Alignment of the gene Family HBG056624 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
A2ADI4_MOUSE A2ADI4_MOUSE -----------MDDKLHSVKIYVMVEDEQWKGIGAGQISSKYIERLQGVCLIVQSESDGS B2RX57_MOUSE B2RX57_MOUSE -----------MEYRLHTVKVYVMMEDKQWKNVGTGQISSKYSEQLQGVCLLVHSLSDGS SMEK3_MOUSE SMEK3_MOUSE TWPSEARPNINMEYRLHTVKVYVMMEDKQWKNVGTGQISSKYSEQLQGVCLLVHSLSDGS SMEK3_HUMAN SMEK3_HUMAN -----------MAGLRYSVKVYVLNEDEEWNNLGTGQVSSTYDEQFQGMSLLVRSDSDGS PP4R3_DANRE PP4R3_DANRE -----------MTDTRRRVKVYTLNEDRQWDDRGTGHVSSAYVERLKGMSLLVRAESDGS PP4R3_TETNG PP4R3_TETNG -----------MTDTRRRVKVYTLNEDRQWDDRGTGHVSSGYVERFKGTSLLVRAESDGS PP4R3_XENLA PP4R3_XENLA -----------MTDTRRRVKVYTLNEDRQWDDRGTGHVSSGYVERLKGMSLLVRAESDGS A8SMA7_BOVIN A8SMA7_BOVIN -----------MTDTRRRVKVYTLNEDRQWDDRGTGHVSSGYVERLKGMSLLVRAESDGS P4R3A_MOUSE P4R3A_MOUSE -----------MTDTRRRVKVYTLNEDRQWDDRGTGHVSSGYVERLKGMSLLVRAESDGS P4R3A_HUMAN P4R3A_HUMAN -----------MTDTRRRVKVYTLNEDRQWDDRGTGHVSSGYVERLKGMSLLVRAESDGS Q71SA2_BOVIN Q71SA2_BOVIN -----------MTDTRRRVKVYTLNEDRQWDDRGTGHVSSGYVERLKGMSLLVRAESDGS Q6P100_DANRE Q6P100_DANRE -----------MSDTRRRVKVYTLNEERQWEDRGTGHVCCS----AEDTALSVTAESDGS Q4SQL5_TETNG Q4SQL5_TETNG -----------MSDTRRRVKVYTLNEDRQWDDRGTGHVSSPFVERLKGISLLVRAESDGS P4R3A_XENLA P4R3A_XENLA -----------MSDTRRRVKVYTLNEDRQWDDRGTGHVSSTYVERLKGMSLLVRAESDGS PP4R3_XENTR PP4R3_XENTR -----------MSDTRRRVKVYTLNEDRQWDDRGTGHVSSTYVERLKGMSLLVRAESDGS P4R3B_XENLA P4R3B_XENLA -----------MSDTRRRVKVYTLNEDRQWDDRGTGHVSSTYVDRLKGMSLLVRAESDGS B4DKA9_HUMAN B4DKA9_HUMAN -----------MSDTRRRVKVYTLNEDRQWDDRGTGHVSSTYVEELKGMSLLVRAESDGS P4R3B_HUMAN P4R3B_HUMAN -----------MSDTRRRVKVYTLNEDRQWDDRGTGHVSSTYVEELKGMSLLVRAESDGS P4R3B_MOUSE P4R3B_MOUSE -----------MSDTRRRVKVYTLNEDRQWDDRGTGHVSSTYVEELKGMSLLVRAESDGS Q3V166_MOUSE Q3V166_MOUSE ----------MTPDSRAAL---------------------------------------GS MATCH : ** CONSENSUS ???????????M?D?R??VKVY?LNED?QW???GTG?VSS?Y?E?L?G??LLV??ESDGS

A2ADI4_MOUSE A2ADI4_MOUSE LIMECKIHPNVPYHKQRGEIIIWSETKNHGMAIHFQEPNGCQEIWEDICQVQGKDPNVEI B2RX57_MOUSE B2RX57_MOUSE PIMECKIHPNVPYQKQQGKIIIWSEAKNHGMAIHFQEPNDCQEIWEDICQIQGKDPHVEI SMEK3_MOUSE SMEK3_MOUSE PIMECKIHPNVPYQKQQGKIIIWSEAKNHGMAIHFQEPNDCQEIWEDICQIQGKDPHVEI SMEK3_HUMAN SMEK3_HUMAN VILRSQIPPDRPYGKYQETLIVWYEAENQGLVLKFQDPAGCQDIWKEICQAQGKDPSIQT PP4R3_DANRE PP4R3_DANRE LLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVDI PP4R3_TETNG PP4R3_TETNG LLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVDI PP4R3_XENLA PP4R3_XENLA LLLESKINTNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVDI A8SMA7_BOVIN A8SMA7_BOVIN LLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVDI P4R3A_MOUSE P4R3A_MOUSE LLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVDI P4R3A_HUMAN P4R3A_HUMAN LLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVDI Q71SA2_BOVIN Q71SA2_BOVIN LLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVDI Q6P100_DANRE Q6P100_DANRE LLLESKIKPSTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVEI Q4SQL5_TETNG Q4SQL5_TETNG LLLESKISPNTAYQKQQDTLIVWSEADNYDLALSFQEKAGCDEIWEKICQA--------- P4R3A_XENLA P4R3A_XENLA LLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVEV PP4R3_XENTR PP4R3_XENTR LLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVEV P4R3B_XENLA P4R3B_XENLA LLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVDV B4DKA9_HUMAN B4DKA9_HUMAN LLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKADCDEIWEKICQVQGKDPSVEV P4R3B_HUMAN P4R3B_HUMAN LLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVEV P4R3B_MOUSE P4R3B_MOUSE LLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVEV Q3V166_MOUSE Q3V166_MOUSE LLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVEV MATCH ::..:* .. .* * : :*:* *:.* .:.: **: .*::**:.*** CONSENSUS LLLESKI?PNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSV??

