- B5DE65_XENTR B5DE65_XENTR LASHLTIALHGKLEYYTSIMKDLLVDL---IDSSA-SKN-PKL----------------- Q0P4P1_XENTR Q0P4P1_XENTR ------------------------------------EKK--------------------- PLXD1_HUMAN PLXD1_HUMAN LASLLTIALHGKLEYYTSIMKELLVDL---IDASA-AKN-PKL----------------- Q3UH93_MOUSE Q3UH93_MOUSE LASLLTIALHGKLEYYTSIMKELLVDL---IDASA-AKN-PKL----------------- Q68HV1_MOUSE Q68HV1_MOUSE LASLLTIALHGKLEYYTSIMKELLVDL---IDASA-AKN-PKL----------------- Q6ZQ83_MOUSE Q6ZQ83_MOUSE LASLLTIALHGKLEYYTSIMKELLVDL---IDASA-AKN-PKL----------------- Q3U3W7_MOUSE Q3U3W7_MOUSE VASLIMTALQGEMEYATGVLKQLLSDL---IEKNLESKNHPKL----------------- B2RXS4_MOUSE B2RXS4_MOUSE FASLLTVALHGKLEYYTDIMRTLFLEL---MEQYVVAKN-PKL----------------- Q3UH76_MOUSE Q3UH76_MOUSE FASLLTVALHGKLEYYTDIMRTLFLEL---MGQYVVAKN-PKL----------------- Q5RAK5_PONAB Q5RAK5_PONAB FASLLTVALHGKLEYYTDIMRTLFLEL---LEQYVVAKN-PKL----------------- A6QRH2_HUMAN A6QRH2_HUMAN FASLLTVALHGKLEYYTDIMHTLFLEL---LEQYVVAKN-PKL----------------- PLXB2_HUMAN PLXB2_HUMAN FASLLTVALHGKLEYYTDIMHTLFLEL---LEQYVVAKN-PKL----------------- Q3LIB1_HUMAN Q3LIB1_HUMAN FASLLTVALHGKLEYYTDIMHTLFLEL---LEQYVVAKN-PKL----------------- Q4T033_TETNG Q4T033_TETNG LSWLLRLAADGGAAREAGVLHGHHEDAAAGADGRTRAEQEPQTDAEEVEQQPLFTVGLTG Q5RH91_DANRE Q5RH91_DANRE FASLLTVALHGKLEYYTDIMRTLLLEL---MEEYVHSKN-PKL----------------- A2AFF9_MOUSE A2AFF9_MOUSE VASLLSLALHSKLEYLTDIMRTLLGDL---AAHYV-HKN-PKL----------------- PLXB3_MOUSE PLXB3_MOUSE VASLLSLALHSKLEYLTDIMRTLLGDL---AAHYV-HKN-PKL----------------- B7Z3E6_HUMAN B7Z3E6_HUMAN VASLLSLALHGKLEYLTDIMRTLLGDL---AAHYV-HRN-PKL----------------- A8K920_HUMAN A8K920_HUMAN VASLLSLALHGKLEYLTDIMRTLLGDL---AAHYV-HRN-PKL----------------- B7Z3H9_HUMAN B7Z3H9_HUMAN VASLLSLALHGKLEYLTDIMRTLLGDL---AAHYV-HRN-PKL----------------- PLXB3_HUMAN PLXB3_HUMAN VASLLSLALHGKLEYLTDIMRTLLGDL---AAHYV-HRN-PKL----------------- B0V3R5_DANRE B0V3R5_DANRE VASLLTMALHDKLEYFTDVMKNLLGDL---VQQYV-AKN-PKL----------------- Q4TAV0_TETNG Q4TAV0_TETNG VASLLTMALHDKLEYFTEVMKTLLQDL---VQQYV-AKN-PKL----------------- Q4T1S7_TETNG Q4T1S7_TETNG VASLLTVALHSKLEYFTDILKTLLNDL---VEQYV-AKN-PKL----------------- A6H8Y2_HUMAN A6H8Y2_HUMAN VASLLTVALHGKLEYFTDILRTLLSDL---VAQYV-AKN-PKL----------------- PLXB1_HUMAN PLXB1_HUMAN VASLLTVALHGKLEYFTDILRTLLSDL---VAQYV-AKN-PKL----------------- B2RWT9_MOUSE B2RWT9_MOUSE VASLLTVALHGKLEYFTDILRTLLSDL---VAQYV-AKN-PKL----------------- PLXB1_MOUSE PLXB1_MOUSE VASLLTVALHGKLEYFTDILRTLLSDL---VAQYV-AKN-PKL----------------- MATCH : CONSENSUS ?ASLL??ALHGKLEY?T?I???L???L??????????KN?PKL?????????????????

Q5RGW1_DANRE Q5RGW1_DANRE ------LLRRTESIVEKLLTNWMSICLYGFLR------------------ESVGQPLFLL Q4RJU9_TETNG Q4RJU9_TETNG ------MLRRTESVVEKMLTNWMSICMYSYLK------------------ETVGEPFFLL Q6DSU3_DANRE Q6DSU3_DANRE ------MLRRTESVVEKMLTNWMSICMYSYLK------------------ETVGEPFFLL B5DE65_XENTR B5DE65_XENTR ------MLRRTESVVEKMLTNWMSICMYSCLR------------------ETVGEPFFLL Q0P4P1_XENTR Q0P4P1_XENTR ------------------------------------------------------------ PLXD1_HUMAN PLXD1_HUMAN ------MLRRTESVVEKMLTNWMSICMYSCLR------------------ETVGEPFFLL Q3UH93_MOUSE Q3UH93_MOUSE ------MLRRTESVVEKMLTNWMSICMYGCLR------------------ETVGEPFFLL Q68HV1_MOUSE Q68HV1_MOUSE ------MLRRTESVVEKMLTNWMSICMYGCLR------------------ETVGEPFFLL Q6ZQ83_MOUSE Q6ZQ83_MOUSE ------MLRRTESVVEKMLTNWMSICMYGCLR------------------ETVGEPFFLL Q3U3W7_MOUSE Q3U3W7_MOUSE ------LLRRTESVAEKMLTNWFTFLLYKFLK------------------ECAGEPLFML B2RXS4_MOUSE B2RXS4_MOUSE ------MLRRSETVVERMLSNWMSICLYQYLK------------------DSAGEPLYKL Q3UH76_MOUSE Q3UH76_MOUSE ------MLRRSETVVERMLSNWMSICLYQYLK------------------DSAGEPLYKL Q5RAK5_PONAB Q5RAK5_PONAB ------MLRRSETVVERMLSNWMSICLYQYLK------------------DSAGEPLYKL A6QRH2_HUMAN A6QRH2_HUMAN ------MLRRSETVVERMLSNWMSICLYQYLK------------------DSAGEPLYKL PLXB2_HUMAN PLXB2_HUMAN ------MLRRSETVVERMLSNWMSICLYQYLK------------------DSAGEPLYKL Q3LIB1_HUMAN Q3LIB1_HUMAN ------MLRRSETVVERMLSNWMSICLYQYLK------------------DSAGEPLYKL Q4T033_TETNG Q4T033_TETNG RLTVASVVCRSETVVDRMLYNWMSMCLYQFLRVRNVLRVSESRTLVCGFQDTAGEPLYKL Q5RH91_DANRE Q5RH91_DANRE ------MLRRSETVVERMLCNWMSICLYQFLK------------------DSAGEPLYKL A2AFF9_MOUSE A2AFF9_MOUSE ------MLRRTETMVEKLLTNWLSICLYTFLK------------------EVAGEPLYML PLXB3_MOUSE PLXB3_MOUSE ------MLRRTETMVEKLLTNWLSICLYTFLK------------------EVAGEPLYML B7Z3E6_HUMAN B7Z3E6_HUMAN ------MLRRTETMVEKLLTNWLSICLYAFLR------------------EVAGEPLYML A8K920_HUMAN A8K920_HUMAN ------MLRRTETMVEKLLTNWLSICLYAFLR------------------EVAGEPLYML B7Z3H9_HUMAN B7Z3H9_HUMAN ------MLRRTETMVEKLLTNWLSICLYAFLR------------------EVAGEPLYML PLXB3_HUMAN PLXB3_HUMAN ------MLRRTETMVEKLLTNWLSICLYAFLR------------------EVAGEPLYML B0V3R5_DANRE B0V3R5_DANRE ------MLRRTETVVEKMLTNWMSICLYSFLK------------------EVAGEPLYKL Q4TAV0_TETNG Q4TAV0_TETNG ------MLRRTETVVEKMLTNWMSICLYSFLK------------------EVAGEPLYML Q4T1S7_TETNG Q4T1S7_TETNG ------MLRRTETVVEKLLTNWMSICLYTFLR------------------ESAGESLYML A6H8Y2_HUMAN A6H8Y2_HUMAN ------MLRRTETVVEKLLTNWMSICLYTFVR------------------DSVGEPLYML PLXB1_HUMAN PLXB1_HUMAN ------MLRRTETVVEKLLTNWMSICLYTFVR------------------DSVGEPLYML B2RWT9_MOUSE B2RWT9_MOUSE ------MLRRTETVVEKLLTNWMSICLYTFVR------------------DSVGEPLYML PLXB1_MOUSE PLXB1_MOUSE ------MLRRTETVVEKLLTNWMSICLYTFVR------------------DSVGEPLYML MATCH CONSENSUS ??????MLRR?E??VE??L?NW?SIC?Y??L??????????????????????GEP???L

Q5RGW1_DANRE Q5RGW1_DANRE VSALTQQISKGPVDSVTEKALYTLSEDWLLCQAQDFE----------------------- Q4RJU9_TETNG Q4RJU9_TETNG LCAIKQQINKGSIDAITGKARYTLNEEWLLRENVEAR----------------------- Q6DSU3_DANRE Q6DSU3_DANRE LCAIKQQINKGSIDVLTGKARYTLNEEWLLRENIEAK----------------------- B5DE65_XENTR B5DE65_XENTR LCAIKQQINKGSIDAITGKARYTLNEEWLLRENIEAK----------------------- Q0P4P1_XENTR Q0P4P1_XENTR ------------------------------------------------------------ PLXD1_HUMAN PLXD1_HUMAN LCAIKQQINKGSIDAITGKARYTLNEEWLLRENIEAK----------------------- Q3UH93_MOUSE Q3UH93_MOUSE LCAIKQQINKGSIDAITGKARYTLNEEWLLRENIEAK----------------------- Q68HV1_MOUSE Q68HV1_MOUSE LCAIKQQINKGSIDAITGKARYTLNEEWLLRENIEAK----------------------- Q6ZQ83_MOUSE Q6ZQ83_MOUSE LCAIKQQINKGSIDAITGKARYTLNEEWLLRENIEAK----------------------- Q3U3W7_MOUSE Q3U3W7_MOUSE YCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYK----------------------- B2RXS4_MOUSE B2RXS4_MOUSE FKAIKHQVEKGPVDAVQKKAKYTLNDTGLLGDDVEYA----------------------- Q3UH76_MOUSE Q3UH76_MOUSE FKAIKHQVEKGPVDAVQKKAKYTLNDTGLLGDDVEYA----------------------- Q5RAK5_PONAB Q5RAK5_PONAB FKAIKHQVEKGPVDAVQKKAKYTLNDTGLLGDDVEYA----------------------- A6QRH2_HUMAN A6QRH2_HUMAN FKAIKHQVEKGPVDAVQKKAKYTLNDTGLLGDDVEYA----------------------- PLXB2_HUMAN PLXB2_HUMAN FKAIKHQVEKGPVDAVQKKAKYTLNDTGLLGDDVEYA----------------------- Q3LIB1_HUMAN Q3LIB1_HUMAN FKAIKHQVEKGPVDAVQKKAKYTLNDTGLLGDDVEYA----------------------- Q4T033_TETNG Q4T033_TETNG FKALKHQVEKGPVDAKMKKAKYTLNDTGLLGDDVEYS----------------------- Q5RH91_DANRE Q5RH91_DANRE FKAIKHQVEKGPVDAKMKKAKYTLNDTGLLGDDVEYS----------------------- A2AFF9_MOUSE A2AFF9_MOUSE FRAIKYQVDKGPVDAVTGKAKRTLNDSHLLREDVEFQ----------------------- PLXB3_MOUSE PLXB3_MOUSE FRAIKYQVDKGPVDAVTGKAKRTLNDSHLLREDVEFQ----------------------- B7Z3E6_HUMAN B7Z3E6_HUMAN FRAIQYQVDKGPVDAVTGKAKRTLNDSRLLREDVEFQ----------------------- A8K920_HUMAN A8K920_HUMAN FRAIQYQVDKGPVDAVTGKAKRTLNDSRLLREDVEFQ----------------------- B7Z3H9_HUMAN B7Z3H9_HUMAN FRAIQYQVDKGPVDAVTGKAKRTLNDSRLLREDVEFQ----------------------- PLXB3_HUMAN PLXB3_HUMAN FRAIQYQVDKGPVDAVTGKAKRTLNDSRLLREDVEFQ----------------------- B0V3R5_DANRE B0V3R5_DANRE YRAIKYQVDKGPVDAVTGKAKRTLNDSHLLREDIDYC----------------------- Q4TAV0_TETNG Q4TAV0_TETNG YRAIKYQVDKGPVDSVTGKAKRTLNDSHLLREDIDYS----------------------- Q4T1S7_TETNG Q4T1S7_TETNG FRAIKHQVDKGPVDAVTGKAKYTLNDNRLLREDVEYRTLVIEPFFKFDPTGCCCTGIFQF A6H8Y2_HUMAN A6H8Y2_HUMAN FRGIKHQVDKGPVDSVTGKAKYTLNDNRLLREDVEYR----------------------- PLXB1_HUMAN PLXB1_HUMAN FRGIKHQVDKGPVDSVTGKAKYTLNDNRLLREDVEYR----------------------- B2RWT9_MOUSE B2RWT9_MOUSE FRGIKHQVDKGPVDSVTGKAKYTLNDNRLLREDVEYR----------------------- PLXB1_MOUSE PLXB1_MOUSE FRGIKHQVDKGPVDSVTGKAKYTLNDNRLLREDVEYR----------------------- MATCH CONSENSUS ??AIK?Q??KG??D????KA??TLN???LL????E?????????????????????????

