Alignment of the gene Family HBG058897 of HOVERGEN

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Threshold: 50% 80% 100%
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Isoforms are ON
Q6NYW2_DANRE Q6NYW2_DANRE ------------------------------------------------------------ Q7ZVN8_DANRE Q7ZVN8_DANRE ------------------------------------------------------------ A2ATY1_DANRE A2ATY1_DANRE ------------------------------------------------------------ Q5U3H7_DANRE Q5U3H7_DANRE ------------------------------------------------------------ Q6GQ14_XENLA Q6GQ14_XENLA ------------------------------------------------------------ Q7ZXI0_XENLA Q7ZXI0_XENLA ------------------------------------------------------------ Q4RYM9_TETNG Q4RYM9_TETNG ------------------------------------------------------------ B4DSJ4_HUMAN B4DSJ4_HUMAN ------------------------------------------------------------ Q8IVR6_HUMAN Q8IVR6_HUMAN ------------------------------------------------------------ Q4R8H7_MACFA Q4R8H7_MACFA ------------------------------------------------------------ B2R7A1_HUMAN B2R7A1_HUMAN ------------------------------------------------------------ Q6P991_HUMAN Q6P991_HUMAN ------------------------------------------------------------ Q8NEA7_HUMAN Q8NEA7_HUMAN ------------------------------------------------------------ PPM1D_HUMAN PPM1D_HUMAN ------------------------------------------------------------ Q53XP4_HUMAN Q53XP4_HUMAN ------------------------------------------------------------ B1WCA0_RAT B1WCA0_RAT ------------------------------------------------------------ B1B0B1_MOUSE B1B0B1_MOUSE ------------------------------------------------------------ Q3TAP1_MOUSE Q3TAP1_MOUSE --ARDSTGPALADKSRHHAPPPTAAGTASSSLSASSKINNSWPASGECVSRLGIRRAAWE Q3TZJ9_MOUSE Q3TZJ9_MOUSE PLARDSTGPALADKSRHHAPPPTAAGTASSSLSASSKINNSWPASGECVSRLGIRRAAWE PPM1D_MOUSE PPM1D_MOUSE ------------------------------------------------------------ Q80WV2_MOUSE Q80WV2_MOUSE ------------------------------------------------------------ Q8R1N9_MOUSE Q8R1N9_MOUSE ------------------------------------------------------------ B1B0B0_MOUSE B1B0B0_MOUSE ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q6NYW2_DANRE Q6NYW2_DANRE --------MDGIFSCRASIYYDQGGRKYMEDLVTMKQEDEPSEDELDAAERGEVEA---- Q7ZVN8_DANRE Q7ZVN8_DANRE --------MDGIFSCRASIYYDQGGRKYMEDLVTMKQEDEPSEDELDAAERGEVEA---- A2ATY1_DANRE A2ATY1_DANRE ------MDMNCDLSLRVSVFSEQGGRKYMEDLTEVIVELEPTEDELQAAGHADPKP---- Q5U3H7_DANRE Q5U3H7_DANRE ------MDMNCDLSLRVSVFSEQGGRKYMEDLTEVIVELEPTEDELQAAGHADPKP---- Q6GQ14_XENLA Q6GQ14_XENLA --------METPFSLRVSVSSDQGGRKYMEDVTQILVEPEPGEDELPWSEGEEETP---- Q7ZXI0_XENLA Q7ZXI0_XENLA --------MEIPFTLRVSVSSDQGGRKYMEDVIQIVVGPEPGEDELPWSEEEEGTP---- Q4RYM9_TETNG Q4RYM9_TETNG --------------LRVSVFTDQGGRKYMEDVTEVIVEPEPGEDEPKSDEPGDSSAVEFM B4DSJ4_HUMAN B4DSJ4_HUMAN ------------------------------------------------------------ Q8IVR6_HUMAN Q8IVR6_HUMAN --------MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQP---- Q4R8H7_MACFA Q4R8H7_MACFA ----------------------------MEDVTQIVVEPEPTAEEKPSPRRSLSQP---- B2R7A1_HUMAN B2R7A1_HUMAN --------MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQP---- Q6P991_HUMAN Q6P991_HUMAN --------MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQP---- Q8NEA7_HUMAN Q8NEA7_HUMAN --------MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQP---- PPM1D_HUMAN PPM1D_HUMAN --------MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQP---- Q53XP4_HUMAN Q53XP4_HUMAN --------MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQP---- B1WCA0_RAT B1WCA0_RAT --------MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPAAEDKPAPVPRRALG---- B1B0B1_MOUSE B1B0B1_MOUSE --------MA-------------------------------------------------- Q3TAP1_MOUSE Q3TAP1_MOUSE RRDPGQPAMAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPAAEDKPAPVPRRALG---- Q3TZJ9_MOUSE Q3TZJ9_MOUSE RRDPGQPAMAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPAAEDKPAPVPRRALG---- PPM1D_MOUSE PPM1D_MOUSE --------MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPAAEDKPAPVPRRALG---- Q80WV2_MOUSE Q80WV2_MOUSE --------MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPAAEDKPAPVPRRALG---- Q8R1N9_MOUSE Q8R1N9_MOUSE --------MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPAAEDKPAPVPRRALG---- B1B0B0_MOUSE B1B0B0_MOUSE --------MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPAAEDKPAPVPRRALG---- MATCH CONSENSUS ????????M????????S????QGGRKYMED?????VE?EP???????????????????