A2ADI4_MOUSE A2ADI4_MOUSE TEELTDNLKT--FEELLPIWNLVEMQNCELHTLENIADLFTFVHETPSH-KERLVLVLEK B2RX57_MOUSE B2RX57_MOUSE TQELTDDLET--FEHMPLIWNWVEMSNCEIHTLKNIAELFPFVFEMPSQ-KERLALFLEN SMEK3_MOUSE SMEK3_MOUSE TQELTDDLET--FEHMPLIWNWVEMSNCEIHTLKNIAELFPFVFEMPSQ-KERLALFLEN SMEK3_HUMAN SMEK3_HUMAN TVNISDEPEED-FNEMSVISNMVVLPDCELNTLDQIADIVTSVFSSPVTDRERLAEILKN PP4R3_DANRE PP4R3_DANRE TQELIDESEEERFDDM--SSPGLELPPCELSRLEEVAELVASSLPSPLR-REKLALALEN PP4R3_TETNG PP4R3_TETNG TQDVVDESEDERFDDM--SSPGLELPPCELNRLEDLAELVASSLPSPLR-REKLALAVEN PP4R3_XENLA PP4R3_XENLA TQDLVDESEEERFDDM--SSPGLELPSCELSRLEEIAEVVASSLPSPLR-REKLAVALEN A8SMA7_BOVIN A8SMA7_BOVIN TQDLVDESEEERFDDM--SSPGLELPSCELSRLEEIAELVASSLPSPLR-REKLALALEN P4R3A_MOUSE P4R3A_MOUSE TQDLVDESEEERFDDM--SSPGLELPSCELSRLEEIAELVASSLPSPLR-REKLALALEN P4R3A_HUMAN P4R3A_HUMAN TQDLVDESEEERFDDM--SSPGLELPSCELSRLEEIAELVASSLPSPLR-REKLALALEN Q71SA2_BOVIN Q71SA2_BOVIN TQDLVDESEEERFDDM--SSPGLELPSCELSRLEEIAELVASSLPSPLR-REKLALALEN Q6P100_DANRE Q6P100_DANRE TQEPVDESEEERCEDSGAECDALDLPECVPERLQELAELVSSVLPSPVR-REKLALALVS Q4SQL5_TETNG Q4SQL5_TETNG ------------------------------------------------------------ P4R3A_XENLA P4R3A_XENLA TQDPIDESEEERFEEMPETSNLIDLPTCELGKLEEIADLVTSVLSSPIR-REKLALALEN PP4R3_XENTR PP4R3_XENTR TQDPIDESEEERFEEMPETSNLIDLPTCELSKLEEIADLVTSVLSSPIR-REKLALALEN P4R3B_XENLA P4R3B_XENLA TQDPIDESEEERFEEMPETSNLIDLPTCELGKLEEIADLVTSVLSSPIR-REKLALVLEN B4DKA9_HUMAN B4DKA9_HUMAN TQDLIDESEEERFEEMPETSHLIDPPTCELNKPEEIADLVTSVLSSPIR-REKLALALEN P4R3B_HUMAN P4R3B_HUMAN TQDLIDESEEERFEEMPETSHLIDLPTCELNKLEEIADLVTSVLSSPIR-REKLALALEN P4R3B_MOUSE P4R3B_MOUSE TQDLIDESEEERFEEMPETSHLIDLPACELSKLEEIADLVTSVLSSPIR-REKLALALEN Q3V166_MOUSE Q3V166_MOUSE TQDLIDESEEERFEEMPETSHLIDLPACELSKLEEIADLVTSVLSSPIR-REKLALALEN MATCH CONSENSUS TQ???DE?E???F??M?????????P?CEL??L??IA?LV?S???SP???RE?LAL?LEN

A2ADI4_MOUSE A2ADI4_MOUSE GVYIKKLLQHFNTCEKLKNMESLYYLNNIIKGILFLDNTHLFNIMFSDEFFMDMVGCLEY B2RX57_MOUSE B2RX57_MOUSE EGYIKKLLQLFHTCEKLKNMEGLYYLHNIIKGILFLNNTRLFNIMFSDEFFMDIVGCLEY SMEK3_MOUSE SMEK3_MOUSE EGYIKKLLQLFHTCEKLKNMEGLYYLHNIIKGILFLNNTRLFNIMFSDEFFMDIVGCLEY SMEK3_HUMAN SMEK3_HUMAN EAYIPKLLQLFHTCENLENTEGLHHLYEIIKGILFLNEACLFEIMFSDECIMDVVGCLEY PP4R3_DANRE PP4R3_DANRE EGYIRKLLELFRVCEDLENREGLHHLYDIIKGIFLLNRTALFEVMFSEECIMDVIGCLEF PP4R3_TETNG PP4R3_TETNG EGYIRKLLDLFHVCEDLENREGLHHIYEIIKGIFLLNRTALFEVMFSDECIMDVIGCLEF PP4R3_XENLA PP4R3_XENLA EGYLKKLLELFHVCEDLENIEGLHHLYEVIKGIFLLNRTALFEVMFSEDCMMDIIGCLEY A8SMA7_BOVIN A8SMA7_BOVIN EGYIKKLLELFHVCEDLENIEGLHHLYEIIKGIFLLNRTALFEVMFSEECIMDVIGCLEY P4R3A_MOUSE P4R3A_MOUSE EGYIKKLLELFHVCEDLENIEGLHHLYEIIKGIFLLNRTALFEVMFSEECIMDVIGCLEY P4R3A_HUMAN P4R3A_HUMAN EGYIKKLLELFHVCEDLENIEGLHHLYEIIKGIFLLNRTALFEVMFSEECIMDVIGCLEY Q71SA2_BOVIN Q71SA2_BOVIN EGYIKKLLELFHVCEDLENIEGLHHLYEIIKGIFLLNRTALFEVMFSEECIMDVIGCLEY Q6P100_DANRE Q6P100_DANRE GGYLRQLLLLFRRCEEQENRPRLQQLFQILRGLLFLNKAALFEVLFSDDCIMDVVGCLEY Q4SQL5_TETNG Q4SQL5_TETNG ------------------------------------------------------------ P4R3A_XENLA P4R3A_XENLA EGYIKKLLQLFQTCENLDNTEGLHHLYEIIRGILFLNKAALFEVMFSDECIMDVVGCLEY PP4R3_XENTR PP4R3_XENTR EGYIKKLLQLFQTCENLDNTEGLHHLYEIIRGILFLNKAALFEVMFSDECIMDVVGCLEY P4R3B_XENLA P4R3B_XENLA EGYIKKLLQLFQTCENLDNTEGLHHLYEIIRGILFLNKAALFEVMFSDECIMDVVGCLEY B4DKA9_HUMAN B4DKA9_HUMAN EGYIKKLLQLFQACENLENTEGLHHLYEIIRGILFLNKATLSEVMFSDECIMDVVGCLEY P4R3B_HUMAN P4R3B_HUMAN EGYIKKLLQLFQACENLENTEGLHHLYEIIRGILFLNKATLFEVMFSDECIMDVVGCLEY P4R3B_MOUSE P4R3B_MOUSE EGYIKKLLQLFQACENLENTEGLHHLYEIIRGILFLNKATLFEVMFSDECIMDVVGCLEY Q3V166_MOUSE Q3V166_MOUSE EGYIKKLLQLFQACENLENTEGLHHLYEIIRGILFLNKATLFEVMFSDECIMDVVGCLEY MATCH CONSENSUS EGYI?KLL?LF??CE?L?N?EGL??L??II?GI??LN???LFE?MFS?EC?MD??GCLEY

