Alignment of the gene Family HBG053538 of HOVERGEN

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Threshold: 50% 80% 100%
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Isoforms are ON
Q28IZ0_XENTR Q28IZ0_XENTR MALCRVSVLGLRAARGGNQISQRLRLRSTEKRVAGDFLHQQSLLPHQTFRNAGGPAGVPG Q4S8P8_TETNG Q4S8P8_TETNG ------------------------------------------------------STGSTG Q6TEP2_DANRE Q6TEP2_DANRE FKCKTV-----WNKLAPLARASSTLCLQNARKSVLRHGRRLEMV-----QRAQMSSGPPG A2BGE5_DANRE A2BGE5_DANRE FKCKTV-----WNKLAPLARASSTLCLQNARKSVLRHGRRLEMV-----QRAQMSSGPPG Q5XFY2_DANRE Q5XFY2_DANRE FKCKTV-----WNKLAPLARASSTLCLQNARKSVLRHGRRLEMV-----QRAQMSSGPPG Q5F357_CHICK Q5F357_CHICK ------------------------------------------------------------ Q5ZHL7_CHICK Q5ZHL7_CHICK MSCCRLAAAALRP----------LSSVQRGRAAAVLQCHHLRYP-----SRALTSSGVPG Q005U5_FELCA Q005U5_FELCA ---------------------VCVRGPRQRNRLPVVQCHHLGSP-----SRSLASTGAPV A4QPB4_HUMAN A4QPB4_HUMAN FRCGGLAAGALKQKLVPLVRTVCVRSPRQRNRLPGNLFQRWHVPLELQMTRQMASSGASG AIFM1_HUMAN AIFM1_HUMAN FRCGGLAAGALKQKLVPLVRTVCVRSPRQRNRLPGNLFQRWHVPLELQMTRQMASSGASG Q8MJ23_SHEEP Q8MJ23_SHEEP ----GLAAGALKQKLVPLVRTVCVRSPRQRNRLPGNLFQRWHVPLELQMTRQMASSGASG Q2PFV8_MACFA Q2PFV8_MACFA ------------------------------------------------------------ Q2PG44_MACFA Q2PG44_MACFA ------------------------------------------------------------ AIFM1_MOUSE AIFM1_MOUSE FRCGGL-AGAFKQKLVPLVRTVYVQRPKQRNRLPGNLFQQWRVPLELQMARQMASSGSSG B1AU24_MOUSE B1AU24_MOUSE FRCGGL-AGAFKQKLVPLVRTVYVQRPKQRNRLPGNLFQQWRVPLELQMARQMASSGSSG AIFM1_RAT AIFM1_RAT FRCGGL-AGAFKQKLVPLVRSVCVQRPKQRNRLPGNLFQQWRVPLELQMARQMASSGPSG B1AU25_MOUSE B1AU25_MOUSE FRCGGL-AGAFKQKLVPLVRTVYVQRPKQRNRLPVVQCHLLGSP-----SRTLASAGASG Q924M6_RAT Q924M6_RAT FRCGGL-AGAFKQKLVPLVRSVCVQRPKQRNRLPVVQCHLLGFP-----SRSLASAGASG MATCH CONSENSUS ????????????????????????????????????????????????????????G???

Q28IZ0_XENTR Q28IZ0_XENTR PGG--DSSLYALIVGVSALGAGI-YVYRTLQGDKARFRERNSYLSRRQTDLKEEVKATE- Q4S8P8_TETNG Q4S8P8_TETNG GGEGRENLLYFAVIGTTCVGAGI-YVYRTLKQDKERYQDRINVIASRPKKAAVNEATVP- Q6TEP2_DANRE Q6TEP2_DANRE GGG--ENAVYFVLVGAACLGGGI-YAYRTVSQDSERYNERMRQIASRQSQESKPAKALAE A2BGE5_DANRE A2BGE5_DANRE GGG--ENAVYFVLVGAACLGGGI-YAYRTVSQDSERYNERMRQIASRQSQESKPAKALAE Q5XFY2_DANRE Q5XFY2_DANRE GGG--ENAVYFVLVGAACLGGGI-YAYRTVSQDSERYNERMRQIASRQSQESKPAKALA- Q5F357_CHICK Q5F357_CHICK ------------------------------------------------------------ Q5ZHL7_CHICK Q5ZHL7_CHICK KAG--SNLLLYLIVGGTVTGAGA-YVYKTLRENKERFTSRVTTVTTR------------- Q005U5_FELCA Q005U5_FELCA KDG--SSLVYFLIVGATVTGAGVYYAYKTIKDDQKRYNERMSGLGLT------------- A4QPB4_HUMAN A4QPB4_HUMAN GKI--DNSVLVLIVGLSTVGAGA-YAYKTMKEDEKRYNERISGLGLT------------- AIFM1_HUMAN AIFM1_HUMAN GKI--DNSVLVLIVGLSTVGAGA-YAYKTMKEDEKRYNERISGLGLT------------- Q8MJ23_SHEEP Q8MJ23_SHEEP GKI--DNSVLVLIVGLSTVGAGA-YAYKTMKEDEKRYNERISGLGLT------------- Q2PFV8_MACFA Q2PFV8_MACFA ------------------------------------------------------------ Q2PG44_MACFA Q2PG44_MACFA ------------------------------------------------------------ AIFM1_MOUSE AIFM1_MOUSE GKM--DNSVLVLIVGLSTIGAGA-YAYKTIKEDQKRYNERVMGLGLS------------- B1AU24_MOUSE B1AU24_MOUSE GKM--DNSVLVLIVGLSTIGAGA-YAYKTIKEDQKRYNERVMGLGLS------------- AIFM1_RAT AIFM1_RAT GKM--DNSVLVLIVGLSTIGAGA-YAYKTIKEDQKRYNERIMGLGLS------------- B1AU25_MOUSE B1AU25_MOUSE KDG--SSLVYFLIVGATVTGAGIYYAYKTIKEDQKRYNERVMGLGLS------------- Q924M6_RAT Q924M6_RAT KDG--SNLVYFLIVGATVTGAGIYYAYKTIKEDQKRYNERIMGLGLS------------- MATCH CONSENSUS ??????????????G????G?G??Y?Y?T??????R???R????????????????????

Q28IZ0_XENTR Q28IZ0_XENTR ------------------------------------------------------------ Q4S8P8_TETNG Q4S8P8_TETNG ------------------------------------------------------------ Q6TEP2_DANRE Q6TEP2_DANRE VAESKEEPVAEEPTLIEPAVEESPVTEDIVESPEAVAEPIVKSSIPEPAVEIAVTEPVVE A2BGE5_DANRE A2BGE5_DANRE VAESKEEPVAEEPTLIEPAVEESPVTEDIVESPEAVAEPIVKSSIPEPAVEIAVTEPVVE Q5XFY2_DANRE Q5XFY2_DANRE ------------------------------------------------------------ Q5F357_CHICK Q5F357_CHICK ------------------------------------------------------------ Q5ZHL7_CHICK Q5ZHL7_CHICK ------------------------------------------------------------ Q005U5_FELCA Q005U5_FELCA ------------------------------------------------------------ A4QPB4_HUMAN A4QPB4_HUMAN ------------------------------------------------------------ AIFM1_HUMAN AIFM1_HUMAN ------------------------------------------------------------ Q8MJ23_SHEEP Q8MJ23_SHEEP ------------------------------------------------------------ Q2PFV8_MACFA Q2PFV8_MACFA ------------------------------------------------------------ Q2PG44_MACFA Q2PG44_MACFA ------------------------------------------------------------ AIFM1_MOUSE AIFM1_MOUSE ------------------------------------------------------------ B1AU24_MOUSE B1AU24_MOUSE ------------------------------------------------------------ AIFM1_RAT AIFM1_RAT ------------------------------------------------------------ B1AU25_MOUSE B1AU25_MOUSE ------------------------------------------------------------ Q924M6_RAT Q924M6_RAT ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q28IZ0_XENTR Q28IZ0_XENTR ------------------------------------------------------------ Q4S8P8_TETNG Q4S8P8_TETNG ------------------------------------------------------------ Q6TEP2_DANRE Q6TEP2_DANRE ASVAESVIESPLMEPVVEASVQEPIIEATATETVAEAPEVIQSEEPIAPVVESEPVPVVS A2BGE5_DANRE A2BGE5_DANRE ASVPESVIESPLMEPVVEASVQEPIIEATATETVAEAPEVIQSEEPIAPVVESEPVPVVS Q5XFY2_DANRE Q5XFY2_DANRE ------------------------------------------------------------ Q5F357_CHICK Q5F357_CHICK ------------------------------------------------------------ Q5ZHL7_CHICK Q5ZHL7_CHICK ------------------------------------------------------------ Q005U5_FELCA Q005U5_FELCA ------------------------------------------------------------ A4QPB4_HUMAN A4QPB4_HUMAN ------------------------------------------------------------ AIFM1_HUMAN AIFM1_HUMAN ------------------------------------------------------------ Q8MJ23_SHEEP Q8MJ23_SHEEP ------------------------------------------------------------ Q2PFV8_MACFA Q2PFV8_MACFA ------------------------------------------------------------ Q2PG44_MACFA Q2PG44_MACFA ------------------------------------------------------------ AIFM1_MOUSE AIFM1_MOUSE ------------------------------------------------------------ B1AU24_MOUSE B1AU24_MOUSE ------------------------------------------------------------ AIFM1_RAT AIFM1_RAT ------------------------------------------------------------ B1AU25_MOUSE B1AU25_MOUSE ------------------------------------------------------------ Q924M6_RAT Q924M6_RAT ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q28IZ0_XENTR Q28IZ0_XENTR -TIDE-----------QKAVKEVEATGMVDNQTAPQTVESAH--------------PAQL Q4S8P8_TETNG Q4S8P8_TETNG -QPEPHAAEATETKADPETEPAAEPAAVEPSPAAPGAEAPAASSETAEPVPDSPVVEHKL Q6TEP2_DANRE Q6TEP2_DANRE TEHVPEASSVSESAAAPETSPAAAPAAEPIDPTAP---------------------HLDV A2BGE5_DANRE A2BGE5_DANRE TEHVPEASSVSESGKTPETSPAAAPAAEPIDPTAP---------------------HLDV Q5XFY2_DANRE Q5XFY2_DANRE ----------------PETCPAAAPAAEPIDPTAP---------------------HLDV Q5F357_CHICK Q5F357_CHICK ------------------------------------------------------------ Q5ZHL7_CHICK Q5ZHL7_CHICK -----------------SQEKESSPSAPEARPEVP------------------------- Q005U5_FELCA Q005U5_FELCA ----------------PEEKQKMATSPAPEGEPVP---------------------QVRV A4QPB4_HUMAN A4QPB4_HUMAN ----------------PEQKQKKAALSASEGEEVP---------------------QDKA AIFM1_HUMAN AIFM1_HUMAN ----------------PEQKQKKAALSASEGEEVP---------------------QDKA Q8MJ23_SHEEP Q8MJ23_SHEEP ----------------PEQKQKKAALSASEGEEVP---------------------QDKA Q2PFV8_MACFA Q2PFV8_MACFA ------------------------------------------------------------ Q2PG44_MACFA Q2PG44_MACFA ------------------------------------------------------------ AIFM1_MOUSE AIFM1_MOUSE ----------------PEEKQRRAIASATEGGSVP---------------------QIRA B1AU24_MOUSE B1AU24_MOUSE ----------------PEEKQRRAIASATEGGSVP---------------------QIRA AIFM1_RAT AIFM1_RAT ----------------PEEKQRRAIASAAEGGSVP---------------------PIRV B1AU25_MOUSE B1AU25_MOUSE ----------------PEEKQRRAIASATEGGSVP---------------------QIRA Q924M6_RAT Q924M6_RAT ----------------PEEKQRRAIASAAEGGSVP---------------------PIRV MATCH CONSENSUS ??????????????????????????????????P?????????????????????????

