Alignment of the gene Family HBG053585 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
Q6IE91_CIOIN Q6IE91_CIOIN -----------MTSERKYSRRLPSVSCDEVNISGLGSSLNSHTPSRSRRCSEKHDLEANI JADE3_DANRE JADE3_DANRE -----------------MKRLRTPSSSD-------------------------------- JADE3_XENTR JADE3_XENTR -----------------MKRLRNLSSSD-------------------------------- B1AV39_MOUSE B1AV39_MOUSE ----------------MMKRHRPVSSSE-------------------------------- JADE3_MOUSE JADE3_MOUSE -----------------MKRHRPVSSSE-------------------------------- A8K5A5_HUMAN A8K5A5_HUMAN -----------------MKRHRPVSSSD-------------------------------- JADE3_HUMAN JADE3_HUMAN -----------------MKRHRPVSSSD-------------------------------- Q4RS29_TETNG Q4RS29_TETNG ---------MAHILARPQHRALSLLLGS-------------------------------- Q4QQY4_XENLA Q4QQY4_XENLA ---------------MEEKRRKFSLSSD-------------------------------- B5DEP9_RAT B5DEP9_RAT ---------------MEEKRRKYSISSD-------------------------------- A2AA59_MOUSE A2AA59_MOUSE ---------------MEEKRRKYSISSD-------------------------------- A2AA60_MOUSE A2AA60_MOUSE ---------------MEEKRRKYSISSD-------------------------------- JADE2_MOUSE JADE2_MOUSE ---------------MEEKRRKYSISSD-------------------------------- B5MBX1_HUMAN B5MBX1_HUMAN ---------------MEEKRRKYSISSD-------------------------------- A8K9C0_HUMAN A8K9C0_HUMAN ---------------MEEKRRKYSISSD-------------------------------- A8K356_HUMAN A8K356_HUMAN ---------------MEEKRRKYSISSD-------------------------------- B3KPL2_HUMAN B3KPL2_HUMAN VPTAAIAVGGYFLGGMEEKRRKYSISSD-------------------------------- B4DFY8_HUMAN B4DFY8_HUMAN ---------------MEEKRRKYSISSD-------------------------------- JADE2_HUMAN JADE2_HUMAN ---------------MEEKRRKYSISSD-------------------------------- Q4S6E3_TETNG Q4S6E3_TETNG -----------------MKRSRHHSSSE-------------------------------- JADE1_DANRE JADE1_DANRE -----------------MKRSRVPSTSE-------------------------------- JADE1_MOUSE JADE1_MOUSE -----------------MKRGRLPSSSE-------------------------------- JADE1_BOVIN JADE1_BOVIN -----------------MKRGRLPSSSE-------------------------------- B4DM93_HUMAN B4DM93_HUMAN -----------------MKRGRLPSSSE-------------------------------- B4E3Q3_HUMAN B4E3Q3_HUMAN ------------------------------------------------------------ B4E2E2_HUMAN B4E2E2_HUMAN -----------------MKRGRLPSSSE-------------------------------- JADE1_HUMAN JADE1_HUMAN -----------------MKRGRLPSSSE-------------------------------- A1A5F9_XENTR A1A5F9_XENTR -----------------MKRTRLLSSSE-------------------------------- JADE1_XENLA JADE1_XENLA -----------------MKRVCLPSSSE-------------------------------- MATCH CONSENSUS ??????????????????KR?????SS?????????????????????????????????

Q6IE91_CIOIN Q6IE91_CIOIN DENRTDGDDNNNNNRSASAYLSKLLDCKDLLNDLDASPSPG-----------NPELEANG JADE3_DANRE JADE3_DANRE -----SSDNE---------------SPSTSFSSNKYGSKPG-----------TPA----- JADE3_XENTR JADE3_XENTR -----SSDNESP---S---------TSFSSCFQ--HKGKGK-----------CTA----- B1AV39_MOUSE B1AV39_MOUSE -----SSDECPS-------------TSFTSSSM--YRKKSK-----------NPK----- JADE3_MOUSE JADE3_MOUSE -----SSDECPS-------------TSFTSSSM--YRKKSK-----------NPK----- A8K5A5_HUMAN A8K5A5_HUMAN -----SSDESPS-------------TSFTSGSM--YRIKSK-----------IPN----- JADE3_HUMAN JADE3_HUMAN -----SSDESPS-------------TSFTSGSM--YRIKSK-----------IPN----- Q4RS29_TETNG Q4RS29_TETNG -----TCESTGS-------------PVGDQSALIPTSGTSTFYPAGTSFQLLCER----- Q4QQY4_XENLA Q4QQY4_XENLA -----DSDTTDSHMTS------------SRGSKVP-ATKTT-----------WTR----- B5DEP9_RAT B5DEP9_RAT -----NSDTTDGHVTS---------TSASRCSKLPSSTKSG-----------WPR----- A2AA59_MOUSE A2AA59_MOUSE -----NSDTTDGHVTS---------TSASRCSKLPSSTKSG-----------WPR----- A2AA60_MOUSE A2AA60_MOUSE -----NSDTTDGHVTS---------TSASRCSKLPSSTKSG-----------WPR----- JADE2_MOUSE JADE2_MOUSE -----NSDTTDGHVTS---------TSASRCSKLPSSTKSG-----------WPR----- B5MBX1_HUMAN B5MBX1_HUMAN -----NSDTTDSHATS---------TSASRCSKLPSSTKSG-----------WPR----- A8K9C0_HUMAN A8K9C0_HUMAN -----NSDTTDSHATS---------TSASRCSKLPSSTKSG-----------WPR----- A8K356_HUMAN A8K356_HUMAN -----NSDTTDSHATS---------TSASRCSKLPSSTKSG-----------WPR----- B3KPL2_HUMAN B3KPL2_HUMAN -----NSDTTDSHATS---------TSASRCSKLPSSTKSG-----------WPR----- B4DFY8_HUMAN B4DFY8_HUMAN -----NSDTTDSHATS---------TSASRCSKLPSSTKSG-----------WPR----- JADE2_HUMAN JADE2_HUMAN -----NSDTTDSHATS---------TSASRCSKLPSSTKSG-----------WPR----- Q4S6E3_TETNG Q4S6E3_TETNG -----DSDNGSS---S---------TCWSQHSTQPRR----------------------- JADE1_DANRE JADE1_DANRE -----DSD-NGS--NS---------TSWSQHSNSKHR-----------------K----- JADE1_MOUSE JADE1_MOUSE -----DSDDNGS--LS---------TTWSQHSRSQHGRSST-----------CSR----- JADE1_BOVIN JADE1_BOVIN -----DSDDNGS--LS---------TTWSQNSRSQHRRSS------------CSR----- B4DM93_HUMAN B4DM93_HUMAN -----DSDDNGS--LS---------TTWSQNSRSQHRRSS------------CSR----- B4E3Q3_HUMAN B4E3Q3_HUMAN ------------------------------------------------------------ B4E2E2_HUMAN B4E2E2_HUMAN -----DSDDNGS--LS---------TTWSQNSRSQHRRSS------------CSR----- JADE1_HUMAN JADE1_HUMAN -----DSDDNGS--LS---------TTWSQNSRSQHRRSS------------CSR----- A1A5F9_XENTR A1A5F9_XENTR -----DSDNNDS--LS---------TSWSQHSR---SRPSG-----------SLR----- JADE1_XENLA JADE1_XENLA -----DSDDNGS--LS---------TSWSQHSR---SLPSF-------------R----- MATCH CONSENSUS ??????SD?????????????????T?????S????????????????????????????

Q6IE91_CIOIN Q6IE91_CIOIN FTYNSLKPSTPSTSNMRSAIQRSTSLSQKRQSRIPNRHKPAEIFRKDLISAMKIPDTSQL JADE3_DANRE JADE3_DANRE ----------------------------------SAQKKPAEVFRKDLISAMKLPDSHHI JADE3_XENTR JADE3_XENTR ----------------------------------DDGKKSAEVFRKDLISAMKIPDSQHV B1AV39_MOUSE B1AV39_MOUSE -----------------------------------EQKKSAEVFRKDLISAMKIPDSHHV JADE3_MOUSE JADE3_MOUSE ----------------------------------EQK-KSAEVFRKDLISAMKIPDSHHV A8K5A5_HUMAN A8K5A5_HUMAN -----------------------------------EHKKPAEVFRKDLISAMKLPDSHHI JADE3_HUMAN JADE3_HUMAN -----------------------------------EHKKPAEVFRKDLISAMKLPDSHHI Q4RS29_TETNG Q4RS29_TETNG ----------------------------------GEEFSP---FFPPLLGPLTQSRYWQR Q4QQY4_XENLA Q4QQY4_XENLA ----------------------------------QKEKKPSEVFRTDLITAMKVPDSFQF B5DEP9_RAT B5DEP9_RAT ----------------------------------QNEKKPSEVFRTDLITAMKIPDSYQL A2AA59_MOUSE A2AA59_MOUSE ----------------------------------QNEKKPSEVFRTDLITAMKIPDSYQL A2AA60_MOUSE A2AA60_MOUSE ----------------------------------QNEKKPSEVFRTDLITAMKIPDSYQL JADE2_MOUSE JADE2_MOUSE ----------------------------------QNEKKPSEVFRTDLITAMKIPDSYQL B5MBX1_HUMAN B5MBX1_HUMAN ----------------------------------QNEKKPSEVFRTDLITAMKIPDSYQL A8K9C0_HUMAN A8K9C0_HUMAN ----------------------------------QNEKKPSEVFRTDLITAMKIPDSYQL A8K356_HUMAN A8K356_HUMAN ----------------------------------QNEKKPSEVFRTDLITAMKIPDSYQL B3KPL2_HUMAN B3KPL2_HUMAN ----------------------------------QNEKKPSEVFRTDLITAMKIPDSYQL B4DFY8_HUMAN B4DFY8_HUMAN ----------------------------------QNEKKPSEVFRTDLITAMKIPDSYQL JADE2_HUMAN JADE2_HUMAN ----------------------------------QNEKKPSEVFRTDLITAMKIPDSYQL Q4S6E3_TETNG Q4S6E3_TETNG ----------------------------------SAGQKPSEVFRTDLITAMKVHDSYQL JADE1_DANRE JADE1_DANRE ----------------------------------QSGKRPSEVFRTDLITAMKLHDSHQL JADE1_MOUSE JADE1_MOUSE ----------------------------------PEDRKPSEVFRTDLITAMKLHDSYQL JADE1_BOVIN JADE1_BOVIN ----------------------------------PEDRKPSEVFRTDLITAMKLHDSYQL B4DM93_HUMAN B4DM93_HUMAN ----------------------------------HEDRKPSEVFRTDLITAMKLHDSYQL B4E3Q3_HUMAN B4E3Q3_HUMAN ----------------------------------MGERGPG------------------- B4E2E2_HUMAN B4E2E2_HUMAN ----------------------------------HEDRKPSEVFRTDLITAMKLHDSYQL JADE1_HUMAN JADE1_HUMAN ----------------------------------HEDRKPSEVFRTDLITAMKLHDSYQL A1A5F9_XENTR A1A5F9_XENTR ----------------------------------HEDRKPSEVFRTDLITAMKLHDSYQL JADE1_XENLA JADE1_XENLA ----------------------------------HEDRKPSEVFRTDLITAMKLHDSNQL MATCH . CONSENSUS ??????????????????????????????????????KP?EVFR?DLI?AMK??DS???

