Alignment of the gene Family HBG057659 of HOVERGEN

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Isoforms are ON
Q08CY3_XENTR Q08CY3_XENTR ----------------------------MLRWLCLCSALCALTHGSSARSLEWFTALVRT RN149_XENLA RN149_XENLA ----------------------------MLRWLCLYSALCALTHGSSARSLEWFTALVRT RN149_HUMAN RN149_HUMAN ---------------MAWRRREASVGARGVLALALLALAL-CVPGARGRALEWFSAVVNI RN149_MOUSE RN149_MOUSE -------------MAARRRPAAGVGARDALAVLALALCTP----GVGGGALEWYSAMVSI Q4T8Y9_TETNG Q4T8Y9_TETNG -----------MAPGSIVAACRSLALSTWLLSFCFVHLLC-LDFTV-AEREEWYTAFVNI RN150_DANRE RN150_DANRE -----------MAL-SVIQACRSLALSTWLLSFCFVHLLC-LDFTV-AEKEEWYTAFVNI Q4ST39_TETNG Q4ST39_TETNG --------RTITMAPSVVRACRSLALSTWLLSFSFVHLLC-LDFTV-AEKEEWYTAFVNI B8A6H5_DANRE B8A6H5_DANRE ------------MVVSLTQACRSLALSTWLLSFCFVHLLC-LDFTV-AEKEEWYTAFVNI B4F6W1_XENTR B4F6W1_XENTR ------------MAMSLIQACRSLALSTWLLSFCFVHLLC-LDFTV-AEKEEWYTAFVNI RN150_HUMAN RN150_HUMAN ------------MAMSLIQACCSLALSTWLLSFCFVHLLC-LDFTV-AEKEEWYTAFVNI RN150_MOUSE RN150_MOUSE ------------MTMSLIQACRSLALSTWLLSFCFVHLLC-LDFTV-AEKEEWYTAFVNI Q4SVA5_TETNG Q4SVA5_TETNG ---------------------------LLLLLLCSCSALA-ARSDRGVVPEEHVGATVNA Q4THC0_TETNG Q4THC0_TETNG ---------------------------LLLLLLCSCSALA-ARSDRGVVLEEHVGATVNA Q501T3_DANRE Q501T3_DANRE ----------------------------------------------MVNKEDYYSAIVNA A4II82_XENTR A4II82_XENTR ------------QTGLKMIPRRSLQYLNCLPILVLFPCSM-VQSGSDTANMENYSALVNV A8WGT8_XENTR A8WGT8_XENTR -----------------MIPRRSLQYLNCLPILVLFPCSM-VQSGSDTANMENYSALVNV Q5DTJ1_MOUSE Q5DTJ1_MOUSE -----GPRAAAAAAAGGTMSGAARAGPARLAALALLTCSL-WPTRADNASQEYYTALINV B2GVA8_RAT B2GVA8_RAT ------------------MSGAARAGPARLAALALLTCSL-WPTRADNASQEYYTALINV GOLI_RAT GOLI_RAT ------------------MSGAARAGPARLAALALLTCSL-WPTRADNASQEYYTALINV GOLI_MOUSE GOLI_MOUSE ------------------MSGAARAGPARLAALALLTCSL-WPTRADNASQEYYTALINV Q5SVR5_MOUSE Q5SVR5_MOUSE ------------------MSGAARAGPARLAALALLTCSL-WPTRADNASQEYYTALINV Q59EL1_HUMAN Q59EL1_HUMAN -APAPEPGPRAAAAAGGTMSCAGRAGPARLAALALLTCSL-WPARADNASQEYYTALINV A5PJQ3_BOVIN A5PJQ3_BOVIN ------------------MSGAARAGPARLAAFALLTCSL-WPARADNASQEYYTALINV Q6QN08_CHILA Q6QN08_CHILA ------------------------------------------------------------ GOLI_HUMAN GOLI_HUMAN ------------------MSCAGRAGPARLAALALLTCSL-WPARADNASQEYYTALINV Q1WWL6_HUMAN Q1WWL6_HUMAN ------------------------------------------------------------ Q2HIY3_HUMAN Q2HIY3_HUMAN ------------------------------------------------------------ RN133_HUMAN RN133_HUMAN ------------MHLLKVGTWRNNTASSWLMKFSVLWLVS----QNCCRASVVWMAYMNI RN133_MACFA RN133_MACFA ------------MHLLKVGTWRNNTAFSWLIMFGVLWLVS----QNCCRASVVWTAYMNI Q1KN77_OREMO Q1KN77_OREMO ---------------------MGEKTQPRLLLLLFLSGLV-----HCSATFVFWTANVEI Q4SHP0_TETNG Q4SHP0_TETNG -----------------MGKRGQRCLLLWLCLSGLVRSSA---------AFVFWTAEVEI B5X2U6_SALSA B5X2U6_SALSA -----------------MEPLAKRYLLSWLFVASSLQVTS-LHFAE---ATYICTAYLNV Q6NX00_DANRE Q6NX00_DANRE -----------------MGPLASRDVFSWLLLASVLQVSS-VRLAE---ASYLCTAYLNI A4D0X4_HUMAN A4D0X4_HUMAN ------------MSFLRITPSTHSSVSSGLLRLSIFLLLS-FPDSN---GKAIWTAHLNI RN148_HUMAN RN148_HUMAN ------------MSFLRITPSTHSSVSSGLLRLSIFLLLS-FPDSN---GKAIWTAHLNI RN148_BOVIN RN148_BOVIN ------------MSLLRITSSAHSSASSRLWRLGIFLLLS-LPDSK---GKAIWTAHLNI Q8CGR1_MOUSE Q8CGR1_MOUSE LLCVSCLSVNGEMNPLGPTPSVHRSVSFWLLRLSVFLLLS-FRDSK---GKAIWTAHLNI Q9D3V4_MOUSE Q9D3V4_MOUSE LLCVSCLSVNGEMNPLGPTPSVHRSVSFWLLRLSVFLLLS-LRDSK---GKAIWTAHLNI B7ZQ86_XENLA B7ZQ86_XENLA -----------------MGALKMRCQCFPLPYLSLLALLL-LNLSL-TRAETLWTANVNY RN128_XENLA RN128_XENLA -----------------MGALKMRCQCFPLPYLSLLALLL-LNLSL-TRAETLWTANVNY B0JZ92_XENTR B0JZ92_XENTR ------------------------------------------------------------ B1H231_RAT B1H231_RAT --------------------------MNRKTKYSFLQLLVIFTFLLRSTASFSMNAYVTV A2AGL8_MOUSE A2AGL8_MOUSE --------------------------MNRKTKHSFLQLLVFFTFLLQSTASFSMNAYVTV RN128_BOVIN RN128_BOVIN ----------MGQLPGAGVFCRGGCGFSRLLAWCFLLVLS-PQTPGSRGAEAVWTAYLNV B1AVW8_MOUSE B1AVW8_MOUSE ----------MGPPPGIGVYCRGGCGAARLLAWCFLLALS-PHAPGSRGAEAVWTAYLNV RN128_MOUSE RN128_MOUSE ----------MGPPPGIGVYCRGGCGAARLLAWCFLLALS-PHAPGSRGAEAVWTAYLNV B2RZ84_RAT B2RZ84_RAT ----------MGPPPGIGVYCRGGCGAARLLAWCFLLALS-PHAPGSRGAEAVWTAYLNV RN128_PONAB RN128_PONAB ----------MGPPLGAGVSCRGGCGSSRLLAWCFLLALS-PQAPGSRGAEAVWTAYLNV RN128_HUMAN RN128_HUMAN ----------MGPPPGAGVSCRGGCGFSRLLAWCFLLALS-PQAPGSRGAEAVWTAYLNV Q5JSK4_HUMAN Q5JSK4_HUMAN -----------------------------------------------------MSAYVTV A0PJI4_HUMAN A0PJI4_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ?????????????????????????????L?????????????????????????A????

