Alignment of the gene Family HBG065810 of HOVERGEN

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Threshold: 50% 80% 100%
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Isoforms are ON
Q4T471_TETNG Q4T471_TETNG ------------------------------------------------------------ Q4SAZ0_TETNG Q4SAZ0_TETNG ------------------------------------------------------------ Q719M0_BRAFL Q719M0_BRAFL -----------------------------------MATQPSPPLPSPGHG--------HG B3DJL7_DANRE B3DJL7_DANRE --------------------------------MTTMAVPATLPVHSGTSA---VSG--KL Q8QHJ2_DANRE Q8QHJ2_DANRE -----------------------------------MAVPATLPVHSGTSA---VSG--KL B3DGP5_DANRE B3DGP5_DANRE -----------------------------------MAVSATPPVLSPTST--PGGA--SL Q8QHJ3_DANRE Q8QHJ3_DANRE -----------------------------------MAVSATPPVLSPTST--PGGA--SL B1AUM0_MOUSE B1AUM0_MOUSE ------------------------------------MAVSAPPVISATSSSAGVPG--GL B1AU60_MOUSE B1AU60_MOUSE ------------------------------------------------------------ B1AU58_MOUSE B1AU58_MOUSE ------------------------------------MAVSAPPVISATSSSAGVPG--GL DACH2_MOUSE DACH2_MOUSE ------------------------------------MAVSAPPVISATSSSAGVPG--GL B1AU59_MOUSE B1AU59_MOUSE ------------------------------------------------------------ B1AXA6_MOUSE B1AXA6_MOUSE ------------------------------------------------------------ Q9BGY9_MACFA Q9BGY9_MACFA ------------------------------------------------------------ A8K3I1_HUMAN A8K3I1_HUMAN ------------------------------------MAVSASPVISATSSGAGVPG--GL B1AJV3_HUMAN B1AJV3_HUMAN ------------------------------------MAVSASPVISATSSGAGVPG--GL Q1RMF5_HUMAN Q1RMF5_HUMAN -----------------------------------------MPEFRSVAQ---------- B4DQG3_HUMAN B4DQG3_HUMAN ------------------------------------------------------------ A8MW17_HUMAN A8MW17_HUMAN ------------------------------------------------------------ B1AJV4_HUMAN B1AJV4_HUMAN ------------------------------------MAVSASPVISATSSGAGVPG--GL DACH2_HUMAN DACH2_HUMAN ------------------------------------MAVSASPVISATSSGAGVPG--GL B4DGA6_HUMAN B4DGA6_HUMAN ------------------------------------------------------------ B4DIK6_HUMAN B4DIK6_HUMAN ------------------------------------------------------------ Q9PTH2_CHICK Q9PTH2_CHICK ------------------------------------MAVSAPPVIAATSSGGGAGGSAGL Q5PQ18_XENLA Q5PQ18_XENLA ------------------------------------MAVSAPPVINATST--PASG--GL A4QNQ3_XENTR A4QNQ3_XENTR ------------------------------------MAVSAPPVINATST--PASG--GL A8E4U6_XENTR A8E4U6_XENTR ------------------------------------MAVSAPPVINATST--PASG--GL Q4RWD1_TETNG Q4RWD1_TETNG -----------------------------------MNANGSRPGRPPKRTQSVTSP---- Q1JPW1_DANRE Q1JPW1_DANRE ------------MAHAPPMSISA------------VVNSSTPATLSPSPSVTPAGP--SL Q8QHJ1_DANRE Q8QHJ1_DANRE ------------MAHAPPMSISA------------VVNSSTPATLSPSPSVAPAGP--SL B3DH35_DANRE B3DH35_DANRE ------------MAHAPPMSISA------------VVNSSTPATLSPSPSVAPAGP--SL Q0PNF7_XENTR Q0PNF7_XENTR AVPAALIPPTQLVTPQAAISSSASSSSSSTNSSS-SATNSPSPSIAPSSS----GQ--SL Q70Q44_XENLA Q70Q44_XENLA AVPAALIPPTQLVTPQAAISSSASSSSSSSANSTSSANNSPSPSVAPSSS----GQ--SL Q70Q63_XENLA Q70Q63_XENLA AVPAALIPPTQLVTPQAAISSSASSSSSSSANSTSSANNSPSPSVAPSSS----GQ--SL B7ZRN2_XENLA B7ZRN2_XENLA AVPAALIPPTQLVTPQAAISSSASSSSSSSANSTSSANNSPSPSVAPSSS----GQ--SL Q0PNF8_XENLA Q0PNF8_XENLA AVPAALIPPTQLVTPQAAISSSASSSSSSSANSTSSANNSPSPSVAPSSS----GQ--SL Q8QHJ0_CHICK Q8QHJ0_CHICK ------------------------------------ATSSPAPAIAPPPP--ASGT--NL Q3UTV2_MOUSE Q3UTV2_MOUSE AVPAALIPPTQLVPPQPPISTSASSSGTTTSTS--SATSSPAPSIGPPAS---SGP--TL DACH1_MOUSE DACH1_MOUSE AVPAALIPPTQLVPPQPPISTSASSSGTTTSTS--SATSSPAPSIGPPAS---SGP--TL Q68G54_MOUSE Q68G54_MOUSE ---AALIPPTQLVPPQPPISTSASSSGTTTSTS--SATSSPAPSIGPPAS---SGP--TL A6NJF5_HUMAN A6NJF5_HUMAN AVPAALIPPTQLVPPQPPISTSASSSGTTTSTS--SATSSPAPSIGPPAS---SGP--TL DACH1_HUMAN DACH1_HUMAN AVPAALIPPTQLVPPQPPISTSASSSGTTTSTS--SATSSPAPSIGPPAS---SGP--TL A1L2G2_DANRE A1L2G2_DANRE AVPAALIPPSALVHPCPISTSSSASSASSSSCSA-TAASSSSPSATSASPSQSATQ--NL Q8UUQ4_ORYLA Q8UUQ4_ORYLA -----------------------------------MHNGTPLKSGGAPVT----GG---- MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4T471_TETNG Q4T471_TETNG ------------------------------------------------------------ Q4SAZ0_TETNG Q4SAZ0_TETNG ------------------------------------------------------------ Q719M0_BRAFL Q719M0_BRAFL LSPPPVASPLGL------------------------------------------------ B3DJL7_DANRE B3DJL7_DANRE FRTEPFFSSPAEAPRIIN------------------------------------------ Q8QHJ2_DANRE Q8QHJ2_DANRE FRTEPFFSSPDESPRIIN------------------------------------------ B3DGP5_DANRE B3DGP5_DANRE FRPDSLYSSPAESPRLTSSMINSFITGGGSTNG--------------------------- Q8QHJ3_DANRE Q8QHJ3_DANRE FRPDSLYSNPAESPRLTSSMINSFITGGGSTNG--------------------------- B1AUM0_MOUSE B1AUM0_MOUSE FRAEPLYSSPGEPPRLTPNMINSFMANNHNG----------------------------- B1AU60_MOUSE B1AU60_MOUSE ------------------------------------------------------------ B1AU58_MOUSE B1AU58_MOUSE FRAEPLYSSPGEPPRLTPNMINSFMANNHNG----------------------------- DACH2_MOUSE DACH2_MOUSE FRAEPLYSSPGEPPRLTPNMINSFMANNHNG----------------------------- B1AU59_MOUSE B1AU59_MOUSE ------------------------------------------------------------ B1AXA6_MOUSE B1AXA6_MOUSE ------------------------------------------------------------ Q9BGY9_MACFA Q9BGY9_MACFA ------------------------------------------------------------ A8K3I1_HUMAN A8K3I1_HUMAN FRAEPLYSTPREPPRLTPNMINSFVVNNHS------------------------------ B1AJV3_HUMAN B1AJV3_HUMAN FRAEPLYSTPREPPRLTPNMINSFVVNNHS------------------------------ Q1RMF5_HUMAN Q1RMF5_HUMAN ------------------------------------------------------------ B4DQG3_HUMAN B4DQG3_HUMAN ------------------------------------------------------------ A8MW17_HUMAN A8MW17_HUMAN ------------------------------------------------------------ B1AJV4_HUMAN B1AJV4_HUMAN FRAEPLYSTPREPPRLTPNMINSFVVNNHS------------------------------ DACH2_HUMAN DACH2_HUMAN FRAEPLYSTPREPPRLTPNMINSFVVNNHS------------------------------ B4DGA6_HUMAN B4DGA6_HUMAN ------------------------------------------------------------ B4DIK6_HUMAN B4DIK6_HUMAN ------------------------------------------------------------ Q9PTH2_CHICK Q9PTH2_CHICK FRADPLYSSPAESPRLTNSLVNSFLSAGGGG----------------------------- Q5PQ18_XENLA Q5PQ18_XENLA YSG---SSPAADSPRLG--MLSSFVPSGSS------------------------------ A4QNQ3_XENTR A4QNQ3_XENTR YSS---SSPAAESPRLG--MLSSFVPSGSS------------------------------ A8E4U6_XENTR A8E4U6_XENTR YSS---SSPAAESPRLG--MLSSFVPSGSS------------------------------ Q4RWD1_TETNG Q4RWD1_TETNG -----------ENPHIMPHSV--------------------------------------- Q1JPW1_DANRE Q1JPW1_DANRE FRTELPSSASPGIP---------------------------------------------- Q8QHJ1_DANRE Q8QHJ1_DANRE FRTELLSSASPGIP---------------------------------------------- B3DH35_DANRE B3DH35_DANRE FRTELLSSASPGIP---------------------------------------------- Q0PNF7_XENTR Q0PNF7_XENTR YRPEPTAATPVTPSSLSSPAPNLTASNSSSQGAAGTGGGGSNGILTNCSSSSLSPSLTTT Q70Q44_XENLA Q70Q44_XENLA YRPEPLAATTVTPSSLSGPTPNLTASSGSNSQGSGAAAGTGGVGGGGGGSNGILSNCNSP Q70Q63_XENLA Q70Q63_XENLA YRPEPLAATTVTPSSLSGPTPNLTASSGSNSQGSGAAAGTGGVGGGGGGSNGILSNCNSP B7ZRN2_XENLA B7ZRN2_XENLA YRPEPLAATTVTPSSLSPTPNLTASSGSNSQGSGAAAGTGGVGGGGGGSNGILSNCNSPS Q0PNF8_XENLA Q0PNF8_XENLA YRPEPLAATTVTPSSLSGPTPNLTASSGSNSQGSGAAAGTGGVGGGGGGSNGILSNCNSP Q8QHJ0_CHICK Q8QHJ0_CHICK FRPEPIAAPAAAAATVTSTATTTTTGGSGGGGGSGGGGGSPSLGSGTGGG---------- Q3UTV2_MOUSE Q3UTV2_MOUSE FRPEPIASSASSSAAATVTSPGGGGGGSGGGGGS-------GGNGGGGGSNCNPSLAA-- DACH1_MOUSE DACH1_MOUSE FRPEPIASSASSSAAATVT--SPGGGGGGSGGGGGS-----GGNGGGGGSNCNPSLAA-- Q68G54_MOUSE Q68G54_MOUSE FRPEPIASSASSSAAATVTSPGGGGGGSGGGGGS-------GGNGGGGGSNCNPSLAA-- A6NJF5_HUMAN A6NJF5_HUMAN FRPEPIASAAAAAATVTSTGGGGGGGGGGSGGGGGSSGNGGGGGGGGGGSNCNPNLAAAS DACH1_HUMAN DACH1_HUMAN FRPEPIASAAAAAATVTST--GGGGGGGGSGGGGGSSGNGGGGGGGGGGSNCNPNLAAAS A1L2G2_DANRE A1L2G2_DANRE FRADLISTNCTSSI---------------------------------------------- Q8UUQ4_ORYLA Q8UUQ4_ORYLA ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4T471_TETNG Q4T471_TETNG ------------------------------------------------------------ Q4SAZ0_TETNG Q4SAZ0_TETNG ------------------------------------------------------------ Q719M0_BRAFL Q719M0_BRAFL --------------------------------------------------------FKLD B3DJL7_DANRE B3DJL7_DANRE --------------------------------------------------------SLPS Q8QHJ2_DANRE Q8QHJ2_DANRE --------------------------------------------------------SLPS B3DGP5_DANRE B3DGP5_DANRE --------------------------------------------------------NGPG Q8QHJ3_DANRE Q8QHJ3_DANRE --------------------------------------------------------NGPG B1AUM0_MOUSE B1AUM0_MOUSE --------------------------------------------------------SVLG B1AU60_MOUSE B1AU60_MOUSE ------------------------------------------------------------ B1AU58_MOUSE B1AU58_MOUSE --------------------------------------------------------SVLG DACH2_MOUSE DACH2_MOUSE --------------------------------------------------------SVLG B1AU59_MOUSE B1AU59_MOUSE ------------------------------------------------------------ B1AXA6_MOUSE B1AXA6_MOUSE ------------------------------------------------------------ Q9BGY9_MACFA Q9BGY9_MACFA ------------------------------------------------------------ A8K3I1_HUMAN A8K3I1_HUMAN --------------------------------------------------------NSAG B1AJV3_HUMAN B1AJV3_HUMAN --------------------------------------------------------NSAG Q1RMF5_HUMAN Q1RMF5_HUMAN ------------------------------------------------------------ B4DQG3_HUMAN B4DQG3_HUMAN ------------------------------------------------------------ A8MW17_HUMAN A8MW17_HUMAN ------------------------------------------------------------ B1AJV4_HUMAN B1AJV4_HUMAN --------------------------------------------------------NSAG DACH2_HUMAN DACH2_HUMAN --------------------------------------------------------NSAG B4DGA6_HUMAN B4DGA6_HUMAN ------------------------------------------------------------ B4DIK6_HUMAN B4DIK6_HUMAN ------------------------------------------------------------ Q9PTH2_CHICK Q9PTH2_CHICK --------------------------------------------------------TGAG Q5PQ18_XENLA Q5PQ18_XENLA --------------------------------------------------------PLAG A4QNQ3_XENTR A4QNQ3_XENTR --------------------------------------------------------PLAG A8E4U6_XENTR A8E4U6_XENTR --------------------------------------------------------PLAG Q4RWD1_TETNG Q4RWD1_TETNG --------------------------------------------------------PWPN Q1JPW1_DANRE Q1JPW1_DANRE ------------------------------------------------------IGSLPH Q8QHJ1_DANRE Q8QHJ1_DANRE ------------------------------------------------------IGSLPH B3DH35_DANRE B3DH35_DANRE ------------------------------------------------------IGSLPH Q0PNF7_XENTR Q0PNF7_XENTR NSSSSHHNNSI-------------------IPSTPATSTSTTSTSSNSSSSSAPTSNLPG Q70Q44_XENLA Q70Q44_XENLA STTNSSNSSHHNNNNL--------------IIPGSTSSHIQQHHIPPAAATTLPTSNLPG Q70Q63_XENLA Q70Q63_XENLA STTNSSNSSHHNNNNL--------------IIPGSTSSHIQQHHIPPAAATTLPTSNLPG B7ZRN2_XENLA B7ZRN2_XENLA TTNSSNSSHHNNNN----------------LIIPGSTSATSSSTTSTSSSNNTPTSNLPG Q0PNF8_XENLA Q0PNF8_XENLA STTNSSNSSHHNNNN---------------LIIPGSTSATSSSTTSTSSSNNTPTSNLPG Q8QHJ0_CHICK Q8QHJ0_CHICK -------------------------------------------TSGTSTPNAGAAGSLPG Q3UTV2_MOUSE Q3UTV2_MOUSE ---GSSGGGVSAGGGGASSTPITASTGSSSSSSSSSSSSSSSSSSSSSSSSSSSCGPLPG DACH1_MOUSE DACH1_MOUSE ---GSSGGGVSAGGGGASSTPITASTGSSSSSSSSSSSSSSSSSSSSSSSSSSSCGPLPG Q68G54_MOUSE Q68G54_MOUSE ---GSSGGGVSAGGGGASSTPITASTGSSSSSSSSSSSSSSSSSSSSSSSSSSSCGPLPG A6NJF5_HUMAN A6NJF5_HUMAN NGSGGGGGGISAGGGVASSTPINASTG---SSSSSSSSSSSSSSSSSSSSSSSSCGPLPG DACH1_HUMAN DACH1_HUMAN NGSGGGGGGISAGGGVASSTPINASTG---SSSSSSSSSSSSSSSSSSSSSSSSCGPLPG A1L2G2_DANRE A1L2G2_DANRE --------------------------------------------------------PLAG Q8UUQ4_ORYLA Q8UUQ4_ORYLA -----------------------------------------------------------A MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4T471_TETNG Q4T471_TETNG ------------------------------------------------------------ Q4SAZ0_TETNG Q4SAZ0_TETNG ------------------------------------------------------------ Q719M0_BRAFL Q719M0_BRAFL KPAYSTPPPAENTPANNVCRMIDYRGAKVAAFTVDGREVICLPQAFDLFLKHLVGGLHTV B3DJL7_DANRE B3DJL7_DANRE GG------------TTNECKIVEVHGVKVASFSVDGQELICLPQVFDLFLKHLVGGLHTV Q8QHJ2_DANRE Q8QHJ2_DANRE GG------------TTNECKIVEVHGVKVASFSVDGQELICLPQVFDLFLKHLVGGLHTV B3DGP5_DANRE B3DGP5_DANRE GV------------HNNECKMVEVHGVKVASFTVDGQELICLPQVFDLFLKHLVGGLHTV Q8QHJ3_DANRE Q8QHJ3_DANRE GV------------HNNECKMVEVHGVKVASFTVDGQELICLPQVFDLFLKHLVGGLHTV B1AUM0_MOUSE B1AUM0_MOUSE GGIGGGSGGSSNT-NTNECRMVDMHGVKVASFLMDGQELICLPQVFDLFLKHLVGGLHTV B1AU60_MOUSE B1AU60_MOUSE ------------------------------------------------------------ B1AU58_MOUSE B1AU58_MOUSE GGIGGGSGGSSNT-NTNECRMVDMHGVKVASFLMDGQELICLPQVFDLFLKHLVGGLHTV DACH2_MOUSE DACH2_MOUSE GGIGGGSGGSSNT-NTNECRMVDMHGVKVASFLMDGQELICLPQVFDLFLKHLVGGLHTV B1AU59_MOUSE B1AU59_MOUSE ------------------------------------------------------------ B1AXA6_MOUSE B1AXA6_MOUSE ------------------------------------------------------------ Q9BGY9_MACFA Q9BGY9_MACFA ------------------------------------------------------------ A8K3I1_HUMAN A8K3I1_HUMAN GGGRGNT-------NTNECRMVDMHGMKVASFLMDGQELICLPQVFDLFLKHLVGGLHTV B1AJV3_HUMAN B1AJV3_HUMAN GGGRGNT-------NTNECRMVDMHGMKVASFLMDGQELICLPQVFDLFLKHLVGGLHTV Q1RMF5_HUMAN Q1RMF5_HUMAN ----------------AAVQWCDLGSLQLPPPRFKGFLCLSLPSSWNY------------ B4DQG3_HUMAN B4DQG3_HUMAN ------------------------------------------------------------ A8MW17_HUMAN A8MW17_HUMAN ---------------------------------------MAQNQFFN------------- B1AJV4_HUMAN B1AJV4_HUMAN GGGRGNT-------NTNECRMVDMHGMKVASFLMDGQELICLPQVFDLFLKHLVGGLHTV DACH2_HUMAN DACH2_HUMAN GGGRGNT-------NTNECRMVDMHGMKVASFLMDGQELICLPQVFDLFLKHLVGGLHTV B4DGA6_HUMAN B4DGA6_HUMAN ------------------------------------------------------------ B4DIK6_HUMAN B4DIK6_HUMAN ------------------------------------------------------------ Q9PTH2_CHICK Q9PTH2_CHICK GGGGG----------GNECKMVDLHGVKVASFLVEGQELICLPQVFDLFLKHLVGGLHTV Q5PQ18_XENLA Q5PQ18_XENLA --------------SSNECRMVDLHGAKIASFVLEGQELICLPQVFDLFLKHLVGGLHTV A4QNQ3_XENTR A4QNQ3_XENTR --------------SSSECRMVDLHGAKVASFVLEGQELICLPQVFDLFLKHLVGGLHTV A8E4U6_XENTR A8E4U6_XENTR --------------SSSECRMVDLHGAKVASFVLEGQELICLPQVFDLFLKHLVGGLHTV Q4RWD1_TETNG Q4RWD1_TETNG ----------------------------VSRHDPSNRTLASGDLCFQLW----------- Q1JPW1_DANRE Q1JPW1_DANRE KPVYSTPSPVENTPQNNECKMVEVRGAKLASFTVNGNELICLPQAFDLFLMHLVGGLHTV Q8QHJ1_DANRE Q8QHJ1_DANRE KPVYSTPSPVENTPQNNECKMVEVRGAKLASFTVNGNELICLLQAFDLFLKHLVGGLHTV B3DH35_DANRE B3DH35_DANRE KPVYSTPSPVENTPQNNECKMVEVRGAKLASFTVNGNELICLPQAFDLFLKHLVGGLHTV Q0PNF7_XENTR Q0PNF7_XENTR KPVYSTPSPVENIPQNNECRMVDLRGAKVASFTVDGSELICLPQAFDLFLKHLVGGLHTV Q70Q44_XENLA Q70Q44_XENLA KPVYSTPSPVENIPQNNECRMVELRGAKVASFTVETCELICLPQAFDLFLKHLVGGLHTV Q70Q63_XENLA Q70Q63_XENLA KPVYSTPSPVENIPQNNECRMVELRGAKVASFTVETCELICLPQAFDLFLKHLVGGLHTV B7ZRN2_XENLA B7ZRN2_XENLA KPVYSTPSPVENIPQNNECRMVELRGAKVASFTVETCELICLPQAFDLFLKHLVGGLHTV Q0PNF8_XENLA Q0PNF8_XENLA KPVYSTPSPVENIPQNNECRMVELRGAKVASFTVETCELICLPQAFDLFLKHLVGGLHTV Q8QHJ0_CHICK Q8QHJ0_CHICK KPVYSTPSPVENTPQNNECKMVDLRGAKVASFTVEGCELICLPQAFDLFLKHLVGGLHTV Q3UTV2_MOUSE Q3UTV2_MOUSE KPVYSTPSPVENTPQNNECKMVDLRGAKVASFTVEGCELICLPQAFDLFLKHLVGGLHTV DACH1_MOUSE DACH1_MOUSE KPVYSTPSPVENTPQNNECKMVDLRGAKVASFTVEGCELICLPQAFDLFLKHLVGGLHTV Q68G54_MOUSE Q68G54_MOUSE KPVYSTPSPVENTPQNNECKMVDLRGAKVASFTVEGCELICLPQAFDLFLKHLVGGLHTV A6NJF5_HUMAN A6NJF5_HUMAN KPVYSTPSPVENTPQNNECKMVDLRGAKVASFTVEGCELICLPQAFDLFLKHLVGGLHTV DACH1_HUMAN DACH1_HUMAN KPVYSTPSPVENTPQNNECKMVDLRGAKVASFTVEGCELICLPQAFDLFLKHLVGGLHTV A1L2G2_DANRE A1L2G2_DANRE KPVYSTPSPVENTPQNNECRMVELRGAKVASFTVDGQELICLPQAFDLFLKHLVGGLHTV Q8UUQ4_ORYLA Q8UUQ4_ORYLA KPVYATASPVESTPQNNECKLVEVKGAKLASFTVKDRELICLPQAFDVFLKHLVGGLHTV MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4T471_TETNG Q4T471_TETNG ------------------------------------------------------------ Q4SAZ0_TETNG Q4SAZ0_TETNG ------------------------------------------------------------ Q719M0_BRAFL Q719M0_BRAFL YTKLKRLDITPVVCNVEQVRILRGLGAIQPGVNRCKLLSKEEFDVLYEDCTNS------- B3DJL7_DANRE B3DJL7_DANRE YTKLKRLDINPVVCTVEQVRVLRGLGAIQPGVNRCKLISRKDFEALYNDCTNA------- Q8QHJ2_DANRE Q8QHJ2_DANRE YTKLKRLDINPVVCTVEQVRVLRGLGAIQPGVNRCKLISRKDFEALYNDCTNA------- B3DGP5_DANRE B3DGP5_DANRE YTKLKRLDICPVVCTVEQVRILRGLGAIQPGVNRCKLITRKDFETLYNDCTNA------- Q8QHJ3_DANRE Q8QHJ3_DANRE YTKLKRLDICPVVCTVEQVRILRGLGAIQPGVNRCKLITRKDFETLYNDCTNA------- B1AUM0_MOUSE B1AUM0_MOUSE YTKLKRLDISPVVCTVEQVRILRGLGAIQPGVNRCKLITRKDFETLFTDCTNA------- B1AU60_MOUSE B1AU60_MOUSE MTRKQAVN---------------------------------------------------- B1AU58_MOUSE B1AU58_MOUSE YTKLKRLDISPVVCTVEQVRILRGLGAIQPGVNRCKLITRKDFETLFTDCTNARRKRQMT DACH2_MOUSE DACH2_MOUSE YTKLKRLDISPVVCTVEQVRILRGLGAIQPGVNRCKLITRKDFETLFTDCTNARRKRQMT B1AU59_MOUSE B1AU59_MOUSE MTRKQAVN---------------------------------------------------- B1AXA6_MOUSE B1AXA6_MOUSE ------------------------------------------------------------ Q9BGY9_MACFA Q9BGY9_MACFA ------------------------------------------------------------ A8K3I1_HUMAN A8K3I1_HUMAN YTELKRLDISPVVCTVEQVRILRGLGAIQPGVNRCKLITRKDFETLFTDCTNARRKRQMT B1AJV3_HUMAN B1AJV3_HUMAN YTKLKRLDISPVVCTVEQVRILRGLGAIQPGVNRCKLITRKDFETLFTDCTNA------- Q1RMF5_HUMAN Q1RMF5_HUMAN ------------------------------------------------------------ B4DQG3_HUMAN B4DQG3_HUMAN MTRKQAVN---------------------------------------------------- A8MW17_HUMAN A8MW17_HUMAN ------------------------------------------------------------ B1AJV4_HUMAN B1AJV4_HUMAN YTKLKRLDISPVVCTVEQVRILRGLGAIQPGVNRCKLITRKDFETLFTDCTNA------- DACH2_HUMAN DACH2_HUMAN YTKLKRLDISPVVCTVEQVRILRGLGAIQPGVNRCKLITRKDFETLFTDCTNARRKRQMT B4DGA6_HUMAN B4DGA6_HUMAN ------------------------------------------------------------ B4DIK6_HUMAN B4DIK6_HUMAN ------------------------------------------------------------ Q9PTH2_CHICK Q9PTH2_CHICK YTKLKRLDISPVVCTVEQVRILRGLGAIQPGVNRCKLITRKDFETLYNDCTNA------- Q5PQ18_XENLA Q5PQ18_XENLA YTKLKRLDITPVVCTVEQVRVLRGLGAIQPGVNRCKLISRRDFETLYNDCTNA------- A4QNQ3_XENTR A4QNQ3_XENTR YTKLKRLDITPVVCTVEQVRVLRGLGAIQPGVNRCKLISRRDFETLYNDCTNA------- A8E4U6_XENTR A8E4U6_XENTR YTKLKRLDITPVVCTVEQVRVLRGLGAIQPGVNRCKLISRRDFETLYNDCTNA------- Q4RWD1_TETNG Q4RWD1_TETNG ----REFEVTDCLHNSVQACY-------------CEL-----------QCSKA------- Q1JPW1_DANRE Q1JPW1_DANRE YTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFEVLYNDCTNA------- Q8QHJ1_DANRE Q8QHJ1_DANRE YTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFEVLYNDCTNA------- B3DH35_DANRE B3DH35_DANRE YTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFEVLYNDCTNA------- Q0PNF7_XENTR Q0PNF7_XENTR YTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYNDCTNA------- Q70Q44_XENLA Q70Q44_XENLA YTKLKRLEISPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYNDCTNA------- Q70Q63_XENLA Q70Q63_XENLA YTKLKRLEISPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYNDCTNA------- B7ZRN2_XENLA B7ZRN2_XENLA YTKLKRLEISPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYNDCTNA------- Q0PNF8_XENLA Q0PNF8_XENLA YTKLKRLEISPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYNDCTNA------- Q8QHJ0_CHICK Q8QHJ0_CHICK YTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYNDCTNA------- Q3UTV2_MOUSE Q3UTV2_MOUSE YTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYNDCTNA------- DACH1_MOUSE DACH1_MOUSE YTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYNDCTNA------- Q68G54_MOUSE Q68G54_MOUSE YTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYNDCTNA------- A6NJF5_HUMAN A6NJF5_HUMAN YTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYNDCTNA------- DACH1_HUMAN DACH1_HUMAN YTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYNDCTNA------- A1L2G2_DANRE A1L2G2_DANRE YTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYNDCTNA------- Q8UUQ4_ORYLA Q8UUQ4_ORYLA YTKLKRLDITPVVCNVEQVRVLRGLGAIQPGVNRCKLISRKGFETLYNDCTNA------- MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4T471_TETNG Q4T471_TETNG --------------------------------------------PAGLTA---------- Q4SAZ0_TETNG Q4SAZ0_TETNG --------------------------------------------MSGLTA---------- Q719M0_BRAFL Q719M0_BRAFL ------SSRP-GRPPKRAQ--------------------PPLMPPL-------------- B3DJL7_DANRE B3DJL7_DANRE ------SSRP-GRPPKRSYGASVQESPRILHHRA-NLLSPALLSPTGLTT---------- Q8QHJ2_DANRE Q8QHJ2_DANRE ------SSRP-GRPPKRSYGASVQESPRILHHRA-NLLSPALLSPTGLTT---------- B3DGP5_DANRE B3DGP5_DANRE ------SSRP-GRPPKRSLGVAMQDSSRLLPHSVHGLLSPGLLSPTGLTA---------- Q8QHJ3_DANRE Q8QHJ3_DANRE ------SSRP-GRPPKRSLGVAMQDSSRLLPHSVHGLLSPGLLSPTGLTA---------- B1AUM0_MOUSE B1AUM0_MOUSE ------SSRP-GRPPKRSLGV-LQDNARLLPHAVPGLLSPGLITPTGITA---------- B1AU60_MOUSE B1AU60_MOUSE ------SSRP-GRPPKRSLGV-LQDNARLLPHAVPGLLSPGLITPTGITA---------- B1AU58_MOUSE B1AU58_MOUSE RKQAVNSSRP-GRPPKRSLGV-LQDNARLLPHAVPGLLSPGLITPTGITA---------- DACH2_MOUSE DACH2_MOUSE RKQAVNSSRP-GRPPKRSLGV-LQDNARLLPHAVPGLLSPGLITPTGITA---------- B1AU59_MOUSE B1AU59_MOUSE ------SSRP-GRPPKRSLGV-LQDNARLLPHAVPGLLSPGLITPTGITA---------- B1AXA6_MOUSE B1AXA6_MOUSE ------------------------------------------------------------ Q9BGY9_MACFA Q9BGY9_MACFA ------------------------------------------------------------ A8K3I1_HUMAN A8K3I1_HUMAN RKQAVNSSRP-GRPPKRSLGV-LQENARLLTHAVPGLLSPGLITPTGITA---------- B1AJV3_HUMAN B1AJV3_HUMAN ------SSRP-GRPPKRSLGV-LQENARLLTHAVPGLLSPGLITPTGITA---------- Q1RMF5_HUMAN Q1RMF5_HUMAN ------SSRP-GRPPKRSLGV-LQENARLLTHAVPGLLSPGLITPTGITA---------- B4DQG3_HUMAN B4DQG3_HUMAN ------SSRP-GRPPKRSLGV-LQENARLLTHAVPGLLSPGLITPTGITA---------- A8MW17_HUMAN A8MW17_HUMAN ------SSRP-GRPPKRSLGV-LQENARLLTHAVPGLLSPGLITPTGITA---------- B1AJV4_HUMAN B1AJV4_HUMAN ------SSRP-GRPPKRSLGV-LQENARLLTHAVPGLLSPGLITPTGITA---------- DACH2_HUMAN DACH2_HUMAN RKQAVNSSRP-GRPPKRSLGV-LQENARLLTHAVPGLLSPGLITPTGITA---------- B4DGA6_HUMAN B4DGA6_HUMAN ------------------------------------------------------------ B4DIK6_HUMAN B4DIK6_HUMAN ------------------------------------------------------------ Q9PTH2_CHICK Q9PTH2_CHICK ------SSRP-GRPPKRSLGVAIQENARLLPHGVPGLLSPGLISPTGLTA---------- Q5PQ18_XENLA Q5PQ18_XENLA ------SSRP-GRPPKRSLGVGIQENARLLTHGVPGLLSPGLISPTGLTA---------- A4QNQ3_XENTR A4QNQ3_XENTR ------SSRP-GRPPKRSLGVGIQENARLLPHGVPGLLSPGLLSPTGLTA---------- A8E4U6_XENTR A8E4U6_XENTR ------SSRP-GRPPKRSLGVGIQENARLLPHGVPGLLSPGLLSPTGLTA---------- Q4RWD1_TETNG Q4RWD1_TETNG ------KVREYQKAPMRHS------------------FEQHLICLTAAAA------AAAN Q1JPW1_DANRE Q1JPW1_DANRE ------SSRP-GRPPKRTQNVTSPDSPHVLPHSVSGLMSSGLMSHTGLTA---------- Q8QHJ1_DANRE Q8QHJ1_DANRE ------SSRP-GRPPKRTQNVTSPDSPHVLPHSVSGLMSSGLMSHTGLTA---------- B3DH35_DANRE B3DH35_DANRE ------SSRP-GRPPKRTQNVTSPDSPHVLPHSVSGLMSSGLMSHTGLTA---------- Q0PNF7_XENTR Q0PNF7_XENTR ------SSRP-GRPPKRTQSVTXPDNPHIMPHTVPGLMSPGMIPPTGLTAAAAXAAAATN Q70Q44_XENLA Q70Q44_XENLA ------SSRP-GRPPKRTQSVTSSDNPHIMPHTVPGLMSPGMIPPTGLTAAAAAAAAATN Q70Q63_XENLA Q70Q63_XENLA ------SSRP-GRPPKRTQSVTSSDNPHIMPHTVPGLMSPGMIPPTGLTAAAAAAAAATN B7ZRN2_XENLA B7ZRN2_XENLA ------SSRP-GRPPKRTQSVTSSDNPHIMPHTVPGLMSPGMISPTGLTAAAAAAAAATN Q0PNF8_XENLA Q0PNF8_XENLA ------SSRP-GRPPKRTQSVTSSDNPHIMPHTVPGLMSPGMISPTGLTAAAAAAAAATN Q8QHJ0_CHICK Q8QHJ0_CHICK ------SSRP-GRPPKRTQSVTSPENSHIMPHSVPGLMSPGIIPPTGLTAAAAAAAAATN Q3UTV2_MOUSE Q3UTV2_MOUSE ------SSRP-GRPPKRTQSVTSPENSHIMSHSVPGLMSPGIIPPTGLTAAAAAAAAATN DACH1_MOUSE DACH1_MOUSE ------SSRP-GRPPKRTQSVTSPENSHIMPHSVPGLMSPGIIPPTGLTAAAAAAAAATN Q68G54_MOUSE Q68G54_MOUSE ------SSRP-GRPPKRTQSVTSPENSHIMPHSVPGLMSPGIIPPTGLTAAAAAAAAATN A6NJF5_HUMAN A6NJF5_HUMAN ------SSRP-GRPPKRTQSVTSPENSHIMPHSVPGLMSPGIIPPTGLTAAAAAAAAATN DACH1_HUMAN DACH1_HUMAN ------SSRP-GRPPKRTQSVTSPENSHIMPHSVPGLMSPGIIPPTGLTAAAAAAAAATN A1L2G2_DANRE A1L2G2_DANRE ------SSRP-GRPPKRTQSVTSPENPHIMPHTVPGLMSPGIIPPTGLTAAAAAAAAATN Q8UUQ4_ORYLA Q8UUQ4_ORYLA ------SSRP-GRPPKRTQSVTSTENPHIMPHSVPGLMSPGMIPPTGLTA---AAAAAAN MATCH CONSENSUS ??????SSRP?GRPPKR??????????????H????L?S??????TG?TA??????????