A2ADI4_MOUSE A2ADI4_MOUSE DPALDHPKQYREFLTQNAKFKEILPITHFQLRQTIQQTYRMQYVHDIVLPIPSICESNLL B2RX57_MOUSE B2RX57_MOUSE DPALDQPKQYREFLTQNSKFKEVIPIIHSQLRQKIQQTYRMQYVHDIMLPTPSIFQTNLL SMEK3_MOUSE SMEK3_MOUSE DPALDQPKQYREFLTQNSKFKEVIPIIHSQLRQKIQQTYRMQYVHDIMLPTPSIFQTNLL SMEK3_HUMAN SMEK3_HUMAN DPALDQPKRHRDFLTNDAKFKEVIPITNSELRQKIHQTYRLQYIYDILLPVPSIFEDNFL PP4R3_DANRE PP4R3_DANRE DPSLPQPRRHREFLTTTARFKEVIPISDPELRQKIHQTYRVQYIQDMVLPTPSVFEENML PP4R3_TETNG PP4R3_TETNG DPALPQPRRHREFLTKTAHFKEVIPISDPELRQKIHQTYRVQYIQDMVLPTPSVFEENML PP4R3_XENLA PP4R3_XENLA DPSLPTQRKHREFLTKTAKFKEVIPISDPELKQKIHQTYRVQYIQDVVLPTPSVFEENML A8SMA7_BOVIN A8SMA7_BOVIN DPALSQPRKHREFLTKTAKFKEVIPISDPELKQKIHQTYRVQYIQDMVLPTPSVFEENML P4R3A_MOUSE P4R3A_MOUSE DPTLSQPRKHREFLTKTAKFKEVIPISDPELKQKIHQTYRVQYIQDMVLPTPSVFEENML P4R3A_HUMAN P4R3A_HUMAN DPALSQPRKHREFLTKTAKFKEVIPISDPELKQKIHQTYRVQYIQDMVLPTPSVFEENML Q71SA2_BOVIN Q71SA2_BOVIN DPALSQPRKHREFLTKTAKFKEVIPISDPELKQKIHQTYRVQYIQDMVLPTPSVFEENML Q6P100_DANRE Q6P100_DANRE DPALLQPKRHRDFLTKTARFREVIPIQDSELRQKIHQTYRVQYIQDIILPTPSVFEENFL Q4SQL5_TETNG Q4SQL5_TETNG --TLVQPKHHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQYIQDIILPTPSVFEENFL P4R3A_XENLA P4R3A_XENLA DPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQYIQDVILPTPSVFEENFL PP4R3_XENTR PP4R3_XENTR DPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQYIQDVILPTPSVFEENFL P4R3B_XENLA P4R3B_XENLA DPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQYIQDVILPTPSVFEENFL B4DKA9_HUMAN B4DKA9_HUMAN DPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQYIQDIILPTPSVFEENFL P4R3B_HUMAN P4R3B_HUMAN DPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQYIQDIILPTPSVFEENFL P4R3B_MOUSE P4R3B_MOUSE DPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQYIQDIILPTPSVFEENFL Q3V166_MOUSE Q3V166_MOUSE DPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQYIQDIILPTPSVFEENFL MATCH :* :::*:*** ::*:*::** . :*:*.*:****:**: *::** **: : *:* CONSENSUS DPAL?QP??HREFLT?TAKFKEVIPI?D?EL?QKIHQTYRVQYIQD??LPTPSVFEEN?L

A2ADI4_MOUSE A2ADI4_MOUSE YGLNTMIIYNKIEIITMLQDDENFLLEVLARLKDNTVGNDRRHELLLFFKEFCTFAKTLE B2RX57_MOUSE B2RX57_MOUSE SDITTMIFFNKINIITMIQEDENFLLEVFSQLKDNSIGDERRIELLLFLKEFCEFAKTLQ SMEK3_MOUSE SMEK3_MOUSE SDITTMIFFNKINIITMIQEDENFLLEVFSQLKDNSIGDERRIELLLFLKEFCEFAKTLQ SMEK3_HUMAN SMEK3_HUMAN STLTTFIFSNKAEIVSMLQKDHKFLYEVFAQLKDETTHDDRRCELLFFFKELCSFSQALQ PP4R3_DANRE PP4R3_DANRE STLHSFIFFNKVEIVGMLQDDEKFLTELFAQLTDEATDDDKRHELVNFLKEFCAFSQTLQ PP4R3_TETNG PP4R3_TETNG STLHSFIFFNKVEIVGMLQDDEKFLTDLFAQLTDEATDDDKRHELVNFLKEFCAFSQTLQ PP4R3_XENLA PP4R3_XENLA STLHSFIFFNKVEIVGMLQEDEKFLTELFAHLTDEATDDEKRQELVNFLKEFCAFSQTLQ A8SMA7_BOVIN A8SMA7_BOVIN STLHSFIFFNKVEIVGMLQEDEKFLTDLFAQLTDEATDEEKRQELVNFLKEFCAFSQTLQ P4R3A_MOUSE P4R3A_MOUSE STLHSFIFFNKVEIVGMLQEDEKFLTDLFAQLTDEATDEEKRQELVNFLKEFCAFSQTLQ P4R3A_HUMAN P4R3A_HUMAN STLHSFIFFNKVEIVGMLQEDEKFLTDLFAQLTDEATDEEKRQELVNFLKEFCAFSQTLQ Q71SA2_BOVIN Q71SA2_BOVIN STLHSFIFFNKVEIVGMLQEDEKFLTDLFAQLTDEATDEEKRQELVNFLKEFCAFSQTLQ Q6P100_DANRE Q6P100_DANRE STLSSFIFFNKVEIVSMLQEDEKFLTEVFAQLTDESTEDSKRRELVNFFKEFCAFSQTLQ Q4SQL5_TETNG Q4SQL5_TETNG STLTSFIFFNKVEIVSMLQEDEKFLTEVFAQLTDEATDDSKRRELVNFVKEFCAFSQTLQ P4R3A_XENLA P4R3A_XENLA STLTSFIFFNKVEIVSMLQEDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQ PP4R3_XENTR PP4R3_XENTR STLTSFIFFNKVEIVSMLQEDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQ P4R3B_XENLA P4R3B_XENLA STLTSFIFFNKVEIVSMLQEDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQ B4DKA9_HUMAN B4DKA9_HUMAN STLTSFIFFNKVEIVSMLQEDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQ P4R3B_HUMAN P4R3B_HUMAN STLTSFIFFNKVEIVSMLQEDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQ P4R3B_MOUSE P4R3B_MOUSE STLTSFIFFNKVEIVSMLQEDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQ Q3V166_MOUSE Q3V166_MOUSE STLTSFIFFNKVEIVSMLQEDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQ MATCH : ::*: ** :*: *:*.*.:** :::::*.*:: :.:* **: *.**:* *:::*: CONSENSUS STL?SFIFFNKVEIV?MLQEDEKFL???FAQLTDE?T???KR?ELVNF?KEFCAFSQTLQ

