Alignment of the gene Family HBG059166 of HOVERGEN

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Isoforms are ON
Q5RHD8_DANRE Q5RHD8_DANRE ------------------------------------------------MAELESGDGDFP MYPN_HUMAN MYPN_HUMAN QDDSIEASTSISQLLRESYLAETRHRGNNERSRAEPSSNPCHFGSPSGAAEGGGGQDDLP MYPN_MOUSE MYPN_MOUSE QEDSIEASTSISQLLRESYLAETRHRGDNERSRAEPSSNPFHFSGPG--AAEGGGPEDLP B1H3I5_XENTR B1H3I5_XENTR ------------------------------------------------------------ B2RTX2_HUMAN B2RTX2_HUMAN --------------------------------MSGTSSHESFYDSLSDMQEESKNTDFFP B7ZMM5_HUMAN B7ZMM5_HUMAN --------------------------------MSGTSSHESFYDSLSDMQEESKNTDFFP PALLD_HUMAN PALLD_HUMAN --------------------------------MSGTSSHESFYDSLSDMQEESKNTDFFP PALLD_MOUSE PALLD_MOUSE --------------------------------MSETSSHDSFYDSLSDVQEEGKSADFFP PALLD_RAT PALLD_RAT ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RHD8_DANRE Q5RHD8_DANRE ELSAFLSQDEINLSLDLAREAMSD--VDDPNDPK--------PPVPTEHLPLYSETKDHA MYPN_HUMAN MYPN_HUMAN DLSAFLSQEELDESVNLARLAINYDPLEKADETQARKRL---SPDQMKHSPN-------- MYPN_MOUSE MYPN_MOUSE DLSAFLSQEELDESVNLARLAINHDPLERVDEAQARKRLSSDQTKHASK----------- B1H3I5_XENTR B1H3I5_XENTR ------------------------------------------------------------ B2RTX2_HUMAN B2RTX2_HUMAN GLSAFLSQEEINKSLDLARRAIADSETEDFDSEKEISQIFSTSPASLCEHPSHKETKLGE B7ZMM5_HUMAN B7ZMM5_HUMAN GLSAFLSQEEINKSLDLARRAIADSETEDFDSEKEISQIFSTSPASLCEHPSHKETKLGE PALLD_HUMAN PALLD_HUMAN GLSAFLSQEEINKSLDLARRAIADSETEDFDSEKEISQIFSTSPASLCEHPSHKETKLGE PALLD_MOUSE PALLD_MOUSE GLSAFLSQEEINKSLDLARRAIDSSETEDFDSEKEISQIFSKSPISLCETPSHEEPKSGK PALLD_RAT PALLD_RAT ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RHD8_DANRE Q5RHD8_DANRE LPDSASHSVDATSGKVASSQSRQNHLCAASESPEKFVCQKSIAPVYKQDRPRLIHGGLEL MYPN_HUMAN MYPN_HUMAN --LSFEPNFCQDNPRSPTSSKE-----SPQEAKRPQYCS--------------------- MYPN_MOUSE MYPN_MOUSE --PSFEPAFHQDSSRGPASPKD-----SPPETKRPQYSS--------------------- B1H3I5_XENTR B1H3I5_XENTR ------------------------------------------------------------ B2RTX2_HUMAN B2RTX2_HUMAN H-ASRRPQDNRSTPVQPLAEKQTKSISSPVSKRKPAMSPLLTRPSYIRSLRKAEKRGAKT B7ZMM5_HUMAN B7ZMM5_HUMAN H-ASRRPQDNRSTPVQPLAEKQTKSISSPVSKRKPAMSPLLTRPSYIRSLRKAEKRGAKT PALLD_HUMAN PALLD_HUMAN H-ASRRPQDNRSTPVQPLAEKQTKSISSPVSKRKPAMSPLLTRPSYIRSLRKAEKRGAKT PALLD_MOUSE PALLD_MOUSE QTSSERPQDSRRAPVQPLTGDQAERITSPGSKRKPGVSPLLASPSYIRSLRKAEKRGAKN PALLD_RAT PALLD_RAT ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RHD8_DANRE Q5RHD8_DANRE -----------NERAASATEFCSRAATFIEELSSIFK-GS----ARVDPQGDEDSSSPDS MYPN_HUMAN MYPN_HUMAN -------------ETQSKKVFLNKAADFIEELSSLFKSHSSKRIRPRACKNHKSKLESQN MYPN_MOUSE MYPN_MOUSE -------------ETQSKKVFLNKAADFIEELSSLFKAHSSKRIRPRACKNHKSKTESQN B1H3I5_XENTR B1H3I5_XENTR ------------------------------------------------------------ B2RTX2_HUMAN