Alignment of the gene Family HBG053807 of HOVERGEN

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Threshold: 50% 80% 100%
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Isoforms are ON
WD42B_HUMAN WD42B_HUMAN ------------------------------------------------------------ B2RXH9_HUMAN B2RXH9_HUMAN ------------------------------------------------------------ WD42C_HUMAN WD42C_HUMAN ------------------------------------------------------------ Q5RAK2_PONAB Q5RAK2_PONAB ------------------------------------------------------------ Q4R6S0_MACFA Q4R6S0_MACFA ------------------------------------------------------------ WD42A_PONAB WD42A_PONAB ------------------------------------------------------------ B7Z2P6_HUMAN B7Z2P6_HUMAN SEEELTKAMEGLGMDEGDGEGNILPIMQSIMQNLLSKDVLYPSLKEITEKYPEWLQSHRE B7Z8C9_HUMAN B7Z8C9_HUMAN ------------------------------------------------------------ WD42A_HUMAN WD42A_HUMAN ------------------------------------------------------------ WD42A_MOUSE WD42A_MOUSE ------------------------------------------------------------ WD42A_RAT WD42A_RAT ------------------------------------------------------------ WD42A_XENLA WD42A_XENLA ------------------------------------------------------------ WD42A_XENTR WD42A_XENTR ------------------------------------------------------------ Q4RWS8_TETNG Q4RWS8_TETNG ------------------------------------------------------------ Q7T134_DANRE Q7T134_DANRE ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

WD42B_HUMAN WD42B_HUMAN ------------------------------------------------------------ B2RXH9_HUMAN B2RXH9_HUMAN ------------------------------------------------------------ WD42C_HUMAN WD42C_HUMAN ------------------------------------------------------------ Q5RAK2_PONAB Q5RAK2_PONAB ------------------------------------------------------------ Q4R6S0_MACFA Q4R6S0_MACFA ------------------------------------------------------------ WD42A_PONAB WD42A_PONAB ------------------------------------------------------------ B7Z2P6_HUMAN B7Z2P6_HUMAN SLPPEQFEKYQEQHSVMCKICEQFEAETPTDSETTQKARFEMVLDLMQQLQDLGHPPKEL B7Z8C9_HUMAN B7Z8C9_HUMAN ------------------------------------------------------------ WD42A_HUMAN WD42A_HUMAN ------------------------------------------------------------ WD42A_MOUSE WD42A_MOUSE ------------------------------------------------------------ WD42A_RAT WD42A_RAT ------------------------------------------------------------ WD42A_XENLA WD42A_XENLA ------------------------------------------------------------ WD42A_XENTR WD42A_XENTR ------------------------------------------------------------ Q4RWS8_TETNG Q4RWS8_TETNG ------------------------------------------------------------ Q7T134_DANRE Q7T134_DANRE ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

WD42B_HUMAN WD42B_HUMAN ---------------------------------MSHQEGSTGGLPDLVTESLFSS-PEEQ B2RXH9_HUMAN B2RXH9_HUMAN ---------------------------------MSHQEGSTDGLPDLGTESLFSS-PEEQ WD42C_HUMAN WD42C_HUMAN ---------------------------------MSHQEGSTDGLPDLGTESLFSS-PEEQ Q5RAK2_PONAB Q5RAK2_PONAB -----------------------------------------------------------M Q4R6S0_MACFA Q4R6S0_MACFA ---------------------------------MSSKGSSTDGRTDLANGSLSSS-PEEM WD42A_PONAB WD42A_PONAB ---------------------------------MSSKGSSTDGRTDLANGSLSSS-PEEM B7Z2P6_HUMAN B7Z2P6_HUMAN AGEMLTWLFFCGSQWVYGPWLTYVGWLQQTSFKMSSKGSSTDGRTDLANGSLSSS-PEEM B7Z8C9_HUMAN B7Z8C9_HUMAN ---------------------------------MSSKGSSTDGRTDLANGSLSSS-PEEM WD42A_HUMAN WD42A_HUMAN ---------------------------------MSSKGSSTDGRTDLANGSLSSS-PEEM WD42A_MOUSE WD42A_MOUSE --------------------------------MSNKRPNTTDGRTDLANGSLSSS-PEEM WD42A_RAT WD42A_RAT ---------------------------------MSSKRPSTDGRRDLANGSLSSS-PEEM WD42A_XENLA WD42A_XENLA ---------------------------------MSFSGEMSNGKTDVTNGGFSSS-PEDM WD42A_XENTR WD42A_XENTR ---------------------------------MSFSGEMANGKTDVANSGFSSS-PEDM Q4RWS8_TETNG Q4RWS8_TETNG ---------------------------------HST------------------------ Q7T134_DANRE Q7T134_DANRE ---------------------------------MSDTG----GKSSIPNGGSDDPEPGEG MATCH CONSENSUS ?????????????????????????????????MS???????G??D???????SS?PE??