A2ADI4_MOUSE A2ADI4_MOUSE NLEKHELLKTLINLGVMSALKAVVHMHDYQIQIAALDIFPYLVEYNPCLVREYLLDEAHD B2RX57_MOUSE B2RX57_MOUSE SQKKNELLKTLIKLGIMSVLKVVVHMNDYQIQVGALDIFAYLVEYSPCLVRAYAMEEAQD SMEK3_MOUSE SMEK3_MOUSE SQKKNELLKTLIKLGIMSVLKVVVHMNDYQIQVGALDIFAYLVEYSPCLVRAYAMEEAQD SMEK3_HUMAN SMEK3_HUMAN PQSKDALFETLIQLGVLPALKIVMIRDDLQVRSAAAVICAYLVEYSPSRIREFIISEAHV PP4R3_DANRE PP4R3_DANRE PQNRDAFFKTLSNMGILQALEVILGMDDVQVRGAATDIFSYLVEYNPSMVREFVMQESQQ PP4R3_TETNG PP4R3_TETNG PQNRDAFFKTLSNMGILPALEVILGMDDVQVRAAATDIFSYLVEYNPSMVREFVMQESQQ PP4R3_XENLA PP4R3_XENLA PQNRDAFFKTLSNMGILPALEVILGMDDPQVRSAATDIFSYLVEYNPSMVREFVMQEAQQ A8SMA7_BOVIN A8SMA7_BOVIN PQNRDAFFKTLSNMGILPALEVILGMDDTQVRSAATDIFSYLVEYNPSMVREFVMQEAQQ P4R3A_MOUSE P4R3A_MOUSE PQNRDAFFKTLSNMGILPALEVILGMDDTQVRSAATDIFSYLVEYNPSMVREFVMQEAQQ P4R3A_HUMAN P4R3A_HUMAN PQNRDAFFKTLSNMGILPALEVILGMDDTQVRSAATDIFSYLVEYNPSMVREFVMQEAQQ Q71SA2_BOVIN Q71SA2_BOVIN PQNRDAFFKTLSNMGILPALEVILGMDDTQVRSAATDIFSYLVEYNPSMVREFVMQEAQQ Q6P100_DANRE Q6P100_DANRE PQNRDAFFKTLANLGILPALEIVMGMDDVQVKAAATDIFSYLVEFSPSMVREFVMQEPQQ Q4SQL5_TETNG Q4SQL5_TETNG PQNRDAFFKTLANLGILPALEIVMGMDDLQVRAAATDIFSYLVEFSPSMVREFVMQEPQQ P4R3A_XENLA P4R3A_XENLA PQNRDAFFKTLANLGILPALEIVMGMDDLQVRAAATDIFSYLVEFSPSMVREFVMQEAQQ PP4R3_XENTR PP4R3_XENTR PQNRDAFFKTLANLGILPALEIVMGMDDLQVRAAATDIFSYLVEFSPSMVREFVMQEAQQ P4R3B_XENLA P4R3B_XENLA PQNRDAFFKTLANLGILPALEIVMGMDDLQVRAAATDIFSYLVEFSPSMVREFVMQEAQQ B4DKA9_HUMAN B4DKA9_HUMAN PQNRDAFFKTLAKLGILPALEIVMGMDDLQVRSAAIDIFSYLVEFSPSMVREFVMQEAQQ P4R3B_HUMAN P4R3B_HUMAN PQNRDAFFKTLAKLGILPALEIVMGMDDLQVRSAATDIFSYLVEFSPSMVREFVMQEAQQ P4R3B_MOUSE P4R3B_MOUSE PQNRDAFFKTLAKLGILPALEIVMGMDDLQVRSAATDIFSYLVEFSPSMVREFVMQEAQQ Q3V166_MOUSE Q3V166_MOUSE PQNRDAFFKTLAKLGILPALEIVMGMDDLQVRSAATDIFSYLVEFSPSMVREFVMQEAQQ MATCH .:. :::** ::*:: .*: :: .* *:: .* * .****:.*. :* : :.*.: CONSENSUS PQNRDAFFKTL???GILPALE???GMDD?QVR?AA?DIFSYLVE??PSMVREFVMQEAQQ

A2ADI4_MOUSE A2ADI4_MOUSE TDD-------------DDLFLNIMIKQMICNSDPRFSQGIILPAILCALLDPENMHVTAN B2RX57_MOUSE B2RX57_MOUSE SED------------NDDLLINIMIKQMICDFDPEFSQGIIMTAVLHELLNPENMRTTAK SMEK3_MOUSE SMEK3_MOUSE SED------------NDDLLINIMIKQMICDFDPEFSQGIIMTAVLHELLNPENMRTTAK SMEK3_HUMAN SMEK3_HUMAN CKD-------------SDLFINVIIKQMICDTDPELGGAVHLMVVLHTLLDPRNMLTTPE PP4R3_DANRE PP4R3_DANRE NDD-------------DILLINLIIEHMICDTDPELGGAVQLMGLLRTLVDPENMLATAN PP4R3_TETNG PP4R3_TETNG NDD-------------DILLINLIIEHMICDTDPELGGAVQLISLLRTLVDPENMLATAN PP4R3_XENLA PP4R3_XENLA NDD-------------DILLINLIIEHMICDTDPELGGAVQLTGLLRTLVDPENMLATTN A8SMA7_BOVIN A8SMA7_BOVIN NDD-------------DILLINLIIEHMICDTDPELGGAVQLMGLLRTLVDPENMLATAN P4R3A_MOUSE P4R3A_MOUSE NDD-------------DILLINLIIEHMICDTDPELGGAVQLMGLLRTLVDPENMLATAN P4R3A_HUMAN P4R3A_HUMAN NDDVSKKLTEQKITSKDILLINLIIEHMICDTDPELGGAVQLMGLLRTLVDPENMLATAN Q71SA2_BOVIN Q71SA2_BOVIN NDDVSKKLTEQKITNKDILLINLIIEHMICDTDPELGGAVQLMGLLRTLVDPENMLATAN Q6P100_DANRE Q6P100_DANRE ADD-------------DVLLINVVIKQMICDSDPELGGAVQLMGLLRTLIDPENMLAPSN Q4SQL5_TETNG Q4SQL5_TETNG TDD-------------DVLLINVVIKQMICDSDPELGGAVQLMGLLRTLIDPENMLASTN P4R3A_XENLA P4R3A_XENLA SDD-------------DILLINVVIEQMICDSDPELGGAVQLMGLLRTLIDPENMLATAN PP4R3_XENTR PP4R3_XENTR SDD-------------DILLINVVIEQMICDSDPELGGAVQLMGLLRTLIDPENMLATAN P4R3B_XENLA P4R3B_XENLA SDD-------------DILLINVVIEQMICDSDPELGGAVQLMGLLRTLIDPENMLATAN B4DKA9_HUMAN B4DKA9_HUMAN SDD-------------DILLINVVIEQMICDTDPELGGAVQLMGLLRTLIDPENMLATTN P4R3B_HUMAN P4R3B_HUMAN SDD-------------DILLINVVIEQMICDTDPELGGAVQLMGLLRTLIDPENMLATTN P4R3B_MOUSE P4R3B_MOUSE SDD-------------DVLLINVVIEQMICDTDPELGGAVQLMGLLRTLIDPENMLATTN Q3V166_MOUSE Q3V166_MOUSE SDD-------------DVLLINVVIEQMICDTDPELGGAVQLMGLLRTLIDPENMLATTN MATCH .* . *::*::*::***: **.:. .: : :* *::*.** ...: CONSENSUS ?DD?????????????D?LLIN??I??MICD?DPELGGAVQL??LLRTL?DPENMLAT?N