Q4T471_TETNG Q4T471_TETNG ATMAEALALQKMRM--MMGFHGNSEQPWHQDADRTASPSDLD-DTGA--SEGSWEKEQRV Q4SAZ0_TETNG Q4SAZ0_TETNG AAMAELQKLQKMKMMM-------SLQ-----NGNESDNDDLHSNTGG--SECSWDKERLT Q719M0_BRAFL Q719M0_BRAFL -----IHDHKKLHLE----------------NG--------------------------- B3DJL7_DANRE B3DJL7_DANRE AAMAEALKIQKMKM--MMNLH--KTH-----NGSEFDSDELNSNAGTVCSTLSWEREKHS Q8QHJ2_DANRE Q8QHJ2_DANRE AAMAEALKIQKMKM--MMNLH--KTH-----NGSEFDSDELNSNAGTVCSTLSWEREKHS B3DGP5_DANRE B3DGP5_DANRE AAMAEAMKLQKMKLMAMNNIHGAGSQ-----NGTESENEELNSSAGG--SESSWDKEKLQ Q8QHJ3_DANRE Q8QHJ3_DANRE AAMAEAMKLQKMKLMAMNNIHGAGSQ-----NGTESENEELNSSAGG--SESSWDKEKLQ B1AUM0_MOUSE B1AUM0_MOUSE AAMAEAMKLQKMKLMAMNTLQGNGSQ-----NGTESEPDDLNSTTGG--SESSWDKDKIQ B1AU60_MOUSE B1AU60_MOUSE AAMAEAMKLQKMKLMAMNTLQGNGSQ-----NGTESEPDDLNSTTGG--SESSWDKDKIQ B1AU58_MOUSE B1AU58_MOUSE AAMAEAMKLQKMKLMAMNTLQGNGSQ-----NGTESEPDDLNSTTGG--SESSWDKDKIQ DACH2_MOUSE DACH2_MOUSE AAMAEAMKLQKMKLMAMNTLQGNGSQ-----NGTESEPDDLNSTTGG--SESSWDKDKIQ B1AU59_MOUSE B1AU59_MOUSE AAMAEAMKLQKMKLMAMNTLQGNGSQ-----NGTESEPDDLNSTTGG--SESSWDKDKIQ B1AXA6_MOUSE B1AXA6_MOUSE --MAEAMKLQKMKLMAMNTLQGNGSQ-----NGTESEPDDLNSTTGG--SESSWDKDKIQ Q9BGY9_MACFA Q9BGY9_MACFA ------------------------------------------------------------ A8K3I1_HUMAN A8K3I1_HUMAN AAMAEAMKLQKMKLMAMNTLQGNGSQ-----NGTESEPDDLNSNTGG--SESSWDKDKMQ B1AJV3_HUMAN B1AJV3_HUMAN AAMAEAMKLQKMKLMAMNTLQGNGSQ-----NGTESEPDDLNSNTGG--SESSWDKDKMQ Q1RMF5_HUMAN Q1RMF5_HUMAN AAMAEAMKLQKMKLMAMNTLQGNGSQ-----NGTESEPDDLNSNTGG--SESSWDKDKMQ B4DQG3_HUMAN B4DQG3_HUMAN AAMAEAMKLQKMKLMAMNTLQGNGSQ-----NGTESEPDDLNSNTGG--SESSWDKDKMQ A8MW17_HUMAN A8MW17_HUMAN AAMAEAMKLQKMKLMAMNTLQGNGSQ-----NGTESEPDDLNSNTGG--SESSWDKDKMQ B1AJV4_HUMAN B1AJV4_HUMAN AAMAEAMKLQKMKLMAMNTLQGNGSQ-----NGTESEPDDLNSNTGG--SESSWDKDKMQ DACH2_HUMAN DACH2_HUMAN AAMAEAMKLQKMKLMAMNTLQGNGSQ-----NGTESEPDDLNSNTGG--SESSWDKDKMQ B4DGA6_HUMAN B4DGA6_HUMAN ------------------------------------------------------------ B4DIK6_HUMAN B4DIK6_HUMAN ------------------------------------------------------------ Q9PTH2_CHICK Q9PTH2_CHICK AAMAEAMKLQKMKLMAMNSLHGSGSQ-----NGTESENEELNSNAGG--SESSWDKDKLQ Q5PQ18_XENLA Q5PQ18_XENLA AAMAEAMKLQKMKMMAINSLHGSGSQ-----NGTESENEELNSNAGG--SESSWDKDKLQ A4QNQ3_XENTR A4QNQ3_XENTR AAMAEAMKLQKMKMMAINSLHGSGSQ-----NGTESENEELNSNAGG--SESSWDKDKLQ A8E4U6_XENTR A8E4U6_XENTR AAMAEAMKLQKMKMMAINSLHGSGSQ-----NGTESENEELNSNAGG--SESSWDKDKLQ Q4RWD1_TETNG Q4RWD1_TETNG AAIAEAMKVKKIKLEAMSSYHSNANH-----HGGDGENGDLSSSVGL------------- Q1JPW1_DANRE Q1JPW1_DANRE ATLAEAMK-KKIKLEVMNSYHGNNN------HSADSENGDITSSMGL------------- Q8QHJ1_DANRE Q8QHJ1_DANRE ATLAEAMK-KKIKLEVMNSYHGNNN------HSADSENGDITSSMGL------------- B3DH35_DANRE B3DH35_DANRE ATLAEAMK-KKIKLEVMNSYHGNNN------HSADSENGDITSSMGL------------- Q0PNF7_XENTR Q0PNF7_XENTR AAIAEAMKVKKIKLEAMTNYHGSNNQ-----HGADSDNGDLNSSVGL------------- Q70Q44_XENLA Q70Q44_XENLA AAIAEAMKVKKIKLEAMTNYHGNNQ------HGADSDNGDLNSSLGL------------- Q70Q63_XENLA Q70Q63_XENLA AAIAEAMKVKKIKLEAMTNYHG-NNQ-----HGADSDNGDLNSSLGS--SDGSWDKEKLQ B7ZRN2_XENLA B7ZRN2_XENLA AAIAEAMKVKKIKLEAMTNYHGSNNQ-----HGADSDNGDFSSSVGL------------- Q0PNF8_XENLA Q0PNF8_XENLA AAIAEAMKVKKIKLEAMTNYHGSNNQ-----HGADSDNGDFSSSVGN--SDGSWDKEKLQ Q8QHJ0_CHICK Q8QHJ0_CHICK AAIAEAMKVKKIKLEAMSNYHANNNQ-----HGADSENGDLNSSVGL------------- Q3UTV2_MOUSE Q3UTV2_MOUSE AAIAEAMKVKKIKLEAMSNYHASNNQ-----HGADSENGDMNSSVGL------------- DACH1_MOUSE DACH1_MOUSE AAIAEAMKVKKIKLEAMSNYHASNNQ-----HGADSENGDMNSSVGS--SGGSWDKETLH Q68G54_MOUSE Q68G54_MOUSE AAIAEAMKVKKIKLEAMSNYHASNNQ-----HGADSENGDMNSSVGL------------- A6NJF5_HUMAN A6NJF5_HUMAN AAIAEAMKVKKIKLEAMSNYHASNNQ-----HGADSENGDMNSSVGS--SDGSWDKETLP DACH1_HUMAN DACH1_HUMAN AAIAEAMKVKKIKLEAMSNYHASNNQ-----HGADSENGDMNSSVGS--SDGSWDKETLP A1L2G2_DANRE A1L2G2_DANRE AAIAEAMKVKKIKLEVMSSYHGSNTH-----NGPDSENGDLSSSVGL------------- Q8UUQ4_ORYLA Q8UUQ4_ORYLA AAIAEAMKVKKIKLEAMSSYHGNANH-----HGADGENGDLGSSVGL------------- MATCH CONSENSUS A??AEAMK??K?K???M???????????????G?????????S??G??????????????

Q4T471_TETNG Q4T471_TETNG LP-----TPLSVAIAPPPG---------------------------SASLRLNSLQQRSA Q4SAZ0_TETNG Q4SAZ0_TETNG SPPTGAHSGGPGGGAGAPGGAAAGGGGSGTGGGGGGGGGGGRGPAIGAVSQQQIQQQ-QQ Q719M0_BRAFL Q719M0_BRAFL ------------------------------------------------------------ B3DJL7_DANRE B3DJL7_DANRE SPASEK-TQHSLNNSQ-----------------------------------LNSLQH-TH Q8QHJ2_DANRE Q8QHJ2_DANRE SPASEK-TQHSLNNSQ-----------------------------------LNSLQH-TH B3DGP5_DANRE B3DGP5_DANRE SPPSSG-AQHGLAHAALSA-----------------------QHGLSGSH-LSSLQQ-SH Q8QHJ3_DANRE Q8QHJ3_DANRE SPPSSG-AQHGLAHAALSA-----------------------QHGLSGSH-LSSLQQ-SH B1AUM0_MOUSE B1AUM0_MOUSE SPLAASGPQHGIAHAALAG-----------------------QPGLGGAPTLNPLQQ-NH B1AU60_MOUSE B1AU60_MOUSE SPLAASGPQHGIAHAALAG-----------------------QPGLGGAPTLNPLQQ-NH B1AU58_MOUSE B1AU58_MOUSE SPLAASGPQHGIAHAALAG-----------------------QPGLGGAPTLNPLQQ-NH DACH2_MOUSE DACH2_MOUSE SPLAASGPQHGIAHAALAG-----------------------QPGLGGAPTLNPLQQ-NH B1AU59_MOUSE B1AU59_MOUSE SPLAASGPQHGIAHAALAG-----------------------QPGLGGAPTLNPLQQ-NH B1AXA6_MOUSE B1AXA6_MOUSE SPLAASGPQHGIAHAALAG-----------------------QPGLGGAPTLNPLQQ-NH Q9BGY9_MACFA Q9BGY9_MACFA ------------------------------------------------------------ A8K3I1_HUMAN A8K3I1_HUMAN SPFAAPGPQHGIAHAALAV-----------------------QPGIGGAPTLNPLQQ-NH B1AJV3_HUMAN B1AJV3_HUMAN SPFAAPGPQHGIAHAALAG-----------------------QPGIGGAPTLNPLQQ-NH Q1RMF5_HUMAN Q1RMF5_HUMAN SPFAAPGPQHGIAHAALAG-----------------------QPGIGGAPTLNPLQQ-NH B4DQG3_HUMAN B4DQG3_HUMAN SPFAAPGPQHGIAHAALAG-----------------------QPGIGGAPTLNPLQQ-NH A8MW17_HUMAN A8MW17_HUMAN SPFAAPGPQHGIAHAALAG-----------------------QPGIGGAPTLNPLQQ-NH B1AJV4_HUMAN B1AJV4_HUMAN SPFAAPGPQHGIAHAALAG-----------------------QPGIGGAPTLNPLQQ-NH DACH2_HUMAN DACH2_HUMAN SPFAAPGPQHGIAHAALAG-----------------------QPGIGGAPTLNPLQQ-NH B4DGA6_HUMAN B4DGA6_HUMAN ------------------------------------------------------------ B4DIK6_HUMAN B4DIK6_HUMAN ------------------------------------------------------------ Q9PTH2_CHICK Q9PTH2_CHICK SPITTG-SQHSIGHPTLSG-----------------------QSSLGSAHPLSPLQQ-NH Q5PQ18_XENLA Q5PQ18_XENLA SPITTTVSQHGMGHVTLSG-----------------------QASLGG-HPLSPLQQ-NH A4QNQ3_XENTR A4QNQ3_XENTR SPITTG-SQHGIGHVTLSG-----------------------QASLG-AHPLSPLQQ-NH A8E4U6_XENTR A8E4U6_XENTR SPITTG-SQHGIGHVTLSG-----------------------QASLG-AHPLSPLQQ-NH Q4RWD1_TETNG Q4RWD1_TETNG ------------------------------------------------------------ Q1JPW1_DANRE Q1JPW1_DANRE ------------------------------------------------------------ Q8QHJ1_DANRE Q8QHJ1_DANRE ------------------------------------------------------------ B3DH35_DANRE B3DH35_DANRE ------------------------------------------------------------ Q0PNF7_XENTR Q0PNF7_XENTR ------------------------------------------------------------ Q70Q44_XENLA Q70Q44_XENLA ------------------------------------------------------------ Q70Q63_XENLA Q70Q63_XENLA SLPTQG-SQTSLSHPNLPG-----------------------QHNLSVTHPLNTLQQ-NH B7ZRN2_XENLA B7ZRN2_XENLA ------------------------------------------------------------ Q0PNF8_XENLA Q0PNF8_XENLA SLPTQG-SQTSLSHPNLPG-----------------------QHNLSVTHSLNSLQQ-NH Q8QHJ0_CHICK Q8QHJ0_CHICK ------------------------------------------------------------ Q3UTV2_MOUSE Q3UTV2_MOUSE ------------------------------------------------------------ DACH1_MOUSE DACH1_MOUSE SPPSQG-SQAPVAHARMPA-----------------------AFSLPVSHPLNHLQH-SH Q68G54_MOUSE Q68G54_MOUSE ------------------------------------------------------------ A6NJF5_HUMAN A6NJF5_HUMAN SSPSQG-PQASITHPRMPG-----------------------ARSLPLSHPLNHLQQ-SH DACH1_HUMAN DACH1_HUMAN SSPSQG-PQASITHPRMPG-----------------------ARSLPLSHPLNHLQQ-SH A1L2G2_DANRE A1L2G2_DANRE ------------------------------------------------------------ Q8UUQ4_ORYLA Q8UUQ4_ORYLA ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4T471_TETNG Q4T471_TETNG LLANRLADLPFMVMPHPLLPVGLPPAGVAMAMNQMSQLSGLANMAAIS-QIREEDSKVRD Q4SAZ0_TETNG Q4SAZ0_TETNG LLANRL-DLPFMMMPHPLLPMGLPPASVAMAMSQMNHLNTIANMAAAAQQIHTHVHR--A Q719M0_BRAFL Q719M0_BRAFL -------DFDF--------------------------------------TGHT------- B3DJL7_DANRE B3DJL7_DANRE LLANRL-ELPFMMMPHPLLPVGLPPASVAMAMNQMNHLNTIANMVASA-QVHSPVSRPTS Q8QHJ2_DANRE Q8QHJ2_DANRE LLANRL-ELPFMMMPHPLLPVGLPPASVAMAMNQMNHLNTIANMVASA-QVHSPVSRPTS B3DGP5_DANRE B3DGP5_DANRE LLANRL-DLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAA-QMHSPLSRAGA Q8QHJ3_DANRE Q8QHJ3_DANRE LLANRL-DLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAA-QMHSPLSRAGA B1AUM0_MOUSE B1AUM0_MOUSE LLSNRL-DLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAA-QIHSPLSRAGA B1AU60_MOUSE B1AU60_MOUSE LLSNRL-DLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAA-QIHSPLSRAGA B1AU58_MOUSE B1AU58_MOUSE LLSNRL-DLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAA-QIHSPLSRAGA DACH2_MOUSE DACH2_MOUSE LLSNRL-DLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAA-QIHSPLSRAGA B1AU59_MOUSE B1AU59_MOUSE LLSNRL-DLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAA-QIHSPLSRAGA B1AXA6_MOUSE B1AXA6_MOUSE LLSNRL-DLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAA-QIHSPLSRAGA Q9BGY9_MACFA Q9BGY9_MACFA -------------------------------------------MAAAA-QIHSPLSRAGT A8K3I1_HUMAN A8K3I1_HUMAN LLTNRL-DLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAA-QIHSPLSRAGT B1AJV3_HUMAN B1AJV3_HUMAN LLTNRL-DLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAA-QIHSPLSRAGT Q1RMF5_HUMAN Q1RMF5_HUMAN LLTNRL-DLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAA-QIHSPLSRAGT B4DQG3_HUMAN B4DQG3_HUMAN LLTNRL-DLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAA-QIHSPLSRAGT A8MW17_HUMAN A8MW17_HUMAN LLTNRL-DLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAA-QIHSPLSRAGT B1AJV4_HUMAN B1AJV4_HUMAN LLTNRL-DLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAA-QIHSPLSRAGT DACH2_HUMAN DACH2_HUMAN LLTNRL-DLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAA-QIHSPLSRAGT B4DGA6_HUMAN B4DGA6_HUMAN -------------------------------------------MAAAA-QIHSPLSRAGT B4DIK6_HUMAN B4DIK6_HUMAN -------------------------------------------MAAAA-QIHSPLSRAGT Q9PTH2_CHICK Q9PTH2_CHICK LLTNRI-DLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAA-QMHSPLSRAGA Q5PQ18_XENLA Q5PQ18_XENLA LLANRL-DLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAA-QMHSPLSRMGA A4QNQ3_XENTR A4QNQ3_XENTR LLANRL-DLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAA-QMHSPLSRVGA A8E4U6_XENTR A8E4U6_XENTR LLANRL-DLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAA-QMHSPLSRVGA Q4RWD1_TETNG Q4RWD1_TETNG -------ELPFMMMPHPLIPVSLPPASVTMAMSQMNHLSTIANMAAAA-QGQSLPSRMVT Q1JPW1_DANRE Q1JPW1_DANRE -------ELPFMMMPHPLISVSLPPASVTMAMNQMNHLSTIASVAAAA-QVQSVPSRMVT Q8QHJ1_DANRE Q8QHJ1_DANRE -------ELPFMMMPHPLIPVSLPPASVTMAMNQMNHLSTIASMAAAA-QVQSVPSRMVT B3DH35_DANRE B3DH35_DANRE -------ELPFMMMPHPLIPVSLPPASVTMAMNQMNHLSTIASMAAAA-QVQSVPSRMVT Q0PNF7_XENTR Q0PNF7_XENTR -------ELPFMMMPHPLIPVSLPPASVTMAMSQMNHLSTIANMAAAA-QVHSTPSRVET Q70Q44_XENLA Q70Q44_XENLA -------EIPFMMMPHPLIPVSLPPASVTMAMSQMNHLSTIASMAAAA-QVQSTPSRVET Q70Q63_XENLA Q70Q63_XENLA LLPNGL-EIPFMMMPHPLIPVSLPPASVTMAMSQMNHLSTIASMAAAA-QVQSTPSRVET B7ZRN2_XENLA B7ZRN2_XENLA -------ELPFMMMPHPLIPVSLPHASVTMAMSQMNHLSTIANMAAAA-QVQSTPSRMET Q0PNF8_XENLA Q0PNF8_XENLA LLPNGL-ELPFMMMPHPLIPVSLPHASVTMAMSQMNHLSTIANMAAAA-QVQSTPSRMET Q8QHJ0_CHICK Q8QHJ0_CHICK -------ELPFMMMPHPLIPVSLPPASVTMAMSQMNHLSTIANMAAAA-QVQSPPSRVET Q3UTV2_MOUSE Q3UTV2_MOUSE -------ELPFMMMPHPLIPVSLPPASVTMAMSQMNHLSTIANMAAAA-QVQSPPSRVET DACH1_MOUSE DACH1_MOUSE LPPNGL-ELPFMMMPHPLIPVSLPPASVTMAMSQMNHLSTIANMAAAA-QVQSPPSRVET Q68G54_MOUSE Q68G54_MOUSE -------ELPFMMMPHPLIPVSLPPASVTMAMSQMNHLSTIANMAAAA-QVQSPPSRVET A6NJF5_HUMAN A6NJF5_HUMAN LLPNGL-ELPFMMMPHPLIPVSLPPASVTMAMSQMNHLSTIANMAAAA-QVQSPPSRVET DACH1_HUMAN DACH1_HUMAN LLPNGL-ELPFMMMPHPLIPVSLPPASVTMAMSQMNHLSTIANMAAAA-QVQSPPSRVET A1L2G2_DANRE A1L2G2_DANRE -------ELPFMMMPHPLIPVSLPPASVTMAMSQMNHLSTIANMAAAA-QGQSAPSRMVT Q8UUQ4_ORYLA Q8UUQ4_ORYLA -------ELPFMMMPHPLIPVSLPPASVTMAMSQMNHLSTIANMAAAA-QGQSLPSRMVT MATCH : CONSENSUS ????????LPFMMMPHPL?PVSLPPASV?MAM?QMNHL?TIA?MAAAA?Q??S??SR???

Q4T471_TETNG Q4T471_TETNG Q--------------------RKLVSSHSEDANIFASQSPPGTPSLSPSPSDDEPQLPEA Q4SAZ0_TETNG Q4SAZ0_TETNG PVIK-----------------ERVCDSPSLSPSVDEANTP---LQSQPSSS--------- Q719M0_BRAFL Q719M0_BRAFL -----------------------------PIDSLES---PDSHSEGHPSM---------- B3DJL7_DANRE B3DJL7_DANRE AIKQ-----------------ERFEESPSLTPSVEGIVSQKTEPSPQQSSS--------- Q8QHJ2_DANRE Q8QHJ2_DANRE AIKQ-----------------ERFEESPSLTPSVEGIVSQKTEPSPQQSSS--------- B3DGP5_DANRE B3DGP5_DANRE SVIK-----------------ECVQDSPSPTPSLEEAPRPGSQPSSHPSSS--------- Q8QHJ3_DANRE Q8QHJ3_DANRE SVIK-----------------ECVQDSPSPTPSLEEAPRPGSQPSSHPSSS--------- B1AUM0_MOUSE B1AUM0_MOUSE SVIK-----------------ERIPESPSPAPSLEESHRPGSQTSSHPSSS--------- B1AU60_MOUSE B1AU60_MOUSE SVIK-----------------ERIPESPSPAPSLEESHRPGSQTSSHPSSS--------- B1AU58_MOUSE B1AU58_MOUSE SVIK-----------------ERIPESPSPAPSLEESHRPGSQTSSHPSSS--------- DACH2_MOUSE DACH2_MOUSE SVIK-----------------ERIPESPSPAPSLEESHRPGSQTSSHPSSS--------- B1AU59_MOUSE B1AU59_MOUSE SVIK-----------------ERIPESPSPAPSLEESHRPGSQTSSHPSSS--------- B1AXA6_MOUSE B1AXA6_MOUSE SVIK-----------------ERIPESPSPAPSLEESHRPGSQTSSHPSSS--------- Q9BGY9_MACFA Q9BGY9_MACFA SVIK-----------------ERIPESPSPAPSLEENHRPGSQTSSHSSSS--------- A8K3I1_HUMAN A8K3I1_HUMAN SVIK-----------------ERIPESPSPAPSLEENHRPGSQTSSHTSSS--------- B1AJV3_HUMAN B1AJV3_HUMAN SVIK-----------------ERIPESPSPAPSLEENHRPGSQTSSHTSSS--------- Q1RMF5_HUMAN Q1RMF5_HUMAN SVIK-----------------ERIPESPSPAPSLEENHRPGSQTSSHTSSS--------- B4DQG3_HUMAN B4DQG3_HUMAN SVIK-----------------ERIPESPSPAPSLEENHRPGSQTSSHTSSS--------- A8MW17_HUMAN A8MW17_HUMAN SVIK-----------------ERIPESPSPAPSLEENHRPGSQTSSHTSSS--------- B1AJV4_HUMAN B1AJV4_HUMAN SVIK-----------------ERIPESPSPAPSLEENHRPGSQTSSHTSSS--------- DACH2_HUMAN DACH2_HUMAN SVIK-----------------ERIPESPSPAPSLEENHRPGSQTSSHTSSS--------- B4DGA6_HUMAN B4DGA6_HUMAN SVIK-----------------ERIPESPSPAPSLEENHRPGSQTSSHTSSS--------- B4DIK6_HUMAN B4DIK6_HUMAN SVIK-----------------ERIPESPSPAPSLEENHRPGSQTSSHTSSS--------- Q9PTH2_CHICK Q9PTH2_CHICK SVIK-----------------ERIQDSPSPAPSLEDSQRPGSHASSHQSSS--------- Q5PQ18_XENLA Q5PQ18_XENLA SVIKVVSAWQIDKMKLHPQHNERIQDTPSPAPSIEDSQRPGSHASSHQSSS--------- A4QNQ3_XENTR A4QNQ3_XENTR SVIK-----------------ERIQDTPSPAPSIEDTQRPGSHASSHQSSS--------- A8E4U6_XENTR A8E4U6_XENTR SVIK-----------------ERIQDTPSPAPSIEDTQRPGSHASSHQSSS--------- Q4RWD1_TETNG Q4RWD1_TETNG SVIKGL--------------QERVPDSPSPAPSLEDHRRPGSHPSSHRSSS--------- Q1JPW1_DANRE Q1JPW1_DANRE SVIK-----------------ERVPDSPSPVPSLDDGRRSGSHLSSRQSSS--------- Q8QHJ1_DANRE Q8QHJ1_DANRE SVIK-----------------ERVPDSPSPVPSLDDGRRSGSHLSSRQSSS--------- B3DH35_DANRE B3DH35_DANRE SVIK-----------------ERVPDSPSPVPSLDDGRRSGSHLSSRQSSS--------- Q0PNF7_XENTR Q0PNF7_XENTR SVIK-----------------ERVPDSPSPAPSLEDGRRPVSHPSSHRSSS--------- Q70Q44_XENLA Q70Q44_XENLA SVIK-----------------ERVPDSPSPAPSLEDGRRPVSHPSSHRSSS--------- Q70Q63_XENLA Q70Q63_XENLA SVIK-----------------ERVPDSPSPAPSLEDGRRPVSHPSSHRSSS--------- B7ZRN2_XENLA B7ZRN2_XENLA SVIK-----------------ERVPDSPSPAPSLEDGRRPVSHPSSHRSSS--------- Q0PNF8_XENLA Q0PNF8_XENLA SVIK-----------------ERVPDSPSPAPSLEDGRRPVSHPSSHRSSS--------- Q8QHJ0_CHICK Q8QHJ0_CHICK SVIK-----------------ERVPDSPSPAPSLEEGRRPGSHPSSHRSSS--------- Q3UTV2_MOUSE Q3UTV2_MOUSE SVIK-----------------ERVPDSPSPAPSLEEGRRPGSHPSSHRSSS--------- DACH1_MOUSE DACH1_MOUSE SVIK-----------------ERVPDSPSPAPSLEEGRRPGSHPSSHRSSS--------- Q68G54_MOUSE Q68G54_MOUSE SVIK-----------------ERVPDSPSPAPSLEEGRRPGSHPSSHRSSS--------- A6NJF5_HUMAN A6NJF5_HUMAN SVIK-----------------ERVPDSPSPAPSLEEGRRPGSHPSSHRSSS--------- DACH1_HUMAN DACH1_HUMAN SVIK-----------------ERVPDSPSPAPSLEEGRRPGSHPSSHRSSS--------- A1L2G2_DANRE A1L2G2_DANRE SVIK-----------------ERVPDSPSPAPSLEDGRRPGSRPSSQRSSS--------- Q8UUQ4_ORYLA Q8UUQ4_ORYLA SVIKGL--------------QERVPDSPSPAPSLEDSRRPGSHPSSHRSSS--------- MATCH .: . * CONSENSUS SVIK?????????????????ER???SPSP?PSLE???RP?S??SSH?SSS?????????