B2RTX2_HUMAN PSTNVKPKTPHQRKGGPQSQLCDKAANLIEELTSIFK-AA----KPRNRSPNGESSSPDS B7ZMM5_HUMAN B7ZMM5_HUMAN PSTNVKPKTPHQRKGGPQSQLCDKAANLIEELTSIFK-AA----KPRNRSPNGESSSPDS PALLD_HUMAN PALLD_HUMAN PSTNVKPKTPHQRKGGPQSQLCDKAANLIEELTSIFK-AA----KPRNRSPNGESSSPDS PALLD_MOUSE PALLD_MOUSE PNPSSKPKTAQQSKAGPQSQLCDKAASFIEELTSIFREAA----KPRNRSPNGESSSPDS PALLD_RAT PALLD_RAT ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RHD8_DANRE Q5RHD8_DANRE GYLSPKSHRLAMQQAQPPSS------------SSSSSEPQQEGVLQGQADVGSGE--LQG MYPN_HUMAN MYPN_HUMAN KVMQENSSSFSDLSERRERSSVPIPIPADTRDNEVNHALEQQEAKRREAEQAASE--AAG MYPN_MOUSE MYPN_MOUSE KVLQENSPTFSDLTERRERASVPIPIPADSRDNELNHAIEQREAKRREAELAAGE--AAA B1H3I5_XENTR B1H3I5_XENTR ------------------------------------------------------------ B2RTX2_HUMAN B2RTX2_HUMAN GYLSPKNQPSALLSASASQS----PME---DQGEMEREVKSPGARHCYQDNQDLA--VPH B7ZMM5_HUMAN B7ZMM5_HUMAN GYLSPKNQPSALLSASASQS----PME---DQGEMEREVKSPGARHCYQDNQDLA--VPH PALLD_HUMAN PALLD_HUMAN GYLSPKNQPSALLSASASQS----PME---DQGEMEREVKSPGARHCYQDNQDLA--VPH PALLD_MOUSE PALLD_MOUSE GYLSPKNQPSALMSASASQS----PTADQLDQLEMDAEVKQAQGSLCYQAHQASEETLPL PALLD_RAT PALLD_RAT ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RHD8_DANRE Q5RHD8_DANRE GGVSLDGPV------A----PPRFTQKLKSQEVAEGSPIRLECRVTGNPLPLVRWFCEGR MYPN_HUMAN MYPN_HUMAN GDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGK MYPN_MOUSE MYPN_MOUSE GDSTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGSRVQLDCIVVGIPPPQVRWYCEGK B1H3I5_XENTR B1H3I5_XENTR ------------------------------------------------------------ B2RTX2_HUMAN B2RTX2_HUMAN NRKSHPQPHSALHFPA----APRFIQKLRSQEVAEGSRVYLECRVTGNPTPRVRWFCEGK B7ZMM5_HUMAN B7ZMM5_HUMAN NRKSHPQPHSALHFPA----APRFIQKLRSQEVAEGSRVYLECRVTGNPTPRVRWFCEGK PALLD_HUMAN PALLD_HUMAN NRKSHPQPHSALHFPA----APRFIQKLRSQEVAEGSRVYLECRVTGNPTPRVRWFCEGK PALLD_MOUSE PALLD_MOUSE AHIPHPQPQKARHLPT----APRFIQKLRSQEVAEGSRVYLECRVTGNPTPRVRWFCEGK PALLD_RAT PALLD_RAT ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RHD8_DANRE Q5RHD8_DANRE ELHHCPDIQI-CRDGDLHTLVITEAFEDDTGRYTCVASNALGADNTSAEVYIEGASSSDS MYPN_HUMAN MYPN_HUMAN ELENSPDIHI-VQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDS MYPN_MOUSE MYPN_MOUSE ELENSPDIHI-VQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDS B1H3I5_XENTR B1H3I5_XENTR -------------------------------HYNCYN----------------------- B2RTX2_HUMAN B2RTX2_HUMAN ELHNTPDIQIHCEGGDLHTLIIAEAFEDDTGRYTCLATNPSGSDTTSAEVFIEGASSTDS B7ZMM5_HUMAN B7ZMM5_HUMAN ELHNTPDIQIHCEGGDLHTLIIAEAFEDDTGRYTCLATNPSGSDTTSAEVFIEGASSTDS PALLD_HUMAN PALLD_HUMAN ELHNTPDIQIHCEGGDLHTLIIAEAFEDDTGRYTCLATNPSGSDTTSAEVFIEGASSTDS PALLD_MOUSE PALLD_MOUSE ELYNSPDVQIHCESGELHTLVIAEAFEDDTGRYTCLATNPSGSDSTSAEVFIEGASSTDS PALLD_RAT PALLD_RAT ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????Y?C?????????????????????????

