Alignment of the gene Family HBG059646 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
EFHC2_MOUSE EFHC2_MOUSE -----MALPFLPGNSFNRNIGKERFHKSQHWGFCNNVRMLVSENKPGVGGDLLYGQKIKP Q059K2_MOUSE Q059K2_MOUSE -----MALPFLPGNSFNRNIGKERFHKSQHWGFCNNVRMLVSENKPGVGGDLLYGQKIKP B1AL25_HUMAN B1AL25_HUMAN -NNTAGRRRCLPGPLF-WDPGFSDTERH--------------------GPASAAGQQLQP A8KAA2_HUMAN A8KAA2_HUMAN -----MALPLLPGNSFNRNVGKEKFHKSQHWGFCNSVMMLVSDEKPGIGGEPLLGQKIKP A8K572_HUMAN A8K572_HUMAN -----MALPLLPGNSFNRNVGKEKFHKSQHWGFCNNVMMLVSDEKPGIGGEPLLGQKIKP EFHC2_HUMAN EFHC2_HUMAN -----MALPLLPGNSFNRNVGKEKFHKSQHWGFCNNVMMLVSDEKPGIGGEPLLGQKIKP Q32TF6_CIOIN Q32TF6_CIOIN -----MALPYLPGNSFNKSLGKEKFHKSHHFDYCNDVSMLVGEQKPGIGGELLLGQKKQP B8A5Q4_DANRE B8A5Q4_DANRE -----MALPMLPGNSVNRNLGKDKFHKSQHFDYSNGVAMMVGTEKPGIGGDLLLGQSARA EFHC2_DANRE EFHC2_DANRE -----MALPMLPGNSVNRNLGKDKFHKSQHFDYSNGVAMMVGTEKPGIGGDLLLGQSARA B5DEU8_XENTR B5DEU8_XENTR -----MALPFLPGNSFNRNLGKEKFHKSQHFGYSNDISMWLGEEKPGVGGAPLLGQNLKP EFHC2_CHICK EFHC2_CHICK -----MALPLLPGFSLGRNVGKEKFHKSQHWGYCNNVAMLLAEDKPGIGGEPLPGQKLIP Q7T2F1_DANRE Q7T2F1_DANRE SINTGHGLPFLPGNTF-RDLTKSAFHRAQTLDFKNGYAQPRRPVV-GIGQDPLLSVNISH Q32TF7_CIOIN Q32TF7_CIOIN ATTRAEGLPFLPGNTF-EDPTKSRFHVTNTLKFKNGYAQQHSPSV-GLGGERLTYNQLSE B2CKC6_MOUSE B2CKC6_MOUSE GTNPVHGLPFLPGSSF-TDSTKTAFHRSQTLNYRNGYAVVRRPTM-GIGGDRLHYNQLSQ EFHC1_MOUSE EFHC1_MOUSE GTNPVHGLPFLPGSSF-TDSTKTAFHRSQTLNYRNGYAVVRRPTM-GIGGDRLHYNQLSQ B7Z2S4_HUMAN B7Z2S4_HUMAN ----------------------------MSW----------------------------- Q4R667_MACFA Q4R667_MACFA ------------------------------------------------------------ B2CKC5_HUMAN B2CKC5_HUMAN VSNPVHGLPFLPGTSF-KDSTKTAFHRSQTLSYRNGYAIVRRPTV-GIGGDRLQFNQLSQ EFHC1_HUMAN EFHC1_HUMAN VSNPVHGLPFLPGTSF-KDSTKTAFHRSQTLSYRNGYAIVRRPTV-GIGGDRLQFNQLSQ B4DMU3_HUMAN B4DMU3_HUMAN -------------------MLKTAFHRSQTLSYRNGYAIVRRPTV-GIGGDRLQFNQLSQ Q32TG2_CHICK Q32TG2_CHICK SSEPKPGLPFLPGCSF-RDPMKTSFHRSQTLGYKNGFAFSRLPTV-GIGGERLYVNQPSQ Q66IK9_XENTR Q66IK9_XENTR ASYPVHGLPFLPGNTY-RDPTKSAFHRSQTLTYKNGYSRPILPTV-GIGREPITANQLSQ Q6DJD5_XENLA Q6DJD5_XENLA ASHPVQGLPFLPGNTY-RDPTKSAFHRSQTLTYRNGYSRPILPTV-GIGREPITVNQLSQ MATCH CONSENSUS ???????LP?LPG????????K??FH????????N???????????G?G???????????

EFHC2_MOUSE EFHC2_MOUSE --------KHSVFPKGDGTD------APSWVAFDKQVLSFDAYLEDEISDKRQEIFRIRY Q059K2_MOUSE Q059K2_MOUSE --------KHSVFPKGDGTD------APSWVAFDKQVLSFDAYLEDEISDKRQEIFRIRY B1AL25_HUMAN B1AL25_HUMAN -----------QREKGDGSD------VPSWVAFDKQVLSFDAYLEEEVLDKSQTNYRIRY A8KAA2_HUMAN A8KAA2_HUMAN --------KCSIYPKGDGSD------VPSWVAFDKQVLSFDAYLEEEVLDKSQTNYRIRY A8K572_HUMAN A8K572_HUMAN --------KCSIYPKGDGSD------VPSWVAFDKQVLSFDAYLEEEVLDKSQTNYRIRY EFHC2_HUMAN EFHC2_HUMAN --------KCSIYPKGDGSD------VPSWVAFDKQVLSFDAYLEEEVLDKSQTNYRIRY Q32TF6_CIOIN Q32TF6_CIOIN --------KHSVFPKGEGSN------APAWVAFDRQVLCFQAYFQEAVHEKREEQYRIRG B8A5Q4_DANRE B8A5Q4_DANRE --------KYSRFPKGEGSG------APAWLAFDKQVLCFDAYFNEDVPQRREEKYRVRK EFHC2_DANRE EFHC2_DANRE --------KYSRFPKGEGSG------APAWLAFDKQVLCFDAYFNEAVPQRREEKYRVRK B5DEU8_XENTR B5DEU8_XENTR --------KFSVFPKGVGSD------APSWVAFDKQVLSFDAYFEEEVHQRREETYRIRQ EFHC2_CHICK EFHC2_CHICK --------KSSVFPAELGCG------APAWLAFDKQVLSFDAYFEEEVPDKNQEPYRIRH Q7T2F1_DANRE Q7T2F1_DANRE SERNQLITDIPNLTYGTDRSHLPLEFIPAHAAYDKKVLRFYGYFRQEVLHSWDEHFRIRP Q32TF7_CIOIN Q32TF7_CIOIN SELDELANKMPTLTYGQAKQAPPETFVPAHLAFDKKVLKFTGYFKETVHESPQEFYRVRP B2CKC6_MOUSE B2CKC6_MOUSE AELDELANKAPILTYGPLKQAPLAEFVPAHVAFDKKVLKFSAYFQEDVPISMEEHYRIRH EFHC1_MOUSE EFHC1_MOUSE AELDELANKAPILTYGPLKQAPLAEFVPAHVAFDKKVLKFSAYFQEDVPISMEEHYRIRH B7Z2S4_HUMAN B7Z2S4_HUMAN -----------------------------------PVLKFDAYFQEDVPMSTEEQYRIRQ Q4R667_MACFA Q4R667_MACFA ------------------------------------------------------------ B2CKC5_HUMAN B2CKC5_HUMAN AELDELASKAPVLTYGQPKQAPPADFIPAHVAFDKKVLKFDAYFQEDVPMSTEEQYRIRQ EFHC1_HUMAN EFHC1_HUMAN AELDELASKAPVLTYGQPKQAPPADFIPAHVAFDKKVLKFDAYFQEDVPMSTEEQYRIRQ B4DMU3_HUMAN B4DMU3_HUMAN AELDELASKAPVLTYGQPKQAPPADFIPAHVAFDKKVLKFDAYFQEDVPMSTEEQYRIRQ Q32TG2_CHICK Q32TG2_CHICK AELDELSNTGPTLTYGQAKKAPPSGFIPAHVAFDKKVLKFDAYFQEDVPLSTEEHYRIRQ Q66IK9_XENTR Q66IK9_XENTR AELDELANKRPTLTYGRAKPAPPSDFIPSYVAFDKKVLRFEGYFQETVPLSPEEHYRVRR Q6DJD5_XENLA Q6DJD5_XENLA AELDELSNKRPTLTYGRAKPAPPSDFIPSYVAFDKKVLRFEGYFQETVPLSPDEHYRVRR MATCH CONSENSUS ???????????????G???????????P???AFDK?VL?F??Y??E?V???????YR?R?

