Alignment of the gene Family HBG057789 of HOVERGEN

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Threshold: 50% 80% 100%
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Isoforms are ON
B3UYC2_BRAFL B3UYC2_BRAFL ------------------------------------------------------------ Q4S8Z6_TETNG Q4S8Z6_TETNG ------------------------------------------------------------ A3RK75_DANRE A3RK75_DANRE ------------------------------------------------------------ FOXO1_XENLA FOXO1_XENLA ------------------------------------------------------------ FOXO1_XENTR FOXO1_XENTR ------------------------------------------------------------ Q9W7F9_CHICK Q9W7F9_CHICK GGRVAAAAAAEGEEPGRAAGPEPRGREPRGSRRPRRRGRADPRSEPAWGGGAEPLRCPPL FOXO1_HUMAN FOXO1_HUMAN ------------------------------------------------------------ FOXO1_SPETR FOXO1_SPETR ------------------------------------------------------------ A4L7N3_PIG A4L7N3_PIG ------------------------------------------------------------ Q8MK69_PIG Q8MK69_PIG ------------------------------------------------------------ Q9ES26_RAT Q9ES26_RAT ------------------------------------------------------------ Q9WVH5_MOUSE Q9WVH5_MOUSE ------------------------------------------------------------ Q8BPP2_MOUSE Q8BPP2_MOUSE ------------------------------------------------------------ Q9JJW4_MOUSE Q9JJW4_MOUSE ------------------------------------------------------------ FOXO1_MOUSE FOXO1_MOUSE ------------------------------------------------------------ Q4RFQ3_TETNG Q4RFQ3_TETNG ------------------------------------------------------------ A3RK74_DANRE A3RK74_DANRE ------------------------------------------------------------ B1AUT2_MOUSE B1AUT2_MOUSE ------------------------------------------------------------ B1AUT3_MOUSE B1AUT3_MOUSE ------------------------------------------------------------ FOXO4_MOUSE FOXO4_MOUSE ------------------------------------------------------------ A6QLP0_BOVIN A6QLP0_BOVIN ------------------------------------------------------------ B4DTB6_HUMAN B4DTB6_HUMAN ------------------------------------------------------------ A6NID2_HUMAN A6NID2_HUMAN ------------------------------------------------------------ A8MXF0_HUMAN A8MXF0_HUMAN ------------------------------------------------------------ FOXO4_HUMAN FOXO4_HUMAN ------------------------------------------------------------ B7WPJ7_HUMAN B7WPJ7_HUMAN ------------------------------------------------------------ B3DGQ4_DANRE B3DGQ4_DANRE ------------------------------------------------------------ Q5TYS1_DANRE Q5TYS1_DANRE ------------------------------------------------------------ Q9W7F8_DANRE Q9W7F8_DANRE ------------------------------------------------------------ B4E1P9_HUMAN B4E1P9_HUMAN ------------------------------------------------------------ Q9WVH4_MOUSE Q9WVH4_MOUSE ------------------------------------------------------------ FOXO3_HUMAN FOXO3_HUMAN ------------------------------------------------------------ B4DVZ6_HUMAN B4DVZ6_HUMAN ------------------------------------------------------------ Q68DV3_HUMAN Q68DV3_HUMAN ------------------------------------------------------------ A2A1E7_PIG A2A1E7_PIG ------------------------------------------------------------ B5UA80_PIG B5UA80_PIG ------------------------------------------------------------ Q1A729_PIG Q1A729_PIG ------------------------------------------------------------ A4IIM7_XENTR A4IIM7_XENTR ------------------------------------------------------------ B7ZS63_XENLA B7ZS63_XENLA ------------------------------------------------------------ FOXO3_XENLA FOXO3_XENLA ------------------------------------------------------------ Q4SV53_TETNG Q4SV53_TETNG ------------------------------------------------------------ Q90YK2_XIPMA Q90YK2_XIPMA ------------------------------------------------------------ Q4REI0_TETNG Q4REI0_TETNG ------------------------------------------------------------ Q5I0F7_DANRE Q5I0F7_DANRE ------------------------------------------------------------ FOXO6_HUMAN FOXO6_HUMAN ------------------------------------------------------------ FOXO6_MOUSE FOXO6_MOUSE ------------------------------------------------------------ Q5RJI9_MOUSE Q5RJI9_MOUSE ------------------------------------------------------------ Q4T8Y3_TETNG Q4T8Y3_TETNG ------------------------------------------------------------ A5PF57_DANRE A5PF57_DANRE ------------------------------------------------------------ B4F6Q7_DANRE B4F6Q7_DANRE ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

B3UYC2_BRAFL B3UYC2_BRAFL -----------------MDMEDPQLEIDPDFEPQSRPRSCTWPLPRPEV----------C Q4S8Z6_TETNG Q4S8Z6_TETNG ------------------------VEIDPEFEPLSRPRSCTWPLPRPEP---------ND A3RK75_DANRE A3RK75_DANRE ----------------MAEPQQQLVDIDPDFEPLSRPRSCTWPLHRPEF--------SEQ FOXO1_XENLA FOXO1_XENLA -------------MAEAPQPPPPLVEIDPDFEPFSRPRSCTWPLPRPEF----------N FOXO1_XENTR FOXO1_XENTR -------------MAEAPLPPPPGVEVDPDFEPFSRPRSCTWPLPRPEF----------N Q9W7F9_CHICK Q9W7F9_CHICK LPAVPLLPAVPLPPAAAMAEAPQLVDIDPDFEPLPRPRSCTWPLPRPEF----------N FOXO1_HUMAN FOXO1_HUMAN -----------------MAEAPQVVEIDPDFEPLPRPRSCTWPLPRPEF----------S FOXO1_SPETR FOXO1_SPETR -----------------MAEAPQVVEIDPDFEPLPRPRSCTWPLPRPEF----------S A4L7N3_PIG A4L7N3_PIG -----------------MAEAPQVVEIDPDFEPLPRPRSCTWPLPRPEF----------S Q8MK69_PIG Q8MK69_PIG -----------------MAEAPQVVEIDPDFEPLPRPRSCTWPLPRPEF----------S Q9ES26_RAT Q9ES26_RAT ------------------------------------------------------------ Q9WVH5_MOUSE Q9WVH5_MOUSE -----------------MAEAPQVVETDPDFEPLPRQRSCTWPLPRPEF----------N Q8BPP2_MOUSE Q8BPP2_MOUSE ------------------------------------------------------------ Q9JJW4_MOUSE Q9JJW4_MOUSE -----------------MAEAPQVVETDPDFEPLPRQRSCTWPLPRPEF----------N FOXO1_MOUSE FOXO1_MOUSE -----------------MAEAPQVVETDPDFEPLPRQRSCTWPLPRPEF----------N Q4RFQ3_TETNG Q4RFQ3_TETNG ------------------AQQPGLVEIDPDFEPLSRPRSCTWPLPRPEF---------IN A3RK74_DANRE A3RK74_DANRE ---------------MADAAQNQMVEIDPDFEPLSRPRSCTWPLPRPEF-------PNPA B1AUT2_MOUSE B1AUT2_MOUSE ---------MDPENKKSATGAAAILDLDPDFEPQSRPRSCTWPLPRPDL----------- B1AUT3_MOUSE B1AUT3_MOUSE ---------MDPENKKSATGAAAILDLDPDFEPQSRPRSCTWPLPRPDL----------- FOXO4_MOUSE FOXO4_MOUSE ---------MDPENKKSATGAAAILDLDPDFEPQSRPRSCTWPLPRPDL----------- A6QLP0_BOVIN A6QLP0_BOVIN ---------MDPVNENSAREAAAIVDLDPDFEPQSRPRSCTWPLPRPEL----------- B4DTB6_HUMAN B4DTB6_HUMAN ---------MDPGNENSATEAAAIIDLDPDFEPQSRPRSCTWPLPRPEI----------- A6NID2_HUMAN A6NID2_HUMAN ---------MDPGNENSATEAAAIIDLDPDFEPQSRPRSCTWPLPRPEI----------- A8MXF0_HUMAN A8MXF0_HUMAN ---------MDPGNENSATEAAAIIDLDPDFEPQSRPRSCTWPLPRPEI----------- FOXO4_HUMAN FOXO4_HUMAN ---------MDPGNENSATEAAAIIDLDPDFEPQSRPRSCTWPLPRPEI----------- B7WPJ7_HUMAN B7WPJ7_HUMAN ---------MDPGNENSATEAAAIIDLDPDFEPQSRPRSCTWPLPRPEI----------- B3DGQ4_DANRE B3DGQ4_DANRE -----------MAETTLEPLSSLDIAIDPDFEPQKRPRSCTWPLPESSM---------AK Q5TYS1_DANRE Q5TYS1_DANRE -----------MAETTLEPLSSLDIAIDPDFEPQKRPRSCTWPLPESSM---------AK Q9W7F8_DANRE Q9W7F8_DANRE -----------MAETTLEPLSSLDIAIDPDFEPQKRPRSCTWPLPESSM---------AK B4E1P9_HUMAN B4E1P9_HUMAN ------------------------------------------------------------ Q9WVH4_MOUSE Q9WVH4_MOUSE ---------MAEAPASPVPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGET FOXO3_HUMAN FOXO3_HUMAN ---------MAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGET B4DVZ6_HUMAN B4DVZ6_HUMAN ------------------------------------------------------------ Q68DV3_HUMAN Q68DV3_HUMAN ------------------------------------------------------------ A2A1E7_PIG A2A1E7_PIG ------------------------------------------------------------ B5UA80_PIG B5UA80_PIG ---------MAEAPASPVPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQGSPAKPSGEA Q1A729_PIG Q1A729_PIG ------------------------------------------------------------ A4IIM7_XENTR A4IIM7_XENTR -----------MAEAVPSLSPPGDVDIDPDFEPQSRPRSCTWPLQRPDSQGSPGKPNSGA B7ZS63_XENLA B7ZS63_XENLA -----------MAEALPPRSPPDDVDIDPDFEPQSRPRSCTWPLQRLDSQGSPGKPNSGA FOXO3_XENLA FOXO3_XENLA -----------MAEALPPRSPPDDVDIDPDFGPQSRPRSCTWPLQRLDSQGSPGKPNSGA Q4SV53_TETNG Q4SV53_TETNG ------------------------------------------------------------ Q90YK2_XIPMA Q90YK2_XIPMA ----------MAEAPLPDTLPDLDVVIDPDFEPQKRPRSCTWPLPRPDS-------SAVK Q4REI0_TETNG Q4REI0_TETNG ------------MAEAPRDEPPSNVEIDPDFEPQKRPRSCTWPLPRPES--------GGK Q5I0F7_DANRE Q5I0F7_DANRE ------------MAEELDKPLAVDVDIDPDFEPQKRPRSCTWPLPRPES-------NSGK FOXO6_HUMAN FOXO6_HUMAN ---------------MAAKLRAHQVDVDPDFAPQSRPRSCTWPLPQPDL----------- FOXO6_MOUSE FOXO6_MOUSE ---------------MAAKLRAHQVDVDPDFAPQSRPRSCTWPLPQPDL----------- Q5RJI9_MOUSE Q5RJI9_MOUSE ---------------MAAKLRAHQVDVDPDFAPQSRPRSCTWPLPQPDL----------- Q4T8Y3_TETNG Q4T8Y3_TETNG ------------------------------------------------------------ A5PF57_DANRE A5PF57_DANRE -----------MLMMESSGIDAHQVELDADYEPHCRPRSCTWPLPCPEE----------- B4F6Q7_DANRE B4F6Q7_DANRE --------------MESSGIDAHQVELDADYEPHCRPRSCTWPLPCPEE----------- MATCH CONSENSUS ???????????????????????????D????P??R?RSCTWPL????????????????

B3UYC2_BRAFL B3UYC2_BRAFL TQESKTEGSPEN----EQ--TTTGEG---------------------------------- Q4S8Z6_TETNG Q4S8Z6_TETNG PASSNTSSPAPS----VQ--QEPGGA----------TDFISNLCLLEEDY---------- A3RK75_DANRE A3RK75_DANRE PGNSNTSSPAPS----VK--PEQGIV-----------DFINSLSLLEETEDYP------- FOXO1_XENLA FOXO1_XENLA PSSSANSSPAPS----LQ--PEPAAG---------NVDFLSNLSLLEESEDFD------- FOXO1_XENTR FOXO1_XENTR PSSSANSSPAPS----LQ--PEPAAG---------NVDFLSNLSLLEESEDFD------- Q9W7F9_CHICK Q9W7F9_CHICK PPSSATSSPAPSCGGQPDGAAAAGAAVAVAASGALSADFISNLCLVEESEDFALPPAA-- FOXO1_HUMAN FOXO1_HUMAN QSNSATSSPAPSGSAAAN--PDAAAGLPSASAAAVSADFMSNLSLLEESEDFPQAPGSVA FOXO1_SPETR FOXO1_SPETR QSNSATSSPAPSGGATAN--PDASAGLPPASAAAVSADFMSNLSLLEESEDFPQAPGSVA A4L7N3_PIG A4L7N3_PIG QSNSATSSPAPSGGAAAN--PDAAAGLPSASAAAVNADFMSNLSLLEESEDFPQAPGSVA Q8MK69_PIG Q8MK69_PIG QSNSATSSPAPSGGPAAN--PDAAAGLPSASAAAVNADFMSNLSLLEESGDFQQAPGSVA Q9ES26_RAT Q9ES26_RAT ------------------------------------------------------------ Q9WVH5_MOUSE Q9WVH5_MOUSE QSNSTTSSPAPSGGAAAN--PDAAASL--ASASAVSTDFMSNLSLLEESEDFARAPG--- Q8BPP2_MOUSE Q8BPP2_MOUSE ------------------------------------------------------------ Q9JJW4_MOUSE Q9JJW4_MOUSE QSNSTTSSPAPSGGAAAN--PDAAASL--ASASAVSTDFMSNLSLLEESEDFARAPG--- FOXO1_MOUSE FOXO1_MOUSE QSNSTTSSPAPSGGAAAN--PDAAASL--ASASAVSTDFMSNLSLLEESEDFARAPG--- Q4RFQ3_TETNG Q4RFQ3_TETNG PGDSNTSSPVPS----VK--QEPAGN----------GDFINNLSLLEESEDFP------- A3RK74_DANRE A3RK74_DANRE AADSNTSSPAPS----VK--QEPSST----------ADFINNLSLLEENEDYP------- B1AUT2_MOUSE B1AUT2_MOUSE ---ATEPHEPSE----VE--PSLGQK---------------------------------- B1AUT3_MOUSE B1AUT3_MOUSE ---ATEPHEPSE----VE--PSLGQK---------------------------------- FOXO4_MOUSE FOXO4_MOUSE ---ATEPHEPSE----VE--PSLGQK---------------------------------- A6QLP0_BOVIN A6QLP0_BOVIN ---APEPSEASE----VE--SGLGEK---------------------------------- B4DTB6_HUMAN B4DTB6_HUMAN ---ANQPSEPPE----VE--PDLGEK---------------------------------- A6NID2_HUMAN A6NID2_HUMAN ---ANQPSEPPE----VE--PDLGEK---------------------------------- A8MXF0_HUMAN A8MXF0_HUMAN ---ANQPSEPPE----VE--PDLGEK---------------------------------- FOXO4_HUMAN FOXO4_HUMAN ---ANQPSEPPE----VE--PDLGEK---------------------------------- B7WPJ7_HUMAN B7WPJ7_HUMAN ---ANQPSEPPE----VE--PDLGEK---------------------------------- B3DGQ4_DANRE B3DGQ4_DANRE PASNDTDIIPEE----ED--DEDDSA---------------------------------- Q5TYS1_DANRE Q5TYS1_DANRE PASNDTDIIPEE----ED--DEDDSA---------------------------------- Q9W7F8_DANRE Q9W7F8_DANRE PASNDTDIIPEE----ED--DEDDSA---------------------------------- B4E1P9_HUMAN B4E1P9_HUMAN ------------------------------------------------------------ Q9WVH4_MOUSE Q9WVH4_MOUSE AADSMIPEEDDD----ED--DEDGGG---------------------------------- FOXO3_HUMAN FOXO3_HUMAN AADSMIPEEEDD----ED--DEDGGG---------------------------------- B4DVZ6_HUMAN B4DVZ6_HUMAN ------------------------------------------------------------ Q68DV3_HUMAN Q68DV3_HUMAN ------------------------------------------------------------ A2A1E7_PIG A2A1E7_PIG ------------------------------------------------------------ B5UA80_PIG B5UA80_PIG AADSMIPEEEDD----ED--DEDGGG---------------------------------- Q1A729_PIG Q1A729_PIG ------------------------------------------------------------ A4IIM7_XENTR A4IIM7_XENTR GEAGDASSMIPE----EE--DDDDEG---------------------------------- B7ZS63_XENLA B7ZS63_XENLA GEAADTSSMIPE----EE--DDDYEG---------------------------------- FOXO3_XENLA FOXO3_XENLA GEAADTSSMIPE----EE--DDDYEG---------------------------------- Q4SV53_TETNG Q4SV53_TETNG ------------------------------------------------------------ Q90YK2_XIPMA Q90YK2_XIPMA PESTEADIIPEE----ED--DEEDSA---------------------------------- Q4REI0_TETNG Q4REI0_TETNG PGTHDTDTPAAA------------------------------------------------ Q5I0F7_DANRE Q5I0F7_DANRE AEPSDVGIIPEE----EV--DENGTD---------------------------------- FOXO6_HUMAN FOXO6_HUMAN ----------------AG--DEDGAL---------------------------------- FOXO6_MOUSE FOXO6_MOUSE ----------------AG--DEDGAL---------------------------------- Q5RJI9_MOUSE Q5RJI9_MOUSE ----------------AG--DEDGAL---------------------------------- Q4T8Y3_TETNG Q4T8Y3_TETNG ------------------------------------------------------------ A5PF57_DANRE A5PF57_DANRE ----ESRALPVK----VE--PRNVPA---------------------------------- B4F6Q7_DANRE B4F6Q7_DANRE ----ESRALPVK----VE--PRNVPA---------------------------------- MATCH CONSENSUS ????????????????????????????????????????????????????????????