A2ADI4_MOUSE A2ADI4_MOUSE GCEEKEFLNFFYTRCINNLIAPILSATVEKENAN-------------------------- B2RX57_MOUSE B2RX57_MOUSE GCERKVFLNFFYKRYMRKLIAPILSIRVKYDSND-------------------------- SMEK3_MOUSE SMEK3_MOUSE GCERKVFLNFFYKRYMRKLIAPILSIRVKYDSND-------------------------- SMEK3_HUMAN SMEK3_HUMAN KSERSEFLHFFYKHCMHKFTAPLLAATSEHNCEE-------------------------- PP4R3_DANRE PP4R3_DANRE KTEKTEFLSFFYKHCMHVLSAPLLANTTEEKPSK-------------------------- PP4R3_TETNG PP4R3_TETNG KTEKTEFLSFFYKHCMHVLSAPLLANTTEDKPSK-------------------------- PP4R3_XENLA PP4R3_XENLA KTEKTEFLGFFYKHCMHVLTAPLLANTTEEKPSK-------------------------- A8SMA7_BOVIN A8SMA7_BOVIN KTEKTEFLGFFYKHCMHVLTAPLLANTTEDKPSK-------------------------- P4R3A_MOUSE P4R3A_MOUSE KTEKTEFLGFFYKHCMHVLTAPLLANTTEDKPSK-------------------------- P4R3A_HUMAN P4R3A_HUMAN KTEKTEFLGFFYKHCMHVLTAPLLANTTEDKPSK-------------------------- Q71SA2_BOVIN Q71SA2_BOVIN KTEKTEFLGFFYKHCMHVLTAPLLANTTEDKPSK-------------------------- Q6P100_DANRE Q6P100_DANRE KTEKSEFLSFFYKYCMHVLTAPLLANTAEEDQDL-------------------------- Q4SQL5_TETNG Q4SQL5_TETNG KTEKTEFLSFFYKYCMHVLTAPLLANTAHDKNPK--VLGTCGLLLIIVCCGVS------- P4R3A_XENLA P4R3A_XENLA KTEKSEFLNFFYNHCMHVLTAPLLANTSEDKLEK-------------------------- PP4R3_XENTR PP4R3_XENTR KTEKSEFLNFFYNHCMHVLTAPLLANTSEDKLEK-------------------------- P4R3B_XENLA P4R3B_XENLA KTEKSEFLNFFYNHCMHVLTAPLLANTAEDKLEK-------------------------- B4DKA9_HUMAN B4DKA9_HUMAN KTEKSEFLNFFYNHCMHVLTAPLLTNTSEDKCEKDFFLKHYRYSWSFVCTPSHSHSHSTP P4R3B_HUMAN P4R3B_HUMAN KTEKSEFLNFFYNHCMHVLTAPLLTNTSEDKCEKDFFLKHYRYSWSFVCTPSHSHSHSTP P4R3B_MOUSE P4R3B_MOUSE KTEKSEFLNFFYNHCMHVLTAPLLTNTSEDKCEK-------------------------- Q3V166_MOUSE Q3V166_MOUSE KTEKSEFLNFFYNHCMHVLTAPLLTNTSEDKCEK-------------------------- MATCH *.. ** ***. :. : **:*: . . CONSENSUS KTEK?EFL?FFY??CMHVL?APLL?NT?E???????????????????????????????

A2ADI4_MOUSE A2ADI4_MOUSE -------------NRANICPDNYQNAQLLGVVIEILTFCVQYHSTYIKSYILDNNLLSRI B2RX57_MOUSE B2RX57_MOUSE -------------NRVYICPDNYQNAQLLGAVLEILTFCVQYHSMYIKHYIFSNNLLRSI SMEK3_MOUSE SMEK3_MOUSE -------------NRVYICPDNYQNAQLLGAVLEILTFCVQYHSMYIKHYIFSNNLLRSI SMEK3_HUMAN SMEK3_HUMAN ------DDIAGYDKSKN-CPNDNQTAQLLALILELLTFCIQHHTFYIRSYILNKDLLRKA PP4R3_DANRE PP4R3_DANRE --------------------DDFQTCQLLALIVELLTFCVEHHTYHIKNYIINKDILRRV PP4R3_TETNG PP4R3_TETNG --------------------DDFQTSQLLALILELLTFCVEHHTYHIKNYIINKDILRRV PP4R3_XENLA PP4R3_XENLA --------------------DDFQAAQLLALILELLTFCVEHHTYHIKNYIINKDILRRV A8SMA7_BOVIN A8SMA7_BOVIN --------------------DDFQTAQLLALVLELLTFCVEHHTYHIKNYIINKDILRRV P4R3A_MOUSE P4R3A_MOUSE --------------------DDFQTAQLLALVLELLTFCVEHHTYHIKNYIINKDILRRV P4R3A_HUMAN P4R3A_HUMAN --------------------DDFQTAQLLALVLELLTFCVEHHTYHIKNYIINKDILRRV Q71SA2_BOVIN Q71SA2_BOVIN --------------------DDFQTAQLLALVLELLTFCVEHHTYHIKNYIINKDILRRV Q6P100_DANRE Q6P100_DANRE --------DEGSAKVNPVCPDNFQTAQLLALILELLTFCVEHHTYHIKNYIMTRDLLRRV Q4SQL5_TETNG Q4SQL5_TETNG ------DLQEGSAKINPVCPDNFQTAQLLALILELLTFCVEHHTYHIKTYIMNKDLLRRV P4R3A_XENLA P4R3A_XENLA ------DAVFGSIKTSTVCPDNYQTAQLLALILELLTFCVEHHTYHIKNYIMNKDLLRRV PP4R3_XENTR PP4R3_XENTR ------DAVLGSIKTSTVCPDNYQTAQLLALILELLTFCVEHHTYHIKNYIMNKDLLRRV P4R3B_XENLA P4R3B_XENLA ------DAVLGSIKTSTVCPDNFQTAQLLALILELLTFCVEHHTYHIKNYIMNKDLLRRV B4DKA9_HUMAN B4DKA9_HUMAN SSSISQDNIVGSNKNNTICPDNYQTAQLLALILELLTFCVEHHTYHIKNYIMNKDLLRRV P4R3B_HUMAN P4R3B_HUMAN SSSISQDNIVGSNKNNTICPDNYQTAQLLALILELLTFCVEHHTYHIKNYIMNKDLLRRV P4R3B_MOUSE P4R3B_MOUSE ------DNMLGSNTTNTICPDNYQTAQLLALILELLTFCVEHHTYHIKNYIMNKDLLRRV Q3V166_MOUSE Q3V166_MOUSE ------DNMLGSNTTNTICPDNYQTAQLLALILELLTFCVEHHTYHIKNYIMNKDLLRRV MATCH :: * .***. ::*:****:::*: :*: **: .::* CONSENSUS ????????????????????D??QTAQLLAL?LELLTFCVEHHTYHIK?YI?NKD?LRRV