Q08CY3_XENTR Q08CY3_XENTR EYTEPLT--N---------STVTGSTESGRYGDSSPKDTVQGLVGYPRDPW---QLEGCH RN149_XENLA RN149_XENLA EYTEPLT--N---------SSVTGSTESGRYGDSSPKESVKGFVGYPRDPW---QLEGCH RN149_HUMAN RN149_HUMAN EYVDPQT--N---------LTVWSVSESGRFGDSSPKEGAHGLVGVPWAPGG--DLEGCA RN149_MOUSE RN149_MOUSE EYVDPQS--N---------LTVWSVSESGRFGESSLREERQGLVGVPRAPA---PAEGCA Q4T8Y9_TETNG Q4T8Y9_TETNG SYLDPAN--S---------EPHTEKTECGRYGEHSPKRDAKGLLVLPASPH---DRQACD RN150_DANRE RN150_DANRE TYVDPDT--A---------EVRTEKTECGRYGEHSLKREARGVLAMPAAPH---DRHACD Q4ST39_TETNG Q4ST39_TETNG TYLDPVS--S---------EVRMEKTECGRYGEHSPKKEVKGLVLVPSLPQ---DRQACD B8A6H5_DANRE B8A6H5_DANRE TYLDPVT--S---------EIKTDRSECGRYGEHSPKRDARGFVFMPQ------DRQACD B4F6W1_XENTR B4F6W1_XENTR TYTDPLS--H---------QWRTEKSECGRYGEHSLKQDAWGLAVMPSSPQ---DRLACD RN150_HUMAN RN150_HUMAN TYAEPAPDPGAGAAGGGGAELHTEKTECGRYGEHSPKQDARGEVVMASSAH---DRLACD RN150_MOUSE RN150_MOUSE TYLEPEPGAAV-AGSGGGAELHTEKSECGRYGEHSPKQDARGEVVMASSAQ---DRLACD Q4SVA5_TETNG Q4SVA5_TETNG TVLDGRG--N---------VVQVMSSVDGRYGQNSPKVDARGVVLTPAPRNGVVDRQGCD Q4THC0_TETNG Q4THC0_TETNG TVLDGRG--N---------VVQVMSSVDGSYGQNSPKVDARGVVLTPAPRNGVVDRQGCD Q501T3_DANRE Q501T3_DANRE TVLDHKG--N---------PQQMVTKNDGRYGQNSPKTEAKGIVVAPAAVNGAVDLQGCC A4II82_XENTR A4II82_XENTR TIQDPS---S---------NPVLLRIDGGRYGLDSPKTEAKGLLLTPVHIHGAADRLGCD A8WGT8_XENTR A8WGT8_XENTR TIQDPS---S---------NPVLLRIDGGRYGLDSPKTEAKGLLLTPVHIHGAADRLGCD Q5DTJ1_MOUSE Q5DTJ1_MOUSE TVQEPGR--G---------TPLTFRIDRGRYGLDSPKAEVRGQVLAPLPIHGVADHLGCD B2GVA8_RAT B2GVA8_RAT TVQEPGR--G---------TPLTFRIDRGRYGLDSPKAEVRGQVLAPLPI---------- GOLI_RAT GOLI_RAT TVQEPGR--G---------TPLTFRIDRGRYGLDSPKAEVRGQVLAPLPIHGVADHLGCD GOLI_MOUSE GOLI_MOUSE TVQEPGR--G---------TPLTFRIDRGRYGLDSPKAEVRGQVLAPLPIHGVADHLGCD Q5SVR5_MOUSE Q5SVR5_MOUSE TVQEPGR--G---------TPLTFRIDRGRYGLDSPKAEVRGQVLAPLPIHGVADHLGCD Q59EL1_HUMAN Q59EL1_HUMAN TVQEPGR--G---------APLTFRIDRGRYGLDSPKAEVRGQVLAPLPLHGVADHLGCD A5PJQ3_BOVIN A5PJQ3_BOVIN TVQEPGR--G---------APLTFRIDRGRYGLDSPKAEVRGQVLAPLPIHGVADHLGCD Q6QN08_CHILA Q6QN08_CHILA ------------------------------------------------------------ GOLI_HUMAN GOLI_HUMAN TVQEPGR--G---------APLTFRIDRGRYGLDSPKAEVRGQVLAPLPLHGVADHLGCD Q1WWL6_HUMAN Q1WWL6_HUMAN --------------------------------------------CVPLTLHGVADHLGCD Q2HIY3_HUMAN Q2HIY3_HUMAN ------------------------------------------------------------ RN133_HUMAN RN133_HUMAN SFHVG----N---------HVLSELGETGVFGRSSTLKRVAGVIVPPEGK----IQNACN RN133_MACFA RN133_MACFA SFHVG----N---------HVLSELGETGVFGRSSTLKRVAGVIVPPEGK----IQNACN Q1KN77_OREMO Q1KN77_OREMO SFVNSYN------------ETEEKYCECGLYGRNSPVRSASGIVTLPVG-----DPKGCG Q4SHP0_TETNG Q4SHP0_TETNG KYWNGVD--D---------KLVAKICECGVFGRNSDVTEIFGSVVLPTG-----DLEGCG B5X2U6_SALSA B5X2U6_SALSA SFIDSVN--N---------ETVWRQEESGLYGQQSPKVTVMGDVYLPDP------IYSCE Q6NX00_DANRE Q6NX00_DANRE SYTNPEN--N---------RSTWFQEEMGLYGQDSPKAYVKGNVYLASP------TYGCD A4D0X4_HUMAN A4D0X4_HUMAN TFQVG----N---------EITSELGESGVFGNHSPLERVSGVVALPEG-W---NQNACH RN148_HUMAN RN148_HUMAN TFQVG----N---------EITSELGESGVFGNHSPLERVSGVVALPEG-W---NQNACH RN148_BOVIN RN148_BOVIN TFQVG----S---------RLISELGESGVFGNHSPLERVSGVVVLPEG-W---NQNACN Q8CGR1_MOUSE Q8CGR1_MOUSE TFQVG----N---------RIISELGESGVFGNHSPLERVSGAVVLPEG-W---NQNACS Q9D3V4_MOUSE Q9D3V4_MOUSE TFQVG----N---------RIISELGESGVFGNHSPLERVSGAVVLPEG-W---NQNACS B7ZQ86_XENLA B7ZQ86_XENLA SYVYD----N---------KTYGEEGEIGVFGQDSPIERAAGLVVLPKSEK---LYTACK RN128_XENLA RN128_XENLA SYVYD----N---------KTYGEEGEIGVFGQDSPIERAAGLVVLPKSEK---LYTACK B0JZ92_XENTR B0JZ92_XENTR ------------------------------------------------------------ B1H231_RAT B1H231_RAT TYFNESS--N---------DTKTETCECGVYGLASPVDNAMGVVGIPRNG----NHQACD A2AGL8_MOUSE A2AGL8_MOUSE TYFNESS--N---------YTKTERCECGVYGLVSLVANAMGVVGIPKNG----NYQACD RN128_BOVIN RN128_BOVIN SWRVPHTGVN---------RTVWELSEEGVYGQDSPLEPVAGVLVPPDGPG---ALNACN B1AVW8_MOUSE B1AVW8_MOUSE SWRVPHTGVN---------RTVWELSEEGVYGQDSPLEPVSGVLVPPDGPG---ALNACN RN128_MOUSE RN128_MOUSE SWRVPHTGVN---------RTVWELSEEGVYGQDSPLEPVSGVLVPPDGPG---ALNACN B2RZ84_RAT B2RZ84_RAT SWRVPHPGVN---------RTVWELSEEGVYGQDSPLEPVSGVLVPPDGPG---ALNACN RN128_PONAB RN128_PONAB SWRVPHTGVN---------RTVWELSEEGVYGQDSPLEPVAGVLVPPDGPG---ALNACN RN128_HUMAN RN128_HUMAN SWRVPHTGVN---------RTVWELSEEGVYGQDSPLEPVAGVLVPPDGPG---ALNACN Q5JSK4_HUMAN Q5JSK4_HUMAN TYYNETS--N---------YTAIETCECGVYGLASPVANAMGVVGIPKNN----NYQACD A0PJI4_HUMAN A0PJI4_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????G??G??S??????G????P???????????C?