Q5RGW1_DANRE Q5RGW1_DANRE ---PLKLKVVFAVG----TGEEISESLEVIALTCDTIQQVKEKILQTFQRKFGFRYTQQI Q4RJU9_TETNG Q4RJU9_TETNG ---PQNINVS--------FQGCGMDSLSVRVMHTDTICQVKEKIIEAFYKNLPFSQWPRA Q6DSU3_DANRE Q6DSU3_DANRE ---PQNVMVS--------FQGLGMDSVCVRVMNSDTICQVKEKILEAFYKNLPYSQWPRE B5DE65_XENTR B5DE65_XENTR ---PMNLNVS--------FQGCGMDSLCVRVLDTDTVSQCKEKILEAFCKNLPYSQWPRV Q0P4P1_XENTR Q0P4P1_XENTR ------------------------------------------------------------ PLXD1_HUMAN PLXD1_HUMAN ---PRNLNVS--------FQGCGMDSLSVRAMDTDTLTQVKEKILEAFCKNVPYSQWPRA Q3UH93_MOUSE Q3UH93_MOUSE ---PRNLNVS--------FQGCGMDSLSVRAMDTDTLTQVKEKILEAFCKNVPYSQWPRA Q68HV1_MOUSE Q68HV1_MOUSE ---PRNLNVS--------FQGCGMDSLSVRAMDTDTLTQVKEKILEAFCKNVPYSQWPRA Q6ZQ83_MOUSE Q6ZQ83_MOUSE ---PRNLNVS--------FQGCGMDSLSVRAMDTDTLTQVKEKILEAFCKNVPYSQWPRA Q3U3W7_MOUSE Q3U3W7_MOUSE ---TLTLNCVN-------PEHENAPEVPVKGLNCDTVTQVKEKLLDAVYKGVPYSQRPKA B2RXS4_MOUSE B2RXS4_MOUSE ---PLTVSVI--------VQDEGIDAIPVKVLNCDTISQVKEKIIDQVYRTQPCSCWPKP Q3UH76_MOUSE Q3UH76_MOUSE ---PLTVSVI--------VQDEGIDAIPVKVLNCDTISQVKEKIIDQVYRTQPCSCWPKP Q5RAK5_PONAB Q5RAK5_PONAB ---PLTVSVI--------VQDEGVDAIPVKVLNCDTISQVEEKIIDQVYRGQPCSCWPRP A6QRH2_HUMAN A6QRH2_HUMAN ---PLTVSVI--------VQDEGVDAIPVKVLNCDTISQVKEKIIDQVYRGQPCSCWPRP PLXB2_HUMAN PLXB2_HUMAN ---PLTVSVI--------VQDEGVDAIPVKVLNCDTISQVKEKIIDQVYRGQPCSCWPRP Q3LIB1_HUMAN Q3LIB1_HUMAN ---PLTVSVI--------VQDEGVDAIPVKVLNCDTISQVKEKIIDQVYRGQPCSCWPRP Q4T033_TETNG Q4T033_TETNG ---VLTLQVL--------VHGEGPDVTPVKVLNCDTITQVKEKVIDQVYRNMPYSQRPKV Q5RH91_DANRE Q5RH91_DANRE ---ILTLQVL--------VHGEGPDVTPVKVLNCDTISQVKEKIIEQVYRNLPYSQRPVV A2AFF9_MOUSE A2AFF9_MOUSE ---PLTLMALVGPEADRAAGNSGVHRVPARVLDTDTITQVKEKVLDQIYKGTPFSQRPSV PLXB3_MOUSE PLXB3_MOUSE ---PLTLMALVGPEADRAAGNSGVHRVPARVLDTDTITQVKEKVLDQIYKGTPFSQRPSV B7Z3E6_HUMAN B7Z3E6_HUMAN ---PLTLMVLVGPGAGGAAGSSETQRVPARVLDTDTITQVKEKVLDQVYKGTPFSQRPSV A8K920_HUMAN A8K920_HUMAN ---PLTLMVLVGPGAGGAAGSSETQRVPARVLDTDTITQVKEKVLDQVYKGTPFSQRPSV B7Z3H9_HUMAN B7Z3H9_HUMAN ---PLTLMVLVGPGAGGAAGSSEMQRVPARVLDTDTITQVKEKVLDQVYKGTPFSQRPSV PLXB3_HUMAN PLXB3_HUMAN ---PLTLMVLVGPGAGGAAGSSEMQRVPARVLDTDTITQVKEKVLDQVYKGTPFSQRPSV B0V3R5_DANRE B0V3R5_DANRE ---AVTLTVLV-------KSGVEVQPCPVKVLDIDTITQVKDKILDQIYKGAAFSQRPAA Q4TAV0_TETNG Q4TAV0_TETNG ---AMTLMV---------KNGVEVQTCPVKVLDIDTITQVKDKILDQVYRGAPFSQRPAA Q4T1S7_TETNG Q4T1S7_TETNG KLFPLILQTLNVLVQG--AGLSENQPLPTKVLDCDTITQVKEKLLDQVYKGTSFSHRPHS A6H8Y2_HUMAN A6H8Y2_HUMAN ---PLTLNALLAVG----PGAGEAQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQRPDP PLXB1_HUMAN PLXB1_HUMAN ---PLTLNALLAVG----PGAGEAQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQRPDP B2RWT9_MOUSE B2RWT9_MOUSE ---PLTLNALLAVG----PGAGEAQCVPVKVLDCDTISQAKEKMLDQLYKGVPLAQRPDS PLXB1_MOUSE PLXB1_MOUSE ---PLTLNALLAVG----PGAGEAQCVPVKVLDCDTISQAKEKMLDQLYKGVPLAQRPDS MATCH CONSENSUS ???P??????????????????????????????DT??QVKEK?????????P?S??P??