A2ADI4_MOUSE A2ADI4_MOUSE LVLMTSKHTFLILC---------------------------AVRFMRKLIGLKDEIYNLY B2RX57_MOUSE B2RX57_MOUSE LVLMSSKHTFLILC---------------------------AVRFMRKIIGLKDKMYNHY SMEK3_MOUSE SMEK3_MOUSE LVLMSSKHTFLILC---------------------------AVRFMRKIIGLKDKMYNHY SMEK3_HUMAN SMEK3_HUMAN LILMNSKHTHLILC---------------------------VLRFMRRMICLNDEAYNNY PP4R3_DANRE PP4R3_DANRE LVLTASQHAFLALC---------------------------ALRFMRKIIGLKDEFYNRY PP4R3_TETNG PP4R3_TETNG LVLTASKHAFLALC---------------------------ALRFMRRIIGLKDEFYNRY PP4R3_XENLA PP4R3_XENLA LVLMSSMHSFLGLC---------------------------ALRFMRKIVGLKDEFYNRY A8SMA7_BOVIN A8SMA7_BOVIN LVLMASKHAFLALC---------------------------ALRFKRKIIGLKDEFYNRY P4R3A_MOUSE P4R3A_MOUSE LVLMASKHAFLALC---------------------------ALRFKRKIIGLKDEFYNRY P4R3A_HUMAN P4R3A_HUMAN LVLMASKHAFLALC---------------------------ALRFKRKIIGLKDEFYNRY Q71SA2_BOVIN Q71SA2_BOVIN LVLMASKHAFLALC---------------------------ALRFKRKIIGLKDEFYNRY Q6P100_DANRE Q6P100_DANRE LTLMNSKHTFLALC---------------------------ALRFMRRIIGLKDEYYNRY Q4SQL5_TETNG Q4SQL5_TETNG LVLMNSKHTFLALCKSCTQADTLRGIFTTHRNGPLFVCFQGALRFMRRIIGLKDEYYNRY P4R3A_XENLA P4R3A_XENLA LILMNSKHTFLALC---------------------------ALRFMRRIIGLKDEFYNRY PP4R3_XENTR PP4R3_XENTR LILMNSKHTFLALC---------------------------ALRFMRRIIGLKDEFYNRY P4R3B_XENLA P4R3B_XENLA LILMNSKHTFLALC---------------------------ALRFMRRIIGLKDEFYNRY B4DKA9_HUMAN B4DKA9_HUMAN LVLMNSKHTFLALC---------------------------ALRFMRRIIGLKDEFYNRY P4R3B_HUMAN P4R3B_HUMAN LVLMNSKHTFLALC---------------------------ALRFMRRIIGLKDEFYNRY P4R3B_MOUSE P4R3B_MOUSE LVLMNSKHTFLALC---------------------------ALRFMRRIIGLKDEFYNRY Q3V166_MOUSE Q3V166_MOUSE LVLMNSKHTFLALC---------------------------ALRFMRRIIGLKDEFYNRY MATCH * * * *:.* ** .:** *::: *:*: ** * CONSENSUS L?LM?SKH?FL?LC???????????????????????????ALRFMR?IIGLKDE?YNRY

A2ADI4_MOUSE A2ADI4_MOUSE IIKENLFEPVVNAFMHNGHRYNMLNSAIIELFEFIRQ----------------------- B2RX57_MOUSE B2RX57_MOUSE IIKKNLFEPVVNAFMHNGHRYNMLNSAIIELFEFIRK----------------------- SMEK3_MOUSE SMEK3_MOUSE IIKKNLFEPVVNAFMHNGHRYNMLNSAIIELFEFIRK----------------------- SMEK3_HUMAN SMEK3_HUMAN IIKGNLFEPVVNALLDNGTRYNMLNSAILELFEYIRV----------------------- PP4R3_DANRE PP4R3_DANRE IMRNFLFEPVVKAFLNNGSRYNLINSAIIEMFEYVRV----------------------- PP4R3_TETNG PP4R3_TETNG IMRNFLFEPVIKAFLNNGSRYNLMNSAIIEMFEYVRV----------------------- PP4R3_XENLA PP4R3_XENLA IVKSFLFEPVVKAFLNNGSRYNLMNSAILEIFEYIRV----------------------- A8SMA7_BOVIN A8SMA7_BOVIN IMKK-------------------------------------------------------- P4R3A_MOUSE P4R3A_MOUSE IMKSFLFEPVVKAFLNNGSRYNLMNSAIIEMFEFIRV----------------------- P4R3A_HUMAN P4R3A_HUMAN IMKSFLFEPVVKAFLNNGSRYNLMNSAIIEMFEFIRV----------------------- Q71SA2_BOVIN Q71SA2_BOVIN IMKSFLFEPVVKAFLNNGSRYNLMNSAIIEMFEFIRV----------------------- Q6P100_DANRE Q6P100_DANRE IMKGNLFEPVINALLDNGTRYNLLNSAIIELFDFIRV----------------------- Q4SQL5_TETNG Q4SQL5_TETNG IIKGNLFEPVINALLDNGTRYNLLNSAIIELFEFIKVVRRPTNVSEIFHIWTLAWSNVAP P4R3A_XENLA P4R3A_XENLA IIKGNLFDPVINALLDNGTRYNLLNSAIIELFEFIRV----------------------- PP4R3_XENTR PP4R3_XENTR IIKGNLFEPVINALLDNGTRYNLLNSAIIELFEFIRV----------------------- P4R3B_XENLA P4R3B_XENLA IIKGNLFEPVIHALLDNGTRYNLLNSAIIELFEFIRV----------------------- B4DKA9_HUMAN B4DKA9_HUMAN ITKGNLFEPVINALLDNGTRYNLLNSAVIELFEFIRV----------------------- P4R3B_HUMAN P4R3B_HUMAN ITKGNLFEPVINALLDNGTRYNLLNSAVIELFEFIRV----------------------- P4R3B_MOUSE P4R3B_MOUSE ITKGNLFEPVINALLDNGTRYNLLNSAVIELFEFIRV----------------------- Q3V166_MOUSE Q3V166_MOUSE ITKGNLFEPVINALLDNGTRYNLLNSAVIELFEFIRV----------------------- MATCH * : CONSENSUS I?K??LFEPV??A?L?NG?RYN??NSA?IE?FE?IRV???????????????????????