B3UYC2_BRAFL B3UYC2_BRAFL -------------GGIEPKTEAGTVPGL-------------------------------- Q4S8Z6_TETNG Q4S8Z6_TETNG -----------VEYGQKPLVPRNDFQEGNSVHLHHHLPPPHPRQHPHQ------------ A3RK75_DANRE A3RK75_DANRE ---------------DEKPVLLNDFHCQDNCAHPQQQHPQQPNPQLT------------- FOXO1_XENLA FOXO1_XENLA --------------PAEALGVCGDFPCQDIRQLQPPIPQQQQQHSQQQQEALTLLA---- FOXO1_XENTR FOXO1_XENTR --------------PAEALGVCGDFPCQDIRQLQPPVPQQHPQQQAGTLCA--------- Q9W7F9_CHICK Q9W7F9_CHICK -----------AAPPESAACRCGDFSAPEAGCRLHPPGPP-------------------- FOXO1_HUMAN FOXO1_HUMAN A------AVAAAAAAAATGGLCGDFQGPEAGCLHPAPP-QPPPPGPL------------- FOXO1_SPETR FOXO1_SPETR -------AAVAAAAAAATGGLCGDFQGLEAGCLHPAPP-QPPPPGPL------------- A4L7N3_PIG A4L7N3_PIG AAAAAAAAVAAAAAAAATGGLCGDFQGPEAGCLHPAPPQQPPPPGPL------------- Q8MK69_PIG Q8MK69_PIG AAAAAAAAVAAAAAAAATGGLCGDFQGPEAGCLHPAPPQQPPPPGPL------------- Q9ES26_RAT Q9ES26_RAT ------------------------------------------------------------ Q9WVH5_MOUSE Q9WVH5_MOUSE -------CVAVAAAAAASRGLCGDFQGPEAGCVHPAPP-QPPPTGPL------------- Q8BPP2_MOUSE Q8BPP2_MOUSE ------------------------------------------------------------ Q9JJW4_MOUSE Q9JJW4_MOUSE -------CVAVAAAAAASRGLCGDFQGPEAGCVHPAPP-QPPPTGPL------------- FOXO1_MOUSE FOXO1_MOUSE -------CVAVAAAAAASRGLCGDFQGPEAGCVHPAPP-QPPPTGPL------------- Q4RFQ3_TETNG Q4RFQ3_TETNG --------------EQKPVVLCTDFQCQETCVHQQPPQQQQQQHNLQHQQHPNPQLTHHH A3RK74_DANRE A3RK74_DANRE --------------DQKPLMLCSEFQCQENCIHQQQIPSQQ------------------- B1AUT2_MOUSE B1AUT2_MOUSE ------------------------------------------------------------ B1AUT3_MOUSE B1AUT3_MOUSE ---------------VPTEGHSEPILLP-------------------------------- FOXO4_MOUSE FOXO4_MOUSE ---------------VPTEGHSEPILLP-------------------------------- A6QLP0_BOVIN A6QLP0_BOVIN ---------------VHPEGRSDGRTQPTLL----------------------------- B4DTB6_HUMAN B4DTB6_HUMAN ---------------VHTEGRSEPILLP-------------------------------- A6NID2_HUMAN A6NID2_HUMAN ---------------VHTEGRSEPILLP-------------------------------- A8MXF0_HUMAN A8MXF0_HUMAN ------------------------------------------------------------ FOXO4_HUMAN FOXO4_HUMAN ---------------VHTEGRSEPILLP-------------------------------- B7WPJ7_HUMAN B7WPJ7_HUMAN ------------------------------------------------------------ B3DGQ4_DANRE B3DGQ4_DANRE -----------MTINANGMGEGEDNGSPSLAEELTSINGQENTGSP-------------- Q5TYS1_DANRE Q5TYS1_DANRE -----------MTINANGMGEGEDNGSPSLAEELISINGQENTGSP-------------- Q9W7F8_DANRE Q9W7F8_DANRE -----------MTINANGMGEGEDNGSPSLAEELISINGQENTGSP-------------- B4E1P9_HUMAN B4E1P9_HUMAN ------------------------------------------------------------ Q9WVH4_MOUSE Q9WVH4_MOUSE -----------RASSAMVIGGGVS-STLGSGLLLEDSAMLLAPGGQDLGSGPASAAGALS FOXO3_HUMAN FOXO3_HUMAN -----------RAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLS B4DVZ6_HUMAN B4DVZ6_HUMAN ------------------------------------------------------------ Q68DV3_HUMAN Q68DV3_HUMAN ------------------------------------------------------------ A2A1E7_PIG A2A1E7_PIG ------------------------------------------------------------ B5UA80_PIG B5UA80_PIG -----------RAGSAMAIGGGGG-GPLGSGLLLEDSARLLAPGGQEPGSGPASAAGALS Q1A729_PIG Q1A729_PIG ------------------------------------------------------------ A4IIM7_XENTR A4IIM7_XENTR -----------SGTTATMVGTAGEKGTVVLLSGGDLTVLASPVGG--------------- B7ZS63_XENLA B7ZS63_XENLA -----------AASTATVLGTAGDKGTLVLLSGGESGQLAVLASPVGG------------ FOXO3_XENLA FOXO3_XENLA -----------AASTATVLGTAGDKGTLVLLSGGESGQLAVLASPVGG------------ Q4SV53_TETNG Q4SV53_TETNG ------------------------------------------------------------ Q90YK2_XIPMA Q90YK2_XIPMA -------------TPTAITVNGSAAATEDQSSNSPITDGAFPSPGHDSGGSPLS------ Q4REI0_TETNG Q4REI0_TETNG ------------------------------------------------------------ Q5I0F7_DANRE Q5I0F7_DANRE --------------DACASGDITGASKPASVTEGDPSSAAALPAIETNASANDKD----- FOXO6_HUMAN FOXO6_HUMAN -----------GAGVAEGAEDCGPER---------------------------------- FOXO6_MOUSE FOXO6_MOUSE -----------GAGVAEGSEDCGPER---------------------------------- Q5RJI9_MOUSE Q5RJI9_MOUSE -----------GAGVAEGSEDCGPER---------------------------------- Q4T8Y3_TETNG Q4T8Y3_TETNG ------------------------------------------------------------ A5PF57_DANRE A5PF57_DANRE ---------------CRSGGAPTEFKHPAGAP---------------------------- B4F6Q7_DANRE B4F6Q7_DANRE ---------------CRSGGAPTEFKHPAGAP---------------------------- MATCH CONSENSUS ????????????????????????????????????????????????????????????

B3UYC2_BRAFL B3UYC2_BRAFL -----AAEPTAPVAAAPTTVDATSLQAELQAPQPKKSSRRNAWGNLSYADLITKAIQSSP Q4S8Z6_TETNG Q4S8Z6_TETNG -----QRPAPQLPPQQQVPPPGAA------PQRKSSSSRRNAWGNMSYADLITKAIESSP A3RK75_DANRE A3RK75_DANRE -----HPQQVPPLPAPASGSSPAA------AQRKSSSSRRNAWGNMSYADLITKAIESSP FOXO1_XENLA FOXO1_XENLA -----PSVPSALSPASSPSPLGAQ------QPRKSSSSRRNAWGNLSYADLISQAIESSP FOXO1_XENTR FOXO1_XENTR -----PSVPSALSPASSPSPLGAQ------QPRKSSSSRRNAWGNLSYADLISQAIESSP Q9W7F9_CHICK Q9W7F9_CHICK -----PVPPVPPAVAALSPGPVAG------QPRKSSSSRRNAWGNLSYADLITKAIESSP FOXO1_HUMAN FOXO1_HUMAN -----SQHPPVPP---AAAGPLAG------QPRKSSSSRRNAWGNLSYADLITKAIESSA FOXO1_SPETR FOXO1_SPETR -----SQHPPVPP----AAGPLAG------QPRKSSSSRRNAWGNLSYADLITKAIESSA A4L7N3_PIG A4L7N3_PIG -----SQHPPVPP---AAAGSLAG------QPRKSSSSRRNAWGNLSYADLITKAIESSA Q8MK69_PIG Q8MK69_PIG -----SQHPPVP---PAAAGSLAG------QPRKSSSSRRNAWGNLSYADLITKAIESSA Q9ES26_RAT Q9ES26_RAT ---------------------------------------------------------SSA Q9WVH5_MOUSE Q9WVH5_MOUSE -----SQPPPVPPSAAAAAGPLAG------QPRKTSSSRRNAWGNLSYADLITKAIESSA Q8BPP2_MOUSE Q8BPP2_MOUSE ------------------------------------------------------------ Q9JJW4_MOUSE Q9JJW4_MOUSE -----SQPPPVPPSAAAAAGPLAG------QPRKTSSSRRNAWGNLSYADLITKAIESSA FOXO1_MOUSE FOXO1_MOUSE -----SQPPPVPPSAAAAAGPLAG------QPRKTSSSRRNAWGNLSYADLITKAIESSA Q4RFQ3_TETNG Q4RFQ3_TETNG QQQH-QQVPLLSSSVTSSSSPAAV------AQRKSSSSRRNAWGNMSYADLITKAIESSP A3RK74_DANRE A3RK74_DANRE -----QQVPVLSSPVAAAAAAAAA------AQRKSSSSRRNAWGNMSYADLITKAIESSP B1AUT2_MOUSE B1AUT2_MOUSE ------------------------------------------------------AIESAP B1AUT3_MOUSE B1AUT3_MOUSE ------SRLPEPAGGPQPGILGAV------TGPRKGGSRRNAWGNQSYAELISQAIESAP FOXO4_MOUSE FOXO4_MOUSE ------SRLPEPAGGPQPGILGAV------TGPRKGGSRRNAWGNQSYAELISQAIESAP A6QLP0_BOVIN A6QLP0_BOVIN -----PARLPDSAGGPQPGILGAV------TGPRKGGSRRNAWGNQSYAELISQAIESAP B4DTB6_HUMAN B4DTB6_HUMAN ------SRLPEPAGGPQPGILGAV------TGPRKGGSRRNAWGNQSYAELISQAIESAP A6NID2_HUMAN A6NID2_HUMAN ------SRLPEPAGGPQPGILGAV------TGPRKGGSRRNAWGNQSYAELISQAIESAP A8MXF0_HUMAN A8MXF0_HUMAN ------------------------------------------------------AIESAP FOXO4_HUMAN FOXO4_HUMAN ------SRLPEPAGGPQPGILGAV------TGPRKGGSRRNAWGNQSYAELISQAIESAP B7WPJ7_HUMAN B7WPJ7_HUMAN ------------------------------------------------------AIESAP B3DGQ4_DANRE B3DGQ4_DANRE -----LSSQAASATTASPEVASQH------QTPRKSSSRRNAWGNLSYADLITKAIESTP Q5TYS1_DANRE Q5TYS1_DANRE -----LSSQAASATTASPEVASQQ------QTPRKSSSRRNAWGNLSYADLITKAIESTP Q9W7F8_DANRE Q9W7F8_DANRE -----LSSQAASATTASPEVASQQ------QTPRKSSSRRNAWGNLSYADLITKAIESTP B4E1P9_HUMAN B4E1P9_HUMAN ------------------------------------------------------------ Q9WVH4_MOUSE Q9WVH4_MOUSE GGTPTQLQPQQPLPQPQPGAAGGS------GQPRKCSSRRNAWGNLSYADLITRAIESSP FOXO3_HUMAN FOXO3_HUMAN GGTQALLQPQQPLPPPQPGAAGGS------GQPRKCSSRRNAWGNLSYADLITRAIESSP B4DVZ6_HUMAN B4DVZ6_HUMAN ------------------------------------------------------------ Q68DV3_HUMAN Q68DV3_HUMAN ------------------------------------------------------------ A2A1E7_PIG A2A1E7_PIG ------------------------------------------------------------ B5UA80_PIG B5UA80_PIG GGTQTPLQPQQPLPPPQPGAAGGS------GQPRKCSSRRNAWGNLSYADLITRAIESSP Q1A729_PIG Q1A729_PIG ------------------------------------------------------------ A4IIM7_XENTR A4IIM7_XENTR -----VETLQASLGGGGAGGAQSGATG---QQQRKCSSRRNAWGNMSYADLITRAIESSQ B7ZS63_XENLA B7ZS63_XENLA -----VETLQVSLGGEGAGGAVSGAGGGGQQQQRKCSSRRNAWGNMSYADLITRAIESTQ FOXO3_XENLA FOXO3_XENLA -----VETLQVSLGGEGAGGAVSGAGGQ--QQQRKCSSRRNAWGNMSYADLITRAIESTQ Q4SV53_TETNG Q4SV53_TETNG ------------------------------------------------------------ Q90YK2_XIPMA Q90YK2_XIPMA -----THSPTATSGALTPSGLPAA------QTPRKASSRRNAWGNLSYADLITKAIESSP Q4REI0_TETNG Q4REI0_TETNG -----------------ALSASAS------QQLRKSSARRNAWGNYSYADLITQAIESSP Q5I0F7_DANRE Q5I0F7_DANRE -----IYGSPGSSQHALAACSDSSINGLIPQQPRKSSARRNAWGNYSYADLITQAIESSP FOXO6_HUMAN FOXO6_HUMAN -----RATAPAMAPAPPLGAEVG-------PLRKAKSSRRNAWGNLSYADLITKAIESAP FOXO6_MOUSE FOXO6_MOUSE -----RATAPAMAPAPPLGAEVG-------PLRKAKSSRRNAWGNLSYADLITKAIESAP Q5RJI9_MOUSE Q5RJI9_MOUSE -----RATAPAMAPAPPLGAEVG-------PLRKAKSSRRNAWGNLSYADLITKAIESAP Q4T8Y3_TETNG Q4T8Y3_TETNG ------------------------------------------------------------ A5PF57_DANRE A5PF57_DANRE -----APIAAAPACMSGAALDVAG------QLRKSKSSRRNAWGNQSYADLITRAIESTP B4F6Q7_DANRE B4F6Q7_DANRE -----APIAAAPACMSGAALDVAG------QLRKSKSSRRNAWGNQSYADLITRAIESTP MATCH CONSENSUS ??????????????????????????????????????????????????????AIES??