Q5RHD8_DANRE Q5RHD8_DANRE EGEGSVSKSRSGAMPQAQKKTSSVSLTIHTSSPKSPEAQPHRSTLVQPISTTPQRVQSPV MYPN_HUMAN MYPN_HUMAN EGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQ------HLVAQPRVATIQQCQSPT MYPN_MOUSE MYPN_MOUSE EGDPNKEEMNRIQKPNEVSSPPTTSAAIPPAAEAQPLA-------AQPRVSTVQQCQSPT B1H3I5_XENTR B1H3I5_XENTR ------------------------------------------------------------ B2RTX2_HUMAN B2RTX2_HUMAN DSESLAFKSRAGAMPQAQKKTTSVSLTIGSSSPKTGVT----TAVIQPLSVPVQQVHSPT B7ZMM5_HUMAN B7ZMM5_HUMAN DSESLAFKSRAGAMPQAQKKTTSVSLTIGSSSPKTGVT----TAVIQPLSVPVQQVHSPT PALLD_HUMAN PALLD_HUMAN DSESLAFKSRAGAMPQAQKKTTSVSLTIGSSSPKTGVT----TAVIQPLSVPVQQVHSPT PALLD_MOUSE PALLD_MOUSE DSESLSFISKAGAMPQAQKKTTSVSLTIGSSAPKTGVT----TAVIQPLSVPVQQAHSAT PALLD_RAT PALLD_RAT ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RHD8_DANRE Q5RHD8_DANRE SSLY--AGDALAKAPPSFTKVLQDAQPSEGQVVVLECRVRGSLPLRVQWFREGQEIQDSP MYPN_HUMAN MYPN_HUMAN NYLQGLDGKPII-AAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSP MYPN_MOUSE MYPN_MOUSE NYLQGLNGKPII-AAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSP B1H3I5_XENTR B1H3I5_XENTR --------------------------------------------LKAVWEKVG--LQHSS B2RTX2_HUMAN B2RTX2_HUMAN SYLCRPDGTTTAYFPPVFTKELQNTAVAEGQVVVLECRVRGAPPLQVQWFRQGSEIQDSP B7ZMM5_HUMAN B7ZMM5_HUMAN SYLCRPDGTTTAYFPPVFTKELQNTAVAEGQVVVLECRVRGAPPLQVQWFRQGSEIQDSP PALLD_HUMAN PALLD_HUMAN SYLCRPDGTTTAYFPPVFTKELQNTAVAEGQVVVLECRVRGAPPLQVQWFRQGSEIQDSP PALLD_MOUSE PALLD_MOUSE SYLCRPDGTTMGCLLPVFTKELQNTAASEGQVVVLECRVRGAPPLQVQWFRQGSEIQDSP PALLD_RAT PALLD_RAT ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????W???G?????S?

Q5RHD8_DANRE Q5RHD8_DANRE DFRILQKKPRSAAEPEEICTLVIAEAFPEDGGLFCCTATNEYGSVNSTAQLTVTPVAEEM MYPN_HUMAN MYPN_HUMAN DFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLS MYPN_MOUSE MYPN_MOUSE DFRILQKKPRSMAEPEEICTLVIAEVFSEDSGCFTCTASNKYGTVSSIAQLDVRGNEDIS B1H3I5_XENTR B1H3I5_XENTR RWRV----------TEEICTLVIAETFPEDAGIFTCTARNDYGSVSCSAQLTVL-SANNT B2RTX2_HUMAN B2RTX2_HUMAN DFRILQKKPRSTAEPEEICTLVIAETFPEDAGIFTCSARNDYGSATSTAQLVVT-SANTE B7ZMM5_HUMAN B7ZMM5_HUMAN DFRILQKKPRSTAEPEEICTLVIAETFPEDAGIFTCSARNDYGSATSTAQLVVT-SANTE PALLD_HUMAN PALLD_HUMAN DFRILQKKPRSTAEPEEICTLVIAETFPEDAGIFTCSARNDYGSATSTAQLVVT-SANTE PALLD_MOUSE PALLD_MOUSE DFRILQKKPRSTAEPEEICTLVIAESFPEDAGIFTCSATNDYGSVTSTAQLVIT-SANNE PALLD_RAT PALLD_RAT --------------PEEICTLVIAESFPEDAGIFTCSARNDYGSVTSTAQLVVT-SANTE MATCH .********** *.**.* * *:* *.**:... *** : : CONSENSUS ??R???????????PEEICTLVIAE?F?ED?G?FTC?A?N?YG???S?AQL?V???????