Q6NYW2_DANRE Q6NYW2_DANRE ---------------------PAKDPNPDASIQDSIPGSITVTYIQDDEPISTLQHASMP Q7ZVN8_DANRE Q7ZVN8_DANRE ---------------------PAKDPNPDASIQDSIPGSITVTYIQDNEPISTLQHASMP A2ATY1_DANRE A2ATY1_DANRE ----------------------DQEPVSDSEPPDCSNNPLPVLITWRNPLSTEEADGTDE Q5U3H7_DANRE Q5U3H7_DANRE ----------------------DQEPVSDSEPPDCSNNPLPVLIAWRNPLSTEEADGTDE Q6GQ14_XENLA Q6GQ14_XENLA ------------------------------------------------------------ Q7ZXI0_XENLA Q7ZXI0_XENLA ------------------------------------------------------------ Q4RYM9_TETNG Q4RYM9_TETNG TSSATEDKHDRQTRKTDSSSFVSDAPYETVQTENEGTTAGNAVCG--GRSPPP-----PE B4DSJ4_HUMAN B4DSJ4_HUMAN ------------------------------------------------------------ Q8IVR6_HUMAN Q8IVR6_HUMAN ---------------------LPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPA Q4R8H7_MACFA Q4R8H7_MACFA ---------------------LSLRPSPPAPAGGEVSGKGPAVAAREARDPPPDAGASPA B2R7A1_HUMAN B2R7A1_HUMAN ---------------------LPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPA Q6P991_HUMAN Q6P991_HUMAN ---------------------LPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPA Q8NEA7_HUMAN Q8NEA7_HUMAN ---------------------LPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPA PPM1D_HUMAN PPM1D_HUMAN ---------------------LPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPA Q53XP4_HUMAN Q53XP4_HUMAN ---------------------LPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPA B1WCA0_RAT B1WCA0_RAT ---------------------LPATPS---LVGVGPSGKGPAA----ARDPAPDAAASLP B1B0B1_MOUSE B1B0B1_MOUSE ------------------------------------------------------------ Q3TAP1_MOUSE Q3TAP1_MOUSE ---------------------LPATPT---LAGVGPSEKGPAA----ARDPAPDAAASLP Q3TZJ9_MOUSE Q3TZJ9_MOUSE ---------------------LPATPT---LAGVGPSEKGPAA----ARDPAPDAAASLP PPM1D_MOUSE PPM1D_MOUSE ---------------------LPATPT---LAGVGPSEKGPAA----ARDPAPDAAASLP Q80WV2_MOUSE Q80WV2_MOUSE ---------------------LPATPT---LAGVGPSEKGPMA----ARDPAPDAAASLP Q8R1N9_MOUSE Q8R1N9_MOUSE ---------------------LPATPT---LAGVGPSEKGPAA----ARDPAPDAAASLP B1B0B0_MOUSE B1B0B0_MOUSE ---------------------LPATPT---LAGVGPSEKGPAA----ARDPAPDAAASLP MATCH CONSENSUS ?????????????????????????P??????????????????????????????????

Q6NYW2_DANRE Q6NYW2_DANRE SSVHAR----RPRAVALFAVFDGHGGPDAARFARDHLWDHIKKQRGFWSEDDDEVCAALR Q7ZVN8_DANRE Q7ZVN8_DANRE SSVHAR----RPRAVALFAVFDGHGGPDAARFARDHLWDHIKKQRGFWSEDDDEVCAALR A2ATY1_DANRE A2ATY1_DANRE PGTQPAAAD-SRRSVAFFAVFDGHGGREAAMFARDHLWDFLKKQRGFWSKDYRKVCSAIR Q5U3H7_DANRE Q5U3H7_DANRE PGTQPAAAD-SRRSVAFFAVFDGHGGREAAMFARDHLWDFLKKQRGFWSKDYRKVCSAIR Q6GQ14_XENLA Q6GQ14_XENLA -AKNCRRESGSRQTVAFFAVYDGHGGREAAHFARDRLWGHISKQKGFLSRDPEEVCGAIR Q7ZXI0_XENLA Q7ZXI0_XENLA -AKNCRSE--NRQTVAFFAVYDGHGGREAAHFARDHLWAHIRKQKGFLSRDPEEVCGAIR Q4RYM9_TETNG Q4RYM9_TETNG PSAAGR----SRRSVAFFAVFDGHGGCEAAQFARDYLWEFVKKQRGFWSDCDREVCSALR B4DSJ4_HUMAN B4DSJ4_HUMAN ------------------------------------------------------------ Q8IVR6_HUMAN Q8IVR6_HUMAN PSRCCR----RRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIR Q4R8H7_MACFA Q4R8H7_MACFA PSRCCR----RRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIR B2R7A1_HUMAN B2R7A1_HUMAN PSRCCR----RRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIR Q6P991_HUMAN Q6P991_HUMAN PSRCCR----RRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIR Q8NEA7_HUMAN Q8NEA7_HUMAN PSRCCR----RRSSVAFFAVCDGHGGREAAQFAREHFWGFIKKQKGFTSSEPAKVCAAIR PPM1D_HUMAN PPM1D_HUMAN PSRCCR----RRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIR Q53XP4_HUMAN Q53XP4_HUMAN PSRCCR----RRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIR B1WCA0_RAT B1WCA0_RAT AGRCCR----RRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIR B1B0B1_MOUSE B1B0B1_MOUSE -------------------------------LAR-------------------------- Q3TAP1_MOUSE Q3TAP1_MOUSE AGRCCR----RRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIR Q3TZJ9_MOUSE Q3TZJ9_MOUSE AGRCCR----RRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIR PPM1D_MOUSE PPM1D_MOUSE AGRCCR----RRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIR Q80WV2_MOUSE Q80WV2_MOUSE AGRCCR----RRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIR Q8R1N9_MOUSE Q8R1N9_MOUSE AGRCCR----RRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIR B1B0B0_MOUSE B1B0B0_MOUSE AGRCCR----RRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIR MATCH CONSENSUS ?????R?????R??VAFFAV?DGHGG?EAA?FAR?HLW???KKQ?GF?S?????VC?A?R

Q6NYW2_DANRE Q6NYW2_DANRE KGFITCHHAMWKKLPEWPKTVTGLPSTSGTTASIVVLRRDRMYVAHVGDSAVVLGVQDHP Q7ZVN8_DANRE Q7ZVN8_DANRE KGFITCHHAMWKKLPEWPETVTGLPSTSGTTASIVVLRRDRMYVAHVGDSAVVLGVQDHP A2ATY1_DANRE A2ATY1_DANRE KGFIACHHAMWKKLPEWPKTLTGLPSTSGTTASVVVIRGDHMFVAHVGDSSVVLGVREDP Q5U3H7_DANRE Q5U3H7_DANRE KGFIACHHAMWKKLPEWPKTLTGLPSTSGTTASVVVIRGDHMFVAHVGDSSVVLGVREDP Q6GQ14_XENLA Q6GQ14_XENLA KGFVACHHAMWKKLPEWPKTMTGLPSTSGTTASVVIIRGNKMYVAHVGDSGVVFGLQNGT Q7ZXI0_XENLA Q7ZXI0_XENLA KGFVACHHAMWKKLPEWPKTMTGLPSTSGTTATVVIIRGNKMYVAHVGDSGVVFGLQNGS Q4RYM9_TETNG Q4RYM9_TETNG KGFVACHHAMWKKLPEWPKTLTGLPSTSGTTASIVVIRGDRMYVAHVGDSAVVLGVQDDP B4DSJ4_HUMAN B4DSJ4_HUMAN ---------MWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDP Q8IVR6_HUMAN Q8IVR6_HUMAN KGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDP Q4R8H7_MACFA Q4R8H7_MACFA KGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDP B2R7A1_HUMAN B2R7A1_HUMAN KGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDP Q6P991_HUMAN Q6P991_HUMAN KGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDP Q8NEA7_HUMAN Q8NEA7_HUMAN KGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDP PPM1D_HUMAN PPM1D_HUMAN KGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDP Q53XP4_HUMAN Q53XP4_HUMAN KGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDP B1WCA0_RAT B1WCA0_RAT KGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDP B1B0B1_MOUSE B1B0B1_MOUSE --------------SEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDP Q3TAP1_MOUSE Q3TAP1_MOUSE KGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDP Q3TZJ9_MOUSE Q3TZJ9_MOUSE KGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDP PPM1D_MOUSE PPM1D_MOUSE KGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDP Q80WV2_MOUSE Q80WV2_MOUSE KGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDP Q8R1N9_MOUSE Q8R1N9_MOUSE KGFLACHLAMWKKL-EWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDP B1B0B0_MOUSE B1B0B0_MOUSE KGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDP MATCH ***:*:***********::*::* :*:*******.**:*::: . CONSENSUS KGF?ACH?AMWKKL?EWPKT?TGLPSTSGTTASVV?IRG??MYVAHVGDS?VVLG?QDDP