Q28IZ0_XENTR Q28IZ0_XENTR PSHVPFLLIGGGTASFAAARSIRARDPGARVLIVSDESELPYMRPPLSKELWFSEDPHVT Q4S8P8_TETNG Q4S8P8_TETNG PSHTPYLLIGGGTASFAAARSIRARDPGARVLIVTDEPDLPYMRPPLSKELWFSDDPSVT Q6TEP2_DANRE Q6TEP2_DANRE LEHAPYLLIGGGTASFAAARSIRARDPGARVLIITEESDLPYMRPPLSKELWFSDDPKVT A2BGE5_DANRE A2BGE5_DANRE LEHAPYLLIGGGTASFAAARSIRARDPGARVLIITEESDLPYMRPPLSKELWFSDDPKVT Q5XFY2_DANRE Q5XFY2_DANRE LEHAPYLLIGGGTASFAAARSIRARDPGARVLIITEESDLPYMRPPLSKELWFSDDPKVT Q5F357_CHICK Q5F357_CHICK ------------------------------------------MRPPLSKELWFSDDPHVT Q5ZHL7_CHICK Q5ZHL7_CHICK -SHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPALPYMRPPLSKELWFSDDPHVT Q005U5_FELCA Q005U5_FELCA PSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVT A4QPB4_HUMAN A4QPB4_HUMAN PSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVT AIFM1_HUMAN AIFM1_HUMAN PSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVT Q8MJ23_SHEEP Q8MJ23_SHEEP PSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVT Q2PFV8_MACFA Q2PFV8_MACFA ------------------------------------------MRPPLSKELWFSDDPNVT Q2PG44_MACFA Q2PG44_MACFA ------------------------------------------MRPPLSKELWFSDDPNVT AIFM1_MOUSE AIFM1_MOUSE PSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVT B1AU24_MOUSE B1AU24_MOUSE PSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVT AIFM1_RAT AIFM1_RAT PSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVT B1AU25_MOUSE B1AU25_MOUSE PSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVT Q924M6_RAT Q924M6_RAT PSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVT MATCH ************:** ** CONSENSUS ??H?P?LLIGGGTA?FAAARSIRARDPGARVLI??????LPYMRPPLSKELWFSDDP?VT

Q28IZ0_XENTR Q28IZ0_XENTR ETLRFKQWNGKERSIFFQPPSFYVPPEQLMSVENGGVSVLTGKKVVHMDVRENKVKLDDG Q4S8P8_TETNG Q4S8P8_TETNG ETLRFKQWNGKERSIYFQPASFYISAEELDSAENGGVAVLPGKKVVHMDVRGNKVKLDDN Q6TEP2_DANRE Q6TEP2_DANRE ESLRFKQWNGKERSIYFQPPSFYVSPADLAKVENGGVAVLTDRKVVHMDVRGNKVKLSDG A2BGE5_DANRE A2BGE5_DANRE ESLRFKQWNGKERSIYFQPPSFYVSPADLAKVENGGVAVLTDSKVVHMDVRGNKVKLSDG Q5XFY2_DANRE Q5XFY2_DANRE ESLRFKQWNGKERSIYFQPPSFYVSPADLAKVENGGVAVLTDRKVVHMDVRGNKVKLSDG Q5F357_CHICK Q5F357_CHICK ETLRFKQWNGKERSIYFQPPSFYVHARDLPFVENGGVAVLSGKKVVHMDVRGNTVKLNDG Q5ZHL7_CHICK Q5ZHL7_CHICK ETLRFKQWNGKERSIYFQPPSFYVHARDLPFVENGGVAVLSGKKVVHMDVRGNTVKLNDG Q005U5_FELCA Q005U5_FELCA KTLRFRQWNGKERSIYFQPPSFYVSAQDLPHIENGGVAVLTGKKVVQLDVRGNMVKLNDG A4QPB4_HUMAN A4QPB4_HUMAN KTLRFKQWNGKERSIYFQPPSFYVSAQDLPHIENGGVAVLTGKKVVQLDVRDNMVKLNDG AIFM1_HUMAN AIFM1_HUMAN KTLRFKQWNGKERSIYFQPPSFYVSAQDLPHIENGGVAVLTGKKVVQLDVRDNMVKLNDG Q8MJ23_SHEEP Q8MJ23_SHEEP KTLRFKQWNGKERSIYFQPPSFYVSAQDLPHIENGGVAVLTGKKVVQLDVRDNMVKLNDG Q2PFV8_MACFA Q2PFV8_MACFA KTLRFKQWNGKERSIYFQPPSFYVSAQDLPHIENGGVAVLTGKKVVQLDVRGNMVKLNDG Q2PG44_MACFA Q2PG44_MACFA KTLRFKQWNGKERSIYFQPPSFYVSAQDLPHIENGGVAVLTGKKVVQLDVRGNMVKLNDG AIFM1_MOUSE AIFM1_MOUSE KTLQFRQWNGKERSIYFQPPSFYVSAQDLPNIENGGVAVLTGKKVVHLDVRGNMVKLNDG B1AU24_MOUSE B1AU24_MOUSE KTLQFRQWNGKERSIYFQPPSFYVSAQDLPNIENGGVAVLTGKKVVHLDVRGNMVKLNDG AIFM1_RAT AIFM1_RAT KTLQFRQWNGKERSIYFQPPSFYVSAQDLPHIENGGVAVLTGKKVVHLDVRGNMVKLNDG B1AU25_MOUSE B1AU25_MOUSE KTLQFRQWNGKERSIYFQPPSFYVSAQDLPNIENGGVAVLTGKKVVHLDVRGNMVKLNDG Q924M6_RAT Q924M6_RAT KTLQFRQWNGKERSIYFQPPSFYVSAQDLPHIENGGVAVLTGKKVVHLDVRGNMVKLNDG MATCH ::*:*:*********:***.***: . :* *****:**.. ***::*** * ***.*. CONSENSUS ?TL?F?QWNGKERSIYFQPPSFYVS??DL???ENGGVAVLTGKKVV??DVR?N?VKL?DG