A2ADI4_MOUSE A2ADI4_MOUSE ----ENIKSLIANIVENFFISFESIEYVQTFKGLKIKYEEEKNE--CQVRRNLLNVVCQK B2RX57_MOUSE B2RX57_MOUSE ----ENITSLIVNIVENFFRAFKSIEYVQTFKGLKTKYEEEKKRK-SQRRKNLHSIMHPK SMEK3_MOUSE SMEK3_MOUSE ----ENITSLIVNIVENFFRAFKSIEYVQTFKGLKTKYEEEKKRK-SQRRKNLHSIMHPK SMEK3_HUMAN SMEK3_HUMAN ----ENIKPLVSHIVEKFYNTLESIEYVQTFKGLKIKYEKERDRQ-SQIQKNLHSVLQNI PP4R3_DANRE PP4R3_DANRE ----EDVKSLTAHIIENYWKGLEDVDYVQTFKGLKLRYEQQRERQDNPKLDSMRSILRNH PP4R3_TETNG PP4R3_TETNG ----EDVKSLTAHIVENYWKALEDVDYVQTFKGLKLRYEQQRERQDNPKLDSMRSILRNH PP4R3_XENLA PP4R3_XENLA ----EDIKSLTAHVVENYWKALEDVEYVQTFKGLKLRYDQQRERQDNPKLDSMRSILRNH A8SMA7_BOVIN A8SMA7_BOVIN -------------------------------KKKKKKKKKKKKKK--------------K P4R3A_MOUSE P4R3A_MOUSE ----EDIKSLTAHVIENYWKALEDVDYVQTFKGLKLRFEQQRERQDNPKLDSMRSILRNH P4R3A_HUMAN P4R3A_HUMAN ----EDIKSLTAHVIENYWKALEDVDYVQTFKGLKLRFEQQRERQDNPKLDSMRSILRNH Q71SA2_BOVIN Q71SA2_BOVIN ----EDIKSLTAHVVENYWKALEDVDYVQTFKGLKLRFEQQRERQDNPKLDSMRSILRNH Q6P100_DANRE Q6P100_DANRE ----EDIRSLTAHIVENFQSALQSIQYVQTFKGLKGRYEQEQERQ-SRGL---------S Q4SQL5_TETNG Q4SQL5_TETNG CLFQEDIKSLIAHIVDNFYKALEPIEYVQTFKGLKGRYEQEKDRQ-SQRISS-------- P4R3A_XENLA P4R3A_XENLA ----EDIKSLTSHIVENFYKALEPIEYVQTFKGLKTRYEQEKDRQ-SQKLSSVPSILRSN PP4R3_XENTR PP4R3_XENTR ----EDIKSLTSHIVENFYKALESIEYVQTFKGLKTRYEQEKDRQ-SQKLSSVPSILRSN P4R3B_XENLA P4R3B_XENLA ----EDIKSLTSHIVENFYKALESIEYVQTFKGLKTRYEQEKDRQ-SQKLSSVPSILRSN B4DKA9_HUMAN B4DKA9_HUMAN ----EDIKSLTAHIVENFYKALESIEYVQTFKGLKTKYEQEKDRQ-NQKLNSVPSILRSN P4R3B_HUMAN P4R3B_HUMAN ----EDIKSLTAHIVENFYKALESIEYVQTFKGLKTKYEQEKDRQ-NQKLNSVPSILRSN P4R3B_MOUSE P4R3B_MOUSE ----EDIKSLTAHIVENFYKALESIEYVQTFKGLKTKYEQEKDRQ-NQKLNSVPSILRSN Q3V166_MOUSE Q3V166_MOUSE ----EDIKSLTAHIVENFYKALESIEYVQTFKGLKTKYEQEKDRQ-NQKLNSVPSILRSN MATCH * * : .:::.. CONSENSUS ????E?IKSL??H?VEN???ALE???YVQTFKGLK??YE????RQ?????????S?????

A2ADI4_MOUSE A2ADI4_MOUSE IYCICTNDMGLKVKSDICHRRI---------------------TET--KEAILPNR---- B2RX57_MOUSE B2RX57_MOUSE MYYRHIEDMEVKVKADICCRGI---------------IEEEERQGGGEEGAILPMG---- SMEK3_MOUSE SMEK3_MOUSE MYYRHIEDMEVKVKADICCRGI---------------IEEEERQGGGEEGAILPMG---- SMEK3_HUMAN SMEK3_HUMAN VVFR-GTIEEIGLEEEICFMEDAGEAVMPPLEDDDEFMETKRTQEG--EAVMPPLEDDDK PP4R3_DANRE PP4R3_DANRE RFRR--DARTLEDEEEMWFNTD-----------------EEDLEDG--EAVVPPSD---- PP4R3_TETNG PP4R3_TETNG RFRR--DARTLEDEEEMWFNTD-----------------EDDLEDG--ETVVRTSD---- PP4R3_XENLA PP4R3_XENLA RYRR--DARSIEDEEEMWFNTD-----------------EDDLEDG--EPVVLPSE---- A8SMA7_BOVIN A8SMA7_BOVIN KKKK-------------------------------------------------------- P4R3A_MOUSE P4R3A_MOUSE RYRR--DARTLEDEEEMWFNTD-----------------EDDMEDG--EAVVSPSD---- P4R3A_HUMAN P4R3A_HUMAN RYRR--DARTLEDEEEMWFNTD-----------------EDDMEDG--EAVVSPSD---- Q71SA2_BOVIN Q71SA2_BOVIN R----------------------------------------------------------- Q6P100_DANRE Q6P100_DANRE RFRR--DARSFPEDEELWKEEE-----------------E---DEE--EPADTETQ---- Q4SQL5_TETNG Q4SQL5_TETNG RYRR--DARSLDEDEELCHSKQ-------------------------------------- P4R3A_XENLA P4R3A_XENLA RFRR--DARALEDDEELWFNED-----------------DE--EEG--EAVVPPVE---- PP4R3_XENTR PP4R3_XENTR RFRR--DARALEDDEELWFNED-----------------EE--EEG--EAVVPPVE---- P4R3B_XENLA P4R3B_XENLA RFRR--DARALEDDEELWFNED-----------------DE--EEG--EAVVPPVE---- B4DKA9_HUMAN B4DKA9_HUMAN RFRR--DAKALEEDEEMWFNED-----------------EE--EEG--KAVVAPVE---- P4R3B_HUMAN P4R3B_HUMAN RFRR--DAKALEEDEEMWFNED-----------------EE--EEG--KAVVAPVE---- P4R3B_MOUSE P4R3B_MOUSE RFRR--DAKALEEDEEMWFNED-----------------DD--EEG--KAVITPVE---- Q3V166_MOUSE Q3V166_MOUSE RFRR--DAKALEEDEEMWFNED-----------------DD--EEG--KAVITPVE---- MATCH CONSENSUS ???R????????????????????????????????????????????????????????

A2ADI4_MOUSE A2ADI4_MOUSE -------------------RDFPSHYGIIMKIEETNESESAIEGQ-KIKSSEA----FER B2RX57_MOUSE B2RX57_MOUSE -------------------SDFTNNYDIFMKNKDTNESESAIEGQ-KIKSSEA----SEC SMEK3_MOUSE SMEK3_MOUSE -------------------SDFTNNYDIFMKNKDTNESESAIEGQ-KIKSSEA----SEC SMEK3_HUMAN SMEK3_HUMAN FTETKRTHQEGEAVMPPLEDD-----DEFMETKRNQEHEGKVDSP-KRTSSGD----FKF PP4R3_DANRE PP4R3_DANRE --------------KMKNDEDLMDPISKFMERKKLKDSEEKEVLTGKASLSGRQSPSFKL PP4R3_TETNG PP4R3_TETNG --------------KIKTEEDLMEPISKFMERKKLKEPEDKEILA-KSSFSGRQNPSFKL PP4R3_XENLA PP4R3_XENLA --------------KIKNSEDLMDPISKFMERKKLKESEEKEVLL-KTNLTGRQSPNFKL A8SMA7_BOVIN A8SMA7_BOVIN ------------------------------KKKKKKKKKKK------------------- P4R3A_MOUSE P4R3A_MOUSE --------------KTKNDDDIMDPISKFMERKKLKESEEKEVLL-KTNLSGRQSPSFKL P4R3A_HUMAN P4R3A_HUMAN --------------KTKNDDDIMDPISKFMERKKLKESEEKEVLL-KTNLSGRQSPSFKL Q71SA2_BOVIN Q71SA2_BOVIN ------------------------------------------------------------ Q6P100_DANRE Q6P100_DANRE --------------HCK------SDYGRFMESEKAKENQEKENQA-KRSSSGS----FKF Q4SQL5_TETNG Q4SQL5_TETNG ------------------------QLGVFCQD---------------------------- P4R3A_XENLA P4R3A_XENLA --------------KTKPEDDFPEGYEKFLETKKAKELEDKENLP-KRTSVGA----FKF PP4R3_XENTR PP4R3_XENTR --------------KTKTEDDFPEGYEKFLETKKAKELEDKENLP-KRTSVGG----FKF P4R3B_XENLA P4R3B_XENLA --------------KTKPEDDFPEGYEKFLETKKAKELEDKENLP-KRTSVGG----FKF B4DKA9_HUMAN B4DKA9_HUMAN --------------KPKPEDDFPDNYEKFMETKKAKESEDKENLP-KRTSPGG----FKF P4R3B_HUMAN P4R3B_HUMAN --------------KPKPEDDFPDNYEKFMETKKAKESEDKENLP-KRTSPGG----FKF P4R3B_MOUSE P4R3B_MOUSE --------------KSKTEDDFPDSYEKFMETKKAKESEDKENLP-KRASSGG----FKF Q3V166_MOUSE Q3V166_MOUSE --------------KSKTEDDFPDSYEKFMETKKAKESEDKENLP-KRASSGG----FKF MATCH CONSENSUS ????????????????????D???????F???K???E?E???????K?????????????