WD42B_HUMAN WD42B_HUMAN SGVAAVTAASSDIEMAATEPS---TGDGGDTRDGGFLNDASTENQNTDSESSSEDVELES B2RXH9_HUMAN B2RXH9_HUMAN SGAVAATEASSDIDIATSELSVTVTGDGSDSRDGGFPNDASTENRSSDQESASEDIELES WD42C_HUMAN WD42C_HUMAN SGAVAATEASSDIDIATSELSVTVTGDGSDSRDGGFPNDASTENRSSDQESASEDIELES Q5RAK2_PONAB Q5RAK2_PONAB SGAEEGRETSSGIEVEASDLSLSLTGD-----DGG-PNRTSTESRGTDTESSGEDKDSDS Q4R6S0_MACFA Q4R6S0_MACFA SGAEEGRETSSGIEVEASDLSLSLTGD-----DGG-PNRTSTESRGTDTESSGEDKDSDS WD42A_PONAB WD42A_PONAB SGAEEGRETSSGIEVEASDLSLSLTGD-----DGG-PNRTSTESRGTDTESSGEDKDSDS B7Z2P6_HUMAN B7Z2P6_HUMAN SGAEEGRETSSGIEVEASDLSLSLTGD-----DGG-PNRTITESRGTDTESSGEDKDSDS B7Z8C9_HUMAN B7Z8C9_HUMAN SGAEEGRETSSGIEVEASDLSLSLTGD-----DGG-PNRT-------------------S WD42A_HUMAN WD42A_HUMAN SGAEEGRETSSGIEVEASDLSLSLTGD-----DGG-PNRTSTESRGTDTESSGEDKDSDS WD42A_MOUSE WD42A_MOUSE SGAEEGRETSSGIEVEASDLSLSLTGD-----DGG-PNRTSTESRGTDTESSGEEKDSDS WD42A_RAT WD42A_RAT SGAEEGRETSSGIEVEASDLSLSLTGD-----DGG-PNRTSTESRGTDTESSGEEKDSDS WD42A_XENLA WD42A_XENLA SGAEEGKENSSGIEVEASDVSLSLTAD-----ETG---TTQAESRDSCSETSGEDKDSDS WD42A_XENTR WD42A_XENTR SGAEEGKENSSGIEVEASDVSLSLTGD-----ETG---TTQAESRDTCSETSGEDKDSDS Q4RWS8_TETNG Q4RWS8_TETNG --------------------------------------------------SSDEDDDDDD Q7T134_DANRE Q7T134_DANRE RGEAETSDASAVAEAQASPESANLNSAA----EGSAVGQDKLMTDSEQKQGPAEEEDTDS MATCH . CONSENSUS SGA????E?SS?IE??AS??S???TGD??????GG???????E??????E???E?????S

WD42B_HUMAN WD42B_HUMAN MGEGLFGYPLVGE----------------------------ETEREEEEEEMEEEGEEEE B2RXH9_HUMAN B2RXH9_HUMAN LED--FEHFLMSGESLFHYPLVGEEETEREEEDEEIQEEGGEEEEEEEEEEEEEEEEEEE WD42C_HUMAN WD42C_HUMAN LED--FEHFLMREEE--------------------------EEEEEEEEEEEEEEEEEEE Q5RAK2_PONAB Q5RAK2_PONAB MKD--TGHYSINDENRVH-----------------------DRSEEEEEEEEEEE---EE Q4R6S0_MACFA Q4R6S0_MACFA MED--TGHYSINDENRVH-----------------------DRSEEEEEEEEEEE---EE WD42A_PONAB WD42A_PONAB MED--TGHYSINDENRVH-----------------------DRSEEEEEEEEEEE---EE B7Z2P6_HUMAN B7Z2P6_HUMAN MED--TGHYSINDENRVH-----------------------DRSEEEEEEEEEEE---EE B7Z8C9_HUMAN B7Z8C9_HUMAN MED--TGHYSINDENRVH-----------------------DRSEEEEEEEEEEE---EE WD42A_HUMAN WD42A_HUMAN MED--TGHYSINDENRVH-----------------------DRSEEEEEEEEEEE---EE WD42A_MOUSE WD42A_MOUSE MED--TGHYSINDESRGH-----------------------GHSDEED----------EE WD42A_RAT WD42A_RAT MED--TGHYSINDENRVH-----------------------GHSDEEEE---------EE WD42A_XENLA WD42A_XENLA MDD--TGHYSINDENRGN-----------------------DQSHSEDEEEEEEEDEEEE WD42A_XENTR WD42A_XENTR MDD--TGHYSINDENRGN-----------------------DQSHSEDEEEEEEEEEDEE Q4RWS8_TETNG Q4RWS8_TETNG DDD--------------------------------------DRKDEDDDDEDEDE----- Q7T134_DANRE Q7T134_DANRE MDG--SGLYSLTEE---------------------------GERESEGGGRGKDEGKRSA MATCH .: CONSENSUS M?D???GH?????E???????????????????????????????EE?E?E?E?E???EE

