Alignment of the gene Family HBG057591 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
A1L1D3_XENTR A1L1D3_XENTR DEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRAPLQLR Q5ZLV6_CHICK Q5ZLV6_CHICK DEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRAPLQLR Q5SX31_MOUSE Q5SX31_MOUSE DEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRAPLQLR TRI37_MOUSE TRI37_MOUSE DEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRAPLQLR B5DF77_RAT B5DF77_RAT DEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRAPLQLR A8WFQ1_BOVIN A8WFQ1_BOVIN DEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRAPLQLR Q95LW3_MACFA Q95LW3_MACFA DEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRAPLQLR Q5RE26_PONAB Q5RE26_PONAB DEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRAPLQLR A8MTM4_HUMAN A8MTM4_HUMAN DQPKINSIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRAPLQLR B4DGZ3_HUMAN B4DGZ3_HUMAN DEQSVE----------------------------------RWLTEQRAQCPHCRAPLQLR A8K0V9_HUMAN A8K0V9_HUMAN DEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRAPLQLR TRI37_HUMAN TRI37_HUMAN DEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRAPLQLR A8K8U4_HUMAN A8K8U4_HUMAN DEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRAPLQLR MATCH *: .:: ******************** CONSENSUS DEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRAPLQLR

A1L1D3_XENTR A1L1D3_XENTR ELVNCRWAEEVTQQLDTLQLCSLNKHEENEKDKCENHHEKLSVFCWTCKICICHQCALWG Q5ZLV6_CHICK Q5ZLV6_CHICK ELVNCRWAEEVTQQLDTLQLCNLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALWG Q5SX31_MOUSE Q5SX31_MOUSE ELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALWG TRI37_MOUSE TRI37_MOUSE ELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALWG B5DF77_RAT B5DF77_RAT ELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALWG A8WFQ1_BOVIN A8WFQ1_BOVIN ELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALWG Q95LW3_MACFA Q95LW3_MACFA ELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHH---------------------- Q5RE26_PONAB Q5RE26_PONAB ELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALWG A8MTM4_HUMAN A8MTM4_HUMAN ELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALWG B4DGZ3_HUMAN B4DGZ3_HUMAN ELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALWG A8K0V9_HUMAN A8K0V9_HUMAN ELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALWG TRI37_HUMAN TRI37_HUMAN ELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALWG A8K8U4_HUMAN A8K8U4_HUMAN ELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALWG MATCH *********************.*.************** CONSENSUS ELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALWG

A1L1D3_XENTR A1L1D3_XENTR GMHGGHTFKPLAEIYEQHVTKVNEEVAKLRRRLMELISLVQEVERNVEAVRGAKDERVRE Q5ZLV6_CHICK Q5ZLV6_CHICK GMHGGHTFKPLAEIYEQHVTKVNEEVAKLRRRLMELISLVQEVERNVEAVRSAKDERVRE Q5SX31_MOUSE Q5SX31_MOUSE GMHGGHTFKPLAEIYEQHVTKVNEEVAKLRRRLMELISLVQEVERNVEAVRNAKDERVRE TRI37_MOUSE TRI37_MOUSE GMHGGHTFKPLAEIYEQHVTKVNEEVAKLRRRLMELISLVQEVERNVEAVRNAKDERVRE B5DF77_RAT B5DF77_RAT GMHGGHTFKPLAEIYEQHVTKVNEEVAKLRRRLMELISLVQEVERNVEAVRNAKDERVRE A8WFQ1_BOVIN A8WFQ1_BOVIN GMHSGHTFKPLAEIYEQHVTKVNEEVAKLRRRLMELISLVQEVERNVEAVRNAKDERVRE Q95LW3_MACFA Q95LW3_MACFA ------------------------------------------------------------ Q5RE26_PONAB Q5RE26_PONAB GMHGGHTFKPLAEIYEQHVTKVNEEVAKLRRRLMELISLVQEVERNVEAVRNAKDERVRE A8MTM4_HUMAN A8MTM4_HUMAN GMHGGHTFKPLAEIYEQHVTKVNEEVAKLRRRLMELISLVQEVERNVEAVRNAKDERVRE B4DGZ3_HUMAN B4DGZ3_HUMAN GMHGGHTFKPLAEIYEQHVTKVNEEVAKLRRRLMELISLVQEVERNVEAVRNAKDERVRE A8K0V9_HUMAN A8K0V9_HUMAN GMHGGHTFKPLAEIYEQHVTKVNEEVAKLRRRLMELISLVQEVERNVEAVRNAKDERVRE TRI37_HUMAN TRI37_HUMAN GMHGGHTFKPLAEIYEQHVTKVNEEVAKLRRRLMELISLVQEVERNVEAVRNAKDERVRE A8K8U4_HUMAN A8K8U4_HUMAN GMHGGHTFKPLAEIYEQHVTKVNEEVAKLRRRLMELISLVQEVERNVEAVRNAKDERVRE MATCH CONSENSUS GMHGGHTFKPLAEIYEQHVTKVNEEVAKLRRRLMELISLVQEVERNVEAVR?AKDERVRE