Q28IZ0_XENTR Q28IZ0_XENTR TQISYEKCLIATGGVPRSLPAIERAGEEVTKRTTLFRRISDFRTLEAISSSVGSITIIGG Q4S8P8_TETNG Q4S8P8_TETNG TEISYDKCLIATGGVPRNLQVIERAAEDVKSRATLFRKIEDFKSLDKVSRNIESITIIGG Q6TEP2_DANRE Q6TEP2_DANRE SEISYEKCLIATGGVPRNLQVIDRAGEEVIKRTTLFRKIEDFRSLEKISREVKSITIIGG A2BGE5_DANRE A2BGE5_DANRE SEISYEKCLIATGGVPRNLQVIDRAGEEVIKRTTLFRKIEDFRSLEKISREVKSITIIGG Q5XFY2_DANRE Q5XFY2_DANRE SEISYEKCLIATGGVPRNLQVIDRAGEEVIKRTTLFRKIEDFRSLEKISREVKSITIIGG Q5F357_CHICK Q5F357_CHICK TQISYDKCLIATGGSPRNLPAIERAGKEVQQRLTLFRKIEDFKNLEKISRQVKSITIIGG Q5ZHL7_CHICK Q5ZHL7_CHICK TQISYDKCLIATGGSPRNLPAIERAGKEVQQRLTLFRKIEDFKNLEKISRQVKSITIIGG Q005U5_FELCA Q005U5_FELCA SQITYEKCLLATGGTPRSLSAIDRAGAEVKSRTTLFRKXXXXXXXXXXXXXXXXXXXXXX A4QPB4_HUMAN A4QPB4_HUMAN SQITYEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRSLEKISREVKSITIIGG AIFM1_HUMAN AIFM1_HUMAN SQITYEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRSLEKISREVKSITIIGG Q8MJ23_SHEEP Q8MJ23_SHEEP SQITYEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRSLEKISREVKSITIIGG Q2PFV8_MACFA Q2PFV8_MACFA SQITYEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRSLEKISREVKSITIIGG Q2PG44_MACFA Q2PG44_MACFA SQITYEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRSLEKISREVKSITIIGG AIFM1_MOUSE AIFM1_MOUSE SQITFEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRALEKISREVKSITVIGG B1AU24_MOUSE B1AU24_MOUSE SQITFEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRALEKISREVKSITVIGG AIFM1_RAT AIFM1_RAT SQITFEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRALEKISREVKSITVIGG B1AU25_MOUSE B1AU25_MOUSE SQITFEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRALEKISREVKSITVIGG Q924M6_RAT Q924M6_RAT SQITFEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRALEKISREVKSITVIGG MATCH ::*:::***:**** **.* .*:**. :* .* ****: CONSENSUS ??I??EKCLIATGG?PR?L??I?RAG?EV??RTTLFRKI?DF??LEKISR?VKSIT?IGG

Q28IZ0_XENTR Q28IZ0_XENTR GFLGSELACALGRK----------------------------GTQTSLEVIQMFP-ESGN Q4S8P8_TETNG Q4S8P8_TETNG GFLGSELACALGRRCKSCSIVVYRNDAFHVTSVKPVLLLRTKANESGLEVVQMYP-EKGN Q6TEP2_DANRE Q6TEP2_DANRE GFLGSELACALGRR----------------------------SADPGLEVMQLLPRRKGN A2BGE5_DANRE A2BGE5_DANRE GFLGSELACALGRR----------------------------SADPGLEVMQLFP-EKGN Q5XFY2_DANRE Q5XFY2_DANRE GFLGSELACALGRR----------------------------SADPGLEVMQLFP-EKGN Q5F357_CHICK Q5F357_CHICK GFLGSELACALGRR----------------------------AQTRNLEVIQLFP-ENGN Q5ZHL7_CHICK Q5ZHL7_CHICK GFLGSELACALGRR----------------------------AQTRNLEVIQLFP-ENGN Q005U5_FELCA Q005U5_FELCA XXXXXXXXXXXXXX----------------------------ARALGTEVIQLFP-EKGN A4QPB4_HUMAN A4QPB4_HUMAN GFLGSELACALGRK----------------------------ARALGTEVIQLFP-EKGN AIFM1_HUMAN AIFM1_HUMAN GFLGSELACALGRK----------------------------ARALGTEVIQLFP-EKGN Q8MJ23_SHEEP Q8MJ23_SHEEP GFLGSELACALGRK----------------------------ARALGTEVIQLFP-EKGN Q2PFV8_MACFA Q2PFV8_MACFA