Q5RHD8_DANRE Q5RHD8_DANRE PTNGVSGDESVFEDNQSFPPPPPPLPPPPPPIEISLLEVPPKTPPSAEAFQINELDI-WP MYPN_HUMAN MYPN_HUMAN NNGSLHSANSTTNLAAIEPQPSPPHSEPPS------VEQPPKPK--LEGVLVNHNEPRSS MYPN_MOUSE MYPN_MOUSE DNGALHSANSTTNPAVAEHQPSPLNPQPLS------EEQPPKPK--LEGVLVNHNEPRSS B1H3I5_XENTR B1H3I5_XENTR HTRNNVSSEEISGYDSQKPSPLSAVPNSSC------LEMSSKKN--SECFQTSQTDS-EA B2RTX2_HUMAN B2RTX2_HUMAN NCSYESMGESNNDHFQHFPPP-PPILETSS------LELASKKP--SEIQQVNNPEL-GL B7ZMM5_HUMAN B7ZMM5_HUMAN NCSYESMGESNNDHFQHFPPP-PPILETSS------LELASKKP--SEIQQVNNPEL-GL PALLD_HUMAN PALLD_HUMAN NCSYESMGESNNDHFQHFPPP-PPILETSS------LELASKKP--SEIQQVNNPEL-GL PALLD_MOUSE PALLD_MOUSE NCSYDSTGEPNSDHFQHFPPP-PPILETGS------YELASQKP--SEIQQVNSPNL-GF PALLD_RAT PALLD_RAT NCSYDSMGEPNSDHFQHFPPP-PPILETGS------YELASQKP--SEIQQVNTPNL-GF MATCH : * . . * ..: * . : CONSENSUS ??????????????????P?P?P??????????????E?????????E????N???????

Q5RHD8_DANRE Q5RHD8_DANRE SVTALPVQVSTDKKP-EESRPNKP---LQNGQFTKPLDESLS---------SPSS-VKET MYPN_HUMAN MYPN_HUMAN SRIGLRVHFNLPEDD-KGSEASSE-AGVVTTRQTRP--DSFQERFNGQATKTPEP-SSPV MYPN_MOUSE MYPN_MOUSE SRIGLRVHFNLPEDD-KDMEASSG-SGAANTSQTRP--NSFPERFNGQEARIPEP-SSPI B1H3I5_XENTR B1H3I5_XENTR NMEKSHFQFYPVENNSNGLHANNGVNGDSNNVDSKY--ISVT---------SPCT-FSPV B2RTX2_HUMAN B2RTX2_HUMAN SRAALQMQFNAAERETNGVHPSRGVNGLINGKANSN--KSLP---------TPAVLLSPT B7ZMM5_HUMAN B7ZMM5_HUMAN SRAALQMQFNAAERETNGVHPSRGVNGLINGKANSN--KSLP---------TPAVLLSPT PALLD_HUMAN PALLD_HUMAN SRAALQMQFNAAERETSGVHPSRGVNGLINGKANSN--KSLP---------TPAVLLSPT PALLD_MOUSE PALLD_MOUSE SMAALQMQFNTAERETNGVHPSHGVNGLINGKAYGN--KSPP---------TPTALLSPT PALLD_RAT PALLD_RAT NMAALQMQFNSAERETNGVHPSHGVNGLINGKAYGN--KSPP---------TPAALLSPT MATCH . .:. : . ... . * * . CONSENSUS ????L???F???E?????????????G??N?????????S????????????P????SP?

Q5RHD8_DANRE Q5RHD8_DANRE AAPPPSPSAVRA------------------------------------------------ MYPN_HUMAN MYPN_HUMAN KEPPPVLAKPKLDSTQLQQLHNQVLLEQH--------QLQ---------NPPPSSPKEFP MYPN_MOUSE MYPN_MOUSE KEPPPVLAKPKLDSTQLQQLHNQVLLEQQ--------QLQ---------NTSPSSPKE-S B1H3I5_XENTR B1H3I5_XENTR KEPPPVPAKPKLDTQIIQQLQNQIRLEQEGAVWKQGSVQL---------NTPPSPSFPPP B2RTX2_HUMAN B2RTX2_HUMAN KEPPPLLAKPKL------------------------------------------------ B7ZMM5_HUMAN B7ZMM5_HUMAN KEPPPLLAKPKL------------------------------------------------ PALLD_HUMAN PALLD_HUMAN KEPPPLLAKPKLDPLKLQQLQNQIRLEQEAGARQPPPAPR---------SAPPSPPFPPP PALLD_MOUSE PALLD_MOUSE KEPPPLLAKPKLDPLKLQQLQNQVRLEQEACAWPPAPPGVPCNSSSSGSSAPPSPPFPPP PALLD_RAT PALLD_RAT KEPPPLLAKPKL------------------------------------------------ MATCH *** : : CONSENSUS KEPPP??AKPKL????????????????????????????????????????????????