Q08CY3_XENTR Q08CY3_XENTR PDTQYIVPGMPASP------APDSDWIALIAR-GGCTFKEKVFNAANRGASAVVIYNE-A RN149_XENLA RN149_XENLA PDTQYIVPGTSAAAAAGPDSEWTQPWIALVAR-GGCTFKEKVFNAANRGASAVVIYNE-A RN149_HUMAN RN149_HUMAN PDTRFFVP--------EPGGRGAAPWVALVAR-GGCTFKDKVLVAARRNASAVVLYNE-E RN149_MOUSE RN149_MOUSE PDTRFVAPGA----------LGNAPWVALVAR-GGCSFKDKVLAAARRNASAVVVYNL-E Q4T8Y9_TETNG Q4T8Y9_TETNG PSTRFSVP------------AQAGPWVALVAR-GNCTYKDKIRHAAAYNASAVVIFNVGS RN150_DANRE RN150_DANRE PSGRFT-P------------RAHGAWIALISR-GNCTYKDKIRHAVGHNASAVVIFNVGS Q4ST39_TETNG Q4ST39_TETNG PNVRFPPV------------APNTAWVALVAS-GNCTFREKIRNVANLNASAIVIYNVGS B8A6H5_DANRE B8A6H5_DANRE GNTRFPLP------------HPSIPWIALIAK-GNCTFREKIRHAAALNASAVVIFNVGS B4F6W1_XENTR B4F6W1_XENTR PATKFSVP------------ANASRWVALIPK-GNCTYRDKIKHAALQNASAVLIYNVGS RN150_HUMAN RN150_HUMAN PNTKFAAP------------TRGKNWIALIPK-GNCTYRDKIRNAFLQNASAVVIFNV-G RN150_MOUSE RN150_MOUSE PNTKFAAP------------AHGKHWIALIPK-GNCTYRDKIRNAFLQNASAVVIFNV-G Q4SVA5_TETNG Q4SVA5_TETNG PATRFLVP------------ARTVQWVALLQR-GNCTFKEKILKAASFNATAVLIYN--- Q4THC0_TETNG Q4THC0_TETNG PATRFLVP------------ARTVQWVALLQR-GNCTFKEKILKAASFNATAVLIYN--- Q501T3_DANRE Q501T3_DANRE PHTRFIVP------------PKTTHWVAIMQR-GKCTFKEKILKAAAFNASAVIIYN--N A4II82_XENTR A4II82_XENTR PQTRFNVP------------PNTKHWIALLQR-GNCTFKEKILRAASHNASAVVIYN--N A8WGT8_XENTR A8WGT8_XENTR PQTRFNVP------------PNTKHWIALLQR-GNCTFKEKILRAASHNASAVVIYN--N Q5DTJ1_MOUSE Q5DTJ1_MOUSE PQTRFFVP------------PNIKQWIALLQR-GNCTFKEKISRAAFHNAVAVVIYN--N B2GVA8_RAT B2GVA8_RAT ------------------------------------------------------------ GOLI_RAT GOLI_RAT PQTRFFVP------------PNIKQWIALLQR-GNCTFKEKISRAAFHNAVAVVIYN--N GOLI_MOUSE GOLI_MOUSE PQTRFFVP------------PNIKQWIALLQR-GNCTFKEKISRAAFHNAVAVVIYN--N Q5SVR5_MOUSE Q5SVR5_MOUSE PQTRFFVP------------PNIKQWIALLQR-GNCTFKEKISRAAFHNAVAVVIYN--N Q59EL1_HUMAN Q59EL1_HUMAN PQTRFFVP------------PNIKQWIALLQR-GNCTFKEKISRAAFHNAVAVVIYN--N A5PJQ3_BOVIN A5PJQ3_BOVIN PQTRFFVP------------PNIKQWIALLQR-GNCTFKEKISRAAFHNAVAVVIYN--N Q6QN08_CHILA Q6QN08_CHILA -------------------------------------FKEKISRAAFHNAVAVVIYN--N GOLI_HUMAN GOLI_HUMAN PQTRFFVP------------PNIKQWIALLQR-GNCTFKEKISRAAFHNAVAVVIYN--N Q1WWL6_HUMAN Q1WWL6_HUMAN PQTRFFVP------------PNIKQWIALLQR-GNCTFKEKISRAAFHNAVAVVIYN--N Q2HIY3_HUMAN Q2HIY3_HUMAN ------------------------------------------------------------ RN133_HUMAN RN133_HUMAN PNTIFSRS------------KYSETWLALIER-GGCTFTQKIKVATEKGASGVIIYNV-P RN133_MACFA RN133_MACFA PNTIFSRS------------KYSETWLALIER-GGCTFTQKIKVAAEKGASGVIIYNF-P Q1KN77_OREMO Q1KN77_OREMO PDPVYGRN------------TTSPPWIALVKR-GNCTFGEKINAAKRLGAAAVVVYNV-D Q4SHP0_TETNG Q4SHP0_TETNG SGPLYSH-------------NNSTSWIALVKR-GNCTFSEKINAAKRQGAAGVVVFNA-D B5X2U6_SALSA B5X2U6_SALSA SNTFYDVP------------SGSKGWIALIQRGQLCSFSEKINVAASKGAIAAVIFND-L Q6NX00_DANRE Q6NX00_DANRE DDTFYGRP------------NGSKGWIALIQRGNGCTFTEKINIAAMNGAAAAIIFND-F A4D0X4_HUMAN A4D0X4_HUMAN PLTNFSRP------------KQADSWLALIER-GGCTFTHKINVAAEKGANGVIIYNY-Q RN148_HUMAN RN148_HUMAN PLTNFSRP------------KQADSWLALIER-GGCTFTHKINVAAEKGANGVIIYNY-Q RN148_BOVIN RN148_BOVIN PMTNFSRP------------GQTDPWLALIER-GGCTFTRKINVAAEKGANGVIIYNY-P Q8CGR1_MOUSE Q8CGR1_MOUSE PLTNFSRP------------DQTDTWLALIER-GGCTFTHKINLAAEKGANGVIIYNY-P Q9D3V4_MOUSE Q9D3V4_MOUSE PLTNFSRP------------DQTDTWLALIER-GGCTFTHKINLAAEKGANGVIIYNY-P B7ZQ86_XENLA B7ZQ86_XENLA DNVNFSVPS-----------GWTGPWIALIQRGGGCTFTEKINRAAERGARAVVVYN--N RN128_XENLA RN128_XENLA DNVNFSVPS-----------GWTGPWIALIQRGGGCTFTEKINRAAERGARAVVVYN--N B0JZ92_XENTR B0JZ92_XENTR ----------------------------LILRGGGCTFTEKINRAAERGARAVVVYN--N B1H231_RAT B1H231_RAT YNTEFT--------------NTDKPWIALIER-GNCTFSEKIQIASRSNADAVVIYNS-P A2AGL8_MOUSE A2AGL8_MOUSE YNTEFT--------------NTAKPWIALIER-GNCTFSEKIQTASRSNANAVVIYNS-P RN128_BOVIN RN128_BOVIN PHTNFTVPTVPGD----WGSSVQVSWLALIQRGGGCTFADKIHLAYERGASGAVIFNF-P B1AVW8_MOUSE B1AVW8_MOUSE PHTNFTVPTV-------WGSTVQVSWLALIQRGGGCTFADKIHLASERGASGAVIFNF-P RN128_MOUSE RN128_MOUSE PHTNFTVPTV-------WGSTVQVSWLALIQRGGGCTFADKIHLASERGASGAVIFNF-P B2RZ84_RAT B2RZ84_RAT PHTNFTVPTV-------WGSTVQVSWLALIQRGGGCTFADKIHLAYERGASGAVIFNF-P RN128_PONAB RN128_PONAB PHTNFTVPTV-------WGSTVQVSWLALIQRGGGCTFADKIHLAYERGASGAVIFNF-P RN128_HUMAN RN128_HUMAN PHTNFTVPTV-------WGSTVQVSWLALIQRGGGCTFADKIHLAYERGASGAVIFNF-P Q5JSK4_HUMAN Q5JSK4_HUMAN HNTEFS--------------NTKKPWIALIER-GNCTFSEKIQTAGRRNADAVVIYNA-P A0PJI4_HUMAN A0PJI4_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ?????????????????????????W?AL??R?G?CTF??KI??A????A????I?N???