Q6NYW2_DANRE Q6NYW2_DANRE SEEFIRAVEITQDHKPDLPKERERIEGLGGSVIKKSGVNRVVWKRPRLTHNGPVRRSTVI Q7ZVN8_DANRE Q7ZVN8_DANRE SEEFIRAVEITQDHKPDLPKVRERIEGLGGSVIKKSGVNRVVWKRPRLTHNGPVRRSTVI A2ATY1_DANRE A2ATY1_DANRE SDKVIKAVEVTQDHKPELPKEKQRIEGLGGSVVKKSGVNRVVWKRPRLSHNGPVRRSTPI Q5U3H7_DANRE Q5U3H7_DANRE SDKVIKAVEVTQDHKPELPKEKQRIEGLGGSVVKKSGVNRVVWKRPRLSHNGPVRRSTPI Q6GQ14_XENLA Q6GQ14_XENLA RDT-LKAVEVTQDHKPELPRERERIEGLGGSVINKCGVNRVVWKRPRLTHNGPVRRSTVI Q7ZXI0_XENLA Q7ZXI0_XENLA RDS-LKAVEATQDHKPELPRERERIEGLGGSVINKSGVNRVVWKRPRLTHNGPVRRSTVI Q4RYM9_TETNG Q4RYM9_TETNG SLPFIRAVEVTQDHKPELPRERERIEGLGGSVIKKSGVNRVVWKRPRLSHNGPVRRSTVI B4DSJ4_HUMAN B4DSJ4_HUMAN KDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVI Q8IVR6_HUMAN Q8IVR6_HUMAN KDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVI Q4R8H7_MACFA Q4R8H7_MACFA KDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVI B2R7A1_HUMAN B2R7A1_HUMAN KDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVI Q6P991_HUMAN Q6P991_HUMAN KDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVI Q8NEA7_HUMAN Q8NEA7_HUMAN KDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVI PPM1D_HUMAN PPM1D_HUMAN KDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVI Q53XP4_HUMAN Q53XP4_HUMAN KDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVI B1WCA0_RAT B1WCA0_RAT KDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHSGPVRRSTVI B1B0B1_MOUSE B1B0B1_MOUSE KDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHSGPVRRSTVI Q3TAP1_MOUSE Q3TAP1_MOUSE KDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHSGPVRRSTVI Q3TZJ9_MOUSE Q3TZJ9_MOUSE KDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHSGPVRRSTVI PPM1D_MOUSE PPM1D_MOUSE KDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHSGPVRRSTVI Q80WV2_MOUSE Q80WV2_MOUSE KDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHSGPVRRSTVI Q8R1N9_MOUSE Q8R1N9_MOUSE KDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHSGPVRRSTVI B1B0B0_MOUSE B1B0B0_MOUSE KDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHSGPVRRSTVI MATCH ::*** ******:**: ::*********::*.************:*.******* * CONSENSUS ?D?F?RAVEVTQDHKPELPKERERIEGLGGSV??KSGVNRVVWKRPRLTH?GPVRRSTVI

Q6NYW2_DANRE Q6NYW2_DANRE DQIPFLAVARALGDLWSYDFYSGEFVVSPEPDTAVIKLDLKQHRYIILGSDGLWNMVSPQ Q7ZVN8_DANRE Q7ZVN8_DANRE DQIPFLAVARALGDLWSYDFYSGEFVVSPEPDTAVIKLDLKQHRYIILGSDGLWNMVSPQ A2ATY1_DANRE A2ATY1_DANRE DQIPFLAVARALGDLWSYDFYSGEFVVSPEPDTSVVTLDPRRHRYIIVGSDGLWNMVPPQ Q5U3H7_DANRE Q5U3H7_DANRE DQIPFLAVARALGDLWSYDFYSGEFVVSPEPDTSVVTLDPRRHRYIIVGSGGLWNMVPPQ Q6GQ14_XENLA Q6GQ14_XENLA DQIPFLAVARALGDLWSYDFYSGEFVVSPEPDTSVHTIDPQKHKFIIIGSDGLWNMVSAQ Q7ZXI0_XENLA Q7ZXI0_XENLA DQIPFLAVARALGDLWSYDFYSGEFVVSPEPDTSVHTIDPQKHKLIIIGSDGLWNMVSAQ Q4RYM9_TETNG Q4RYM9_TETNG DQIPFLAVARALGDLWSYDFYSGEFVVSPEPDTSVVTLDPKKHRYIVLGSDGLWNMVPPQ B4DSJ4_HUMAN B4DSJ4_HUMAN DQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQ Q8IVR6_HUMAN Q8IVR6_HUMAN DQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQ Q4R8H7_MACFA Q4R8H7_MACFA DQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQ B2R7A1_HUMAN B2R7A1_HUMAN DQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQ Q6P991_HUMAN Q6P991_HUMAN DQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPQQ Q8NEA7_HUMAN Q8NEA7_HUMAN DQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQ PPM1D_HUMAN PPM1D_HUMAN DQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQ Q53XP4_HUMAN Q53XP4_HUMAN DQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQ B1WCA0_RAT B1WCA0_RAT DQIPFLAVARALGDLWSYDFFSGKFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMVPPQ B1B0B1_MOUSE B1B0B1_MOUSE DQIPFLAVARALGDLWSYDFFSGKFVVSPEPDTSVHTLDPRKHKYIILGSDGLWNMVPP- Q3TAP1_MOUSE Q3TAP1_MOUSE DQIPFLAVARALGDLWSYDFFSGKFVVSPEPDTSVHTLDPRKHKYIILGSDGLWNMVPPQ Q3TZJ9_MOUSE Q3TZJ9_MOUSE DQIPFLAVARALGDLWSYDFFSGKFVVSPEPDTSVHTLDPRKHKYIILGSDGLWNMVPPQ PPM1D_MOUSE PPM1D_MOUSE DQIPFLAVARALGDLWSYDFFSGKFVVSPEPDTSVHTLDPRKHKYIILGSDGLWNMVPPQ Q80WV2_MOUSE Q80WV2_MOUSE DQIPFLAVARALGDLWSYDFFSGKFVVSPEPDTSVHTLDPRKHKYIILGSDGLWNMVPPQ Q8R1N9_MOUSE Q8R1N9_MOUSE DQIPFLAVARALGDLWSYDFFSGKFVVSPEPDTSVHTLDPRKHKYIILGSDGLWNMVPPQ B1B0B0_MOUSE B1B0B0_MOUSE DQIPFLAVARALGDLWSYDFFSGKFVVSPEPDTSVHTLDPRKHKYIILGSDGLWNMVPPQ MATCH ********************:**:*********:* .:* ::*: *::**.*****:. CONSENSUS DQIPFLAVARALGDLWSYDF?SG?FVVSPEPDTSV?TLDP?KH?YIILGSDGLWNM?PPQ

Q6NYW2_DANRE Q6NYW2_DANRE EAVSICQDNDEAKAKNQKGNVSNAVLLVNHALLRWRQRMLRADNTSAIVISL-ESFGTSS Q7ZVN8_DANRE Q7ZVN8_DANRE EAVSICQDNDEAKAKNQKGNVSNAVLLVNHALLRWRQRMLRADNTSAIVISL-ESFGTSS A2ATY1_DANRE A2ATY1_DANRE EAVTVCQSHDEA---VAPFGMSVARRLGCHALMRWRQRMLRADNTSVIVIAL-PEPGKPH Q5U3H7_DANRE Q5U3H7_DANRE EAVTVCQSHDEA---VAPFGMSVARRLGCHALMRWRQRMLRADNTSVIVIAL-PEPGKPH Q6GQ14_XENLA Q6GQ14_XENLA DAISMCQEQ-ERACVTGDHGQTCAKMLVSRALTQWRQRMLRADNTSVVVISISPLTEKPR Q7ZXI0_XENLA Q7ZXI0_XENLA DAISMCQEQ-EKACATGDHGQTCAKTLVSRALTQWRQRMLRADNTSVVVISISPLTEKPR Q4RYM9_TETNG Q4RYM9_TETNG EAISMCQNNDEA-MVSEARTSSCPQ----------KKRVIVFDSYKII------------ B4DSJ4_HUMAN B4DSJ4_HUMAN DAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQG Q8IVR6_HUMAN Q8IVR6_HUMAN DAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQG Q4R8H7_MACFA Q4R8H7_MACFA DAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQG B2R7A1_HUMAN B2R7A1_HUMAN DAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQG Q6P991_HUMAN Q6P991_HUMAN DAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQG Q8NEA7_HUMAN Q8NEA7_HUMAN DAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQG PPM1D_HUMAN PPM1D_HUMAN DAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQG Q53XP4_HUMAN Q53XP4_HUMAN DAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQG B1WCA0_RAT B1WCA0_RAT DAISMCQDQEEKKYLMGEQGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQG B1B0B1_MOUSE B1B0B1_MOUSE ------------------------------------------------------------ Q3TAP1_MOUSE Q3TAP1_MOUSE DAISMCQDQEEKKYLMGEQGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQG Q3TZJ9_MOUSE Q3TZJ9_MOUSE DAISMCQDQEEKKYLMGEQGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQG PPM1D_MOUSE PPM1D_MOUSE DAISMCQDQEEKKYLMGEQGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQG Q80WV2_MOUSE Q80WV2_MOUSE DAISMCQDQEEKKYLMGEQGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQG Q8R1N9_MOUSE Q8R1N9_MOUSE DAISMCQDQEEKKYLMGEQGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQG B1B0B0_MOUSE B1B0B0_MOUSE DAISMCQDQEEKKYLMGEQGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQG MATCH CONSENSUS ?A?S?CQ???E????????G?S?A??LV??AL?RWRQRMLRADNTS?IVI???P??????

