Alignment of the gene Family HBG059673 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
Q4S4E9_TETNG Q4S4E9_TETNG ------------------------------------------------------------ B4E3N5_HUMAN B4E3N5_HUMAN SEARRD-------STSSLQRKKPPWLKLDIPSA--VPLTAEEPSFLQ------------- B4E3Q0_HUMAN B4E3Q0_HUMAN SEARRD-------STSSLQRKKPPWLKLDIPSA--VPLTAEEPSFLQVGPGLQGLWVPPV B3EX26_SORAR B3EX26_SORAR SEARRD-------STSSLQRKKPSWLKLDIPVA--VPPTPEEPSSMQTAVPLP------- B3KPT2_HUMAN B3KPT2_HUMAN SEARRD-------STSSLQRKKPPWLKLDIPSA--V------------------------ RHDF1_HUMAN RHDF1_HUMAN SEARRD-------STSSLQRKKPPWLKLDIPSA--VPLTAEEPSFLQ------------- RHDF1_PAPAN RHDF1_PAPAN SEARRD-------STSSLQRKKPPWLKLDIPSA--VPPTAEEPSFLQ------------- RHDF1_CALJA RHDF1_CALJA SEARRD-------STSSLQRKKPPWLKLDIPSA--APATAEEPSFLQ------------- RHDF1_CALMO RHDF1_CALMO SEARRD-------STSSLQRKKPPWLKLDIPSA--APPAAEEPSFLQ------------- B2KHV7_RHIFE B2KHV7_RHIFE SEVRRD-------STSSLQRKKPPWLKLDIPAV--APPAAEEPSFLQ------------- RHDF1_MOUSE RHDF1_MOUSE SEARRD-------STSSLQRKKPPWLKLDIPAA--VPPAAEEPSFLQ------------- RHDF1_RAT RHDF1_RAT SEARRD-------STSSLQRKKPPWLKLDIPAV--VPPAAEEPSFLQ------------- RHDF1_BOVIN RHDF1_BOVIN GEARRD-------SSSSLQHKKPPWLKLDIPAV--VPPAAEEPSFLQ------------- B8K128_RABIT B8K128_RABIT SECRRD-------STSSLQRKKPPWLKLDIPAV--APPAAEEPSVLQ------------- RHDF1_DANRE RHDF1_DANRE AELRRD-------STSSLQRKKPPWLKLDIPTA--HVSVDEVPAFVP------------- Q4RHC6_TETNG Q4RHC6_TETNG AEPQRE-------STSSLQRKKPPWLRLDIPTA--QMSLDEPSTFVQ------------- Q8UV20_9PERC Q8UV20_9PERC ------------------------------------------------------------ RHDF2_XENTR RHDF2_XENTR ASLKKNG------SSSRLQDRKPPNLSITIPPV----EGERDPKLMQ------------- Q6ZWP8_HUMAN Q6ZWP8_HUMAN GSSRSRHPLLL--LIWSLGSSQGPHRQIRPPPP--------------------------- RHDF2_MOUSE RHDF2_MOUSE ASADKNGSNLPSVSGSRLQSRKPPNLSITIPPP--ESQAPGEQDSML------------- RHDF2_CANFA RHDF2_CANFA DSTDKNGESVSSVSSSRLQSRKPPNLSITIPPP--EASAPGEQASML------------- B7Z8H4_HUMAN B7Z8H4_HUMAN ASADKNGGSVSSVSSSRLQSRKPPNLSITIPPPEKETQAPGEQDSML------------- RHDF2_HUMAN RHDF2_HUMAN ASADKNGGSVSSVSSSRLQSRKPPNLSITIPPPEKETQAPGEQDSML------------- MATCH CONSENSUS ?????????????S?S?LQ??KPP?L???IP?????????????????????????????

Q4S4E9_TETNG Q4S4E9_TETNG ------------------------------------------------------------ B4E3N5_HUMAN B4E3N5_HUMAN ----------PL------------------------------RRQAFLRSVSMPAETAHI B4E3Q0_HUMAN B4E3Q0_HUMAN QYPHHDPVAQPL------------------------------RRQAFLRSVSMPAETAHI B3EX26_SORAR B3EX26_SORAR ----RDPAAQPL------------------------------RRQAFLRSVSMPAEAAHI B3KPT2_HUMAN B3KPT2_HUMAN ----------PL------------------------------RRQAFLRSVSMPAETAHI RHDF1_HUMAN RHDF1_HUMAN ----------PL------------------------------RRQAFLRSVSMPAETAHI RHDF1_PAPAN RHDF1_PAPAN ----------PL------------------------------RRQAFLRSVSMPAETAHI RHDF1_CALJA RHDF1_CALJA ----------PL------------------------------RRQVFLRSVSMPAETAHI RHDF1_CALMO RHDF1_CALMO ----------PL------------------------------RRQVFLRSVSMPAETAHI B2KHV7_RHIFE B2KHV7_RHIFE ----------PL------------------------------RRQAFLRSVSMPAETAHV RHDF1_MOUSE RHDF1_MOUSE ----------PL------------------------------RRQAFLRSVSMPAETARV RHDF1_RAT RHDF1_RAT ----------PL------------------------------RRQAFLRSVSMPAETARV RHDF1_BOVIN RHDF1_BOVIN ----------PL------------------------------RRQAFLRSVSMPAEPARV B8K128_RABIT B8K128_RABIT ----------PL------------------------------RRQAFLRSVSMPAETAHV RHDF1_DANRE RHDF1_DANRE ----------PV------------------------------KRQGFHRSASMPVETSHF Q4RHC6_TETNG Q4RHC6_TETNG ----------PT------------------------------KRQGFLRSISMPVETTHL Q8UV20_9PERC Q8UV20_9PERC ------------------------------------------------------------ RHDF2_XENTR RHDF2_XENTR ----------PL------------------------------TKPVFQKSVSLQEPRGHV Q6ZWP8_HUMAN Q6ZWP8_HUMAN ------------------------------------------CRHA----------GTHV RHDF2_MOUSE RHDF2_MOUSE ----------PE----------------------------RRKNPAYLKSVSLQEPRGRW RHDF2_CANFA RHDF2_CANFA ----------PQ----------------------------RPRNPAYMKSVSLQEQRGRW B7Z8H4_HUMAN B7Z8H4_HUMAN ----------PE-----------------------------RKNPAYLKSVSLQEPRSRW RHDF2_HUMAN RHDF2_HUMAN ----------PEGFQNRRLKKSQPRTWAAHTTACPPSFLPKRKNPAYLKSVSLQEPRSRW MATCH CONSENSUS ??????????P??????????????????????????????????????S?S????????