Q5RHD8_DANRE Q5RHD8_DANRE ------------------------------------------------------------ MYPN_HUMAN MYPN_HUMAN FSM------TVLNSNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSP MYPN_MOUSE MYPN_MOUSE LHM------SALNS-APPAVTISSKQVKGPAPQMFNLARPKHFFPASSTSTATVSPSSSP B1H3I5_XENTR B1H3I5_XENTR PSFQELEASQLITSPEQMNVLNSHNSPMQPAS-SFNYARPKQFIAAQNMSPTSGYISPSS B2RTX2_HUMAN B2RTX2_HUMAN ------------------------------------------------------------ B7ZMM5_HUMAN B7ZMM5_HUMAN ------------------------------------------------------------ PALLD_HUMAN PALLD_HUMAN PAFPELAACTPPASPEPMSALASRSAPAMQSSGSFNYARPKQFIAAQNLGPASGHGTPAS PALLD_MOUSE PALLD_MOUSE PPAFPELAACASPVPSEPMSALASRATAMQSSGSFNYARPKQFIAAQNLGPASGLPTPTS PALLD_RAT PALLD_RAT ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RHD8_DANRE Q5RHD8_DANRE ----------------------------------------------PPLPTKPKPKL--- MYPN_HUMAN MYPN_HUMAN VFTLSSTPQTIQRTVSKESL----LVSHPSVQTKSPGGLSIQNEPLPPGPTEPTPPPF-T MYPN_MOUSE MYPN_MOUSE VFTLSNTPQTIQRTVSKESL----LMAHPSTQGRSPGGLSIQNEPAPPSPAEPAAPPTAA B1H3I5_XENTR B1H3I5_XENTR GSSTSSLPSPMSPSTPQKQFGRAPVPPFSQPFPQEGEQFWSPASSSPPPPPPPVLSPTAN B2RTX2_HUMAN B2RTX2_HUMAN ------------------------------------------------------------ B7ZMM5_HUMAN B7ZMM5_HUMAN ------------------------------------------------------------ PALLD_HUMAN PALLD_HUMAN SPSSSSLPSPMSPT--PRQFGRAPVPPFAQPFGAEPEAPWGSSSPSPPPPPPPVFSPTAA PALLD_MOUSE PALLD_MOUSE SPSSSSLPSPLSPT--PRPFGRAPGPPFV-----EPEAMWGPSSPSPPPPPPPVFSPSAA PALLD_RAT PALLD_RAT ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RHD8_DANRE Q5RHD8_DANRE ------------------------------------------------------------ MYPN_HUMAN MYPN_HUMAN FSIPSGNQFQPRCVSPIPVS----------P-----TSRIQNPVAFLSSVLPSLPAIPPT MYPN_MOUSE MYPN_MOUSE YSIPSGNQFQPHCVSPTPVS----------P-----TGRIQNPVAFLSSVLPSLPSIPPT B1H3I5_XENTR B1H3I5_XENTR YSVVDAFPLPPPPPPPLPVSVLSPSYSPSPSPTGRAPNSSQSPAAFISSMLPTQSSPITF B2RTX2_HUMAN B2RTX2_HUMAN ------------------------------------------------------------ B7ZMM5_HUMAN B7ZMM5_HUMAN ------------------------------------------------------------ PALLD_HUMAN PALLD_HUMAN FPVPDVFPLPPPPPPLPSPGQASHCSSPATR-----FGHSQTPAAFLSALLPSQPPPAAV PALLD_MOUSE PALLD_MOUSE YPVPDVFPLPPPPPPLPSSTSHCASPA---R-----FGPSQTPAAFLSALLPSQPPPVAV PALLD_RAT PALLD_RAT ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q5RHD8_DANRE Q5RHD8_DANRE ---------------ALPRKTTPRTPRIISDSDIQGSKDAVIQDLERKLRFKEERLSNGQ MYPN_HUMAN MYPN_HUMAN NAMGLPRSAPSMPSQGLAKKNT-KSPQPVNDDNIRETKNAVIRDLGKKITF-SDVRPNQQ MYPN_MOUSE MYPN_MOUSE NAMGLPKSAPSVPSQGLMKKTT-KAPQAVSDDYIRETKNSVILDLGKKVNF-GDVRSHQQ B1H3I5_XENTR B1H3I5_XENTR NELGLPK---GVMPPGFPKKSS-RTARIASDEEIQGTKDAVIQDLERKLRFKEELLNNGQ B2RTX2_HUMAN B2RTX2_HUMAN ---------------GFPKKAS-RTARIASDEEIQGTKDAVIQDLERKLRFKEDLLNNGQ B7ZMM5_HUMAN B7ZMM5_HUMAN ---------------GFPKKAS-RTARIASDEEIQGTKDAVIQDLERKLRFKEDLLNNGQ PALLD_HUMAN PALLD_HUMAN NALGLPK---GVTPAGFPKKAS-RTARIASDEEIQGTKDAVIQDLERKLRFKEDLLNNGQ PALLD_MOUSE PALLD_MOUSE NALGLPK---GVTPAGFPKKSS-RTARIASDEEIQGTKDAVIQDLERKLRFKEDLLNNGQ PALLD_RAT PALLD_RAT ---------------GFPKKAS-RTARIASDEEIQGTKDAVIQDLERKLRFKEDLLNNGQ MATCH .: :* : ::.: .*. *: :*::** ** :*: * : : * CONSENSUS ???????????????G??KK?????????SD??I??TK?AVI?DL??K??F??????N?Q