A2ADI4_MOUSE A2ADI4_MOUSE CPSHGDASATRMSRSHCSS----------------------------------LVPLVNY B2RX57_MOUSE B2RX57_MOUSE CPSHGDASATRMSRSHCSS----------------------------------LVPLVDY SMEK3_MOUSE SMEK3_MOUSE CPSHGDASATRMSRSHCSS----------------------------------LVPLVDY SMEK3_HUMAN SMEK3_HUMAN SSSYSACAAIGTGSPSGSS----------------------------------VVRLVDH PP4R3_DANRE PP4R3_DANRE SFSSSPKASLSSPPTASLH------PGSPGSPSSPGTGARSSPPSAAVTTKGGLVGLVDY PP4R3_TETNG PP4R3_TETNG AFSGSTKTSLSSPPPSASL-----SPGSPGSPGSPGSGARSSPSNTSVTTKGGLVGLVDY PP4R3_XENLA PP4R3_XENLA SFSGATKTNLTSQLSASGHPGSPGSPGSPGSPESPGSVSKSTPQAAAITTKGGLIGLVDY A8SMA7_BOVIN A8SMA7_BOVIN ------------------------------------------------------------ P4R3A_MOUSE P4R3A_MOUSE SLSSGTKTNLTSQSSATSLPGSPGSPGSPGSPGSPGSVPKSTSQTAAITTKGGLVGLVDY P4R3A_HUMAN P4R3A_HUMAN SLSSGTKTNLTSQSSTTNLPGSPGSPGSPGSPGSPGSVPKNTSQTAAITTKGGLVGLVDY Q71SA2_BOVIN Q71SA2_BOVIN ------------------------------------------------------------ Q6P100_DANRE Q6P100_DANRE TFSHSAASANSAKATSASS---------------------------SGASTAARTALVDY Q4SQL5_TETNG Q4SQL5_TETNG SFSPRHTSDEGKTRGSCTH----------------------------------------- P4R3A_XENLA P4R3A_XENLA TFSHSVSAANGANSTNSKS----VAAHTPPATSNGSSSKNTSLTTTVASTKGSLIGLVDY PP4R3_XENTR PP4R3_XENTR TFSHSVSAANGANSTNSKS----VAAHTPPASSNGSSSKNTSLTTTVASAKGSLIGLVDY P4R3B_XENLA P4R3B_XENLA TFSHSVSAANGANSTNSKS----VAAHTPPATSNGSSSKNTSLTTTVASTKGSLIGLVDY B4DKA9_HUMAN B4DKA9_HUMAN TFSHSASAANGTNSKSVVA-------QIPPATSNGSSSKTTNLPTSVTATKGSLVGLVDY P4R3B_HUMAN P4R3B_HUMAN TFSHSASAANGTNSKSVVA-------QIPPATSNGSSSKTTNLPTSVTATKGSLVGLVDY P4R3B_MOUSE P4R3B_MOUSE TFSHSPSATNGTNSTNSKS----VVSQTTPASSNVASSKTTSLATSVTATKGNLVGLVDY Q3V166_MOUSE Q3V166_MOUSE TFSHSPSATNGTNSTNSKS----VVSQTTPASSNVASSKTTSLATSVTATK---VCKIKI MATCH CONSENSUS ??S?????????????????????????????????????????????????????LV??

A2ADI4_MOUSE A2ADI4_MOUSE PYDTDDENGDDPYGND------NDEDEEPPQKRPNLSS B2RX57_MOUSE B2RX57_MOUSE LYDTDDENDDDPYGNDKHEDEHEDEDEEPPPKRPNLST SMEK3_MOUSE SMEK3_MOUSE LYDTDDENDDDPYGNDKHEDEHEDEDEEPPPKRPNLST SMEK3_HUMAN SMEK3_HUMAN PDDEEEKEEDEEEKEE------DKEDETSPKKKPHLSS PP4R3_DANRE PP4R3_DANRE PDDDEEDEDEE--------DADSKEESPPLSKKSKLSS PP4R3_TETNG PP4R3_TETNG PDDDEEEEDDDDEESK--------EEPLPPSKKSRLSS PP4R3_XENLA PP4R3_XENLA PDDDEEDDDND---------EEEKEERLPLTKKARLGS A8SMA7_BOVIN A8SMA7_BOVIN -------------------------------------- P4R3A_MOUSE P4R3A_MOUSE PDDDEDDDEDE-----------DKEDTLPVSKKAKFES P4R3A_HUMAN P4R3A_HUMAN PDDDEDDDEDE-----------DKEDTLPLSKKAKFDS Q71SA2_BOVIN Q71SA2_BOVIN -------------------------------------- Q6P100_DANRE Q6P100_DANRE PDDEDEDEDDD-------------EDQQAPHKRPRLGS Q4SQL5_TETNG Q4SQL5_TETNG ----HTVAETE--------------------------- P4R3A_XENLA P4R3A_XENLA PDDEDEEEEED----------------ASPRKRPRLGS PP4R3_XENTR PP4R3_XENTR PDDEDEEEEED----------------TSPRKRPRLGS P4R3B_XENLA P4R3B_XENLA PDDEDEEEEED----------------TSPRKRPRLGS B4DKA9_HUMAN B4DKA9_HUMAN PDDEEEDEEEE----------------SSPRKRPRLGS P4R3B_HUMAN P4R3B_HUMAN PDDEEEDEEEE----------------SSPRKRPRLGS P4R3B_MOUSE P4R3B_MOUSE PDDEEEDEEEE----------------SSPRKRPRLGS Q3V166_MOUSE Q3V166_MOUSE PY------------------------------------ MATCH CONSENSUS ??D????????????????????????????K??????


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