B3UYC2_BRAFL B3UYC2_BRAFL EGRLTLSQIYDWMVRCVPYFRDKGDSNSSAGWK--------------------------- Q4S8Z6_TETNG Q4S8Z6_TETNG EKRLTLSQIYDWMVKSVPYFKDKGDSNSSAGWK--------------------------- A3RK75_DANRE A3RK75_DANRE EKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWK--------------------------- FOXO1_XENLA FOXO1_XENLA EKRLTLSQIYDWMVKSVPYFKDKGDSNSSAGWK--------------------------- FOXO1_XENTR FOXO1_XENTR EKRLTLSQIYDWMVKSVPYFKDKGDSNSSAGWK--------------------------- Q9W7F9_CHICK Q9W7F9_CHICK EKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWK--------------------------- FOXO1_HUMAN FOXO1_HUMAN EKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWK--------------------------- FOXO1_SPETR FOXO1_SPETR EKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWK--------------------------- A4L7N3_PIG A4L7N3_PIG EKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWK--------------------------- Q8MK69_PIG Q8MK69_PIG EKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWK--------------------------- Q9ES26_RAT Q9ES26_RAT EKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWK--------------------------- Q9WVH5_MOUSE Q9WVH5_MOUSE EKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWK--------------------------- Q8BPP2_MOUSE Q8BPP2_MOUSE ------------------------------------------------------------ Q9JJW4_MOUSE Q9JJW4_MOUSE EKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWK--------------------------- FOXO1_MOUSE FOXO1_MOUSE EKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWK--------------------------- Q4RFQ3_TETNG Q4RFQ3_TETNG ENRLTLSQIYDWMVKSVPYFKDKGDSNSSAGWKTVVPGGTALEKLSEWTGPWPWHRTLPN A3RK74_DANRE A3RK74_DANRE EKRLTLSQIYDWMVKSVPYFKDKGDSNSSAGWK--------------------------- B1AUT2_MOUSE B1AUT2_MOUSE EKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWK--------------------------- B1AUT3_MOUSE B1AUT3_MOUSE EKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWK--------------------------- FOXO4_MOUSE FOXO4_MOUSE EKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWK--------------------------- A6QLP0_BOVIN A6QLP0_BOVIN EKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWK--------------------------- B4DTB6_HUMAN B4DTB6_HUMAN EKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWK--------------------------- A6NID2_HUMAN A6NID2_HUMAN EKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWK--------------------------- A8MXF0_HUMAN A8MXF0_HUMAN EKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWK--------------------------- FOXO4_HUMAN FOXO4_HUMAN EKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWK--------------------------- B7WPJ7_HUMAN B7WPJ7_HUMAN EKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWK--------------------------- B3DGQ4_DANRE B3DGQ4_DANRE DKRLTLSQIYDWMVSSVPYFKDKGDSNSSAGWK--------------------------- Q5TYS1_DANRE Q5TYS1_DANRE DKRLTLSQIYDWMVSSVPYFKDKGDSNSSAGWK--------------------------- Q9W7F8_DANRE Q9W7F8_DANRE DKRLTLSQIYDWMVSSVPYFKDKGDSNSSAGWK--------------------------- B4E1P9_HUMAN B4E1P9_HUMAN ------------------------------------------------------------ Q9WVH4_MOUSE Q9WVH4_MOUSE DKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWK--------------------------- FOXO3_HUMAN FOXO3_HUMAN DKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWK--------------------------- B4DVZ6_HUMAN B4DVZ6_HUMAN ------------------------------------------------------------ Q68DV3_HUMAN Q68DV3_HUMAN ------------------------------------------------------------ A2A1E7_PIG A2A1E7_PIG ------------------------------------------------------------ B5UA80_PIG B5UA80_PIG DKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWK--------------------------- Q1A729_PIG Q1A729_PIG ------------------------------------------------------------ A4IIM7_XENTR A4IIM7_XENTR DKRLTLSQIYDWMVRSVPYFKDKGDSNSSAGWK--------------------------- B7ZS63_XENLA B7ZS63_XENLA DKRLTLSQIYDWMVRSVPYFKDKGDSNSSAGWK--------------------------- FOXO3_XENLA FOXO3_XENLA DKRLTLSQIYDWMVRSVPYFKDKGDSNSSAGWK--------------------------- Q4SV53_TETNG Q4SV53_TETNG -------------------------------FQ--------------------------- Q90YK2_XIPMA Q90YK2_XIPMA EKRLTLSQIYDWMVRSIPYFKDKGDSNSSAGWK--------------------------- Q4REI0_TETNG Q4REI0_TETNG EKRLTLSQIYDWMVRSVPYFKDKGDSNSSAGWK--------------------------- Q5I0F7_DANRE Q5I0F7_DANRE EKRLTLAQIYDWMVRNVPYFKDKGDSNSSAGWK--------------------------- FOXO6_HUMAN FOXO6_HUMAN DKRLTLSQIYDWMVRYVPYFKDKGDSNSSAGWK--------------------------- FOXO6_MOUSE FOXO6_MOUSE DKRLTLSQIYDWMVRYVPYFKDKGDSNSSAGWK--------------------------- Q5RJI9_MOUSE Q5RJI9_MOUSE DKRLTLSQIYDWMVRYVPYFKDKGDSNSSAGWK--------------------------- Q4T8Y3_TETNG Q4T8Y3_TETNG --------------------------------Q--------------------------- A5PF57_DANRE A5PF57_DANRE EKRLTLSQIYDWMVRFVPYFKDKGDSNSSAGWK--------------------------- B4F6Q7_DANRE B4F6Q7_DANRE EKRLTLSQIYDWMVRFVPYFKDKGDSNSSAGWK--------------------------- MATCH CONSENSUS ?KRLTL?QIY?WMV??VPYFKDKGDSNSSAGWK???????????????????????????

B3UYC2_BRAFL B3UYC2_BRAFL ------------------------------------------------------------ Q4S8Z6_TETNG Q4S8Z6_TETNG -------------------------SGFLSSPSGAARCCVSEEMAQRQQMSSRSLLKSGK A3RK75_DANRE A3RK75_DANRE ------------------------------------------------------------ FOXO1_XENLA FOXO1_XENLA ------------------------------------------------------------ FOXO1_XENTR FOXO1_XENTR ------------------------------------------------------------ Q9W7F9_CHICK Q9W7F9_CHICK ------------------------------------------------------------ FOXO1_HUMAN FOXO1_HUMAN ------------------------------------------------------------ FOXO1_SPETR FOXO1_SPETR ------------------------------------------------------------ A4L7N3_PIG A4L7N3_PIG ------------------------------------------------------------ Q8MK69_PIG Q8MK69_PIG ------------------------------------------------------------ Q9ES26_RAT Q9ES26_RAT ------------------------------------------------------------ Q9WVH5_MOUSE Q9WVH5_MOUSE ------------------------------------------------------------ Q8BPP2_MOUSE Q8BPP2_MOUSE ------------------------------------------------------------ Q9JJW4_MOUSE Q9JJW4_MOUSE ------------------------------------------------------------ FOXO1_MOUSE FOXO1_MOUSE ------------------------------------------------------------ Q4RFQ3_TETNG Q4RFQ3_TETNG GKRSRWRRLCISKPPCRGEELEEPSSPSAPTSCLAPPASPILVLRKGRPVLLASQEFWGN A3RK74_DANRE A3RK74_DANRE ------------------------------------------------------------ B1AUT2_MOUSE B1AUT2_MOUSE ------------------------------------------------------------ B1AUT3_MOUSE B1AUT3_MOUSE ------------------------------------------------------------ FOXO4_MOUSE FOXO4_MOUSE ------------------------------------------------------------ A6QLP0_BOVIN A6QLP0_BOVIN ------------------------------------------------------------ B4DTB6_HUMAN B4DTB6_HUMAN ------------------------------------------------------------ A6NID2_HUMAN A6NID2_HUMAN ------------------------------------------------------------ A8MXF0_HUMAN A8MXF0_HUMAN ------------------------------------------------------------ FOXO4_HUMAN FOXO4_HUMAN ------------------------------------------------------------ B7WPJ7_HUMAN B7WPJ7_HUMAN ------------------------------------------------------------ B3DGQ4_DANRE B3DGQ4_DANRE ------------------------------------------------------------ Q5TYS1_DANRE Q5TYS1_DANRE ------------------------------------------------------------ Q9W7F8_DANRE Q9W7F8_DANRE ------------------------------------------------------------ B4E1P9_HUMAN B4E1P9_HUMAN ------------------------------------------------------------ Q9WVH4_MOUSE Q9WVH4_MOUSE ------------------------------------------------------------ FOXO3_HUMAN FOXO3_HUMAN ------------------------------------------------------------ B4DVZ6_HUMAN B4DVZ6_HUMAN ------------------------------------------------------------ Q68DV3_HUMAN Q68DV3_HUMAN ------------------------------------------------------------ A2A1E7_PIG A2A1E7_PIG ------------------------------------------------------------ B5UA80_PIG B5UA80_PIG ------------------------------------------------------------ Q1A729_PIG Q1A729_PIG ------------------------------------------------------------ A4IIM7_XENTR A4IIM7_XENTR ------------------------------------------------------------ B7ZS63_XENLA B7ZS63_XENLA ------------------------------------------------------------ FOXO3_XENLA FOXO3_XENLA ------------------------------------------------------------ Q4SV53_TETNG Q4SV53_TETNG ------------------------------------------------------------ Q90YK2_XIPMA Q90YK2_XIPMA ------------------------------------------------------------ Q4REI0_TETNG Q4REI0_TETNG ------------------------------------------------------------ Q5I0F7_DANRE Q5I0F7_DANRE ------------------------------------------------------------ FOXO6_HUMAN FOXO6_HUMAN ------------------------------------------------------------ FOXO6_MOUSE FOXO6_MOUSE ------------------------------------------------------------ Q5RJI9_MOUSE Q5RJI9_MOUSE ------------------------------------------------------------ Q4T8Y3_TETNG Q4T8Y3_TETNG ------------------------------------------------------------ A5PF57_DANRE A5PF57_DANRE ------------------------------------------------------------ B4F6Q7_DANRE B4F6Q7_DANRE ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

B3UYC2_BRAFL B3UYC2_BRAFL -NSIRHNLSLHSRFIRVQNEGTGKSSWWMLNPD-AKGGKSPRRRASSMDTNNSKYEKK-R Q4S8Z6_TETNG Q4S8Z6_TETNG KNSIRHNLSLHSRFVRIQNEGTGKSSWWMLNPEGGKNGKSPRRRAASMD-NNSKLARS-R A3RK75_DANRE A3RK75_DANRE -NSIRHNLSLHSRFVRVQNEGTGKSSWWMLNPEGGKSGKSPRRRATSMD-NNSKFTKS-R FOXO1_XENLA FOXO1_XENLA -NSIRHNLSLHSKFVRVQNEGTGKSSWWILNPEGGKNGKSPRRRAASMD-NNSKFAKS-R FOXO1_XENTR FOXO1_XENTR -NSIRHNLSLHSKFVRVQNEGTGKSSWWILNPEGGKNGKSPRRRAASMD-NNSKFAKS-R Q9W7F9_CHICK Q9W7F9_CHICK -NSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASMD-NNSKFAKS-R FOXO1_HUMAN FOXO1_HUMAN -NSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASMD-NNSKFAKS-R FOXO1_SPETR FOXO1_SPETR -NSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASMD-NNSKFAKS-R A4L7N3_PIG A4L7N3_PIG -NSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASMD-NNSKFAKS-R Q8MK69_PIG Q8MK69_PIG -NSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASMD-NNSKFAKS-R Q9ES26_RAT Q9ES26_RAT -NSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASMD-NNSKFAKS-R Q9WVH5_MOUSE Q9WVH5_MOUSE -NSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASMD-NNSKFAKS-R Q8BPP2_MOUSE Q8BPP2_MOUSE ------------------------------------------------------------ Q9JJW4_MOUSE Q9JJW4_MOUSE -NSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASMD-NNSKFAKS-R FOXO1_MOUSE FOXO1_MOUSE -NSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASMD-NNSKFAKS-R Q4RFQ3_TETNG Q4RFQ3_TETNG RNSIRHNLSLHSRFVRVQNEGTGKSSWWMLNPEGGKNGKSPRRRAASMD-NNSKFTKS-R A3RK74_DANRE A3RK74_DANRE -NSIRHNLSLHSRFIRVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASMD-NNSKFAKS-R B1AUT2_MOUSE B1AUT2_MOUSE -NSIRHNLSLHSKFIKVHNEATGKSSWWMLNPDGGKGGKAPRRRAASMD-SSSKLLRG-R B1AUT3_MOUSE B1AUT3_MOUSE -NSIRHNLSLHSKFIKVHNEATGKSSWWMLNPDGGKGGKAPRRRAASMD-SSSKLLRG-R FOXO4_MOUSE FOXO4_MOUSE -NSIRHNLSLHSKFIKVHNEATGKSSWWMLNPDGGKGGKAPRRRAASMD-SSSKLLRG-R A6QLP0_BOVIN A6QLP0_BOVIN -NSIRHNLSLHSKFIKVHNEATGKSSWWMLNPEGGKSGKAPRRRAASMD-SSSRLLRG-R B4DTB6_HUMAN B4DTB6_HUMAN -NSIRHNLSLHSKFIKVHNEATGKSSWWMLNPEGGKSGKAPRRRAASMD-SSSKLLRG-R A6NID2_HUMAN A6NID2_HUMAN -NSIRHNLSLHSKFIKVHNEATGKSSWWMLNPEGGKSGKAPRRRAASMD-SSSKLLRG-R A8MXF0_HUMAN A8MXF0_HUMAN -NSIRHNLSLHSKFIKVHNEATGKSSWWMLNPEGGKSGKAPRRRAASMD-SSSKLLRG-R FOXO4_HUMAN FOXO4_HUMAN -NSIRHNLSLHSKFIKVHNEATGKSSWWMLNPEGGKSGKAPRRRAASMD-SSSKLLRG-R B7WPJ7_HUMAN B7WPJ7_HUMAN -NSIRHNLSLHSKFIKVHNEATGKSSWWMLNPEGGKSGKAPRRRAASMD-SSSKLLRG-R B3DGQ4_DANRE B3DGQ4_DANRE -NSIRHNLSLHSRFIRVQNEGTGKSSWWMINPEGGRGGKAPRRRAVSMD-NGNKYTKTAR Q5TYS1_DANRE Q5TYS1_DANRE -NSIRHNLSLHSRFIRVQNEGTGKSSWWMINPEGGRGGKAPRRRAVSMD-NGNKYTKTAR Q9W7F8_DANRE Q9W7F8_DANRE -NSIRHNLSLHSRFIRVQNEGTGKSSWWMINPEGGRGGKAPRRRAVSMD-NGNKYTKTAR B4E1P9_HUMAN B4E1P9_HUMAN --------------MRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMD-NSNKYTKS-R Q9WVH4_MOUSE Q9WVH4_MOUSE -NSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMD-NSNKYTKS-R FOXO3_HUMAN FOXO3_HUMAN -NSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMD-NSNKYTKS-R B4DVZ6_HUMAN B4DVZ6_HUMAN --------------MRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMD-NSNKYTKS-R Q68DV3_HUMAN Q68DV3_HUMAN --------------MRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMD-NSNKYTKS-R A2A1E7_PIG A2A1E7_PIG ----------------------------------------PRRRAVSMD-NSNKYTKS-R B5UA80_PIG B5UA80_PIG -NSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMD-NSNKYTKS-R Q1A729_PIG Q1A729_PIG ------------------------------------------------------------ A4IIM7_XENTR A4IIM7_XENTR -NSIRHNLSLHSRFIRVQNEGSGKSSWWMINPEGGKGGKAPRRRAVSMD-NSNKYTKS-R B7ZS63_XENLA B7ZS63_XENLA -NSIRHNLSLHSRFIRVQNEGSGKSSWWMINPEGGKGGKAPRRRAVSMD-NSNKYTKS-R FOXO3_XENLA FOXO3_XENLA -NSIRHNLSLHSRFIRVQNEGSGKSSWWMINPEGGKGGKAPRRRAVSMD-NSNKYTKS-R Q4SV53_TETNG Q4SV53_TETNG -NSIRHNLSLHSRFIRVQNEGTGKSSWWMINPEGGRGGKAPRRRAVSMD-NSNKYIKSAR Q90YK2_XIPMA Q90YK2_XIPMA -NSIRHNLSLHSRFIRVQNEGTGKSSWWMINPEGGKGGKAPRRRAVSMD-NSNKYTKSAR Q4REI0_TETNG Q4REI0_TETNG -NSIRHNLSLHSRFVKVQNEGTGKSSWWMVNPEGGKGGKAPRRRAVSMD--NSKYIKGAR Q5I0F7_DANRE Q5I0F7_DANRE -NSIRHNLSLHSRFVRVQNEGTGKSSWWMVNPDGGKGGKAPRRRAVSMD-NSNKLIKSAR FOXO6_HUMAN FOXO6_HUMAN -NSIRHNLSLHTRFIRVQNEGTGKSSWWMLNPEGGKTGKTPRRRAVSMD-NGAKFLRI-K FOXO6_MOUSE FOXO6_MOUSE -NSIRHNLSLHTRFIRVQNEGTGKSSWWMLNPEGGKTGKTPRRRAVSMD-NGAKFLRI-K Q5RJI9_MOUSE Q5RJI9_MOUSE -NSIRHNLSLHTRFIRVQNEGTGKSSWWMLNPEGGKTGKTPRRRAVSMD-NGAKFLRI-K Q4T8Y3_TETNG Q4T8Y3_TETNG -NSIRHNLSLHTRFIRVQNEGTGKSSWWMLNPDGGKMGKAPRRRAVSMD-SNTKYLKS-K A5PF57_DANRE A5PF57_DANRE -NSIRHNLSLHTRFIRVQNEGTGKSSWWMLNPEGGKMGKGPRRRAVSMD-NGTKYLKS-R B4F6Q7_DANRE B4F6Q7_DANRE -NSIRHNLSLHTRFIRVQNEGTGKSSWWMLNPEGGKMGKGPRRRAVSMD-NGTKYLKS-R MATCH CONSENSUS ?NSIRHNLSLH??F??V?NE?TGKSSWW??NP?GGK?GK?PRRRA?SMD????K?????R