Q5RHD8_DANRE Q5RHD8_DANRE QRLTYEEKMARRLLGADNAATVFNTQQVEEEANTQ------------------------- MYPN_HUMAN MYPN_HUMAN ----------------------------------------------------EYKISSFE MYPN_MOUSE MYPN_MOUSE ----------------------------------------------------EYKISSFE B1H3I5_XENTR B1H3I5_XENTR PKLTYEEKMARRLLGADSAATVFNIQEPEEDGNAQ-----------------EYKVSSFE B2RTX2_HUMAN B2RTX2_HUMAN PRLTYEERMARRLLGADS-ATVFNIQEPEEETANQ-----------------EYKVSSCE B7ZMM5_HUMAN B7ZMM5_HUMAN PRLTYEERMARRLLGADS-ATVFNIQEPEEETANQDIGSPHASVGSPLDGQKEYKVSSCE PALLD_HUMAN PALLD_HUMAN PRLTYEERMARRLLGADS-ATVFNIQEPEEETANQ-----------------EYKVSSCE PALLD_MOUSE PALLD_MOUSE PRLTYEERMARRLLGADS-ANVFNIQEPEETAANQDAGAPRASVGGPLDGQKEYKVSSCE PALLD_RAT PALLD_RAT PRLTYEERMARRLLGADS-ANVFNIQEPEETAANQ-----------------EYKVSSCE MATCH CONSENSUS ????????????????????????????????????????????????????EYK?SS?E

Q5RHD8_DANRE Q5RHD8_DANRE ------------------------------------------------------------ MYPN_HUMAN MYPN_HUMAN QRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIV MYPN_MOUSE MYPN_MOUSE QRLMNEIEFRLERTPVDESDDEIEHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIV B1H3I5_XENTR B1H3I5_XENTR QRLISEIEYRLERSPVEESDEEVEHGDEPVDNGEAPQFETKLKHYKIFEGMSSTFTCKVT B2RTX2_HUMAN B2RTX2_HUMAN QRLISEIEYRLERSPVDESGDEVQYGDVPVENGMAPFFEMKLKHYKIFEGMPVTFTCRVA B7ZMM5_HUMAN B7ZMM5_HUMAN QRLISEIEYRLERSPVDESGDEVQYGDVPVENGMAPFFEMKLKHYKIFEGMPVTFTCRVA PALLD_HUMAN PALLD_HUMAN QRLISEIEYRLERSPVDESGDEVQYGDVPVENGMAPFFEMKLKHYKIFEGMPVTFTCRVA PALLD_MOUSE PALLD_MOUSE QRLISEIEYRLERSPVDESGDEVQDPDVPVENATAPFFEMKLKHYKIFEGMPVTFTCRVA PALLD_RAT PALLD_RAT QRLISEIEYRLERSPVEESGDEVQEAEVPVENAAAPFFEMKLKHYKIFEGMPVTFTCRVA MATCH CONSENSUS QRL??EIE?RLER?PV?ES??E??????P?????AP?F???LKH????EG???TFTC???