GFLGSELACALGRK----------------------------ARALGTEVIQLFP-EKGN Q2PG44_MACFA Q2PG44_MACFA GFLGSELACALGRK----------------------------ARALGTEVIQLFP-ERGN AIFM1_MOUSE AIFM1_MOUSE GFLGSELACALGRK----------------------------SQASGIEVIQLFP-EKGN B1AU24_MOUSE B1AU24_MOUSE GFLGSELACALGRK----------------------------SQASGIEVIQLFP-EKGN AIFM1_RAT AIFM1_RAT GFLGSELACALGRK----------------------------SQASGIEVIQLFP-EKGN B1AU25_MOUSE B1AU25_MOUSE GFLGSELACALGRK----------------------------SQASGIEVIQLFP-EKGN Q924M6_RAT Q924M6_RAT GFLGSELACALGRK----------------------------SQASGIEVIQLFP-EKGN MATCH . . **:*: * . ** CONSENSUS GFLGSELACALGR?????????????????????????????????G?EV?QLFP?E?GN

Q28IZ0_XENTR Q28IZ0_XENTR MGKVLPEYLSHWTTEKVQREGVNVLSDAVVKSVSYQNGKLHIQLKDGRQVQTDHIVAAVG Q4S8P8_TETNG Q4S8P8_TETNG MGKVLPEYLSNWTTDKVKREGVKVITEALVKSVTFKDEKLEIQLKDGRKVRTDHIVAAVG Q6TEP2_DANRE Q6TEP2_DANRE MGKVLPEYLSNWTTEKVRKEGVNVITDAVVKNVTYKNDKLEIKLKDGRLVKTDHIVAAVG A2BGE5_DANRE A2BGE5_DANRE MGKVLPEYLSNWTTEKVRKEGVNVITDAVVKNVTYKNDKLEIKLKDGRLVKTDHIVAAVG Q5XFY2_DANRE Q5XFY2_DANRE MGKVLPEYLSNWTTEKVRKEGVNVITDAVVKNVTYKNDKLEIKLKDGRLVKTDHIVAAVG Q5F357_CHICK Q5F357_CHICK MGKVLPEYLSNWTTEKVRREGVNVMPNAVVKSVSVSGNRLVIKLKDGRKVETDHIVAAVG Q5ZHL7_CHICK Q5ZHL7_CHICK MGKVLPEYLSNWTTEKVRREGVNVMPNAVVKSVSVSGNRLVIKLKDGRKVETDHIVAAVG Q005U5_FELCA Q005U5_FELCA MGKILPEYLSNWTMEKVRREGVKVLPNAIVQSVGVSGGKLLIKLKDGRKVETDHIVAAVG A4QPB4_HUMAN A4QPB4_HUMAN MGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSGKLLIKLKDGRKVETDHIVAAVG AIFM1_HUMAN AIFM1_HUMAN MGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSGKLLIKLKDGRKVETDHIVAAVG Q8MJ23_SHEEP Q8MJ23_SHEEP MG---------------------------------------------------------- Q2PFV8_MACFA Q2PFV8_MACFA MGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSGKLLIKLKDGRKVETDHIVAAVG Q2PG44_MACFA Q2PG44_MACFA MGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSGKLLIKLKDGRKVETDHIVAAVG AIFM1_MOUSE AIFM1_MOUSE MGKILPQYLSNWTMEKVKREGVKVMPNAIVQSVGVSGGRLLIKLKDGRKVETDHIVTAVG B1AU24_MOUSE B1AU24_MOUSE MGKILPQYLSNWTMEKVKREGVKVMPNAIVQSVGVSGGRLLIKLKDGRKVETDHIVTAVG AIFM1_RAT AIFM1_RAT MGKILPEYLSNWTMEKVKREGVKVMPNAIVQSVGVSGGKLLIKLKDGRKVETDHIVTAVG B1AU25_MOUSE B1AU25_MOUSE MGKILPQYLSNWTMEKVKREGVKVMPNAIVQSVGVSGGRLLIKLKDGRKVETDHIVTAVG Q924M6_RAT Q924M6_RAT MGKILPEYLSNWTMEKVKREGVKVMPNAIVQSVGVSGGKLLIKLKDGRKVESDHIVTAVG MATCH ** CONSENSUS MGK?LP?YLSNWT?EKV??EGV?V???A?V??V??????L?IKLKDGR?V?TDHIV?AVG

Q28IZ0_XENTR Q28IZ0_XENTR LEPNTELAKSAGLELDGDFGGYRVNAELQARNNVWVAGDAACFYDIKLGRRRVEHHDHAV Q4S8P8_TETNG Q4S8P8_TETNG LEPNVDLAKSAGLEVDPDFGGYRVNAELQARSNIWVAGDAACFYDIRLGRRRVEHHDHAV Q6TEP2_DANRE Q6TEP2_DANRE LEPSVELAKSAGLEVDSDFGGYRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAV A2BGE5_DANRE A2BGE5_DANRE LEPSVELAKSAGLEVDSDFGGYRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAV Q5XFY2_DANRE Q5XFY2_DANRE LEPSVELAKSAGLEVDSDFGGYRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAV Q5F357_CHICK Q5F357_CHICK LEPNVELAKSAGLEVDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAV Q5ZHL7_CHICK Q5ZHL7_CHICK LEPNVELAKSAGLEVDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAV Q005U5_FELCA Q005U5_FELCA LEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVVRDAACFYDIKLGRRRVEHHDHAV A4QPB4_HUMAN A4QPB4_HUMAN LEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAV AIFM1_HUMAN AIFM1_HUMAN LEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAV Q8MJ23_SHEEP Q8MJ23_SHEEP ------------------------------------------------------------ Q2PFV8_MACFA Q2PFV8_MACFA LEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAV Q2PG44_MACFA Q2PG44_MACFA LEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAV AIFM1_MOUSE AIFM1_MOUSE LEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAV B1AU24_MOUSE B1AU24_MOUSE LEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAV AIFM1_RAT AIFM1_RAT LEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAV B1AU25_MOUSE B1AU25_MOUSE LEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAV Q924M6_RAT Q924M6_RAT LEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAV MATCH CONSENSUS LEP?VELAK??GLE?DSDFGG?RVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAV

Q28IZ0_XENTR Q28IZ0_XENTR VSGRLAGENMTGAAKPYWHQSMFWSDLGPEVGYEAIGIVDSALPTVGVFAKATEKDTPKR Q4S8P8_TETNG Q4S8P8_TETNG VSGRLAGENMTGANKPYWHQSMFWSDLGPDVGYEAIGIVDSSLPTVGVFAKATEKDTPKA Q6TEP2_DANRE Q6TEP2_DANRE VSGRLAGENMTGANKPYWHQSMFWSDLGPDVGYEAIGIVDSSLPTVGVFAKATAKDTPKA A2BGE5_DANRE A2BGE5_DANRE VSGRLAGENMTGANKPYWHQSMFWSDLGPDVGYEAIGIVDSSLPTVGVFAKATAKDTPKA Q5XFY2_DANRE Q5XFY2_DANRE VSGRLAGENMTGANKPYWHQSMFWSDLGPDVGYEAIGIVDSSLPTVGVFAKATAKDTPKA Q5F357_CHICK Q5F357_CHICK VSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSTLPTVGVFAKATAKDTPKS Q5ZHL7_CHICK Q5ZHL7_CHICK VSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSTLPTVGVFAKATAKDTPKS Q005U5_FELCA Q005U5_FELCA VSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKS A4QPB4_HUMAN A4QPB4_HUMAN VSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKS AIFM1_HUMAN AIFM1_HUMAN VSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKS Q8MJ23_SHEEP Q8MJ23_SHEEP ------------------------------------------------------------ Q2PFV8_MACFA Q2PFV8_MACFA VSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPRS Q2PG44_MACFA Q2PG44_MACFA VSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPRS AIFM1_MOUSE AIFM1_MOUSE VSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKS B1AU24_MOUSE B1AU24_MOUSE VSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKS AIFM1_RAT AIFM1_RAT VSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKS B1AU25_MOUSE B1AU25_MOUSE VSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKS Q924M6_RAT Q924M6_RAT VSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKS MATCH CONSENSUS VSGRLAGENMTGA?KPYWHQSMFWSDLGPDVGYEAIG?VDS?LPTVGVFAKATA?D?PK?