Q6IE91_CIOIN Q6IE91_CIOIN LNEEYWIMQDPWRIEWEKGVQVPVN-AKSVPTKNIQIVPK-ETLGDFRMPRK-MLKSSPD JADE3_DANRE JADE3_DANRE SSEDYYLLADTWKQEWEKGVQVLAS-PDTIPQPSVRIITEKPKEVLFSKPRKYIQCWSQD JADE3_XENTR JADE3_XENTR NPEEYYQFADTWKQEWEKGVQVPSN-PENIPQPSLRVIAEKAKEVLFTRPRKYIHCSSQE B1AV39_MOUSE B1AV39_MOUSE NPDSYYLFTDTWKEEWEKGVQVPAN-PDSVPTPSLRIISEKVKEMLFVRPRKYIRCSSPE JADE3_MOUSE JADE3_MOUSE NPDSYYLFTDTWKEEWEKGVQVPAN-PDSVPTPSLRIISEKVKEMLFVRPRKYIRCSSPE A8K5A5_HUMAN A8K5A5_HUMAN NPDSYYLFADTWREEWEKGVQVPAS-PDTVPQPSLRIIAEEVKDVLFIRPRKYIHCSSPD JADE3_HUMAN JADE3_HUMAN NPDSYYLFADTWKEEWEKGVQVPAS-PDTVPQPSLRIIAEKVKDVLFIRPRKYIHCSSPD Q4RS29_TETNG Q4RS29_TETNG NHPSVYRCV--FLNRINGGTNISENFSKFSKTDSNRADVGRERRRAEAWSQRQPVSGAKA Q4QQY4_XENLA Q4QQY4_XENLA GPDEFYILADPWRQEWEKGVQVPAS-LGTVPQPEVRFVHDIEDCPPLITPHS--LGETEY B5DEP9_RAT B5DEP9_RAT SPDDYYILADPWRQEWEKGVQVPAG-AEAIPEPVVRILPPLKGPPTLMSPESPTLGEGAH A2AA59_MOUSE A2AA59_MOUSE SPDDYYILADPWRQEWEKGVQVPAG-AEAIPEPVVRLLPPLKGPPTQMSPDSPTLGEGAH A2AA60_MOUSE A2AA60_MOUSE SPDDYYILADPWRQEWEKGVQVPAG-AEAIPEPVVRLLPPLKGPPTQMSPDSPTLGEGAH JADE2_MOUSE JADE2_MOUSE SPDDYYILADPWRQEWEKGVQVPAG-AEAIPEPVVRLLPPLKGPPTQMSPDSPTLGEGAH B5MBX1_HUMAN B5MBX1_HUMAN SPDDYYILADPWRQEWEKGVQVPAG-AEAIPEPVVRILPPLEGPPAQASPSSTMLGEGSQ A8K9C0_HUMAN A8K9C0_HUMAN SPDDYYILADPWRQEWEKGVQVPAG-AEAIPEPVVRILPPLEGPPAQASPSSTMLGEGSQ A8K356_HUMAN A8K356_HUMAN SPDDYYILADPWRQEWEKGVQVPAG-AEAIPEPVVRILPPLEGPPAQASPSSTMLGEGSQ B3KPL2_HUMAN B3KPL2_HUMAN SPDDYYILADPWRQEWEKGVQVPAG-AEAIPEPVVRILPPLEGPPAQASPSSTMLGEGSQ B4DFY8_HUMAN B4DFY8_HUMAN SPDDYYILADPWRQEWEKGVQVPAG-AEAIPEPVVRILPPLEGPPAQASPSSTMLGEGSQ JADE2_HUMAN JADE2_HUMAN SPDDYYILADPWRQEWEKGVQVPAG-AEAIPEPVVRILPPLEGPPAQASPSSTMLGEGSQ Q4S6E3_TETNG Q4S6E3_TETNG NPEDYYVLADPWRQEWEKGVQVPVS-PQSIPQPVVRTLAEKEKEVMFVRPKKLIRTSGAE JADE1_DANRE JADE1_DANRE NPEDYYELADPWRQEWEKGVQVPVS-PESIPQCAVRTVAEKSTAPLFIKPKKLIRS--SE JADE1_MOUSE JADE1_MOUSE NPDDYYVLADPWRQEWEKGVQVPVS-PGTIPQPVARVVSE-EKSLMFIRPKKYIASSGSE JADE1_BOVIN JADE1_BOVIN NPDEYYVLADPWRQEWEKGVQVPVS-PGTIPQPVARVVSE-EKSLMFIRPKKYIVSSGSE B4DM93_HUMAN B4DM93_HUMAN NPDEYYVLADPWRQEWEKGVQVPVS-PGTIPQPVARVVSE-EKSLMFIRPKKYIVSSGSE B4E3Q3_HUMAN B4E3Q3_HUMAN ----------------------ACE-PGVVSE---------EKSLMFIRPKKYIVSSGSE B4E2E2_HUMAN B4E2E2_HUMAN NPDEYYVLADPWRQEWEKGVQVPVS-PGTIPQPVPGVVSE-EKSLMFIRPKKYIVSSGSE JADE1_HUMAN JADE1_HUMAN NPDEYYVLADPWRQEWEKGVQVPVS-PGTIPQPVARVVSE-EKSLMFIRPKKYIVSSGSE A1A5F9_XENTR A1A5F9_XENTR NPEDFYVLADPWRQEWEKGVQVPVN-PEFIPETVAREIAEKDKVVTFTRPRKYIRSSGSE JADE1_XENLA JADE1_XENLA NPEDYYVLADPWRQEWEKGVQVPVN-PEFIPETIARVIAEKDKVVTFTRPRKYIHSSGSE MATCH . CONSENSUS ?P??YY??AD?W??EWEKGVQVP???????P????R?????????????P??????????

Q6IE91_CIOIN Q6IE91_CIOIN I-----GDRDMIDLNVLADST-------------------CRYDLDEMDVAWLKIINHER JADE3_DANRE JADE3_DANRE S-----TETGYVNIKELAEAM-------------------CRYDLDDMDLYWLQQLNAEL JADE3_XENTR JADE3_XENTR P-----AEPGYINILELAESM-------------------CRYDLDDLDLYWLGECNLEL B1AV39_MOUSE B1AV39_MOUSE S-----AEPGYINTLEQAAST-------------------CRYDLDDMDIFWLQELNEDL JADE3_MOUSE JADE3_MOUSE S-----AEPGYINTLEQAAST-------------------CRYDLDDMDIFWLQELNEDL A8K5A5_HUMAN A8K5A5_HUMAN T-----TEPGYINIMELAASV-------------------CRYDLDDMDIFWLQELNEDL JADE3_HUMAN JADE3_HUMAN T-----TEPGYINIMELAASV-------------------CRYDLDDMDIFWLQELNEDL Q4RS29_TETNG Q4RS29_TETNG S-----ANANCSGAEELLPALASEAAGRPERRSSGRPAPFCCYDLDDLDVAWLELVNHEF Q4QQY4_XENLA Q4QQY4_XENLA PRRFQTPFRSS-----------------------------CRYDLDEIDTCWLELVNMEF B5DEP9_RAT B5DEP9_RAT P-----DWPGG-----------------------------SRYDLDEIDAYWLELLNSEL A2AA59_MOUSE A2AA59_MOUSE P-----DWPGG-----------------------------SRYDLDEIDAYWLELLNSEL A2AA60_MOUSE A2AA60_MOUSE P-----DWPGG-----------------------------SRYDLDEIDAYWLELLNSEL JADE2_MOUSE JADE2_MOUSE P-----DWPGG-----------------------------SRYDLDEIDAYWLELLNSEL B5MBX1_HUMAN B5MBX1_HUMAN P-----DWPGG-----------------------------SRYDLDEIDAYWLELINSEL A8K9C0_HUMAN A8K9C0_HUMAN P-----DWPEG-----------------------------SRYDLDEIDAYWLELINSEL A8K356_HUMAN A8K356_HUMAN P-----DWPGG-----------------------------SRYDLDEIDAYWLELINSEL B3KPL2_HUMAN B3KPL2_HUMAN P-----DWPGG-----------------------------SRYDLDEIDAYWLELINSEL B4DFY8_HUMAN B4DFY8_HUMAN P-----DWPGG-----------------------------SRYDLDEIDAYWLELINSEL JADE2_HUMAN JADE2_HUMAN P-----DWPGG-----------------------------SRYDLDEIDAYWLELINSEL Q4S6E3_TETNG Q4S6E3_TETNG A-------LGYVDIRTLAEGM-------------------CRYDLNEQDVAWLQIANKQF JADE1_DANRE JADE1_DANRE S-----SMLGYVGIQTLADGM-------------------CRYDLNEEDVAWLQITNEEF JADE1_MOUSE JADE1_MOUSE P-----PALGYVDIRTLADSV-------------------CRYDLNDMDAAWLEVTNEEF JADE1_BOVIN JADE1_BOVIN P-----PELGYVDIRTLADSV-------------------CRYDLNDMDAAWLELTNEEF B4DM93_HUMAN B4DM93_HUMAN P-----PELGYVDIRTLADSV-------------------CRYDLNDMDAAWLELTNEEF B4E3Q3_HUMAN B4E3Q3_HUMAN P-----PELGYVDIRTLADSV-------------------CRYDLNDMDAAWLELTNEEF B4E2E2_HUMAN B4E2E2_HUMAN P-----PELGYVDIRTLADSV-------------------CRYDLNDMDAAWLELTNEEF JADE1_HUMAN JADE1_HUMAN P-----PELGYVDIRTLADSV-------------------CRYDLNDMDAAWLELTNEEF A1A5F9_XENTR A1A5F9_XENTR P-----PELGYVDIQTLADAV-------------------CRYDLDEMDVAWLELINEEF JADE1_XENLA JADE1_XENLA P-----PEVGYVDIQTLADAV-------------------CRYDLNEMDVAWLQLINEEF MATCH . ***:: * ** * : CONSENSUS ?????????G???????????????????????????????RYDL???D??WL???N?E?