Q4S4E9_TETNG Q4S4E9_TETNG ----------------------QTLA---------------------------------- B4E3N5_HUMAN B4E3N5_HUMAN SSPHHEL---RRPVLQRQTSITQTIR---------------------------------- B4E3Q0_HUMAN B4E3Q0_HUMAN SSPHHEL---RRPVLQRQTSITQTIR---------------------------------- B3EX26_SORAR B3EX26_SORAR SSPHHEP---RRPALQRQMSITQTIR---------------------------------- B3KPT2_HUMAN B3KPT2_HUMAN SSPHHEL---RRPVLQRQTSITQTIR---------------------------------- RHDF1_HUMAN RHDF1_HUMAN SSPHHEL---RRPVLQRQTSITQTIR---------------------------------- RHDF1_PAPAN RHDF1_PAPAN SSPHHEL---RRSVLQRQTSITQTIR---------------------------------- RHDF1_CALJA RHDF1_CALJA SSPHYEL---RRPVLQRQTSITQTIR---------------------------------- RHDF1_CALMO RHDF1_CALMO SSPHCEL---RRPVLQRQTSITQTIR---------------------------------- B2KHV7_RHIFE B2KHV7_RHIFE PSPYHEP---RRPVLQRQISITQTIR---------------------------------- RHDF1_MOUSE RHDF1_MOUSE PSPHHEP---RRLVLQRQTSITQTIR---------------------------------- RHDF1_RAT RHDF1_RAT PSPHHEP---RRLALQRQTSITQTIR---------------------------------- RHDF1_BOVIN RHDF1_BOVIN PSPHQEP---RRPVLQRQMSITQTIR---------------------------------- B8K128_RABIT B8K128_RABIT PCAHPEP---RRPVLQRQASITQTIR---------------------------------- RHDF1_DANRE RHDF1_DANRE HSPQRDIIDHRRAAFQRQSSITQTIK---------------------------------- Q4RHC6_TETNG Q4RHC6_TETNG QSPPRDFFDTRRPVLQRQPSITQTIKSSRRVHFERINTVPVKGQRAARRSTRRHHSLSRT Q8UV20_9PERC Q8UV20_9PERC ------------------------------------------------------------ RHDF2_XENTR RHDF2_XENTR AEGGTAD---VRPGFKRQTSLSQSIK---------------------------------- Q6ZWP8_HUMAN Q6ZWP8_HUMAN PSPLPHTQVHRRRQAYAHLSLV-CFR---------------------------------- RHDF2_MOUSE RHDF2_MOUSE QEGAE-----KRPGFRRQASLSQSIR---------------------------------- RHDF2_CANFA RHDF2_CANFA QEGSSE----KRPGFRRQASLSQSIR---------------------------------- B7Z8H4_HUMAN B7Z8H4_HUMAN QESSE-----KRPGFRRQASLSQSIR---------------------------------- RHDF2_HUMAN RHDF2_HUMAN QESSE-----KRPGFRRQASLSQSIR---------------------------------- MATCH CONSENSUS ???????????R????RQ?S??Q?I???????????????????????????????????

Q4S4E9_TETNG Q4S4E9_TETNG --EGTA------------------------------------------------------ B4E3N5_HUMAN B4E3N5_HUMAN --RGTADWFGVSKDSDST-QKWQRKSIRHCSQRYGKLKPQVLRELDLPSQDNVSLTSTET B4E3Q0_HUMAN B4E3Q0_HUMAN --RGTADWFGVSKDSDST-QKWQRKSIRHCSQRYGKLKPQVLRELDLPSQDNVSLTSTET B3EX26_SORAR B3EX26_SORAR --RGTADWFGVSKDSDST-QKWQRKSLRHCSQRYGRLKPQVMRELDLPSQDNVSLTSTET B3KPT2_HUMAN B3KPT2_HUMAN --RGTADWFGVSKDIDST-QKWQRKSIRHCSQRYGKLKPQVLRELDLPSQDNVSLTSTET RHDF1_HUMAN RHDF1_HUMAN --RGTADWFGVSKDSDST-QKWQRKSIRHCSQRYGKLKPQVLRELDLPSQDNVSLTSTET RHDF1_PAPAN RHDF1_PAPAN --RGTADWFGVSKDSDST-QKWQRKSIRHCSQRYGKLKPQVLRELDLPSQDNVSLTSTET RHDF1_CALJA RHDF1_CALJA --RGAADWFGVSKESDST-QKWQRKSIRHCSQRYGKLKPQVLRELDLPSQDNVSLTSTET RHDF1_CALMO RHDF1_CALMO --RGAADWFGVSKESEST-QKWQRKSIRHCSQRYGKLKPQVLRELDLPSQDNVSLTSTET B2KHV7_RHIFE B2KHV7_RHIFE --RGTADWFGVSKDSDST-QKWQRKSIRHCSQRYGKLKPQVMRELDLPSQDNVSLTSTET RHDF1_MOUSE RHDF1_MOUSE --RGTADWFGVSKDSDST-QKWQRKSIRHCSQRYGKLKPQVIRELDLPSQDNVSLTSTET RHDF1_RAT RHDF1_RAT --RGTADWFGVSKDSDST-QKWQRKSIRHCSQRYGKLKPQVIRELDLPSQDNVSLTSTET RHDF1_BOVIN RHDF1_BOVIN --RGTADWFGVSKDSDST-QKWQRKSIRHCSQRYGKLKPQVIRELDLPSQDNVSLTSTET B8K128_RABIT B8K128_RABIT --RGTADWFGVSKDSDST-QKWQRKSIRHCSQRYGKLKPQVIRELDLPSQDNVSLTSTET RHDF1_DANRE RHDF1_DANRE --RGTADWFGVSKDGDAT-QKWQRKSLRHCSLRYGKLKPQVIREMELPSQDNISLTSTET Q4RHC6_TETNG Q4RHC6_TETNG LLRGTADWFGVSKDSDST-QRWQRKSLRHCSMRYGKLKPQVIREMDLPSQDNISLTSTET Q8UV20_9PERC Q8UV20_9PERC --RGTADWFGVSKDGDST-QRWQRKSLRHCSLRYGKLKPQVLREMDLPSQDNISLTSTET RHDF2_XENTR RHDF2_XENTR --RGTAQWFGVSNDWEGKRQQWQRKSLHHCSLRYGKLKPQYQRDIELPSQETPSFQATES Q6ZWP8_HUMAN Q6ZWP8_HUMAN --RGAAQWFGVSGDWEGQRQQWQRRSLHHCSMRYGRLKASCQRDLELPSQEAPSFQGTES RHDF2_MOUSE RHDF2_MOUSE --KSTAQWFGVSGDWEGKRQNWHRRSLHHCSVHYGRLKASCQRELELPSQEVPSFQGTES RHDF2_CANFA RHDF2_CANFA --KGTAQWFGVSGDWEAKRQHWQRRSLHHCSVRYGRLKASCQRDLELPSQEVPSFQGTES B7Z8H4_HUMAN B7Z8H4_HUMAN --KGAAQWFGVSGDWEGQRQQWQRRSLHHCSMRYGRLKASCQRDLELPSQEAPSFQGTES RHDF2_HUMAN RHDF2_HUMAN --KGAAQWFGVSGDWEGQRQQWQRRSLHHCSMRYGRLKASCQRDLELPSQEAPSFQGTES MATCH ..:* CONSENSUS ???G?A?WFGVS?D?????Q?WQR?S??HCS?RYG?LK????R???LPSQ???S???TE?