Q6NYW2_DANRE Q6NYW2_DANRE ECLPPYETVYNLQGT-------KCGAVSKPCTNSLQTQVPDAPVQ--------PILEQKN Q7ZVN8_DANRE Q7ZVN8_DANRE ECLPPYETVYNLQGT-------KCGAVSKPCTNSLQTQVPDAPVQ--------PILEQKN A2ATY1_DANRE A2ATY1_DANRE LPMHRDEVILSLAEGPHCDP-----ATGSRSNTPLIKTP--DPDLSSASSESLPALERRN Q5U3H7_DANRE Q5U3H7_DANRE LPMHRDEVILSLAEGPHCDP-----ATGSRSNTPLIKTP--DPDLSSASSESLPALERRN Q6GQ14_XENLA Q6GQ14_XENLA SCVGE-ELFLNLAENPSYNSQDMCHLSSTPCSTPPIKFLDEDSWWKLSFSEPLPTLVRRN Q7ZXI0_XENLA Q7ZXI0_XENLA SCVGE-ELFLNLAENPCYNNQDMSHLSSTPCSTP-IKFLDEDSWWKLTFSEPLPSLVYRS Q4RYM9_TETNG Q4RYM9_TETNG ---------------GPYRRHVGCQTLGSWSATPCC------------------------ B4DSJ4_HUMAN B4DSJ4_HUMAN NFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVKDF--------------------- Q8IVR6_HUMAN Q8IVR6_HUMAN NFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVKDF--------------------- Q4R8H7_MACFA Q4R8H7_MACFA NFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVKSLEEDPWPRLNSKDHIPALVRSN B2R7A1_HUMAN B2R7A1_HUMAN NFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVKSLEEDPWPRVNSKDHIPALVRSN Q6P991_HUMAN Q6P991_HUMAN NFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVKSLEEDPWPRVNSKDHIPALVRSN Q8NEA7_HUMAN Q8NEA7_HUMAN NFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVKSLEEDPWPRVNSKDHIPALVRSN PPM1D_HUMAN PPM1D_HUMAN NFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVKSLEEDPWPRVNSKDHIPALVRSN Q53XP4_HUMAN Q53XP4_HUMAN NFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVKSLEEDPWPRVNSKDHIPALVRSN B1WCA0_RAT B1WCA0_RAT NFTNEDELFLNLTDSPTYNSQETCVMTPSPSSTPPVKSLEEDPWPRLNSKDHIPALVRSN B1B0B1_MOUSE B1B0B1_MOUSE ------------------------------------------------------------ Q3TAP1_MOUSE Q3TAP1_MOUSE NFTNEDELFLNLTDSPTYNSQETCVMTSSPSSTPPIKSPEEDAWPRLSSKDHIPALVRSN Q3TZJ9_MOUSE Q3TZJ9_MOUSE NFTNEDELFLNLTDSPTYNSQETCVMTSSPSSTPPIKSPEEDAWPRLSSKDHIPALVRSN PPM1D_MOUSE PPM1D_MOUSE NFTNEDELFLNLTDSPTYNSQETCVMTSSPSSTPPIKSPEEDAWPRLSSKDHIPALVRSN Q80WV2_MOUSE Q80WV2_MOUSE NFTNEDELFLNLTDSPTYNSQETCVMTSSPSSTPPIKSPEEDAWPRLSSKDHIPALVRSN Q8R1N9_MOUSE Q8R1N9_MOUSE NFTNEDELFLNLTDSPTYNSQETCVMTSSPSSTPPIKSPEEDAWPRLSSKDHIPALVRSN B1B0B0_MOUSE B1B0B0_MOUSE NFTNEDELFLNLTDSPTYNSQETCVMTSSPSSTPPIKSPEEDAWPRLSSKDHIPALVRSN MATCH CONSENSUS ??????E??LNL???P???????C?????P??TP??K????????????????P?L????

Q6NYW2_DANRE Q6NYW2_DANRE NSSGA--------------SIIFESSDSLTNSEDLP------CNDLLENGASCDRTPTG- Q7ZVN8_DANRE Q7ZVN8_DANRE NSSGA--------------SIIFESSDSLTNSEDLP------CNDLLENGASCDRTPTG- A2ATY1_DANRE A2ATY1_DANRE GLS----------------GVSLCAEA--PLEENLP-------YIELADKTDLTVCPSGG Q5U3H7_DANRE Q5U3H7_DANRE GLS----------------GVSLCAEA--PLEENLP-------YIELADKTDLTVCPSGG Q6GQ14_XENLA Q6GQ14_XENLA AFSSKW---SSEAEKSKADIYSPTLEDVGLSESKGS------LSQWPSDDPSSCLFPGSS Q7ZXI0_XENLA Q7ZXI0_XENLA AFSSKCEKWSSETGKSRADISSPTLGDVEKSESKG------KLSQWPSDNPSTCLFPGSS Q4RYM9_TETNG Q4RYM9_TETNG ---------------GGARGCCVPTTQ--------------------------------- B4DSJ4_HUMAN B4DSJ4_HUMAN -------------------GFELDSRK--------------------------------- Q8IVR6_HUMAN Q8IVR6_HUMAN -------------------GFELDSRK--------------------------------- Q4R8H7_MACFA Q4R8H7_MACFA AFSENFLEVSAEIARGNVQGVVIPSKDPEPLEENCAKALTLRIHDSLNNSLPVGLVPTNS B2R7A1_HUMAN B2R7A1_HUMAN AFSENFLEVSAEIARENVQGVVIPSKDPEPLEENCAKALTLRIHDSLNNSLPIGLVPTNS