EFHC2_MOUSE EFHC2_MOUSE YKIYFYLEDDTIQVNEPEVINSGLPQGTSIRRQRIPYPPPNDDQFYTVYDFNINISVVFY Q059K2_MOUSE Q059K2_MOUSE YKIYFYLEDDTIQVNEPEVINSGLPQGTSIRRQRIPYPPPNDDQFYTVYDFNINISVVFY B1AL25_HUMAN B1AL25_HUMAN YKIYFYPEDDTIQVNEPEVKNSGLLQGTSIRRHRITLPPPDEDQFYTVYHFNVGTEVVFY A8KAA2_HUMAN A8KAA2_HUMAN YKIYFYPEDDTIQVNEPEVKNSGLLQGTSIRRHRITLPPPDEDQFYTVYHFNVGTEVVFY A8K572_HUMAN A8K572_HUMAN YKIYFYPEDDTIQVNEPEVKNSGLLQGTSIRRHRITLPPPDEDQFYTVYHFNVGTEVVFY EFHC2_HUMAN EFHC2_HUMAN YKIYFYPEDDTIQVNEPEVKNSGLLQGTSIRRHRITLPPPDEDQFYTVYHFNVGTEVVFY Q32TF6_CIOIN Q32TF6_CIOIN CKIYFYLEDDSIQVIEPQVKNSGIPQGTLIRRHRVPLPAPRDDEYYTVEHFNVGNELILY B8A5Q4_DANRE B8A5Q4_DANRE CKIYFYLEDDTIQVVEPEFKNSGIPQGTLIRRHRIPLPAPKDDCFYNVHHFNINQEVVFY EFHC2_DANRE EFHC2_DANRE CKIYFYLEDDTIQVVEPEFKNSGIPQGTLIRRHRIPLPAPKDDCFYNVHHFNINQEVLFY B5DEU8_XENTR B5DEU8_XENTR CKIYFYLEDDTIQVVEPEIKNSGIPQGTIIRRHRIPLPAPNDDQFYTVDHLNLNKDIVFY EFHC2_CHICK EFHC2_CHICK CKIYFYLEDDTIQVLEPQVKNSGIIQGTIVRRHRIPLPSPNEDQFYTIDHFNINAEVIFY Q7T2F1_DANRE Q7T2F1_DANRE VVFYYHLEDDSICVTEPPVENSGIPQGKLIKRQR--LSKNPRGDLYHWKDLNVGMDINLF Q32TF7_CIOIN Q32TF7_CIOIN VEIFYYLEDDSISVVEPHVENSGMPQGKLIKRQR--LPKDDQGNHWHWKDLNLGMNVVFY B2CKC6_MOUSE B2CKC6_MOUSE VNIYYYLEDDSMSVIEPVVENSGIPQGKLIKRQR--FTKNDMGDHYHWKDLNRGINLTVY EFHC1_MOUSE EFHC1_MOUSE VNIYYYLEDDSMSVIEPVVENSGIPQGKLIKRQR--FTKNDMGDHYHWKDLNRGINLTVY B7Z2S4_HUMAN B7Z2S4_HUMAN VNIYYYLEDDSMSVIEPVVENSGILQGKLIKRQR--LAKNDRGDHYHWKDLNRGINITIY Q4R667_MACFA Q4R667_MACFA ------------------------------------------------------------ B2CKC5_HUMAN B2CKC5_HUMAN VNIYYYLEDDSMSVIEPVVENSGILQGKLIKRQR--LAKNDRGDHYHWKDLNRGINITIY EFHC1_HUMAN EFHC1_HUMAN VNIYYYLEDDSMSVIEPVVENSGILQGKLIKRQR--LAKNDRGDHYHWKDLNRGINITIY B4DMU3_HUMAN B4DMU3_HUMAN VNIYYYLEDDSMSVIEPVVEDSGILQGKLIKRQR--LAKNDRGDHYHWKDLNRGINITIY Q32TG2_CHICK Q32TG2_CHICK VGIYYYLEDDTISVTEPVVKNSGIRQGKLIRRHR--VPKNDHGDHYHWKDLNRGINITMY Q66IK9_XENTR Q66IK9_XENTR VTLYYYLEDDTISVIEPPMENSGIPQGTFIKRQR--HPKNANGDPYHWKDLNVGINVTLY Q6DJD5_XENLA Q6DJD5_XENLA ITLYYYLEDDTISVVEPAVENSGIPQGTFIKRQR--HPKNENGDPYHWKDLNVGINITLY MATCH CONSENSUS ??IY?Y?EDD???V?EP???NSG??QG??I?R?R???????????Y?????N???????Y

EFHC2_MOUSE EFHC2_MOUSE GRTFKIYDCDPFTKNFLKKIGIKLNPPGQCPLDPYMKMRRETLEFVDPFRPY---QSFDT Q059K2_MOUSE Q059K2_MOUSE GRTFKIYDCDPFTKNFLKKIGIKLNPPGQCPLDPYMKMRRETLEFVDPFRPY---QSFDT B1AL25_HUMAN B1AL25_HUMAN GRTFKIYDCDAFTRNFLRKIGVKVNPPVQCPEDPYMKIRREVVEHVEPLRPY---ESLDT A8KAA2_HUMAN A8KAA2_HUMAN GRTFKIYDCDAFTRNFLRKIGVKVNPPVQCPEDPYMKIRREVVEHVEPLRPY---ESLDT A8K572_HUMAN A8K572_HUMAN GRTFKIYDCDAFTRNFLRKIGVKVNPPVQCPEDPYMKIRREVVEHVEPLRPY---ESLDT EFHC2_HUMAN EFHC2_HUMAN GRTFKIYDCDAFTRNFLRKIGVKVNPPVQCPEDPYMKIRREVVEHVEPLRPY---ESLDT Q32TF6_CIOIN Q32TF6_CIOIN GRKFKLTDCDVFTKNFLRKLGVRVNTPDTVPKDPYSNLRNEMEESMQALRPY---ERTDT B8A5Q4_DANRE B8A5Q4_DANRE SRNFMITDCDPFTRNFLIKMGVRLNPPASTPADPYTTLRQELEENMKPLRPY---ERLDT EFHC2_DANRE EFHC2_DANRE SRNFMITDCDPFTRNFLVKMGVRLNPPASTPADPYTTLRQELEENMKPLRPY---ERLDT B5DEU8_XENTR B5DEU8_XENTR SKIYRIVNCDEFTRNFLRKLGVRINPPDSVPSDAYSSTRKK-MEEMQPLRPY---ERIDT EFHC2_CHICK EFHC2_CHICK ARRYKIIDCDQFTKHFLRKMGFKLNPPGNRPDDPYTKERQKILDSMNPLRPY---ERIDT Q7T2F1_DANRE Q7T2F1_DANRE GEVYRITHCDPFTQDFMESQGIVLNEFESIPSDPYTARRAH--NQQTHITPY---DHNHQ Q32TF7_CIOIN Q32TF7_CIOIN