Q4S4E9_TETNG Q4S4E9_TETNG ---------------------------------------H-------------------- B4E3N5_HUMAN B4E3N5_HUMAN PPPLYVGPCQLGMQKIIDPLARGRAFRVADDTAEGLSAPH---TPVTPGAASLCSFSSSR B4E3Q0_HUMAN B4E3Q0_HUMAN PPPLYVGPCQLGMQKIIDPLARGRAFRVADDTAEGLSAPH---TPVTPGAASLCSFSSSR B3EX26_SORAR B3EX26_SORAR PPPLYVGPCQLGMQKIIDPLARGRAFRVADDAADGLSTPH---TPITPGAASLCSFSSSR B3KPT2_HUMAN B3KPT2_HUMAN PPPLYVGPCQLGMQKIIDPLARGRAFRVADDTVEGLSAPH---TPVTPGAASLCSFSSSR RHDF1_HUMAN RHDF1_HUMAN PPPLYVGPCQLGMQKIIDPLARGRAFRVADDTAEGLSAPH---TPVTPGAASLCSFSSSR RHDF1_PAPAN RHDF1_PAPAN PPPLYVGPCQLGMQKIIDPLARGRAFRVADDTAEGLSAPH---TPVTPGAASLCSFSSSR RHDF1_CALJA RHDF1_CALJA PPPLYVGPCQLGMQKIIDPLARGRAFRVADDTAEGLSAPH---TPVTPGAASLCSFSSSR RHDF1_CALMO RHDF1_CALMO PPPLYVGPCQLGMQKIIDPLARGRAFRVADDAAEGLSAPH---TPVTPGAASLCSFSSSR B2KHV7_RHIFE B2KHV7_RHIFE PPPLYVGPCQLGMQKIIDPLARGRAFRMADDTADGLSTPH---TPVTPGAASLCSFSSSR RHDF1_MOUSE RHDF1_MOUSE PPPLYVGPCQLGMQKIIDPLARGRAFRMADDTADGLSAPH---TPVTPGAASLCSFSSSR RHDF1_RAT RHDF1_RAT PPPLYVGPCQLGMQKIIDPLARGRAFRMADDTADGLSAPH---TPVTPGAASLCSFSSSR RHDF1_BOVIN RHDF1_BOVIN PPPLYVGPCQLGMQKIVDPLARGRAFRLADDAADGPSAPH---TPVTPGAASLCSFSSSR B8K128_RABIT B8K128_RABIT PPPLYVGPCQLGMQKIIDPLARGRAFRVADDAADGLSAPH---TPITPGAASLCSFSSSR RHDF1_DANRE RHDF1_DANRE PPPLYVPSSQHGMQKIVDPLARGRAFRMVEE-VDGYSVPQ---TPITPGAASICSFNSSR Q4RHC6_TETNG Q4RHC6_TETNG PPPLYVPSSQHGMQKIVDPLARGRAFRMVEE-VDGYSVPQ---TPITPGAASLCSFTSSR Q8UV20_9PERC Q8UV20_9PERC PPPLYVSSSQHGMQKIVDPLARGRAFRMVEE-VDGYSVPQ---TPITPGAASLCSFTSSR RHDF2_XENTR RHDF2_XENTR P-------ATHRLPKIVDPLARGRPFRHPDE-VDRPRTPHVGLPPQTPGMLSLASFTSVR Q6ZWP8_HUMAN Q6ZWP8_HUMAN PKP-----CK--MPKIVDPLARGRAFRHPEE-MDRPHALH---PPLTPGVLSLTSFTSVR RHDF2_MOUSE RHDF2_MOUSE PKP-----CK--MPKIVDPLARGRAFRHPDE-VDRPHAAH---PPLTPGVLSLTSFTSVR RHDF2_CANFA RHDF2_CANFA PKP-----CK--MPKIVDPLARGRAFRHPDE-VDRPHAPH---PPLTPGVLSLTSFTSVR B7Z8H4_HUMAN B7Z8H4_HUMAN PKP-----CK--MPKIVDPLARGRAFRHPEE-MDRPHALH---PPLTPGVLSLTSFTSVR RHDF2_HUMAN RHDF2_HUMAN PKP-----CK--MPKIVDPLARGRAFRHPEE-MDRPHAPH---PPLTPGVLSLTSFTSVR MATCH : CONSENSUS P?P?????????M?KI?DPLARGRAFR???????????PH????P?TPG??SL?SF?S?R

Q4S4E9_TETNG Q4S4E9_TETNG ------PRRR----------------------------------RSFMPPSFFEEESVDC B4E3N5_HUMAN B4E3N5_HUMAN SGFHRLPRRRKRESVAKMSFRAAAALMKGRSVRDGTFRRAQ--RRSFTPASFLEEDTTDF B4E3Q0_HUMAN B4E3Q0_HUMAN SGFHRLPRRRKRESVAKMSFRAAAALMKGRSVRDGTFRRAQ--RRSFTPASFLEEDTTDF B3EX26_SORAR B3EX26_SORAR SGFNRLPRRRKRESVAKMSFRAAAALVKGRSVRDGTLRRAQ--RRSFTPASFLEEDTAEF B3KPT2_HUMAN B3KPT2_HUMAN SGFHRLPRRRKRESVAKMSFRAAAALMKGRSVRDGTFRRAQ--RRSFTPASFLEEDTTDF RHDF1_HUMAN RHDF1_HUMAN SGFHRLPRRRKRESVAKMSFRAAAALMKGRSVRDGTFRRAQ--RRSFTPASFLEEDTTDF RHDF1_PAPAN RHDF1_PAPAN SGFHRLPRRRKRESVAKMSFRAAAALMKGRSVRDGTLRRAQ--RRSFTPASFLEEDTTDF RHDF1_CALJA RHDF1_CALJA SGFHRLPRRRKRESVAKMSFRAAAALMKGRSVRDGTLRRAQ--RRSFTPASFLEEDTTDF RHDF1_CALMO RHDF1_CALMO SGFHRLPRRRKRESVAKMSFRAAAALMKGRSVRDGTLRRAQ--RRSFTPASFLEEDTTDF B2KHV7_RHIFE B2KHV7_RHIFE SGFNRLPRRRKRESVAKMSFRAAAALVKGRSVRDGTLRRVQ--RRSFTPASFLEEDTADF RHDF1_MOUSE RHDF1_MOUSE SGFNRLPRRRKRESVAKMSFRAAAALVKGRSIRDGTLRRGQ--RRSFTPASFLEEDMVDF RHDF1_RAT RHDF1_RAT SGFNRLPRRRKRESVAKMSFRAAAALVKGRSIRDGTLRRGQ--RRSFTPASFLEEDMVDF RHDF1_BOVIN RHDF1_BOVIN SGFNRLPRRRKRESVAKMSFRAAAALVKGRSVRDGTLRRAQ--RRSFTPASFLEEDTADF B8K128_RABIT B8K128_RABIT SGFSRLPRRRKRESVAKMSFRAAAALVKGRSIRDGTLRRAQ--RRSFTPASFLEEDTADF RHDF1_DANRE RHDF1_DANRE SGLNRIPRRRKRESVAKMSFRAAAALVKGRSLREGTLRRAH--RRSFTPASFIEEDVVDF Q4RHC6_TETNG Q4RHC6_TETNG SGLNRPPRRRKRESVAKMSFRAAAALVKGRSIRESTLRRAQ--RRSFTPASFM-EDIVDF Q8UV20_9PERC Q8UV20_9PERC SGLNRLPRRRKRESVAKMSFRAAAALVKGRSIRESTLRRAQ--RRSFTPASFMEEDMVDF RHDF2_XENTR RHDF2_XENTR SGYSRFP-RRKRESVAHMSFRAAAALIKGRPILDTPHSRKAGQKRSFIYPSFMDEDTVDA Q6ZWP8_HUMAN Q6ZWP8_HUMAN SGYSHLP-RRKRMSVAHMSLQAAAALLKGRSVLDATGQRCRVVKRSFAFPSFLEEDVVDG RHDF2_MOUSE RHDF2_MOUSE SGYSHLP-RRKRISVAHMSFQAAAALLKGRSVLDATGQRCRHVKRSFAYPSFLEEDAVDG RHDF2_CANFA RHDF2_CANFA SGHSHLP-RRKRMSVAHMSFQAAAALLKGRSVLDATGQRCRVVKRSFAYPSFLEEDVVDG B7Z8H4_HUMAN B7Z8H4_HUMAN SGYSHLP-RRKRMSVAHMSLQAAAALLKGRSVLDATGQRCRVVKRSFAFPSFLEEDVVDG RHDF2_HUMAN RHDF2_HUMAN SGYSHLP-RRKRMSVAHMSLQAAAALLKGRSVLDATGQRCRVVKRSFAFPSFLEEDVVDG MATCH * ** *** .**: *: .: CONSENSUS SG???LP?RRKR?SVA?MSF?AAAAL?KGRS??D?T??R?????RSF???SF?EED??D?