Q08CY3_XENTR Q08CY3_XENTR KSGNATVSMSHLGTGNTVVIMVSYPKGMEILEPMRRDIPVKMVITMGTRHVQEFISGQSV RN149_XENLA RN149_XENLA KSGNATVSMSHLGTGNTVVIMVSYPKGMEIMEPLRRDIPVKMVITVGTRHVQEFISGQSV RN149_HUMAN RN149_HUMAN RYGNITLPMSHAGTGNIVVIMISYPKGREILELVQKGIPVTMTIGVGTRHVQEFISGQSV RN149_MOUSE RN149_MOUSE SNGNATEPMSHAGTGNIVVIMISYPKGREIFDLVQKGIPVKMRIEIGTRHMQEFISGQSV Q4T8Y9_TETNG Q4T8Y9_TETNG THSNDTITMPHQGTGEVVAIMIPEAKGRELTSLLEHNVTVTMIITIGTRNLQKYVSRTSV RN150_DANRE RN150_DANRE SNPNETITMPHQGISDVVAIMIPEPKGRELVLLMERNITVHMHITIGTRNLQKYVSRTSV Q4ST39_TETNG Q4ST39_TETNG SSANDTITMSHPGTGSIVAVMIPEPKGREIMALLERNIVITLHITIGTRNLQKYVSRTSV B8A6H5_DANRE B8A6H5_DANRE SNSNDTITMPHHGTGDVVAIMIPEPKGREIMALLEKNITVAMHISIGTRNLQKYVSRTSV B4F6W1_XENTR B4F6W1_XENTR SNANETITMPHPGIEDIVAIMIPEPKGREIATLLERNINVTIYITIGTRNLQKYVSRTSV RN150_HUMAN RN150_HUMAN SNTNETITMPHAGVEDIVAIMIPEPKGKEIVSLLERNITVTMYITIGTRNLQKYVSRTSV RN150_MOUSE RN150_MOUSE SNTNETITMPHAGVEDIVAIMIPEPKGKEIVSLLERNITVTMYITIGTRNLQKYVSRTSV Q4SVA5_TETNG Q4SVA5_TETNG NFTEKTVMMGHEGTGDTVAVMITEAFGKELLAHLDRNLTVLVSVLF---RPTKNINRGSL Q4THC0_TETNG Q4THC0_TETNG NFTEKTVMMGHEGTGDTVAVMITEAFGKELLAHLDRNLTVLVSVLF---RPTKNINRGSL Q501T3_DANRE Q501T3_DANRE NTKEDTVTMAHEGTGDIVAVMITESFGKEILGFLEKNQTVLVSVIVGSRGMPKNINRGSL A4II82_XENTR A4II82_XENTR NSKEETVTMTHQGTGEIVAIMISEARGREILSYVERNISVLMAIAVGSRNQHKNFSRGSL A8WGT8_XENTR A8WGT8_XENTR NSKEETVTMTHQGTGEIVAIMISEARGREILSYVERNISVLMAIAVGSRNQHKNFSRGSL Q5DTJ1_MOUSE Q5DTJ1_MOUSE KSKEEPVTMTHPGTGDIIAVMITELRGKDILSYLEKNISVQMTIAVGTRMPPKNFSRGSL B2GVA8_RAT B2GVA8_RAT ----------HGGTGDIIAVMITELRGKDILSYLEKNISVQMTIAVGTRMPPKNFSRGSL GOLI_RAT GOLI_RAT KSKEEPVTMTHPGTGDIIAVMITELRGKDILSYLEKNISVQMTIAVGTRMPPKNFSRGSL GOLI_MOUSE GOLI_MOUSE KSKEEPVTMTHPGTGDIIAVMITELRGKDILSYLEKNISVQMTIAVGTRMPPKNFSRGSL Q5SVR5_MOUSE Q5SVR5_MOUSE KSKEEPVTMTHPGTGDIIAVMITELRGKDILSYLEKNISVQMTIAVGTRMPPKNFSRGSL Q59EL1_HUMAN Q59EL1_HUMAN KSKEEPVTMTHPGTGDIIAVMITELRGKDILSYLEKNISVQMTIAVGTRMPPKNFSRGSL A5PJQ3_BOVIN A5PJQ3_BOVIN KSKEEPVTMTHPGTGDIIAVMITELRGKDILSYLEKNISVQMTIAVGTRMPPKNFSRGSL Q6QN08_CHILA Q6QN08_CHILA KSKEEPVTMTHPGTGDIIAVMITELRGKDIWSYLEKNISVQMTIAVGTRMPPKNFSRGSL GOLI_HUMAN GOLI_HUMAN KSKEEPVTMTHPGTGDIIAVMITELRGKDILSYLEKNISVQMTIAVGTRMPPKNFSRGSL Q1WWL6_HUMAN Q1WWL6_HUMAN KSKEEPVTMTHPGTGDIIAVMITELRGKDILSYLEKNISVQMTIAVGTRMPPKNFSRGSL Q2HIY3_HUMAN Q2HIY3_HUMAN --------MTHPGTGDIIAVMITELRGKDILSYLEKNISVQMTIAVGTRMPPKNFSRGSL RN133_HUMAN RN133_HUMAN GTGNQVFPMFHQAFEDVVVVMIGNLKGTEIFHLIKKGVLITAVVEVGRKHII-WMNHYLV RN133_MACFA RN133_MACFA GTGNQVFPMFHQAFEDVVVVMIGNLKGTEIFHLIKKGVLITAMVEVGRKHII-WMNHYLV Q1KN77_OREMO Q1KN77_OREMO GSGNSTTHMAHSDAGDIVAIMIGNTQGMEIVRLLKNGIDVQMIISEGMAHGP-WMDTYWL Q4SHP0_TETNG Q4SHP0_TETNG GTGNSTSQMFHPEAVDTVAIMIGNGQGMGVVRLLRNGTDVEMLIKPGKPHGP-WVDTYWL B5X2U6_SALSA B5X2U6_SALSA GTDNRVIQMSHPGTEGMVAIMIGHRRGMEIVELIRQGIPVSMTIEVGKQHGP-WMSHYSV Q6NX00_DANRE Q6NX00_DANRE GSENRVIQMSHPGTT-IVAIMIGNYRGMELVQLLDQGVPVAIAIEVGKQHGP-WMSHYSV A4D0X4_HUMAN A4D0X4_HUMAN GTGSKVFPMSHQGTENIVAVMISNLKGMEILHSIQKGVYVTVIIEVGRMHMQ-WVSHYIM RN148_HUMAN RN148_HUMAN GTGSKVFPMSHQGTENIVAVMISNLKGMEILHSIQKGVYVTVIIEVGRMHMQ-WVSHYIM RN148_BOVIN RN148_BOVIN GTGNKVFPMSHQGTENIVAVMIGNLKGMELLHLIQKGVYVKIIIEVGRMHMP-WLSHYIM Q8CGR1_MOUSE Q8CGR1_MOUSE GTGNKVFPMSHQGTENIVAVMIGNLKGMELLHLIQQGVYVTIIIEVGRMHMP-WLSHYVM Q9D3V4_MOUSE Q9D3V4_MOUSE GTGNKVFPMSHQGTENIVAVMIGNLKGMELLHLIQQGVYVTIIIEVGRMHMP-WLSHYVM B7ZQ86_XENLA B7ZQ86_XENLA GIDNEVFEMSHPGTKDTVAIMIGNLKGNEIVDLIKGGMQVTMVIEVGRKHGS-WINHYSI RN128_XENLA RN128_XENLA GIDNEVFEMSHPGTKDTVAIMIGNLKGNEIVDLIKGGMQVTMVIEVGRKHGS-WINHYSI B0JZ92_XENTR B0JZ92_XENTR GMDNEVFEMSHPGTKDTVAIMIGNIKGNEIVELIKGGMQVMMVIEVGRKHGS-WINHYSI B1H231_RAT B1H231_RAT ETGNQTIQMANFGAGDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGP-WVNHYSI A2AGL8_MOUSE A2AGL8_MOUSE ETGNQTIQMANFGAGDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGP-WVNHYSI RN128_BOVIN RN128_BOVIN GTRNEVIPMSHPGAGDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGP-WVNHYSI B1AVW8_MOUSE B1AVW8_MOUSE GTRNEVIPMSHPGAGDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGP-WVNHYSI RN128_MOUSE RN128_MOUSE GTRNEVIPMSHPGAGDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGP-WVNHYSI B2RZ84_RAT B2RZ84_RAT GTRNEVIPMSHPGAGDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGP-WVNHYSI RN128_PONAB RN128_PONAB GTRNEVIPMSHPGAGDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGP-WVNHYSI RN128_HUMAN RN128_HUMAN GTRNEVIPMSHPGAVDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGP-WVNHYSI Q5JSK4_HUMAN Q5JSK4_HUMAN ETGNQTIQMANFGAVDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGP-WVNHYSI A0PJI4_HUMAN A0PJI4_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ????????M?H?G?????A?MI????G??I?????????V???I??G???????????S?