Q6IE91_CIOIN Q6IE91_CIOIN KMMGLATLDEFSMEQIMEELETQCHDNMQLAIKTKEGLGIEYDEDVVCDVCRIPDCEEGN JADE3_DANRE JADE3_DANRE GMMGDGVVDELTMERVMEALERQCHENMNHAIETEEGLGIEYDEDVICDVCRSPDSEEGN JADE3_XENTR JADE3_XENTR ADMGCAPVDESTMEKTLEVLERQCHENMNHAIETEEGLGIEYDEDVICDVCRSPDSEEGN B1AV39_MOUSE B1AV39_MOUSE GEMGYGPIDETLMEKTIEVLERHCHENMNHAIETVEGLGIEYDEDVICDVCRSPDSEEGN JADE3_MOUSE JADE3_MOUSE GEMGYGPIDETLMEKTIEVLERHCHENMNHAIETVEGLGIEYDEDVICDVCRSPDSEEGN A8K5A5_HUMAN A8K5A5_HUMAN AEMGCGPVDENLMEKTVEVLERHCHENMNHAIETEEGLGIEYDEDVICDVCRSPDSEEGN JADE3_HUMAN JADE3_HUMAN AEMGCGPVDENLMEKTVEVLERHCHENMNHAIETEEGLGIEYDEDVICDVCRSPDSEEGN Q4RS29_TETNG Q4RS29_TETNG RQMALPELDELTMECVLVELESACEEKMRQAIETEEGLGIEYDEDVVCDVCRSPEGEDGN Q4QQY4_XENLA Q4QQY4_XENLA KEIGLPELDELTLERVLEEMEILCFENMNVAIETEEGLGIEYDEDVVCDVCRSPEGEDGN B5DEP9_RAT B5DEP9_RAT KEMEKPELDELTLERVLEELETLCHQNMAQAIETQEGLGIEYDEDVVCDVCRSPEGEDGN A2AA59_MOUSE A2AA59_MOUSE KEMEKPELDELTLERVLEELETLCHQNMAQAIETQEGLGIEYDEDVVCDVCRSPEGEDGN A2AA60_MOUSE A2AA60_MOUSE KEMEKPELDELTLERVLEELETLCHQNMAQAIETQEGLGIEYDEDVVCDVCRSPEGEDGN JADE2_MOUSE JADE2_MOUSE KEMEKPELDELTLERVLEELETLCHQNMAQAIETQEGLGIEYDEDVVCDVCRSPEGEDGN B5MBX1_HUMAN B5MBX1_HUMAN KEMERPELDELTLERVLEELETLCHQNMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGN A8K9C0_HUMAN A8K9C0_HUMAN KEMERPELDELTLERVLEELETLCHQNMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGN A8K356_HUMAN A8K356_HUMAN KEMERPELDELTLERVLEELETLCHQNMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGN B3KPL2_HUMAN B3KPL2_HUMAN KEMERPELDELTLERVLEELETLCHQNMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGN B4DFY8_HUMAN B4DFY8_HUMAN KEMERPELDELTLERVLEELETLCHQNMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGN JADE2_HUMAN JADE2_HUMAN KEMERPELDELTLERVLEELETLCHQNMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGN Q4S6E3_TETNG Q4S6E3_TETNG AEMALPPLDEITMERVMEEFERRCHENMTHAMETEEGLGIEYDEDVVCDVCQSPDGEDNN JADE1_DANRE JADE1_DANRE SKMGMQPLDELTMERVMEEFERRCYDNMSHAMETEEGLGIEYDEDVVCDVCQSPDGEDGN JADE1_MOUSE JADE1_MOUSE KEMGMPELDEYTMERVLEEFEQRCYDNMNHAIETEEGLGIEYDEDVVCDVCQSPDGEDGN JADE1_BOVIN JADE1_BOVIN KEMGMPELDEYTMERVLEEFEQRCYDNMNHAIETEEGLGIEYDEYVVCDVCQSPDGEDGN B4DM93_HUMAN B4DM93_HUMAN KEMGMPELDEYTMERVLEEFEQRCYDNMNHAIETEEGLGIEYDEDVVCDVCQSPDGEDGN B4E3Q3_HUMAN B4E3Q3_HUMAN KEMGMPELDEYTMERVLEEFEQRCYDNMNHAIETEEGLGIEYDEDVVCDVCQSPDGEDGN B4E2E2_HUMAN B4E2E2_HUMAN KEMGMPELDEYTMERVLEEFEQRCYDNMNHAIETEEGLGIEYDEDVVCDVCQSPDGEDGN JADE1_HUMAN JADE1_HUMAN KEMGMPELDEYTMERVLEEFEQRCYDNMNHAIETEEGLGIEYDEDVVCDVCQSPDGEDGN A1A5F9_XENTR A1A5F9_XENTR KEMGMQQLDEYSMERVLEEFEKKCYDKMNHAIETEEGLGIEYDEDVVCDVCQSPDGEDGN JADE1_XENLA JADE1_XENLA KEMGMQQLDEYTMEQVLEEFEKKCYDKMNHAIETEEGLGIEYDEDVVCDVCQSPDGEDGN MATCH : :** :* : :* * ::* *::* ********* *:****: *: *:.* CONSENSUS ?EM?????DE???E???E??E??C??NM??AIET?EGLGIEYDEDV?CDVC?SP??E?GN

Q6IE91_CIOIN Q6IE91_CIOIN EMVFCDGCNLCVHQACYGILKVPVGSWLCKPCALGIRGSAMCILCNKKGGAMKSTRSGNK JADE3_DANRE JADE3_DANRE DMVFCDKCNICVHQACYGIVKVPDGNWLCRTCVLGIT--PQCLLCPKTGGAMKATRAGTK JADE3_XENTR JADE3_XENTR DMVFCDRCNICVHQACYGILKVPEGSWLCRTCVLGLH--PQCILCPKTGGAMKATRTGTK B1AV39_MOUSE B1AV39_MOUSE DMVFCDKCNVCVHQACYGILKIPEGSWLCRSCVLGIY--PQCVLCPKKGGAMKTTRTGTK JADE3_MOUSE JADE3_MOUSE DMVFCDKCNVCVHQACYGILKIPEGSWLCRSCVLGIY--PQCVLCPKKGGAMKTTRTGTK A8K5A5_HUMAN A8K5A5_HUMAN DMVFCDKCNVCVHQACYGILKVPEGSWLCRSCVLGIY--PQCVLCPKKGGALKTTKTGTK JADE3_HUMAN JADE3_HUMAN DMVFCDKCNVCVHQACYGILKVPEGSWLCRSCVLGIY--PQCVLCPKKGGALKTTKTGTK Q4RS29_TETNG Q4RS29_TETNG EMVFCDKCNVCVHQACYGILKVPRGNWLCRTCALGVQ--PKCLLCPKRGGALKPTRSGTK Q4QQY4_XENLA Q4QQY4_XENLA EMVFCDKCNVCVHQACYGILNVPTGSWLCRCCALGVQ--AKCLLCPKRGGALKPTRSGTK B5DEP9_RAT B5DEP9_RAT EMVFCDKCNVCVHQACYGILKVPTGSWLCRTCALGVQ--PKCLLCPKRGGALKPTRSGTK A2AA59_MOUSE A2AA59_MOUSE EMVFCDKCNVCVHQACYGILKVPTGSWLCRTCALGVQ--PKCLLCPKRGGALKPTRSGTK A2AA60_MOUSE A2AA60_MOUSE EMVFCDKCNVCVHQACYGILKVPTGSWLCRTCALGVQ--PKCLLCPKRGGALKPTRSGTK JADE2_MOUSE JADE2_MOUSE EMVFCDKCNVCVHQACYGILKVPTGSWLCRTCALGVQ--PKCLLCPKRGGALKPTRSGTK B5MBX1_HUMAN B5MBX1_HUMAN EMVFCDKCNVCVHQACYGILKVPTGSWLCRTCALGVQ--PKCLLCPKRGGALKPTRSGTK A8K9C0_HUMAN A8K9C0_HUMAN EMVFCDKCNVCVHQACYGILKVPTGSWLCRTCALGVQ--PKCLLCPKRGGALKPTRSGTK A8K356_HUMAN A8K356_HUMAN EMVFCDKCNVCVHQACYGILKVPTGSWLCRTCALGVQ--PKCLLCPKRGGALKPTRSGTK B3KPL2_HUMAN B3KPL2_HUMAN EMVFCDKCNVCVHQACYGILKVPTGSWLCRTCALGVQ--PKCLLCPKRGGALKPTRSGTK B4DFY8_HUMAN B4DFY8_HUMAN EMVFCDKCNVCVHQACYGILKVPTGSWLCRTCALGVQ--PKCLLCPKRGGALKPTRSGTK JADE2_HUMAN JADE2_HUMAN EMVFCDKCNVCVHQACYGILKVPTGSWLCRTCALGVQ--PKCLLCPKRGGALKPTRSGTK Q4S6E3_TETNG Q4S6E3_TETNG EMVFCDKCNICVHQACYGIQKVPKGSWLCRICALGIL--PKCQLCPKKGGAME---ADPE JADE1_DANRE JADE1_DANRE EMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGIF--PKCHLCPKKGGAMKPTRSGTK JADE1_MOUSE JADE1_MOUSE EMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGVQ--PKCLLCPKKGGAMKPTRSGTK JADE1_BOVIN JADE1_BOVIN EMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGVQ--PKCLLCPKKGGAMKPTRSGTK B4DM93_HUMAN B4DM93_HUMAN EMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGVQ--PKCLLCPKKGGAMKPTRSGTK B4E3Q3_HUMAN B4E3Q3_HUMAN EMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGVQ--PKCLLCPKKGGAMKPTRSGTK B4E2E2_HUMAN B4E2E2_HUMAN EMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGVQ--PKCLLCPKKGGAMKPTRSGTK JADE1_HUMAN JADE1_HUMAN EMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGVQ--PKCLLCPKKGGAMKPTRSGTK A1A5F9_XENTR A1A5F9_XENTR EMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGVQ--PKCLLCPKKGGAMKPTRSGTK JADE1_XENLA JADE1_XENLA EMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGVQ--PKCLLCPKKGGAMKPTRSGTK MATCH :***** **:********* ::* *.***: *.**: . * ** * ***:: :. : CONSENSUS ?MVFCDKCN?CVHQACYGILKVP?GSWLCR?C?LG????P?C?LCPK?GGA?K?TR?GTK

Q6IE91_CIOIN Q6IE91_CIOIN WAHVSCALWIPEITIADPDRMEPITKVSHVPSSRWALLCSICKDRVGACIQCSVRHCVTA JADE3_DANRE JADE3_DANRE WAHVSCALWIPEVSIACPERMEPITKVSHIPPSRWSLICSLCKLKTGACIQCSVKNCTIP JADE3_XENTR JADE3_XENTR WAHVSCALWIPEVSIACPERMEPITKVSHIPPSRWALVCSLCKLKTGACIQCSVKSCITA B1AV39_MOUSE B1AV39_MOUSE WAHVSCALWIPEVSIACPERMEPVTKISHIPPSRWALVCNLCKLKTGACIQCSVKSCITA JADE3_MOUSE JADE3_MOUSE WAHVSCALWIPEVSIACPERMEPVTKISHIPPSRWALVCNLCKLKTGACIQCSVKSCITA A8K5A5_HUMAN A8K5A5_HUMAN WAHVSCALWIPEVSIACPERMEPITKISHIPPSRWALVCNLCKLKTGACIQCSIKSCITA JADE3_HUMAN JADE3_HUMAN WAHVSCALWIPEVSIACPERMEPITKISHIPPSRWALVCNLCKLKTGACIQCSIKSCITA Q4RS29_TETNG Q4RS29_TETNG WVHVSCALWIPEVSIGCPEKMEPITKVSHIPASRWALSCSLCREHTGTCIQCSMPSCIVA Q4QQY4_XENLA Q4QQY4_XENLA WVHVSCALWIPEVSIGCPEKMEPITKISHIPPSRWALSCSLCRECTGTCIQCSMPSCITA B5DEP9_RAT B5DEP9_RAT WVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSTPSCLTA A2AA59_MOUSE A2AA59_MOUSE WVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCITA A2AA60_MOUSE A2AA60_MOUSE WVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCITA JADE2_MOUSE JADE2_MOUSE WVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCITA B5MBX1_HUMAN B5MBX1_HUMAN WVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCVTA A8K9C0_HUMAN A8K9C0_HUMAN WVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCVTA A8K356_HUMAN A8K356_HUMAN WVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCVTA B3KPL2_HUMAN B3KPL2_HUMAN WVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCVTA B4DFY8_HUMAN B4DFY8_HUMAN WVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCVTA JADE2_HUMAN JADE2_HUMAN WVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCVTA Q4S6E3_TETNG Q4S6E3_TETNG W---------NQVSIGNPEKMEPITNVSQIPSNRWALVCCLCKEKTGACIQCSAKNCRTA JADE1_DANRE JADE1_DANRE WVHVSCALWIPEVSIGNPEKMEPITNVSHIPSNRWALICCLCKEKTGACIQCSAKSCRVA JADE1_MOUSE JADE1_MOUSE WVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNEKFGASIQCSVKNCRTA JADE1_BOVIN JADE1_BOVIN WVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNEKFGASIQCSVKNCRTA B4DM93_HUMAN B4DM93_HUMAN WVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNEKFGASIQCSVKNCRTA B4E3Q3_HUMAN B4E3Q3_HUMAN WVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNEKFGASIQCSVKNCRTA B4E2E2_HUMAN B4E2E2_HUMAN WVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNEKFGASIQCSVKNCRTA JADE1_HUMAN JADE1_HUMAN WVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNEKFGASIQCSVKNCRTA A1A5F9_XENTR A1A5F9_XENTR WVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALFCSLCNEKLGACIQCSIKNCRTA JADE1_XENLA JADE1_XENLA WVHVSCALWIPEVSIGSPEKMEPITKVSHIPSNRWALLCSLCNEKVGACIQCSIKNCRTA MATCH * :::*. *::***:*::*::*..**:* * :*. *:.**** * . CONSENSUS W?HVSCALWIPEVSI??PE?MEPITK?SHIP?SRWAL?C?LC????G??IQCS???C?TA

Q6IE91_CIOIN Q6IE91_CIOIN YHVTCAIEDKLDMIADCGVSPLEGQEDAVIFRSYCKKHS-----------------TNRK JADE3_DANRE JADE3_DANRE FHVTCAFEHSLEM------KTILDEGDEVKFKSYCLKHS--------------------K JADE3_XENTR JADE3_XENTR FHVTCAFEHSLEM------KTILDEGDEVKFKSYCLKHS--------------------K B1AV39_MOUSE B1AV39_MOUSE FHVTCAFEHGLEM------KTILDEGDEVKFKSFCLKHS------------------QNK JADE3_MOUSE JADE3_MOUSE FHVTCAFEHGLEM------KTILDEGDEVKFKSFCLKHS------------------QNK A8K5A5_HUMAN A8K5A5_HUMAN FHVTCAFEHGLEM------KTILDEGDEVKFKSYCLKHS------------------QNR JADE3_HUMAN JADE3_HUMAN FHVTCAFEHGLEM------KTILDEGDEVKFKSYCLKHS------------------QNR Q4RS29_TETNG Q4RS29_TETNG FHVTCAFDHSLEM------RTILAENDEVRFKSFCLEHS------CTASNSAPGLAGVSN Q4QQY4_XENLA Q4QQY4_XENLA FHVTCAFDHNLEM------HTTLSENDEVKFKSFCLEHS--------------SRTNKAE B5DEP9_RAT B5DEP9_RAT FHVTCAFDRGLEM------RTILADNDEVKFKSLCQEHS--------------------- A2AA59_MOUSE A2AA59_MOUSE FHVTCAFDRGLEM------RTILADNDEVKFKSLCQEHS--------------------- A2AA60_MOUSE A2AA60_MOUSE FHVTCAFDRGLEM------RTILADNDEVKFKSLCQEHS--------------------- JADE2_MOUSE JADE2_MOUSE FHVTCAFDRGLEM------RTILADNDEVKFKSLCQEHS--------------------- B5MBX1_HUMAN B5MBX1_HUMAN FHVTCAFDHGLEM------RTILADNDEVKFKSFCQEHS--------------------- A8K9C0_HUMAN A8K9C0_HUMAN FHVTCAFDHGLEM------RTISADNDEVKFKSFCQEHS--------------------- A8K356_HUMAN A8K356_HUMAN FHVTCAFDHGLEM------RTILADNDEVKFKSFCQEHS--------------------- B3KPL2_HUMAN B3KPL2_HUMAN FHVTCAFDHGLEM------RTILADNDEVKFKSFCQEHS--------------------- B4DFY8_HUMAN B4DFY8_HUMAN FHVTCAFDHGLEM------RTILADNDEVKFKSFCQEHS--------------------- JADE2_HUMAN JADE2_HUMAN FHVTCAFDHGLEM------RTILADNDEVKFKSFCQEHS--------------------- Q4S6E3_TETNG Q4S6E3_TETNG FHVTCGLHASLRM------KTILTEDDEVKFKSYCPKHSGLDGAQVRDSGGEEESARDKK JADE1_DANRE JADE1_DANRE FHVTCGLHCGLKM------NTILTEADEVKFKSFCPKHS----------------GLDWN JADE1_MOUSE JADE1_MOUSE FHVTCAFDRGLEM------KTILAENDEVKFKSYCPKHS-----------------SHRK JADE1_BOVIN JADE1_BOVIN FHVTCAFDRGLEM------KTILAENDEVKFKSYCPKHS-----------------SHRK B4DM93_HUMAN B4DM93_HUMAN FHVTCAFDRGLEM------KTILAENDEVKFKSYCPKHS-----------------SHRK B4E3Q3_HUMAN B4E3Q3_HUMAN FHVTCAFDRGLEM------KTILAENDEVKFKSYCPKHS-----------------SHRK B4E2E2_HUMAN B4E2E2_HUMAN FHVTCAFDRGLEM------KTILAENDEVKFKSYCPKHS-----------------SHRK JADE1_HUMAN JADE1_HUMAN FHVTCAFDRGLEM------KTILAENDEVKFKSYCPKHS-----------------SHRK A1A5F9_XENTR A1A5F9_XENTR FHVTCAFDHGLEM------KTILTEEDEVKFKSYCPKHG-----------------STKK JADE1_XENLA JADE1_XENLA FHVTCAFDHGLEM------KTILTQEDEVKFKSYCPKHG-----------------STKK MATCH :****.:. * * . : * * *:* * :*. CONSENSUS FHVTCAF???LEM???????TIL???DEVKFKS?C??HS?????????????????????

Q6IE91_CIOIN Q6IE91_CIOIN ESDG-------------E-----------------------------DEQTEERIRGMRH JADE3_DANRE JADE3_DANRE PKAG----------------EPGLSPARH------------------KPPTETDKLSLRA JADE3_XENTR JADE3_XENTR NKHGLIS----------EQEEPHKTHSD-------------------NRPTESERTSLRA B1AV39_MOUSE B1AV39_MOUSE PKLG-------------DAEYHHHRVAE-------------------QSQAKSEKTSLRA JADE3_MOUSE JADE3_MOUSE PKLG-------------DAEYHHHRVAE-------------------QSQAKSEKTSLRA A8K5A5_HUMAN A8K5A5_HUMAN QKLG-------------EAEYPHHRAKE-------------------QSQAKSEKTSLRA JADE3_HUMAN JADE3_HUMAN QKLG-------------EAEYPHHRAKE-------------------QSQAKSEKTSLRA Q4RS29_TETNG Q4RS29_TETNG GNHGLPVTKGAQASAHDQASAAGCMALRPDGEQRSLSAAE-------RDQLEREKVSLRK Q4QQY4_XENLA Q4QQY4_XENLA DQRG-------------QRPSSSVAQVEVD-----------------QTKQDLEKATLRK B5DEP9_RAT B5DEP9_RAT -DGG-------------PRSEPSSEPVEPS-----------------QAVEDLEKVTLRK A2AA59_MOUSE A2AA59_MOUSE -DGG-------------PRSEPTSEPVEPS-----------------QAVEDLEKVTLRK A2AA60_MOUSE A2AA60_MOUSE -DGG-------------PRSEPTSEPVEPS-----------------QAVEDLEKVTLRK JADE2_MOUSE JADE2_MOUSE -DGG-------------PRSEPTSEPVEPS-----------------QAVEDLEKVTLRK B5MBX1_HUMAN B5MBX1_HUMAN -DGG-------------PRNEPTSEPTEPS-----------------QAGEDLEKVTLRK A8K9C0_HUMAN A8K9C0_HUMAN -DGG-------------PRNEPTSEPTEPS-----------------QAGEDLEKVTLRK A8K356_HUMAN A8K356_HUMAN -DGG-------------PRNEPTSEPTEPS-----------------QAGEDLEKVTLRK B3KPL2_HUMAN B3KPL2_HUMAN -DGG-------------PRNEPTSEPTEPS-----------------QAGEDLEKVTLRK B4DFY8_HUMAN B4DFY8_HUMAN -DGG-------------PRNEPTSEPTEPS-----------------QAGEDLEKVTLRK JADE2_HUMAN JADE2_HUMAN -DGG-------------PRNEPTSEPTEPS-----------------QAGEDLEKVTLRK Q4S6E3_TETNG Q4S6E3_TETNG RRTGRTRGEEEEEEEEEEEEEEEEEEAAPASLASQVSSRTSGAADALSSHQQEKRVNLRK JADE1_DANRE JADE1_DANRE EEEG-------------DDDRPVKVPTREDRSRNRGIDFSASSQTRLSQNPEETRLSERK JADE1_MOUSE JADE1_MOUSE PEEG-LGEGAAQ-----ENGAPESSPQSPLEPYGSLE----------PNREEAHRVSVRK JADE1_BOVIN JADE1_BOVIN AEEG-LGEGTAQ-----ENGAPECSPRDPLEPFAGLE----------QNREEAHRVSVRK B4DM93_HUMAN B4DM93_HUMAN PEES-LGKGAAQ-----ENGAPECSPRNPLEPFASLE----------QNREEAHRVSVRK B4E3Q3_HUMAN B4E3Q3_HUMAN PEES-LGKGAAQ-----ENGAPECSPRNPLELFASLE----------QNREEAHRVSVRK B4E2E2_HUMAN B4E2E2_HUMAN PEES-LGKGAAQ-----ENGAPECSPRNPLEPFASLE----------QNREEAHRVSVRK JADE1_HUMAN JADE1_HUMAN PEES-LGKGAAQ-----ENGAPECSPRNPLEPFASLE----------QNREEAHRVSVRK A1A5F9_XENTR A1A5F9_XENTR PENSHFCKSVND-----GKGTCGASPTCLDGLRLLD-----------VSQQDAKHGSQRK JADE1_XENLA JADE1_XENLA PEDSHFCRSASD-----GKDTCEASP-TFLGGLRVLE----------ASQQNVKHGSQRK MATCH . . * CONSENSUS ??????????????????????????????????????????????????????????R?