Q4S4E9_TETNG Q4S4E9_TETNG LEDLDTSFFSGEG-LQDELSSYADDVFETASEAALKQ------VDESELTGSALDKCDLE B4E3N5_HUMAN B4E3N5_HUMAN PDELDTSFFAREGILHEELSTYPDEVFESPSEAALKDWEKA--PEQADLTGGALDRSELE B4E3Q0_HUMAN B4E3Q0_HUMAN PDELDTSFFAREGILHEELSTYPDEVFESPSEAALKDWEKA--PEQADLTGGALDRSELE B3EX26_SORAR B3EX26_SORAR PEELDTSFFAREGVLHEELSTYPDEVFESPSEAALKDWEKA--PEQAGLTGGALDRSELE B3KPT2_HUMAN B3KPT2_HUMAN PDELDTSFFAREGILHEELSTYPDEVFESPSEAALKDWEKA--PEQADLTGGALDRSELE RHDF1_HUMAN RHDF1_HUMAN PDELDTSFFAREGILHEELSTYPDEVFESPSEAALKDWEKA--PEQADLTGGALDRSELE RHDF1_PAPAN RHDF1_PAPAN PDELDTSFFAREGILHEELSTYPDEVFESPSEAALKDWEKA--PEQADLTGGALDRSELE RHDF1_CALJA RHDF1_CALJA PDELDTSFFAREGILHEELSTYPDEVFESPSEAALKDWEKA--PEQADLTGGALDRSELE RHDF1_CALMO RHDF1_CALMO PDELDTSFFAREGILHEELSTYPDEVFESPSEAALKDWEKA--PEQADLTGGALDRSELE B2KHV7_RHIFE B2KHV7_RHIFE PDELDTSFFAREGVLHEELSTYPDEVFESPSEAALKEWEKA--PDQADLTGGALDRTELE RHDF1_MOUSE RHDF1_MOUSE PDELDTSFFAREGVLHEEMSTYPDEVFESPSEAALKDWEKA--PDQADLTGGALDRSELE RHDF1_RAT RHDF1_RAT PDELDTSFFAREGVLHEELSTYPDEVFESPSEAALKDWEKA--PDQADLTGGALDRSELE RHDF1_BOVIN RHDF1_BOVIN PDELDTSFFAREGVLHEELSTYPDEVFESPSEAALKDWERA--PEQVDLTGGALDRSELE B8K128_RABIT B8K128_RABIT PDELDTSFFAREGVLHEELSTYPDEVFESPSEAALKDWEKA--PEQAELTGGALDRSELE RHDF1_DANRE RHDF1_DANRE PDELDTSFFARDIMMHEEMSTFHDEVFESPSDSTMKDVDSK-QLDESELTGSALDKSELE Q4RHC6_TETNG Q4RHC6_TETNG PDELDTSFFARDILMHEELSTYADEVFESPSEAALKEVESSGKKDETELTGSALDKTELE Q8UV20_9PERC Q8UV20_9PERC PDELDTSFFARDVLMHEELSTYTDEVFESPSEAALKEVESNGKQDEPELTGSALDKTELE RHDF2_XENTR RHDF2_XENTR AETLDSSFFSKVD-MHDETFSMPDDVFDSP-------------PMSASYFRAPLPIPE-- Q6ZWP8_HUMAN Q6ZWP8_HUMAN ADTFDSSFFSK-----EEMSSMPDDVFESP-------------PLSASYFRGIPHSAS-- RHDF2_MOUSE RHDF2_MOUSE ADTFDSSFFSK-----EEMSSMPDDVFESP-------------PLSASYFRGVPHSAS-- RHDF2_CANFA RHDF2_CANFA ADTFDSSFFSK-----EEMSSMPDDVFESP-------------PLSASYFRGIPRSAS-- B7Z8H4_HUMAN B7Z8H4_HUMAN ADTFDSSFFSK-----EEMSSMPDDVFESP-------------PLSASYFRGIPHSAS-- RHDF2_HUMAN RHDF2_HUMAN ADTFDSSFFSK-----EEMSSMPDDVFESP-------------PLSASYFRGIPHSAS-- MATCH : :*:***: :* : *:**::. . . . CONSENSUS ?D??D?SFF???????EE?S??PD?VFESP?????????????P????????????????

Q4S4E9_TETNG Q4S4E9_TETNG RSHLMLPLERGWRKAKD--NSAVHPRVRLKQ---EVVSVNGHQQRGQRIAAPVQKL-FAR B4E3N5_HUMAN B4E3N5_HUMAN RSHLMLPLERGWRKQKE-GAAAPQPKVRLRQ---EVVSTAGPR-RGQRIAVPVRKL-FAR B4E3Q0_HUMAN B4E3Q0_HUMAN RSHLMLPLERGWRKQKE-GAAAPQPKVRLRQ---EVVSTAGPR-RGQRIAVPVRKL-FAR B3EX26_SORAR B3EX26_SORAR RSHLMLPLERGWRKQKEGCAGGPQPKVRLRQ---EVVSAAGQR-RGQRIAVPVRKF-FAR B3KPT2_HUMAN B3KPT2_HUMAN RSHLMLPLERGWRKQKE-GAAAPQPKVRLRQ---EVVSTAGPR-RGQRIAVPVRKL-FAR RHDF1_HUMAN RHDF1_HUMAN RSHLMLPLERGWRKQKE-GAAAPQPKVRLRQ---EVVSTAGPR-RGQRIAVPVRKL-FAR RHDF1_PAPAN RHDF1_PAPAN RSHLMLPLERGWRKQKE-GAAAPQPKVRLRQ---EVVSTAGPR-RGQRIAVPVRKL-FAR RHDF1_CALJA RHDF1_CALJA RSHLMLPLERGWRKQKE-GAAAQQPKVRLRQ---EVVSTAGPR-RGQRIAVPVRKL-FAR RHDF1_CALMO RHDF1_CALMO RSHLMLPLERGWRKQKE-GAAAPQPKVRLRQ---EVVSTAGPR-RGQRIAVPVRKL-FAR B2KHV7_RHIFE B2KHV7_RHIFE RSHLMLPLERGWRKQKEGGAAATQPKVRLRQ---EVVSAAGQR-RGQRIAMPVRKF-FAR RHDF1_MOUSE RHDF1_MOUSE RSHLMLPLERGWRKQKEGGPLAPQPKVRLRQ---EVVSAAGPR-RGQRIAVPVRKL-FAR RHDF1_RAT RHDF1_RAT RSHLMLPLERGWRKQKEGGTLAPQPKVRLRQ---EVVSAAGPR-RGQRIAVPVRKL-FAR RHDF1_BOVIN RHDF1_BOVIN RSHLMLPLERGWRKQKEGGAAAPQPKVRLRQ---EVVSTAGQR-RGQRIAMPVRKL-FAR B8K128_RABIT B8K128_RABIT RSHLMLPLERGWRKQKDGGAVAPQPKVRLRQ---EVVSPPGAR-RGQRIAVPVRKL-FAR RHDF1_DANRE RHDF1_DANRE KSHLMLPLERGWRKVKE-KTPAP-PKIRLKQ---EVVSVNGQR-RGQRIGLPVKKL-FAR Q4RHC6_TETNG Q4RHC6_TETNG RSHLMLPLERGWRKAKY-GTPGP-PKVPLRQ---EVVSVTGQR-RGQRIVIPVKKL-FAR Q8UV20_9PERC Q8UV20_9PERC RSHLMLPLERGWRKAKE-GTPGP-PKVPLRQ---EVVSVTGQR-RGQRIVVPVKKL-FAR RHDF2_XENTR RHDF2_XENTR ---LMPGA------------AIEAAKEPVKS---VQVYTPDHR-RGKRIASQVKHFAFDR Q6ZWP8_HUMAN Q6ZWP8_HUMAN ------PV------------SPDGVQIPLKEY--GRAPVPGPR-RGKRIASKVKHFAFDR RHDF2_MOUSE RHDF2_MOUSE ------PV------------SPDGVHIPLKEYSGGRALGPGTQ-RGKRIASKVKHFAFDR RHDF2_CANFA RHDF2_CANFA ------PV------------SPDGVQIPLKEY--GRPPVAGTR-RGKRIASKVKHFAFDR B7Z8H4_HUMAN B7Z8H4_HUMAN ------PV------------SPDGVQIPLKEY--GRAPVPGPR-RGKRIASKVKHFAFDR RHDF2_HUMAN RHDF2_HUMAN ------PV------------SPDGVQIPLKEY--GRAPVPGPR-RGKRIASKVKHFAFDR MATCH : ::. . : **:** *::: * * CONSENSUS ??????P?????????????????????L???????????G?R?RG?RIA??V????F?R