Q5RGW1_DANRE Q5RGW1_DANRE RDIEI-----------EYEKE-GKFVMLQEVDDTSEIRGHVTMLNTLKHYQVGDG-ACIK Q4RJU9_TETNG Q4RJU9_TETNG EDVDL-----------EWLDSGGNSKLLQDLDNSSVMEDGRKKLNTVFHYQVPEG-ASL- Q6DSU3_DANRE Q6DSU3_DANRE EDVEL-----------EWFPEGRSSRILQDLDDSSVMEDGRKKLNTVFHYQIPDG-ASL- B5DE65_XENTR B5DE65_XENTR EDVDL-----------EWFASSSKSYILRDLDDSSIMEDGKKKLNTLAHYKVHDG-ASL- Q0P4P1_XENTR Q0P4P1_XENTR ------------------------------------------------------------ PLXD1_HUMAN PLXD1_HUMAN EDVDL-----------EWFASSTQSYILRDLDDTSVVEDGRKKLNTLAHYKIPEG-ASL- Q3UH93_MOUSE Q3UH93_MOUSE EDVDL-----------EWFASSTQSYVLRDLDDTSVVEDGRKKLNTLAHYKIPEG-ASL- Q68HV1_MOUSE Q68HV1_MOUSE EDVDL-----------EWFASSTQSYVLRDLDDTSVVEDGRKKLNTLAHYKIPEG-ASL- Q6ZQ83_MOUSE Q6ZQ83_MOUSE EDVDL-----------EWFASSTQSYVLRDLDDTSVVEDGRKKLNTLAHYKIPEG-ASL- Q3U3W7_MOUSE Q3U3W7_MOUSE GDMDL-----------EWRQGRMARIILQDEDVTTKIDNDWKRLNTLAHYQVTDG-SSV- B2RXS4_MOUSE B2RXS4_MOUSE DSVVL-----------EWRPGSTAQ-ILSDLDLTSQREGRWKRINTLMHYNVRDG-ATL- Q3UH76_MOUSE Q3UH76_MOUSE DSVVL-----------EWRPGSTAQ-ILSDLDLTSQREGRWKRINTLMHYNVRDG-ATL- Q5RAK5_PONAB Q5RAK5_PONAB DSVVL-----------EWRPGSTAQ-ILSDLDLTSQREGRWKRVNTLMHYNVRDG-ATL- A6QRH2_HUMAN A6QRH2_HUMAN DSVVL-----------EWRPGSTAQ-ILSDLDLTSQREGRWKRVNTLMHYNVRDG-ATL- PLXB2_HUMAN PLXB2_HUMAN DSVVL-----------EWRPGSTAQ-ILSDLDLTSQREGRWKRVNTLMHYNVRDG-ATL- Q3LIB1_HUMAN Q3LIB1_HUMAN DSVVL-----------EWRPGSTAQ-VLSDLDLTSQREGRWKRVNTLMHYNVRDG-ATL- Q4T033_TETNG Q4T033_TETNG ECVAL-----------EWRPGSTGQ-ILSDLDLTSQKEGRWKKLNTLAHYNVSTHLQTFL Q5RH91_DANRE Q5RH91_DANRE DSVAL-----------EWRPGSTGQ-ILSDLDLTSQKEGRWKRINTLAHYNVRDG-ATL- A2AFF9_MOUSE A2AFF9_MOUSE HSLDL-----------EWRSGLAGHLTLSDEDLTSVTQNHWKRLNTLQHYKVPDG-ATV- PLXB3_MOUSE PLXB3_MOUSE HSLDL-----------EWRSGLAGHLTLSDEDLTSVTQNHWKRLNTLQHYKVPDG-ATV- B7Z3E6_HUMAN B7Z3E6_HUMAN HALDL-----------EWRSGLAGHLTLSDEDLTSVTQNHWKRLNTLQHYKVPDG-ATV- A8K920_HUMAN A8K920_HUMAN HALDL-----------EWRSGLAGHLTLSDEDLTSVTQNHWKRLNTLQHYKVPDG-ATV- B7Z3H9_HUMAN B7Z3H9_HUMAN HALDL-----------EWRSGLAGHLTLSDEDLTSVTQNHWKRLNTLQHYKVPDG-ATV- PLXB3_HUMAN PLXB3_HUMAN HALDL-----------EWRSGLAGHLTLSDEDLTSVTQNHWKRLNTLQHYKVPDG-ATV- B0V3R5_DANRE B0V3R5_DANRE DSLDL-----------EWRSGQAGHLTLSDDDVTAIVQGRWKRINTLQHYKVPDG-ATV- Q4TAV0_TETNG Q4TAV0_TETNG DSLDL------------------------------------------------------- Q4T1S7_TETNG Q4T1S7_TETNG DSLDLENTEKRSCFDPEWRSGVAGHLILSDEDLTSVVQGSWKRLNTLQHYKVPEG-ATV- A6H8Y2_HUMAN A6H8Y2_HUMAN RTLDV-----------EWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKVPDG-ATV- PLXB1_HUMAN PLXB1_HUMAN RTLDV-----------EWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKVPDG-ATV- B2RWT9_MOUSE B2RWT9_MOUSE CTLDV-----------EWRSGVAGHLILSDEDVTSELQGLWRRLNTLQHYKVPDG-ATV- PLXB1_MOUSE PLXB1_MOUSE CTLDV-----------EWRSGVAGHLILSDEDVTSELQGLWRRLNTLQHYKVPDG-ATV- MATCH CONSENSUS ????L???????????EW?????????L?D?D?TS?????????NTL?HY????G?A???

Q5RGW1_DANRE Q5RGW1_DANRE VITPKIHAPLKTQNS-----------------------------VKDDKNFSIKYFHLVD Q4RJU9_TETNG Q4RJU9_TETNG AMSLKDKKENTLGRV--------------------------------KDLDTEKYVHLVL Q6DSU3_DANRE Q6DSU3_DANRE AMSLKDKRENTLGRV--------------------------------KDLDTEKYVHLVL B5DE65_XENTR B5DE65_XENTR AMSLKDKRDDTLGRV--------------------------------KDLDTDKYFHLVL Q0P4P1_XENTR Q0P4P1_XENTR ------------------------------------------------------------ PLXD1_HUMAN PLXD1_HUMAN AMSLIDKKDNTLGRV--------------------------------KDLDTEKYFHLVL Q3UH93_MOUSE Q3UH93_MOUSE AMSLTDKKDSTLGRV--------------------------------KDLDTEKYFHLVL Q68HV1_MOUSE Q68HV1_MOUSE AMSLTDKKDSTLGRV--------------------------------KDLDTEKYFHLVL Q6ZQ83_MOUSE Q6ZQ83_MOUSE AMSLTDKKDSTLGRV--------------------------------KDLDTEKYFHLVL Q3U3W7_MOUSE Q3U3W7_MOUSE ALVPKQTSAYNISNSSTFTKSLSRYESMLRTASSPDSLRSRTPMITPDLESGTKLWHLVK B2RXS4_MOUSE B2RXS4_MOUSE ILSKVGVSQQPEDSQ----QDLP---------------GERHALLEEEN----RVWHLVR Q3UH76_MOUSE Q3UH76_MOUSE ILSKVGVSQQPEDSQ----QDLP---------------GERHALLEEEN----RVWHLVR Q5RAK5_PONAB Q5RAK5_PONAB ILSKVGVSQQPEDSQ----QDLP---------------GERHALLEEEN----RVWHLVR A6QRH2_HUMAN A6QRH2_HUMAN ILSKVGVSQQPEDSQ----QDLP---------------GERHALLEEEN----RVWHLVR PLXB2_HUMAN PLXB2_HUMAN ILSKVGVSQQPEDSQ----QDLP---------------GERHALLEEEN----RVWHLVR Q3LIB1_HUMAN Q3LIB1_HUMAN ILSKVGVSQQPEDSQ----QDLP---------------GERHALLEEEN----RVWHLVR Q4T033_TETNG Q4T033_TETNG ELAAGGGQHLPPGEA----GRRH---------------GRSEVQARQHEGQGHDQSH--- Q5RH91_DANRE Q5RH91_DANRE VLSRVLHTQQSFDQN----MDNH---------------EERNALLEDD-----KVFHLVR A2AFF9_MOUSE A2AFF9_MOUSE VLIPQVHNGGTVSQSLGQTGCPS---------------GENTPMLEDGEEGGVRLWHLVK PLXB3_MOUSE PLXB3_MOUSE VLIPQVHNGGTVSQSLGQTGCPS---------------GENTPMLEDGEEGGVRLWHLVK B7Z3E6_HUMAN B7Z3E6_HUMAN GLVPQLHRGSTISQSLAQ-RCPL---------------GENIPTLEDGEEGGVCLWHLVK A8K920_HUMAN A8K920_HUMAN GLVPQLHRGSTISQSLAQ-RCPL---------------GENIPTLEDGEEGGVCLWHLVK B7Z3H9_HUMAN B7Z3H9_HUMAN GLVPQLHRGSTISQSLAQ-RCPL---------------GENIPTLEDGEEGGVCLWHLVK PLXB3_HUMAN PLXB3_HUMAN GLVPQLHRGSTISQSLAQ-RCPL---------------GENIPTLEDGEEGGVCLWHLVK B0V3R5_DANRE B0V3R5_DANRE ALIPRSQSSLGVNQV-----YQT---------------GEKTPMLEGEEEEGLRLWHLVK Q4TAV0_TETNG Q4TAV0_TETNG ----------------------------------------ETPMLEGEEEEGLRLWHLVK Q4T1S7_TETNG Q4T1S7_TETNG ALVARHSKHIHHDNH----DYMA---------------GEKTPMLEDADEGGVRLWHLVK A6H8Y2_HUMAN A6H8Y2_HUMAN ALVPCLTKHVLRENQ----DYVP---------------GERTPMLEDVDEGGIRPWHLVK PLXB1_HUMAN PLXB1_HUMAN ALVPCLTKHVLRENQ----DYVP---------------GERTPMLEDVDEGGIRPWHLVK B2RWT9_MOUSE B2RWT9_MOUSE ALVPCLTKHILRENQ----DYVP---------------GERTPMLEDVDEGGIRPWHLVK PLXB1_MOUSE PLXB1_MOUSE ALVPCLTKHILRENQ----DYVP---------------GERTPMLEDVDEGGIRPWHLVK MATCH CONSENSUS ????????????????????????????????????????????????????????HLV?