WD42B_HUMAN WD42B_HUMAN QP-----RMCPRCGGTNHDQCLLDED-------------QALEEWISSETSALPRSRWQV B2RXH9_HUMAN B2RXH9_HUMAN QP-----RAGPQGSGGNHEQYSLEED-------------QALEEWVSSETSALPRPRWQV WD42C_HUMAN WD42C_HUMAN QP-----RAGPQGSGGNHEQYSLEED-------------QALEEWVSSETSALPRPRWQV Q5RAK2_PONAB Q5RAK2_PONAB QP-----RRRVQRKRANRDQDSSDDE-------------RALEDWVSSETSALPRPRWQA Q4R6S0_MACFA Q4R6S0_MACFA QP-----RRRVQRKRANRDQDSSDDE-------------RALEDWVSSETSALPRPRWQA WD42A_PONAB WD42A_PONAB QP-----RRRVQRKRANRDQDSSDDE-------------RALEDWVSSETSALPRPRWQA B7Z2P6_HUMAN B7Z2P6_HUMAN QP-----RRRVQRKRANRDQDSSDDE-------------RALEDWVSSETSALPRPRWQA B7Z8C9_HUMAN B7Z8C9_HUMAN QP-----RRRVQRKRANRDQDSSDDE-------------RALEDWVSSETSALPRPRWQA WD42A_HUMAN WD42A_HUMAN QP-----RRRVQRKRANRDQDSSDDE-------------RALEDWVSSETSALPRPRWQA WD42A_MOUSE WD42A_MOUSE QP-----RHRGQRKRASRDQDSSDDE-------------RALEDWVSSETTALPRPRWQA WD42A_RAT WD42A_RAT QP-----RHRVQRKRASRDQDSSDDE-------------RALEDWVSSETTALPRPRWQA WD42A_XENLA WD42A_XENLA AV---RHRKRAQRKRANRDQESSDEE-------------RALDDWLISEKTPLPPPQWRA WD42A_XENTR WD42A_XENTR EEEAVRHRKRAQRKRANRDQDSSDEE-------------RALEDWVLSEKTPLPRPRWRA Q4RWS8_TETNG Q4RWS8_TETNG -----------------------DDN-------------EAMEAWLGAELQDLRGPVWRA Q7T134_DANRE Q7T134_DANRE RK-----RNRPSGGAAHHSSSSDDDDENEEDDDVEEEDEQAMEAWLGADLCDLSRPSWRA MATCH ::: .*:: *: :: * . *:. CONSENSUS ???????R???Q???????Q?S?D????????????????ALE?W??SE???LPRPRW?A