Q6P991_HUMAN Q6P991_HUMAN AFSENFLEVSAEIARENVQGVVIPSKDPEPLEENCAKALTLRIHDSLNNSLPIGLVPTNS Q8NEA7_HUMAN Q8NEA7_HUMAN AFSENFLEVSAEIARENVQGVVIPSKDPEPLEENCAKALTLRIHDSLNNSLPIGLVPTNS PPM1D_HUMAN PPM1D_HUMAN AFSENFLEVSAEIARENVQGVVIPSKDPEPLEENCAKALTLRIHDSLNNSLPIGLVPTNS Q53XP4_HUMAN Q53XP4_HUMAN AFSENFLEVSAEIARENVQGVVIPSKDPEPLEENCAKALTLRIHDSLNNSLPIGLVPTNS B1WCA0_RAT B1WCA0_RAT AFSEKFLEVPAEIARGSIQTVVMTSKDSETLEENCPKALTLRIHDSLNNTLSVGLMPTNS B1B0B1_MOUSE B1B0B1_MOUSE ------------------------------------------------------------ Q3TAP1_MOUSE Q3TAP1_MOUSE AFSEKFLEVPAEIARGNIQTVVMTSKDSETLEENCPKALTLRIHDSLNNTLSVGLIPTNS Q3TZJ9_MOUSE Q3TZJ9_MOUSE AFSEKFLEVPAEIARGNIQTVVMTSKDSETLEENCPKALTLRIHDSLNNTLSVGLIPTNS PPM1D_MOUSE PPM1D_MOUSE AFSEKFLEVPAEIARGNIQTVVMTSKDSETLEENCPKALTLRIHDSLNNTLSVGLIPTNS Q80WV2_MOUSE Q80WV2_MOUSE AFSEKFLEVPAEIARGNIQTVVMTSKDSETLEENCPKALTLRIHDSLNNTLSVGLIPTNS Q8R1N9_MOUSE Q8R1N9_MOUSE AFSEKFLEVPAEIARGNIQTVVMTSKDSETLEENCPKALTLRIHDSLNNTLSVGLIPTNS B1B0B0_MOUSE B1B0B0_MOUSE AFSEKFLEVPAEIARGNIQTVVMTSKDSETLEENCPKALTLRIHDSLNNTLSVGLIPTNS MATCH CONSENSUS ??S?????????????????????????????????????????????????????P???

Q6NYW2_DANRE Q6NYW2_DANRE -------------------------------KRVLEDFSSSPVGKKP-RSSLTQSSLKES Q7ZVN8_DANRE Q7ZVN8_DANRE -------------------------------KRVLEDFSSSPVGKKP-RSSLTQSSLKES A2ATY1_DANRE A2ATY1_DANRE -------------------------------KRTLDTPLSSPVAKRPRRSPLA------- Q5U3H7_DANRE Q5U3H7_DANRE -------------------------------KRTPDTPLSSPVAKRPRRSPLA------- Q6GQ14_XENLA Q6GQ14_XENLA SAASSVGKTAKVQNSSQTKKTESERL--ASLKRTLEESNSAPAVKKLKRN-FPRNSTGQT Q7ZXI0_XENLA Q7ZXI0_XENLA PAASSDGKTATVQNSSQTRKTETERL--ASLKRTLEESNSGPAVKKLKRN-FPRNSMVPI Q4RYM9_TETNG Q4RYM9_TETNG ----------------------------------------ALLSLACRSLGASR------ B4DSJ4_HUMAN B4DSJ4_HUMAN ------------------------------------------------------------ Q8IVR6_HUMAN Q8IVR6_HUMAN ------------------------------------------------------------ Q4R8H7_MACFA Q4R8H7_MACFA TNTVMDQKNLKMSTPGQMKAQEIERTPPTNFKRTLEESNSGPLMKKHRRNGLSRSSGAQP B2R7A1_HUMAN B2R7A1_HUMAN TNTVTDQKNLKMSTPGQMKAQEIERTPPTNFKRTLEESNSGPLMKKHRRNGLSRSSGAQP Q6P991_HUMAN Q6P991_HUMAN TNTVMDQKNLKMSTPGQMKAQEIERTPPTNFKRTLEESNSGPLMKKHRRNGLSRSSGAQP Q8NEA7_HUMAN Q8NEA7_HUMAN TNTVMDQKNLKMSTPGQMKAQEIERTPPTNFKRTLEESNSGPLMKKHRRNGLSRSSGAQP PPM1D_HUMAN PPM1D_HUMAN TNTVMDQKNLKMSTPGQMKAQEIERTPPTNFKRTLEESNSGPLMKKHRRNGLSRSSGAQP Q53XP4_HUMAN Q53XP4_HUMAN TNTVMDQKNLKMSTPGQMKAQEIERTPPTNFKRTLEESNSGPLMKKHRRNGLSRSSGAQP B1WCA0_RAT B1WCA0_RAT TNTIMDQKNLKMSTPGQMKAQEVERTPPANFKRTLEESNSGPLMKKHRRNGLSRNSGAQA B1B0B1_MOUSE B1B0B1_MOUSE ------------------------------------------------------------ Q3TAP1_MOUSE Q3TAP1_MOUSE TNTIMDQKNLKMSTPGQMKAQEVERTPPANFKRTLEESNSGPLMKKHRRNGLSRSSGAQA Q3TZJ9_MOUSE Q3TZJ9_MOUSE TNTIMDQKNLKMSTPGQMKAQEVERTPPANFKRTLEESNSGPLMKKHRRNGLSRSSGAQA PPM1D_MOUSE PPM1D_MOUSE TNTIMDQKNLKMSTPGQMKAQEVERTPPANFKRTLKESNSGPLMKKHRRNGLSRSSGAQA Q80WV2_MOUSE Q80WV2_MOUSE TNTIMDQKNLKMSTPGQMKAQEVERTPPANFKRTLEESNSGPLMKKHRRNGLSRSSGAQA Q8R1N9_MOUSE Q8R1N9_MOUSE TNTIMDQKNLKMSTPGQMKAQEVERTPPANFKRTLEESNSGPLMKKHRRNGLSRSSGAQA B1B0B0_MOUSE B1B0B0_MOUSE TNTIMDQKNLKMSTPGQMKAQEVERTPPANFKRTLEESNSGPLMKKHRRNGLSRSSGAQA MATCH CONSENSUS ???????????????????????????????KR??????S?P??K???R???????????