Q6IE91_CIOIN Q6IE91_CIOIN RRIMELEQEFYTLVKYQAVANALSIPSQTARDVMEYWKLKRAANFNRPLITPKHEEGTAL JADE3_DANRE JADE3_DANRE QKLQELEEEFYTYVHPEEVAHDLSLPLHLLDFIFQYWKMKRKSNFNKALLPPKEDEENLL JADE3_XENTR JADE3_XENTR QKLKELEEDFYTLVKVEDVAAELGLPMLTVDFIYSFWKLKRKSNFNKPLLTPKEDEQNGL B1AV39_MOUSE B1AV39_MOUSE QKLRELEEEFYTLVQVEDVAKEMELSAFTVDFIYNYWKLKRKSNFNKPLIPPKEEEENGL JADE3_MOUSE JADE3_MOUSE QKLRELEEEFYTLVQVEDVAKEMELSAFTVDFIYNYWKLKRKSNFNKPLIPPKEEEENGL A8K5A5_HUMAN A8K5A5_HUMAN QKLRELEEEFYSLVRVEDVAAELGMPTLAVDFIYNYWKLKRKSNFNKPLFPPKEDEENGL JADE3_HUMAN JADE3_HUMAN QKLRELEEEFYSLVRVEDVAAELGMPTLAVDFIYNYWKLKRKSNFNKPLFPPKEDEENGL Q4RS29_TETNG Q4RS29_TETNG QKLQELEDEFYRLVDPREVADNLELPVFQVDFLYQFWKLKRKSNFNRPLVTLKRDEVDNL Q4QQY4_XENLA Q4QQY4_XENLA QKLMELEDDFHELVKPEDVAENLDMKKNLVDFIYQYWKLKRKSNFNKPLLIPKTDEVDNL B5DEP9_RAT B5DEP9_RAT QRLQQLEENFYELVEPAEVAERLDLAEALVDFIYQYWKLKRRANANQPLLTPKTDEVDNL A2AA59_MOUSE A2AA59_MOUSE QRLQQLEENFYELVEPAEVAERLDLAEALVDFIYQYWKLKRRANANQPLLTPKTDEVDNL A2AA60_MOUSE A2AA60_MOUSE QRLQQLEENFYELVEPAEVAERLDLAEALVDFIYQYWKLKRRANANQPLLTPKTDEVDNL JADE2_MOUSE JADE2_MOUSE QRLQQLEENFYELVEPAEVAERLDLAEALVDFIYQYWKLKRRANANQPLLTPKTDEVDNL B5MBX1_HUMAN B5MBX1_HUMAN QRLQQLEEDFYELVEPAEVAERLDLAEALVDFIYQYWKLKRKANANQPLLTPKTDEVDNL A8K9C0_HUMAN A8K9C0_HUMAN QRLQQLEEDFYELVEPAEVAERLDLAEALVDFIYQYWKLKRKANANQPLLTPKTDEVDNL A8K356_HUMAN A8K356_HUMAN QRLQQLEEDFYELVGPAEVAERLDLAEALVDFIYQYWKLKRKANANQPLLTPKTDEVDNL B3KPL2_HUMAN B3KPL2_HUMAN QRLQQLEEDFYELVEPAEVAERLDLAEALVDFIYQYWKLKRKANANQPLLTPKTDEVDNL B4DFY8_HUMAN B4DFY8_HUMAN QRLQQLEEDFYELVEPAEVAERLDLAEALVDFIYQYWKLKRKANANQPLLTPKTDEVDNL JADE2_HUMAN JADE2_HUMAN QRLQQLEEDFYELVEPAEVAERLDLAEALVDFIYQYWKLKRKANANQPLLTPKTDEVDNL Q4S6E3_TETNG Q4S6E3_TETNG LKLEAMEEEFYRFVQAEEVARHLKLSPEPADFLYQYWKLRRKANFNQPLLTPKKDEEDSL JADE1_DANRE JADE1_DANRE LRVQQLEDEFYRFVAADEVAEHLQLPLEMVDILFQYWKLKRKVNFNQPLIMPKKEEEDSL JADE1_MOUSE JADE1_MOUSE QKLQQLEDEFYTFVNLLDVARALRLPEEVVDFLYQYWKLKRKINFNKPLITPKKDEEDNL JADE1_BOVIN JADE1_BOVIN QKLQQLEDEFYTFVNLLDVARALRLPEEVVDFLYQYWKLKRKVNFNKPLITPKKDEEDNL B4DM93_HUMAN B4DM93_HUMAN QKLQQLEDEFYTFVNLLDVARALRLPEEVVDFLYQYWKLKRKVNFNKPLITPKKDEEDNL B4E3Q3_HUMAN B4E3Q3_HUMAN QKLQQLEDEFYTFVNLLDVARALRLPEEVVDFLYQYWKLKRKVNFNKPLITPKKDEEDNL B4E2E2_HUMAN B4E2E2_HUMAN QKLQQLEDEFYTFVNLLDVARALRLPEEVVDFLYQYWKLKRKVNFNKPLITPKKDEEDNL JADE1_HUMAN JADE1_HUMAN QKLQQLEDEFYTFVNLLDVARALRLPEEVVDFLYQYWKLKRKVNFNKPLITPKKDEEDNL A1A5F9_XENTR A1A5F9_XENTR FKLQQLEDEFHTFVDVQEISQALKIPLDMTEYIYQYWKLRRKANFNEPLITPKKDEEDNL JADE1_XENLA JADE1_XENLA LKLQQLEDDFYSFVDVHDISQALKIPLDVTEYIYQYWKLRRKANFNEPLITPKKDEEDNL MATCH :: :*::*: * :: : : : .:**::* * *..*. * :* * CONSENSUS Q?L??LE??FY??V????VA??L??????VDF?Y?YWKLKRK?N?N?PL??PK?DE???L

Q6IE91_CIOIN Q6IE91_CIOIN AEAAETNLQRRLRMFTHLRQDLER-----------------------------------V JADE3_DANRE JADE3_DANRE LQPQEDSIHTRMRMFMHLRQDLER-----------------------------------V JADE3_XENTR JADE3_XENTR VQPKEDSIHTRMRMFMHLRQDLER-----------------------------------V B1AV39_MOUSE B1AV39_MOUSE VQPKEESIHTRMRMFMHLRQDLER-----------------------------------V JADE3_MOUSE JADE3_MOUSE VQPKEESIHTRMRMFMHLRQDLER-----------------------------------V A8K5A5_HUMAN A8K5A5_HUMAN VQPKEESIHTRMRMFMHLRQDLER-----------------------------------V JADE3_HUMAN JADE3_HUMAN VQPKEESIHTRMRMFMHLRQDLER-----------------------------------V Q4RS29_TETNG Q4RS29_TETNG AQQEQDVLYRRLKLFTHLRQDLERMKLRHEVIICPPGCESPPVTIAPTRAAGFCLGPVEV Q4QQY4_XENLA Q4QQY4_XENLA AQQEQDVLYRRLKLFTHLRQDLER-----------------------------------V B5DEP9_RAT B5DEP9_RAT AQQEQDVLYRRLKLFTHLRQDLER-----------------------------------V A2AA59_MOUSE A2AA59_MOUSE AQQEQDVLYRRLKLFTHLRQDLER-----------------------------------V A2AA60_MOUSE A2AA60_MOUSE AQQEQDVLYRRLKLFTHLRQDLER-----------------------------------V JADE2_MOUSE JADE2_MOUSE AQQEQDVLYRRLKLFTHLRQDLER-----------------------------------V B5MBX1_HUMAN B5MBX1_HUMAN AQQEQDVLYRRLKLFTHLRQDLER------------------------------------ A8K9C0_HUMAN A8K9C0_HUMAN AQQEQDVLYRRLKLFTHLRQDLER-----------------------------------V A8K356_HUMAN A8K356_HUMAN AQQEQDVLYRRLKLFTHLRQDLER-----------------------------------V B3KPL2_HUMAN B3KPL2_HUMAN AQQEQDVLYRRLKLFTHLRQDLER-----------------------------------V B4DFY8_HUMAN B4DFY8_HUMAN AQQEQDVLYRRLKLFTHLRQDLER-----------------------------------V JADE2_HUMAN JADE2_HUMAN AQQEQDVLYRRLKLFTHLRQDLER-----------------------------------V Q4S6E3_TETNG Q4S6E3_TETNG ARREQEVLRCRLQLFTHLRQDLER-----------------------------------V JADE1_DANRE JADE1_DANRE ARREQEVLLRRLRLFTHLRQDLER-----------------------------------V JADE1_MOUSE JADE1_MOUSE AKREQDVLFRRLQLFTHLRQDLER-----------------------------------V JADE1_BOVIN JADE1_BOVIN AKREQDVLFRRLQLFTHLRQDLER-----------------------------------V B4DM93_HUMAN B4DM93_HUMAN AKREQDVLFRRLQLFTHLRQDLER-----------------------------------V B4E3Q3_HUMAN B4E3Q3_HUMAN AKREQDVLFRRLQLFTHLRQDLER-----------------------------------V B4E2E2_HUMAN B4E2E2_HUMAN AKREQDVLFRRLQLFTHLRQDLER-----------------------------------V JADE1_HUMAN JADE1_HUMAN AKREQDVLFRRLQLFTHLRQDLER-----------------------------------V A1A5F9_XENTR A1A5F9_XENTR AKKEQDVLIRRLQLFTHLRQDLER-----------------------------------V JADE1_XENLA JADE1_XENLA AKKEQDVLIRRLQLFTHLRQDLER-----------------------------------V MATCH . : : *:::* ******** CONSENSUS ??????????R???F?HLRQDLER???????????????????????????????????V

Q6IE91_CIOIN Q6IE91_CIOIN RNLCYMI----------------------------------------------------- JADE3_DANRE JADE3_DANRE RNLCYMVSRREKLKLSQSKAQEQIFNLHVKLVNQE------------------------- JADE3_XENTR JADE3_XENTR RNLCYMVNRREKLKLSHSKMHEEIFNLQVQLVNQE------------------------- B1AV39_MOUSE B1AV39_MOUSE RNLCYMISRREKLKLSHTKVQEQIFGLQVQLINEE------------------------- JADE3_MOUSE JADE3_MOUSE RNLCYMISRREKLKLSHTKVQEQIFGLQVQLINEE------------------------- A8K5A5_HUMAN A8K5A5_HUMAN RNLCYMISRREKLKLSHNKIQEQIFGLQVQLLNQE------------------------- JADE3_HUMAN JADE3_HUMAN RNLCYMISRREKLKLSHNKIQEQIFGLQVQLLNQE------------------------- Q4RS29_TETNG Q4RS29_TETNG RNLCYMVTRREKMKHTLCDLQEKIFHLQIQLLEEDIAGGETETNETPQLWLHGSSDGLRV Q4QQY4_XENLA Q4QQY4_XENLA RNLCYMITRREKMKQSICKIEEQIFQLQMKLIEKN------------------------- B5DEP9_RAT B5DEP9_RAT RNLCYMVTRRERTKHTICKLQEQIFHLQMKLIEQD------------------------- A2AA59_MOUSE A2AA59_MOUSE RNLCYMVTRRERTKHTICKLQEQIFHLQMKLIEQD------------------------- A2AA60_MOUSE A2AA60_MOUSE RNLCYMVTRRERTKHTICKLQEQIFHLQMKLIEQD------------------------- JADE2_MOUSE JADE2_MOUSE RNLCYMVTRRERTKHTICKLQEQIFHLQMKLIEQD------------------------- B5MBX1_HUMAN B5MBX1_HUMAN ------------------------------------------------------------ A8K9C0_HUMAN A8K9C0_HUMAN RNLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQD------------------------- A8K356_HUMAN A8K356_HUMAN RNLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQD------------------------- B3KPL2_HUMAN B3KPL2_HUMAN RNLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQD------------------------- B4DFY8_HUMAN B4DFY8_HUMAN RNLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQD------------------------- JADE2_HUMAN JADE2_HUMAN RNLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQD------------------------- Q4S6E3_TETNG Q4S6E3_TETNG RNLTYMVTRREKMKRSMWKVQEQIFQHQVHLLDHE------------------------- JADE1_DANRE JADE1_DANRE RNLTYMVSRRERIKRTLCRVQEQIFHHHVRLLEQG------------------------- JADE1_MOUSE JADE1_MOUSE RNLTYMVTRREKIKRSVCKVQEQIFTQYTKLLEQE------------------------- JADE1_BOVIN JADE1_BOVIN ------------------------------------------------------------ B4DM93_HUMAN B4DM93_HUMAN RNLTYMVTRREKIKRSVCKVQEQIFNLYTKLLEQE------------------------- B4E3Q3_HUMAN B4E3Q3_HUMAN RNLTYMVTRREKIKRSVCKVQEQIFNLYTKLLEQE------------------------- B4E2E2_HUMAN B4E2E2_HUMAN RNLTYMVTRREKIKRSVCKVQEQIFNLYTKLLEQE------------------------- JADE1_HUMAN JADE1_HUMAN RNLTYMVTRREKIKRSVCKVQEQIFNLYTKLLEQE------------------------- A1A5F9_XENTR A1A5F9_XENTR RNLTYMVTRREKMKRSVCRVQEQIFNLYAKISEQE------------------------- JADE1_XENLA JADE1_XENLA RNLTYMVTRREKMKRSVCRVQEQIFNLYTKISEQE------------------------- MATCH CONSENSUS RNL?YM??RRE??K??????QEQIF?????L?????????????????????????????