Q4T471_TETNG Q4T471_TETNG TSQSPSRASSSLLSSP--------------------PPPAHTPELDDETAEQQENAKKPR Q4SAZ0_TETNG Q4SAZ0_TETNG ASSSPERLGKHHNEEG--------------------EGGRCGLVSADADE---------- Q719M0_BRAFL Q719M0_BRAFL ------------------------------------------------------------ B3DJL7_DANRE B3DJL7_DANRE VPSSPTHPYTHS--------------------------PLKTAYDAHDEQRETDSALHVN Q8QHJ2_DANRE Q8QHJ2_DANRE VPSSPTHPYTHS--------------------------PLKTAYDAHDEQRETDSALHVN B3DGP5_DANRE B3DGP5_DANRE VSSSPNPHTQSPERLVL--------------------NPTDGDLPERDTGINM---KKML Q8QHJ3_DANRE Q8QHJ3_DANRE VSSSPNPHTQSPERLVL--------------------NPTDGDLPERDTGINM---KKML B1AUM0_MOUSE B1AUM0_MOUSE VSSSPSQMDHHSERMVM------------------MPNNREELIVDQDNGQSI---KKFQ B1AU60_MOUSE B1AU60_MOUSE VSSSPSQMDHHSERMVM------------------MPNNREELIVDQDNGQSI---KKFQ B1AU58_MOUSE B1AU58_MOUSE VSSSPSQMDHHSERMVM------------------MPNNREELIVDQDNGQSI---KKFQ DACH2_MOUSE DACH2_MOUSE VSSSPSQMDHHSERMVM------------------MPNNREELIVDQDNGQSI---KKFQ B1AU59_MOUSE B1AU59_MOUSE VSSSPSQMDHHSERMVM------------------MPNNREELIVDQDNGQSI---KKFQ B1AXA6_MOUSE B1AXA6_MOUSE VSSSPSQMDHHSERMVM------------------MPNNREELIVDQDNGQSI---KKFQ Q9BGY9_MACFA Q9BGY9_MACFA VSSSPSQMDHHLERME-------------------------------------------- A8K3I1_HUMAN A8K3I1_HUMAN VSSSPSQMDHHLERME-------------------------------------------- B1AJV3_HUMAN B1AJV3_HUMAN VSSSPSQMDHHLERME-------------------------------------------- Q1RMF5_HUMAN Q1RMF5_HUMAN VSSSPSQMDHHLERME-------------------------------------------- B4DQG3_HUMAN B4DQG3_HUMAN VSSSPSQMDHHLERME-------------------------------------------- A8MW17_HUMAN A8MW17_HUMAN VSSSPSQMDHHLERME-------------------------------------------- B1AJV4_HUMAN B1AJV4_HUMAN VSSSPSQMDHHLERME-------------------------------------------- DACH2_HUMAN DACH2_HUMAN VSSSPSQMDHHLERME-------------------------------------------- B4DGA6_HUMAN B4DGA6_HUMAN VSSSPSQMDHHLERME-------------------------------------------- B4DIK6_HUMAN B4DIK6_HUMAN VSSSPSQMDHHLERME-------------------------------------------- Q9PTH2_CHICK Q9PTH2_CHICK VSSSPSQLDNTPDRIAM------------------LTNSREGELIDQETGTSL---KKMQ Q5PQ18_XENLA Q5PQ18_XENLA VSSSPSQLDNIPDRVAL------------------LTNSREGEITGQDTGSIM---KKMS A4QNQ3_XENTR A4QNQ3_XENTR VSSSPSQLDNIPDRVAL------------------LPNSREGEITDQDTG---------- A8E4U6_XENTR A8E4U6_XENTR VSSSPSQLDNIPDRVAL------------------LPNSREGEITDQDTGSSM---KKML Q4RWD1_TETNG Q4RWD1_TETNG VSSSPAHTESSSDRIPIHHNGLSMNHALLGLSPNIPPGPKEGDLA-HDMSYEAATHKRIH Q1JPW1_DANRE Q1JPW1_DANRE VSSSPAHTESSSDRPHLHQNGLSLGHALLGLSPSAPPGPKEGDLATHDTVHET---KRAS Q8QHJ1_DANRE Q8QHJ1_DANRE VSSSPAHTESSSDRPHLHQNGLSLGHALLGLSPSAPPGPKEGDLATHDTVHET---KRAS B3DH35_DANRE B3DH35_DANRE VSSSPAHTESSSDRPHLHQNGLSLGHALLGLSPSAPPGPKEGDLATHDTVHET---KRAS Q0PNF7_XENTR Q0PNF7_XENTR VSSSPARTESSSDRIPVHQNGISINQMLMGLSPNIIPGPKEGDLAGHEVGHEA---KRMH Q70Q44_XENLA Q70Q44_XENLA VSSSPARTESSSDRIPVHHNGISINQMLMGLSPNIIPGPKEGDLAGHEVGHET---KRMH Q70Q63_XENLA Q70Q63_XENLA VSSSPARTESSSDRIPVHHNGISINQMLMGLSPNIIPGPKEGDLAGHEVGHET---KRMH B7ZRN2_XENLA B7ZRN2_XENLA VSSSPARTESSSDRIPVHQNGISINQMLMGLSPNIIPGPKEGDLAGHEVGHET---KRMH Q0PNF8_XENLA Q0PNF8_XENLA VSSPPARTESSSDRIPVHQNGISINQMLMGLSPNIIPGPKEGDLAGHEVGHET---KRMH Q8QHJ0_CHICK Q8QHJ0_CHICK VSSSPARTESSSDRIPVHQNGLSMNQMLMGLSPNVLPGPKEGDLAGHDMGHES---KRIH Q3UTV2_MOUSE Q3UTV2_MOUSE VSSSPARTESSSDRIPVHQNGLSMNQMLMGLSPNVLPGPKEGDLAGHDMGHES---KRIH DACH1_MOUSE DACH1_MOUSE VSSSPARTESSSDRIPVHQNGLSMNQMLMGLSPNVLPGPKEGDLAGHDMGHES---KRIH Q68G54_MOUSE Q68G54_MOUSE VSSSPARTESSSDRIPVHQNGLSMNQMLMGLSPNVLPGPKEGDLAGHDMGHES---KRIH A6NJF5_HUMAN A6NJF5_HUMAN VSSSPARTESSSDRIPVHQNGLSMNQMLMGLSPNVLPGPKEGDLAGHDMGHES---KRMH DACH1_HUMAN DACH1_HUMAN VSSSPARTESSSDRIPVHQNGLSMNQMLMGLSPNVLPGPKEGDLAGHDMGHES---KRMH A1L2G2_DANRE A1L2G2_DANRE VSSSPAHTESSSDRMPVHQNGLSMNHALLGLSPSILPGPKEGDLA-HDIVHNA---KRMH Q8UUQ4_ORYLA Q8UUQ4_ORYLA VSSSPAHTESSSDRIPIHHNGLSMNQALLGLSPNIAPGPKEGDLA-HDMSHEV---KRMH MATCH CONSENSUS VSSSP????????R??????????????????????????????????????????????

Q4T471_TETNG Q4T471_TETNG TEKD-------------------------------ESLLPLPLHKPTYEKLPLS-LSHAN Q4SAZ0_TETNG Q4SAZ0_TETNG -----------------------------------ESPL-----------------GQAL Q719M0_BRAFL Q719M0_BRAFL -----------------------------------QSLVGM------------------- B3DJL7_DANRE B3DJL7_DANRE RLSN-------------------------------DRVEQIAMKPALFEKV----PAQTF Q8QHJ2_DANRE Q8QHJ2_DANRE RLSN-------------------------------DRVEQNAVKPALFEKV----PAQTF B3DGP5_DANRE B3DGP5_DANRE KEKD-------------------------------EAQITLSMQKPGFEKLPLG--TQTL Q8QHJ3_DANRE Q8QHJ3_DANRE KEKD-------------------------------EAQITLPMQKPGFEKLPLG--TQTL B1AUM0_MOUSE B1AUM0_MOUSE RDNKE------------------------------EVPAQIPVMKSPLDKIQLA-PGQAL B1AU60_MOUSE B1AU60_MOUSE RDNKE------------------------------EVPAQIPVMKSPLDKIQLA-PGQAL B1AU58_MOUSE B1AU58_MOUSE RDNKE------------------------------EVPAQIPVMKSPLDKIQLA-PGQAL DACH2_MOUSE DACH2_MOUSE RDNKE------------------------------EVPAQIPVMKSPLDKIQLA-PGQAL B1AU59_MOUSE B1AU59_MOUSE RDNKDIQLSQHHLLNTFLHWIELAPLSKKSLHHQKEVPAQIPVMKSPLDKIQLA-PGQAL B1AXA6_MOUSE B1AXA6_MOUSE RDNKDIQLSQHHLLNTFLHWIELAPLSKKSLHHQKEVPAQIPVMKSPLDKIQLA-PGQAL Q9BGY9_MACFA Q9BGY9_MACFA -----------------------------------EVPVQIPIMKSPLDKIQLT-PGQAL A8K3I1_HUMAN A8K3I1_HUMAN -----------------------------------EVPVQIPIMKSPLDKIQLT-PGQAL B1AJV3_HUMAN B1AJV3_HUMAN -----------------------------------EVPVQIPIMKSPLDKIQLT-PGQAL Q1RMF5_HUMAN Q1RMF5_HUMAN -----------------------------------EVPVQIPIMKSPLDKIQLT-PGQAL B4DQG3_HUMAN B4DQG3_HUMAN -----------------------------------EVPVQIPIMKSPLDKIQLT-PGQAL A8MW17_HUMAN A8MW17_HUMAN -----------------------------------EVPVQIPIMKSPLDKIQLT-PGQAL B1AJV4_HUMAN B1AJV4_HUMAN -----------------------------------EVPVQIPIMKSPLDKIQLT-PGQAL DACH2_HUMAN DACH2_HUMAN -----------------------------------EVPVQIPIMKSPLDKIQLT-PGQAL B4DGA6_HUMAN B4DGA6_HUMAN -----------------------------------EVPVQIPIMKSPLDKIQLT-PGQAL B4DIK6_HUMAN B4DIK6_HUMAN -----------------------------------EVPVQIPIMKSPLDKIQLT-PGQAL Q9PTH2_CHICK Q9PTH2_CHICK KEKE-------------------------------EVQIAIPIMKPTLDKVQLA--GQAL Q5PQ18_XENLA Q5PQ18_XENLA KEKD-------------------------------DIQIAIPFIKPTLDKVQLT--GQTL A4QNQ3_XENTR A4QNQ3_XENTR ------------------------------------------------------------ A8E4U6_XENTR A8E4U6_XENTR KEKD-------------------------------EIQIAIPIMKPTLDKVQLA--GQTL Q4RWD1_TETNG Q4RWD1_TETNG AD---------------------------------------------------------- Q1JPW1_DANRE Q1JPW1_DANRE TEEE-------------------------------ENVLCTPTSRDSYERLSHS--GPTL Q8QHJ1_DANRE Q8QHJ1_DANRE TEKE-------------------------------ENVLCTPTSRDTYERLSHS--GPTL B3DH35_DANRE B3DH35_DANRE TEKE-------------------------------ENVLCTPTSRDTYERLSHS--GPTL Q0PNF7_XENTR Q0PNF7_XENTR MEKD-------------------------------ETPLSTPTARDSFDKLSLSGHGQHL Q70Q44_XENLA Q70Q44_XENLA MEKD-------------------------------ETLLSTPTARDSFDRHSLSGHGQPL Q70Q63_XENLA Q70Q63_XENLA MEKD-------------------------------ETLLSTPTARDSFDRHSLSGHGQPL B7ZRN2_XENLA B7ZRN2_XENLA LEKD-------------------------------ETLLSTPTARDSFDKLSLCGHGQPL Q0PNF8_XENLA Q0PNF8_XENLA LEKD-------------------------------ETLLSTPTARDSFDKLSLCGHGQPL Q8QHJ0_CHICK Q8QHJ0_CHICK IEKD-------------------------------ETPLSTPTARDSLDKLSLTGHGQPL Q3UTV2_MOUSE Q3UTV2_MOUSE IEKD-------------------------------ETPLSTPTARDSIDKLSLTGHGQPL DACH1_MOUSE DACH1_MOUSE IEKD-------------------------------ETPLSTPTARDSIDKLSLTGHGQPL Q68G54_MOUSE Q68G54_MOUSE IEKD-------------------------------ETPLSTPTARDSIDKLSLTGHGQPL A6NJF5_HUMAN A6NJF5_HUMAN IEKD-------------------------------ETPLSTPTARDSLDKLSLTGHGQPL DACH1_HUMAN DACH1_HUMAN IEKD-------------------------------ETPLSTPTARDSLDKLSLTGHGQPL A1L2G2_DANRE A1L2G2_DANRE LEKE-------------------------------ETPMCTPTARDSYERLSLA--GQTL Q8UUQ4_ORYLA Q8UUQ4_ORYLA ADKE-------------------------------DNPMCTPTARDSYERLSLA--GQAL MATCH CONSENSUS ???????????????????????????????????E?????P??????????????GQ?L