Q4S4E9_TETNG Q4S4E9_TETNG EKRPYGLGMVGRLTNRTYRKRIDSFVRKQIEDMDDHR-PFFSYWITFVHLVITILAVTIY B4E3N5_HUMAN B4E3N5_HUMAN EKRPYGLGMVGRLTNRTYRKRIDSFVKRQIEDMDDHR-PFFTYWLTFVHSLVTILAVCIY B4E3Q0_HUMAN B4E3Q0_HUMAN EKRPYGLGMVGRLTNRTYRKRIDSFVKRQIEDMDDHR-PFFTYWLTFVHSLVTILAVCIY B3EX26_SORAR B3EX26_SORAR EKRPYGLGMVGRLTNRTYRKRIDSYVKRQIEDMDDHR-PFFTYWLTFVHSLVTILAVCIY B3KPT2_HUMAN B3KPT2_HUMAN EKRPYGLGMVGRLTNRTYRKRIDSFVKRQIEDMDDHR-PFFTYWLTFVHSLVTILAVCIY RHDF1_HUMAN RHDF1_HUMAN EKRPYGLGMVGRLTNRTYRKRIDSFVKRQIEDMDDHR-PFFTYWLTFVHSLVTILAVCIY RHDF1_PAPAN RHDF1_PAPAN EKRPYGLGMVGRLTNRTYRKRIDSFVKRQIEDMDDHR-PFFTYWLTFVHSLVTILAVCIY RHDF1_CALJA RHDF1_CALJA EKRPYGLGMVGRLTNRTYRKRIDSFVKRQIEDMDDHR-PFFTYWLTFVHSLVTILAVCIY RHDF1_CALMO RHDF1_CALMO EKRPYGLGMVGRLTNRTYRKRIDSFVKRQIEDMDDHR-PFFTYWLTFVHSLVTVLAVCIY B2KHV7_RHIFE B2KHV7_RHIFE EKRPYGLGMVGRLTNRTYRKRIDSYVKRQIEDMDDHR-PFFTYWLTFVHSLVTILAVCIY RHDF1_MOUSE RHDF1_MOUSE EKRPYGLGMVGRLTNRTYRKRIDSYVKRQIEDMDDHR-PFFTYWLTFVHSLVTILAVCIY RHDF1_RAT RHDF1_RAT EKRPYGLGMVGRLTNRTYRKRIDSYVKRQIEDMDDHR-PFFTYWLTFVHSLVTILAVCIY RHDF1_BOVIN RHDF1_BOVIN EKRPYGLGMVGRLTNRTYRKRIDSYVKRQIEDMDDHR-PFFTYWLTFVHSLVTILAVCIY B8K128_RABIT B8K128_RABIT EKRPYGLGMVGRLTNRTYRKRIDSYVRRQIEDMDDHR-PFFTYWLTFVHSLVTILAVCIY RHDF1_DANRE RHDF1_DANRE EKRPYGLGMVGKLTNRTYRKRIDSYVKKQIEDMDDHR-PFFTYWITFVHILITILAVCIY Q4RHC6_TETNG Q4RHC6_TETNG EKRPYGLGMVGKLTNRTYRKRIDSYVKRQIEDMDDHRQPFFTYWITFVHLLITILAVCIY Q8UV20_9PERC Q8UV20_9PERC EKRPYGLGMVGKLTNRTYRKRIDSYVKRQIEDMDDHR-PFFTYWITFVHLLITILAVCIY RHDF2_XENTR RHDF2_XENTR KKRLYGLGVVGSWLNRTYRRSISSTVQSQLEHFNSHR-PYFAYWITFVHILITILAIATY Q6ZWP8_HUMAN Q6ZWP8_HUMAN KKRHYGLGVVGNWLNRSYRRSISSTVQRQLESFDSHR-PYFTYWLTFVHVIITLLVICTY RHDF2_MOUSE RHDF2_MOUSE KKRHYGLGVVGNWLNRSYRRSISSTVQRQLESFDSHR-PYFTYWLTFVHIIITLLVICTY RHDF2_CANFA RHDF2_CANFA KKRHYGLGVVGNWLNRSYRRSISSTVQRQLESFDSHR-PYFTYWLTFVHIIITLLVICTY B7Z8H4_HUMAN B7Z8H4_HUMAN KKRHYGLGVVGNWLNRSYRRSISSTVQRQLESFDSHR-PYFTYWLTFVHVIITLLVICTY RHDF2_HUMAN RHDF2_HUMAN KKRHYGLGVVGNWLNRSYRRSISSTVQRQLESFDSHR-PYFTYWLTFVHVIITLLVICTY MATCH :** ****:** **:**: *.* *: *:* ::.** *:*:**:**** ::*:*.: * CONSENSUS ?KR?YGLG?VG???NR?YR??I?S?V?RQ?E??D?HR?P?FTYW?TFVH???T?L??C?Y

Q4S4E9_TETNG Q4S4E9_TETNG GIAPIGFSQHETVNSVLRNKGVYENVKFVQQQNFWVGPSSEALIHLGAKFSPCMRRDEEI B4E3N5_HUMAN B4E3N5_HUMAN GIAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSV------------------- B4E3Q0_HUMAN B4E3Q0_HUMAN GIAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSV------------------- B3EX26_SORAR B3EX26_SORAR GIAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQV B3KPT2_HUMAN B3KPT2_HUMAN GIAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQV RHDF1_HUMAN RHDF1_HUMAN GIAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQV RHDF1_PAPAN RHDF1_PAPAN GIAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQV RHDF1_CALJA RHDF1_CALJA GIAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQV RHDF1_CALMO RHDF1_CALMO GIAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQV B2KHV7_RHIFE B2KHV7_RHIFE GIAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQV RHDF1_MOUSE RHDF1_MOUSE GIAPVGFSQHETVDSVLRKRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQV RHDF1_RAT RHDF1_RAT GIAPVGFSQHETVDSVLRKRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQV RHDF1_BOVIN RHDF1_BOVIN GVAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQV B8K128_RABIT B8K128_RABIT GIAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQV RHDF1_DANRE RHDF1_DANRE GIAPVGFSQHETVDSVLRNKGVYENVKFVQQENFWIGPSSEALIHLGAKFSPCMRRDNQV Q4RHC6_TETNG Q4RHC6_TETNG GIAPVGFSQHETVDSVLRNKGVYENVKFVQQENFWIGPSSESLIHLGAKFSPCMRQDQQV Q8UV20_9PERC Q8UV20_9PERC GIAPVGFSQHEAVDSVLRNKGVYENVKFVQQQNFWIGPSSESLIHLGAKFSPCMRQDKQV RHDF2_XENTR RHDF2_XENTR GIAPIGFAQHTTSELVLRNKGVYESVKYIQQENFWIGPSSIALIHLGAKFSPCIRYDEQI Q6ZWP8_HUMAN Q6ZWP8_HUMAN GIAPVGFAQHVTTQLVLRNKGVYESVKYIQQENFWVGPSSIDLIHLGAKFSPCIRKDGQI RHDF2_MOUSE RHDF2_MOUSE GIAPVGFAQHVTTQLVLKNRGVYESVKYIQQENFWIGPSSIDLIHLGAKFSPCIRKDQQI RHDF2_CANFA RHDF2_CANFA GIAPVGFAQHVTTQLVLRNKGVYESVKYIQQENFWIGPSSIDLIHLGAKFSPCIRKDQQI B7Z8H4_HUMAN B7Z8H4_HUMAN GIAPVGFAQHVTTQLVLRNKGVYESVKYIQQENFWVGPSS-------------------- RHDF2_HUMAN RHDF2_HUMAN GIAPVGFAQHVTTQLVLRNKGVYESVKYIQQENFWVGPSSIDLIHLGAKFSPCIRKDGQI MATCH *:**:**:** : : **:::****.**::**:***:**** CONSENSUS GIAPVGF?QH?T???VLRN?GVYE?VKY?QQENFWIGPSS??LIHLGAKFSPC?R?D?Q?