B3UYC2_BRAFL B3UYC2_BRAFL GRAKKKAQE---------AREAAAAANASSPTGKW----PGSPQDSKSEGGTPSGDGNLS Q4S8Z6_TETNG Q4S8Z6_TETNG GRATKKKM-ALQE-----AVEGGTSS-PGSHYSNW----LGSPNSHSNK----------- A3RK75_DANRE A3RK75_DANRE GRAAKKKM-SLQG-----GLDGGSNS-PGSQYPKW----LGSPNSHSND----------- FOXO1_XENLA FOXO1_XENLA GRAAKKKA-SMQS-----SQDGSSDS-PGSQFSKW----PGSPSSQSND----------- FOXO1_XENTR FOXO1_XENTR GRAAKKKA-TMQS-----SQDGSSDS-PGSQFSKW----PGSPSSQSND----------- Q9W7F9_CHICK Q9W7F9_CHICK GRAAKKKA-SLQS-----GQEGNGDS-PGSQFSKW----PASPSSHSND----------- FOXO1_HUMAN FOXO1_HUMAN SRAAKKKA-SLQS-----GQEGAGDS-PGSQFSKW----PASPGSHSND----------- FOXO1_SPETR FOXO1_SPETR GQAAKKKA-SLQS-----GQEGAGDS-PGSQFSKW----PASPGSHSND----------- A4L7N3_PIG A4L7N3_PIG GRAAKKKA-SLQS-----GQEGAGDS-PGSQFSKW----PASPGSHSND----------- Q8MK69_PIG Q8MK69_PIG GRAAKKKA-SLQS-----GQEGAGDS-PGSQFSKW----PASPGSHSND----------- Q9ES26_RAT Q9ES26_RAT GRAAKKKA-SLQS-----GQEGPGDS-PGSQFSKW----PASPGSHSND----------- Q9WVH5_MOUSE Q9WVH5_MOUSE GRAAKKKA-SLQS-----GQEGPGDS-PGSQFSKW----PASPGSHSND----------- Q8BPP2_MOUSE Q8BPP2_MOUSE ---------------------GPGDS-PGSQFSKW----PASPGSHSND----------- Q9JJW4_MOUSE Q9JJW4_MOUSE GRAAKKKA-SLQS-----GQEGPGDS-PGSQFSKW----PASPGSHSND----------- FOXO1_MOUSE FOXO1_MOUSE GRAAKKKA-SLQS-----GQEGPGDS-PGSQFSKW----PASPGSHSND----------- Q4RFQ3_TETNG Q4RFQ3_TETNG GRAAKKKL-ALQG-----GPDGGGD--SPGSYSKW----PGSPNSHSND----------- A3RK74_DANRE A3RK74_DANRE GRAAKKKL-ALQG-----GPEGGADS-PGSQYGKW----PGSPNSHSND----------- B1AUT2_MOUSE B1AUT2_MOUSE SKGPKKKPSVLPA-----PPEGATPRSPLGHFAKW----SSSPCPRNRE----------- B1AUT3_MOUSE B1AUT3_MOUSE SKGPKKKPSVLPA-----PPEGATPRSPLGHFAKW----SSSPCPRNRE----------- FOXO4_MOUSE FOXO4_MOUSE SKGPKKKPSVLPA-----PPEGATPRSPLGHFAKW----SSSPCPRNRE----------- A6QLP0_BOVIN A6QLP0_BOVIN SKTPKKKPAVLPA-----PREGATPRSPAGHFAKW----SGSPCSRNRE----------- B4DTB6_HUMAN B4DTB6_HUMAN SKAPKKKPSVLPA-----PPEGATPTSPVGHFAKW----SGSPCSRNRE----------- A6NID2_HUMAN A6NID2_HUMAN SKAPKKKPSVLPA-----PPEGATPTSPVGHFAKW----SGSPCSRNRE----------- A8MXF0_HUMAN A8MXF0_HUMAN SKAPKKKPSVLPA-----PPEGATPTSPVGHFAKW----SGSPCSRNRE----------- FOXO4_HUMAN FOXO4_HUMAN SKAPKKKPSVLPA-----PPEGATPTSPVGHFAKW----SGSPCSRNRE----------- B7WPJ7_HUMAN B7WPJ7_HUMAN SKAPKKKPSVLPA-----PPEGATPTSPVGHFAKW----SGSPCSRNRE----------- B3DGQ4_DANRE B3DGQ4_DANRE GRAAKKKA-ALQA-----AQEGSLENISAGGLSKW----PGSPTSRSSD----------- Q5TYS1_DANRE Q5TYS1_DANRE GRAAKKKA-ALQA-----AQEGSLENISAGGLSKW----PGSPTSRSSD----------- Q9W7F8_DANRE Q9W7F8_DANRE GRAAKKKA-ALQA-----AQEGSLENISAGGLSKW----PGSPTSRSSD----------- B4E1P9_HUMAN B4E1P9_HUMAN GRAAKKKA-ALQT-----APESADD--SPSQLSKW----PGSPTSRSSD----------- Q9WVH4_MOUSE Q9WVH4_MOUSE GRAAKKKA-ALQA-----APESADD--SPSQLSKW----PGSPTSRSSD----------- FOXO3_HUMAN FOXO3_HUMAN GRAAKKKA-ALQT-----APESADD--SPSQLSKW----PGSPTSRSSD----------- B4DVZ6_HUMAN B4DVZ6_HUMAN GRAAKKKA-ALQT-----APESADD--SPSQLSKW----PGSPTSRSSD----------- Q68DV3_HUMAN Q68DV3_HUMAN GRAAKKKA-ALQT-----APESADD--SPSQLSKW----PGSPTSRSSD----------- A2A1E7_PIG A2A1E7_PIG GRAAKKKA-ALQT-----APESADD--SPSQLSKW----PGSPTSRSSD----------- B5UA80_PIG B5UA80_PIG GRAAKKKA-ALQT-----APESADD--SPSQLSKW----PGSPTSRSSD----------- Q1A729_PIG Q1A729_PIG -----------------------DD--SPSQLSKW----PGSPTSRSSD----------- A4IIM7_XENTR A4IIM7_XENTR GRAAKKKA-SLQA-----STDATDD--SPSQLSKW----PGSPTSRSSD----------- B7ZS63_XENLA B7ZS63_XENLA GRAAKKKA-SLQA-----SSDATDD--SPSQLSKW----PGSPTSRSSD----------- FOXO3_XENLA FOXO3_XENLA GRAAKKKA-SLQA-----SSDATDD--SPSQLSKW----PGSPTSRSSD----------- Q4SV53_TETNG Q4SV53_TETNG GETAKKKA-VLQA--SAAAGDAGGD--SPSGPSKW----PGSPTSRSSE----------- Q90YK2_XIPMA Q90YK2_XIPMA GRAAAKKKAALQA-VAAAAGEGGGD--SPTGPSKW----PGSPTSRSSE----------- Q4REI0_TETNG Q4REI0_TETNG GRATKKKA-LLQA-----AQDGSSE--SSSSLSKW----TGSPTSRSSD----------- Q5I0F7_DANRE Q5I0F7_DANRE GRAAKKKA-ALQA-----SQDGSSE--SSSSLSKW----TGSPTSRSSD----------- FOXO6_HUMAN FOXO6_HUMAN GKASKKKQLQAPERSPDDSSPSAPAPGPVPAAAKW----AASPASHASD----------- FOXO6_MOUSE FOXO6_MOUSE GKASKKKQLHLPERSPDDSPPGAPVPGPLSASAKW----AASPASHASD----------- Q5RJI9_MOUSE Q5RJI9_MOUSE GKASKKKQLHLPERSPDDSPPGAPVPGPLSASAKW----AASPASHASD----------- Q4T8Y3_TETNG Q4T8Y3_TETNG GRIRGKRA-GRPALGPGSAVMGLQSPPDVSSSPQKGLSGPGGASGTDGD----------- A5PF57_DANRE A5PF57_DANRE GRVSRKRT-AAVGMGRELGAPGIQGSPEHGSPAGK------GVMGIGSE----------- B4F6Q7_DANRE B4F6Q7_DANRE GRVSRKRT-AAVGMGRELGAPGIQGSPEHGSPAGK------GVMGIGSE----------- MATCH . . CONSENSUS ??A?KKK???L??????????????????????KW??????SP?S???????????????

B3UYC2_BRAFL B3UYC2_BRAFL VSTASPLSFNI--SDFRQRTSSNASSLSGRLSPIMG-PDLDDDNQVP------PMSPG-W Q4S8Z6_TETNG Q4S8Z6_TETNG -------DFEA-WSSFRTRASSDASTLSGRHSPFS--SEHDDLGESE--------GHMIY A3RK75_DANRE A3RK75_DANRE -------DFEP-WGNFRTRASSDASTLSGRRSPFL--PEEDEAAEVH----------IGY FOXO1_XENLA FOXO1_XENLA -------DFEA-WSTFRPRTSSNASTISGRLSPIM--PEQDDLGDAD-------VHNLVY FOXO1_XENTR FOXO1_XENTR -------DFEA-WSTFRPRTSSNASTISGRLSPIM--PEQDDLGDAD-------VHNLVY Q9W7F9_CHICK Q9W7F9_CHICK -------DFDN-WSTFRPRTSSNASTISGRLSPIL--PEQDDLGDGD-------VHSMVY FOXO1_HUMAN FOXO1_HUMAN -------DFDN-WSTFRPRTSSNASTISGRLSPIM--TEQDDLGEGD-------VHSMVY FOXO1_SPETR FOXO1_SPETR -------DFDN-WSTFRPRTSSNASTISGRFSPIM--TEQDDLGDGD-------VHSLVY A4L7N3_PIG A4L7N3_PIG -------DFDN-WSTFRPRTSSNASTISGRLSPIM--TEQDDLGNGD-------VHSMVY Q8MK69_PIG Q8MK69_PIG -------DFDN-WSTFRPRTSSNASTISGRLSPIM--TEQDDLGNGD-------VHSMVY Q9ES26_RAT Q9ES26_RAT -------DFDN-WSTFRPRTSSNASTISGRLSPIM--TEQDDLGDGD-------VHSLVY Q9WVH5_MOUSE Q9WVH5_MOUSE -------DFDN-WSTFRPRTSSNASTISGRLSPIM--TEQDDLGDGD-------VHSLVY Q8BPP2_MOUSE Q8BPP2_MOUSE -------DFDN-WSTFRPRTSSNASTISGRLSPIM--TEQDDLGDGD-------VHSLVY Q9JJW4_MOUSE Q9JJW4_MOUSE -------DFDN-WSTFRPRTSSNASTISGRLSPIM--TEQDDLGDGD-------VHSLVY FOXO1_MOUSE FOXO1_MOUSE -------DFDN-WSTFRPRTSSNASTISGRLSPIM--TEQDDLGDGD-------VHSLVY Q4RFQ3_TETNG Q4RFQ3_TETNG -------DFDV-WNSFRPRTSSNASTLSGRLSPFM--PE-DDLGEAD--------VHMGY A3RK74_DANRE A3RK74_DANRE -------DFEA-WTAFRPRTSSNASTLSGRLSPFI----DDELGDSD--------VHMVY B1AUT2_MOUSE B1AUT2_MOUSE -------EADV-WTTFRPRSSSNASTVSTRLSPMR--PESEVLAEEE-----MPASASSY B1AUT3_MOUSE B1AUT3_MOUSE -------EADV-WTTFRPRSSSNASTVSTRLSPMR--PESEVLAEEE-----MPASASSY FOXO4_MOUSE FOXO4_MOUSE -------EADV-WTTFRPRSSSNASTVSTRLSPMR--PESEVLAEEE-----MPASASSY A6QLP0_BOVIN A6QLP0_BOVIN -------EADA-WSTFRPRSSSNASTVSTRPSPRE--PEPEVLAEEE-----MPASASGY B4DTB6_HUMAN B4DTB6_HUMAN -------EADM-WTTFRPRSSSNASSVSTRLSPLR--PESEVLAEEI------PASVSSY A6NID2_HUMAN A6NID2_HUMAN -------EADM-WTTFRPRSSSNASSVSTRLSPLR--PESEVLAEEI------PASVSSY A8MXF0_HUMAN A8MXF0_HUMAN -------EADM-WTTFRPRSSSNASSVSTRLSPLR--PESEVLAEEI------PASVSSY FOXO4_HUMAN FOXO4_HUMAN -------EADM-WTTFRPRSSSNASSVSTRLSPLR--PESEVLAEEI------PASVSSY B7WPJ7_HUMAN B7WPJ7_HUMAN -------EADM-WTTFRPRSSSNASSVSTRLSPLR--PESEVLAEEI------PASVSSY B3DGQ4_DANRE B3DGQ4_DANRE -------EQESCWTDFRSRTNSNASTVSGRLSPILANPELDDVSDGP------PLSPILY Q5TYS1_DANRE Q5TYS1_DANRE -------EQESCWTDFRSRTNSNASTVSGRLSPILANPELDDVSDGP------PLSPILY Q9W7F8_DANRE Q9W7F8_DANRE -------EQESCWTDFRSRTNSNASTVSGRLSPILANPELDDVSDGP------PLSPILY B4E1P9_HUMAN B4E1P9_HUMAN -------ELDA-WTDFRSRTNSNASTVSGRLSPIMASTELDEVQDDD-----APLSPMLY Q9WVH4_MOUSE Q9WVH4_MOUSE -------ELDA-WTDFRSRTNSNASTVSGRLSPILASTELDDVQDDD-----GPLSPMLY FOXO3_HUMAN FOXO3_HUMAN -------ELDA-WTDFRSRTNSNASTVSGRLSPIMASTELDEVQDDD-----APLSPMLY B4DVZ6_HUMAN B4DVZ6_HUMAN -------ELDA-WTDFRSRTNSNASTVSGRLSPIMASTELDEVQDDD-----APLSPMLY Q68DV3_HUMAN Q68DV3_HUMAN -------ELDA-WTDFRSRTNSNASTVSGRLSPIMASTELDEVQDDD-----APLSPMLY A2A1E7_PIG A2A1E7_PIG -------ELDA-WTDFRSRTNSNASTVSGRLSPILASTELDDVQDDD-----APLSPMLY B5UA80_PIG B5UA80_PIG -------ELDA-WTDFRSRTNSNASTVSGRLSPILASTELDDVQDDD-----APLSPMLY Q1A729_PIG Q1A729_PIG -------ELDA-WTDFRSRTNSNASTVSGRLSPILASTELDDVQDDD-----APLSPMLY A4IIM7_XENTR A4IIM7_XENTR -------ELDA-WTDFRSRTNSNASTISGRLSPIPATTELDDVQDDD-----SPLSPMLY B7ZS63_XENLA B7ZS63_XENLA -------ELDT-WTDFRSRTNSNASTISGRLSPIPATTELDDVQDDD-----SPLSPMLY FOXO3_XENLA FOXO3_XENLA -------KLDT-WTDFRSRTNSNASTISGRLSPIPATTELDDVQDDD-----SPLSPMLY Q4SV53_TETNG Q4SV53_TETNG -------EPDT-WTDFRSRTNSNASTLSGRLSPIMANPELNEAPDDE-----RPISPMLY Q90YK2_XIPMA Q90YK2_XIPMA -------ELDA-WTDFRSRTNSNASTLSGRLSPILANPELDEVADDE-----PPLSPMIY Q4REI0_TETNG Q4REI0_TETNG -------ELDA-WTDFRSRTNSNASTLSGRLSPILANLELDEVPDDD-----SPLSPMLY Q5I0F7_DANRE Q5I0F7_DANRE -------ELDA-WTDFRSRTNSNASTLSGRLSPILANLEVDEVPDDD-----SPLSPMLY FOXO6_HUMAN FOXO6_HUMAN -------DYEA-WADFR-----------GGGRPLL--GEAAELEDDEALEALAPSSPLMY FOXO6_MOUSE FOXO6_MOUSE -------DYEA-WADFR-----------GSRRPLL--GEAAELEDDEALEALAPSSPLMY Q5RJI9_MOUSE Q5RJI9_MOUSE -------DYEA-WADFR-----------GSRRPLL--GEAAELEDDEALEALAPSSPLMY Q4T8Y3_TETNG Q4T8Y3_TETNG --------FDT-WSDLHSRASSSASTLSGRLSPILAEGEPEKTEEGL----SCSTSPQLY A5PF57_DANRE A5PF57_DANRE -------EFDA-WTDLHSRTSSSASTLSGCLSPILAETEPDEPEEGG---LSCSASPRLY B4F6Q7_DANRE B4F6Q7_DANRE -------EFDA-WTDLHSRTSSSASTLSGCLSPILAETEPDEPEEGG---LSCSASPRLY MATCH : :: * : : CONSENSUS ????????????W??FR?R??SNAST?SGRLSP?????E????????????????????Y