Q08CY3_XENTR Q08CY3_XENTR VFVAIAFITMMIISLAWLIFYYIQRF--LYTGAQCGNQSN-RKETKKAISQLQLHRVKKG RN149_XENLA RN149_XENLA VFVAIAFITMMIISLAWLIFYYIQRF--LYTGAQCGNQSN-RKETKKAISQLQLHRVKKG RN149_HUMAN RN149_HUMAN VFVAIAFITMMIISLAWLIFYYIQRF--LYTGSQIGSQSH-RKETKKVIGQLLLHTVKHG RN149_MOUSE RN149_MOUSE VFVAIAFITMMIISLAWLIFYYIQRF--LYTGSQFGSQNH-RKETKKVIGQLPLHTVKHG Q4T8Y9_TETNG Q4T8Y9_TETNG VFVSISFIVLMIISLAWLVFYYIQRF--RYANARDRNQRRLGDAAKKAISKLQVRTIRKG RN150_DANRE RN150_DANRE VFVSISFIILMIISLAWLVFYYIQRF--RYANARDRNQRRLGDAAKKAISQLQVRTIRKG Q4ST39_TETNG Q4ST39_TETNG VFVSISFIILMIISLAWLVFYYIQRF--RYANARNRNQRRLDDAAKKAISKLQVRTIKKG B8A6H5_DANRE B8A6H5_DANRE VFVSISFIVLMIISLAWLVFYYIQRF--RYANARDRSQRRLGDAAKKAISKLQVRTIRKG B4F6W1_XENTR B4F6W1_XENTR VFVSISFIVLMIISLAWLVFYYIQRF--RYANARDRNQRRLGDAAKKAISKLQVRTIKKG RN150_HUMAN RN150_HUMAN VFVSISFIVLMIISLAWLVFYYIQRF--RYANARDRNQRRLGDAAKKAISKLQIRTIKKG RN150_MOUSE RN150_MOUSE VFVSISFIVLMIISLAWLVFYYIQRF--RYANARDRNQRRLGDAAKKAISKLQVRTIRKG Q4SVA5_TETNG Q4SVA5_TETNG VFVSISFIVLMIISTAWFIFYFIQKI--GSRSSQHRGQRHLGDAAKKAIGKLSTRTVKKG Q4THC0_TETNG Q4THC0_TETNG VFVSISFIVLMIISTAWFIFYFIQKI--GSRSSQHRGQRHLGDAAKKAIGKLSTRTVKKG Q501T3_DANRE Q501T3_DANRE VFVSISFIVLMIISSAWLIFYFIQKI--RDTSARDRSQRRLGDAAKKAISKLTTRTVKRG A4II82_XENTR A4II82_XENTR VFVSISFIVLMIISSAWLIFYFIQKI--RYTSARDRNQRRLGDAAKKAIGKLTTRTVKKG A8WGT8_XENTR A8WGT8_XENTR VFVSISFIVLMIISSAWLIFYFIQKI--RYTSARDRNQRRLGDAAKKAIGKLTTRTVKKG Q5DTJ1_MOUSE Q5DTJ1_MOUSE VFVSISFIVLMIISSAWLIFYFIQKI--RYTNARDRNQRRLGDAAKKAISKLTTRTVKKG B2GVA8_RAT B2GVA8_RAT VFVSISFIVLMIISSAWLIFYFIQKI--RYTNARDRNQRRLGDAAKKAISKLTTRTVKKG GOLI_RAT GOLI_RAT VFVSISFIVLMIISSAWLIFYFIQKI--RYTNARDRNQRRLGDAAKKAISKLTTRTVKKG GOLI_MOUSE GOLI_MOUSE VFVSISFIVLMIISSAWLIFYFIQKI--RYTNARDRNQRRLGDAAKKAISKLTTRTVKKG Q5SVR5_MOUSE Q5SVR5_MOUSE VFVSISFIVLMIISSAWLIFYFIQKI--RYTNARDRNQRRLGDAAKKAISKLTTRTVKKG Q59EL1_HUMAN Q59EL1_HUMAN VFVSISFIVLMIISSAWLIFYFIQKI--RYTNARDRNQRRLGDAAKKAISKLTTRTVKKG A5PJQ3_BOVIN A5PJQ3_BOVIN VFVSISFIVLMIISSAWLIFYFIQKI--RYTNARDRNQRRLGDAAKKAISKLTTRTVKKG Q6QN08_CHILA Q6QN08_CHILA VFVSISFIVLMIISSAWLIFYFIQKI--RYTNARDRNQRRLGDAAKKAISKLTTRTVKKG GOLI_HUMAN GOLI_HUMAN VFVSISFIVLMIISSAWLIFYFIQKI--RYTNARDRNQRRLGDAAKKAISKLTTRTVKKG Q1WWL6_HUMAN Q1WWL6_HUMAN VFVSISFIVLMIISSAWLIFYFIQKI--RYTNARDRNQRRLGDAAKKAISKLTTRTVKKG Q2HIY3_HUMAN Q2HIY3_HUMAN VFVSISFIVLMIISSAWLIFYFIQKI--RYTNARDRNQRRLGDAAKKAISKLTTRTVKKG RN133_HUMAN RN133_HUMAN -----SFVIVTTATLAYFIFYHIHRL--CLARIQNRRWQRLTTDLQNTFGQLQLRVVKEG RN133_MACFA RN133_MACFA -----SFVIVTTATLAYFIFYHIHRL--CLARIQNRRWQRLTTDLQNAFGQLQLRVVKEG Q1KN77_OREMO Q1KN77_OREMO YFLSIAFFIVTAASIAYFVFISANRL--YNMSRSKRNENRLKSEAKKAIKRLQVRTLNRG Q4SHP0_TETNG Q4SHP0_TETNG YLLSIAFFVVTAASVTYFIFLSASRL--YRLRRHQRNERRLKSKAKKAIRCLQVRTLTRD B5X2U6_SALSA B5X2U6_SALSA FFVSISFFVVTAATVGYFIFYSARRL--NSVRLQNRKQKRLKAEAKKAIGQLQVRTVKRG Q6NX00_DANRE Q6NX00_DANRE FFVSISFFIVTAATVGYFIFYSARRL--NSLRQQNRSQKKLKAEAKKAIGQLQVRTLRQG A4D0X4_HUMAN A4D0X4_HUMAN -----YLFTFLAATIAYFYLDCVWRLTPRVPNSFTRRRSQIKTDVKKAIDQLQLRVLKEG RN148_HUMAN RN148_HUMAN -----YLFTFLAATIAYFYLDCVWRLTPRVPNSFTRRRSQIKTDVKKAIDQLQLRVLKEG RN148_BOVIN RN148_BOVIN -----SLFTFLTATVAYLFLYCAWRP--RGPNFSTRRQRQLKADVRKAIGKLQLRVLQEG Q8CGR1_MOUSE Q8CGR1_MOUSE -----SLFTFLAATVTYLFLYCAWRP--RVSNSSTRRQRQLKADVKKAIGQLQLRVLQDG Q9D3V4_MOUSE Q9D3V4_MOUSE -----SLFTFLAATVTYLFLYCAWRP--RVSNSSTRRQRQLKADVKKAIGQLQLRVLQDE B7ZQ86_XENLA B7ZQ86_XENLA FFVSVSFFIVTAATVGYFIFYSARRW--RLTRAQNKKQKRLKAEAKKAIGKLQLRTIKQG RN128_XENLA RN128_XENLA FFVSVSFFIVTAATVGYFIFYSARRW--RLTRAQNKKQKRLKAEAKKAIGKLQLRTIKQG B0JZ92_XENTR B0JZ92_XENTR FFVSVSFFIVTAATVGYFIFYSARRW--RLTRAQNKKMKQLKAEAKKAIGKLQLRTIKQG B1H231_RAT B1H231_RAT FFVSVSFFIITAATVGYFIFYSARRL--RNARAQSRKQRQLKADAKKAIGRLQLRTLKQG A2AGL8_MOUSE A2AGL8_MOUSE FFVSVSFFIITAATVGYFIFYSARRL--RNARAQSRKQRQLKADAKKAIGKLQLRTLKQG RN128_BOVIN RN128_BOVIN FFVSVSFFIITAATVGYFIFYSARRL--RNARAQSRKQRQLKADAKKAIGRLQLRTQKQG B1AVW8_MOUSE B1AVW8_MOUSE FFVSVSFFIITAATVGYFIFYSARRL--RNARAQSRKQRQLKADAKKAIGKLQLRTLKQG RN128_MOUSE RN128_MOUSE FFVSVSFFIITAATVGYFIFYSARRL--RNARAQSRKQRQLKADAKKAIGKLQLRTLKQG B2RZ84_RAT B2RZ84_RAT FFVSVSFFIITAATVGYFIFYSARRL--RNARAQSRKQRQLKADAKKAIGRLQLRTLKQG RN128_PONAB RN128_PONAB FFVSVSFFIITAATVGYFIFYSARRL--RNARAQSRKQRQLKADAKKAIGRLQLRTLKQG RN128_HUMAN RN128_HUMAN FFVSVSFFIITAATVGYFIFYSARRL--RNARAQSRKQRQLKADAKKAIGRLQLRTLKQG Q5JSK4_HUMAN Q5JSK4_HUMAN FFVSVSFFIITAATVGYFIFYSARRL--RNARAQSRKQRQLKADAKKAIGRLQLRTLKQG A0PJI4_HUMAN A0PJI4_HUMAN -----SFFIITAATVGYFIFYSARRL--RNARAQSRKQRQLKADAKKAIGRLQLRTLKQG MATCH :. . : :: : : . ::.: * : CONSENSUS ?FV??SF????????????FY??????????????R?Q??L????KKAI??L??RT?K?G