WD42B_HUMAN WD42B_HUMAN LTALRQRQLG-SSARFVYEACGARTFVQRFRLQYLLGSHAGSVSTIHFNQRGTRLASSGD B2RXH9_HUMAN B2RXH9_HUMAN VTALHQRQLG-SRPRFVYEACGARAFVQRFRLQYRLADHVGCVNTVHFNQRGTRLASSGD WD42C_HUMAN WD42C_HUMAN VTALHQRQLG-SRPRFVYEACGARAFVQRFRLQYRLADHVGCVNTVHFNQRGTRLASSGD Q5RAK2_PONAB Q5RAK2_PONAB LPALRERELG-SSARFVYEACGARVFVQRFRLQHGLEGHTGCVNTLHFNQRGTWLASGSD Q4R6S0_MACFA Q4R6S0_MACFA LPALRERELG-SSARFVYEACGARVFVQRFRLQHGLEGHTGCVNTLHFNQRGTWLASGSD WD42A_PONAB WD42A_PONAB LPALRERELG-SSARFVYEACGARVFVQRFRLQHGLEGHTGCVNTLHFNQRGTWLASGSD B7Z2P6_HUMAN B7Z2P6_HUMAN LPALRERELG-SSARFVYEACGARVFVQRFRLQHGLEGHTGCVNTLHFNQRGTWLASGSD B7Z8C9_HUMAN B7Z8C9_HUMAN LPALRERELG-SSARFVYEACGARVFVQRFRLQHGLEGHTGCVNTLHFNQRGTWLASGSD WD42A_HUMAN WD42A_HUMAN LPALRERELG-SSARFVYEACGARVFVQRFRLQHGLEGHTGCVNTLHFNQRGTWLASGSD WD42A_MOUSE WD42A_MOUSE LPALRERELG-SSARFVYEACGARVFVQRFRLQHGLEGHTGCVNTLHFNQRGTWLASGSD WD42A_RAT WD42A_RAT LPALRERELG-SSARFVYEACGARVFVQRFRLQHGLEGHTGCVNTLHFNQRGTWLASGSD WD42A_XENLA WD42A_XENLA LSALRQRQMG-SSTRFIYEACGARGFVQRFHLLHGLDGHSGCVNTLHFNQRGTCLASGSD WD42A_XENTR WD42A_XENTR LRALRQRQMG-SSTRFIYDACGARGFVQRFRLLHGLDGHSGCVNTLHFNQRGTWLASGSD Q4RWS8_TETNG Q4RWS8_TETNG VPSLRSREIGRDAHQFVRRVCGARGLVQRLELQGRLERHTGCVNTLHFNPSGTRLASGSD Q7T134_DANRE Q7T134_DANRE VPSLRAREIGRDSQQFVRKVCGARGLVQRLELQGRLERHTGCVNTLHFNPSGTRLASGSD MATCH : :*: *::* . :*: .**** :***:.* * * *.*.*:*** ** ***..* CONSENSUS ??ALR?R??G?SS?RFVYEACGAR?FVQRFRLQ??L??H?GCVNTLHFNQRGT?LASGSD

WD42B_HUMAN WD42B_HUMAN DLRVIVWDWVRQKPVLNFESGHDINVI--------------------------------Q B2RXH9_HUMAN B2RXH9_HUMAN DLKVIVWDWVRQRPVLNFESGHTNNVF--------------------------------Q WD42C_HUMAN WD42C_HUMAN DLKVIVWDWVRQRPVLNFESGHTNNVF--------------------------------Q Q5RAK2_PONAB Q5RAK2_PONAB DLKVVVWDWVRRQPVLDFESGHKSNVF--------------------------------Q Q4R6S0_MACFA Q4R6S0_MACFA DLKVVVWDWVRRQPVPDFESGHKSNVF--------------------------------Q WD42A_PONAB WD42A_PONAB DLKVVVWDWVRRQPVLDFESGHKSNVF--------------------------------Q B7Z2P6_HUMAN B7Z2P6_HUMAN DLKVVVWDWVRRQPVLDFESGHKSNVF--------------------------------Q B7Z8C9_HUMAN B7Z8C9_HUMAN DLKVVVWDWVRRQPVLDFESGHKSNVF--------------------------------Q WD42A_HUMAN WD42A_HUMAN DLKVVVWDWVRRQPVLDFESGHKSNVF--------------------------------Q WD42A_MOUSE WD42A_MOUSE DLKVVVWDWVRRQPVLDFESGHKSNVF--------------------------------Q WD42A_RAT WD42A_RAT DLKVVVWDWVRRQPVLDFESGHKSNVF--------------------------------Q WD42A_XENLA WD42A_XENLA DLKVVVWDWVRRKPVLEFESGHKSNVF--------------------------------Q WD42A_XENTR WD42A_XENTR DLKVVVWDWVRRKPVLEFESGHKSNVF--------------------------------Q Q4RWS8_TETNG Q4RWS8_TETNG DLRVVIWDWAVRHAVLEFDSGHKSNVFQVGAKQPCCRGNAATHRNALRSKVCFALIARIQ Q7T134_DANRE Q7T134_DANRE DLRVVIWDWARRKAELEFDSGHKSNVF--------------------------------Q MATCH **:*::***. ::. :*:*** **: * CONSENSUS DLKVVVWDWVRR?PVL?FESGHKSNVF????????????????????????????????Q