Q5RGW1_DANRE Q5RGW1_DANRE PDIDTDLSN----------HPEKKALKIKEMYLIKLLSTKVAVHSFVENLFKSIWGLPNN Q4RJU9_TETNG Q4RJU9_TETNG PHDELMETRK-------SHRHSHRKKVLPEIYLTRLLSTKGTLQKFLDDLFQAILSIPLD Q6DSU3_DANRE Q6DSU3_DANRE PHDELMESRK-------THRQSQRKKVLPEIYLTRLLSTKGTLQKFLDDLFQAILSVPAE B5DE65_XENTR B5DE65_XENTR PTDDLAETKR-------SHRQSHRKKVLPEIYLTRLLSTKGTLQKFLDDLFRAILSIHED Q0P4P1_XENTR Q0P4P1_XENTR ----------------------------------------------------------KK PLXD1_HUMAN PLXD1_HUMAN PTDELAEPKK-------SHRQSHRKKVLPEIYLTRLLSTKGTLQKFLDDLFKAILSIRED Q3UH93_MOUSE Q3UH93_MOUSE PTDELVEPKK-------SHRQSHRKKVLPEIYLTRLLSTKGTLQKFLDDLFKAILSIRED Q68HV1_MOUSE Q68HV1_MOUSE PTDELVEPKK-------SHRQSHRKKVLPEIYLTRLLSTKGTLQKFLDDLFKAILSIRED Q6ZQ83_MOUSE Q6ZQ83_MOUSE PTDELVEPKK-------SHRQSHRKKVLPEIYLTRLLSTKGTLQKFLDDLFKAILSIRED Q3U3W7_MOUSE Q3U3W7_MOUSE NHDHLDQREGDRGS-----------KMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHR B2RXS4_MOUSE B2RXS4_MOUSE PTDEVDEGKSKRGSM----KEKERTKAITEIYLTRLLSVKGTLQQFVDNFFQSVLAP-GH Q3UH76_MOUSE Q3UH76_MOUSE PTDEVDEGKSKRGSM----KEKERTKAITEIYLTRLLSVKGTLQQFVDNFFQSVLAP-GH Q5RAK5_PONAB Q5RAK5_PONAB PTDEVDEGKSKRGSV----KEKERTKAITEIYLTRLLSVKGTLQQFVDNFFQSVLAP-GH A6QRH2_HUMAN A6QRH2_HUMAN PTDEVDEGKSKRGSV----KEKERTKAITEIYLTRLLSVKGTLQQFVDNFFQSVLAP-GH PLXB2_HUMAN PLXB2_HUMAN PTDEVDEGKSKRGSV----KEKERTKAITEIYLTRLLSVKGTLQQFVDNFFQSVLAP-GH Q3LIB1_HUMAN Q3LIB1_HUMAN PTDEVDEGKSKRGSV----KEKERTKAITEIYLTRLLSVKGTLQQFVDNFFQSVLAP-GH Q4T033_TETNG Q4T033_TETNG HRDLPDPAAVGQGASAPPPGRRSRLNTPLRA------PLQGTLQQFVDDFFRSVLCS-NS Q5RH91_DANRE Q5RH91_DANRE PADELEEVKSKRGSM----KDKATTKAITEIYLTRLLSMKGTLQQFVDDFFRSVLCS-GT A2AFF9_MOUSE A2AFF9_MOUSE ATEEAEGAKVRRSSLRDRERERSRAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSM-NR PLXB3_MOUSE PLXB3_MOUSE ATEEAEGAKVRRSSLRDRERERSRAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSM-NR B7Z3E6_HUMAN B7Z3E6_HUMAN ATEEPEGAKVRCSSL--REREPARAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSV-NR A8K920_HUMAN A8K920_HUMAN ATEEPEGAKVRCSSL--REREPARAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSV-NR B7Z3H9_HUMAN B7Z3H9_HUMAN ATEEPEGAKVRCSSL--REREPARAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSV-NR PLXB3_HUMAN PLXB3_HUMAN ATEEPEGAKVRCSSL--REREPARAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSV-NR B0V3R5_DANRE B0V3R5_DANRE PTEDPEIPKHRKSSM----RERERAKAIPEIYLTRLLSMKGTLQKFVDDVFVAILST-KR Q4TAV0_TETNG Q4TAV0_TETNG SSEDPDIPKHRKSSM----RDRERAKAIPEIYLTRLLSMKGTLQKFVDDVFVAILST-KR Q4T1S7_TETNG Q4T1S7_TETNG ASEEPELPKHRRGSL----RERERAKAIPEIYLTRLLSMKGTLQKFVDDLFTVILST-SR A6H8Y2_HUMAN A6H8Y2_HUMAN PSDEPEPPRPRRGSL--RGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILST-SR PLXB1_HUMAN PLXB1_HUMAN PSDEPEPPRPRRGSL--RGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILST-SR B2RWT9_MOUSE B2RWT9_MOUSE PSDEPEPPRPRRGSL--RGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILST-SR PLXB1_MOUSE PLXB1_MOUSE PSDEPEPPRPRRGSL--RGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILST-SR MATCH CONSENSUS ???????????????????????R?K???EIYLTRLLS?KGTLQ?F?D??F???L?????