B3UYC2_BRAFL B3UYC2_BRAFL SDFGSNSNLSY---------GTSDFLNQSTDQLTQSLQQTMKLNSPDQLLGDSGLSGMSS Q4S8Z6_TETNG Q4S8Z6_TETNG AG-VPGTKISS------------TLPSVSEVAGSIGQHG--SENVMGGLLDNLNLASPKP A3RK75_DANRE A3RK75_DANRE P----GTKLGG------------PLPSLSEVAGHHG-----SENMMDNLLENLNLISPKN FOXO1_XENLA FOXO1_XENLA P--SSATKLTS------------TLPSLSEMGN--------SEN-MENLLDNLNLLTPNS FOXO1_XENTR FOXO1_XENTR P--PSATKLTS------------TLPSLSEMGN--------SEN-MENLLDNLNLLSPNT Q9W7F9_CHICK Q9W7F9_CHICK P--SSATKMTS------------TLPSLSEMSS--------SEN-MENLLDNLNLLSPNT FOXO1_HUMAN FOXO1_HUMAN P--PSAAKMAS------------TLPSLSEISN--------PEN-MENLLDNLNLLSSPT FOXO1_SPETR FOXO1_SPETR P--PSASKMAS------------TLPSLSEISN--------PEN-MENLLDNLNLLSSPT A4L7N3_PIG A4L7N3_PIG P--PSAAKMAS------------TLPSLSEISN--------PEN-MENLLDNLNLLSSPT Q8MK69_PIG Q8MK69_PIG P--PSAAKMAS------------TLPSLSEISN--------PEN-MENLLDNLNLLSSPT Q9ES26_RAT Q9ES26_RAT P--PSAAKMAS------------TLPSLSEISN--------PEN-MENLLDNLNLLSSPT Q9WVH5_MOUSE Q9WVH5_MOUSE P--PSAAKMAS------------TLPSLSEISN--------PEN-MENLLDNLNLLSSPT Q8BPP2_MOUSE Q8BPP2_MOUSE P--PSAAKMAS------------TLPSLSEISN--------PEN-MENLLDNLNLLSSPT Q9JJW4_MOUSE Q9JJW4_MOUSE P--PSAAKMAS------------TLPSLSEISN--------PEN-MENLLDNLNLLSSPT FOXO1_MOUSE FOXO1_MOUSE P--PSAAKMAS------------TLPSLSEISN--------PEN-MENLLDNLNLLSSPT Q4RFQ3_TETNG Q4RFQ3_TETNG PG-APGSKMTA------------TLPSLTEMTGSLGRS---SENVMENLLDNLNLLSPNN A3RK74_DANRE A3RK74_DANRE PGPGSGTKMTS------------TLPSLSEMAGSLGHSG--SENVMENLLDNLNLLSPKN B1AUT2_MOUSE B1AUT2_MOUSE AG---GVPPTL------------------------------SEDL--ELLDGLNLAS--- B1AUT3_MOUSE B1AUT3_MOUSE AG---GVPPTL------------------------------SEDL--ELLDGLNLAS--- FOXO4_MOUSE FOXO4_MOUSE AG---GVPPTL------------------------------SEDL--ELLDGLNLAS--- A6QLP0_BOVIN A6QLP0_BOVIN AG---GVPPTL------------------------------KEDL--ELLDGLNLTS--- B4DTB6_HUMAN B4DTB6_HUMAN AG---GVPPTL------------------------------NEGL--ELLDGLNLTS--- A6NID2_HUMAN A6NID2_HUMAN AG---GVPPTL------------------------------NEGL--ELLDGLNLTS--- A8MXF0_HUMAN A8MXF0_HUMAN AG---GVPPTL------------------------------NEGL--ELLDGLNLTS--- FOXO4_HUMAN FOXO4_HUMAN AG---GVPPTL------------------------------NEGL--ELLDGLNLTS--- B7WPJ7_HUMAN B7WPJ7_HUMAN AG---GVPPTL------------------------------NEGL--ELLDGLNLTS--- B3DGQ4_DANRE B3DGQ4_DANRE SSPSSLSPPSSTSSNSKTCPG--ELPVLADLTGTMNLNE--ADNLMVDLLDNIAT----- Q5TYS1_DANRE Q5TYS1_DANRE SSPSSLSPPSSTSSNSKTCPG--ELPVLADLTGTMNLNE--ADNLMVDLLDNIAT----- Q9W7F8_DANRE Q9W7F8_DANRE SSPSSLSPPSSTSSNSKTCPG--ELPVLADLTGTMNLNE--ADNLMVDLLDNIAT----- B4E1P9_HUMAN B4E1P9_HUMAN SS-SASLSPSV----SKPCTV--ELPRLTDMAGTMNLNDGLTENLTDDLLDNITLPPSQP Q9WVH4_MOUSE Q9WVH4_MOUSE SS-SASLSPSV----SKPCTV--ELPRLTDMAGTMNLNDGLAENLMDDLLDNIALPPSQP FOXO3_HUMAN FOXO3_HUMAN SS-SASLSPSV----SKPCTV--ELPRLTDMAGTMNLNDGLTENLMDDLLDNITLPPSQP B4DVZ6_HUMAN B4DVZ6_HUMAN SS-SASLSPSV----SKPCTV--ELPRLTDMAGTMNLNDGLTENLMDDLLDNITLPPSQP Q68DV3_HUMAN Q68DV3_HUMAN SS-SASLSPSV----SRPCTV--ELPRLTDMAGTMNLNDGLTENLMDDLLDNITLPPSQP A2A1E7_PIG A2A1E7_PIG SS-SASLSPSV----SKPCTV--ELPRLTDMAGTMNLNDGLADNLMDDLLDNIALPSSQP B5UA80_PIG B5UA80_PIG SS-SASLSPSV----SKPCTV--ELPRLTDMAGTMNLNDGLADNLMDDLLDNIALPSSQP Q1A729_PIG Q1A729_PIG SS-SASLSPSV----SKPCTV--ELPRLTDMAGTMNLNDGLADNLMDDLLDNIALPSSQP A4IIM7_XENTR A4IIM7_XENTR SS-PGSLSPSL----SKPCTV--EMPRITDMAGTMNLNDGLPENLMDDLLDDISLTSSQQ B7ZS63_XENLA B7ZS63_XENLA NS-PGSLSPSI----SKPCTV--EMPRITDMAETMNLNDGLPENLMDDLLDDISLTSSQQ FOXO3_XENLA FOXO3_XENLA NS-PGSLSPSI----SKPCTV--EMPRITDMAETMNLNDGLPENLMDDLLDDISLTSSQQ Q4SV53_TETNG Q4SV53_TETNG SSPGRALSPGNAATNGKSAPA--ELPRLADLTGTMNLNDGLTDDLMDDLLENINLVPTVT Q90YK2_XIPMA Q90YK2_XIPMA SSPGRALSPGN--TNGKAVPT--ELPRLADLANTMNLNDGITQDLMDDFLDNIKLVPTTC Q4REI0_TETNG Q4REI0_TETNG SS-PSSMSPST------------GPTVLSDLAGTMNLNDGLSDNLMDDLLDNISL----- Q5I0F7_DANRE Q5I0F7_DANRE SS-PSSMSPST---------GLTELPRLADLAGTMNLNDGLSDNLMDDLLDNISLTASQS FOXO6_HUMAN FOXO6_HUMAN PSPASALSPAL----GSRCPG--ELPRLAELGGPLGLHGGGGAGLPEGLLDGA------- FOXO6_MOUSE FOXO6_MOUSE PSPASALSPAL----GARCPG--ELPRLAELGGPLGLHGGGVAGLPDALLDGAQDAY--- Q5RJI9_MOUSE Q5RJI9_MOUSE PSPASALSPAL----GARCPG--ELPRLAELGGPLGLHGGGVAGLPDALLDGAQDAY--- Q4T8Y3_TETNG Q4T8Y3_TETNG PSPTSARSPPV--VTGKNCPPFEQLPQLTNLTATISLDEHLNEDGYHHQ----------- A5PF57_DANRE A5PF57_DANRE PSPTSTRSPAL--GTGGHCPSV-ELPHLADLTGAISLEEGY------------------- B4F6Q7_DANRE B4F6Q7_DANRE PSPTSTRSPAL--GTGGHCPSV-ELPHLADLTGAISLEEGY------------------- MATCH CONSENSUS ????????????????????????????????????????????????LLD???L?????

B3UYC2_BRAFL B3UYC2_BRAFL MDSVGSLGLGGFDSQ--PDPFMRRCHSVGSRAQLPSPRRQNTGY--STPPPS-------- Q4S8Z6_TETNG Q4S8Z6_TETNG SQ-----LGSDSLHSS-NAAMLQSGP----YCS------TGLTL---HPQQD-------- A3RK75_DANRE A3RK75_DANRE NT-----QGSQEAQTALSSPLMQGSPGYPSYTS------PNMGP--QPQVQQD------- FOXO1_XENLA FOXO1_XENLA -----------STQSS-PASMMQQS-GYL-FTS------PNTSL--GSPNSE-------- FOXO1_XENTR FOXO1_XENTR -----------STQSS-PASMMQQS-GYL-FTS------PNTSL--GSPNSE-------- Q9W7F9_CHICK Q9W7F9_CHICK -------SMTVSTQSS-SAALMQQTPGYS-FAS------STTSI--CSPNPD-------- FOXO1_HUMAN FOXO1_HUMAN -------SLTVSTQSS-PGTMMQQTPCYS-FAP------PNTSL--NSPSPN-------- FOXO1_SPETR FOXO1_SPETR -------SLTVSTQSS-PGSMMQQTPCYS-FAP------PSTSL--NSPSPN-------- A4L7N3_PIG A4L7N3_PIG -------SLTVSTQSS-PGTIMQQTPCYS-FAP------PNTSL--NSPSPN-------- Q8MK69_PIG Q8MK69_PIG -------SLTVSTQSS-PGTIMQQTPCYS-FAP------PNTSL--NSPSPN-------- Q9ES26_RAT Q9ES26_RAT -------SLTVSTQSS-PGSMMQQTPCYS-FAP------PNTSL--NSPSPN-------- Q9WVH5_MOUSE Q9WVH5_MOUSE -------SLTVSTQSS-PGSMMQQTPCYS-FAP------PNTSL--NSPSPN-------- Q8BPP2_MOUSE Q8BPP2_MOUSE -------SLTVSTQSS-PGSMMQQTPCYS-FAP------PNTSL--NSPSPN-------- Q9JJW4_MOUSE Q9JJW4_MOUSE -------SLTVSTQSS-PGSMMQQTPCYS-FAP------PNTSL--NSPSPN-------- FOXO1_MOUSE FOXO1_MOUSE -------SLTVSTQSS-PGSMMQQTPCYS-FAP------PNTSL--NSPSPN-------- Q4RFQ3_TETNG Q4RFQ3_TETNG SQVGGGTKTPGSSQSS-PSPMMQPSPGYQAYSS------PSMV---SQPQQD-------- A3RK74_DANRE A3RK74_DANRE PSTGG--PGSGSNQSS-PSSLMQASPGYSPYSS------PGLSAVSQQTQQD-------- B1AUT2_MOUSE B1AUT2_MOUSE -----------------PHSLLSRSGLSG-FSL------QHPGL--AGPLHS-------- B1AUT3_MOUSE B1AUT3_MOUSE -----------------PHSLLSRSGLSG-FSL------QHPGL--AGPLHS-------- FOXO4_MOUSE FOXO4_MOUSE -----------------PHSLLSRSGLSG-FSL------QHPGL--AGPLHS-------- A6QLP0_BOVIN A6QLP0_BOVIN -----------------PHSLLSRSSLSG-FSL------QHPGV--PGPLHT-------- B4DTB6_HUMAN B4DTB6_HUMAN -----------------SHSLLSRSGLSG-FSL------QHPGV--TGPLHT-------- A6NID2_HUMAN A6NID2_HUMAN -----------------SHSLLSRSGLSG-FSL------QHPGV--TGPLHT-------- A8MXF0_HUMAN A8MXF0_HUMAN -----------------SHSLLSRSGLSG-FSL------QHPGV--TGPLHT-------- FOXO4_HUMAN FOXO4_HUMAN -----------------SHSLLSRSGLSG-FSL------QHPGV--TGPLHT-------- B7WPJ7_HUMAN B7WPJ7_HUMAN -----------------SHSLLSRSGLSG-FSL------QHPGV--TGPLHT-------- B3DGQ4_DANRE B3DGQ4_DANRE -----------------QVQVVQESSPFS-FGS------KSTAS--PPSTSTSQTVSNNT Q5TYS1_DANRE Q5TYS1_DANRE -----------------QVQVVQESSPFS-FGS------KSTAS--PPSTSTSQTVSNNT Q9W7F8_DANRE Q9W7F8_DANRE -----------------QVQVVQESSPFS-FGS------KSTAS--PPSTSTSQTVSNNT B4E1P9_HUMAN B4E1P9_HUMAN SP---------------TGGLMQRSSSFP-YTT------KGSGL--GSPTSS-------- Q9WVH4_MOUSE Q9WVH4_MOUSE SP---------------PGGLMQRGSSFP-YTA------KSSGL--GSPTGS-------- FOXO3_HUMAN FOXO3_HUMAN SP---------------TGGLMQRSSSFP-YTT------KGSGL--GSPTSS-------- B4DVZ6_HUMAN B4DVZ6_HUMAN SP---------------TGGLMQRSSSFP-YTT------KGSGL--GSPTSS-------- Q68DV3_HUMAN Q68DV3_HUMAN SP---------------TGGLMQRSSSFP-YTT------KGSGL--GSPTSS-------- A2A1E7_PIG A2A1E7_PIG SP---------------PGGLMQRSSSFP-YTT------KGSGL--GSPTSS-------- B5UA80_PIG B5UA80_PIG SP---------------PGGLMQRSSSFP-YTT------KGSGL--GSPTSS-------- Q1A729_PIG Q1A729_PIG SP---------------PGGLMQRSSSFP-YTT------KGSGL--GSPTSS-------- A4IIM7_XENTR A4IIM7_XENTR SS---------------PGILMQRSSSFT-YGT------KGSGI--GSPSNT-------- B7ZS63_XENLA B7ZS63_XENLA SS---------------PGVLMQRSSSFT-YGT------KGSGI--GSPSNN-------- FOXO3_XENLA FOXO3_XENLA SS---------------PGVLMQRSSSFT-YGT------KGSGI--GSPSNN-------- Q4SV53_TETNG Q4SV53_TETNG -----------------GQPALNGSSGFT-FVS------KPNRL--GSTSSTTSPSSNSS Q90YK2_XIPMA Q90YK2_XIPMA -----------------SQAMQNGSSGFS-FGS------KPNGI--GSPSSTSSPSSNNS Q4REI0_TETNG Q4REI0_TETNG -------TATQQLPPGEEDSGGQATSVFT-FSC------SGSSL--GSP----------- Q5I0F7_DANRE Q5I0F7_DANRE -----------PGHDE-SGANLQGSPVFT-FSC------SGSSL--AIPSGS-------- FOXO6_HUMAN FOXO6_HUMAN ------------------------------------------------------------ FOXO6_MOUSE FOXO6_MOUSE -----------------GPRARAGTPSY--FGS------CKASA---------------- Q5RJI9_MOUSE Q5RJI9_MOUSE -----------------GPRARAGTPSY--FGS------CKASA---------------- Q4T8Y3_TETNG Q4T8Y3_TETNG -------PPQQHHQQHSSVGRHKQQPFYH-YSP---------VV--KSP----------- A5PF57_DANRE A5PF57_DANRE -----------------SQPLPLKRNGYH-YGP-------------APKAETS------- B4F6Q7_DANRE B4F6Q7_DANRE -----------------SQPLPLKRNGYH-YGP-------------APKAETS------- MATCH CONSENSUS ????????????????????????????????????????????????????????????