Q4S4E9_TETNG Q4S4E9_TETNG HKLMQEKRAEERESGCCVRNDRSGCLQTLQEECSSTLAVWVKWPHHPSAP---FLHGSLR B4E3N5_HUMAN B4E3N5_HUMAN ---------------------RTG------------------------------------ B4E3Q0_HUMAN B4E3Q0_HUMAN ---------------------RTG------------------------------------ B3EX26_SORAR B3EX26_SORAR HSFVRAAREREKHSACCVRNDRSGCVQTSEEECSSTLAVWVRWPAHPSAP---ELAGHKR B3KPT2_HUMAN B3KPT2_HUMAN HSFIRSAREREKHSACCVRNDRSGCVQTSEEECS------VRFPARDSRL---RLPGVR- RHDF1_HUMAN RHDF1_HUMAN HSFIRSAREREKHSACCVRNDRSGCVQTSEEECSSTLAVWVKWPIHPSAP---ELAGHKR RHDF1_PAPAN RHDF1_PAPAN HSFIRSAREREKHSACCVRNDRSGCVQTSEEECSSTLAVWVKWPIHPSAP---ELAGHKR RHDF1_CALJA RHDF1_CALJA HSFIRAAREREKHSACCVRNDRSGCVQTSEEECSSTLAVWVKWPVHPSAP---ELAGHKR RHDF1_CALMO RHDF1_CALMO HSFIRAAREREKHSACCVRNDRSGCVQTSEEECSSTLAVWVKWPVHPSAP---ELAGHKR B2KHV7_RHIFE B2KHV7_RHIFE HSFIRAAREREKHSACCVRNDRSGCVQTSEEECSSTLAVWVKWPFHPSAP---DLAGQKR RHDF1_MOUSE RHDF1_MOUSE HSFILAAREREKHSACCVRNDRSGCVQTSKEECSSTLAVWVKWPVHPSAP---DLAGNKR RHDF1_RAT RHDF1_RAT HNFILAAREREKHSACCVRNDRSGCVQTSKEECSSTLAVWVKWPVHPSAP---DLAGNKR RHDF1_BOVIN RHDF1_BOVIN HSFIHAAREREKHSACCVRNDRSGCVQTSEEECSSTLAVWVKWPLHPSAP---DLAGQKR B8K128_RABIT B8K128_RABIT HSFIRAAREREKHSACCVRNDRSGCVQTSEEECSSTLAVWVKWPIHPSAP---DLAGQKR RHDF1_DANRE RHDF1_DANRE HELIKKKQELERNSACCVRNDRSGCLQTSEEECSSTLAVWVKWPQHPSVP---QLDGVAR Q4RHC6_TETNG Q4RHC6_TETNG HDLIREKRAIERNSACCVRNDRSGCVQTSEEECSSTLAVWVKWPRHSSTP---QLNGKDR Q8UV20_9PERC Q8UV20_9PERC HELIREKRAVERNSACCVRNDRSGCVQTSEEECSSTLAVWVKWPRHSSAP---QLNGKDR RHDF2_XENTR RHDF2_XENTR KNLIEKQHGLERESGCCIQNDKSGCVQTHRKDCSETLATFIKWPEHDAPVLD-EVTGMKR Q6ZWP8_HUMAN Q6ZWP8_HUMAN EQLVLRERDLERDSGCCVQNDHSGCIQTQRKDCSETLATFVKWQDDTGPPMDKSDLGQKR RHDF2_MOUSE RHDF2_MOUSE EQLVRRERDIERTSGCCVQNDRSGCIQTLKKDCSETLATFVKWQNDTGPS-DKSDLSQKQ RHDF2_CANFA RHDF2_CANFA EQLVLRERDLERDSGCCVQNDHSGCIQTQRKDCSETLATFVKWQDDTGPPMDKSDLGQKR B7Z8H4_HUMAN B7Z8H4_HUMAN -----------------VRAQAGGHHLSQESLC--------------------------- RHDF2_HUMAN RHDF2_HUMAN EQLVLRERDLERDSGCCVQNDHSGCIQTQRKDCSETLATFVKWQDDTGPPMDKSDLGQKR MATCH * CONSENSUS ??????????E??S?CCV?ND?SGC?QT????CS?TLA??V?W?????????????G???

Q4S4E9_TETNG Q4S4E9_TETNG QHGAVCHQDPRICVEPASVTPHEWPDDITEWPICTKYDSGNHTNLPHVDCTITGRPCCMG B4E3N5_HUMAN B4E3N5_HUMAN -----------LGAGPAGAGP-----------------GGARRGQEAPDC---GRSSPSP B4E3Q0_HUMAN B4E3Q0_HUMAN -----------LGAGPAGAGP-----------------GGARRGQEAPDC---GRSSPSP B3EX26_SORAR B3EX26_SORAR QFGSVCHQDPRVCDEPSSEDPHEWPDDITKWPICTKSSAGNHTNHPHMDCVITGRPCCIG B3KPT2_HUMAN B3KPT2_HUMAN ------------------------------------------------------------ RHDF1_HUMAN RHDF1_HUMAN QFGSVCHQDPRVCDEPSSEDPHEWPEDITKWPICTKNSAGNHTNHPHMDCVITGRPCCIG RHDF1_PAPAN RHDF1_PAPAN QFGSVCHQDPRVCDEPSSEDPHEWPEDITKWPICTKNSAGNHTNHPHMDCVITGRPCCIG RHDF1_CALJA RHDF1_CALJA QFGSVCHQDPRVCDEPSSEDPHEWPEDITRWPICTKNSAGNHTNHPHMDCVITGRPCCIG RHDF1_CALMO RHDF1_CALMO QFGSVCHQDPRVCDEPSSEDPHEWPEDITRWPICTKNSAGNHTNHPHMDCVITGRPCCIG B2KHV7_RHIFE B2KHV7_RHIFE QFGSVCHQDPRVCDEPSSEDPHEWPDDITKWPICTKNSAGNHTNHPHMDCAITGRPCCIG RHDF1_MOUSE RHDF1_MOUSE QFGSVCHQDPRVCDEPSSEDPHEWPEDITKWPICTKSSAGNHTNHPHMDCVITGRPCCIG RHDF1_RAT RHDF1_RAT QFGSVCHQDPRVCDEPSSEDPHEWPEDITKWPICTKNSAGNHTNHPHMDCVITGRPCCIG RHDF1_BOVIN RHDF1_BOVIN RYGSVCHQDPRVCDEPSSEDPHEWPDDITKWPICTKSSAGNHTNHPHMDCVITGRPCCIG B8K128_RABIT B8K128_RABIT QFGSVCHQDPRVCDEPSSEDPHEWPEDITKWPICTKSSAGNHTNHPHMDCVLTGRPCCIG RHDF1_DANRE RHDF1_DANRE QHGSVCHQDPRTCTEPASVSPHEWPDDITKWPICTKYNSGNHTNLPHIDCTITGRPCCIG Q4RHC6_TETNG Q4RHC6_TETNG QHGSVCHQDPRICLEPASVSPHEWPDDITKWPICTKYNTGNHTNLPHIDCTITGRPCCIG Q8UV20_9PERC Q8UV20_9PERC QYGSVCHQDPRTCLEPASGLPHEWPDDITKWPICTKYNTGNHTNLPHIDCTIMGRPCCIG RHDF2_XENTR RHDF2_XENTR TSGAVCHQDPRTCEEPASIQPHVWADDITKWPICTYQAMNNHTGIRHMDCEIKGRPCCIG Q6ZWP8_HUMAN Q6ZWP8_HUMAN TSGAVCHQDPRTCEEPASSGAHIWPDDITKWPICTEQARSNHTGFLHMDCEIKGRPCCIG RHDF2_MOUSE RHDF2_MOUSE PSAVVCHQDPRTCEEPASSGAHIWPDDITKWPICTEQAQSNHTGLLHIDCKIKGRPCCIG RHDF2_CANFA RHDF2_CANFA TSGAVCHQDPRTCEEPASSGAHIWPDDITKWPICTEQAKSNRTGFLHMDCQIKGRPCCIS B7Z8H4_HUMAN B7Z8H4_HUMAN ------------------------------------------------------------ RHDF2_HUMAN RHDF2_HUMAN TSGAVCHQDPRTCEEPASSGAHIWPDDITKWPICTEQARSNHTGFLHMDCEIKGRPCCIG MATCH CONSENSUS ????VCHQDPR?C?EP?S???H?W??DIT?WPICT?????N?T???H?DC???GRPCC??