A1L1D3_XENTR A1L1D3_XENTR IRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRSCSKSELISKS Q5ZLV6_CHICK Q5ZLV6_CHICK IRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRSCSKSELISKS Q5SX31_MOUSE Q5SX31_MOUSE IRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRSCSKSELISKS TRI37_MOUSE TRI37_MOUSE IRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRSCSKSELISKS B5DF77_RAT B5DF77_RAT IRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRSCSKSELISKS A8WFQ1_BOVIN A8WFQ1_BOVIN IRNVVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLVQEVEHQLRSCSKSELISKS Q95LW3_MACFA Q95LW3_MACFA ------------------------------------------------------------ Q5RE26_PONAB Q5RE26_PONAB IRNAVEMMIARFDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRSCSKSELISKS A8MTM4_HUMAN A8MTM4_HUMAN IRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRSCSKSELISKS B4DGZ3_HUMAN B4DGZ3_HUMAN IRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRSCSKSELISKS A8K0V9_HUMAN A8K0V9_HUMAN IRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRSCSKSELISKS TRI37_HUMAN TRI37_HUMAN IRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRSCSKSELISKS A8K8U4_HUMAN A8K8U4_HUMAN IRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRSCSKSELISKS MATCH CONSENSUS IRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRSCSKSELISKS

A1L1D3_XENTR A1L1D3_XENTR PEILMMFQQVHRKPMASFVTTPVPPDFTREDFVGIQLQAFDNIEASELVPAYDSATFVLE Q5ZLV6_CHICK Q5ZLV6_CHICK SEILMMFQQVHRKPMASFVTTPVPPDFT-----------------SELVPAYDSTTFVLE Q5SX31_MOUSE Q5SX31_MOUSE SEILMMFQQVHRKPMASFVTTPVPPDFT-----------------SELVPSYDSATFVLE TRI37_MOUSE TRI37_MOUSE SEILMMFQQVHRKPMASFVTTPVPPDFT-----------------SELVPSYDSATFVLE B5DF77_RAT B5DF77_RAT AEILMMFQQVHRKPMASFVTTPVPPDFT-----------------SELVPSYDSATFVLE A8WFQ1_BOVIN A8WFQ1_BOVIN SEILMMFQQVHRKPMASFVTTPVPPDFT-----------------SELVPSYDSATFVLE Q95LW3_MACFA Q95LW3_MACFA ------------------------------------------------------------ Q5RE26_PONAB Q5RE26_PONAB SEILMMFQQVHRKPMASFVTTPVPPDFT-----------------SELVPSYDSATFVLE A8MTM4_HUMAN A8MTM4_HUMAN SEILMMFQQVHRKPMASFVTTPVPPDFT-----------------SELVPSYDSATFVLE B4DGZ3_HUMAN B4DGZ3_HUMAN SEILMMFQQVHRKPMASFVTTPVPPDFT-----------------SELVPSYDSATFVLE A8K0V9_HUMAN A8K0V9_HUMAN SEILMMFQQVHRKPMASFVTTPVPPDFT-----------------SELVPSYDSATFVLE TRI37_HUMAN TRI37_HUMAN SEILMMFQQVHRKPMASFVTTPVPPDFT-----------------SELVPSYDSATFVLE A8K8U4_HUMAN A8K8U4_HUMAN SEILMMFQQVHRKPMASFVTTPVPPDFT-----------------SELVPSYDSATFVLE MATCH CONSENSUS ?EILMMFQQVHRKPMASFVTTPVPPDFT?????????????????SELVP?YDSATFVLE

A1L1D3_XENTR A1L1D3_XENTR NFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAGLPETSKYEYR Q5ZLV6_CHICK Q5ZLV6_CHICK NFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAGLPETSKYEYR Q5SX31_MOUSE Q5SX31_MOUSE NFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAGLPETSKYEYR TRI37_MOUSE TRI37_MOUSE NFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAGLPETSKYEYR B5DF77_RAT B5DF77_RAT NFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAGLPETSKYEYR A8WFQ1_BOVIN A8WFQ1_BOVIN NFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAGLPETSKYEYR Q95LW3_MACFA Q95LW3_MACFA ---------------------------------------------------------EYR Q5RE26_PONAB Q5RE26_PONAB NFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAGLPETSKYEYR A8MTM4_HUMAN A8MTM4_HUMAN NFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAGLPETSKYEYR B4DGZ3_HUMAN B4DGZ3_HUMAN NFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAGLPETSKYEYR A8K0V9_HUMAN A8K0V9_HUMAN NFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAGLPETSKYEYR TRI37_HUMAN TRI37_HUMAN NFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAGLPETSKYEYR A8K8U4_HUMAN A8K8U4_HUMAN NFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAGLPETSKYEYR MATCH *** CONSENSUS NFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAGLPETSKYEYR

A1L1D3_XENTR A1L1D3_XENTR VEMVHQSSNDPAKNIIREFASDFEVGECWGYNRFFRLDLLANEGYLNRTNDTVILRFQVR Q5ZLV6_CHICK Q5ZLV6_CHICK VEMVHQSTNDPTKNIIREFASDFEVGECWGYNRFFRLDLLANEGYLNRQNDTVILRFQVR Q5SX31_MOUSE Q5SX31_MOUSE VEMVHQSCNDPTKNIIREFASDFEVGECWGYNRFFRLDLLANEGYLNRQNDTVILRFQVR TRI37_MOUSE TRI37_MOUSE VEMVHQSCNDPTKNIIREFASDFEVGECWGYNRFFRLDLLANEGYLNRQNDTVILRFQVR B5DF77_RAT B5DF77_RAT VEMVHQSCNDPTKNIIREFASDFEVGECWGYNRFFRLDLLANEGYLNRQNDTVILRFQVR A8WFQ1_BOVIN A8WFQ1_BOVIN VEMVHQSCNDPTKNIIREFASDFEVGECWGYNRFFRLDLLANEGYLNRQNDTVILRFQVR Q95LW3_MACFA Q95LW3_MACFA VEMVHQSCNDPTKNIIREFASDFEVGECWGYNRFFRLDLLANEGYLNPQNDTVILRFQVR Q5RE26_PONAB Q5RE26_PONAB VEMVHQSCNDPTKNIIREFASDFEVGECWGYNRFFRLDLLANEGYLNPQNDTVILRFQVR A8MTM4_HUMAN A8MTM4_HUMAN VEMVHQSCNDPTKNIIREFASDFEVGECWGYNRFFRLDLLANEGYLNPQNDTVILRFQVR B4DGZ3_HUMAN B4DGZ3_HUMAN VEMVHQSCNDPTKNIIREFASDFEVGECWGYNRFFRLDLLANEGYLNPQNDTVILRFQVR A8K0V9_HUMAN A8K0V9_HUMAN VEMVHQSCNDPTKNIIREFASDFEVGECWGYNRFFRLDLLANEGYLNPQNDTVILRFQVR TRI37_HUMAN TRI37_HUMAN VEMVHQSCNDPTKNIIREFASDFEVGECWGYNRFFRLDLLANEGYLNPQNDTVILRFQVR A8K8U4_HUMAN A8K8U4_HUMAN VEMVHQSCNDPTKNIIREFASDFEVGECWGYNRFFRLDLLANEGYLNPQNDTVILRFQVR MATCH ******* ***:*********************************** *********** CONSENSUS VEMVHQSCNDPTKNIIREFASDFEVGECWGYNRFFRLDLLANEGYLN?QNDTVILRFQVR

A1L1D3_XENTR A1L1D3_XENTR SPTFFQKCRDQHWYISQLEAAQTSYIQQINNLKERLTIELSRNQKSRGMSPPDTHLSPQN Q5ZLV6_CHICK Q5ZLV6_CHICK SPTFFQKCRDQHWYIAQLEAAQTSYIQQINNLKERLAIELSRTQKSRGISPPDTHLSPQN Q5SX31_MOUSE Q5SX31_MOUSE SPTFFQKCRDQHWYITQLEAAQTGYIQQINNLKERLTIELSRTQKSRDLSPPDNHLSPQN TRI37_MOUSE TRI37_MOUSE SPTFFQKCRDQHWYITQLEAAQTGYIQQINNLKERLTIELSRTQKSRDLSPPDNHLSPQN B5DF77_RAT B5DF77_RAT SPTFFQKCRDQHWYITQLEAAQTGYIQQINNLKERLTIELSRTQKSRDLSPPDNHLSPQN A8WFQ1_BOVIN A8WFQ1_BOVIN SPTFFQKCRDQHWYITQLEAAQTSYIQQINNLKERLTIELSRTQKSRDLSPPDNHLSPQN Q95LW3_MACFA Q95LW3_MACFA SPTFFQKSRDQHWYITQLEAAQTSYIQQINNLKERLTIELSRTQKSRDLSPPDNHLSPQN Q5RE26_PONAB Q5RE26_PONAB SPTFFQKSRDQHWYITQLEAAQTSYIQQINNLKERLTIELSRTQKSRDLSPPDNHLSPQN A8MTM4_HUMAN A8MTM4_HUMAN SPTFFQKSRDQHWYITQLEAAQTSYIQQINNLKERLTIELSRTQKSRDLSPPDNHLSPQN B4DGZ3_HUMAN B4DGZ3_HUMAN SPTFFQKSRDQHWYITQLEAAQTSYIQQINNLKERLTIELSRTQKSRDLSPPDNHLSPQN A8K0V9_HUMAN A8K0V9_HUMAN SPTFFQKSRDQHWYITQLEAAQTSYIQQINNLKERLTIELSRTQKSRDLSPPDNHLSPQN TRI37_HUMAN TRI37_HUMAN SPTFFQKSRDQHWYITQLEAAQTSYIQQINNLKERLTIELSRTQKSRDLSPPDNHLSPQN A8K8U4_HUMAN A8K8U4_HUMAN SPTFFQKSRDQHWYITQLEAAQTSYIQQINNLKERLTIELSRTQKSRDLSPPDNHLSPQN MATCH *******.*******:*******.************:*****.****.:****.****** CONSENSUS SPTFFQK?RDQHWYITQLEAAQT?YIQQINNLKERLTIELSRTQKSRDLSPPDNHLSPQN