GKAFRITNCDQFTANFMESEGLILNQPESVPQDPYTESRKQ------PLRSYTTRSDFDK B2CKC6_MOUSE B2CKC6_MOUSE GKTFRIVDCDRFTQDFLESQGIELNPSEKIPLDPYTQLRKE------PVRKYVTPSDFDQ EFHC1_MOUSE EFHC1_MOUSE GKTFRIVDCDRFTQDFLESQGIELNPSEKIPLDPYTQLRKE------PVRKYVTPSDFDQ B7Z2S4_HUMAN B7Z2S4_HUMAN GKTFRVVDCDQFTQVFLESQGIELNPPEKMALDPYTELRKQ------PLRKYVTPSDFDR Q4R667_MACFA Q4R667_MACFA -----------------------------MALDPYTELRKQ------PLRKYVTPSDFDQ B2CKC5_HUMAN B2CKC5_HUMAN GKTFRVVDCDQFTQVFLESQGIELNPPEKMALDPYTELRKQ------PLRKYVTPSDFDQ EFHC1_HUMAN EFHC1_HUMAN GKTFRVVDCDQFTQVFLESQGIELNPPEKMALDPYTELRKQ------PLRKYVTPSDFDQ B4DMU3_HUMAN B4DMU3_HUMAN GKTFRVVDCDQFTQVFLESQGIELNPPEKMALDPYTELRKQ------PLRKYVTPSDFDQ Q32TG2_CHICK Q32TG2_CHICK GRTYRIVDCDPFTQVFLESRGIELNPPEKMVFDPYIELRQM------PMRMYITPSDFDQ Q66IK9_XENTR Q66IK9_XENTR GRTFRLISCDSFTQEFLESEGIELNPPEGIPTDPFTELRRR------PNRTFVTPSDFDK Q6DJD5_XENLA Q6DJD5_XENLA GRTFRVINCDTFTQEFLESEGIELNPPEGIPSDPYTELRRQ------PDRTFITPSDFDK MATCH *.: * : . . CONSENSUS ????????CD?FT??FL???G???NPP?????DPY???R????????P?R?Y??????D?

EFHC2_MOUSE EFHC2_MOUSE LKRFIQYDGKVLRFFCLWDDSTSLFGDRREFVLHYFLCDGTVEIREVLPSNSGRDAMSSF Q059K2_MOUSE Q059K2_MOUSE LKRFIQYDGKVLRFFCLWDDSTSLFGDRREFVLHYFLCDGTVEIREVLPSNSGRDAMSSF B1AL25_HUMAN B1AL25_HUMAN LKQFLQYHGKILCFFCLWDDSVSMFGDRRELILHYFLCDDTIEIKELLPHSSGRDALKMF A8KAA2_HUMAN A8KAA2_HUMAN LKQFLQYHGKILCFFCLWDDSVSMFGDRRELILHYFLCDDTIEIKELLPHSSGRDALKMF A8K572_HUMAN A8K572_HUMAN LKQFLQYHGKILCFFCLWDDSVSMFGDRRELILHYFLCDDTIEIKELLPHSSGRDALKMF EFHC2_HUMAN EFHC2_HUMAN LKQFLQYHGKILCFFCLWDDSVSMFGDRRELILHYFLCDDTIEIKELLPHSSGRDALKMF Q32TF6_CIOIN Q32TF6_CIOIN LKQFLDHDRHVLRFECYWDDADSMFGDTREMVLHYFLADDTIEIREVIPPNSGRDAVPVF B8A5Q4_DANRE B8A5Q4_DANRE LKQFLEHDRQVLRFYCYWDDSESMFGDPRELILHYFLADDTMEMYEVVPPNSGRDTVPKF EFHC2_DANRE EFHC2_DANRE LKQFLEHDRQVLRFYCYWDDSESMFGDPRELILHYFLADDTMEMYEVVPPNSGRDTVPKF B5DEU8_XENTR B5DEU8_XENTR LKQFLEHDRHVLRFFCFWDDT-TLFGDSRELVLYYYLADDTVEILEIIPANSGRDTTPVF EFHC2_CHICK EFHC2_CHICK LKQFLEHDGHVLRFYCVWDDPESLFHDPRELVLHYYLSDDTIDIKEVIPVNSGRDVVPLF Q7T2F1_DANRE Q7T2F1_DANRE LERFLALDRQVLRFFALWDDSDSLYGEKRPVTLHYYLVDDSVEICEHHEANSGRDPFPVL Q32TF7_CIOIN Q32TF7_CIOIN LKKFLELDRKVLRFYCVWDDRDSMFGEMRPYVLHYFLVDDTVEIREVHKPNDGHDPFPVL B2CKC6_MOUSE B2CKC6_MOUSE LKQFLTFDKQVLRFYAIWDDTDSLFGECRHYIIHYYLMDDTVEIREVHERNNGRDPFPLL EFHC1_MOUSE EFHC1_MOUSE LKQFLTFDKQVLRFYAIWDDTDSLFGECRHYIIHYYLMDDTVEIREVHERNNGRDPFPLL B7Z2S4_HUMAN B7Z2S4_HUMAN LKQFLTFDKQVLRFYAIWDDTDSMYGECRTYIIHYYLMDDTVEIREVHERNDGRDPFPLL Q4R667_MACFA Q4R667_MACFA LKQFLTFDKQVLRFYAIWDDTDSMYGECRTYIIHYYLMDDTVEIREVHERNDGRDPFPLL B2CKC5_HUMAN B2CKC5_HUMAN LKQFLTFDKQVLRFYAIWDDTDSMYGECRTYIIHYYLMDDTVEIREVHERNDGRDPFPLL EFHC1_HUMAN EFHC1_HUMAN LKQFLTFDKQVLRFYAIWDDTDSMYGECRTYIIHYYLMDDTVEIREVHERNDGRDPFPLL B4DMU3_HUMAN B4DMU3_HUMAN LKQFLTFDKQVLRFYAIWDDTDSMYGECRTYIIHYYLMDDTVEIREVHERNDGRDPFPLL Q32TG2_CHICK Q32TG2_CHICK LKQFLTYDKQVLRFYAMWDDTNSMFGENRPYIIHYYLADDTVEVREVHKPNDGRDPFPVF Q66IK9_XENTR Q66IK9_XENTR LKQYLTMDRKVLRFFAVWDDTESMFGEKHPVLIHYYLSDDTVEIREVHERNDGRDPFPVL Q6DJD5_XENLA Q6DJD5_XENLA LKQFITMDRKVLRFFAVWDDTDNMFGEKHPVLIHYYLSDDTLEIREVHERNDGRDPFPVL MATCH *:::: . ::* * . *** .:: : : ::*:* *.:::: * ..*:* : CONSENSUS LKQFL??D??VLRF???WDD??S??G??R????HY?L?DDT?EI?E????N?GRD?????