WD42B_HUMAN WD42B_HUMAN AKFFPNCGDSTLAMCGHDGQVRVAELINASYCENTKRVAKHRGPAHELALEPDSPYKFLT B2RXH9_HUMAN B2RXH9_HUMAN AKFLPNCGDSTLAMCARDGQVRVAELINASYFNNTKCVAQHRGPAHKLALEPDSPYKFLT WD42C_HUMAN WD42C_HUMAN AKFLPNCGDSTLAMCARDGQVRVAELINASYFNNTKCVAQHRGPAHKLALEPDSPYKFLT Q5RAK2_PONAB Q5RAK2_PONAB AKFLPNSGDSTLAMCARDGQVRVAELSATQCCKNTKRVAQHKGASHKLALEPDSPCTFLS Q4R6S0_MACFA Q4R6S0_MACFA AKFLPNSGDSTLAMCARDGQVRVAELSATQCCKNTKRVAQHKGASHKLALEPDSPCTFLS WD42A_PONAB WD42A_PONAB AKFLPNSGDSTLAMRARDGQVRVAELSATQCCKNTKRVAQHKGASHKLALEPDSPCTFLS B7Z2P6_HUMAN B7Z2P6_HUMAN AKFLPNSGDSTLAMCARDGQVRVAELSATQCCKNTKRVAQHKGASHKLALEPDSPCTFLS B7Z8C9_HUMAN B7Z8C9_HUMAN AKFLPNSGDSTLAMCARDGQVRVAELSATQCCKNTKRVAQHKGASHKLALEPDSPCTFLS WD42A_HUMAN WD42A_HUMAN AKFLPNSGDSTLAMCARDGQVRVAELSATQCCKNTKRVAQHKGASHKLALEPDSPCTFLS WD42A_MOUSE WD42A_MOUSE AKFLPNSGDSTLAMCARDGQVRVAELSATQCCKNTKRVAQHKGASHKLALEPDSPCTFLS WD42A_RAT WD42A_RAT AKFLPNSGDSTLAMCARDGQVRVAELSATQCCKNTKRVAQHKGASHKLALEPDSPCTFLS WD42A_XENLA WD42A_XENLA AKFLPNSGDSTLAMCARDGQVRVAELSATHCCKNTKRVAQHKGASHKLALEPDSPCTFLS WD42A_XENTR WD42A_XENTR AKFLPNSGDSTLAMCARDGQVRVAELSATHCCKNTKRVAQHKGASHKLALERDSPCTFLS Q4RWS8_TETNG Q4RWS8_TETNG AKFLPHSGDSTLAMCARDGQIRVAELSATQCCKNTKRVAQHKGAAHKLALEPDSQCSFLS Q7T134_DANRE Q7T134_DANRE AKFLPHSGDSTLAMCARDGQIRVAELSATQRCKNTKRVAQHKGAAHKLALEPDSPCSFLS MATCH ***:*:.******* .:***:***** : :*** **:*:*.:*:**** ** .**: CONSENSUS AKFLPNSGDSTLAMCARDGQVRVAELSAT??CKNTKRVAQHKGA?HKLALEPDSPC?FLS

WD42B_HUMAN WD42B_HUMAN SGEDAVVFTIDLRQDRPASKVVVTRENDKKVGLYTISMNPANIYQFAVGGHDQFVRIYDQ B2RXH9_HUMAN B2RXH9_HUMAN SGEDAVVFTIDLRQDRPASKVVVTRENDKKVGLYTITVNPANTYQFAVGGQDQFVRIYDQ WD42C_HUMAN WD42C_HUMAN SGEDAVVFTIDLRQDRPASKVVVTRENDKKVGLYTITVNPANTYQFAVGGQDQFVRIYDQ Q5RAK2_PONAB Q5RAK2_PONAB AGEDAVVFTIDLRQDRPASKLVVTKEKEKKVGLYTIYVNPANTHQFAVGGRDQFVRIYDQ Q4R6S0_MACFA Q4R6S0_MACFA AGEDAVVFTIDLRQDRPASKLVVTKEKEKKVGLYTIFVNPANTHQFAVGGRDQFVRIYDQ WD42A_PONAB WD42A_PONAB AGEDAVVFTIDLRQDRPASKLVVTKEKEKKVGLYTIYVNPANTHQFAVGGRDQFVRIYDQ B7Z2P6_HUMAN B7Z2P6_HUMAN AGEDAVVFTIDLRQDRPASKLVVTKEKEKKVGLYTIYVNPANTHQFAVGGRDQFVRIYDQ B7Z8C9_HUMAN B7Z8C9_HUMAN AGEDAVVFTIDLRQDRPASKLVVTKEKEKKVGLYTIYVNPANTHQFAVGGRDQFVRIYDQ WD42A_HUMAN WD42A_HUMAN AGEDAVVFTIDLRQDRPASKLVVTKEKEKKVGLYTIYVNPANTHQFAVGGRDQFVRIYDQ WD42A_MOUSE WD42A_MOUSE AGEDAVVFTIDLRQDRPASKLVVTKEKEKKVGLYTIYVNPANTHQFAVGGRDQYVRIYDQ WD42A_RAT WD42A_RAT AGEDAVVFTIDLRQDRPASKLVVTKEKEKKVGLYTIYVNPANTHQFAVGGRDQFVRIYDQ WD42A_XENLA WD42A_XENLA AGEDAVVFTIDLRQDRPASRLVVTKEKESKVGLYTIYVNPANTYQFAVGGRDQFVRIYDQ WD42A_XENTR WD42A_XENTR AGEDAVVFTIDLRQDRPASRLVVTKEKEKKVGLYTIYVNPANTYQFAVGGRDQFVRIYDQ Q4RWS8_TETNG Q4RWS8_TETNG AGEDAVVFGIDLRLDRPANKLVVVKEGDKKVGLYTIYVNPAKTHHFAVGGRDQYVRIYDQ Q7T134_DANRE Q7T134_DANRE AGEDAVVFGIDLRLDRPANKLVVVKEGEKKVGLYTIYVNPANTHHFAVGGRDQYVRIYDQ MATCH :******* **** ****.::**.:* :.******* :***: ::*****:**:****** CONSENSUS AGEDAVVFTIDLRQDRPASKLVVTKE??KKVGLYTI?VNPANT?QFAVGGRDQFVRIYDQ