Q5RGW1_DANRE Q5RGW1_DANRE --KAPLAVKYFFDFLDEQAERKKITDPDVLHIWKTN------------------------ Q4RJU9_TETNG Q4RJU9_TETNG --RPPLAVKYFFDFLEEQADKRGITDPDTLHIWKTN------------------------ Q6DSU3_DANRE Q6DSU3_DANRE --NPPLAIKYFFDFLEEQADKRGITDPDTLHIWKTN------------------------ B5DE65_XENTR B5DE65_XENTR --RPPLAIKYFFDFLEEQAEKRGISDPDTLHIWKTN------------------------ Q0P4P1_XENTR Q0P4P1_XENTR ------------------------------------------------------------ PLXD1_HUMAN PLXD1_HUMAN --KPPLAVKYFFDFLEEQAEKRGISDPDTLHIWKTN------------------------ Q3UH93_MOUSE Q3UH93_MOUSE --KPPLAVKYFFDFLEEQAEKRGISDPDTLHIWKTN------------------------ Q68HV1_MOUSE Q68HV1_MOUSE --KPPLAVKYFFDFLEEQAEKRGISDPDTLHIWKTN------------------------ Q6ZQ83_MOUSE Q6ZQ83_MOUSE --KPPLAVKYFFDFLEEQAEKRGISDPDTLHIWKTN------------------------ Q3U3W7_MOUSE Q3U3W7_MOUSE GSALPLAIKYMFDFLDEQADKHQIHDSDVRHTWKSN------------------------ B2RXS4_MOUSE B2RXS4_MOUSE --AVPPAVKYFFDFLDEQAEKHDIRDEDTIHIWKTN------------------------ Q3UH76_MOUSE Q3UH76_MOUSE --AVPPAVKYFFDFLDEQAEKHDIRDEDTIHIWKTN------------------------ Q5RAK5_PONAB Q5RAK5_PONAB --VVPPAVKYFFDFLDEQAEKHNIQDEDTIHIWKTN------------------------ A6QRH2_HUMAN A6QRH2_HUMAN --AVPPAVKYFFDFLDEQAEKHNIQDEDTIHIWKTN------------------------ PLXB2_HUMAN PLXB2_HUMAN --AVPPAVKYFFDFLDEQAEKHNIQDEDTIHIWKTN------------------------ Q3LIB1_HUMAN Q3LIB1_HUMAN --AVPPAVKYFFDFLDEQAEKHNVQDEDTIHIWKTN------------------------ Q4T033_TETNG Q4T033_TETNG --VVPPAVKYFFDFLDEQALKHDNVDEETLHIWKTNRWGLLRRARLRRLSDAGSALLGLL Q5RH91_DANRE Q5RH91_DANRE --VVPPAVKYFFDFLDEQAQKHDNVDDETIHIWKTN------------------------ A2AFF9_MOUSE A2AFF9_MOUSE --PVPIAVKYLFDFLDELAEKHGIEDPETLHIWKTN------------------------ PLXB3_MOUSE PLXB3_MOUSE --PVPIAVKYLFDFLDELAEKHGIEDPETLHIWKTN------------------------ B7Z3E6_HUMAN B7Z3E6_HUMAN --PIPIAVKYLFDLLDELAEKHGIEDPGTLHIWKTN------------------------ A8K920_HUMAN A8K920_HUMAN --PIPIAVKYLFDLLDELAEKHGIEDPGTLHIWKTN------------------------ B7Z3H9_HUMAN B7Z3H9_HUMAN --PIPIAVKYLFDLLDELAEKHGIEDPGTLHIWKTN------------------------ PLXB3_HUMAN PLXB3_HUMAN --PIPIAVKYLFDLLDELAEKHGIEDPGTLHIWKTN------------------------ B0V3R5_DANRE B0V3R5_DANRE --PPPIAVRFFFDFLDDMAEKHGIDDPETVHIWKTN------------------------ Q4TAV0_TETNG Q4TAV0_TETNG --PPPIAVRFFFDFLDDMAEKHGIDDPETVHIWKTN------------------------ Q4T1S7_TETNG Q4T1S7_TETNG --PVPLAVKYFFDLLDEQAGQHGISDSETIHIWKTN------------------------ A6H8Y2_HUMAN A6H8Y2_HUMAN --PVPLAVKYFFDLLDEQAQQHGISDQDTIHIWKTN------------------------ PLXB1_HUMAN PLXB1_HUMAN --PVPLAVKYFFDLLDEQAQQHGISDQDTIHIWKTN------------------------ B2RWT9_MOUSE B2RWT9_MOUSE --PVPLAVKYFFDLLDEQAQQHGISDQDTIHIWKTN------------------------ PLXB1_MOUSE PLXB1_MOUSE --PVPLAVKYFFDLLDEQAQQHGISDQDTIHIWKTN------------------------ MATCH CONSENSUS ????P?AVKY?FD?L?E?A????I?D??T?HIWKTN????????????????????????

Q5RGW1_DANRE Q5RGW1_DANRE SLPLRFWVNILKNPDFVFSDMEKSPHLDGCLSVIAQAFMDSFSLTDTHLDK--------- Q4RJU9_TETNG Q4RJU9_TETNG SLPLRFWVNILKNPQFVF-DIDKTDHMDACLSVIAQAFIDACSISDLQLGK--------- Q6DSU3_DANRE Q6DSU3_DANRE SLPLRFWVNILKNPQFVF-DIEKTDHMDACLSVIAQAFIDACSLSDLQLGK--------- B5DE65_XENTR B5DE65_XENTR SLPLRFWVNILKNPEFVF-DMDKSDHMDACLSVIAQAFIDACSISDMQLGK--------- Q0P4P1_XENTR Q0P4P1_XENTR ------------------------------------------------------------ PLXD1_HUMAN PLXD1_HUMAN SLPLRFWVNILKNPQFVF-DIDKTDHIDACLSVIAQAFIDACSISDLQLGK--------- Q3UH93_MOUSE Q3UH93_MOUSE SLPLRFWVNILKNPQFVF-DIEKTDHIDACLSVIAQAFIDACSISDLQLGK--------- Q68HV1_MOUSE Q68HV1_MOUSE SLPLRFWVNILKNPQFVF-DIEKTDHIDACLSVIAQAFIDACSISDLQLGK--------- Q6ZQ83_MOUSE Q6ZQ83_MOUSE SLPLRFWVNILKNPQFVF-DIEKTDHIDACLSVIAQAFIDACSISDLQLGK--------- Q3U3W7_MOUSE Q3U3W7_MOUSE CLPLRFWVNVIKNPQFVF-DIHKNSITDACLSVVAQTFMDSCSTSEHKLGK--------- B2RXS4_MOUSE B2RXS4_MOUSE SLPLRFWVNILKNPHFIF-DVHVHEVVDASLSVIAQTFMDACTRTEHKLSR--------- Q3UH76_MOUSE Q3UH76_MOUSE SLPLRFWVNILKNPHFIF-DVHVHEVVDASLSVIAQTFMDACTRTEHKLSR--------- Q5RAK5_PONAB Q5RAK5_PONAB SLPLRFWVNILKNPHFIF-DVHVHEVVDASLSVIAQTFMDACTRTEHKLSR--------- A6QRH2_HUMAN A6QRH2_HUMAN SLPLRFWVNILKNPHFIF-DVHVHEVVDASLSVIAQTFMDACTRTEHKLSR--------- PLXB2_HUMAN PLXB2_HUMAN SLPLRFWVNILKNPHFIF-DVHVHEVVDASLSVIAQTFMDACTRTEHKLSR--------- Q3LIB1_HUMAN Q3LIB1_HUMAN SLPLRFWVNILKNPHFIF-DVHVHEVVDASLSVIAQTFMDACTCTEHKLSR--------- Q4T033_TETNG