EFHC2_MOUSE EFHC2_MOUSE LRRGKLPKYGPPGIYQPGQITDRAVLNVYGGLSEWRADGYLLDKYQLGKVEQDFYTDQDL Q059K2_MOUSE Q059K2_MOUSE LRRGKLPKYGPPGIYQPGQITDRAVLNVYGGLSEWRADGYLLDKYQLGKVEQDFYTDQDL B1AL25_HUMAN B1AL25_HUMAN LRRSKLPKNCPPRVYQPGQITDRAVLNSYGDFIKNQADGYLFDRYKLGKVDQEFYKDSDL A8KAA2_HUMAN A8KAA2_HUMAN LRRSKLPKNCPPRVYQPGQITDRAVLNSYGDFIKNQADGYLFDRYKLGKVDQEFYKDSDL A8K572_HUMAN A8K572_HUMAN LRRSKLPKNCPPRVYQPGQITDRAVLNSYGDFIKNQADGYLFDRYKLGKVDQEFYKDSDL EFHC2_HUMAN EFHC2_HUMAN LRRSKLPKNCPPRVYQPGQITDRAVLNSYGDFIKNQADGYLFDRYKLGKVDQEFYKDSDL Q32TF6_CIOIN Q32TF6_CIOIN LKRARLPKSAPLPLRQPGEKTDRTVLNVFGPMGH--GGRYILDSLKTGAVYEDFYTSADL B8A5Q4_DANRE B8A5Q4_DANRE LHRGKLPKHAPIPKRQPGEITDRTVLNVFGPVGQ--GGRYILDSLKTGALEEEFYKDSDL EFHC2_DANRE EFHC2_DANRE LHRGKLPKHAPIPKRQPGEITDRTVLNVFGPVGQ--GGPYILDSLKTGALEEEFYKDSDL B5DEU8_XENTR B5DEU8_XENTR LHRGKLPKSSPQNVPQPGQVTARTVLNVFGPMGH--GGRYILDNLKTGAVHEEFYKDSDL EFHC2_CHICK EFHC2_CHICK LRRDKLPKYAPTGLYQPGTITSRTVLNVFGNLVGNRGR-YILDNRKTGAVHQEFYRDSDL Q7T2F1_DANRE Q7T2F1_DANRE LRRQKIPKH----IKPTCEPFPSCVLEVSPHDVK------------------EYFCPQDF Q32TF7_CIOIN Q32TF7_CIOIN LRRQRLPKN----RNDVHSSFPMIVMELTDHEVK------------------QWFTPQDF B2CKC6_MOUSE B2CKC6_MOUSE MNRQRMPKV----LVENAKNFPKCVLEISDQEVL------------------EWYTAKDF EFHC1_MOUSE EFHC1_MOUSE MNRQRMPKV----LVENAKNFPKCVLEISDQEVL------------------EWYTAKDF B7Z2S4_HUMAN B7Z2S4_HUMAN MNRQRVPKV----LVENAKNFPQCVLEISDQEVL------------------EWYTAKDF Q4R667_MACFA Q4R667_MACFA MNRQRMPKV----LVENAKNFPQCVLEISDQEVL------------------EWYTAKDF B2CKC5_HUMAN B2CKC5_HUMAN MNRQRVPKV----LVENAKNFPQCVLEISDQEVL------------------EWYTAKDF EFHC1_HUMAN EFHC1_HUMAN MNRQRVPKV----LVENAKNFPQCVLEISDQEVL------------------EWYTAKDF B4DMU3_HUMAN B4DMU3_HUMAN MNRQRVPKV----LVENAKNFPQCVLEISDQEVL------------------EWYTAKDF Q32TG2_CHICK Q32TG2_CHICK IKRQRLPKT----FVDKKKTFPSCVLEISDQEVL------------------EWYTAKDF Q66IK9_XENTR Q66IK9_XENTR MKRQHLPKV----VNDTKDTFPMCVLEISDQEVK------------------EWFSPGDF Q6DJD5_XENLA Q6DJD5_XENLA MKRQHLPKV----VNNTKETFPVSVLEISDQEVK------------------EWFSPKDF MATCH :.* ::** *:: ::: *: CONSENSUS ??R???PK????????????????VL??????????????????????????E?Y???D?