WD42B_HUMAN WD42B_HUMAN RRIDKKENNGVLKKFTPHHLVYCDFPTNITCVVYSHDGTELLASYNDEDIYLFNSSLSDG B2RXH9_HUMAN B2RXH9_HUMAN RKIDKKENNGVLKKFTPHHLVNCDFPTNITCVVYSHDGTELLASYNDDDIYLFNSSHSDG WD42C_HUMAN WD42C_HUMAN RKIDKKENNGVLKKFTPHHLVNCDFPTNITCVVYSHDGTELLASYNDDDIYLFNSSHSDG Q5RAK2_PONAB Q5RAK2_PONAB RKIDENENNGVLKKFCPHHLVNSESKANITCLVYSHDGTELLASYNDEDIYLFNSSHSDG Q4R6S0_MACFA Q4R6S0_MACFA RKIDENENNGVLKKFCPHHLVNSESKANITCLVYSHDGTELLASYNDEDIYLFNSSHSDG WD42A_PONAB WD42A_PONAB RKIDENENNGVLKKFCPHHLVNGESKANITCLVYSHDGTELLASYNDEDIYLFNSSHSDG B7Z2P6_HUMAN B7Z2P6_HUMAN RKIDENENNGVLKKFCPHHLVNSESKANITCLVYSHDGTELLASYNDEDIYLFNSSHSDG B7Z8C9_HUMAN B7Z8C9_HUMAN RKIDENENNGVLKKFCPHHLVNSESKANITCLVYSHDGTELLASYNDEDIYLFNSSHSDG WD42A_HUMAN WD42A_HUMAN RKIDENENNGVLKKFCPHHLVNSESKANITCLVYSHDGTELLASYNDEDIYLFNSSHSDG WD42A_MOUSE WD42A_MOUSE RKIDENENNGVLKKFCPHHLVNSESKANITCLVYSHDGTELLASYNDEDIYLFNSSHSDG WD42A_RAT WD42A_RAT RKIDENENNGVLKKFCPHHLVNSESKANITCLVYSHDGTELLASYNDEDIYLFNSSHSDG WD42A_XENLA WD42A_XENLA RKINENVNNGVLKKFCPHHLVTSEAKANITCLVYSHDGSELLASYNDEDIYLFNSSHSDG WD42A_XENTR WD42A_XENTR RKINENVNNGVLKKFCPHHLVTSEAKANITCLVYSHDGSELLASYNDEDIYLFNSSHSDG Q4RWS8_TETNG Q4RWS8_TETNG RKINENDNNGVLKKFCPSHLVSIESKTNITCLVYSHDGTELLASYNDEDIYLFDSNHSDG Q7T134_DANRE Q7T134_DANRE RKINEHDNNGVLKKFCPSHLVSSESKTNITCLVYSHDGTELLASYNDEDIYLFDSSHSDG MATCH *:*::: ******** * *** : :****:******:********:*****:*. *** CONSENSUS RKI?E??NNGVLKKFCPHHLV??E?K?NITCLVYSHDGTELLASYNDEDIYLFNSSHSDG