B3UYC2_BRAFL B3UYC2_BRAFL -------F--KSPFSPVQV-----PQPAHSPNQQQGSLPSVNAPQQDPTQFSLQQLSDVM Q4S8Z6_TETNG Q4S8Z6_TETNG -------YR-KCMYSHMRM-NSLSSAHVQTLHGNKP-VFTA---YENQYICSAGLLKELL A3RK75_DANRE A3RK75_DANRE -------YR-KCLYGQGGV-GGLNPISIPTLSDSKPGGYGP---FVGQYNCAPGLLKELL FOXO1_XENLA FOXO1_XENLA -------YR-KYSYAQTGI-SPISQMPMQTVPENKS-GYR----AVGQYPVPAGLLKELL FOXO1_XENTR FOXO1_XENTR -------YR-KYSYAQTGM-NPVSQMPMQTVPENKS-GYR----AVGQYPVPAGLLKELL Q9W7F9_CHICK Q9W7F9_CHICK -------YR-KFTYAQASM-NSLPQIPMQTLQDSKS-SYG----SMSQFNCPAGLLKELL FOXO1_HUMAN FOXO1_HUMAN -------YQ-KYTYGQSSM-SPLPQMPIQTLQDNKS-SYG----GMSQYNCAPGLLKELL FOXO1_SPETR FOXO1_SPETR -------YQ-KYTYGQSSM-SPLSQMPMQTLQDNKS-SYG----GLNQFNCAQGLLKELL A4L7N3_PIG A4L7N3_PIG -------YQ-KYTYGQSSM-SPLPQMPMQTLQDSKS-SYG----GMAQYNCAAGLLKELL Q8MK69_PIG Q8MK69_PIG -------YQ-KYTYGQSSM-SPLPQMPMQTLQDSKS-SYG----GMAQYNCAAGLLKELL Q9ES26_RAT Q9ES26_RAT -------YA-KYTYGQSSM-SPVPQMPMQTLQDSKS-SYG----GLNQYNCAPGLLKELL Q9WVH5_MOUSE Q9WVH5_MOUSE -------YS-KYTYGQSSM-SPLPQMPMQTLQDSKS-SYG----GLNQYNCAPGLLKELL Q8BPP2_MOUSE Q8BPP2_MOUSE -------YS-KYTYGQSSM-SPLPQMPMQTLQDSKS-SYG----GLNQYNCAPGLLKELL Q9JJW4_MOUSE Q9JJW4_MOUSE -------YS-KYTYGQSSM-SPLPQMPMQTLQDSKS-SYG----GLNQYNCAPGLLKELL FOXO1_MOUSE FOXO1_MOUSE -------YS-KYTYGQSSM-SPLPQMPMQTLQDSKS-SYG----GLNQYNCAPGLLKELL Q4RFQ3_TETNG Q4RFQ3_TETNG -------YH-KCVYGQAGM-NSLSSMPLQTLQENKP-SFGP---ALGPYNCPAGLLKELL A3RK74_DANRE A3RK74_DANRE -------FR-KCLYGQAGM-GSMSPMPMQPLPESKP-SFGPGGGTMGQFNCTAGLLKELL B1AUT2_MOUSE B1AUT2_MOUSE -------YG-ASLFGPID--GSLSAGE--------------------GCFSSSQSLEALL B1AUT3_MOUSE B1AUT3_MOUSE -------YG-ASLFGPID--GSLSAGE--------------------GCFSSSQSLEALL FOXO4_MOUSE FOXO4_MOUSE -------YG-ASLFGPID--GSLSAGE--------------------GCFSSSQSLEALL A6QLP0_BOVIN A6QLP0_BOVIN -------YS-TSLFSPA-------EGPLSAGE---------------GCFSSSQSLEALL B4DTB6_HUMAN B4DTB6_HUMAN -------YS-SSLFSPA-------EGPLSAGE---------------GCFSSSQALEALL A6NID2_HUMAN A6NID2_HUMAN -------YS-SSLFSPA-------EGPLSAGE---------------GCFSSSQALEALL A8MXF0_HUMAN A8MXF0_HUMAN -------YS-SSLFSPA-------EGPLSAGE---------------GCFSSSQALEALL FOXO4_HUMAN FOXO4_HUMAN -------YS-SSLFSPA-------EGPLSAGE---------------GCFSSSQALEALL B7WPJ7_HUMAN B7WPJ7_HUMAN -------YS-SSLFSPA-------EGPLSAGE---------------GCFSSSQALEALL B3DGQ4_DANRE B3DGQ4_DANRE GG-----FS-NPIFGPSP--GSLRQKPMQTIQENKQTSFS-------SISCFETSLQDLL Q5TYS1_DANRE Q5TYS1_DANRE GG-----FS-NPIFGPSP--GSLRQKPMQTIQENKQTSFS-------SISCFETSLQDLL Q9W7F8_DANRE Q9W7F8_DANRE GG-----FS-NPIFGPSP--GSLRQKPMQTIQENKQTSFS-------SISCFETSLQDLL B4E1P9_HUMAN B4E1P9_HUMAN -------FN-STVFGPSSL-NSLRQSPMQTIQENKPATFS------SMSHYGNQTLQDLL Q9WVH4_MOUSE Q9WVH4_MOUSE -------FN-STVFGPSSL-NSLRQSPMQTIQENRPATFS------SVSHYGNQTLQDLL FOXO3_HUMAN FOXO3_HUMAN -------FN-STVFGPSSL-NSLRQSPMQTIQENKPATFS------SMSHYGNQTLQDLL B4DVZ6_HUMAN B4DVZ6_HUMAN -------FN-STVFGPSSL-NSLRQSPMQTIQENKPATFS------SMSHYGNQTLQDLL Q68DV3_HUMAN Q68DV3_HUMAN -------FN-STVFGPSSL-NSLRQSPMQTIQENKPATFS------SMSHYGNQTLQDLL A2A1E7_PIG A2A1E7_PIG -------FS-STVFGPSSL-NSLRQAPMQTIQENKPATFS------SMSQWPNQTLQDLL B5UA80_PIG B5UA80_PIG -------FS-STVFGPSSL-NSLRQAPMQTIQENKPATFS------SMSHYGNQTLQDLL Q1A729_PIG Q1A729_PIG -------FS-STVFGPSSL-NSLRQAPMQTIQENKPATFS------SMSHYGNQTLQDLL A4IIM7_XENTR A4IIM7_XENTR -------FN-NTSSFNFPL-TSLRQSPMQTIQENKQATFS------SINHYSNQSLQDLL B7ZS63_XENLA B7ZS63_XENLA -------FN-NTGSFNFPL-TSLRQSPMQTIQENKQATFS------SMNHYSNQSLQDLL FOXO3_XENLA FOXO3_XENLA -------FN-NTGSFNFPL-TSLRQSPMQTIQENKQATFS------SMNHYSNQSLQDLL Q4SV53_TETNG Q4SV53_TETNG PNCGMNGYT-NSIFGPHKTGSSLCPSPMQTIQENKQTSFS----SISLARFGSQTLQDLL Q90YK2_XIPMA Q90YK2_XIPMA SNGGGNSYS-NSIFSPYTAGSSLRPSPMQTIQENKQTSFS----TTGMSHFGSHTLQDLL Q4REI0_TETNG Q4REI0_TETNG ------------LFSPPSI-TSLRQSPMQTIQENKQTTFSCV-----SHFGDHQSLQDLL Q5I0F7_DANRE Q5I0F7_DANRE -------YGTNSLFSPPSV-TGLRQSPMQTIQENKQATFSC------GSLFSEQSLQDLL FOXO6_HUMAN FOXO6_HUMAN ----------QDAYGPRP------------------------------------------ FOXO6_MOUSE FOXO6_MOUSE -------YGGGGGFGPPAL-GSLRRLPMQTIQENKQASFV-----QAAAPFRPGALPALL Q5RJI9_MOUSE Q5RJI9_MOUSE -------YGGGGGFGPPAL-GSLRRLPMQTIQENKQASFV-----QAAAPFRPGALPALL Q4T8Y3_TETNG Q4T8Y3_TETNG -------YS-AGGYSATGMGIICHHSPMQTIQENKPTSFS----GTMQAYSSTNALQSLL A5PF57_DANRE A5PF57_DANRE -------YC-GTVYGQPSMGMLRHHTPMQTIQENKPTSFQ----RALRAYSENNALESLL B4F6Q7_DANRE B4F6Q7_DANRE -------YC-GTVYGQPSMGMLRHHTPMQTIQENKPTSFQ----RALRAYSENNALESLL MATCH CONSENSUS ??????????????????????????P????????????????????????????L??LL

B3UYC2_BRAFL B3UYC2_BRAFL LTQTDPILTSGDPVMS-SVDP---LISQGN--LMLRQDPMMSGCPDQ------------- Q4S8Z6_TETNG Q4S8Z6_TETNG TSD---ADASRD-MRP-SMDS---QVSEISR----------------------------- A3RK75_DANRE A3RK75_DANRE TAD---ADPRGELMQSGEGQP---VLPSYASQGQMAQGGK-------------------- FOXO1_XENLA FOXO1_XENLA TSD---SPPHND-ILT-PVDP---AVSQANN-RVLGQNSL-------------------- FOXO1_XENTR FOXO1_XENTR TSD---SPPHND-ILT-PVDS---AVSQANS-RVLAQNSL-------------------- Q9W7F9_CHICK Q9W7F9_CHICK TSD---SPPHND-ILA-SVDT---GVSQAGG-RALGQGVL-------------------- FOXO1_HUMAN FOXO1_HUMAN TSD---SPPHND-IMT-PVDP---GVAQPNS-RVLGQNVM-------------------- FOXO1_SPETR FOXO1_SPETR TSD---SPPHND-IMS-SVDP---GVAQPNS-RVLGQNVM-------------------- A4L7N3_PIG A4L7N3_PIG TSD---SPPHND-IMT-PVDP---GVAQPNS-RVLGQNVL-------------------- Q8MK69_PIG Q8MK69_PIG TSD---SPPHND-IMT-PVDP---GVAQPNS-RVLGQNVL-------------------- Q9ES26_RAT Q9ES26_RAT TSD---SPPHND-IMS-PVDP---GVAQPNS-RVLGQNVL-------------------- Q9WVH5_MOUSE Q9WVH5_MOUSE TSD---SPPHND-IMS-PVDP---GVAQPNS-RVLGQNVM-------------------- Q8BPP2_MOUSE Q8BPP2_MOUSE TSD---SPPHND-IMS-PVDP---GVAQPNS-RVLGQNVM-------------------- Q9JJW4_MOUSE Q9JJW4_MOUSE TSD---SPPHND-IMS-PVDP---GVAQPNS-RVLGQNVM-------------------- FOXO1_MOUSE FOXO1_MOUSE TSD---SPPHND-IMS-PVDP---GVAQPNS-RVLGQNVM-------------------- Q4RFQ3_TETNG Q4RFQ3_TETNG TSD---TDQHGE-LMP-SVDT---GVSQSSGSCMLPPYSS-------------------- A3RK74_DANRE A3RK74_DANRE TSD---GEPGD--LMP-SVDT---VVSQSAG----GSGCM-------------------- B1AUT2_MOUSE B1AUT2_MOUSE TSDT--PPPPADVLMT-QVDP---ILSQAPT-LLLLGGM--------------------- B1AUT3_MOUSE B1AUT3_MOUSE TSDT--PPPPADVLMT-QVDP---ILSQAPT-LLLLGGM--------------------- FOXO4_MOUSE FOXO4_MOUSE TSDT--PPPPADVLMT-QVDP---ILSQAPT-LLLLGGM--------------------- A6QLP0_BOVIN A6QLP0_BOVIN TSDT--PPPPADVLMT-QVDP---ILSQAPT-LLLLGGI--------------------- B4DTB6_HUMAN B4DTB6_HUMAN TSD---TPPPP------------------------------------------------- A6NID2_HUMAN A6NID2_HUMAN TSDT--PPPPADVLMT-QVDP---ILSQAPT-LLLLGGL--------------------- A8MXF0_HUMAN A8MXF0_HUMAN TSDT--PPPPADVLMT-QVDP---ILSQAPT-LLLLGGL--------------------- FOXO4_HUMAN FOXO4_HUMAN TSDT--PPPPADVLMT-QVDP---ILSQAPT-LLLLGGL--------------------- B7WPJ7_HUMAN B7WPJ7_HUMAN TSDT--PPPPADVLMT-QVDP---ILSQAPT-LLLLGGL--------------------- B3DGQ4_DANRE B3DGQ4_DANRE NSDSLVSHSHSDVMMT-QSDP---LISQASA-AVTSQNYR-------------------- Q5TYS1_DANRE Q5TYS1_DANRE NSDSLVSHSHSDVMMT-QSDP---LISQASA-AVTSQNYR-------------------- Q9W7F8_DANRE Q9W7F8_DANRE NSDSLVSHSHSDVMMT-QSDP---LISQASA-AVTSQNYR-------------------- B4E1P9_HUMAN B4E1P9_HUMAN TSD---SLSHSDVMMT-QSDP---LMSQAST-AVSAQNSR-------------------- Q9WVH4_MOUSE Q9WVH4_MOUSE ASD---SLSHSDVMMT-QSDP---LMSQAST-AVSAQNAR-------------------- FOXO3_HUMAN FOXO3_HUMAN TSD---SLSHSDVMMT-QSDP---LMSQAST-AVSAQNSR-------------------- B4DVZ6_HUMAN B4DVZ6_HUMAN TSD---SLSHSDVMMT-QSDP---LMSQAST-AVSAQNSR-------------------- Q68DV3_HUMAN Q68DV3_HUMAN TSD---SLSHSDVMMT-QSDP---LMSQAST-AVSAQNSR-------------------- A2A1E7_PIG A2A1E7_PIG TSD---SLSHSDVMMT-QSDP---LMSQAST-AVSAQNSR-------------------- B5UA80_PIG B5UA80_PIG TSD---SLSHSDVMMT-QSDP---LMSQAST-AVSAQNSR-------------------- Q1A729_PIG Q1A729_PIG TSD---SLSHSDVMMT-QSDP---LMSQAST-AVSAQNSR-------------------- A4IIM7_XENTR A4IIM7_XENTR NTD---TLSHSDVLMT-QSDP---LMSQAST-AVTAQNTR-------------------- B7ZS63_XENLA B7ZS63_XENLA NTD---TLSHSDVLMT-QSDP---LMSQAST-AVTAQNSR-------------------- FOXO3_XENLA FOXO3_XENLA NTD---TLSHSDVLMT-QSDP---LMSQAST-AVTAQNSR-------------------- Q4SV53_TETNG Q4SV53_TETNG NAD---SHNHSDVMMT-QGA----MVKWCKI----------------------------- Q90YK2_XIPMA Q90YK2_XIPMA NSD---SHNHSDVMMT-QSDP---LMSQASAVAIISQNSR-------------------- Q4REI0_TETNG Q4REI0_TETNG SLD---SHGHSNVMLT-QSDP---LMSQAST-AVALQNSR-------------------- Q5I0F7_DANRE Q5I0F7_DANRE SSE---SSSRSDVLLT-QSDP---LMSQASA-SVSSQNAR-------------------- FOXO6_HUMAN FOXO6_HUMAN ------APRPGPVLGA-PGEL---ALAGAAA-AYPGKGAA-------------------- FOXO6_MOUSE FOXO6_MOUSE PPPP--PAPRPGPLLGAPGEL---ALAGAAA-AYPGKGAA-------------------- Q5RJI9_MOUSE Q5RJI9_MOUSE PPPP--PAPRPGPLLGAPGEL---ALAGAAA-AYPGKGAA-------------------- Q4T8Y3_TETNG Q4T8Y3_TETNG IGGPAGQQYCSKGTMPVQKRESHSLMGHAGK-GVGSNHHS-------------------- A5PF57_DANRE A5PF57_DANRE AGGP--QYCGKDMVVG-QGGTSHSLMSQSNT-AV-------------------------- B4F6Q7_DANRE B4F6Q7_DANRE AGGP--QYCGKDMVVG-QGGTSHSLMSQSNT-AVHSHGHNQSHNHSQNHNHNPEHGHNRN MATCH CONSENSUS ??D????????D???????D???????Q????????????????????????????????

B3UYC2_BRAFL B3UYC2_BRAFL ---------------------GSQLSSLLQGTGMSYAFRQQQQ----------------Q Q4S8Z6_TETNG Q4S8Z6_TETNG ----------------------------GGRPMPVYSSQSHPGGHNGVKMMNPSQTHLVP A3RK75_DANRE A3RK75_DANRE --------------------------------MITH------------------------ FOXO1_XENLA FOXO1_XENLA --------------------------IGSNSIMPAYGSQPAPN----------------- FOXO1_XENTR FOXO1_XENTR --------------------------MAPSSVMPTYGSQPTHN----------------- Q9W7F9_CHICK Q9W7F9_CHICK --------------------------MVTNSVMPTYGNQPPHN----------------- FOXO1_HUMAN FOXO1_HUMAN --------------------------MGPNSVMSTYGSQASHN----------------- FOXO1_SPETR FOXO1_SPETR --------------------------LGPNSVMPAYGNQASHN----------------- A4L7N3_PIG A4L7N3_PIG --------------------------MGPSSVMPAYGGQASHN----------------- Q8MK69_PIG Q8MK69_PIG --------------------------MGPSSVMPAYGGQASHN----------------- Q9ES26_RAT Q9ES26_RAT --------------------------MGPNSVMPAY------------------------ Q9WVH5_MOUSE Q9WVH5_MOUSE --------------------------MGPNSVMPAYGSQASHN----------------- Q8BPP2_MOUSE Q8BPP2_MOUSE --------------------------MGPNSVMPAYGSQASHN----------------- Q9JJW4_MOUSE Q9JJW4_MOUSE --------------------------MGPNSVMPAYGSQASHN----------------- FOXO1_MOUSE FOXO1_MOUSE --------------------------MGPNSVMPAYGSQASHN----------------- Q4RFQ3_TETNG Q4RFQ3_TETNG ----------------------------SQHASKLRGNGRPHG----------------- A3RK74_DANRE A3RK74_DANRE ---------------------LPPYSSGRNELM---GGGPTHS----------------- B1AUT2_MOUSE B1AUT2_MOUSE ------------------------------------------------------------ B1AUT3_MOUSE B1AUT3_MOUSE ------------------------------------------------------------ FOXO4_MOUSE FOXO4_MOUSE ------------------------------------------------------------ A6QLP0_BOVIN A6QLP0_BOVIN ------------------------------------------------------------ B4DTB6_HUMAN B4DTB6_HUMAN ------------------------------------------------------------ A6NID2_HUMAN A6NID2_HUMAN ------------------------------------------------------------ A8MXF0_HUMAN A8MXF0_HUMAN ------------------------------------------------------------ FOXO4_HUMAN FOXO4_HUMAN ------------------------------------------------------------ B7WPJ7_HUMAN B7WPJ7_HUMAN ------------------------------------------------------------ B3DGQ4_DANRE B3DGQ4_DANRE ---------------------LRNNPMLRNDPMMSSFSSVLNG----------------R Q5TYS1_DANRE Q5TYS1_DANRE ---------------------LRNNPMLRNDPMMSSFSSVLNG----------------R Q9W7F8_DANRE Q9W7F8_DANRE ---------------------LRNNPMLRNDPMMSSFSSVLNG----------------R B4E1P9_HUMAN B4E1P9_HUMAN -----------------------RNVMLRNDPMMSFAAQPNQG----------------- Q9WVH4_MOUSE Q9WVH4_MOUSE -----------------------RNVMLRNDPMMSFAAQPTQG----------------- FOXO3_HUMAN FOXO3_HUMAN -----------------------RNVMLRNDPMMSFAAQPNQG----------------- B4DVZ6_HUMAN B4DVZ6_HUMAN -----------------------RNVMLRNDPMMSFAAQPNQG----------------- Q68DV3_HUMAN Q68DV3_HUMAN -----------------------RNVMLRNDPMMSFAAQPNQG----------------- A2A1E7_PIG A2A1E7_PIG -----------------------RNVMLRNDPMMSFAAQPNQG----------------- B5UA80_PIG B5UA80_PIG -----------------------RNVMLRSDPMMSFAAQPNQG----------------- Q1A729_PIG Q1A729_PIG -----------------------RNVMLRSDPMMSFAAQPNQG----------------- A4IIM7_XENTR A4IIM7_XENTR -----------------------RNIILRNDPMMSFAAPSNQG----------------G B7ZS63_XENLA B7ZS63_XENLA -----------------------RNIILRNDPMMSFAAQPNQG----------------G FOXO3_XENLA FOXO3_XENLA -----------------------RNIILRNDPMMSFAAQPNQG----------------G Q4SV53_TETNG Q4SV53_TETNG ------------------------------------------------------------ Q90YK2_XIPMA Q90YK2_XIPMA -----------------------RNVMVRNDPVMTFGTTGGLQ----------------- Q4REI0_TETNG Q4REI0_TETNG ----------------------RNAMLLHKDPPSVNHTGAGQA----------------- Q5I0F7_DANRE Q5I0F7_DANRE ------------------------RILLRNDPMMSNQAGP-------------------- FOXO6_HUMAN FOXO6_HUMAN ----------------------------------PYAPPA-------------------- FOXO6_MOUSE FOXO6_MOUSE ----------------------------------PYAPPA-------------------- Q5RJI9_MOUSE Q5RJI9_MOUSE ----------------------------------PYAPPA-------------------- Q4T8Y3_TETNG Q4T8Y3_TETNG -----------------------HRPCHSNGCSHNRPSSHSHN-------------RTHS A5PF57_DANRE A5PF57_DANRE ------------------------------------------------------------ B4F6Q7_DANRE B4F6Q7_DANRE SSQSLHNGHGVTHEQNPSHHHNPNQAHNKHHPSLDYNHHKQHRGHDYVQSHDHKLNASPN MATCH CONSENSUS ????????????????????????????????????????????????????????????