Q4T033_TETNG SLPLRFWVNILKNPHFIF-DVHVTEVVEASLYVISQTLMDACTKTEHKLSR--------- Q5RH91_DANRE Q5RH91_DANRE SLPLRFWVNILKNPHFIF-DVHLTEVVDASLSVIAQTFMDACTKTEHKLTR--------- A2AFF9_MOUSE A2AFF9_MOUSE SLLLRFWVNVLKNPQLIF-DVQVSDNEDAILAVIAQTFIDSCMVSEHKVGR--------- PLXB3_MOUSE PLXB3_MOUSE SLLLRFWVNVLKNPQLIF-DVQVSDNEDAILAVIAQTFIDSCMVSEHKVGR--------- B7Z3E6_HUMAN B7Z3E6_HUMAN SLLLRFWVNALKNPQLIF-DVRVSDNVDAILAVIAQTFIDSCTTSEHKVGR--------- A8K920_HUMAN A8K920_HUMAN SLLLRFWVNALKNPQLIF-DVRVSDNVDAILAVIAQTFIDSCTTSEHKVGR--------- B7Z3H9_HUMAN B7Z3H9_HUMAN SLLLRFWVNALKNPQLIF-DVRVSDNVDAILAVIAQTFIDSCTTSEHKVGR--------- PLXB3_HUMAN PLXB3_HUMAN SLLLRFWVNALKNPQLIF-DVRVSDNVDAILAVIAQTFIDSCTTSEHKVGR--------- B0V3R5_DANRE B0V3R5_DANRE SLPLRFWVNILKNPQFVF-DVQVTDSVDPVLSVIAQTFIDSCTTSEHKVGR--------- Q4TAV0_TETNG Q4TAV0_TETNG SLPLRFWVNILKNPQFVL-DVQVSDSMDAVLSVIAQTFIDSCTTSEHKVGRSRDLKVKLL Q4T1S7_TETNG Q4T1S7_TETNG SLPLRFWINIIKNPQFIF-DVQASDHVDAVLSVIAQTFMDSCTIAEHKLGR--------- A6H8Y2_HUMAN A6H8Y2_HUMAN SLPLRFWINIIKNPQFVF-DVQTSDNMDAVLLVIAQTFMDACTLADHKLGR--------- PLXB1_HUMAN PLXB1_HUMAN SLPLRFWINIIKNPQFVF-DVQTSDNMDAVLLVIAQTFMDACTLADHKLGR--------- B2RWT9_MOUSE B2RWT9_MOUSE SLPLRFWINIIKNPQFVF-DVQTSDNMDAVLLVIAQTFMDACTLADHKLGR--------- PLXB1_MOUSE PLXB1_MOUSE SLPLRFWINIIKNPQFVF-DVQTSDNMDAVLLVIAQTFMDACTLADHKLGR--------- MATCH CONSENSUS SL?LRFWVN??KNP???F?D???????DA?L?VIAQ?F?D?C??????????????????

Q5RGW1_DANRE Q5RGW1_DANRE ---HSPTNKLLYGKDIPQYKQEVKSYYKLVKDQTSISSQELKTFLQEESK-KHQNEFNES Q4RJU9_TETNG Q4RJU9_TETNG ---DSPTNKLLYAKEIPEYKKRVQLYYQQIQEMAPLSEQEMNAHLAEESR-KYRNEFNTN Q6DSU3_DANRE Q6DSU3_DANRE ---DSPTNKLLYAKEIPEYKKRVQSFYRQIQELPALSEQEMNTHLAEESR-KHRNEFNTT B5DE65_XENTR B5DE65_XENTR ---DSPTNKLLYAKEIPEYRKIVQRYYQKIKEMSPLSEQEMNAHLAEESR-KYRNKFNTN Q0P4P1_XENTR Q0P4P1_XENTR ------------------------------------------------------------ PLXD1_HUMAN PLXD1_HUMAN ---DSPTNKLLYAKEIPEYRKIVQRYYKQIQDMTPLSEQEMNAHLAEESR-KYQNEFNTN Q3UH93_MOUSE Q3UH93_MOUSE ---DSPTNKLLYAKEIPEYRKTVQRYYKQIQDMTPLSEQEMNAHLAEESR-KYQNEFNTN Q68HV1_MOUSE Q68HV1_MOUSE ---DSPTNKLLYAKEIPEYRKTVQRYYKQIQDMTPLSEQEMNAHLAEESR-KYQNEFNTN Q6ZQ83_MOUSE Q6ZQ83_MOUSE ---DSPTNKLLYAKEIPEYRKTVQRYYKQIQDMTPLSEQEMNAHLAEESR-KYQNEFNTN Q3U3W7_MOUSE Q3U3W7_MOUSE ---DSPSNKLLYAKDIPNYKSWVERYYADIAKMPAISDQDMSAYLAEQSR-LHLSQFNSM B2RXS4_MOUSE B2RXS4_MOUSE ---DSPSNKLLYAKEISTYKKMVEDYYKGIRQMVQVSDQDMNTHLAEISR-AHTDSLNTL Q3UH76_MOUSE Q3UH76_MOUSE ---DSPSNKLLYAKEISTYKKMVEDYYKGIRQMVQVSDQDMNTHLAEISR-AHTDSLNTL Q5RAK5_PONAB Q5RAK5_PONAB ---DSPSNKLLYAKEISTYKKMVEDYYKGIRQMVQVSDQDMNTHLAEISR-AHTDSLNTL A6QRH2_HUMAN A6QRH2_HUMAN ---DSPSNKLLYAKEISTYKKMVEDYYKGIRQMVQVSDQDMNTHLAEISR-AHTDSLNTL PLXB2_HUMAN PLXB2_HUMAN ---DSPSNKLLYAKEISTYKKMVEDYYKGIRQMVQVSDQDMNTHLAEISR-AHTDSLNTL Q3LIB1_HUMAN Q3LIB1_HUMAN ---DSPSNKLLYAKEISTYKKMVEDYYKGIRQMVQVSDQDMNTHLAEISR-AHTDSLNTL Q4T033_TETNG Q4T033_TETNG ---ESPSNKLLYAKEISSYKKMVDDYCKGIRQMVSVSDQDMNTHLAELSR-QHTDKLHTQ Q5RH91_DANRE Q5RH91_DANRE ---ESPSNKLLYAKEISTYKKMVDDYYKGIRQMVPVSDQDMNTHLAEISR-SHTDKLNTQ A2AFF9_MOUSE A2AFF9_MOUSE ---DSPVNKLLYAREIPRYKQMVEKYYADIRQSSPASYQEMNSALAELSG-NYSSAPHCL PLXB3_MOUSE PLXB3_MOUSE ---DSPVNKLLYAREIPRYKQMVEKYYADIRQSSPASYQEMNSALAELSG-NYSSAPHCL B7Z3E6_HUMAN B7Z3E6_HUMAN ---DSPVNKLLYAREIPRYKQMVERYYADIRQSSPASYQEMNSALAELSG-NYTSAPHCL A8K920_HUMAN A8K920_HUMAN ---DSPVNKLLYAREIPRYKQMVERYYADIRQSSPASYQEMNSALAELSG-NYTSAPHCL B7Z3H9_HUMAN B7Z3H9_HUMAN ---DSPVNKLLYAREIPRYKQMVERYYADIRQSSPASYQEMNSALAELSG-NYTSAPHCL PLXB3_HUMAN PLXB3_HUMAN ---DSPVNKLLYAREIPRYKQMVERYYADIRQSSPASYQEMNSALAELSG-NYTSAPHCL B0V3R5_DANRE B0V3R5_DANRE ---DSPVNKLLYAREIPRYKQLVERYYSDIHNAVSGCYQEMNSMLTELSG-SFASEMNSL Q4TAV0_TETNG Q4TAV0_TETNG SNQDSPVNKLLYAREIPRYKQLVE---SDIHSAASGCYQEMNSTLTELSGQSFASEMNNL Q4T1S7_TETNG Q4T1S7_TETNG ---DSPINKLLYARDIPRYKQMVERYYADIRQTVSASDQEMNSALAELSR-NYSGELNYL A6H8Y2_HUMAN A6H8Y2_HUMAN ---DSPINKLLYARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSW-NYSGDLGAR PLXB1_HUMAN PLXB1_HUMAN ---DSPINKLLYARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSW-NYSGDLGAR B2RWT9_MOUSE B2RWT9_MOUSE ---DSPINKLLYARDIPRYKQMVERYYADIRQTVPASDQEMNSVLAELSR-NCSADLGAR PLXB1_MOUSE PLXB1_MOUSE ---DSPINKLLYARDIPRYKQMVERYYADIRQTVPASDQEMNSVLAELSR-NCSADLGAR MATCH CONSENSUS ???DSP?NKLLYA??I??YK??V??YY??I??????S?Q?MN??LAE?S???????????