A1L1D3_XENTR A1L1D3_XENTR DESPEARSKKT----DVNLESISSLPAPREAEEDEDKSLSVFNQ---QDLSDGDLDVDLA Q5ZLV6_CHICK Q5ZLV6_CHICK DDGPETRSKKSGPSTEALLESVAAPGLVRDNK--EEDEEKIQHEDFNHELSDGDLDVDLA Q5SX31_MOUSE Q5SX31_MOUSE DDSPETRTKKAGSCSDMLLEGGPTCASVRETKEDEDEEEKIQNEDYHHELSDGDLDLDLV TRI37_MOUSE TRI37_MOUSE DDSPETRTKKAGSCSDMLLEGGPTCASVRETKEDEDEEEKIQNEDYHHELSDGDLDLDLV B5DF77_RAT B5DF77_RAT DDTPETRAKKAGSCSDMLLEGGPTSASVRETKEDEDEEEKIQNEDYHHELSDGDLDLDLV A8WFQ1_BOVIN A8WFQ1_BOVIN DDTPETRAKKSGSCADVLLQDGPTTASVREVKEDEEDEEKIQNEDYHHELSDGDLDLDLV Q95LW3_MACFA Q95LW3_MACFA DDVPETRAKKS-ACSDMLLEGGPTTASIREAKEDEEEEEKIQNEDYHHELSDGDLDLDLV Q5RE26_PONAB Q5RE26_PONAB DDAPETRAKKS-ACSDMLLEGGPTTASVREAKEDEEDEEKIQNEDYHHELSDGDLDLDLV A8MTM4_HUMAN A8MTM4_HUMAN DDALETRAKKS-ACSDMLLEGGPTTASVREAKEDEEDEEKIQNEDYHHELSDGDLDLDLV B4DGZ3_HUMAN B4DGZ3_HUMAN DDALETRAKKS-ACSDMLLEGGPTTASVREAKEDEEDEEKIQNEDYHHELSDGDLDLDLV A8K0V9_HUMAN A8K0V9_HUMAN DDALETRAKKS-ACSDMLLEGGPTTASVREAKEDEEDEEKIQNEDYHHELSDGDLDLDLV TRI37_HUMAN TRI37_HUMAN DDALETRAKKS-ACSDMLLEGGPTTASVREAKEDEEDEEKIQNEDYHHELSDGDLDLDLV A8K8U4_HUMAN A8K8U4_HUMAN DDALETRAKKS-ACSDMLLEGGPTTASVREAKEDEEDEEKIQNEDYHHELSDGDLDLDLV MATCH *: *:*:**: : *:. .: *: : *:.. .: :: ::*******:**. CONSENSUS DD??ETR?KK???C?D?LLE?GPT?ASVRE?KEDE??EEKIQNEDYHHELSDGDLDLDLV

A1L1D3_XENTR A1L1D3_XENTR GEDEANHLEGSCSSASSTATSITEENDIDEETMSGENDVEYSGNMDLEEGELMEDPSTA- Q5ZLV6_CHICK Q5ZLV6_CHICK GEDEVNHLDGSSSSASSTATSNTEENDIDEETMSGENDVEYSNNMELEEGDLMEDAAAAA Q5SX31_MOUSE Q5SX31_MOUSE GEDEVNHLDGSSSSASSTATSNTEENDIDEETMSGENDVEYN-SMELEEGELMEDAAAA- TRI37_MOUSE TRI37_MOUSE GEDEVNHLDGSSSSASSTATSNTEENDIDEETMSGENDVEYN-SMELEEGELMEDAAAA- B5DF77_RAT B5DF77_RAT GEDEVNHLDGSSSSASSTATSNTEENDIDEETMSGENDVEYN-SMELEEGELMEDAAAA- A8WFQ1_BOVIN A8WFQ1_BOVIN GEDEANQLDGSSSSASSTATSNTEENDIDEETMSGENDVEYN-NMELEEGELMEDAAAA- Q95LW3_MACFA Q95LW3_MACFA YEDEVNQLDGSSSSASSTATSNTEENDIDEETMSGENDVEYN-NMELEEGELMED-AAA- Q5RE26_PONAB Q5RE26_PONAB YEDEVNQLDGSSSSASSTATSNTEENDIDEETMSGENDVEYN-NMELEEGELMEDAAAA- A8MTM4_HUMAN A8MTM4_HUMAN YEDEVNQLDGSSSSASSTATSNTEENDIDEETMSGENDVEYN-NMELEEGELMEDAAAA- B4DGZ3_HUMAN B4DGZ3_HUMAN YEDEVNQLDGSSSSASSTATSNTEENDIDEETMSGENDVEYN-NMELEEGELMEDAAAA- A8K0V9_HUMAN A8K0V9_HUMAN YEDEVNQLDGSSSSASSTATSNTEENDIDEETMSGENDVEYN-NMELEEGELMEDAAAA- TRI37_HUMAN TRI37_HUMAN YEDEVNQLDGSSSSASSTATSNTEENDIDEETMSGENDVEYN-NMELEEGELMEDAAAA- A8K8U4_HUMAN A8K8U4_HUMAN YEDEVNQLDGSSSSASSTATSNTEENDIDEETMSGENDVEYN-NMELEEGELMEDAAAA- MATCH ***.*:*:**.********* *******************. .*:****:**** ::* CONSENSUS ?EDEVN?LDGSSSSASSTATSNTEENDIDEETMSGENDVEYN??MELEEGELMEDAAAA?