EFHC2_MOUSE EFHC2_MOUSE SIGATINVWGRKVLLCDCDEFTKTYYRTKYGVDN-FTPISCKPPH-L---PKIERKYPPY Q059K2_MOUSE Q059K2_MOUSE SIGATINVWGRKVLLCDCDEFTKTYYRTKYGVDN-FTPISCKPPH-L---PKIERKYPPY B1AL25_HUMAN B1AL25_HUMAN SLGVTINVWGRKVLLYDCDEFTKSYYKSKYGIEN-FTSVSCKPPSPP---PKIERKFPPY A8KAA2_HUMAN A8KAA2_HUMAN SLGVTINVWGRKVLLYDCDEFTKSYYKSKYGIEN-FTSVSCKPPSPP---PKIERKFPPY A8K572_HUMAN A8K572_HUMAN SLGVTINVWGRRVLLYDCDEFTKSYYKSKYGIEN-FTSVSCKPPSPP---PKIERKFPPY EFHC2_HUMAN EFHC2_HUMAN SLGVTINVWGRKVLLYDCDEFTKSYYKSKYGIEN-FTSVSCKPPSPP---PKIERKFPPY Q32TF6_CIOIN Q32TF6_CIOIN VIGAVVNVWGRKLVLCGCDNFTKEYYKTKFGLNDSFTPIKYKSDP-V---MKVPRPMPPY B8A5Q4_DANRE B8A5Q4_DANRE TIGAVINVWGRRVLICDCDYFTKEYYRSKYGIED-FPSISYKASP-P---PKPAKQVPPY EFHC2_DANRE EFHC2_DANRE TIGAVINVWGRRVLICDCDYFTKEYYRSKYGIED-FPSISYKASP-P---PKPAKQVPPY B5DEU8_XENTR B5DEU8_XENTR TIGAALNVWGRKVILCDCDEFTKNYYKTKFGIED-FTPVQYKAPQ-P---PRPKKEFPPY EFHC2_CHICK EFHC2_CHICK KIGAVINVWGRQIMLCDCDEFTKDYYRTKYGIED-FTPVPYKAPP-P---PKAEKPIPPY Q7T2F1_DANRE Q7T2F1_DANRE RVGEEVNLMGRRFLLYDCDDFTHKYYQHHHPDIP-IKPFTVDTRT-Q---QDIKRVIPPY Q32TF7_CIOIN Q32TF7_CIOIN ELGKTIFINGRRLLIYDCDDFTKNYYRVMTGQQT-FQPIPVTGMA-N---DLPKMELPPY B2CKC6_MOUSE B2CKC6_MOUSE IVGKPLTILGRTFFIYDCDPFTRQFYKDKFGMPD-LPPVDVTKKE-P---PPVKQELPPY EFHC1_MOUSE EFHC1_MOUSE IVGKPLTILGRTFFIYDCDPFTRQFYKDKFGMPD-LPPVDVTKKE-P---PPVKQELPPY B7Z2S4_HUMAN B7Z2S4_HUMAN IVGKSLTILGRTFFIYDCDPFTRRYYKEKFGITD-LPRIDVSKRE-P---PPVKQELPPY Q4R667_MACFA Q4R667_MACFA IVGKSLTVLGRTFFIYDCDPFTRRYYKEKFGITD-LPRIDVNKQE-P---PPVKQELPPY B2CKC5_HUMAN B2CKC5_HUMAN IVGKSLTILGRTFFIYDCDPFTRRYYKEKFGITD-LPRIDVSKRE-P---PPVKQELPPY EFHC1_HUMAN EFHC1_HUMAN IVGKSLTILGRTFFIYDCDPFTRRYYKEKFGITD-LPRIDVSKRE-P---PPVKQELPPY B4DMU3_HUMAN B4DMU3_HUMAN IVGKSLTILGRTFFIYDCDPFTRRYYKEKFGITD-LPRIDVSKRE-P---PPVKQELPPY Q32TG2_CHICK Q32TG2_CHICK AVGKPTTLLGRTFFIYDCDEFTRNFYRDKFGITD-FQPVEIKKKP-P---EEIPQVIPPY Q66IK9_XENTR Q66IK9_XENTR KVGKHISILGRKFFIYDCDAYTRDFYRDKMGIGD-LQPVEVNKER-EDEEEKVIQEIPPY Q6DJD5_XENLA Q6DJD5_XENLA SVGKHVNILGRKFFIYDCDAYTRDFYQEKMGVRD-LQPVEVKMDRVD---EKVIQEVPPY MATCH :* : ** ..: .** :*: :*: : . *** CONSENSUS ??G??????GR?????DCD?FT???Y??K?G??????????????????????????PPY

EFHC2_MOUSE EFHC2_MOUSE TGFGSEEDSFRSCVGLKPTPHRKNFKKFMELDSFGNISNILRYFGKLITHKCADVDRIFV Q059K2_MOUSE Q059K2_MOUSE TGFGSEEDSFRSCVGLKPTPHRKNFKKFMELDSFGNISNILRYFGKLITHKCADVDRIFV B1AL25_HUMAN B1AL25_HUMAN NGFGSEEDSLRNCIDLKPTPHRRNFKKFMEKDSYGSKSNILRFFAKLVTDKCVDLDRMFV A8KAA2_HUMAN A8KAA2_HUMAN NGFGSEEDSLRNCIDLKPTPHRRNFKKFMEKDSYGYKSNILRFFAKLVTDKCVDLDRMFV A8K572_HUMAN A8K572_HUMAN NGFGSEEDSLRNCIDLKPTPHRRNFKKFMEKDSYGSKSNILRFFAKLVTDKCVDLDRMFV EFHC2_HUMAN EFHC2_HUMAN NGFGSEEDSLRNCIDLKPTPHRRNFKKFMEKDSYGSKSNILRFFAKLVTDKCVDLDRMFV Q32TF6_CIOIN Q32TF6_CIOIN NGFGSEEDSLCSCMGLIPKPPQRDFIKFMEKD-----SNVLRLVAYMATDNPIDKDRKFI B8A5Q4_DANRE B8A5Q4_DANRE TGFGSEEDSLCSCQGLLPKPPQKDFKKLMEKDRQGLVSNVLRFVGKMLTDSPVDKERVFI EFHC2_DANRE EFHC2_DANRE TGFGSEEDSLCSCQGLLPKPPQKDFKKLMEKDRRGLVSNVLRFVGKMLTDSPVDKERVFI B5DEU8_XENTR B5DEU8_XENTR NGFGSEADTLCSCMALLPKPPQRDFKKFMEKDRNGLESNVLRFVARLDTDNPIDKERKFI EFHC2_CHICK EFHC2_CHICK TGFGSEEDSLCSCMSLLPKPPQKDFKKFMEKDRCGLESNTLRFLAKLVTDSPIDKDRKFI Q7T2F1_DANRE Q7T2F1_DANRE NGFGSLEDSLQNCLSLIPQPPKKNVIKLLEND-----HKVLRYAARLDSQNPLDEGRRFI Q32TF7_CIOIN Q32TF7_CIOIN NGFGSLEDSLQNCLSLVPQPPKKDFIKMLEND-----HKILRYEAAMDSVRQEDRNRRFI B2CKC6_MOUSE B2CKC6_MOUSE NGYGLIEDSAQNCFALIPKAPRKDVVKMLMND-----NKVLRYLAALESPIPEDKDRRFV EFHC1_MOUSE EFHC1_MOUSE NGYGLIEDSAQNCFALIPKAPRKDVVKMLMND-----NKVLRYLAALESPIPEDKDRRFV B7Z2S4_HUMAN B7Z2S4_HUMAN NGFGLVEDSAQNCFALIPKAPKKDVIKMLVND-----NKVLRYLAVLESPIPEDKDRRFV Q4R667_MACFA Q4R667_MACFA NGFGLVEDSAQNCFALIPKAPKKDVIKMLVND-----NKVLRYLAALESPIPEDKDRRFV B2CKC5_HUMAN B2CKC5_HUMAN NGFGLVEDSAQNCFALIPKAPKKDVIKMLVND-----NKVLRYLAVLESPIPEDKDRRFV EFHC1_HUMAN EFHC1_HUMAN NGFGLVEDSAQNCFALIPKAPKKDVIKMLVND-----NKVLRYLAVLESPIPEDKDRRFV B4DMU3_HUMAN B4DMU3_HUMAN NGFGLVEDSAQNCFALIPKAPKKDVIKMLVND-----NKVLRYLAVLESPIPEDKDRRFV Q32TG2_CHICK Q32TG2_CHICK NGYGFLEDSLQNCYSLFPKRPRKDVIKMLEND-----HKVLRYQVALESPNPVDTKRRFI Q66IK9_XENTR Q66IK9_XENTR NGFGLLEDSLQNCLSLVPKPPKKDVLKMLEND-----HNVLRYVVILDSPNPEDKVRRFV Q6DJD5_XENLA Q6DJD5_XENLA NGFGLLEDSLQNCLSLVPKPPKKDVLKMLEND-----HNVLRYAVILDSPNPEDKVRRFV MATCH .*:* *: .* * * :::. *:: * : ** : : * * *: CONSENSUS ?GFG??EDS???C??L?P????????K????D????????LR????L??????D??R?F?