Q5RHD8_DANRE Q5RHD8_DANRE ------------------------------------------------------------ MYPN_HUMAN MYPN_HUMAN GIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRIS MYPN_MOUSE MYPN_MOUSE GIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTHGDDDGNYTIMAANPQGRIS B1H3I5_XENTR B1H3I5_XENTR GNPKPKIYWFKDGKQISKRSEHYRIQREPDGTCSLHTSASSLDDDGNYTIMAANPQGRIS B2RTX2_HUMAN B2RTX2_HUMAN GNPKPKIYWFKDGKQISPKSDHYTIQRDLDGTCSLHTTASTLDDDGNYTIMAANPQGRIS B7ZMM5_HUMAN B7ZMM5_HUMAN GNPKPKIYWFKDGKQISPKSDHYTIQRDLDGTCSLHTTASTLDDDGNYTIMAANPQGRIS PALLD_HUMAN PALLD_HUMAN GNPKPKIYWFKDGKQISPKSDHYTIQRDLDGTCSLHTTASTLDDDGNYTIMAANPQGRIS PALLD_MOUSE PALLD_MOUSE GNPKPKIYWFKDGKQISPKSDHYTIQRDLDGTCSLHTTASTLDDDGNYTIMAANPQGRVS PALLD_RAT PALLD_RAT GSPKPKIYWFKDGKQISPKSDHYTIQRDVDGTCSLHTTASTLDDDGNYTIMAANTQGRVS MATCH CONSENSUS G?P?PK?YWFKDGKQIS????H????R??DGTCSLH??????DDDGNYTIMAAN?QGR?S

Q5RHD8_DANRE Q5RHD8_DANRE ------------------------------------------------------------ MYPN_HUMAN MYPN_HUMAN CSGHLMVQSLPIRSRL--TSAGQSHRGRSRVQERD----KEPLQERFFRPHFLQAPGDMV MYPN_MOUSE MYPN_MOUSE CSGHLMVQGLPIRSRL--SPA-LSHRGRSRMQERD----KEPLQERFFRPHFLQAPGDMV B1H3I5_XENTR B1H3I5_XENTR CTGRLMVQAVNQRGRTARTPTSQLHVRRPRSRSRDSGDENEPIQERFFRPHFLQAPGDLI B2RTX2_HUMAN B2RTX2_HUMAN CTGRLMVQAVNQRGRSPRSPSGHPHVRRPRSRSRDSGDENEPIQERFFRPHFLQAPGDLT B7ZMM5_HUMAN B7ZMM5_HUMAN CTGRLMVQAVNQRGRSPRSPSGHPHVRRPRSRSRDSGDENEPIQERFFRPHFLQAPGDLT PALLD_HUMAN PALLD_HUMAN CTGRLMVQAVNQRGRSPRSPSGHPHVRRPRSRSRDSGDENEPIQERFFRPHFLQAPGDLT PALLD_MOUSE PALLD_MOUSE CTGRLMVQAVNQRGRSPRSPSGHPHARRPRSRSRDSGDENEPIQERFFRPHFLQAPGDLT PALLD_RAT PALLD_RAT CTGRLMVQAVNQRGRSPRSPPGHPHARRPRSRSRDSGDENEPIQERFFRPHFLQAPGDLT MATCH CONSENSUS C?G?LMVQ????R?R?????????H??R?R???RD?????EP?QERFFRPHFLQAPGD??

Q5RHD8_DANRE Q5RHD8_DANRE ------------------------------------------------------------ MYPN_HUMAN MYPN_HUMAN AHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGT MYPN_MOUSE MYPN_MOUSE AHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGT B1H3I5_XENTR B1H3I5_XENTR VQEGKLCRMDCKVSGLPTPDLSWQLNGRPVRPDNSHKMLVRENGVHSLVIEPVTTRDAGI B2RTX2_HUMAN B2RTX2_HUMAN VQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKMLVRENGVHSLIIEPVTSRDAGI B7ZMM5_HUMAN B7ZMM5_HUMAN VQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKMLVRENGVHSLIIEPVTSRDAGI PALLD_HUMAN PALLD_HUMAN VQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKMLVRENGVHSLIIEPVTSRDAGI PALLD_MOUSE PALLD_MOUSE VQEGKLCRMDCKVSGLPTPDLSWQLDGKPIRPDSAHKMLVRENGVHSLIIEPVTSRDAGI PALLD_RAT PALLD_RAT VQEGKLCRMDCKVSGLPTPDLSWQLDGKPIRPDSAHKMLVRENGVHSLIIEPVTSRDAGI MATCH CONSENSUS ??EG?LCR?DCKVSGLP?P?L?W?L?G?P??PD??HKMLVRE?GVHSL?I?P?T?RDAG?