A1L1D3_XENTR A1L1D3_XENTR --GAAAGGHGY--GSGRNSRRTGSNIGSTSSSSLLDLDPLIFIHLLDLKDRNSMENLWSL Q5ZLV6_CHICK Q5ZLV6_CHICK APGASGTSHGYTSASGRPSRRGGSALGSAASSSLLDIDPLILIHLLDLKDRNGMENLWGL Q5SX31_MOUSE Q5SX31_MOUSE --GPPGSSHSYVGASSRMSRRT--HLCSAATSSLLDIDPLILIHLLDLKDRSSMENLWGL TRI37_MOUSE TRI37_MOUSE --GPPGSSHSYVGASSRMSRRT--HLCSAATSSLLDIDPLILIHLLDLKDRSSMENLWGL B5DF77_RAT B5DF77_RAT --GPPGSSHSYVGASSRMSRRA--HLCSAATSSLLDIDPLILIHLLDLKDRSSMENLWGL A8WFQ1_BOVIN A8WFQ1_BOVIN --GPPGGNHGYVGASSRMSRRA--HLCSAATSSLLDIDPLILIHLLDLKDRSSMENLWGL Q95LW3_MACFA Q95LW3_MACFA --GPAGSNHGYVGSGSRISRRT--HLCSAATSSLLDIDPLILIHLLDLKDRSSIENLWGL Q5RE26_PONAB Q5RE26_PONAB --GPAGSSHGYVGSSSRISRRT--HLCSAATSSLLDIDPLILIHLLDLKDRSSIENFWRL A8MTM4_HUMAN A8MTM4_HUMAN --GPAGSSHGYVGSSSRISRRT--HLCSAATSSLLDIDPLILIHLLDLKDRSSIENLWGL B4DGZ3_HUMAN B4DGZ3_HUMAN --GPAGSSHGYVGSSSRISRRT--HLCSAATSSLLDIDPLILIHLLDLKDRSSIENLWGL A8K0V9_HUMAN A8K0V9_HUMAN --GPAGSSHGYVGSSSRISRRT--HLCSAATSSLLDIDPLILIHLLDLKDRSSIENLWGL TRI37_HUMAN TRI37_HUMAN --GPAGSSHGYVGSSSRISRRT--HLCSAATSSLLDIDPLILIHLLDLKDRSSIENLWGL A8K8U4_HUMAN A8K8U4_HUMAN --GPAGSSHGYVGSSSRISRRT--HLCSAATSSLLDIDPLILMHLLDLKDRSSIENLWGL MATCH *... .*.* ...* *** : *:::*****:****::********..:**:* * CONSENSUS ??GP?G??H?YVG?SSR?SRR???HLCSAATSSLLDIDPLILIHLLDLKDRSS?ENLWGL

A1L1D3_XENTR A1L1D3_XENTR QPRPPTSILQASA-SCSRKERDQRRQQTSWRVSPDLKMLKRYKSQVLEVRSKLSAVKNQL Q5ZLV6_CHICK Q5ZLV6_CHICK QPRPPASILQSRASSYSLKDRDLRRHQAMWRVPPDLKMLKRLKTQMAEVRSKMSDVKNQL Q5SX31_MOUSE Q5SX31_MOUSE QPRPSASLLQPTA-SYSRKDKDQRKQQAMWRVPSDLKMLKRLKTQMAEVRCMKTDVKTTL TRI37_MOUSE TRI37_MOUSE QPRPSASLLQPTA-SYSRKDKDQRKQQAMWRVPSDLKMLKRLKTQMAEVRCMKTDVKTTL B5DF77_RAT B5DF77_RAT QPRPSASLLQPTA-SYSRKDKDQRKQQAMWRVPSDLKMLKRLKTQMAEVRCMKTDVKTTL A8WFQ1_BOVIN A8WFQ1_BOVIN QPRPPAS-LQPTA-SYSRKDKDQRKQQAMWRVPSDLKMLKRLKTQMAEVRC-KADIKNTL Q95LW3_MACFA Q95LW3_MACFA QPRPPASLLQPTA-SYSRKDKDQRKQQAMWRVPSDLKMLKRLKTQMAEVRCMKTDVKNTL Q5RE26_PONAB Q5RE26_PONAB QPRPPASLLQPTA-SYSRKDKDQRKQQAMWRVPSDLKMLKRLKTQMAEVRCMKTDVKNTL A8MTM4_HUMAN A8MTM4_HUMAN QPRPPASLLQPTA-SYSRKDKDQRKQQAMWRVPSDLKMLKRLKTQMAEVRCMKTDVKNTL B4DGZ3_HUMAN B4DGZ3_HUMAN QPRPPASLLQPTA-SYSRKDKDQRKQQAMWRVPSDLKMLKRLKTQMAEVRCMKTDVKNTL A8K0V9_HUMAN A8K0V9_HUMAN QPRPPASLLQPTA-SYSRKDKDQRKQQAMWRVPSDLKMLKRLKTQMAEVRCMKTDVKNTL TRI37_HUMAN TRI37_HUMAN QPRPPASLLQPTA-SYSRKDKDQRKQQAMWRVPSDLKMLKRLKTQMAEVRCMKTDVKNTL A8K8U4_HUMAN A8K8U4_HUMAN QPRPPASLLQPTA-SYSRKDKDQRKQQAMWRVPSDLKMLKRLKTQMAEVRCMKTDVKNTL MATCH ****.:* **. * * * *::* *::*: ***..******* *:*: ***. : :*. * CONSENSUS QPRP?AS?LQPTA?SYSRKDKDQRKQQAMWRVPSDLKMLKRLKTQMAEVRC?K?DVK?TL