Q5RGW1_DANRE Q5RGW1_DANRE AALRELYKYMQRYFTEIFQKLEQTDAPSNLKENMHRVKELFDNMKRSGWN----- Q4RJU9_TETNG Q4RJU9_TETNG LALTEIYKYAKRYRNQVVSALESNPTARRTQLH-HKFEQVIALVEDNIYECCSEA Q6DSU3_DANRE Q6DSU3_DANRE LALTEVYKYAKRYRAQVASALDSNPTARRTQLQ-HKFEQVIALVEDNIYECSSEA B5DE65_XENTR B5DE65_XENTR VAMAEIYKYAKKYRTQIVTALETNPTTKRGQLQ-HKFDQVIVLMEDDIYSCSSEA Q0P4P1_XENTR Q0P4P1_XENTR ------------------------------------------------------- PLXD1_HUMAN PLXD1_HUMAN VAMAEIYKYAKRYRPQIMAALEANPTARRTQLQ-HKFEQVVALMEDNIYECYSEA Q3UH93_MOUSE Q3UH93_MOUSE VAMAEIYKYAKRYRPQIMAALEANPTARRTQLQ-HKFEQVVALMENNIYECYSEA Q68HV1_MOUSE Q68HV1_MOUSE VAMAEIYKYAKRYRPQIMAALEANPTARRTQLQ-HKFEQVVALMENNIYECYSEA Q6ZQ83_MOUSE Q6ZQ83_MOUSE VAMAEIYKYAKRYRPQIMAALEANPTARRTQLQ-HKFEQVVALMENNIYECYSEA Q3U3W7_MOUSE Q3U3W7_MOUSE SALHEIYSYIAKYKDEILVALEKDEQARRQRLR-SKLEQVVDTMALSS------- B2RXS4_MOUSE B2RXS4_MOUSE VALHQLYQYTQKYYDEIINALEEDPAAQKMQLA-FRLQQIAAALENKVTDL---- Q3UH76_MOUSE Q3UH76_MOUSE VALHQLYQYTQKYYDEIINALEEDPAAQKMQLA-FRLQQIAAALENKVTDL---- Q5RAK5_PONAB Q5RAK5_PONAB VALHQLYQYTQKYYDEIINALEEDPAAQKMQLA-FRLQQIAAALENKVTDL---- A6QRH2_HUMAN A6QRH2_HUMAN VALHQLYQYTQKYYDEIINALEEDPAAQKMQLA-FRLQQIAAALENKVTDL---- PLXB2_HUMAN PLXB2_HUMAN VALHQLYQYTQKYYDEIINALEEDPAAQKMQLA-FRLQQIAAALENKVTDL---- Q3LIB1_HUMAN Q3LIB1_HUMAN VALHQLYQYTQKYYDEIINALEEDPAAQKMQLA-FRLQQIAAALENKVTDL---- Q4T033_TETNG Q4T033_TETNG GALHQLYQYASKYYDVIIQSLDEDPAAQNKQLT-LRLQQIAAALENKVTDL---- Q5RH91_DANRE Q5RH91_DANRE AALHQLYQYASKYYDGIISSLEEDPAAQSKQLT-LRLQQIAAALENKVTDL---- A2AFF9_MOUSE A2AFF9_MOUSE EALRELYNHIHRYYDQIISALEEDPVAQKMQLA-CRLQQVAALVEYKVTDL---- PLXB3_MOUSE PLXB3_MOUSE EALRELYNHIHRYYDQIISALEEDPVAQKMQLA-CRLQQVAALVEYKVTDL---- B7Z3E6_HUMAN B7Z3E6_HUMAN EALQELYNHIHRYYDQIISALEEDPVGQKLQLA-CRLQQVAALVENKVTDL---- A8K920_HUMAN A8K920_HUMAN EALQELYNHIHRYYDQIISALEEDPVGQKLQLA-CRLQQVAALVENKVTDL---- B7Z3H9_HUMAN B7Z3H9_HUMAN EALQELYNHIHRYYDQIISALEEDPVGQKLQLA-CRLQQVAALVENKVTDL---- PLXB3_HUMAN PLXB3_HUMAN EALQELYNHIHRYYDQIISALEEDPVGQKLQLA-CRLQQVAALVENKVTDL---- B0V3R5_DANRE B0V3R5_DANRE VALHELYKYINKYYDQIIMSLEEDAAGQKMQLA-YRLQQVAALVENKVTDL---- Q4TAV0_TETNG Q4TAV0_TETNG VALHELYKYINKYYDQIILSLDEDSSGQKMQLA-YRLQQVAALVENKVTDL---- Q4T1S7_TETNG Q4T1S7_TETNG VALHELYKYINKYYDQIITALEEDSTAQKMQLG-YRLQQIAAAVENKVTDL---- A6H8Y2_HUMAN A6H8Y2_HUMAN VALHELYKYINKYYDQIITALEEDGTAQKMQLG-YRLQQIAAAVENKVTDL---- PLXB1_HUMAN PLXB1_HUMAN VALHELYKYINKYYDQIITALEEDGTAQKMQLG-YRLQQIAAAVENKVTDL---- B2RWT9_MOUSE B2RWT9_MOUSE VALHELYKYINKYYDQIITALEEDGTAQKMQLG-YRLQQIAAAVENKVTDL---- PLXB1_MOUSE PLXB1_MOUSE VALHELYKYINKYYDQIITALEEDGTAQKMQLG-YRLQQIAAAVENKVTDL---- MATCH CONSENSUS ?AL???Y?????Y???I??ALE????????QL??????Q??A??E??????????


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