Q4S4E9_TETNG Q4S4E9_TETNG TKGRCEITSREYCEFMHGYFHEEATLCSQVACMDDICGLLPFLNPEVPDQFSRLWLSLFL B4E3N5_HUMAN B4E3N5_HUMAN AGG-----------------------------------------PHPP------------ B4E3Q0_HUMAN B4E3Q0_HUMAN AGG-----------------------------------------PHPP------------ B3EX26_SORAR B3EX26_SORAR TKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFL B3KPT2_HUMAN B3KPT2_HUMAN ------------------------------------------------------------ RHDF1_HUMAN RHDF1_HUMAN TKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFL RHDF1_PAPAN RHDF1_PAPAN TKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFL RHDF1_CALJA RHDF1_CALJA TKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFL RHDF1_CALMO RHDF1_CALMO TKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFL B2KHV7_RHIFE B2KHV7_RHIFE TKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFL RHDF1_MOUSE RHDF1_MOUSE TKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFL RHDF1_RAT RHDF1_RAT TKGRCEITSREYCDFMKGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFL RHDF1_BOVIN RHDF1_BOVIN TKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFL B8K128_RABIT B8K128_RABIT TKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFL RHDF1_DANRE RHDF1_DANRE TKGRCEITSREYCDFMKGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFL Q4RHC6_TETNG Q4RHC6_TETNG TKGRCEITSREYCDFMKGYFHEEATLCSQVHCMDDVCGLLPFLNPEIPDQFYRLWLSLFL Q8UV20_9PERC Q8UV20_9PERC TKGRCEITSREYCDFMKGYFHEEATLCSQVHCMDDVCGLLPFLNPEIPDQFYRLWLSLFL RHDF2_XENTR RHDF2_XENTR TKGSCEITTREYCTFMHGYFHEEATLCSQVHCLDEVCGLLPFLNPEYPDQFYRLWLSLFL Q6ZWP8_HUMAN Q6ZWP8_HUMAN TKGSCEITTREYCEFMHGYFHEEATLCSQVHCLDKVCGLLPFLNPEVPDQFYRLWLSLFL RHDF2_MOUSE RHDF2_MOUSE TKGSCEITTREYCEFMHGYFHEDATLCSQVHCLDKVCGLLPFLNPEVPDQFYRIWLSLFL RHDF2_CANFA RHDF2_CANFA TKGSCEITTREYCEFMHGYFHEEATLCSQVHCLDKVCGLLPFLNPEVPDQFYRLWLSLFL B7Z8H4_HUMAN B7Z8H4_HUMAN ------------------------------------------------------------ RHDF2_HUMAN RHDF2_HUMAN TKGSCEITTREYCEFMHGYFHEEATLCSQVHCLDKVCGLLPFLNPEVPDQFYRLWLSLFL MATCH CONSENSUS TKG?CEIT?REYC?FM?GYFHE?ATLCSQV?C?D??CGLLPFLNPE?PDQF?R?WLSLFL

Q4S4E9_TETNG Q4S4E9_TETNG HAGVLHCLVSVVFQMTVLRDIEKLVGWLRVSIIYMLSGITGNLASAIFLPYRAEVGPAGS B4E3N5_HUMAN B4E3N5_HUMAN ----------------------------------------GRQVFALHAP-----GPAGA B4E3Q0_HUMAN B4E3Q0_HUMAN ----------------------------------------GRQVFALHAP-----GPAGA B3EX26_SORAR B3EX26_SORAR HAGVLHCLVSVCFQMTVLRDLEKLAGWHRIAIIYLLSGITGNLASAIFLPYRAEVGPAGS B3KPT2_HUMAN B3KPT2_HUMAN ------------------------------------------------------------ RHDF1_HUMAN RHDF1_HUMAN HAGILHCLVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGS RHDF1_PAPAN RHDF1_PAPAN HAGILHCLVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGS RHDF1_CALJA RHDF1_CALJA HAGILHCLVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGS RHDF1_CALMO RHDF1_CALMO HAGILHCLVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGS B2KHV7_RHIFE B2KHV7_RHIFE HAGILHCLVSVCFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGS RHDF1_MOUSE RHDF1_MOUSE HAGILHCLVSVCFQMTVLRDLEKLAGWHRIAIIYLLSGITGNLASAIFLPYRAEVGPAGS RHDF1_RAT RHDF1_RAT HAGILHCLVSVCFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGS RHDF1_BOVIN RHDF1_BOVIN HAGVLHCLVSVCFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGS B8K128_RABIT B8K128_RABIT HAGILHCLVSVCFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGS RHDF1_DANRE RHDF1_DANRE HAGILHCLVSVCFQMTILRDLEKLAGWLRISIIYILSGITGNLASAIFLPYRAEVGPAGS Q4RHC6_TETNG Q4RHC6_TETNG HAGILHCLVSVAFQMTILRDLEKLAGWLRISIIYIISGITGNLASAIFLPYRAEVGPAGS Q8UV20_9PERC Q8UV20_9PERC HAGILHCLVSVAFQMTILRDLEKLAGWLRISIIYIISGITGNLASAIFLPYRAEVGPAGS RHDF2_XENTR RHDF2_XENTR HAGVIHCCVSVVFQMTVLRDLEKLAGWLRISIIYILSGITGNLASALFLPYRAEVGPAGS Q6ZWP8_HUMAN Q6ZWP8_HUMAN HAGVVHCLVSVVFQMTILRDLEKLAGWHRIAIIFILSGITGNLASAIFLPYRAEV----- RHDF2_MOUSE RHDF2_MOUSE HAGIVHCLVSVVFQMTILRDLEKLAGWHRISIIFILSGITGNLASAIFLPYRAEVGPAGS RHDF2_CANFA RHDF2_CANFA HAGVVHCLVSVVFQMTILRDLEKLAGWHRIAIIFILSGITGNLASAIFLPYRAEVGPAGS B7Z8H4_HUMAN B7Z8H4_HUMAN ------------------------------------------------------------ RHDF2_HUMAN RHDF2_HUMAN HAGVVHCLVSVVFQMTILRDLEKLAGWHRIAIIFILSGITGNLASAIFLPYRAEVGPAGS MATCH CONSENSUS HAG??HC?VS??FQMT?LRD?EKL?GW?R??II???SG?TGNLASA?FLPYRAEVGPAG?