A1L1D3_XENTR A1L1D3_XENTR CEVRNNNTAVTENHCG-STGDLDSLTSSSAEGCTKLQELGMELLRKSSLASCYVRSASSK Q5ZLV6_CHICK Q5ZLV6_CHICK SEVRSSNAGSCDGQPNFFSIEQGALAACGTDGCSKLQEIGMELLTKSSVTSCYIRNSASK Q5SX31_MOUSE Q5SX31_MOUSE SDIKGSSVASTDMQTNLFCADQAALTTCGPENSGRLQDLGMELLAKSSVAGCYIRNPTNK TRI37_MOUSE TRI37_MOUSE SDIKGSSVASTDMQTNLFCADQAALTTCGPENSGRLQDLGMELLAKSSVAGCYIRNPTNK B5DF77_RAT B5DF77_RAT ADIKGSSVASADLQTNLFCADQAALATCGPENSGRLQDLGMELLAKSSVAGCYIRNR--- A8WFQ1_BOVIN A8WFQ1_BOVIN SEIKSSSAASGDMAASLLSADQAALAACGTENSSRLQELGMELLAKSSVASCYIRNSTNK Q95LW3_MACFA Q95LW3_MACFA SEIKSSIAASGDMQTSLFSADQAALAACGTENSGRLQDLGMELLAKSSVASCYIRNSTNK Q5RE26_PONAB Q5RE26_PONAB SEIKSSSAASGDMQTSLFSADQAALAACGTENSGRLQDLGMELLAKSSVASCYIRNSTNK A8MTM4_HUMAN A8MTM4_HUMAN SEIKSSSAASGDMQTSLFSADQAALAACGTENSGRLQDLGMELLAKSSVANCYIRNSTNK B4DGZ3_HUMAN B4DGZ3_HUMAN SEIKSSSAASGDMQTSLFSADQAALAACGTENSGRLQDLGMELLAKSSVANCYIRNSTNK A8K0V9_HUMAN A8K0V9_HUMAN SEIKSSSAASGDMQTSLFSADQAALAACGTENSGRLQDLGMELLAKSSVANCYIRNSTNK TRI37_HUMAN TRI37_HUMAN SEIKSSSAASGDMQTSLFSADQAALAACGTENSGRLQDLGMELLAKSSVANCYIRNSTNK A8K8U4_HUMAN A8K8U4_HUMAN SEIKSSSAASGDMQTSLFSADQAALAACGTENSGRLQDLGMELLAKSSVANCYIRNSTNK MATCH .:::.. .. : . : :*::...:.. :**::***** ***::.**:*. CONSENSUS S?IK?S??AS?D?Q??LF?ADQAAL??CG?ENS?RLQ?LGMELLAKSSVA?CYIRN???K

A1L1D3_XENTR A1L1D3_XENTR KSNSPKHSRSGEKAGALSLRRAMECGEGSHRVKAESQATSEGCSTGTKNVSRHGSPRSLT Q5ZLV6_CHICK Q5ZLV6_CHICK KRDSPKPIRSG-AAGSLSLRRAMDCGDNNLRLKGDGQT-CEGGAGSSKSSSRHHCPRPLA Q5SX31_MOUSE Q5SX31_MOUSE K-NSPKSARA--IAGSLSLRRAVDSGENS-RSKGDCQVLAEGSSGSSQSGSRHSSPRALT TRI37_MOUSE TRI37_MOUSE K-NSPKSARA--IAGSLSLRRAVDSGENS-RSKGDCQVLAEGSSGSSQSGSRHSSPRALT B5DF77_RAT B5DF77_RAT ------------------------------------------SPGSSQSGSRHSSPRALT A8WFQ1_BOVIN A8WFQ1_BOVIN KSHSPKPARSS-VAGSLSLRRAIDSGENS-RSKGDCQTLAEVSPGSSQSGSRHSSPRALT Q95LW3_MACFA Q95LW3_MACFA KSNSPKPARSS-VAGSLSLRRAVDPGESS-RSKGDCQTLSEGSPGSSQSGSRHSSPRALI Q5RE26_PONAB Q5RE26_PONAB KSNSPKPARSS-VAGSLSLRRAVDPGENS-RSKGDCQTLSEGSPGSSQSGSRHSSPRALI A8MTM4_HUMAN A8MTM4_HUMAN KSNSPKPARSS-VAGSLSLRRAVDPGENS-RSKGDCQTLSEGSPGSSQSGSRHSSPRALI B4DGZ3_HUMAN B4DGZ3_HUMAN KSNSPKPARSS-VAGSLSLRRAVDPGENS-RSKGDCQTLSEGSPGSSQSGSRHSSPRALI A8K0V9_HUMAN A8K0V9_HUMAN KSNSPKPARSS-VAGSLSLRRAVDPGENS-RSKGDCQTLSEGSPGSSQSGSRHSSPRALI TRI37_HUMAN TRI37_HUMAN KSNSPKPARSS-VAGSLSLRRAVDPGENS-RSKGDCQTLSEGSPGSSQSGSRHSSPRALI A8K8U4_HUMAN A8K8U4_HUMAN KSNSPKPARSS-VAGSLSLRRAVDPGENS-RSKGDCQTLSEGSPGSSQSGSRHSSPRALI MATCH . .::. *** .**.* CONSENSUS K??SPK??R????AGSLSLRRA?D?GE?S?R?KGD?Q???EGS?GSSQSGSRHSSPRAL?