Q08CY3_XENTR Q08CY3_XENTR EKGIDIDAENCAVCIENYKTKDLVRILPCKHIFHRLCIDPWLIEHRTCPMCKLDVIKALG RN149_XENLA RN149_XENLA EKGIDIDAENCAVCIENYKTKDLVRILPCKHIFHRLCIDPWLIEHRTCPMCKLDVIKALG RN149_HUMAN RN149_HUMAN EKGIDVDAENCAVCIENFKVKDIIRILPCKHIFHRICIDPWLLDHRTCPMCKLDVIKALG RN149_MOUSE RN149_MOUSE EKGIDVDAENCAVCIENFKVKDVIRILPCKHIFHRICIDPWLLDHRTCPMCKLDVIKALG Q4T8Y9_TETNG Q4T8Y9_TETNG DQETETDFDNCAVCIEGYKANDVVRILPCRHLFHKSCVDPWLLDHRTCPMCKMNILKALG RN150_DANRE RN150_DANRE DQETESDFDNCAVCIEGYKPNDVVRILPCRHLFHKCCVDPWLVDHRTCPMCKMNILKALG Q4ST39_TETNG Q4ST39_TETNG DEETESDFDNCAVCIEGYRPNDVVRILPCRHVFHKHCVDPWLQEHRTCPMCKMNILKALG B8A6H5_DANRE B8A6H5_DANRE DKETDSDFDNCAVCIEDYKPNDVVRILPCRHVFHRNCVDPWLQDHRTCPMCKMNILKALG B4F6W1_XENTR B4F6W1_XENTR DKETEPEFDNCAVCIEGYKPNDVVRILPCRHLFHKSCVDPWLLDHRTCPMCKMNILKALG RN150_HUMAN RN150_HUMAN DKETESDFDNCAVCIEGYKPNDVVRILPCRHLFHKSCVDPWLLDHRTCPMCKMNILKALG RN150_MOUSE RN150_MOUSE DKETESDFDNCAVCIEGYKPNDVVRILPCRHLFHKSCVDPWLLDHRTCPMCKMNILKALG Q4SVA5_TETNG Q4SVA5_TETNG DKETHPDFNHCAVCIEAYQLNDVVRILPCKHVFHKVCVDPWLNEHCTCPICKLNILKALG Q4THC0_TETNG Q4THC0_TETNG DKETHPDFNHCAVCIEAYQLNDVVRILPCK------------------------------ Q501T3_DANRE Q501T3_DANRE DKETEPDFNHCAVCIEGYQLNDVVRILPCKHVFHKMCVDPWLNEHCTCPMCKLNILKALG A4II82_XENTR A4II82_XENTR DKETDPDFDHCAVCIESYKQNDIVRVLPCKHVFHKVCVDPWLSEHCTCPMCKLNILKALG A8WGT8_XENTR A8WGT8_XENTR DKETDPDFDHCAVCIESYKQNDIVRVLPCKHVFHKVCVDPWLSEHCTCPMCKLNILKALG Q5DTJ1_MOUSE Q5DTJ1_MOUSE DKVQ-------------------------------------------------------- B2GVA8_RAT B2GVA8_RAT DKETDPDFDHCAVCIESYKQNDVVRVLPCKHVFHKSCVDPWLSEHCTCPMCKLNILKALG GOLI_RAT GOLI_RAT DKETDPDFDHCAVCIESYKQNDVVRVLPCKHVFHKSCVDPWLSEHCTCPMCKLNILKALG GOLI_MOUSE GOLI_MOUSE DKETDPDFDHCAVCIESYKQNDVVRVLPCKHVFHKSCVDPWLSEHCTCPMCKLNILKALG Q5SVR5_MOUSE Q5SVR5_MOUSE DKETDPDFDHCAVCIESYKQNDVVRVLPCKHVFHKSCVDPWLSEHCTCPMCKLNILKALG Q59EL1_HUMAN Q59EL1_HUMAN DKETDPDFDHCAVCIESYKQNDVVRILPCKHVFHKSCVDPWLSEHCTCPMCKLNILKALG A5PJQ3_BOVIN A5PJQ3_BOVIN DKETDPDFDHCAVCIESYKQNDVVRILPCKHVFHKSCVDPWLSEHCTCPMCKLNILKALG Q6QN08_CHILA Q6QN08_CHILA DKETDPDFDHCAVCIESYKQNDVVRILPCKHVFHKSCVDPWLSEHCTCPMCKLN------ GOLI_HUMAN GOLI_HUMAN DKETDPDFDHCAVCIESYKQNDVVRILPCKHVFHKSCVDPWLSEHCTCPMCKLNILKALG Q1WWL6_HUMAN Q1WWL6_HUMAN DKETDPDFDHCAVCIESYKQNDVVRILPCKHVFHKSCVDPWLSEHCTCPMCKLNILKALG Q2HIY3_HUMAN Q2HIY3_HUMAN DKETDPDFDHCAVCIESYKQNDVVRILPCKHVFHKSCVDPWLSEHCTCPMCKLNILKALG RN133_HUMAN RN133_HUMAN DEEINPNGDSCVICFERYKPNDIVRILTCKHFFHKNCIDPWILPHGTCPICKCDILKVLG RN133_MACFA RN133_MACFA DEEINPNGDSCVICFEHYKPNDIVRILTCKHFFHKNCIDPWILSHGTCPICKCDILKVLG Q1KN77_OREMO Q1KN77_OREMO DEETSSDSSMCAVCIESYKVGDVVTVLTCDHIFHKTCIEPWLLERRTCPMCKCDILKALG Q4SHP0_TETNG Q4SHP0_TETNG DEEANSESHMCAVCIESYRMGDVVTVLTCDHIFHKTCIEPWLLEKRTCPMCKCDILKALG B5X2U6_SALSA B5X2U6_SALSA DEETGPDADTCAVCIDAYKSGDVLTILTCNHFFHKTCIEPWLLEHRTCPMCKCDILKALG Q6NX00_DANRE Q6NX00_DANRE DQEIGPDADACAVCIDSYKAGDVLSILTCNHFFHKSCIEPWLLEHRTCPMCKCDILKALG A4D0X4_HUMAN A4D0X4_HUMAN DEELDLNEDNCVVCFDTYKPQDVVRILTCKHFFHKACIDPWLLAHRTCPMCKCDILKT-- RN148_HUMAN RN148_HUMAN DEELDLNEDNCVVCFDTYKPQDVVRILTCKHFFHKACIDPWLLAHRACPMCKCDILKT-- RN148_BOVIN RN148_BOVIN DKELEPDEDNCVVCFDIYKPQDVVRILTCKHIFHKACIDPWLLAHRTCPMCKCDILQT-- Q8CGR1_MOUSE Q8CGR1_MOUSE DKELDPNEDSCVVCFDMYKAQDVIRILTCKHFFHKTCIDPWLLAHRTCPMCKCDILKP-- Q9D3V4_MOUSE Q9D3V4_MOUSE DKELDPNEDSCVVCFDMYKAQDVIRILTCKHFFHKTCIDPWLLAHRTCPMCKCDILKP-- B7ZQ86_XENLA B7ZQ86_XENLA DKVLGPDGDSCAVCIEPYKPSDVVRILTCNHFFHKNCIDPWLLEHRTCPMCKCDILKSLG RN128_XENLA RN128_XENLA DKVLGPDGDSCAVCIEPYKPSDVVRILTCNHFFHKNCIDPWLLEHRTCPMCKCDILKSLG B0JZ92_XENTR B0JZ92_XENTR DKVLGPDGDSCAVCIEPYKPSDVVRILTCNHFFHKNCIDPWLLEHRTCPMCKCDILKSLG B1H231_RAT B1H231_RAT DKEIGPDGDSCAVCIELYKPNDVVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALG A2AGL8_MOUSE A2AGL8_MOUSE DKEIGPDGDSCAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALG RN128_BOVIN RN128_BOVIN DKEIGPDGDSCAVCIELYKPNDLVRILTCNHVFHKTCVDPWLLEHRTCPMCKCDILKALG B1AVW8_MOUSE B1AVW8_MOUSE DKEIGPDGDSCAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALG RN128_MOUSE RN128_MOUSE DKEIGPDGDSCAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALG B2RZ84_RAT B2RZ84_RAT DKEIGPDGDSCAVCIELYKPNDVVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALG RN128_PONAB RN128_PONAB DREIGPDGDSCAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALG RN128_HUMAN RN128_HUMAN DKEIGPDGDSCAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALG Q5JSK4_HUMAN Q5JSK4_HUMAN DKEIGPDGDSCAVCIELYKPNDLVRILTCNHIFHKT------------------------ A0PJI4_HUMAN A0PJI4_HUMAN DKEIGPDGDSCAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALG MATCH :. CONSENSUS D?E???D?D?CAVCIE?YK??D?VRIL?C?H?FHK?C?DPWL??H?TCPMCK??ILK?LG

Q08CY3_XENTR Q08CY3_XENTR FWVEPEET--------VDIHV----------PVSIAGSSLSIGTVSIT---QEESRSEGN RN149_XENLA RN149_XENLA FWVEPEET----------LDI----------HVPDSIAGSSLSIGTVS-ITQEESRSEGN RN149_HUMAN RN149_HUMAN YWGEPGDVQEMPAPESPPGRD----------PAANLSLALPDDDGSDD---SSPPSASPA RN149_MOUSE RN149_MOUSE YWGDPEDTQELPTPEAAPGRV----------SVGNLSVTSQDEERSES------NLPSSS Q4T8Y9_TETNG Q4T8Y9_TETNG IALNTDCLDDLPLDYDLALGGAGGVGVLALEAVVSGASSDGTLSEGGSSLALDPGVRRVG RN150_DANRE RN150_DANRE LTSSAECLNELPLDYELAVGG----------VALNAMVMSDDVMAGDVGGARDPGVRMGG Q4ST39_TETNG Q4ST39_TETNG IPLSADCSDDLPPDYETSIGG----------PPTNPISSASEVTVNESSVVLDSAVRTAD B8A6H5_DANRE B8A6H5_DANRE IPPNTDCSDDAPPDYETSSG-----------QPSIAVTGASEVSVGESSLVLDQPLRITG B4F6W1_XENTR B4F6W1_XENTR IPPNADCLDDIPPDFEGSV-G----------PPTNQITGASDVTVNESSVGIDPSVRTVG RN150_HUMAN RN150_HUMAN IPPNADCMDDLPTDFEGSLGG----------PPTNQITGASDTTVNESSVTLDPAVRTVG RN150_MOUSE RN150_MOUSE IPPNADCMDDLPIDFEGSLGG----------PPTNQITGASDTTVNESSVTLDPAVRTVG