Q6IE91_CIOIN Q6IE91_CIOIN -------------------------------G---------------------------- JADE3_DANRE JADE3_DANRE --------LSA--------------------GLPVSSS---IENLLFH--PPPRITLKLK JADE3_XENTR JADE3_XENTR --------VAA--------------------GQPLSNA---LENTLFY--PPPRITLKLK B1AV39_MOUSE B1AV39_MOUSE --------ITE--------------------GLSLTNA---LENSLFY--PPPRITLKLK JADE3_MOUSE JADE3_MOUSE --------ITE--------------------GLSLTNA---LENSLFY--PPPRITLKLK A8K5A5_HUMAN A8K5A5_HUMAN --------IDA--------------------GLPLTNA---LENSLFY--PPPRITLKLK JADE3_HUMAN JADE3_HUMAN --------IDA--------------------GLPLTNA---LENSLFY--PPPRITLKLK Q4RS29_TETNG Q4RS29_TETNG CERKEEKVRVKDEKGQKEKSQRGKRKQNGVKERGKERRKSSPQKKKEKLSENGSLLKELG Q4QQY4_XENLA Q4QQY4_XENLA --------LQN--------------------G---------------------------- B5DEP9_RAT B5DEP9_RAT --------LCR--------------------G---------------------------- A2AA59_MOUSE A2AA59_MOUSE --------LCREPSGRRSKGKKNDSKRKGREG-PKGSSPEKKEKVKAG--PESVLGQLAG A2AA60_MOUSE A2AA60_MOUSE --------LCREPSGRRSKGKKNDSKRKGREG-PKGSSPEKKEKVKAG--PESVLGQ-LG JADE2_MOUSE JADE2_MOUSE --------LCREPSGRRSKGKKNDSKRKGREG-PKGSSPEKKEKVKAG--PESVLGQ-LG B5MBX1_HUMAN B5MBX1_HUMAN ------------------------------------------------------------ A8K9C0_HUMAN A8K9C0_HUMAN --------LCR-----------------------------------------------AG A8K356_HUMAN A8K356_HUMAN --------LCR------------------------------------------------G B3KPL2_HUMAN B3KPL2_HUMAN --------LCRERSGRRAKGKKSDSKRKGCEG-SKGST-EKKEKVKAG--PDSVLGQLAG B4DFY8_HUMAN B4DFY8_HUMAN --------LCRERSGRRAKGKKSDSKRKGCEG-SKGST-EKKEKVKAG--PDSVLGQLAG JADE2_HUMAN JADE2_HUMAN --------LCR------------------------------------------------G Q4S6E3_TETNG Q4S6E3_TETNG --------LLT--------------------GDPSAKDLENLVFLGWFSSPDPRSRSSCA JADE1_DANRE JADE1_DANRE --------RVT--------------------GVSSTRRLEEAMFYFRT--TPPVPASPQP JADE1_MOUSE JADE1_MOUSE --------KVS--------------------GVPSSCS-SALENMLFF--NSPSVGPNAP JADE1_BOVIN JADE1_BOVIN ------------------------------------------------------------ B4DM93_HUMAN B4DM93_HUMAN --------RVS--------------------GVPSSCSSSSLENMLLF--NSPSVGPDAP B4E3Q3_HUMAN B4E3Q3_HUMAN --------RVS--------------------GVPSSCSSSSLENMLLF--NSPSVGPDAP B4E2E2_HUMAN B4E2E2_HUMAN --------RVS--------------------GVPSSCSSSSLENMLLF--NSPSVGPDAP JADE1_HUMAN JADE1_HUMAN --------RVS--------------------GVPSSCSSSSLENMLLF--NSPSVGPDAP A1A5F9_XENTR A1A5F9_XENTR --------KNL--------------------GFP-------LESVLLF--NTQPSDPDAP JADE1_XENLA JADE1_XENLA --------KDL--------------------GFP-------LENGLLF--NTQPSNPDAP MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q6IE91_CIOIN Q6IE91_CIOIN ------------------------------------------------------------ JADE3_DANRE JADE3_DANRE MPK-VQLGNGKSSSKSGNGPLCPDNSC--NLYDTSEG-----GIGQGKPQLHLGRQRIEE JADE3_XENTR JADE3_XENTR MPKPRTRDCRISSVKAGTMSSPDNQNS----SATYHGMGGEVHRQSSEHTKLYSTYASEQ B1AV39_MOUSE B1AV39_MOUSE MPKSTSEDCKDSSTETEHQLSSPGSSSPGHSKRSPQM----PEEPLDMNVKIYPRYPLES JADE3_MOUSE JADE3_MOUSE MPKSTSEDCKDSSTETEHQLSSPGSSSPGHSKRSPQM----PEEPLDMNVKIYPRYPLES A8K5A5_HUMAN A8K5A5_HUMAN MPKSTPEDHRNSSTETDQQPHSPDSSSSVHSIRNMQV----PQESLEMRTKSYPRYPLES JADE3_HUMAN JADE3_HUMAN MPKSTPEDHRNSSTETDQQPHSPDSSSSVHSIRNMQV----PQESLEMRTKSYPRYPLES Q4RS29_TETNG Q4RS29_TETNG LSKSFPLDKSLFDSWLAQSVQITADDM---LSQWT------LGAQHRDKSGSLLSDQLLQ Q4QQY4_XENLA Q4QQY4_XENLA ------------------------------------------------------------ B5DEP9_RAT B5DEP9_RAT ----------------GHSAPCWEEPS--------------------------------- A2AA59_MOUSE A2AA59_MOUSE ------WHSRFRS----------------QQRTWP------------------------- A2AA60_MOUSE A2AA60_MOUSE LSTSFPIDGTFFNSWLAQSVQITAEDM--AMSEWSLN----SGHREDPAPGLLS-EELLQ JADE2_MOUSE JADE2_MOUSE LSTSFPIDGTFFNSWLAQSVQITAEDM--AMSEWSLN----SGHREDPAPGLLS-EELLQ B5MBX1_HUMAN B5MBX1_HUMAN -------------SGLG------------------------------------------- A8K9C0_HUMAN A8K9C0_HUMAN LSTSFPIDGTFFNSWLAQSVQITAENM--AMSEWPLN----NGHREDPAPGLLS-EELLQ A8K356_HUMAN A8K356_HUMAN LSTSFPIDGTFFNSWLAQSVQITAENM--AMSEWPLN----NGHREDPAPGLLS-EELLQ B3KPL2_HUMAN B3KPL2_HUMAN LSTSFPIDGTFFNSWLAQSVQITAENM--AMSEWPLN----NGHREDPAPGLLS-EELLQ B4DFY8_HUMAN B4DFY8_HUMAN LSTSFPIDGTFFNSWLAQSVQITAENM--AMSEWPLN----NGHREDPAPGLLS-EELLQ JADE2_HUMAN JADE2_HUMAN LSTSFPIDGTFFNSWLAQSVQITAENM--AMSEWPLN----NGHREDPAPGLLS-EELLQ Q4S6E3_TETNG Q4S6E3_TETNG PSALKPKQGPLKVEKRKLSARKGLDSPEAPRRDGP------SRDGRGAQNGGSGSESESK JADE1_DANRE JADE1_DANRE LKGHCGQNSTLSSSEKGSNSYRSSKHIEADKPAKMLM------------DGVPSSGDSVR JADE1_MOUSE JADE1_MOUSE KIEDLKWHSAFFRKQMGTSLVHPLKKS--HKRDAVQNSSGTEGKTSHKQPGLCGRREGLE JADE1_BOVIN JADE1_BOVIN ------------------------------------------------------------ B4DM93_HUMAN B4DM93_HUMAN KIEDLKWHSAFFRKQMGTSLVHSLKKP--HKRDPLQNSPGSEGKTLLKQPDLCGRREGMV B4E3Q3_HUMAN B4E3Q3_HUMAN KIEDLKWHSAFFRKQMGTSLVHSLKKP--HKRDPLQNSPGSEGKTLLKQPDLCGRREGVV B4E2E2_HUMAN B4E2E2_HUMAN KIEDLKWHSAFFRKQMGTSLVHSLKKP--HKRDPLQNSPGSEGKTLLKQPDLCGRREGMV JADE1_HUMAN JADE1_HUMAN KIEDLKWHSAFFRKQMGTSLVHSLKKP--HKRDPLQNSPGSEGKTLLKQPDLCGRREGMV A1A5F9_XENTR A1A5F9_XENTR KIEDLKWHSAFFRKQLGSTLGCSMKDS--HKKSRVRI----MGKSLDTEILLPERKKEGQ JADE1_XENLA JADE1_XENLA KIEDLKWHSAFFRKRLGSSLRCSMKDS--HKKSRERI----IGKSLDTEILLTDRKKEGQ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q6IE91_CIOIN Q6IE91_CIOIN ------------------------------------------------------------ JADE3_DANRE JADE3_DANRE RINGILPASIYI------------RRDGGTPPLAVKQ--SGKPL---------------- JADE3_XENTR JADE3_XENTR RNNGLLGGITRFHKEFQGTGCKPSSRFRSSGKPMSLQAVIHGQS---------------- B1AV39_MOUSE B1AV39_MOUSE KSNCLQTSRSHSR--CETKSSSPTPRAPSAEFYHGQS--LGKPL---------------- JADE3_MOUSE JADE3_MOUSE KSNCLQTSRSHSR--CETKSSSPTPRAPSAEFYHGQS--LGKPL---------------- A8K5A5_HUMAN A8K5A5_HUMAN KNNRLLASLSHSR--SEAKESSPAWRTPSSECYHGQS--LGKPL---------------- JADE3_HUMAN JADE3_HUMAN KNNRLLASLSHSR--SEAKESSPAWRTPSSECYHGQS--LGKPL---------------- Q4RS29_TETNG Q4RS29_TETNG GEESLLNLMMENSMQSTWKTPHLGRKQRGSSKSRPRGPSQSPSPGLPPPLLSAAATSAAS Q4QQY4_XENLA Q4QQY4_XENLA ---------------SQRRPFESCKESEEKKK---KK----------------------- B5DEP9_RAT B5DEP9_RAT -----------------------GRRSKGKKNDAKKK----------------------- A2AA59_MOUSE A2AA59_MOUSE ------------------------------------------------------------ A2AA60_MOUSE A2AA60_MOUSE DEETLLSFMRD----PSLRPGDPARKARGRTRLPAKK--KPSPL---------------- JADE2_MOUSE JADE2_MOUSE DEETLLSFMRD----PSLRPGDPARKARGRTRLPAKK--KPSPL---------------- B5MBX1_HUMAN B5MBX1_HUMAN ---------------GEQRARRVTRRGRAARAPRAAL--RRKRK---------------- A8K9C0_HUMAN A8K9C0_HUMAN DEETLLSFMRD----PSLRPGDPARKARGRTRLPAKK--KPPPP---------------- A8K356_HUMAN A8K356_HUMAN DEETLLSFMRD----PSLRPGDPARKARGRTRLPAKK--KPPPP---------------- B3KPL2_HUMAN B3KPL2_HUMAN DEETLLSFMRD----PSLRPGDPARKARGRTRLPAKK--KPPPP---------------- B4DFY8_HUMAN B4DFY8_HUMAN DEETLLSFMRD----PSLRPGDPARKARGRTRLPAKK----------------------- JADE2_HUMAN JADE2_HUMAN DEETLLSFMRD----PSLRPGDPARKARGRTRLPAKK--KPPPP---------------- Q4S6E3_TETNG Q4S6E3_TETNG SREEIPS--------PELREPEASQEEAKLCRLESRKAPRKEAP---------------- JADE1_DANRE JADE1_DANRE SETVMSASSRRSE--GRTRSGESHRKEEESERPLEDR--RRKSK---------------- JADE1_MOUSE JADE1_MOUSE VSESLLSLEKTF---AEARLLSSAQQKNGVVTPDHGK--RRDNR---------------- JADE1_BOVIN JADE1_BOVIN ------------------------------------------------------------ B4DM93_HUMAN