A1L1D3_XENTR A1L1D3_XENTR NSSPEIPSSSKTDERQSELLSSEIQAMC-------MDKGRKVISLGPSSKGWSGKDIVQM Q5ZLV6_CHICK Q5ZLV6_CHICK SSNAS-EALPKPEERPCEGSDSD-VGVSGLNGLAAVEKTRKAGALGSNPKG-YRTEGTQS Q5SX31_MOUSE Q5SX31_MOUSE HGIIG-DLLPKSEDRQCKALDSDAVVVAVFNGLPTVEKRRKMVTLGTNAKG-GRLEGMQM TRI37_MOUSE TRI37_MOUSE HGIIG-DLLPKSEDRQCKALDSDAVVVAVFNGLPTVEKRRKMVTLGTNAKG-GRLEGMQM B5DF77_RAT B5DF77_RAT HGIIG-DLLPKSEDRQCKALDSDAVVVAVFNGLPTVEKRRKMVTLGTNVKG-GRLEGMQL A8WFQ1_BOVIN A8WFQ1_BOVIN HVSIS-DILPKSEDRQCQALDSDAVVVAVFNGVPVVEKRRKMVTLGTNATG-SRLEGMQM Q95LW3_MACFA Q95LW3_MACFA HGSIG-DILPKTEDRQCKALDSDAVVVAVFSGLPAVEKRRKMVTLGANAKG-GHLEGLQM Q5RE26_PONAB Q5RE26_PONAB HGSIG-DILPKTEDRQCKALDSDAVVVAVFSGLPAVEKRRKMVTLGANAKG-GHLEGLQM A8MTM4_HUMAN A8MTM4_HUMAN HGSIG-DILPKTEDRQCKALDSDAVVVAVFSGLPAVEKRRKMVTLGANAKG-GHLEGLQM B4DGZ3_HUMAN B4DGZ3_HUMAN HGSIG-DILPKTEDRQCKALDSDAVVVAVFSGLPAVEKRRKMVTLGANAKG-GHLEGLQM A8K0V9_HUMAN A8K0V9_HUMAN HGSIG-DILPKTEDRQCKALDSDAVVVAVFSGLPAVEKRRKMVTLGANAKG-GHLEGLQM TRI37_HUMAN TRI37_HUMAN HGSIG-DILPKTEDRQCKALDSDAVVVAVFSGLPAVEKRRKMVTLGANAKG-GHLEGLQM A8K8U4_HUMAN A8K8U4_HUMAN HGSIG-DILPKTEDRQCKALDSDAVVVAVFSGLPAVEKRRKMVTLGANAKG-GHLEGLQM MATCH .*.::* .: .*: :. ::* ** :**.. .* : * CONSENSUS H??I??D?LPK?EDRQC?ALDSDAVVVAVF?GLP?VEKRRKMVTLG?N?KG???LEG?QM