B3UYC2_BRAFL B3UYC2_BRAFL QLQQQQQQQQQQQP---------------QQQPQQQNY---------------------- Q4S8Z6_TETNG Q4S8Z6_TETNG HVNPHV--INSQVP---------------LTTHDLKAC---------------------- A3RK75_DANRE A3RK75_DANRE ----PHLHAHPRSLHQLP-----------SPAMGLNGC---------------------- FOXO1_XENLA FOXO1_XENLA K-MSSHPHLHQ-------P----------NHPTSINGR---------------------- FOXO1_XENTR FOXO1_XENTR K-MSSHPHSHQ--PP---P----------NHP-SVNGR---------------------- Q9W7F9_CHICK Q9W7F9_CHICK KMMNPNARPHQ--GH---N----------QPTPAVNGR---------------------- FOXO1_HUMAN FOXO1_HUMAN KMMNPSSHTHP--GH---A----------QQTSAVNGR---------------------- FOXO1_SPETR FOXO1_SPETR KMMNPSSHTHP--GH---A----------QQTSVVNGR---------------------- A4L7N3_PIG A4L7N3_PIG KMMNPSSHSHP--GH---A----------QSTSAVNGR---------------------- Q8MK69_PIG Q8MK69_PIG KMMNPSSHSHP--GH---G----------QSTSAVNGR---------------------- Q9ES26_RAT Q9ES26_RAT ------------------------------------------------------------ Q9WVH5_MOUSE Q9WVH5_MOUSE KMMNPSSHTHP--GH---A----------QQTASVNGR---------------------- Q8BPP2_MOUSE Q8BPP2_MOUSE KMMNPSSHTHP--GH---A----------QQTASVNGR---------------------- Q9JJW4_MOUSE Q9JJW4_MOUSE KMMNPSSHTHP--GH---A----------QQTASVNGR---------------------- FOXO1_MOUSE FOXO1_MOUSE KMMNPSSHTHP--GH---A----------QQTASVNGR---------------------- Q4RFQ3_TETNG Q4RFQ3_TETNG -----LPHTHPHPVHQAT-----------VTPSAMNGR---------------------- A3RK74_DANRE A3RK74_DANRE -----HTLSHPHNMHGQAP----------PTSVALNG----------------------- B1AUT2_MOUSE B1AUT2_MOUSE -----------------------------PSSSKLGTG---------------------- B1AUT3_MOUSE B1AUT3_MOUSE -----------------------------PSSSKLGTG---------------------- FOXO4_MOUSE FOXO4_MOUSE -----------------------------PSSSKLGTG---------------------- A6QLP0_BOVIN A6QLP0_BOVIN -----------------------------PSSSKLGTG---------------------- B4DTB6_HUMAN B4DTB6_HUMAN ------------------------------------------------------------ A6NID2_HUMAN A6NID2_HUMAN -----------------------------PSSSKLATG---------------------- A8MXF0_HUMAN A8MXF0_HUMAN -----------------------------PSSSKLATG---------------------- FOXO4_HUMAN FOXO4_HUMAN -----------------------------PSSSKLATG---------------------- B7WPJ7_HUMAN B7WPJ7_HUMAN -----------------------------PSSSKLATG---------------------- B3DGQ4_DANRE B3DGQ4_DANRE SGHLQNKQHH-------------------QGSNGQGSL---------------------- Q5TYS1_DANRE Q5TYS1_DANRE SGHLQNKQHH-------------------QGSNGQGSL---------------------- Q9W7F8_DANRE Q9W7F8_DANRE SGHLQNKQHH-------------------QGSNGQGSL---------------------- B4E1P9_HUMAN B4E1P9_HUMAN SLVNQNLLHHQH-----------------QTQGALGGS---------------------- Q9WVH4_MOUSE Q9WVH4_MOUSE SLVNQNLLHHQH-----------------QTQGALGGS---------------------- FOXO3_HUMAN FOXO3_HUMAN SLVNQNLLHHQH-----------------QTQGALGGS---------------------- B4DVZ6_HUMAN B4DVZ6_HUMAN SLVNQNLLHHQH-----------------QTQGALGGS---------------------- Q68DV3_HUMAN Q68DV3_HUMAN SLVNQNLLHHQH-----------------QTQGALGGS---------------------- A2A1E7_PIG A2A1E7_PIG SLVNQNLLHHQH-----------------QTQGALGGS---------------------- B5UA80_PIG B5UA80_PIG SLVNQNLLHHQH-----------------QTQGALGGS---------------------- Q1A729_PIG Q1A729_PIG SLVNQNLLHHQH-----------------QTQGALGGS---------------------- A4IIM7_XENTR A4IIM7_XENTR NLVNQNSLHQQQ-----------------SLNSFQGGS---------------------- B7ZS63_XENLA B7ZS63_XENLA NLVNQNSLHQQQ-----------------SLNSFQGGS---------------------- FOXO3_XENLA FOXO3_XENLA NLVNQNSLHQQQ-----------------SLNSFQGGS---------------------- Q4SV53_TETNG Q4SV53_TETNG -----------------------------DPSIFLNG----------------------- Q90YK2_XIPMA Q90YK2_XIPMA SSHRETLQTNNHNQ---------------STVRSLNGD---------------------- Q4REI0_TETNG Q4REI0_TETNG -----------------------------QSSSVPGWQ---------------------- Q5I0F7_DANRE Q5I0F7_DANRE -----------------------------AGQAGLKKA---------------------- FOXO6_HUMAN FOXO6_HUMAN -----------------------------PSRSALAHP---------------------- FOXO6_MOUSE FOXO6_MOUSE -----------------------------PSRSALAHP---------------------- Q5RJI9_MOUSE Q5RJI9_MOUSE -----------------------------PSRSALAHP---------------------- Q4T8Y3_TETNG Q4T8Y3_TETNG HAHNHNVNNHNSPHSLTKSGHNLSHNHTPPHPVSLTTNGNGNQLHTYNQKKPYLYSPPLH A5PF57_DANRE A5PF57_DANRE ------------------------------------------------------------ B4F6Q7_DANRE B4F6Q7_DANRE HMHNHLQHNNSRQPDLSPRVSNDMLQPYNHKSPSLYGP---------------------- MATCH CONSENSUS ????????????????????????????????????????????????????????????

B3UYC2_BRAFL B3UYC2_BRAFL NLGCALNQMLGGNMGIMT-----GQLAPTQQQQQTPLP-QISTFGMMHQQSPAS-LHQQA Q4S8Z6_TETNG Q4S8Z6_TETNG NTIPLTSLTSFPGAP--------AQMTSLKACVQLS---HGLPANSASSSYSYR-ELNSV A3RK75_DANRE A3RK75_DANRE AMLPHGHP---------------VRLSSMKPQPHLP---HHTHLGRGGGEAGMP-SYTNG FOXO1_XENLA FOXO1_XENLA -------PIAHNPGI--------NRLSTVKTSVQVPMPHQPIQMTSMG---SY--SMNSC FOXO1_XENTR FOXO1_XENTR -------TMTHNSGI--------NRLSTVKTSVQVPMP-QPIQMTSMG---SY--PVNSC Q9W7F9_CHICK Q9W7F9_CHICK ALSHTVNPMSHTSCL--------NRLSTVKTSLQVPMS-HQMQMNAMN---PYA-PVNSC FOXO1_HUMAN FOXO1_HUMAN PLPHTVSTMPHTSGM--------NRLTQVKTPVQVPLP-HPMQMSALG---GYS-SVSSC FOXO1_SPETR FOXO1_SPETR ALPHTVNTMPHTSGM--------NRLTPVKTPLQVPLL-HHMQMSALG---GYS-SVSSC A4L7N3_PIG A4L7N3_PIG ALPHAVNTMPHASGM--------NRLTQEKTALQVPLP-HPMQMNALG---GYS-PASTC Q8MK69_PIG Q8MK69_PIG ALPHAVNTMPHASGM--------NRLAQEKTALQVPLP-HPMQMNALG---GYS-PASTC Q9ES26_RAT Q9ES26_RAT ------------------------------------------------------------ Q9WVH5_MOUSE Q9WVH5_MOUSE TPPHVVNTMPHTSAM--------NRLTPVKTPLQVPLS-HPMQMSALG---RYS-SVSSC Q8BPP2_MOUSE Q8BPP2_MOUSE TLPHVVNTMPHTSAM--------NRLTPVKTPLQVPLS-HPMQMSALG---SYS-SVSSC Q9JJW4_MOUSE Q9JJW4_MOUSE TLPHVVNTMPHTSAM--------NRLTPVKTPLQVPLS-HPMQMSALG---SYS-SVSSC FOXO1_MOUSE FOXO1_MOUSE TLPHVVNTMPHTSAM--------NRLTPVKTPLQVPLS-HPMQMSALG---SYS-SVSSC Q4RFQ3_TETNG Q4RFQ3_TETNG LLMPLNHSGAT------------TCLPTVKSPMQMS---YGLSGHLSGGGIPGSFCPLNT A3RK74_DANRE A3RK74_DANRE RSLHPLTAIGHSSVG--------GRLGSGKSPMQMQ---YGGSGHLGGGLPPYC-SM-SS B1AUT2_MOUSE B1AUT2_MOUSE VSLCPTPLEGPGP----------SNLVPNLSVMAPP---PVMAGAPIPKVLGTP-VLASP B1AUT3_MOUSE B1AUT3_MOUSE VSLCPTPLEGPGP----------SNLVPNLSVMAPP---PVMAGAPIPKVLGTP-VLASP FOXO4_MOUSE FOXO4_MOUSE VSLCPTPLEGPGP----------SNLVPNLSVMAPP---PVMAGAPIPKVLGTP-VLASP A6QLP0_BOVIN A6QLP0_BOVIN GGLCPKPLEAAGPSG--------LVPTLPMIAPAPP---PVMGGAPVPKPLGAP-VLTPP B4DTB6_HUMAN B4DTB6_HUMAN ---------------------------------------AVGSHHFLCQRLAYP------ A6NID2_HUMAN A6NID2_HUMAN VGLCPKPLEAPGP----------SSLVPTLSMIAPP---PVMASAPIPKALGTP-VLTPP A8MXF0_HUMAN A8MXF0_HUMAN VGLCPKPLEAPGP----------SSLVPTLSMIAPP---PVMASAPIPKALGTP-VLTPP FOXO4_HUMAN FOXO4_HUMAN VGLCPKPLEAPGP----------SSLVPTLSMIAPP---PVMASAPIPKALGTP-VLTPP B7WPJ7_HUMAN B7WPJ7_HUMAN VGLCPKPLEAPGP----------SSLVPTLSMIAPP---PVMASAPIPKALGTP-VLTPP B3DGQ4_DANRE B3DGQ4_DANRE RSLSNNRAQSLVNDA--------NNLVSAKQLLQPQ---PTMLMTETP---LYS-GMNGS Q5TYS1_DANRE Q5TYS1_DANRE RSLSNNRAQSLVNDA--------NNLVSAKQLLQPQ---PTMLMTETP---LYT-GMNGS Q9W7F8_DANRE Q9W7F8_DANRE RSLSNNRAQSLVNDA--------NNLVSAKQLLQPQ---PTMLMTETP---LYS-GMNGS B4E1P9_HUMAN B4E1P9_HUMAN RALSNSVSNMGLSES--------SSLGSAKHQQQSP---VSQSMQTLSDSLSGS-SLYST Q9WVH4_MOUSE Q9WVH4_MOUSE RALSNSVSNMGLSDS--------SSLGSAKHQQQSP---ASQSMQTLSDSLSGS-SLYSA FOXO3_HUMAN FOXO3_HUMAN RALSNSVSNMGLSES--------SSLGSAKHQQQSP---VSQSMQTLSDSLSGS-SLYST B4DVZ6_HUMAN B4DVZ6_HUMAN RALSNSVSNMGLSES--------SSLGSAKHQQQSP---VSQSMQTLSDSLSGS-SLYST Q68DV3_HUMAN Q68DV3_HUMAN RALSNSVSNMGLSES--------SSLGSAKHQQQSP---VSQSMQTLSDSLSGS-SLYST A2A1E7_PIG A2A1E7_PIG RALSNSVSSMGLSDS--------SSLGSAKHQQQSP---VSQSMQTLSDSLSGS-SLYST B5UA80_PIG B5UA80_PIG RALSNSASSMGLSDS--------SSLGSAKHQQQSP---VSQSMQTLSDSLSGS-SLYST Q1A729_PIG Q1A729_PIG RALSNSVSSMGLSDS--------SSLGSAKHQQQSP---VSQSMQTLSDSLSGS-SLYST A4IIM7_XENTR A4IIM7_XENTR RALSNNLSNTGLNDS--------SNLDSTKHQQQSS---VSHSMQTISDTLSG--SLYSS B7ZS63_XENLA B7ZS63_XENLA RALSNNLSNTGLNDS--------SILESTKHQQQSS---VSHSMQTISDTLSG--SLYSS FOXO3_XENLA FOXO3_XENLA RALSNNLSNTGLNDS--------SILESTKHQQQSS---VSHSMQTISDTLSG--SLYSS Q4SV53_TETNG Q4SV53_TETNG ---------------------------------------------------------TSS Q90YK2_XIPMA Q90YK2_XIPMA LNLANEA----------------NTLANVKQQLLLS---PIGGNGTSSMQIDTS-IFLNG Q4REI0_TETNG Q4REI0_TETNG AGLSTSEDNGGRNN---------AKQPHLKSPSKNA-------------------SMQLG Q5I0F7_DANRE Q5I0F7_DANRE SPSGWRMNCVPSSES--------DYQSLMKQLQQSPFRSTSMQLNSSDSLLAG---LNGS FOXO6_HUMAN FOXO6_HUMAN ISLMTLPGEAGAAGL--------APPGHAAAFGGPP---GGLLLDALPG--PYAAAAAGP FOXO6_MOUSE FOXO6_MOUSE ISLMTLPGEAGAAGL--------APPAHAAAFGGPP---GGLLLDALPG--PYAAAAAGP Q5RJI9_MOUSE Q5RJI9_MOUSE ISLMTLPGEAGAAGL--------APPAHAAAFGGPP---GGLLLDALPG--PYAAAAAGP Q4T8Y3_TETNG Q4T8Y3_TETNG AHLPASTTLPPNPAGMPGMPQDSCYVATAPHPRHNYHPGPQLQGMTNG---PYNHGQSVG A5PF57_DANRE A5PF57_DANRE ------------------------------------------------------------ B4F6Q7_DANRE B4F6Q7_DANRE RAHLPSTALPPNPASVLDVPQDPCRLASAPHPRHQSYPGSHLHQGMTEPWQGY--YHHTS MATCH CONSENSUS ????????????????????????????????????????????????????????????