B4DM93_HUMAN VPESFLGLEKTF---AEARLI-SAQQKNGVVMPDHGK--RRDNR---------------- B4E3Q3_HUMAN B4E3Q3_HUMAN VPESFLGLEKTF---AEARLI-SAQQKNGVVMPDHGK--RRDNR---------------- B4E2E2_HUMAN B4E2E2_HUMAN VPESFLGLEKTF---AEARLI-SAQQKNGVVMPDHGK--RRDNR---------------- JADE1_HUMAN JADE1_HUMAN VPESFLGLEKTF---AEARLI-SAQQKNGVVMPDHGK--RRDNR---------------- A1A5F9_XENTR A1A5F9_XENTR TSDVSFSFEKTV---AKIRPV---QQKNGASMPEHRK--RRDSR---------------- JADE1_XENLA JADE1_XENLA TSDVSFPLEKTV---AKIKPV---QQKNGGSFPEHRK--RRDSR---------------- MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q6IE91_CIOIN Q6IE91_CIOIN ------------------------------------------------------------ JADE3_DANRE JADE3_DANRE ---------------ALHAALHGQSSNGKTKNEAE--KS--RQIKSNGILDK----PILQ JADE3_XENTR JADE3_XENTR ---------------S-----NGSGKVQHEHVSLA--RANGVLSSGDRTQRDSSSQTSPG B1AV39_MOUSE B1AV39_MOUSE ---------------ALQAALHGQVSIGNGKNQPN-----SRVSSSNGLEGNWSGNITQK JADE3_MOUSE JADE3_MOUSE ---------------ALQAALHGQVSIGNGKNQPN-----SRVSSSNGLEGNWSGNITQK A8K5A5_HUMAN A8K5A5_HUMAN ---------------VLQAALHGQSSIGNGKSQPN-----SKFAKSNGLEGSWSGNVTQK JADE3_HUMAN JADE3_HUMAN ---------------VLQAALHGQSSIGNGKSQPN--SKF---AKSNGLEGSWSGNVTQK Q4RS29_TETNG Q4RS29_TETNG RPSSTKNLWVNVQEKFSHLGQRGERSRSSLKALHH--HFHQHQSRNSDLRRDPPPQPPIS Q4QQY4_XENLA Q4QQY4_XENLA ------------------------------------------------------------ B5DEP9_RAT B5DEP9_RAT ------------------------------------------------------------ A2AA59_MOUSE A2AA59_MOUSE ------------------------------------------------------------ A2AA60_MOUSE A2AA60_MOUSE ---------------Q-----DGPSARTTPDKQPK--KAWAQDGKGTQGPPM---RKPPR JADE2_MOUSE JADE2_MOUSE ---------------Q-----DGPSARTTPDKQPK--KAWAQDGKGTQGPPM---RKPPR B5MBX1_HUMAN B5MBX1_HUMAN ------------------------------------------------------------ A8K9C0_HUMAN A8K9C0_HUMAN ---------------PPQ---DGPGSRTTPDKAPK--KTWGQDAGSGKGGQGPPTRKPPR A8K356_HUMAN A8K356_HUMAN ---------------PPQ---DGPGSRTTPDKAPK--KTWGQDAGSGKGGQGPPTRKPPR B3KPL2_HUMAN B3KPL2_HUMAN ---------------PPQ---DGPGSRTTPDKAPK--KTWGQDAGSGKGGQGPPTRKPPR B4DFY8_HUMAN B4DFY8_HUMAN --------------------------------------------------------KPPR JADE2_HUMAN JADE2_HUMAN ---------------PPQ---DGPGSRTTPDKAPK--KTWGQDAGSGKGGQGPPTRKPPR Q4S6E3_TETNG Q4S6E3_TETNG ----------------------GPTQEDLVGQEPEEDQEERRKKKRSDMMDRFRFKHLEK JADE1_DANRE JADE1_DANRE ---------------L-------------WDQVSI--KDKLRHAKSMED-------TLSS JADE1_MOUSE JADE1_MOUSE ---------------F-----HCDLVKGDLKDKSF--KQSHKPLRSTDTSQR----HLDN JADE1_BOVIN JADE1_BOVIN ------------------------------------------------------------ B4DM93_HUMAN B4DM93_HUMAN ---------------F-----HCDLIKGDLKDKSF--KQSHKPLRSTDVSQR----HLDN B4E3Q3_HUMAN B4E3Q3_HUMAN ---------------F-----HCDLIKGDLKDKSF--KQSHKPLRSTDVSQR----HLDN B4E2E2_HUMAN B4E2E2_HUMAN ---------------F-----HCDLIKGDLKDKSF--KQSHKPLRSTDVSQR----HLDN JADE1_HUMAN JADE1_HUMAN ---------------F-----HCDLIKGDLKDKSF--KQSHKPLRSTDVSQR----HLDN A1A5F9_XENTR A1A5F9_XENTR ---------------A-----QGDPAKFSLKEKPP--RQQHRPAKPAEPPER----PAEN JADE1_XENLA JADE1_XENLA ---------------------TQGDTKFDSKEKPL--RQQHRPAKHTEPPER----PAEK MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q6IE91_CIOIN Q6IE91_CIOIN ------------------------------------------------------------ JADE3_DANRE JADE3_DANRE RDTSCLA-------------------A----------SEKDPRSEISGKSQSSGFHKTSL JADE3_XENTR JADE3_XENTR QNSEIIC---------HIAGQSTFRKA----------NMEHFSRSFKEATNNLVRTTEDL B1AV39_MOUSE B1AV39_MOUSE VNSSEVCYDQESMLSSHLPSPGNIRKS----------SMEHFSRSFKEATNTWVKPTEDL JADE3_MOUSE JADE3_MOUSE VNSSEVCYDQESMLSSHLPSPGNIRKS----------SMEHFSRSFKEATNTWVKPTEDL A8K5A5_HUMAN A8K5A5_HUMAN DSSSEMFCDQEPVFSPHLVSQGSFRKS----------TVEHFSRSFKETTNRWVKNTEDL JADE3_HUMAN JADE3_HUMAN DSSSEMFCDQEPVFSPHLVSQGSFRKS----------TVEHFSRSFKETTNRWVKNTEDL Q4RS29_TETNG Q4RS29_TETNG KMDSCHISEDHDRWESVHSGGGVAAGTRSGFSTSSSLAPASSPGLDTGTLLQSSVPRLRV Q4QQY4_XENLA Q4QQY4_XENLA ------------------------------------------------------------ B5DEP9_RAT B5DEP9_RAT ------------------------------------------------------------ A2AA59_MOUSE A2AA59_MOUSE ------------------------------------------------------------ A2AA60_MOUSE A2AA60_MOUSE RTSSHLP--------SSPAAGDCPVPA----------TLESPPPLASEILDKTAPMASDL JADE2_MOUSE JADE2_MOUSE RTSSHLP--------SSPAAGDCPVPA----------TLESPPPLASEILDKTAPMASDL B5MBX1_HUMAN B5MBX1_HUMAN ------------------------------------------------------------ A8K9C0_HUMAN A8K9C0_HUMAN RTSSHLP--------SSPAAGDCPILA----------TPESPPPLAPETPDEAASVAADS A8K356_HUMAN A8K356_HUMAN RTSSHLP--------SSPAAGDCPILA----------TPESPPPLAPETPDEAASVAADS B3KPL2_HUMAN B3KPL2_HUMAN RTSSHLP--------SSPAAGDCPILA----------TPESPPPLAPETPDEAASVAADS B4DFY8_HUMAN B4DFY8_HUMAN RTSSHLP--------SSPAAGDCPILA----------TPESPPPLAPETPDEAASVAADS JADE2_HUMAN JADE2_HUMAN RTSSHLP--------SSPAAGDCPILA----------TPESPPPLAPETPDEAASVAADS Q4S6E3_TETNG Q4S6E3_TETNG SVSIRLV--------DIRNSDIGGAAR----------GPFRSPVLLSDVAVGNRANGWLK JADE1_DANRE JADE1_DANRE ETELDTM--------DDRLLLSHTNAN----------SVATAPNMYSGSPRKTNASHQGK JADE1_MOUSE JADE1_MOUSE TRAATSP------------GVGQSAPG----------TRKEIVPKCNGSLVKVP------ JADE1_BOVIN JADE1_BOVIN ------------------------------------------------------------ B4DM93_HUMAN B4DM93_HUMAN TRAAAI------------------------------------------------------ B4E3Q3_HUMAN B4E3Q3_HUMAN TRAATSP------------GVGQSAPG----------TRKEIVPKCNGSLIKVNYNQTAV B4E2E2_HUMAN B4E2E2_HUMAN TRAATSP------------GVGQSAPG----------TRKEIVPKCNGSLIKVNYNQTAV JADE1_HUMAN JADE1_HUMAN TRAATSP------------GVGQSAPG----------TRKEIVPKCNGSLIKVNYNQTAV A1A5F9_XENTR A1A5F9_XENTR KRVLSQC--------GSKTATTSANKK----------QCSSSLPRYSGSLIKLHCKQSSV JADE1_XENLA JADE1_XENLA KRALSQC--------GGKSATASSNKK----------QCSSSLPRYSGSLIKIHCNRPSV MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q6IE91_CIOIN Q6IE91_CIOIN ------------------------------------------------------------ JADE3_DANRE JADE3_DANRE EHFSRSLKEATVSLVRTEDLRTFEKNSRK-----SSGFSKP------------------- JADE3_XENTR JADE3_XENTR RSSEKPQRRQSVKERLWS--KQPADTQTS------------------------------- B1AV39_MOUSE B1AV39_MOUSE QYCVKPTKNVSSKEQLWGRQLLRRPTGRA------------------------------- JADE3_MOUSE JADE3_MOUSE QYCVKPTKNVSSKEQLWGRQLLRRPTGRA------------------------------- A8K5A5_HUMAN A8K5A5_HUMAN QCYVKPTKNMSPKEQFWGRQVLRRSAGRA------------------------------- JADE3_HUMAN JADE3_HUMAN QCYVKPTKNMSPKEQFWGRQVLRRSAGRA------------------------------- Q4RS29_TETNG Q4RS29_TETNG SRQAKSRGRSFGCVEDLEAVRLPLPEKDRLEAAETDGYFSDGEQSDVDTRSGKRKLRLPP Q4QQY4_XENLA Q4QQY4_XENLA ------------------------------------------------------------ B5DEP9_RAT B5DEP9_RAT -----------------------KKKKKK------------------------------- A2AA59_MOUSE A2AA59_MOUSE ------------------------------------------------------------ A2AA60_MOUSE A2AA60_MOUSE NVQV---PGPTVSPKPLGRLRPPREMKVS---RKSPGARSDAGTG------------LP- JADE2_MOUSE JADE2_MOUSE NVQV---PGPTVSPKPLGRLRPPREMKVS---RKSPGARSDAGTG------------LP- B5MBX1_HUMAN B5MBX1_HUMAN ------------------------------------------------------------ A8K9C0_HUMAN A8K9C0_HUMAN DVQV---PGPAASPKPLGRLRPPRESKVT---RRLPGARPDAGMG------------PP- A8K356_HUMAN A8K356_HUMAN DVQV---PGPAASPKPLGRLRPPRESKVT---RRLPGARPDAGMG------------PP- B3KPL2_HUMAN B3KPL2_HUMAN