Q5RHD8_DANRE Q5RHD8_DANRE ------------------------------------------------------------ MYPN_HUMAN MYPN_HUMAN YKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVF MYPN_MOUSE MYPN_MOUSE YTCVATNKTGQNSFSLELTVVAKEVKKAPVILEKLQNSGVPEGHPVRLEGRVIGMPPPVF B1H3I5_XENTR B1H3I5_XENTR YTCVASNRAGQNSFTLELIVAAKDAHKPPVFIDKLQNTGVAEGYPVRLECRVSGMPPPQI B2RTX2_HUMAN B2RTX2_HUMAN YTCIATNRAGQNSFSLELVVAAKEAHKPPVFIEKLQNTGVADGYPVRLECRVLGVPPPQI B7ZMM5_HUMAN B7ZMM5_HUMAN YTCIATNRAGQNSFSLELVVAAKEAHKPPVFIEKLQNTGVADGYPVRLECRVLGVPPPQI PALLD_HUMAN PALLD_HUMAN YTCIATNRAGQNSFSLELVVAAKEAHKPPVFIEKLQNTGVADGYPVRLECRVLGVPPPQI PALLD_MOUSE PALLD_MOUSE YTCIATNRAGQNSFNLELVVAAKEAHKAPVFMEKLQNTGVADGYPVRLECRVSGVPPPQI PALLD_RAT PALLD_RAT YTCIATNRAGQNSFNLELVVAAKEAHKAPVFIEKLQNTGVADGYPVRLECRVSGVPPPQI MATCH CONSENSUS Y?C?A?N??GQNSF?LEL?V?AK???K?PV???KLQN?GV??G?PVRLE?RV?G?PPP??

Q5RHD8_DANRE Q5RHD8_DANRE ------------------------------------------------------------ MYPN_HUMAN MYPN_HUMAN YWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI MYPN_MOUSE MYPN_MOUSE YWKKDNETIPFTRERISMHQDTTGYVCLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI B1H3I5_XENTR B1H3I5_XENTR FWKKENESLTYSTERVSMHQDNYGYLCLLIQGATKEDAGWYTVSAKNEAGIVSCTARLDV B2RTX2_HUMAN B2RTX2_HUMAN FWKKENESLTHSTDRVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEAGIVSCTARLDV B7ZMM5_HUMAN B7ZMM5_HUMAN FWKKENESLTHSTDRVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEAGIVSCTARLDV PALLD_HUMAN PALLD_HUMAN FWKKENESLTHSTDRVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEAGIVSCTARLDV PALLD_MOUSE PALLD_MOUSE FWKKENESLTHSTERVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEAGIVSCTARLDV PALLD_RAT PALLD_RAT FWKKENESLTHSTDRVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEAGIVSCTARLDV MATCH CONSENSUS ?WKK?NE???????R?SMHQD??GY?CLLIQ?A?K?DAGWYT?SAKNEAGIVSCTARLD?

Q5RHD8_DANRE Q5RHD8_DANRE ----------------------------------------------------------- MYPN_HUMAN MYPN_HUMAN YAQWHHQ--IPPPMSVRPSGSRYGSLTSKGLDIFSAFSSMESTMVYSCSSRSVVESDEL MYPN_MOUSE MYPN_MOUSE YAQWHQQ--IPTPISIRPSGSRYGSLTSKGLDIFSAFSSVESTMLYSCTSRSVVESDEL B1H3I5_XENTR B1H3I5_XENTR HTQWHQQSLAPKTRKVRPSASRYAALSDQGLDIKAAFLP-EANPVH--LQPALVESEDL B2RTX2_HUMAN B2RTX2_HUMAN YISRH------------------------------------------------------ B7ZMM5_HUMAN B7ZMM5_HUMAN YISRH------------------------------------------------------ PALLD_HUMAN PALLD_HUMAN YTQWHQQSQSTKPKKVRPSASRYAALSDQGLDIKAAFQP-EANPSHLTLNTALVESEDL PALLD_MOUSE PALLD_MOUSE YTQWHQQPQTTKPKKVRPSASRYAALSDQGLDIKAAFQP-EASPSHLTLNSGLVESEDL PALLD_RAT PALLD_RAT Y---------------------------------------------------------- MATCH CONSENSUS ???????????????????????????????????????????????????????????


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