B3UYC2_BRAFL B3UYC2_BRAFL MANSQANQL----LSMHQEKFPSDLELDMFS-GGLE--CDMDSIINTELMED-GGLEFNF Q4S8Z6_TETNG Q4S8Z6_TETNG NPHSH-----------HQERLPSDLD-SVSI-EGFE--CDMDTILYETFMDG-GSLDFNF A3RK75_DANRE A3RK75_DANRE NGFHR-HGAIAHHHHSHPERLPSDLD-DMLI-DQLDVECDVERVLHDTLMDG-DALDFNF FOXO1_XENLA FOXO1_XENLA NGYGR-VGI----VSIHQEILPSDLD-DMLI-ESLD--CDVESIIRNDLMED-GEADFNF FOXO1_XENTR FOXO1_XENTR NGYGR-VGI----VSIHQEILPSDLD-DMFI-ESLD--CDMESIIRNDLMED-GEADFNF Q9W7F9_CHICK Q9W7F9_CHICK NGYGR-VGI----VSLHQEKLPSDLD-DMLI-ERLD--CDMESIIRNDLMDG-ETLDFNF FOXO1_HUMAN FOXO1_HUMAN NGYGR-MGL------LHQEKLPSDLD-GMFI-ERLD--CDMESIIRNDLMDG-DTLDFNF FOXO1_SPETR FOXO1_SPETR SGYGR-MGV------LHQEKLPSDLD-GMFI-ERLD--CDMESIIRNDLMDG-DALDFNF A4L7N3_PIG A4L7N3_PIG NGYGR-MGL------LHQEKLPSDLD-GMFI-ERLD--CDMESIIRNDLMDG-DTLDFNF Q8MK69_PIG Q8MK69_PIG NGYGR-MGL------LHQEKLPSDLD-GMFI-ERLD--CDMESIIRNDLMDG-DTLDFNF Q9ES26_RAT Q9ES26_RAT ------------------------------------------------------------ Q9WVH5_MOUSE Q9WVH5_MOUSE NGYGR-MGV------LHQEKLPSDLD-GMFI-ERLD--CDMESIIRNDLMDG-DTLDFNF Q8BPP2_MOUSE Q8BPP2_MOUSE NGYGR-MGV------LHQEELPSDLD-GMFI-ERLD--CDMESIIRNDLMDG-DTLDFNF Q9JJW4_MOUSE Q9JJW4_MOUSE NGYGR-MGV------LHQEKLPSDLD-GMFI-ERLD--CDMESIIRNDLMDG-DTLDFNF FOXO1_MOUSE FOXO1_MOUSE NGYGR-MGV------LHQEKLPSDLD-GMFI-ERLD--CDMESIIRNDPMDG-DTLDFNF Q4RFQ3_TETNG Q4RFQ3_TETNG NGYGRQGLA----QPSHLEKLPSDLD-DMSI-EKFE--FDMETVLHDTLMDG-DSLDFNF A3RK74_DANRE A3RK74_DANRE NGYGRGPGMMAHQQLQHLEKLPSDLD-GMPI-ERFE--CDVESILHDTLMDG-ESLDFNF B1AUT2_MOUSE B1AUT2_MOUSE TEDSSH------------DRMPQDLDLDMYM-ENLE--CDMDNII-SDLMDG-EGLDFNF B1AUT3_MOUSE B1AUT3_MOUSE TEDSSH------------DRMPQDLDLDMYM-ENLE--CDMDNII-SDLMDG-EGLDFNF FOXO4_MOUSE FOXO4_MOUSE TEDSSH------------DRMPQDLDLDMYM-ENLE--CDMDNII-SDLMDG-EGLDFNF A6QLP0_BOVIN A6QLP0_BOVIN TEAPSQ------------DRMPQDLDLDIYM-ENLE--CDMDNII-NDLMDGDEGLDFNF B4DTB6_HUMAN B4DTB6_HUMAN ---------------------------DCIM-------C--------------------- A6NID2_HUMAN A6NID2_HUMAN TEAASQ------------DRMPQDLDLDMYM-ENLE--CDMDNII-SDLMDEGEGLDFNF A8MXF0_HUMAN A8MXF0_HUMAN TEAASQ------------DRMPQDLDLDMYM-ENLE--CDMDNII-SDLMDEGEGLDFNF FOXO4_HUMAN FOXO4_HUMAN TEAASQ------------DRMPQDLDLDMYM-ENLE--CDMDNII-SDLMDEGEGLDFNF B7WPJ7_HUMAN B7WPJ7_HUMAN TEAASQ------------DRMPQDLDLDMYM-ENLE--CDMDNII-SDLMDEGEGLDFNF B3DGQ4_DANRE B3DGQ4_DANRE NGLGICHPS-------GTDRFPSDLDLDIFN-GSLD--CDVDSIIRSELMDS-DGLDFNF Q5TYS1_DANRE Q5TYS1_DANRE NGLGICHPS-------GTDRFPSDLDLDIFN-GSLD--CDVDSIIRSELMDS-DGLDFNF Q9W7F8_DANRE Q9W7F8_DANRE NGLGICHPS-------GTDRFPSDLDLDIFN-GSLD--CDVDSIIRSELMDS-DGLDFNF B4E1P9_HUMAN B4E1P9_HUMAN SANLPVMGH---------EKFPSDLDLDMLM-GAWNVTWSPLSVVNSWMLMG-----WIL Q9WVH4_MOUSE Q9WVH4_MOUSE SANLPVMGH---------DKFPSDLDLDMFN-GSLE--CDMESIIRSELMDA-DGLDFNF FOXO3_HUMAN FOXO3_HUMAN SANLPVMGH---------EKFPSDLDLDMFN-GSLE--CDMESIIRSELMDA-DGLDFNF B4DVZ6_HUMAN B4DVZ6_HUMAN SANLPVMGH---------EKFPSDLDLDMFN-GSLE--CDMESIIRSELMDA-DGLDFNF Q68DV3_HUMAN Q68DV3_HUMAN SANLPVMGH---------EKFPSDLDLDMFN-GSLE--CDMESIIRSELMDA-DGLDFNF A2A1E7_PIG A2A1E7_PIG SANLPVMGH---------EKFPSDLDLDMFN-GSLN--Y--------------------- B5UA80_PIG B5UA80_PIG SANLPVMGH---------EKFPSDLDLDMFN-GSLE--CDMESIIRSELMDA-DGLDFNF Q1A729_PIG Q1A729_PIG SANLPVMGH---------EKFPSDLDLDMFN-GSLE--CDMESIIRSELMDA-DGLDFNF A4IIM7_XENTR A4IIM7_XENTR AVNLPTLGH---------EKFPTDLDLDIFN-GSLE--CDMETIIRNDLMDA-DGLDFNF B7ZS63_XENLA B7ZS63_XENLA GVTLPTLGH---------EKFPTDLDLDIFN-GSLE--CDMETIIRNDLMDA-DGLDFNF FOXO3_XENLA FOXO3_XENLA GVTLPTLGH---------EKFPTDLDLDIFN-GSLE--CDMETIIRNDLMDA-DGLDFNF Q4SV53_TETNG Q4SV53_TETNG GGICQ-------------DRFPTDLDLDIFN-SSLE--CDMDSIIRNELMDT-DGLDFNF Q90YK2_XIPMA Q90YK2_XIPMA TASSSGGCQ---------DRFPTDLDLDMFNSGSLD--CDMESIIRNDLMDA-DGLDFNF Q4REI0_TETNG Q4REI0_TETNG SGFPSQ------------DRFPADLDLDVFN-SSLE--CDMDAIIRNELMDA-DCLDLSF Q5I0F7_DANRE Q5I0F7_DANRE VTSAQSVSQ---------DRFSSDLDLEAFS-GSFD--CDMDIITRNDLMDA-EGLELSF FOXO6_HUMAN FOXO6_HUMAN LGAAP-------------DRFPADLDLDMFS-GSLE--CDVESIILNDFMDS-DEMDFNF FOXO6_MOUSE FOXO6_MOUSE LGAGP-------------DRFPADLDLDMFS-GSLE--CDVESIILNDFMDS-DEMDFNF Q5RJI9_MOUSE Q5RJI9_MOUSE LGAGP-------------DRFPADLDLDMFS-GSLE--CDVESIILNDFMDS-DEMDFNS Q4T8Y3_TETNG Q4T8Y3_TETNG NGTISSNYH-DYHQSHFPERLPADLDIDMFN-GSLD--CDVESILLHDIMNSGEELDFNF A5PF57_DANRE A5PF57_DANRE ------------------------------------------------------------ B4F6Q7_DANRE B4F6Q7_DANRE QNANYHGNHQASHHHDPQNRLQSELEMDVHQ-SSLD--CDVESILLNDFMDSTEGMDFNF MATCH CONSENSUS ?????????????????????P?DLD????????L???CD???I?????MD?????DFNF

B3UYC2_BRAFL B3UYC2_BRAFL QQ--------------------------------------------DPNNQMGSCAPTSA Q4S8Z6_TETNG Q4S8Z6_TETNG ----------------------------------------------DPSSATHGF-PQR- A3RK75_DANRE A3RK75_DANRE ----------------------------------------------DPMSSQQSFTHSV- FOXO1_XENLA FOXO1_XENLA ----------------------------------------------DSILPNQSF-PHS- FOXO1_XENTR FOXO1_XENTR ----------------------------------------------DSILPNQSF-PHS- Q9W7F9_CHICK Q9W7F9_CHICK ----------------------------------------------DSVLPNQSF-QHS- FOXO1_HUMAN FOXO1_HUMAN ----------------------------------------------DNVLPNQSF-PHS- FOXO1_SPETR FOXO1_SPETR ----------------------------------------------DNVLPNQSF-PHG- A4L7N3_PIG A4L7N3_PIG ----------------------------------------------DNVLPNQSF-PHS- Q8MK69_PIG Q8MK69_PIG ----------------------------------------------DNVLPNQSF-PHS- Q9ES26_RAT Q9ES26_RAT ------------------------------------------------------------ Q9WVH5_MOUSE Q9WVH5_MOUSE ----------------------------------------------DNVLPNQSF-PHS- Q8BPP2_MOUSE Q8BPP2_MOUSE ----------------------------------------------DNVLPNQSF-PHS- Q9JJW4_MOUSE Q9JJW4_MOUSE ----------------------------------------------DNVLPNQSF-PHS- FOXO1_MOUSE FOXO1_MOUSE ----------------------------------------------DNVLPNQSF-PHS- Q4RFQ3_TETNG Q4RFQ3_TETNG ----------------------------------------------EPMVTQQGF-PHG- A3RK74_DANRE A3RK74_DANRE ----------------------------------------------DPMNSQQGFVPHS- B1AUT2_MOUSE B1AUT2_MOUSE ----------------------------------------------EP------------ B1AUT3_MOUSE B1AUT3_MOUSE ----------------------------------------------EPDP---------- FOXO4_MOUSE FOXO4_MOUSE ----------------------------------------------EPDP---------- A6QLP0_BOVIN A6QLP0_BOVIN ----------------------------------------------EPDP---------- B4DTB6_HUMAN B4DTB6_HUMAN ------------------------------------------------------------ A6NID2_HUMAN A6NID2_HUMAN ----------------------------------------------EPAP---------- A8MXF0_HUMAN A8MXF0_HUMAN ----------------------------------------------EPAP---------- FOXO4_HUMAN FOXO4_HUMAN ----------------------------------------------EPDP---------- B7WPJ7_HUMAN B7WPJ7_HUMAN ----------------------------------------------EPDP---------- B3DGQ4_DANRE B3DGQ4_DANRE ----------------------------------------------DALMQNAVSLNPV- Q5TYS1_DANRE Q5TYS1_DANRE ----------------------------------------------DALMQNAVSLNPV- Q9W7F8_DANRE Q9W7F8_DANRE ----------------------------------------------DALMQNAVSLNPV- B4E1P9_HUMAN B4E1P9_HUMAN ----------------------------------------------TLIPSSPHRMLLV- Q9WVH4_MOUSE Q9WVH4_MOUSE ----------------------------------------------DSLISTQNVVGLN- FOXO3_HUMAN FOXO3_HUMAN ----------------------------------------------DSLISTQNVVGLN- B4DVZ6_HUMAN B4DVZ6_HUMAN ----------------------------------------------DSLISTQNVVGLN- Q68DV3_HUMAN Q68DV3_HUMAN ----------------------------------------------DSLISTQNVVGLN- A2A1E7_PIG A2A1E7_PIG ------------------------------------------------------------ B5UA80_PIG B5UA80_PIG ----------------------------------------------DSLISTQNVVGLN- Q1A729_PIG Q1A729_PIG ----------------------------------------------DSLISTQNVVGLN- A4IIM7_XENTR A4IIM7_XENTR ----------------------------------------------DTLISAQNVSLSV- B7ZS63_XENLA B7ZS63_XENLA ----------------------------------------------DTLISAQNVSLSV- FOXO3_XENLA FOXO3_XENLA ----------------------------------------------DTLISAQNVSLSV- Q4SV53_TETNG Q4SV53_TETNG ----------------------------------------------DSLANMTGVGNLT- Q90YK2_XIPMA Q90YK2_XIPMA ----------------------------------------------ESLANMNGVSNFT- Q4REI0_TETNG Q4REI0_TETNG ----------------------------------------------DSRLTPTQNGNKN- Q5I0F7_DANRE Q5I0F7_DANRE ----------------------------------------------DSHLISSQNANLT- FOXO6_HUMAN FOXO6_HUMAN ----------------------------------------------DSALPPPPPGLAG- FOXO6_MOUSE FOXO6_MOUSE ----------------------------------------------DSALPPPPPGLAG- Q5RJI9_MOUSE Q5RJI9_MOUSE TQPCLRHPRAWLGRRPLTRAGCRAEGHPTQPGCPGPVPMGPLSSHPDPRVPTPPTQLHGR Q4T8Y3_TETNG Q4T8Y3_TETNG ----------------------------------------------DSSL---------- A5PF57_DANRE A5PF57_DANRE ------------------------------------------------------------ B4F6Q7_DANRE B4F6Q7_DANRE ----------------------------------------------DGSLSQGVGMGMG- MATCH CONSENSUS ????????????????????????????????????????????????????????????

B3UYC2_BRAFL B3UYC2_BRAFL GMTQSMTMSQTQTNAGR-LG----------------YR-ETVI--- Q4S8Z6_TETNG Q4S8Z6_TETNG ---------------VK-T-----------------TA-HSWV--- A3RK75_DANRE A3RK75_DANRE ----------------KTST-------------------HNWVSG- FOXO1_XENLA FOXO1_XENLA --------------VTT-TT-------------------HSWVSG- FOXO1_XENTR FOXO1_XENTR --------------VTT-TT-------------------HSWVSG- Q9W7F9_CHICK Q9W7F9_CHICK --------------VKT-TT-------------------HSWVSG- FOXO1_HUMAN FOXO1_HUMAN --------------VKT-TT-------------------HSWVSG- FOXO1_SPETR FOXO1_SPETR --------------VKT-TT-------------------HSWVSG- A4L7N3_PIG A4L7N3_PIG --------------VKT-TT-------------------HSWVSG- Q8MK69_PIG Q8MK69_PIG --------------VKT-TT-------------------HSWVSG- Q9ES26_RAT Q9ES26_RAT ---------------------------------------------- Q9WVH5_MOUSE Q9WVH5_MOUSE --------------VKT-TT-------------------HSWVSG- Q8BPP2_MOUSE Q8BPP2_MOUSE --------------VKT-TT-------------------HSWVSG- Q9JJW4_MOUSE Q9JJW4_MOUSE --------------VKT-TT-------------------HSWVSG- FOXO1_MOUSE FOXO1_MOUSE --------------VKT-TT-------------------HSWVSG- Q4RFQ3_TETNG Q4RFQ3_TETNG --------------AKT-TT-------------------HSWVSG- A3RK74_DANRE A3RK74_DANRE --------------VKT-TT-------------------HSWVSG- B1AUT2_MOUSE B1AUT2_MOUSE ---------------------------------------------- B1AUT3_MOUSE B1AUT3_MOUSE ---------------------------------------------- FOXO4_MOUSE FOXO4_MOUSE ---------------------------------------------- A6QLP0_BOVIN A6QLP0_BOVIN ---------------------------------------------- B4DTB6_HUMAN B4DTB6_HUMAN ---------------------------------------------- A6NID2_HUMAN A6NID2_HUMAN ---------------------------------------------- A8MXF0_HUMAN A8MXF0_HUMAN ---------------------------------------------- FOXO4_HUMAN FOXO4_HUMAN ---------------------------------------------- B7WPJ7_HUMAN B7WPJ7_HUMAN ---------------------------------------------- B3DGQ4_DANRE B3DGQ4_DANRE ---------GNFTGTKQ-SN-------------------HSWVPG- Q5TYS1_DANRE Q5TYS1_DANRE ---------GNFTGTKQ-SN-------------------HSWVPG- Q9W7F8_DANRE Q9W7F8_DANRE ---------GNFTGTKQ-SN-------------------HSWVPG- B4E1P9_HUMAN B4E1P9_HUMAN ---------------------------------------------- Q9WVH4_MOUSE Q9WVH4_MOUSE --------VGNFTGAKQ-AS----------------S--QSWVPG- FOXO3_HUMAN FOXO3_HUMAN --------VGNFTGAKQ-AS----------------S--QSWVPG- B4DVZ6_HUMAN B4DVZ6_HUMAN --------VGNFTGAKQ-AS----------------S--QSWVPG- Q68DV3_HUMAN Q68DV3_HUMAN --------VGNFTGAKQ-AS----------------S--QSWVPG- A2A1E7_PIG A2A1E7_PIG ---------------------------------------------- B5UA80_PIG B5UA80_PIG --------VGSFTGAKQ-AS----------------S--QSWVPG- Q1A729_PIG Q1A729_PIG --------VGSFTGAKQ-A--------------------------- A4IIM7_XENTR A4IIM7_XENTR ---------GSFTGAKQ-TS----------------S--QSWVPG- B7ZS63_XENLA B7ZS63_XENLA ---------GSFTGAKQ-TS----------------S--QSWVPG- FOXO3_XENLA FOXO3_XENLA ---------GSFTGAKQ-TS----------------S--QSWVPG- Q4SV53_TETNG Q4SV53_TETNG ---------------ST-KQ----------------AS-QTWVP-- Q90YK2_XIPMA Q90YK2_XIPMA ------------------------------------STKHSWVPG- Q4REI0_TETNG Q4REI0_TETNG --------SGSYSGSKP-AA----------------P--RSWVPS- Q5I0F7_DANRE Q5I0F7_DANRE --------SGSFSRTKR-T-----------------SS-QSWVPG- FOXO6_HUMAN FOXO6_HUMAN ----------------A-PP----------------PN-QSWVPG- FOXO6_MOUSE FOXO6_MOUSE ---------------AP-PP----------------N--QSWVPG- Q5RJI9_MOUSE Q5RJI9_MOUSE IQEATPAQLETSLRAER-RGRLEGALRHLAIPARGLEVWEGWLKSG Q4T8Y3_TETNG Q4T8Y3_TETNG ---------------------------------------------- A5PF57_DANRE A5PF57_DANRE ---------------------------------------------- B4F6Q7_DANRE B4F6Q7_DANRE ----LGMGMGVFAGPQQ-SH----------------NS-QSWVPG- MATCH CONSENSUS ??????????????????????????????????????????????


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