A1L1D3_XENTR A1L1D3_XENTR GSLDSDHEAGEITSMLSEVASVTYPEEAAVCSKLVLHILPGMSSDSDIECDTENEEQEEN Q5ZLV6_CHICK Q5ZLV6_CHICK GGLEDSSETGELQGVLPEGASAG-PEEGGSCQKHVLHLLPGMSSDSDIECDTENEEQEDA Q5SX31_MOUSE Q5SX31_MOUSE ADLESHSEAGEVQPTLPEGASAA-PEE-------------GMSSDSDIECDTENEEQEEH TRI37_MOUSE TRI37_MOUSE ADLESHSEAGEVQPTLPEGASAA-PEE-------------GMSSDSDIECDTENEEQEEH B5DF77_RAT B5DF77_RAT ADLESPSDAGEVQPTLPEGASAA-PEE-------------GMSSDSDIECDTENEEQEEH A8WFQ1_BOVIN A8WFQ1_BOVIN TDSENNSETGELQPVLPEGASAA-PED-------------GMSSDSDIECDTESEEREER Q95LW3_MACFA Q95LW3_MACFA TDLENNSETGELQPVLPEGASAA-PEE-------------GMSSDSDIECDTENEEQEEH Q5RE26_PONAB Q5RE26_PONAB TDLENNSETGELQPVLPEGASAG-PEE-------------GMSSDSDIECDTENEEQEEH A8MTM4_HUMAN A8MTM4_HUMAN TDLENNSETGELQPVLPEGASAA-PEE-------------GMSSDSDIECDTENEEQEEH B4DGZ3_HUMAN B4DGZ3_HUMAN TDLENNSETGELQPVLPEGASAA-PEE-------------GMSSDSDIECDTENEEQGEH A8K0V9_HUMAN A8K0V9_HUMAN TDLENNSETGELQPVLPEGASAA-PEE-------------GMSSDSDIECDTENEEQEEH TRI37_HUMAN TRI37_HUMAN TDLENNSETGELQPVLPEGASAA-PEE-------------GMSSDSDIECDTENEEQEEH A8K8U4_HUMAN A8K8U4_HUMAN TDLENNSETGELQPVLPEGASAA-PEE-------------GMSSDSDIECDTENEEQEEH MATCH . :. ::**: *.* **. **: *************.**: : CONSENSUS ?DLE??SE?GE?QP?LPEGASA??PEE?????????????GMSSDSDIECDTENEEQEE?

A1L1D3_XENTR A1L1D3_XENTR ITCG-GFNDSFTS--QAQGEDQGRSFPDEDNNISSEDLHFPAGEDTGR------------ Q5ZLV6_CHICK Q5ZLV6_CHICK TSTSEGFNHAFSVQSSSEASERCSAFPGGD-QVGTDDLSFVNGEDTTR------------ Q5SX31_MOUSE Q5SX31_MOUSE TSMG-AFNDPFLA--QPPDEDSHSSFPDGE-QIDPENLHFNPDEGGGR------------ TRI37_MOUSE TRI37_MOUSE TSMG-AFNDPFLA--QPPDEDSHSSFPDGE-QIDPENLHFNPDEGGGR------------ B5DF77_RAT B5DF77_RAT TSMG-AFNDPFLA--QPPDEDSHSSFPDGE-QIDPENLHFNTDEGSGRLLVLGTQQPYCE A8WFQ1_BOVIN A8WFQ1_BOVIN AGMG-GFGDAFMA--QPPDEDTHSSFPDGE-QIGPEDLSFSTDENSGR------------ Q95LW3_MACFA Q95LW3_MACFA TSVG-GFHDSFMAMTQPPDEDTHSSFPDGE-QIGPEDLSFNPDENSGR------------ Q5RE26_PONAB Q5RE26_PONAB TSVG-GFHDSFMVMTQPPDEDTHSSFPDGE-QTGPEDLSFNTDENSGR------------ A8MTM4_HUMAN A8MTM4_HUMAN TSVG-GFHDSFMVMTQPPDEDTHSSFPDGE-QIGPEDLSFNTDENSGR------------ B4DGZ3_HUMAN B4DGZ3_HUMAN TSVG-GFHDSFMVMTQPPDEDTHSSFPDGE-QIGPEDLSFNTDENSGR------------ A8K0V9_HUMAN A8K0V9_HUMAN TSVG-GFHDSFMVMTQPPDEDTHSSFPDGE-QIGPEDLSFNTDENSGR------------ TRI37_HUMAN TRI37_HUMAN TSVG-GFHDSFMVMTQPPDEDTHSSFPDGE-QIGPEDLSFNTDENSGR------------ A8K8U4_HUMAN A8K8U4_HUMAN TSVG-GFHDSFMVMTQPPDEDTHSSFPDGE-QIGPEDLSFNTDENSGR------------ MATCH . .* ..* .. .: :**. : : ..::* * .*. * CONSENSUS TS?G??F?D?F????QPPDED?HSSFPDGE?QI?PE?L?F??DE??GR????????????

A1L1D3_XENTR A1L1D3_XENTR ----------------------------------- Q5ZLV6_CHICK Q5ZLV6_CHICK ----------------------------------- Q5SX31_MOUSE Q5SX31_MOUSE ----------------------------------- TRI37_MOUSE TRI37_MOUSE ----------------------------------- B5DF77_RAT B5DF77_RAT EVQTSQPGETACTGSHGYELRPLAPANSHHQLPDV A8WFQ1_BOVIN A8WFQ1_BOVIN ----------------------------------- Q95LW3_MACFA Q95LW3_MACFA ----------------------------------- Q5RE26_PONAB Q5RE26_PONAB ----------------------------------- A8MTM4_HUMAN A8MTM4_HUMAN ----------------------------------- B4DGZ3_HUMAN B4DGZ3_HUMAN ----------------------------------- A8K0V9_HUMAN A8K0V9_HUMAN ----------------------------------- TRI37_HUMAN TRI37_HUMAN ----------------------------------- A8K8U4_HUMAN A8K8U4_HUMAN ----------------------------------- MATCH CONSENSUS ???????????????????????????????????


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