EFHC2_MOUSE EFHC2_MOUSE IAFYLSDDTISVFEPIENNSGNAGGMFLKRSRVKKPGQEVFKSEFSEYIKAEELYIGATV Q059K2_MOUSE Q059K2_MOUSE IAFYLSDDTISVFEPIENNSGNAGGMFLKRSRVKKPGQEVFKSEFSEYIKAEELYIGATV B1AL25_HUMAN B1AL25_HUMAN ISYYLGDDTISVFEPIERNSGIAGGMFLKRSRVKKPGQEVFKSELSEYIKAEELYIGVTV A8KAA2_HUMAN A8KAA2_HUMAN ISYYLGDDTISVFEPIERNSGIAGGMFLKRSRVKKPGQEVFKSELSEYIKAEELYIGVTV A8K572_HUMAN A8K572_HUMAN ISYYLGDDTISVFEPIERNSGIAGGMFLKRSRVKKPGQEVFKSELSEYIKAEELYIGVTV EFHC2_HUMAN EFHC2_HUMAN ISYYLGDDTISVFEPIERNSGIAGGMFLKRSRVKKPGQEVFKSELSEYIKAEELYIGVTV Q32TF6_CIOIN Q32TF6_CIOIN VSYFLSDDTISFFEPPQRNSGIIGGKFLERGRIKKPNQDLFKSEMSEYFTAADLFVGAKV B8A5Q4_DANRE B8A5Q4_DANRE ICFYLTDDTIAVFEPPQRNSGVIGGKFLERGRVKKPGQELFKSEMSEYFTAQDLYVGAHL EFHC2_DANRE EFHC2_DANRE ICFYLTDDTIAVFEPPQRNSGVIGGKFLERGRVKKPGQELFKSEMSEYFTAQDLYVGAHL B5DEU8_XENTR B5DEU8_XENTR VSYFLSDDTVTVFEPQERNSGMVGGKFLERSRVKKPGQQLFKSELSEYFRPEDLFVGARV EFHC2_CHICK EFHC2_CHICK ICYFLMMPLYSVFEHSQRNTGIIGGKFLEKGRIKKPGQELFKSEPSEYFKAQDLFIGARV Q7T2F1_DANRE Q7T2F1_DANRE LSFHLADDMISIFEKSTRNSGIIGGKFLEKTRIPKPGSTA---EKPEYYQPADLCVGATV Q32TF7_CIOIN Q32TF7_CIOIN ISYRLSDDMISIFEPPQRNSGIIGGKFLEATRISKPGSDV---ENPEFYGPGDFAIGATI B2CKC6_MOUSE B2CKC6_MOUSE FSYFLATDMISIFEPPVRNSGIIGGKFLGRTKVVKSFSPV---DNPIYYSPSDFFIGAVI EFHC1_MOUSE EFHC1_MOUSE FSYFLATDMISIFEPPVRNSGIIGGKFLGRTKVVKSFSPV---DNPIYYSPSDFFIGAVI B7Z2S4_HUMAN B7Z2S4_HUMAN FSYFLATDMISIFEPPVRNSGIIGGKYLGRTKVVKPYSTV---DNPVYYGPSDFFIGAVI Q4R667_MACFA Q4R667_MACFA FSYFLATDMISIFEPPVRNSGIIGGKYLGRTKVVKPYSTV---DNPIYYGPSDFFIGAVI B2CKC5_HUMAN B2CKC5_HUMAN FSYFLATDMISIFEPPVRNSGIIGGKYLGRTKVVKPYSTV---DNPVYYGPSDFFIGAVI EFHC1_HUMAN EFHC1_HUMAN FSYFLATDMISIFEPPVRNSGIIGGKYLGRTKVVKPYSTV---DNPVYYGPSDFFIGAVI B4DMU3_HUMAN B4DMU3_HUMAN FSYFLATDMISIFEPPVRNSGIIGGKYLGRTKVVKPYSTV---DNPVYYGPSDFFIGAVI Q32TG2_CHICK Q32TG2_CHICK LSYFLSNDMISIYEPPVRNSGIIGGKYLGKTRVAKPGSTT---ENAEYYGPSDLTIGSTI Q66IK9_XENTR Q66IK9_XENTR LSYFLANDMLSIFERQVRNSGIIGGKFLEKSRVLVPGSTV---DNPIYYGPKDFTIGAAI Q6DJD5_XENLA Q6DJD5_XENLA LSYFLANDMLSIFERQVRNSGIIGGKFLEKTRVPVPGSTI---DNPIYYGPKDFTIGAAI MATCH ..: * :.:* .*:* ** :* :: . . : . : . :: :* : CONSENSUS ????L??D?IS?FEP??RNSG??GG??L????V?KP???????????Y????????G???

EFHC2_MOUSE EFHC2_MOUSE NINGYLFILLNADEYTLNYMENNTDKFPYSNFELAIQKLKQ-EKSKSREITQVFAAADYN Q059K2_MOUSE Q059K2_MOUSE NINGYLFILLNADEYTLNYMENNTDKFPYSNFELAIQKLKQ-EKSKSREITQVFAAADYN B1AL25_HUMAN B1AL25_HUMAN NVNGYLFRLLNADEYTLNYMEQNTDKYPFSNLKLALQKLKQ-EEGKSRELKQVFKAADSK A8KAA2_HUMAN A8KAA2_HUMAN NVNGYLFRLLNADEYTLNYMEQNTDKYPFSNLKLALQKLKQ-EEGKSRELKQVFKAADSK A8K572_HUMAN A8K572_HUMAN NVNGYLFRLLNADEYTLNYMEQNTDKYPFSNLKLALQKLKQ-EEGKSRELKQVFKAADSK EFHC2_HUMAN EFHC2_HUMAN NVNGYLFRLLNADEYTLNYMEQNTDKYPFSNLKLALQKLKQ-EEGKSRELKQVFKAADSK Q32TF6_CIOIN Q32TF6_CIOIN VFNNFDFVITDADEYAFRYMEQHSNEFPQANLSLILEKMRKATKEKSKDVKEFFVLNDPD B8A5Q4_DANRE B8A5Q4_DANRE LLNSQPFQLVDADDFTFSYMEQHADEFPKANIGTIISKVKSISEEQQKKVKQFFTMSDPS EFHC2_DANRE EFHC2_DANRE LLNSQPFQLVDADDFTFSYMEQHADEFPKANIGTIISKVKSISEEQQKTVKQFFTMSDPS B5DEU8_XENTR B5DEU8_XENTR NFNGFLFILVDADEYVFNYMERNANEFPMSDISVITSKLRRIGETKSREIKQHFEANDPT EFHC2_CHICK EFHC2_CHICK CFHGHNFLLVDADEYTINYMEKHANEFAVADTGFIFKKLKDIAEPRSREIRQVFAAADPQ Q7T2F1_DANRE Q7T2F1_DANRE EVFGHRFVVTDADRFVLSFLESQSHQTPEHTLSSLRHATDP--QQLHPECDEAAVVQQS- Q32TF7_CIOIN Q32TF7_CIOIN QVFKHRFVITNCDEYVLKVLQQDADQYPVSTIQSIRTIHNKTPQEPNKE----------- B2CKC6_MOUSE B2CKC6_MOUSE EVFGHRFVILDTDEYVLKYMESNASQYSPEALASIQNRIQK-PELPAPELESKQATGEPM EFHC1_MOUSE EFHC1_MOUSE EVFGHRFVILDTDEYVLKYMESNASQYSPEALASIQNRIQK-PELPAPELESKQATGEPM B7Z2S4_HUMAN B7Z2S4_HUMAN EVFGHRFIILDTDEYVLKYMESNAAQYSPEALASIQNHVRK-REAPAPEAESKQTEKDPG Q4R667_MACFA Q4R667_MACFA EVFGHRFIILDTDEYVLKYMESNAAQYSPEALASVQKHVRK-LEAPASESESKQTEKDPG B2CKC5_HUMAN B2CKC5_HUMAN EVFGHRFIILDTDEYVLKYMESNAAQYSPEALASIQNHVRK-REAPAPEAESKQTEKDPG EFHC1_HUMAN EFHC1_HUMAN EVFGHRFIILDTDEYVLKYMESNAAQYSPEALASIQNHVRK-REAPAPEAESKQTEKDPG B4DMU3_HUMAN B4DMU3_HUMAN EVFGHRFIILDTDEYVLKYMESNAAQYSPEALASIQNHVRK-REAPAPEAESKQTEKDPG Q32TG2_CHICK Q32TG2_CHICK EVFGHRFIITDADEYVLNYMESNAESFPATTLQSMRDHFHP-RQVVEETAKSDVPAPGTS Q66IK9_XENTR Q66IK9_XENTR EVFNHRFIITDADEYVLNYMKAHSKEFPPHVLHSLERHLYP-----QPEI---------- Q6DJD5_XENLA Q6DJD5_XENLA EVFNHRFIITDADKYVLNYINAHSEEFPAHVLDSLQRHLHP-HNGKQ------------- MATCH . * : : * :.: :: .: . . CONSENSUS ??????F?????DEY???YME???????????????????????????????????????