Q4SVA5_TETNG Q4SVA5_TETNG ITVGPPWLEVLGW----------------------------------------------- Q4THC0_TETNG Q4THC0_TETNG ------------------------------------------------------------ Q501T3_DANRE Q501T3_DANRE VMPNLPCVDNMAFDMDRMSRS----------QTSSQRTALVDLSSETS--ISLEPLRHSS A4II82_XENTR A4II82_XENTR IAANVPCTDNVAFDMERLTRS----------QPPSRRSAPNDPTEEGS--LSLESLRSSR A8WGT8_XENTR A8WGT8_XENTR IAANVPCTDNVAFDMERLTRS----------QPPSRRSAPNDPTEEGS--LSLESLRSSR Q5DTJ1_MOUSE Q5DTJ1_MOUSE ------------------------------------------------------------ B2GVA8_RAT B2GVA8_RAT IVPNLPCTDNVAFDMERLTRT----------QAVNRRSALGDLANDSS--LGLEPLRTSG GOLI_RAT GOLI_RAT IVPNLPCTDNVAFDMERLTRT----------QAVNRRSALGDLANDSS--LGLEPLRTSG GOLI_MOUSE GOLI_MOUSE IVPNLPCTDNVAFDMERLTRT----------QAVNRRAALGDLAGDSS--LGLEPLRTSG Q5SVR5_MOUSE Q5SVR5_MOUSE IVPNLPCTDNVAFDMERLTRT----------QAVNRRAALGDLAGDSS--LGLEPLRTSG Q59EL1_HUMAN Q59EL1_HUMAN IVPNLPCTDNVAFDMERLTRT----------QAVNRRSALGDLAGDNS--LGLEPLRTSG A5PJQ3_BOVIN A5PJQ3_BOVIN IVPNLPCTDNVAFDMERLTRT----------QAVNRRSALGELASDNS--LGLEPLRTSG Q6QN08_CHILA Q6QN08_CHILA ------------------------------------------------------------ GOLI_HUMAN GOLI_HUMAN IVPNLPCTDNVAFDMERLTRT----------QAVNRRSALGDLAGDNS--LGLEPLRTSG Q1WWL6_HUMAN Q1WWL6_HUMAN IVPNLPCTDNVAFDMERLTRT----------QAVNRRSALGDLAGDNS--LGLEPLRTSG Q2HIY3_HUMAN Q2HIY3_HUMAN IVPNLPCTDNVAFDMERLTRT----------QAVNRRSALGDLAGDNS--LGLEPLRTSG RN133_HUMAN RN133_HUMAN IQVVVENGT-------EPLQV----------LMSNELPETLSPSEEET--NNEVSPAGTS RN133_MACFA RN133_MACFA IQVDVENGT-------EPLQV----------LMSSELCETLSPSEEET--NNEVSPAGTS Q1KN77_OREMO Q1KN77_OREMO VEDDRKES-----------------------FSAESPPDVTVITVTGD---------TLY Q4SHP0_TETNG Q4SHP0_TETNG V----------------------------------------------------------- B5X2U6_SALSA B5X2U6_SALSA VEQPEEEHPSHQVT-----------------MPPDMRSYPSVPVPDDT---RGETASSGY Q6NX00_DANRE Q6NX00_DANRE VELDVEEQ--------PQISV----------PDFRPFSTSEDLHSETASHTHSETASSGY A4D0X4_HUMAN A4D0X4_HUMAN ------------------------------------------------------------ RN148_HUMAN RN148_HUMAN ------------------------------------------------------------ RN148_BOVIN RN148_BOVIN ------------------------------------------------------------ Q8CGR1_MOUSE Q8CGR1_MOUSE ------------------------------------------------------------ Q9D3V4_MOUSE Q9D3V4_MOUSE ------------------------------------------------------------ B7ZQ86_XENLA B7ZQ86_XENLA IAEDEEEGT-------SVAIP----------SVSSELQRSTVQITEEE--NHSETASSGY RN128_XENLA RN128_XENLA IAEDEEEGTSVAI-------P----------SVSSELQRSTVQITEEE--NHSETASSGY B0JZ92_XENTR B0JZ92_XENTR IAEDEEETT-------SAAIP----------SVSSELQRSTVQTIEEE--NRSETASSGY B1H231_RAT B1H231_RAT IEVDVEDGS-------VSLQV----------PVSNEASNTASPHEEDN---RSETASSGY A2AGL8_MOUSE A2AGL8_MOUSE IEVDVEDGS-------VSLQV----------PVSNEASNTASPHEEDS---RSETASSGY RN128_BOVIN RN128_BOVIN IEVDVEDGS-------VSLQV----------PVSNETSSNASPHEEDN---RSETASSGY B1AVW8_MOUSE B1AVW8_MOUSE IEVDVEDGS-------VSLQV----------PVSNEASNTASPHEEDS---RSETASSGY RN128_MOUSE RN128_MOUSE IEVDVEDGS-------VSLQV----------PVSNEASNTASPHEEDS---RSETASSGY B2RZ84_RAT B2RZ84_RAT IEVDVEDGS-------VSLQV----------PVSNEASNTASPHEEDN---RSETASSGY RN128_PONAB RN128_PONAB IEVDVEDGS-------VSLQV----------PVSNEISNSASSHEEDN---RSETASSGY RN128_HUMAN RN128_HUMAN IEVDVEDGS-------VSLQV----------PVSNEISNSASSHEEDN---RSETASSGY Q5JSK4_HUMAN Q5JSK4_HUMAN ------------------------------------------------------------ A0PJI4_HUMAN A0PJI4_HUMAN IEVDVEDGS-------VSLQV----------PVSNEISNSASSHEEDN---RSETASSGY MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q08CY3_XENTR Q08CY3_XENTR NLPSSSTG------SSLQQSNSVK----------------EDAGETTALLDDPGNDNTAG RN149_XENLA RN149_XENLA NLPSSSTG------SSLQQSNSVK----------------DDAGETTALLDDPGNDNAAA RN149_HUMAN RN149_HUMAN ESEPQCDP------SFKGDAGE--NTALLEA----GRSDSRHGGPIS------------- RN149_MOUSE RN149_MOUSE SSESGPHR------PCLKEDAGEDTALLGAG----RSEPQHGGSIC-------------- Q4T8Y9_TETNG Q4T8Y9_TETNG LPQDYQDPDTLRDSPVMAAPDAHTGLTANPE----LQPMASNGSLASLVITVETGLSDEE RN150_DANRE RN150_DANRE LPQVLLDS------EPLSQDTMP---TEQSE----LQPIASGSSDVSLTTGAGHSDIDTP Q4ST39_TETNG Q4ST39_TETNG FQELYANV-------LTEAPSREGSHIISSE----QQPPLSSDSDSSIITGGEVGVSNVC B8A6H5_DANRE B8A6H5_DANRE LSHDYQEM------NSVPADAESPHIASSEQ----HQPSMSNDPDIMPM-------EIAE B4F6W1_XENTR B4F6W1_XENTR VLQVIQDA------ESLPQVGEV-SYTASSE----QEPAVSSDSDISLIMAVDVGLSDVD RN150_HUMAN RN150_HUMAN ALQVVQDT------DPIPQEGDV-IFTTNSE----QEPAVSSDSDISLIMAMEVGLSDVE RN150_MOUSE RN150_MOUSE ALQVVQDP------DPAPQEGEA-IFTTNSG----QEPALSSDSDISLIMALEVGLSDVE Q4SVA5_TETNG Q4SVA5_TETNG ---QCNPC------PPVPRPASPV------------WTALCWMLSVWASLRRPTATSRP- Q4THC0_TETNG Q4THC0_TETNG ------------------------------------------------------------ Q501T3_DANRE Q501T3_DANRE SSQLPSDE------ELIPRSGEI-NIAVTTG----HFFNRNSVSPRSVVCEMELPDIQAS A4II82_XENTR A4II82_XENTR ISQGPHDV------EAIPRTGEI-NISVTKE----WFIIASFGLLSALTLCYMIIKATAS A8WGT8_XENTR A8WGT8_XENTR ISQGPHDV------EAIPRTGEI-NISVTKE----WFIIASFGLLSALTLCYMIIKATAS Q5DTJ1_MOUSE Q5DTJ1_MOUSE ------------------------------------------------------------ B2GVA8_RAT B2GVA8_RAT ISPLPQDG------ELTPRTGEI-NIAVTKE----WFIIASFGLLSALTLCYMIIRATAS GOLI_RAT GOLI_RAT ISPLPQDG------ELTPRTGEI-NIAVTKE----WFIIASFGLLSALTLCYMIIRATAS GOLI_MOUSE GOLI_MOUSE ISPLPQDG------ELTPRTGEI-NIAVTKE----WFIIASFGLLSALTLCYMIIRATAS Q5SVR5_MOUSE Q5SVR5_MOUSE ISPLPQDG------ELTPRTGEI-NIAVTR------------------------------ Q59EL1_HUMAN Q59EL1_HUMAN ISPLPQDG------ELTPRTGEI-NIAVTR------------------------------ A5PJQ3_BOVIN A5PJQ3_BOVIN ISPLPQDG------ELTPRTGEI-NIAVTKE----WFIIASFGLLSALTLCYMIIRATAS Q6QN08_CHILA Q6QN08_CHILA ------------------------------------------------------------ GOLI_HUMAN GOLI_HUMAN ISPLPQDG------ELTPRTGEI-NIAVTKE----WFIIASFGLLSALTLCYMIIRATAS Q1WWL6_HUMAN Q1WWL6_HUMAN ISPLPQDG------ELTPRTGEI-NIAVTKE----WFIIASFGLLSALTLCYMIIRATAS Q2HIY3_HUMAN Q2HIY3_HUMAN ISPLPQDG------ELTPRTGEI-NIAVTKE----WFIIASFGLLSALTLCYMIIRATAS RN133_HUMAN RN133_HUMAN DKVIHVEE------NPTSQNNDI--------------QPHSVVEDVHPSP---------- RN133_MACFA RN133_MACFA DKVIHVEE------NPTSQNNDSQ--------------PHSVVEDVHPSP---------- Q1KN77_OREMO Q1KN77_OREMO EVPLTDPG------SLDPERQQH-------------------------RYDNRAFEEDSE Q4SHP0_TETNG Q4SHP0_TETNG ------------------------------------------------------------ B5X2U6_SALSA B5X2U6_SALSA ASSGYASV------QGTEKHSSPADETHTFETLGNYPDPGSVQVAIQPHYDNLAFEGDSQ Q6NX00_DANRE Q6NX00_DANRE ASMHGNEH------LAPPEGTHN-------------------GVQEEPHYDNLAFESDVH A4D0X4_HUMAN A4D0X4_HUMAN ------------------------------------------------------------ RN148_HUMAN RN148_HUMAN ------------------------------------------------------------ RN148_BOVIN RN148_BOVIN ------------------------------------------------------------ Q8CGR1_MOUSE Q8CGR1_MOUSE ------------------------------------------------------------ Q9D3V4_MOUSE Q9D3V4_MOUSE ------------------------------------------------------------ B7ZQ86_XENLA B7ZQ86_XENLA ASVRGGDE------QV--DEGQHIYENTELV----H-EASATSIEVLPHMDNPGFESE-- RN128_XENLA RN128_XENLA ASVRGGDE------QV--DEGQHIYENTELV-----HEASATSIEVLPHMDNPGFESE-- B0JZ92_XENTR B0JZ92_XENTR ASVRGGDE------PV--DEGQHIYENTELV----HNEASATSIEVLPHVDNPGFESE-- B1H231_RAT B1H231_RAT ASVQGADE------PPLEEHAQSANENLQLV----NHEANSVAVDVVPHVDNPTFEEDET A2AGL8_MOUSE A2AGL8_MOUSE ASVQGADE------PPLEEHAQSANENLQLV----NHEANSVAVDVVPHVDNPTFEEDET RN128_BOVIN RN128_BOVIN ASVQGADE------PPLEEHAHSANENLQLV----NHEANSMAVDVVPHVDNPTFEEDES B1AVW8_MOUSE B1AVW8_MOUSE ASVQGADE------PPLEEHAQSANENLQLV----NHEANSVAVDVVPHVDNPTFEEDET RN128_MOUSE RN128_MOUSE ASVQGADE------PPLEEHAQSANENLQLV----NHEANSVAVDVVPHVDNPTFEEDET B2RZ84_RAT B2RZ84_RAT ASVQGADE------PPLEEHAQSANENLQLV----NHEANSVAVDVVPHVDNPTFEEDET RN128_PONAB RN128_PONAB ASVQGADE------PPLEEHVQSTNENLQLV----NHEANSVAVDVIPHVDNPTFEEDET RN128_HUMAN RN128_HUMAN ASVQGTDE------PPLEEHVQSTNESLQLV----NHEANSVAVDVIPHVDNPTFEEDET Q5JSK4_HUMAN Q5JSK4_HUMAN ------------------------------------------------------------ A0PJI4_HUMAN A0PJI4_HUMAN ASVQGTDE------PPLEEHVQSTNESLQLV----NHEANSVAVDVIPHVDNPTFEEDET MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q08CY3_XENTR Q08CY3_XENTR MNTQDSH----- RN149_XENLA RN149_XENLA THTQDSH----- RN149_HUMAN RN149_HUMAN ------------ RN149_MOUSE RN149_MOUSE ------------ Q4T8Y9_TETNG Q4T8Y9_TETNG G----------- RN150_DANRE RN150_DANRE TDDPKC------ Q4ST39_TETNG Q4ST39_TETNG LSVEPE------ B8A6H5_DANRE B8A6H5_DANRE LQSDLEQEDVKS B4F6W1_XENTR B4F6W1_XENTR LSTDQDCDEAKS RN150_HUMAN RN150_HUMAN LSTDQDCEEVKS RN150_MOUSE RN150_MOUSE LSTDQDCEEVKS Q4SVA5_TETNG Q4SVA5_TETNG ------------ Q4THC0_TETNG Q4THC0_TETNG ------------ Q501T3_DANRE Q501T3_DANRE LDMYDDNKS--- A4II82_XENTR A4II82_XENTR LYATEVEWS--- A8WGT8_XENTR A8WGT8_XENTR LYATEVEWS--- Q5DTJ1_MOUSE Q5DTJ1_MOUSE ------------ B2GVA8_RAT B2GVA8_RAT LNANEVEWF--- GOLI_RAT GOLI_RAT LNANEVEWF--- GOLI_MOUSE GOLI_MOUSE LNANEVEWF--- Q5SVR5_MOUSE Q5SVR5_MOUSE ------------ Q59EL1_HUMAN Q59EL1_HUMAN ------------ A5PJQ3_BOVIN A5PJQ3_BOVIN LNANEVEWF--- Q6QN08_CHILA Q6QN08_CHILA ------------ GOLI_HUMAN GOLI_HUMAN LNANEVEWF--- Q1WWL6_HUMAN Q1WWL6_HUMAN LNANEVEWF--- Q2HIY3_HUMAN Q2HIY3_HUMAN LNANEVEWF--- RN133_HUMAN RN133_HUMAN ------------ RN133_MACFA RN133_MACFA ------------ Q1KN77_OREMO Q1KN77_OREMO AARG-------- Q4SHP0_TETNG Q4SHP0_TETNG ------------ B5X2U6_SALSA B5X2U6_SALSA NQLAPRT----- Q6NX00_DANRE Q6NX00_DANRE NQSEVRT----- A4D0X4_HUMAN A4D0X4_HUMAN ------------ RN148_HUMAN RN148_HUMAN ------------ RN148_BOVIN RN148_BOVIN ------------ Q8CGR1_MOUSE Q8CGR1_MOUSE ------------ Q9D3V4_MOUSE Q9D3V4_MOUSE ------------ B7ZQ86_XENLA B7ZQ86_XENLA ---DVHVHEMKS RN128_XENLA RN128_XENLA ---DVHVHEMKS B0JZ92_XENTR B0JZ92_XENTR ---DVHVHEMKS B1H231_RAT B1H231_RAT PDQEMAVREVKS A2AGL8_MOUSE A2AGL8_MOUSE PDQEAAVREIKS RN128_BOVIN RN128_BOVIN PDQETTVREIKS B1AVW8_MOUSE B1AVW8_MOUSE PDQEAAVREIKS RN128_MOUSE RN128_MOUSE PDQEAAVREIKS B2RZ84_RAT B2RZ84_RAT PDQEMAVREVKS RN128_PONAB RN128_PONAB PHQETAVREIKS RN128_HUMAN RN128_HUMAN PNQETAVREIKS Q5JSK4_HUMAN Q5JSK4_HUMAN ------------ A0PJI4_HUMAN A0PJI4_HUMAN PNQETAVREIKS MATCH CONSENSUS ????????????


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