Q28IZ0_XENTR Q28IZ0_XENTR AAEESGTGIRSESEVAETGPVEEVKPPASSSEFAPSQQGDNYGKGVVFYLRDNVVVGMVL Q4S8P8_TETNG Q4S8P8_TETNG ATEKSGTGIRSESETEETATSTESSSSPAPAPEKP---KDDYGKGVIFYLRDKVVVGIIL Q6TEP2_DANRE Q6TEP2_DANRE ATEQSGTGIRSESETEAVAGVLEVGTVTPAPPV---QQKEDYGKGIIFYLRDKVVVGIVL A2BGE5_DANRE A2BGE5_DANRE ATEQSGTGIRSESETEAVAGVLEVGTVTPAPPV---QQKEDYGKGIIFYLRDKVVVGIVL Q5XFY2_DANRE Q5XFY2_DANRE ATEQSGTGIRSESETEAVAGVLEVGTVTPAPPV---QQKEDYGKGIIFYLRDKVVVGIVL Q5F357_CHICK Q5F357_CHICK ATEQSGTGIRSESETEAEASEVPISPSSSPTPQVP-KEGEDYGKGVIFYLRDKVVVGIVL Q5ZHL7_CHICK Q5ZHL7_CHICK ATEQSGTGIRSESETEAEASEVPISPSSSPTPQVP-KEGEDYGKGVIFYLRDKVVVGIVL Q005U5_FELCA Q005U5_FELCA ATEQSGTGIRSESETESEASEIAVPASSPTVPQAP-AEGEDYGKGVIFYLRDKVVVGIVL A4QPB4_HUMAN A4QPB4_HUMAN ATEQSGTGIRSESETESEASEITIPPSTPAVPQAP-VQGEDYGKGVIFYLRDKVVVGIVL AIFM1_HUMAN AIFM1_HUMAN ATEQSGTGIRSESETESEASEITIPPSTPAVPQAP-VQGEDYGKGVIFYLRDKVVVGIVL Q8MJ23_SHEEP Q8MJ23_SHEEP ------------------------------------------------------------ Q2PFV8_MACFA Q2PFV8_MACFA ATEQSGTGIRSESETESEASEIAIPPSTPAVPQAP-VQGEDYGKGVIFYLRDKVVVGIVL Q2PG44_MACFA Q2PG44_MACFA ATEQSGTGIRSESETESEASEIAIPPSTPAVPQAP-VQGEDYGKGVIFYLRDKVVVGIVL AIFM1_MOUSE AIFM1_MOUSE ATEQSGTGIRSESETESEASEITIPPSAPAVPQVP-VEGEDYGKGVIFYLRDKVVVGIVL B1AU24_MOUSE B1AU24_MOUSE ATEQSGTGIRSESETESEASEITIPPSAPAVPQVP-VEGEDYGKGVIFYLRDKVVVGIVL AIFM1_RAT AIFM1_RAT ATEQSGTGIRSESETESEASEITIPPSDPAVPQVP-VEGEDYGKGVIFYLRDKVVVGIVL B1AU25_MOUSE B1AU25_MOUSE ATEQSGTGIRSESETESEASEITIPPSAPAVPQVP-VEGEDYGKGVIFYLRDKVVVGIVL Q924M6_RAT Q924M6_RAT ATEQSGTGIRSESETESEASEITIPPSDPAVPQVP-VEGEDYGKGVIFYLRDKVVVGIVL MATCH CONSENSUS ATEQSGTGIRSESETE??A????????????P???????EDYGKG?IFYLRDKVVVGIVL

Q28IZ0_XENTR Q28IZ0_XENTR WNIFNRMPIARKIIKDGEQHSDLNEVAKLFNIHEE Q4S8P8_TETNG Q4S8P8_TETNG WNVFNRMPIARKIIKDGEEHADLNEVAKLFNIHED Q6TEP2_DANRE Q6TEP2_DANRE WNVFNRMPIARKIIKDGEAHTDLNEVAKLFNIHED A2BGE5_DANRE A2BGE5_DANRE WNVFNRMPIARKIIKDGEAHTDLNEVAKLFNIHED Q5XFY2_DANRE Q5XFY2_DANRE WNVFNRMPIARKIIKDGEAHTDLNEVAKLFNIHED Q5F357_CHICK Q5F357_CHICK WNIFNRMPIARKIIKDGEEHADLNEVAKLFNIHED Q5ZHL7_CHICK Q5ZHL7_CHICK WNIFNRMPIARKIIKDGEEHADLNEVAKLFNIHED Q005U5_FELCA Q005U5_FELCA WNIFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED A4QPB4_HUMAN A4QPB4_HUMAN WNIFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED AIFM1_HUMAN AIFM1_HUMAN WNIFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED Q8MJ23_SHEEP Q8MJ23_SHEEP ----------------------------------- Q2PFV8_MACFA Q2PFV8_MACFA WNIFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED Q2PG44_MACFA Q2PG44_MACFA WNIFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED AIFM1_MOUSE AIFM1_MOUSE WNVFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED B1AU24_MOUSE B1AU24_MOUSE WNVFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED AIFM1_RAT AIFM1_RAT WNVFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED B1AU25_MOUSE B1AU25_MOUSE WNVFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED Q924M6_RAT Q924M6_RAT WNVFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED MATCH CONSENSUS WN?FNRMPIARKIIKDGE?H?DLNEVAKLFNIHED


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