WD42B_HUMAN WD42B_HUMAN AQYVKRYKGHRNNDT---------------------------------IKCVNFYGPRSE B2RXH9_HUMAN B2RXH9_HUMAN AQYSKRFKGHRNNTT---------------------------------VKGVNFYGPRSE WD42C_HUMAN WD42C_HUMAN AQYSKRFKGHRNNTT---------------------------------VKGVNFYGPRSE Q5RAK2_PONAB Q5RAK2_PONAB AQYVKRYKGHRNNAT---------------------------------VKGVNFYGPKSE Q4R6S0_MACFA Q4R6S0_MACFA AQYVKRYKGHRNNAT---------------------------------VKGVNFYGPKSE WD42A_PONAB WD42A_PONAB AQYVKRYKGHRNNAT---------------------------------VKGVNFYGPKSE B7Z2P6_HUMAN B7Z2P6_HUMAN AQYVKRYKGHRNNAT---------------------------------VKGVNFYGPKSE B7Z8C9_HUMAN B7Z8C9_HUMAN AQYVKRYKGHRNNAT---------------------------------VKGVNFYGPKSE WD42A_HUMAN WD42A_HUMAN AQYVKRYKGHRNNAT---------------------------------VKGVNFYGPKSE WD42A_MOUSE WD42A_MOUSE AQYIKRYKGHRNNAT---------------------------------VKGVNFYGPKSE WD42A_RAT WD42A_RAT AQYIKRYKGHRNNAT---------------------------------VKGVNFYGPKSE WD42A_XENLA WD42A_XENLA AEYIKRYKGHRNNAT---------------------------------VKGVNFYGPRSE WD42A_XENTR WD42A_XENTR AEYIKRYKGHRNNAT---------------------------------VKGVNFYGPRSE Q4RWS8_TETNG Q4RWS8_TETNG ADYLRRYKGHRNNATGVCSASSFPHFWGIARGLTPPPCPPPLSSLRLSVKGVNFYGPCSE Q7T134_DANRE Q7T134_DANRE ADYHRKYKGHRNNAT---------------------------------VKGVNFYGPCSE MATCH *:* :::****** * :* ****** ** CONSENSUS A?Y?KRYKGHRNNAT?????????????????????????????????VKGVNFYGP?SE

WD42B_HUMAN WD42B_HUMAN FVVSGSDCGHVFFWEKSSSQIIQFMEGDRGDIVNCLEPHPYLPVLATSGLDQHVRIWTPT B2RXH9_HUMAN B2RXH9_HUMAN FVVSGSDCGHIFFWEKSSCQIIQFLKGSREGTINCLEPHPYLPVLACSGLDHDVKIWTPT WD42C_HUMAN WD42C_HUMAN FVVSGSDCGHIFFWEKSSCQIIQFLKGSREGTINCLEPHPYLPVLACSGLDHDVKIWTPT Q5RAK2_PONAB Q5RAK2_PONAB FVVSGSDCGHIFLWEKSSCQIIQFMEGDKGGVVSMV------------------------ Q4R6S0_MACFA Q4R6S0_MACFA FVVSGSDCGHIFLWEKSSCQIIQFMEGDKGGLA--------------------------- WD42A_PONAB WD42A_PONAB FVVSGSDCGHIFLWEKSSCQIIQFMEGDKGGVVNCLEPHPHLPVLATSGLDHDVKIWAPT B7Z2P6_HUMAN B7Z2P6_HUMAN FVVSGSDCGHIFLWEKSSCQIIQFMEGDKGGVVNCLEPHPHLPVLATSGLDHDVKIWAPT B7Z8C9_HUMAN B7Z8C9_HUMAN FVVSGSDCGHIFLWEKSSCQIIQFMEGDKGGVVNCLEPHPHLPVLATSGLDHDVKIWAPT WD42A_HUMAN WD42A_HUMAN FVVSGSDCGHIFLWEKSSCQIIQFMEGDKGGVVNCLEPHPHLPVLATSGLDHDVKIWAPT WD42A_MOUSE WD42A_MOUSE FVVSGSDCGHIFLWEKSSCQIIQFMEGDKGGVVNCLEPHPHLPVLATSGLDHDVKIWAPT WD42A_RAT WD42A_RAT FVVSGSDCGHIFLWEKSSCQIIQFMEGDKGGVVNCLEPHPHLPVLATSGLDHDVKIWAPT WD42A_XENLA WD42A_XENLA FVVSGSDCGHIFLWEKSSCQIVQFMDGDKGGVVNCLEPHPHLPVLATSGLDYDVKIWLPT WD42A_XENTR WD42A_XENTR FVVSGSDCGHIFLWEKSSCQIVQFMDGDKGGVVNCLEPHPHLPVLATSGLDYDVKIWLPT Q4RWS8_TETNG Q4RWS8_TETNG FVVSGSDCGHIYLWDKYSARIVQFMEGDKGGVVNCLEPHPHLPGMATSGLDYDIKLWAPT Q7T134_DANRE Q7T134_DANRE FVVSGSDCGHIYLWDKNSARVVQFMEGDRGGVVNCLEPHPHLPGLATSGLDHDVKLWAPT MATCH **********:::*:* *.:::**:.*.: . CONSENSUS FVVSGSDCGHIFLWEKSSCQI?QFM?GD?GG?VNCLEPHP?LP?LA?SGLD?DVK?W?PT