Q4S4E9_TETNG Q4S4E9_TETNG QFGILACLFVELFQSWPILERPWRAFAKLLAISTFFFSFGLLPWIDNFAHICGFVSGFFL B4E3N5_HUMAN B4E3N5_HUMAN QLHSLGARAREALRLLRAQRQ-----------------------VGLRADLGGGVLGAFP B4E3Q0_HUMAN B4E3Q0_HUMAN QLHSLGARAREALRLLRAQRQ-----------------------VGLRADLGGGVLGAFP B3EX26_SORAR B3EX26_SORAR QFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFL B3KPT2_HUMAN B3KPT2_HUMAN ------------------------------------------------------------ RHDF1_HUMAN RHDF1_HUMAN QFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFL RHDF1_PAPAN RHDF1_PAPAN QFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFL RHDF1_CALJA RHDF1_CALJA QFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFL RHDF1_CALMO RHDF1_CALMO QFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFL B2KHV7_RHIFE B2KHV7_RHIFE QFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFVSGLFL RHDF1_MOUSE RHDF1_MOUSE QFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFAFGLLPWIDNFAHISGFVSGLFL RHDF1_RAT RHDF1_RAT QFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFAFGLLPWIDNFAHISGFVSGLFL RHDF1_BOVIN RHDF1_BOVIN QFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFL B8K128_RABIT B8K128_RABIT QFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHVSGFVSGLFL RHDF1_DANRE RHDF1_DANRE QFGILACLFVELIQSWQILAQPWRAFTKLLCVVLFLFAFGLLPWIDNFAHISGFISGFFL Q4RHC6_TETNG Q4RHC6_TETNG QFGILACLFVELFQSWQILAQPWRAFIKLLCVVLFLFAFGLLPWIDNFAHICGFISGFFL Q8UV20_9PERC Q8UV20_9PERC QFGILACLFVELFQSWQILAQPWRAFTKLLCVVLFLFAFGLLPWIDNFAHISGFISGFFL RHDF2_XENTR RHDF2_XENTR QFGLLACLFVELFQSWQILAKPWKAFLKLLGIVLFLFLFGLLPWIDNIAHIFGFLSGLLL Q6ZWP8_HUMAN Q6ZWP8_HUMAN --------------------RMWR--------------MGPLPHIGG------------- RHDF2_MOUSE RHDF2_MOUSE QFGLLACLFVELFQSWQLLERPWKAFFNLSAIVLFLFICGLLPWIDNIAHIFGFLSGMLL RHDF2_CANFA RHDF2_CANFA QFGLLACLFVELFQSWQLLERPWKAFLNLSAIVLFLFICGLLPWIDNIAHIFGFLSGLLL B7Z8H4_HUMAN B7Z8H4_HUMAN ------------------------------------------------------------ RHDF2_HUMAN RHDF2_HUMAN QFGLLACLFVELFQSWPLLERPWKAFLNLSAIVLFLFICGLLPWIDNIAHIFGFLSGLLL MATCH CONSENSUS Q???L?????E???????????W????????????????G?LP?I???A???G???G???

Q4S4E9_TETNG Q4S4E9_TETNG SFAFLPYISFRRSDMYLKRLQICVFLLVFVGLLSALLVLFYVYPVKCEWCEYLTCIPITD B4E3N5_HUMAN B4E3N5_HUMAN RLGLPPSSA---------RCSL-------------------------------------- B4E3Q0_HUMAN B4E3Q0_HUMAN RPGLPPSSA---------RCSL-------------------------------------- B3EX26_SORAR B3EX26_SORAR SFAFLPYISFGKFDLYRKRCQIIVFQVVFLGLLAGLVVLFYFYPVRCEWCEFLTCIPFTD B3KPT2_HUMAN B3KPT2_HUMAN ------------------------------------------------------------ RHDF1_HUMAN RHDF1_HUMAN SFAFLPYISFGKFDLYRKRCQIIIFQVVFLGLLAGLVVLFYVYPVRCEWCEFLTCIPFTD RHDF1_PAPAN RHDF1_PAPAN SFAFLPYISFGKFDLYRKRCQIIIFQVVFLGLLAGLVVLFYFYPVRCEWCEFLTCIPFTD RHDF1_CALJA RHDF1_CALJA SFAFLPYISFGKFDLYRKRCQIIVFQVVFLGLLAGLVVLFYVYPVRCEWCEFLTCIPFTD RHDF1_CALMO RHDF1_CALMO SFAFLPYISFGKFDLYRKRCQIIVFQVVFLGLLAGLVVLFYFYPVRCEWCEFLTCIPFTD B2KHV7_RHIFE B2KHV7_RHIFE SFAFLPYVSFGRFDLYRKRCQILIFQAVFLGLLAGLVVLFYFYPVRCEWCEFLTCIPFTD RHDF1_MOUSE RHDF1_MOUSE SFAFLPYISFGKFDLYRKRCQIIIFQVVFLGLLAGLVVLFYFYPVRCEWCEFLTCIPFTD RHDF1_RAT RHDF1_RAT SFAFLPYISFGKFDLYRKRCQIIIFQAVFLGLLAGLVVLFYFYPVRCEWCEFLTCIPFTD RHDF1_BOVIN RHDF1_BOVIN SFAFLPYISFGKFDLYRKRCQIIVFQLVFLGLLAGLVVLFYFYPVRCEWCEFLTCIPFTD B8K128_RABIT B8K128_RABIT SFAFLPYISFGKFDLYRKRCQIIVFQLVFLGLLAGLVVLFYFYPVRCEWCEFLTCIPFTD RHDF1_DANRE RHDF1_DANRE SFAFLPYISFGRLDMYRKRCQIIIFLVVFLGLFAGLVVLFYVHPIKCEWCELLTCIPFTD Q4RHC6_TETNG Q4RHC6_TETNG SFAFLPYISFGRMDLCRKRCQIIVFLLVFVGLFSGLVVLFYVYPIKCEWCELLTCIPFTD Q8UV20_9PERC Q8UV20_9PERC SFAFLPYISFGRMDLYRKRCQIIVFLLVFVGLFSGLAVLFYVYPIKCDWCELLTCIPFTD RHDF2_XENTR RHDF2_XENTR SFSFLPYITFGTADKFRKRAMIIISLLVFVGLFASLVIWLYVYPINWAWIEYLTCLPFTN Q6ZWP8_HUMAN Q6ZWP8_HUMAN ----QPCCSYSTHLGSARGTRCPSCTGLHSGGTANLGAY---------WLVS-------- RHDF2_MOUSE RHDF2_MOUSE AFAFLPYITFGTSDKYRKRALILVSLLVFAGLFASLVLWLYIYPINWPWIEYLTCFPFTS RHDF2_CANFA RHDF2_CANFA AFAFLPYITFGTSDKYRKRALILVSLLVFAGLFASLVIWLYVYPINWPWIEYLTCFPFTS B7Z8H4_HUMAN B7Z8H4_HUMAN -------------------------------------------PVTPSWAD--------- RHDF2_HUMAN RHDF2_HUMAN AFAFLPYITFGTSDKYRKRALILVSLLAFAGLFAALVLWLYIYPINWPWIEHLTCFPFTS MATCH CONSENSUS ?????P????????????R???????????G????L???????P????W???????????

Q4S4E9_TETNG Q4S4E9_TETNG MFCETYDLNAHLL B4E3N5_HUMAN B4E3N5_HUMAN -FRPQIDPAE--- B4E3Q0_HUMAN B4E3Q0_HUMAN -FRPQIDSAE--- B3EX26_SORAR B3EX26_SORAR KFCEKYELDAQLH B3KPT2_HUMAN B3KPT2_HUMAN --------SSDLR RHDF1_HUMAN RHDF1_HUMAN KFCEKYELDAQLH RHDF1_PAPAN RHDF1_PAPAN KFCEKYELDAQLH RHDF1_CALJA RHDF1_CALJA KFCEKYELDAQLH RHDF1_CALMO RHDF1_CALMO KFCEKYELDAQLH B2KHV7_RHIFE B2KHV7_RHIFE KFCEKYELDAQLH RHDF1_MOUSE RHDF1_MOUSE KFCEKYELDAQLH RHDF1_RAT RHDF1_RAT KFCEKYELDAQLH RHDF1_BOVIN RHDF1_BOVIN KFCEKYELDAQLH B8K128_RABIT B8K128_RABIT KFCEKYELDAQLH RHDF1_DANRE RHDF1_DANRE KFCEKYDLNAHLH Q4RHC6_TETNG Q4RHC6_TETNG KFCEKYDLNAHLH Q8UV20_9PERC Q8UV20_9PERC KFCEKYDLNAHLH RHDF2_XENTR RHDF2_XENTR KFCEKYDIDQVLH Q6ZWP8_HUMAN Q6ZWP8_HUMAN ------------- RHDF2_MOUSE RHDF2_MOUSE RFCEKYELDQVLH RHDF2_CANFA RHDF2_CANFA RFCEKYELDQVLH B7Z8H4_HUMAN B7Z8H4_HUMAN ------------- RHDF2_HUMAN RHDF2_HUMAN RFCEKYELDQVLH MATCH CONSENSUS ?F?????????L?


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