Q4T471_TETNG Q4T471_TETNG PA--LAPFLLAEGLSSMETLLTNIQ---------------------GLLKVAVQSARCQD Q4SAZ0_TETNG Q4SAZ0_TETNG PPGFPAPFLFADGLSSVETLLTNIQVRSPATIWSFLGNQLTGRLLQGLLKVAVENARVQD Q719M0_BRAFL Q719M0_BRAFL -----APFL-PENISSTETLLTNIQ---------------------GLLKVAADNARQQE B3DJL7_DANRE B3DJL7_DANRE PSGFPASLLFTDGLSSVETLLTNVQ---------------------GLLKVALENARLQE Q8QHJ2_DANRE Q8QHJ2_DANRE PSGFPASLLFTDGLSSVETLLTNVQ---------------------GLLKVALENARLQE B3DGP5_DANRE B3DGP5_DANRE PPGFPAPFLFADGLSSVETLLTNIQ---------------------GLLKVAVDNARVQE Q8QHJ3_DANRE Q8QHJ3_DANRE PPGFPAPFLFADGLSSVETLLTNIQ---------------------GLLKVAVDNARVQE B1AUM0_MOUSE B1AUM0_MOUSE HPGFPGPFIFADSLSSVETLLTNIQ---------------------GLLKVALDNARIQE B1AU60_MOUSE B1AU60_MOUSE HPGFPGPFIFADSLSSVETLLTNIQ---------------------GLLKVALDNARIQE B1AU58_MOUSE B1AU58_MOUSE HPGFPGPFIFADSLSSVETLLTNIQ---------------------GLLKVALDNARIQE DACH2_MOUSE DACH2_MOUSE HPGFPGPFIFADSLSSVETLLTNIQ---------------------GLLKVALDNARIQE B1AU59_MOUSE B1AU59_MOUSE HPGFPGPFIFADSLSSVETLLTNIQV-----------NNISINKINGLLKVALDNARIQE B1AXA6_MOUSE B1AXA6_MOUSE HPGFPGPFIFADSLSSVETLLTNIQV-----------NNISINKINGLLKVALDNARIQE Q9BGY9_MACFA Q9BGY9_MACFA PAGFPGPFIFADSLSSVETLLTNIQ---------------------GLLKVALDNARIQE A8K3I1_HUMAN A8K3I1_HUMAN PAGFPGPFIFADSLSSVETLLTNIQ---------------------GLLKVALDNARIQE B1AJV3_HUMAN B1AJV3_HUMAN PAGFPGPFIFADSLSSVETLLTNIQ---------------------GLLKVALDNARIQE Q1RMF5_HUMAN Q1RMF5_HUMAN PAGFPGPFIFADSLSSVETLLTNIQ---------------------GLLKVALDNARIQE B4DQG3_HUMAN B4DQG3_HUMAN PAGFPGPFIFADSLSSVETLLTNIQ---------------------GLLKVALDNARIQE A8MW17_HUMAN A8MW17_HUMAN PAGFPGPFIFADSLSSVETLLTNIQ---------------------GLLKVALDNARIQE B1AJV4_HUMAN B1AJV4_HUMAN PAGFPGPFIFADSLSSVETLLTNIQ---------------------GLLKVALDNARIQE DACH2_HUMAN DACH2_HUMAN PAGFPGPFIFADSLSSVETLLTNIQ---------------------GLLKVALDNARIQE B4DGA6_HUMAN B4DGA6_HUMAN PAGFPGPFIFADSLSSVETLLTNIQV-----------NNISINKINGLLKVALDNARIQE B4DIK6_HUMAN B4DIK6_HUMAN PAGFPGPFIFADSLSSVETLLTNIQ---------------------GLLKVALDNARIQE Q9PTH2_CHICK Q9PTH2_CHICK PPGFPAPFLFADGLSSVETLLTNIQ---------------------GLLKVAVDNARVQE Q5PQ18_XENLA Q5PQ18_XENLA PPGFPSPFLFADGLSSVETLLTNIQ---------------------GLLKVAVDNARVQE A4QNQ3_XENTR A4QNQ3_XENTR ------------------------------------------------------------ A8E4U6_XENTR A8E4U6_XENTR PPGFPSPFLFADGLSSVETLLTNIQ---------------------GLLKVAVDNARVQE Q4RWD1_TETNG Q4RWD1_TETNG -------------------------------------------------KVAIDNARAQE Q1JPW1_DANRE Q1JPW1_DANRE PPGFPAPLLFPEGLSSIETLLTNIQ---------------------GLLKVAIDNARAQE Q8QHJ1_DANRE Q8QHJ1_DANRE PPGFPAPLLFPEGLSSIETLLTNIQ---------------------GLLKVAIDNARAQE B3DH35_DANRE B3DH35_DANRE PPGFPAPLLFPEGLSSIETLLTNIQ---------------------GLLKVAIDNARAQE Q0PNF7_XENTR Q0PNF7_XENTR PPGYPSPFLFPDGLSSIETLLTNIQ---------------------GLLKVAIDNARAQE Q70Q44_XENLA Q70Q44_XENLA PPGYPSPFLFP----GWDCLL--------------------------------------- Q70Q63_XENLA Q70Q63_XENLA PPGYPSPFLFP----GWDCLL--------------------------------------- B7ZRN2_XENLA B7ZRN2_XENLA PPGYPSPFLFPDGLSSIETLLTNIQ---------------------GLLKVAIDNARAQE Q0PNF8_XENLA Q0PNF8_XENLA PPGYPSPFLFPDGLSSIETLLTNIQ---------------------GLLKVAIDNARAQE Q8QHJ0_CHICK Q8QHJ0_CHICK PPGFPSPFLFPDGLSSIETLLTNIQ---------------------GLLKVAIDNARAQE Q3UTV2_MOUSE Q3UTV2_MOUSE PPGFPSPFLFPDGLSSIETLLTNIQ---------------------GLLKVAIDNARAQE DACH1_MOUSE DACH1_MOUSE PPGFPSPFLFPDGLSSIETLLTNIQ---------------------GLLKVAIDNARAQE Q68G54_MOUSE Q68G54_MOUSE PPGFPSPFLFPDGLSSIETLLTNIQ---------------------GLLKVAIDNARAQE A6NJF5_HUMAN A6NJF5_HUMAN PPGFPSPFLFPDGLSSIETLLTNIQ---------------------GLLKVAIDNARAQE DACH1_HUMAN DACH1_HUMAN PPGFPSPFLFPDGLSSIETLLTNIQ---------------------GLLKVAIDNARAQE A1L2G2_DANRE A1L2G2_DANRE PPGSPSPFLFPDGLSSIETLLTNIQ---------------------GLLKVAIDNARAQE Q8UUQ4_ORYLA Q8UUQ4_ORYLA PPGFPSPFLFPDGLSSIETLLTNIQ---------------------GLLKVAIDNARAQE MATCH CONSENSUS ??G?P?PF?F???LSS?ETLLTNIQ?????????????????????GLLKVA?DNAR?QE

Q4T471_TETNG Q4T471_TETNG KQNQMERKELKVELDKERDARQTLQRQLSSELQTRASIQKRLKKEKKAKRRLQEALDFES Q4SAZ0_TETNG Q4SAZ0_TETNG KQIQAEKRELKMELYREREMRESLERQLTSELQSRDSAAAEEKPEINGNQQDNGAV---- Q719M0_BRAFL Q719M0_BRAFL KQVTMEKAELKMELLRERELREALEKQLGEEQRSRAVLQKRLKKGKKAKRKMLEQLEQEQ B3DJL7_DANRE B3DJL7_DANRE KQLQQERRELKMELYREREMRESLERQLTSELRTRATIQRRLKKEKKAKRRLQEALEYES Q8QHJ2_DANRE Q8QHJ2_DANRE KQLQQERRELKMELYREREMRESLERQLTSELRTRATIQRRLKKEKKAKRRLQEALEYES B3DGP5_DANRE B3DGP5_DANRE KQVQQERKELKMELYREREMRESLERQLTSELHSRATIQKRLKKEKKAKRKLQEALEFES Q8QHJ3_DANRE Q8QHJ3_DANRE KQVQQERKELKMELYREREMRESLERQLTSELHSRATIQKRLKKGKKAKRKLQEALEFES B1AUM0_MOUSE B1AUM0_MOUSE KQIQQEKKELRIELFREREIRENLERQLAVELQSRSTMQKRLKKEKKAKRKLQEALEFES B1AU60_MOUSE B1AU60_MOUSE KQIQQEKKELRIELFREREIRENLERQLAVELQSRSTMQKRLKKEKKAKRKLQEALEFES B1AU58_MOUSE B1AU58_MOUSE KQIQQEKKELRIELFREREIRENLERQLAVELQSRSTMQKRLKKEKKAKRKLQEALEFES DACH2_MOUSE DACH2_MOUSE KQIQQEKKELRIELFREREIRENLERQLAVELQSRSTMQKRLKKEKKAKRKLQEALEFES B1AU59_MOUSE B1AU59_MOUSE KQIQQEKKELRIELFREREIRENLERQLAVELQSRSTMQKRLKKEKKAKRKLQEALEFES B1AXA6_MOUSE B1AXA6_MOUSE KQIQQEKKELRIELFREREIRENLERQLAVELQSRSTMQKRLKKEKKAKRKLQEALEFES Q9BGY9_MACFA Q9BGY9_MACFA KQIQQEKKELRLELYREREIRENLERQLAVELQSRTTMQKRLKKEKKNKRKLQEALEFES A8K3I1_HUMAN A8K3I1_HUMAN KQIQQEKKELRLELYREREIRENLERQLAVELQSRTTMQKRLKKEKKTKRKLQEALEFES B1AJV3_HUMAN B1AJV3_HUMAN KQIQQEKKELRLELYREREIRENLERQLAVELQSRTTMQKRLKKEKKTKRKLQEALEFES Q1RMF5_HUMAN Q1RMF5_HUMAN KQIQQEKKELRLELYREREIRENLERQLAVELQSRTTMQKRLKKEKKTKRKLQEALEFES B4DQG3_HUMAN B4DQG3_HUMAN KQIQQEKKELRLELYREREIRENLERQLAVELQSRTTMQKRLKKEKKTKRKLQEALEFES A8MW17_HUMAN A8MW17_HUMAN KQIQQEKKELRLELYREREIRENLERQLAVELQSRTTMQKRLKKEKKTKRKLQEALEFES B1AJV4_HUMAN B1AJV4_HUMAN KQIQQEKKELRLELYREREIRENLERQLAVELQSRTTMQKRLKKEKKTKRKLQEALEFES DACH2_HUMAN DACH2_HUMAN KQIQQEKKELRLELYREREIRENLERQLAVELQSRTTMQKRLKKEKKTKRKLQEALEFES B4DGA6_HUMAN B4DGA6_HUMAN KQIQQEKKELRLELYREREIRENLERQLAVELQSRSTMQKRLKKEKKTKRKLQEALEFES B4DIK6_HUMAN B4DIK6_HUMAN KQIQQEKKELRLELYREREIRENLERQLAVELQSRTTMQKRLKKEKKTKRKLQEALEFES Q9PTH2_CHICK Q9PTH2_CHICK KQIQQEKKELKMELCRERELRESLERQLTAELQSRATIQKRLKKEKKAKRKLQEALEFES Q5PQ18_XENLA Q5PQ18_XENLA KQIQQEKKELKLELCRERELRENLERQLTAELQSRATIQKRLKKEKKAKRKLQDALEFES A4QNQ3_XENTR A4QNQ3_XENTR -----------------------------------SSMKKMLKKKKK------------- A8E4U6_XENTR A8E4U6_XENTR KQIQQEKKELKMELCRERELRENLERQLTAELQSRATIQKRLKKEKKAKRKLQEALEFES Q4RWD1_TETNG Q4RWD1_TETNG KQVQLEKTELKMELFRERELRETLEKQLAMEQKNRAIIQKRLKKEKKAKRKLQEALEYES Q1JPW1_DANRE Q1JPW1_DANRE KQVQLERTELKMELYRERELRETLERQLCVEQKNRALIQKRLKKEKKTKRKLQEALEVES Q8QHJ1_DANRE Q8QHJ1_DANRE KQVQLERTELKMELYRERELRETLERQLCVEQKNRALIQKRLKKEKKTKRKLQEALEVES B3DH35_DANRE B3DH35_DANRE KQVQLERTELKMELYRERELRETLERQLCVEQKNRALIQKRLKKEKKTKRKLQEALEVES Q0PNF7_XENTR Q0PNF7_XENTR KQVQMEKTELKMELFRERELRETLEKQLAVEQKNRAIIQKRLKKEKKAKRKLQEALEFET Q70Q44_XENLA Q70Q44_XENLA ------------------------------------------------------------ Q70Q63_XENLA Q70Q63_XENLA ------------------------------------------------------------ B7ZRN2_XENLA B7ZRN2_XENLA KQVQMEKTELKMELFRERELREAIEKQFAVEQKNRAIIQKRLKKEKKAKRKLQEALEFET Q0PNF8_XENLA Q0PNF8_XENLA KQVQMEKTELKMELFRERELREAIEKQFAVEQKNRAIIQKRLKKEKKAKRKLQEALEFET Q8QHJ0_CHICK Q8QHJ0_CHICK KQVQLEKTELKMELFRERELRETLEKQLAVEQKNRAIIQKRLKKEKKAKRKLQEALEFET Q3UTV2_MOUSE Q3UTV2_MOUSE KQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEALEFET DACH1_MOUSE DACH1_MOUSE KQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEALEFET Q68G54_MOUSE Q68G54_MOUSE KQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEALEFET A6NJF5_HUMAN A6NJF5_HUMAN KQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEALEFET DACH1_HUMAN DACH1_HUMAN KQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEALEFET A1L2G2_DANRE A1L2G2_DANRE KQVQLEKTELKMELFRERELRETLEKQLAVEQKNRAIIQKRLKKEKKAKRKLQEALEYES Q8UUQ4_ORYLA Q8UUQ4_ORYLA KQVQLEKTELKMELFRERELRETLEKQLAVEQKNRAIIQKRLKKEKKAKRKLQEALEYES MATCH CONSENSUS KQ?Q?E??EL??EL?RERE?RE?LE?QL??E???R???QKRLKKEKK?KRKLQEALE?E?