DVQV---PGPAASPKPLGRLRPPRESKVT---RRLPGARPDAGMG------------PP- B4DFY8_HUMAN B4DFY8_HUMAN DVQV---PGPAASPKPLGRLRPPRESKVT---RRLPGARPDAGMG------------PP- JADE2_HUMAN JADE2_HUMAN DVQV---PGPAASPKPLGRLRPPRESKVT---RRLPGARPDAGMG------------PP- Q4S6E3_TETNG Q4S6E3_TETNG KPAAGGRAAAAGHLRSWGKFRIPKRNEKT------AAEEPPLLPN--------------- JADE1_DANRE JADE1_DANRE LVPN---GTSGRHLKNWGSFRIPKRSERTSAGRQTERQEADNTAD------------QNS JADE1_MOUSE JADE1_MOUSE -------ITPASPVKSWGGFRIPKKGERQ---QQGEAHDGACHQH------------SDC JADE1_BOVIN JADE1_BOVIN ------------------------------------------------------------ B4DM93_HUMAN B4DM93_HUMAN ----------------W-RFRVIWQG---------------------------------- B4E3Q3_HUMAN B4E3Q3_HUMAN KVP----TTPASPVKNWGGFRIPKKGERQ---QQGEAHDGACHQH------------SDY B4E2E2_HUMAN B4E2E2_HUMAN KVP----TTPASPVKNWGGFRIPKKGERQ---QQGEAHDGACHQH------------SDY JADE1_HUMAN JADE1_HUMAN KVP----TTPASPVKNWGGFRIPKKGERQ---QQGEAHDGACHQH------------SDY A1A5F9_XENTR A1A5F9_XENTR KV-------PTSPVKNWGGFRIPKKGERQ----QQPGNMETCQPN------------LNC JADE1_XENLA JADE1_XENLA KV-------PTSPIKNWGGFRIPKKGEKV-----QPGSMETCQPN------------LNC MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q6IE91_CIOIN Q6IE91_CIOIN ------------------------------------------------------------ JADE3_DANRE JADE3_DANRE --------LSTERPQGGGRASQESDGYCPDAE-------------------------LSD JADE3_XENTR JADE3_XENTR -----------------GTPYQDNDGYCPDLE-------------------------LSD B1AV39_MOUSE B1AV39_MOUSE -------------------SYQETDGYCPDLE-------------------------PSD JADE3_MOUSE JADE3_MOUSE -------------------SYQETDGYCPDLE-------------------------PSD A8K5A5_HUMAN A8K5A5_HUMAN -------------------PYQENDGYCPDLE-------------------------LSD JADE3_HUMAN JADE3_HUMAN -------------------PYQENDGYCPDLE-------------------------LSD Q4RS29_TETNG Q4RS29_TETNG LHSRERGSAEKERASVLKHRDSGHALKSPCGGSKHTPLWSRFIAHLLSSWDDYECSCLPG Q4QQY4_XENLA Q4QQY4_XENLA ------------------------------------------------------------ B5DEP9_RAT B5DEP9_RAT ------------------------------------------------------------ A2AA59_MOUSE A2AA59_MOUSE ------------------------------------------------------------ A2AA60_MOUSE A2AA60_MOUSE -------SAVAERPKVSLHFDTEADGYFSDEE-------------------------MSD JADE2_MOUSE JADE2_MOUSE -------SAVAERPKVSLHFDTEADGYFSDEE-------------------------MSD B5MBX1_HUMAN B5MBX1_HUMAN ------------------------------------------------------------ A8K9C0_HUMAN A8K9C0_HUMAN -------SAVAERPKVSLHFDTETDGYFSDGE-------------------------MSD A8K356_HUMAN A8K356_HUMAN -------SAVAERPKVSLHFDTETDGYFSDGE-------------------------MSD B3KPL2_HUMAN B3KPL2_HUMAN -------SAVAERPKVSLHFDTETDGYFSDGE-------------------------MSD B4DFY8_HUMAN B4DFY8_HUMAN -------SAVAERPKVSLHFDTETDGYFSDGE-------------------------MSD JADE2_HUMAN JADE2_HUMAN -------SAVAERPKVSLHFDTETDGYFSDGE-------------------------MSD Q4S6E3_TETNG Q4S6E3_TETNG ---------ASSQPRTRLRTGAENAGYSPT---------------------------AGE JADE1_DANRE JADE1_DANRE SLKTFSTSPSSPQIRTRLRTGSENRRHLEESD-------------------------LGQ JADE1_MOUSE JADE1_MOUSE SHLGVSRAPAKERAKSRLRADSENDGYAPDGE-------------------------MSD JADE1_BOVIN JADE1_BOVIN ---------------------------------------------------------MTD B4DM93_HUMAN B4DM93_HUMAN --------PAA------------------------------------------------- B4E3Q3_HUMAN B4E3Q3_HUMAN PYLGLDRVPAKERAKSKLKSDNENDGYVPDVE-------------------------MSD B4E2E2_HUMAN B4E2E2_HUMAN PYLGLGRVPAKERAKSKLKSDNENDGYVPDVE-------------------------MSD JADE1_HUMAN JADE1_HUMAN PYLGLGRVPAKERAKSKLKSDNENDGYVPDVE-------------------------MSD A1A5F9_XENTR A1A5F9_XENTR QF-------------------------------------------------------LGQ JADE1_XENLA JADE1_XENLA QFLGQ--VSKKGRTKEKVKLDNDNDGYTPDAE-------------------------MSD MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q6IE91_CIOIN Q6IE91_CIOIN ------------------------------------------------------------ JADE3_DANRE JADE3_DANRE SEPEAKGKCRQ----GGRTQ----------NQRGDYVKSASRAKHSYGSRTSVQR----- JADE3_XENTR JADE3_XENTR SEAESDENKDHMLLRRNSRE------SPNRDSCRNSRIRGKRKMTSHSSVQR-------- B1AV39_MOUSE B1AV39_MOUSE SEAEGEGSKETPRVKRESSDRENPSH----DSARECHGKTKTHPHSHSSMQR-------- JADE3_MOUSE JADE3_MOUSE SEAEGEGSKETPRVKRESSDRENPSH----DSARECHGKTKTHPHSHSSMQR-------- A8K5A5_HUMAN A8K5A5_HUMAN SEAESDGNKEKVRVRKDSSDRENPPH----DSRRDCHGKSKTHPLSHSSMQR-------- JADE3_HUMAN JADE3_HUMAN SEAESDGNKEKVRVRKDSSDRENPPH----DSRRDCHGKSKTHPLSHSSMQR-------- Q4RS29_TETNG Q4RS29_TETNG VRLKPSTGPESPPLASHTRTSSALFALMRQIGSPPGIGRTRPWRYRPGSGDKHFWALLFL Q4QQY4_XENLA Q4QQY4_XENLA ------------------------------------------------------------ B5DEP9_RAT B5DEP9_RAT ------------------------------------------------------------ A2AA59_MOUSE A2AA59_MOUSE ------------------------------------------------------------ A2AA60_MOUSE A2AA60_MOUSE SEVEAEDSGVQ----RASRE----------AG--------AEEVVRMGVLAS-------- JADE2_MOUSE JADE2_MOUSE SEVEAEDSGVQ----RASRE----------AG--------AEEVVRMGVLAS-------- B5MBX1_HUMAN B5MBX1_HUMAN ------------------------------------------------------------ A8K9C0_HUMAN A8K9C0_HUMAN SDVEAEDGGVQ----RGPRE----------AG--------AEEVVRMGVLAS-------- A8K356_HUMAN A8K356_HUMAN SDVEAEDGGVQ----RGPRE----------AG--------AEEVVRMGVLAS-------- B3KPL2_HUMAN B3KPL2_HUMAN SDVEAEDGGVQ----RGPRE----------AG--------AEEVVRMGVLAS-------- B4DFY8_HUMAN B4DFY8_HUMAN SDVEAEDGGVQ----RGPRE----------AG--------AEEVVRMGVLAS-------- JADE2_HUMAN JADE2_HUMAN SDVEAEDGGVQ----RGPRE----------AG--------AEEVVRMGVLAS-------- Q4S6E3_TETNG Q4S6E3_TETNG GEVEPCLKRCHSHQLRGASA----------LGRRY-----GSDIIRRGVLAS-------- JADE1_DANRE JADE1_DANRE SEQGKRCHT-Q----RLPSP----------MTRRY-----GSDVIQRGVLAS-------- JADE1_MOUSE JADE1_MOUSE SESEASEKKCI----HASST----------ISR-------RTDIIRRSILAS-------- JADE1_BOVIN JADE1_BOVIN TDTL-------------------------------------------------------- B4DM93_HUMAN B4DM93_HUMAN ------------------------------------------------------------ B4E3Q3_HUMAN B4E3Q3_HUMAN SESEASEKKCI----HTSST----------ISR-------RTDIIRRSILAS-------- B4E2E2_HUMAN B4E2E2_HUMAN SESEASEKKCI----HTSST----------ISR-------RTDIIRRSILAS-------- JADE1_HUMAN JADE1_HUMAN SESEASEKKCI----HTSST----------ISR-------RTDIIRRSILAS-------- A1A5F9_XENTR A1A5F9_XENTR VSKKRKDKG-------------------------------ETQAVQ-------------- JADE1_XENLA JADE1_XENLA SESEPTDKCRLQRLTSSSS-----------LSRGY-----ETDFIRRSILAS-------- MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q6IE91_CIOIN Q6IE91_CIOIN - JADE3_DANRE JADE3_DANRE - JADE3_XENTR JADE3_XENTR - B1AV39_MOUSE B1AV39_MOUSE - JADE3_MOUSE JADE3_MOUSE - A8K5A5_HUMAN A8K5A5_HUMAN - JADE3_HUMAN JADE3_HUMAN - Q4RS29_TETNG Q4RS29_TETNG L Q4QQY4_XENLA Q4QQY4_XENLA - B5DEP9_RAT B5DEP9_RAT - A2AA59_MOUSE A2AA59_MOUSE - A2AA60_MOUSE A2AA60_MOUSE - JADE2_MOUSE JADE2_MOUSE - B5MBX1_HUMAN B5MBX1_HUMAN - A8K9C0_HUMAN A8K9C0_HUMAN - A8K356_HUMAN A8K356_HUMAN - B3KPL2_HUMAN B3KPL2_HUMAN - B4DFY8_HUMAN B4DFY8_HUMAN - JADE2_HUMAN JADE2_HUMAN - Q4S6E3_TETNG Q4S6E3_TETNG - JADE1_DANRE JADE1_DANRE - JADE1_MOUSE JADE1_MOUSE - JADE1_BOVIN JADE1_BOVIN - B4DM93_HUMAN B4DM93_HUMAN - B4E3Q3_HUMAN B4E3Q3_HUMAN - B4E2E2_HUMAN B4E2E2_HUMAN - JADE1_HUMAN JADE1_HUMAN - A1A5F9_XENTR A1A5F9_XENTR - JADE1_XENLA JADE1_XENLA - MATCH CONSENSUS ?


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