EFHC2_MOUSE EFHC2_MOUSE HTKVVPYNTFRDILMSITMGKLIDQELITIARHYRVPEIMDPDLAYLIARAHEKFKKNIF Q059K2_MOUSE Q059K2_MOUSE HTKVVPYNTFRDILMSITMGKLIDQELITIARHYRVPEIMDPDLAYLIARAHEKFKKNIF B1AL25_HUMAN B1AL25_HUMAN HTNMVDYNTFRDILMSLTVGNLAEQEFVTIARHYRVPEGTCSDMDFLIALAHEKFKKNMF A8KAA2_HUMAN A8KAA2_HUMAN HTNMVDYNTFRDILMSLTVGNLAEQEFVTIARHYRVPEGTCSDMDFLIALAHEKFKKNMF A8K572_HUMAN A8K572_HUMAN HTNMVDYNTFRDILMSLTVGNLAEQEFVTIARHYRVPEGTCSDMDFLIALAHEKFKKNMF EFHC2_HUMAN EFHC2_HUMAN HTNMVDYNTFRDILMSLTVGNLAEQEFVTIARHYRVPEGTCSDMDFLIALAHEKFKKNMF Q32TF6_CIOIN Q32TF6_CIOIN NSGTIRYESLRNMLAQM--GSFSEHEIMTVGRHYAHREPEEVDMQLILAVAQEKLKKKNF B8A5Q4_DANRE B8A5Q4_DANRE STGSLPYESFRTLLADLDV-ELSEHEIMTLGRVYSVRQQPEVNVGLMLAVAQDHLKKKNF EFHC2_DANRE EFHC2_DANRE STGSLPYESFRTLLADLDV-ELSEHEIMTLGRVYSVRQQPEVNVGLMLAVAQDHLKKKNF B5DEU8_XENTR B5DEU8_XENTR GTSHMPYEIFRNLLVDIYANQLTEHEIMTTGRYYSIRDKPEIDLGSLTAIAQEQLKKKSF EFHC2_CHICK EFHC2_CHICK HTKVIEYDPFRNLIVSITDGAFSEHEIMTLGRHYGEKEEYEIDHHFLLAKAQEQLKKNSF Q7T2F1_DANRE Q7T2F1_DANRE ------------------------------------------------------------ Q32TF7_CIOIN Q32TF7_CIOIN ------------------------------------------------------------ B2CKC6_MOUSE B2CKC6_MOUSE VQGT--------------------------------EESKVQDLDALIDQIHMHLKYNSC EFHC1_MOUSE EFHC1_MOUSE VQGT--------------------------------EESKVQDLDALIDQIHMHLKYNSY B7Z2S4_HUMAN B7Z2S4_HUMAN V----------------------------------------QELEALIDTIQKQLKDHSC Q4R667_MACFA Q4R667_MACFA V----------------------------------------QELEALIDTIQKQLKDHSC B2CKC5_HUMAN B2CKC5_HUMAN V----------------------------------------QELEALIDTIQKQLKDHSC EFHC1_HUMAN EFHC1_HUMAN V----------------------------------------QELEALIDTIQKQLKDHSC B4DMU3_HUMAN B4DMU3_HUMAN V----------------------------------------QELEALIDTIQKQLKDHSC Q32TG2_CHICK Q32TG2_CHICK K----------------------------------------QELDELIARVQEELKLHNY Q66IK9_XENTR Q66IK9_XENTR ------------------------------------------------------------ Q6DJD5_XENLA Q6DJD5_XENLA ------------------------------------------------------------ MATCH CONSENSUS ???????????????????????????????????????????????????????K????