Q4T471_TETNG Q4T471_TETNG RRREQVERALKHSD---------------------------------------------- Q4SAZ0_TETNG Q4SAZ0_TETNG -----------QGTPAKPKPRT---------YTRSHTHTHTDKNTPRTFAGVF------- Q719M0_BRAFL Q719M0_BRAFL RRRIQAEDGVKQTSSD--SLRV-LNESLSQELEVERN-ARTDAERKLQ-DARLYFKNSVL B3DJL7_DANRE B3DJL7_DANRE KRRGQIEQALQQATSSD-SL---THDPISLEMETEQCRSPEDNC-LLQ-ESRTYTKNPII Q8QHJ2_DANRE Q8QHJ2_DANRE KRRGQIEQALQQATSSD-SL---THDPISLEMETERCRSPEDNC-LLQ-ESRTYTKNPII B3DGP5_DANRE B3DGP5_DANRE KRREQVEQALKQATSPE-SLRMSLNDAVIPEVKSEHNGNQQENS-SVQ-ENRPYSKPPIM Q8QHJ3_DANRE Q8QHJ3_DANRE KRREQVEQALKQATSPE-SLRLSLNEAIIPEGESEHNGNQQENS-SVQ-ENRPYSKPPIM B1AUM0_MOUSE B1AUM0_MOUSE KRREQVEQALKQATSGDSGLRM-LKDSGIPDIEIENSGTPHDSA-AMQ-A---------- B1AU60_MOUSE B1AU60_MOUSE KRREQVEQALKQATSGDSGLRM-LKDSGIPDIEIENSGTPHDSA-AMQ-A---------- B1AU58_MOUSE B1AU58_MOUSE KRREQVEQALKQATSGDSGLRM-LKDSGIPDIEIENSGTPHDSA-AMQ-GGNYYCLAMAQ DACH2_MOUSE DACH2_MOUSE KRREQVEQALKQATSGDSGLRM-LKDSGIPDIEIENSGTPHDSA-AMQ-GGNYYCLAMAQ B1AU59_MOUSE B1AU59_MOUSE KRREQVEQALKQATSGDSGLRM-LKDSGIPDIEIENSGTPHDSA-AMQ-GGNYYCLAMAQ B1AXA6_MOUSE B1AXA6_MOUSE KRREQVEQALKQATSGDSGLRM-LKDSGIPDIEIENSGTPHDSA-AMQ-GGNYYCLAMAQ Q9BGY9_MACFA Q9BGY9_MACFA KRREQVEQALKQATTSDSGLRM-LKDT--------------------------------- A8K3I1_HUMAN A8K3I1_HUMAN KRREQVEQALKQATTSDSGLRM-LKDTGIPDIEIENNGTPHDSA-AMQ-GGNYYCLEMAQ B1AJV3_HUMAN B1AJV3_HUMAN KRREQVEQALKQATTSDSGLRM-LKDTGIPDIEIENNGTPHDSA-AMQ-A---------- Q1RMF5_HUMAN Q1RMF5_HUMAN KRREQVEQALKQATTSDSGLRM-LKDTGIPDIEIENNGTPHDSA-AMQ-GGNYYCLEMAQ B4DQG3_HUMAN B4DQG3_HUMAN KRREQVEQALKQATTSDSGLRM-LKDTGIPDIEIENNGTPHDSA-AMQ-GGNYYCLEMAQ A8MW17_HUMAN A8MW17_HUMAN KRREQVEQALKQATTSDSGLRM-LKDTGIPDIEIENNGTPHDSA-AMQ-GGNYYCLEMAQ B1AJV4_HUMAN B1AJV4_HUMAN KRREQVEQALKQATTSDSGLRM-LKDTGIPDIEIENNGTPHDSA-AMQ-GGNYYCLEMAQ DACH2_HUMAN DACH2_HUMAN KRREQVEQALKQATTSDSGLRM-LKDTGIPDIEIENNGTPHDSA-AMQ-GGNYYCLEMAQ B4DGA6_HUMAN B4DGA6_HUMAN KRREQVEQALKQATTSDSGLRM-LKDTGIPDIEIENNGTPHDSA-AMQ-A---------- B4DIK6_HUMAN B4DIK6_HUMAN KRREQVEQALKQATTSDSGLRM-LKDTGIPDIEIENNGTPHDSA-AMQ-A---------- Q9PTH2_CHICK Q9PTH2_CHICK KRREQVEQALKQATSGD-GLRM-LNDAGIPDMEIEHNGTQHDSA-AMQ-ENRTYIKPTIM Q5PQ18_XENLA Q5PQ18_XENLA KRREQVEQALKQATSGE-GLRM-LNDACIPEMETEHNGSQHDSP-PMQ-ENRTYIKPPIM A4QNQ3_XENTR A4QNQ3_XENTR ------------------------------------------------------------ A8E4U6_XENTR A8E4U6_XENTR KRREQVEQALKQATSGE-GLRM-LNDACIPEMETEHNGSQHDSP-PMQ-ENRTYIKPPIM Q4RWD1_TETNG Q4RWD1_TETNG KRREQVEQTLKQPSPSD-SMRS-LNDSLTPEMESDRSTGRTDAERTIQ-GPLEMTPDAVM Q1JPW1_DANRE Q1JPW1_DANRE KRRDHAEQTLQRTTSCE-RSPI-HNDS-QQELETIHNTSKTDTERTIQ-DGRLFLKSTMM Q8QHJ1_DANRE Q8QHJ1_DANRE KRRDLHEQTLQRTTSCE-RSPI-HNDS-QQELETILITSKTDTEGTIQ-DGRLFLKSTMM B3DH35_DANRE B3DH35_DANRE KRRDHAEQTLQRTTSCE-RSPI-HNDS-QQELETIHNTSKTDTERTIQ-DGRLFLKSTMM Q0PNF7_XENTR Q0PNF7_XENTR KRREQAEQALKQAASSE-GLRV-LNESLTPDLETDRNGARTDAERTIQ-DGRLYLKSSVM Q70Q44_XENLA Q70Q44_XENLA ------------------------------------------------------------ Q70Q63_XENLA Q70Q63_XENLA ------------------------------------------------------------ B7ZRN2_XENLA B7ZRN2_XENLA KRREQAEQALKQAASSE-GLRV-LNESMTPDLETDRNGARTDAERTIQ-DGRLYLKTSVM Q0PNF8_XENLA Q0PNF8_XENLA KRREQAEQALKQAASSE-GLRV-LNESMTPDLETDRNGARTDAERTIQ-DGRLYLKTSVM Q8QHJ0_CHICK Q8QHJ0_CHICK KRREQAEQTLKQAASTD-SLRV-LNDSLTPEIEADRSGGRTDAERTIQGSLDAYA----- Q3UTV2_MOUSE Q3UTV2_MOUSE KRREQAEQTLKQAASAD-SLRV-LNDSLTPEIEG-------------------------- DACH1_MOUSE DACH1_MOUSE KRREQAEQTLKQAASAD-SLRV-LNDSLTPEIEADRSGGRADAERTIQ-DGRLYLKTTVM Q68G54_MOUSE Q68G54_MOUSE KRREQAEQTLKQAASAD-SLRV-LNDSLTPEIEADRSGGRADAERTIQ-DGRLYLKTTVM A6NJF5_HUMAN A6NJF5_HUMAN KRREQAEQTLKQAASTD-SLRV-LNDSLTPEIEADRSGGRTDAERTIQ-AARLYIKTVCM DACH1_HUMAN DACH1_HUMAN KRREQAEQTLKQAASTD-SLRV-LNDSLTPEIEADRSGGRTDAERTIQ-DGRLYLKTTVM A1L2G2_DANRE A1L2G2_DANRE KRREQAEQTLKQTSPTE-SLRS-LNDSLTQEIETDRSSGRTDAERTIQADGRLFLKTTVM Q8UUQ4_ORYLA Q8UUQ4_ORYLA KRREQAEQTLKQPSPSD-SMRS-LNDSLTPEMESDRSSGRTDAERTIQ-DGRLFLKTTVM MATCH CONSENSUS KRR?Q?EQ?L?Q????????????????????E????????D?????Q????????????

Q4T471_TETNG Q4T471_TETNG ------------------------------------------------ Q4SAZ0_TETNG Q4SAZ0_TETNG ------------------------------------------------ Q719M0_BRAFL Q719M0_BRAFL FNA--------------------------------------------- B3DJL7_DANRE B3DJL7_DANRE Y----------------------------------------------- Q8QHJ2_DANRE Q8QHJ2_DANRE Y----------------------------------------------- B3DGP5_DANRE B3DGP5_DANRE Y----------------------------------------------- Q8QHJ3_DANRE Q8QHJ3_DANRE Y----------------------------------------------- B1AUM0_MOUSE B1AUM0_MOUSE ------------------------------------------------ B1AU60_MOUSE B1AU60_MOUSE ------------------------------------------------ B1AU58_MOUSE B1AU58_MOUSE QLCSA------------------------------------------- DACH2_MOUSE DACH2_MOUSE QLCSA------------------------------------------- B1AU59_MOUSE B1AU59_MOUSE QLCSA------------------------------------------- B1AXA6_MOUSE B1AXA6_MOUSE QLCSA------------------------------------------- Q9BGY9_MACFA Q9BGY9_MACFA ------------------------------------------------ A8K3I1_HUMAN A8K3I1_HUMAN QLYSA------------------------------------------- B1AJV3_HUMAN B1AJV3_HUMAN ------------------------------------------------ Q1RMF5_HUMAN Q1RMF5_HUMAN QLYSA------------------------------------------- B4DQG3_HUMAN B4DQG3_HUMAN QLYSA------------------------------------------- A8MW17_HUMAN A8MW17_HUMAN QLYSA------------------------------------------- B1AJV4_HUMAN B1AJV4_HUMAN QLYSA------------------------------------------- DACH2_HUMAN DACH2_HUMAN QLYSA------------------------------------------- B4DGA6_HUMAN B4DGA6_HUMAN ------------------------------------------------ B4DIK6_HUMAN B4DIK6_HUMAN ------------------------------------------------ Q9PTH2_CHICK Q9PTH2_CHICK Y----------------------------------------------- Q5PQ18_XENLA Q5PQ18_XENLA Y----------------------------------------------- A4QNQ3_XENTR A4QNQ3_XENTR ------------------------------------------------ A8E4U6_XENTR A8E4U6_XENTR Y----------------------------------------------- Q4RWD1_TETNG Q4RWD1_TETNG SDKYVNKFLELKMPRRDASFNVNIVVQKGLRTRWREVEAEPDVIHAGL Q1JPW1_DANRE Q1JPW1_DANRE Y----------------------------------------------- Q8QHJ1_DANRE Q8QHJ1_DANRE Y----------------------------------------------- B3DH35_DANRE B3DH35_DANRE Y----------------------------------------------- Q0PNF7_XENTR Q0PNF7_XENTR Y----------------------------------------------- Q70Q44_XENLA Q70Q44_XENLA ------------------------------------------------ Q70Q63_XENLA Q70Q63_XENLA ------------------------------------------------ B7ZRN2_XENLA B7ZRN2_XENLA Y----------------------------------------------- Q0PNF8_XENLA Q0PNF8_XENLA Y----------------------------------------------- Q8QHJ0_CHICK Q8QHJ0_CHICK ------------------------------------------------ Q3UTV2_MOUSE Q3UTV2_MOUSE ------------------------------------------------ DACH1_MOUSE DACH1_MOUSE Y----------------------------------------------- Q68G54_MOUSE Q68G54_MOUSE Y----------------------------------------------- A6NJF5_HUMAN A6NJF5_HUMAN Y----------------------------------------------- DACH1_HUMAN DACH1_HUMAN Y----------------------------------------------- A1L2G2_DANRE A1L2G2_DANRE Y----------------------------------------------- Q8UUQ4_ORYLA Q8UUQ4_ORYLA Y----------------------------------------------- MATCH CONSENSUS ????????????????????????????????????????????????


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