Q6NYW2_DANRE Q6NYW2_DANRE S---CTSLQIPSTEPSARNNGDGSGQSENAQVLLQHGKTTVCVC Q7ZVN8_DANRE Q7ZVN8_DANRE S---CTSLQIPSTEPSARNNGDGSGQSENAQVLLQHGKTTVCVC A2ATY1_DANRE A2ATY1_DANRE ---PSSSRKRTTDRSLPRRNTTKSQKRTPSVSILQHRKAALCVC Q5U3H7_DANRE Q5U3H7_DANRE ---PSSSRKRTTDRSLPRRNTTKSQKRTPSVSILQHRKAALCVC Q6GQ14_XENLA Q6GQ14_XENLA ELPSTTPKRRSADRVTMRRSLRGQKKLGHP--LLQQHRKTICVC Q7ZXI0_XENLA Q7ZXI0_XENLA ESPSTTPKRRSADRVTMRRSLRGQKKLGHP--LLQQHRKTICAC Q4RYM9_TETNG Q4RYM9_TETNG ----TTCTRRRCCWTYPRCPSVPPPFCHVP--TLLSFR------ B4DSJ4_HUMAN B4DSJ4_HUMAN -------------------------------------------- Q8IVR6_HUMAN Q8IVR6_HUMAN -------------------------------------------- Q4R8H7_MACFA Q4R8H7_MACFA ASLPTTSQRKNSVKLTMRRRLRGQKKIGNP--LLHQHRKTVCVC B2R7A1_HUMAN B2R7A1_HUMAN ASLPTTSQRKNSVKLTMRRRLRGQKKIGNP--LLHQHRKTVCVC Q6P991_HUMAN Q6P991_HUMAN ASLPTTSQRKNSVKLTMRRRLRGQKKIGNP--LLHQHRKTVCVC Q8NEA7_HUMAN Q8NEA7_HUMAN ASLPTTSQRKNSVKLTMRRRLRGQKKIGNP--LLHQHRKTVCVC PPM1D_HUMAN PPM1D_HUMAN ASLPTTSQRKNSVKLTMRRRLRGQKKIGNP--LLHQHRKTVCVC Q53XP4_HUMAN Q53XP4_HUMAN ASLPTTSQRKNSVKLTMRRRLRGQKKIGNP--LLHQHRKTVCVC B1WCA0_RAT B1WCA0_RAT SSLPTASQRRHSVTLTMRRRLRGQKKMGNP--LLHQHRKTVCVC B1B0B1_MOUSE B1B0B1_MOUSE -------------------------------------------- Q3TAP1_MOUSE Q3TAP1_MOUSE SSLPTASQRRHSVKLTLRRRLRGQRKMGNP--LLHQHRKTVCVC Q3TZJ9_MOUSE Q3TZJ9_MOUSE SSLPTASQRRHSVKLTLRRRLRGQRKMGNP--LLHQHRKTVCVC PPM1D_MOUSE PPM1D_MOUSE SSLPTASQRRHSVKLTLRRRLRGQRKMGNP--LLHQHRKTVCVC Q80WV2_MOUSE Q80WV2_MOUSE SSLPTASQRRHSVKLTLRRRLRGQRKMGNP--LLHQHRKTVCVC Q8R1N9_MOUSE Q8R1N9_MOUSE SSLPTASQRRHSVKLTLRRRLRGQRKMGNP--LLHQHRKTVCVC B1B0B0_MOUSE B1B0B0_MOUSE SSLPTASQRRHSVKLTLRRRLRGQRKMGNP--LLHQHRKTVCVC MATCH CONSENSUS ?????????????????R???????????????L???????C?C


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