EFHC2_MOUSE EFHC2_MOUSE ENFDMFIYNCVYEDREKKGVLPTKDIRRMCKSSRLPLDDDFLDCLLSRFEDKDHQINYEI Q059K2_MOUSE Q059K2_MOUSE ENFDMFIYNCVYEDREKKGVLPTKDIRRMCKSSRLPLDDDFLDCLLSRFEDKDHQINYEI B1AL25_HUMAN B1AL25_HUMAN ENFDTFIYSCVYEDREKKNVLPTKDIKRLCKSSRLPLSDDLLESLLSRFEDSEKQIDYKS A8KAA2_HUMAN A8KAA2_HUMAN ENFDTFIYSCVYEDREKKNVLPTKDIKRLCKSSRLPLSDDLLESLLSRFEDSEKQIDYKS A8K572_HUMAN A8K572_HUMAN ENFDTFIYSCVYEDREKKNVLPTKDIKRLCKSSRLPLSDDLLESLLSRFEDSEKQIDYKS EFHC2_HUMAN EFHC2_HUMAN ENFDTFIYSCVYEDREKKNVLPTKDIKRLCKSSRLPLSDDLLESLLSRFEDSEKQIDYKS Q32TF6_CIOIN Q32TF6_CIOIN EDFVRLQEAFSFEDCGNTGKLAAGELRTICRAFKFPLPEDVLQLLIKKLSC-EGRVDYND B8A5Q4_DANRE B8A5Q4_DANRE EKFSEMIQAFTHEDRDRCGQLSSKEARIICKAFRLPLSDDLLRALLEKFAGESEKIDYHA EFHC2_DANRE EFHC2_DANRE EKFSEMIQAFTHEDRDRCGQLSSKEARIICKAFRLPLSDDLLRALLEKFAGESEKIDYHA B5DEU8_XENTR B5DEU8_XENTR ENFSKLSDVFVYNDQEKNGWLSFQKTLTICKAFKIPLADDFLRVLLEKHTENGDQVNYIS EFHC2_CHICK EFHC2_CHICK ENFEQLSTILVYNDREKCGALPYETCRTICKSFKLPLSDDLLQTILTMFEDDHKQVNYKK Q7T2F1_DANRE Q7T2F1_DANRE ------------------------------------------------------------ Q32TF7_CIOIN Q32TF7_CIOIN ------------------------------------------------------------ B2CKC6_MOUSE B2CKC6_MOUSE KE--NLRETFQMYDKDESGYVDRETFFKICETLNVPVDDSLIKELIRLCTHGEGRINYYN EFHC1_MOUSE EFHC1_MOUSE KE--NLRETFQMYDKDESGYVDRETFFKICETLNVPVDDSLIKELIRLCTHGEGRINYYN B7Z2S4_HUMAN B7Z2S4_HUMAN KD--NIREAFQIYDKEASGYVDRDMFFKICESLNVPVDDSLVKEVTCK----------RL Q4R667_MACFA Q4R667_MACFA KD--NIREAFQIYDKEASGYVDRDMFFKICESLNVPVDDSLVKELIRMCSHGEGKINYYN B2CKC5_HUMAN B2CKC5_HUMAN KD--NIREAFQIYDKEASGYVDRDMFFKICESLNVPVDDSLVKELIRMCSHGEGKINYYN EFHC1_HUMAN EFHC1_HUMAN KD--NIREAFQIYDKEASGYVDRDMFFKICESLNVPVDDSLVKELIRMCSHGEGKINYYN B4DMU3_HUMAN B4DMU3_HUMAN KD--NIREAFQIYDKEASGYVDRDMFFKICESLNVPVDDSLVKELIRMCSHGEGKINYYN Q32TG2_CHICK Q32TG2_CHICK LNYSNIREALLRSDKDESGFLNRAKFLSVCDSLNVPTSAVLVNKLIDLCSCGDDKINYRD Q66IK9_XENTR Q66IK9_XENTR ------------------------------------------------------------ Q6DJD5_XENLA Q6DJD5_XENLA -----------------------------------------------IHGIGETNI---- MATCH CONSENSUS ?????????????D???????????????C?????P????????????????????????

EFHC2_MOUSE EFHC2_MOUSE FFSVLNWRMNPTPDLQAPPYLKEKCEDVWVG--MPSPIPVKYVRYLDFLIDVYGLEDNML Q059K2_MOUSE Q059K2_MOUSE FFSVLNWRMNPTPDLQAPPYLKEKCEDVWVG--MPSPIPVKYVRYLDFLIDVYGLEDNML B1AL25_HUMAN B1AL25_HUMAN FFSALNWRKNPVPELQPASYLKERCEDVWLG--MPSPIPAKYIDYWTFLKDAFGLEEE-- A8KAA2_HUMAN A8KAA2_HUMAN FFSALNWRKNPVPELQPASYLKERCEDVWLG--MPSPIPAKYIDYWTFLKDAFGLEEE-- A8K572_HUMAN A8K572_HUMAN FFSALNWRKNPVPELQPASYLKERCEDVWLG--MPSPIPAKYIDYWTFLKDAFGLEEE-- EFHC2_HUMAN EFHC2_HUMAN FFSALNWRKNPVPELQPASYLKERCEDVWLG--MPSPIPAKYIDYWTFLKDAFGLEEE-- Q32TF6_CIOIN Q32TF6_CIOIN FVSKLNWRENPVEAVQYQN-LPIKFDASWSGGDLTKSASVSKVGYASLIEDIFGKQDS-- B8A5Q4_DANRE B8A5Q4_DANRE FLSGINWRENPVPAVLPED--TVKFDADWRG--EAPEPAVKTINYSLLLEDVFGSATNIN EFHC2_DANRE EFHC2_DANRE FLSGINWRENPVPAVLPED--TVKFDADWRG--EAPEPAVKTINYSLLLEDVFGSATNIN B5DEU8_XENTR B5DEU8_XENTR LVTGLNWRENPTAAQKTAP---VKYDPDWSG--QATANAVNNVNVLLLLDDLFGIEK--- EFHC2_CHICK EFHC2_CHICK FVDAVNWREHQIPSFHTIK-LPPKNEDDWNG--QPPFLPVKRIKYLPLLDDLFGKEE--- Q7T2F1_DANRE Q7T2F1_DANRE ------------------------------------------------------------ Q32TF7_CIOIN Q32TF7_CIOIN ------------------------------------------------------------ B2CKC6_MOUSE B2CKC6_MOUSE FVRAFSN----------------------------------------------------- EFHC1_MOUSE EFHC1_MOUSE FVRAFSN----------------------------------------------------- B7Z2S4_HUMAN B7Z2S4_HUMAN LLPAFTF---PSPVWIPLCGL--------------------------------------- Q4R667_MACFA Q4R667_MACFA FVRAFSN----------------------------------------------------- B2CKC5_HUMAN B2CKC5_HUMAN FVRAFSN----------------------------------------------------- EFHC1_HUMAN EFHC1_HUMAN FVRAFSN----------------------------------------------------- B4DMU3_HUMAN B4DMU3_HUMAN FVRAFSN----------------------------------------------------- Q32TG2_CHICK Q32TG2_CHICK FLRAF------------------------------------------------------- Q66IK9_XENTR Q66IK9_XENTR ------------------------------------------------------------ Q6DJD5_XENLA Q6DJD5_XENLA ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

EFHC2_MOUSE EFHC2_MOUSE -- Q059K2_MOUSE Q059K2_MOUSE -- B1AL25_HUMAN B1AL25_HUMAN -- A8KAA2_HUMAN A8KAA2_HUMAN -- A8K572_HUMAN A8K572_HUMAN -- EFHC2_HUMAN EFHC2_HUMAN -- Q32TF6_CIOIN Q32TF6_CIOIN -- B8A5Q4_DANRE B8A5Q4_DANRE DS EFHC2_DANRE EFHC2_DANRE DS B5DEU8_XENTR B5DEU8_XENTR -- EFHC2_CHICK EFHC2_CHICK -- Q7T2F1_DANRE Q7T2F1_DANRE -- Q32TF7_CIOIN Q32TF7_CIOIN -- B2CKC6_MOUSE B2CKC6_MOUSE -- EFHC1_MOUSE EFHC1_MOUSE -- B7Z2S4_HUMAN B7Z2S4_HUMAN -- Q4R667_MACFA Q4R667_MACFA -- B2CKC5_HUMAN B2CKC5_HUMAN -- EFHC1_HUMAN EFHC1_HUMAN -- B4DMU3_HUMAN B4DMU3_HUMAN -- Q32TG2_CHICK Q32TG2_CHICK -- Q66IK9_XENTR Q66IK9_XENTR -- Q6DJD5_XENLA Q6DJD5_XENLA -- MATCH CONSENSUS ??


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