WD42B_HUMAN WD42B_HUMAN AKTATELTGLKDVIKKNKQERDEDNLNYTDSFDNRMLRFFVRHLLQRAHQPGWRDHGAEF B2RXH9_HUMAN B2RXH9_HUMAN AKAATELTGLKKVIKKNKWERDEDSLHHGSLFDQYMLWFLLRHVTQRGRHQDWRSGEAEF WD42C_HUMAN WD42C_HUMAN AKAATELTGLKKVIKKNKWERDEDSLHHGSLFDQYMLWFLLRHVTQRGRHQDWRSGEAEF Q5RAK2_PONAB Q5RAK2_PONAB ------------------------------------------------------------ Q4R6S0_MACFA Q4R6S0_MACFA ------------------------------------------------------------ WD42A_PONAB WD42A_PONAB AEASTELTGLKDVIKKNKRERDEDSLHRTDLFDSHMLWFLMHHLRQRRHHRRWREPGVGA B7Z2P6_HUMAN B7Z2P6_HUMAN AEASTELTGLKDVIKKNKRERDEDSLHQTDLFDSHMLWFLMHHLRQRRHHRRWREPGVGA B7Z8C9_HUMAN B7Z8C9_HUMAN AEASTELTGLKDVIKKNKRERDEDSLHQTDLFDSHMLWFLMHHLRQRRHHRRWREPGVGA WD42A_HUMAN WD42A_HUMAN AEASTELTGLKDVIKKNKRERDEDSLHQTDLFDSHMLWFLMHHLRQRRHHRRWREPGVGA WD42A_MOUSE WD42A_MOUSE AEASTELTGLKEVIKKNKRERDEDSLHHTDLFDSHMLWFLMHHLRQRRHHRRWREPGVGA WD42A_RAT WD42A_RAT AEASTELTGLKDVIKKNKRERDEDSLHHTDLFDSHMLWFLMHHLRQRRHHRRWREPGVGA WD42A_XENLA WD42A_XENLA AKEPTELDGLKEVIKKNKRERDEDSLHHTDLFDNHMLWFLMHHLRQRGQRRRRRDAGLGA WD42A_XENTR WD42A_XENTR AKEPTELNGLKEVIKKNKRERDEDSLHHTDLFDNHMLWFLMHHLRQRGQRRRRRDAGLGA Q4RWS8_TETNG Q4RWS8_TETNG AENPTGLKGLKEV----------------------FLSFL-------------------- Q7T134_DANRE Q7T134_DANRE AENPTTLKGLKEVMKKNKRERDEDNVRHGDQYDTQLLWFLMRHMRNRRPQR--------- MATCH CONSENSUS A???T?L?GLK?V?KKNK?ERDED????????D???L?FL??H???R?????????????

WD42B_HUMAN WD42B_HUMAN PDEEELDESSSTSDTS--EEEGQDRVQCIPS B2RXH9_HUMAN B2RXH9_HUMAN PDEES-DESSSTSETS--EEEVQDRVQCMPS WD42C_HUMAN WD42C_HUMAN PDEES-DESSSTSETS--EEEVQDRVQCMPS Q5RAK2_PONAB Q5RAK2_PONAB ---------------------------C--- Q4R6S0_MACFA Q4R6S0_MACFA ------------------------------- WD42A_PONAB WD42A_PONAB TDADS-DESPSSSDTS-DEEEGPDRVQCMPS B7Z2P6_HUMAN B7Z2P6_HUMAN TDADS-DESPSSSDTS-DEEEGPDRVQCMPS B7Z8C9_HUMAN B7Z8C9_HUMAN TDADS-DESPSSSDTS-DEEEGPDRVQCMPS WD42A_HUMAN WD42A_HUMAN TDADS-DESPSSSDTS-DEEEGPDRVQCMPS WD42A_MOUSE WD42A_MOUSE TDADS-DESPSSSDTS-DEEEGPDRVQCMPS WD42A_RAT WD42A_RAT TDADS-DESPSSSDTS-DEEEGPDRVQCMPS WD42A_XENLA WD42A_XENLA GDAES-DDSPSSSDSSDDDEDGPDRVQCIPS WD42A_XENTR WD42A_XENTR GDADS-DDSPSSSDSSDDDEDGPDRVQCIPS Q4RWS8_TETNG Q4RWS8_TETNG -------GTLHQSDAS--------RLG---- Q7T134_DANRE Q7T134_DANRE ------------------------------- MATCH CONSENSUS ????????????S??S????????R??C???


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