Alignment of the gene Family HBG065925 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
Q4RLC3_TETNG Q4RLC3_TETNG ------------------------------------------------------------ A0JM06_XENTR A0JM06_XENTR ERYNQVKVLLKNWETAFLQEHKRRPNKTDVENASNETQELYKEYRSLKQGQLDVSTESVF B1WBC8_XENLA B1WBC8_XENLA ECYNEVKVLLKKWETAFLQEHKRKPNKTDVESASNETQELYKKFKSLKKEQLDISTDTVF Q33DM4_XENLA Q33DM4_XENLA ERYNEVKVLLKKWETAFLQEHKRKPNKTDVESASNETQELYKEFKSLKKEQLDISTDTVF Q4JNX8_XENLA Q4JNX8_XENLA ERYNEVKVLLKKWETAFLQEHKRKPNKTDVESASNETQELYKEFKSLKKEQLDISTDTVF A3KMF3_MOUSE A3KMF3_MOUSE -RLATVRARLQEWERAFARLHGRRPAKGDVEAAPEETRALYREYRNLKQA---------- RECQ4_MOUSE RECQ4_MOUSE ERLATVRARLQEWERAFARLHGRRPAKGDVEAAPEETRALYREYRNLKQA---------- A5D786_BOVIN A5D786_BOVIN ERLRDVRELLQAWERAFRRQSGRRPGKEDVEAAPEETRALYREYRSLKKA---------- RECQ4_HUMAN RECQ4_HUMAN ERLRDVRERLQAWERAFRRQRGRRPSQDDVEAAPEETRALYREYRTLKRT---------- MATCH CONSENSUS ?????V???L??WE?AF?????R?P???DVE?A??ET??LY?????LK????????????

Q4RLC3_TETNG Q4RLC3_TETNG ------------------------------------------------------------ A0JM06_XENTR A0JM06_XENTR TPKSGQV--ASPRLARSADAAGDSEGSASWGSHLNRACVTPKLTPKERDSLKASAQFYGM B1WBC8_XENLA B1WBC8_XENLA TPKSGQVMETSPKPTHRADAAGDSEGSASWGIHLNRASVTPKLTSKERDSLKASAQFYGM Q33DM4_XENLA Q33DM4_XENLA TPKSGQVMETSPKPTHRADAAGDSEGSASWGIHLNRASVTPKLTSKERDSLKASAQFYGM Q4JNX8_XENLA Q4JNX8_XENLA TPKSGQVMETSPKPTHRADAAGDSEGSASWGIHLNRASVTPKLTSKERDSLKASAQFYGM A3KMF3_MOUSE A3KMF3_MOUSE VRQADD--RHRVLEQSLAEAAEEAQEPSCWGPHLSRAA-TQNTQSMPKQSLLSSVQDYGK RECQ4_MOUSE RECQ4_MOUSE VRQADD--RHRVLEQSLAEAAEEAQEPSCWGPHLSRAA-TQNTQSMPKQSLLSSVQDYGK A5D786_BOVIN A5D786_BOVIN LGQAGGVEPHGS-GQSLPVAAEQMLEPSCWGHHLNRAA-TQSPHPPSRWSPQESAQDYGK RECQ4_HUMAN RECQ4_HUMAN TGQAGGGLRSS---ESLPAAAEEAPEPRCWGPHLNRAA-TKSPQPTPGRSRQGSVPDYGQ MATCH CONSENSUS ???????????????????AA????????WG?HL?RA??T?????????S???S???YG?

Q4RLC3_TETNG Q4RLC3_TETNG ------------------------------------------------------------ A0JM06_XENTR A0JM06_XENTR KLKANLGGASKERPVSLKKSFTPRSRPAIGSPDVKTRNHLAFPKPPGTPISPPELLQDTP B1WBC8_XENLA B1WBC8_XENLA KLKANLGGALREHPVSLKKSFTPRFRP-LDSPDVKIKNNLASPKSLDTPSSPLALLQDPP Q33DM4_XENLA Q33DM4_XENLA KLKANLGGALREHPVSLKKSFTPRFRP-LDSPDVKIKNNLASPKSLDTPSSPLALLQDPP Q4JNX8_XENLA Q4JNX8_XENLA KLKANLGGALREHPVSLKKSFTPRFRP-LDSPDVKIKNNLASPKSLDTPSSPLALLQDPP A3KMF3_MOUSE A3KMF3_MOUSE RLKANLKNTTQTGPTQSRKLQ----------LQKRSLSTVPAPRPPGSKTESPC-----P RECQ4_MOUSE RECQ4_MOUSE RLKANLKNTTQTGPTQSRKLQ----------LQKRSLSTVPAPRPPGSKTESPC-----P A5D786_BOVIN A5D786_BOVIN RLKANLKGSLQARSTLGRIPR----------LAQRSSSKIPSPEPSGTAAAPIS-----P RECQ4_HUMAN RECQ4_HUMAN RLKANLKGTLQAGPALGRRPW----------PLGRASSKASTPKPPGTGPVPSF-----A MATCH CONSENSUS ?LKANL????????????????????????????????????P?????????????????

Q4RLC3_TETNG Q4RLC3_TETNG ------------------------------------------------------------ A0JM06_XENTR A0JM06_XENTR SEPSDTSSHISLKEPPPKPAWNPSALGQPIKKQHQLQAMVGQRMASLNQEWLQRCELRNG B1WBC8_XENLA B1WBC8_XENLA SEPLDTLSHVSLKEPPHKPVMNPPTQGQPIKKQHQLQAMVGQRMASLNQEWLQRCELRNG Q33DM4_XENLA Q33DM4_XENLA SEPFDTLSHVSLKEPPHKPVMNPPTQGQPIKKQHQLQAMVGQRMASLNQEWLQRCELRNG Q4JNX8_XENLA Q4JNX8_XENLA SEPFDTLSHVSLKEPPHKPVMNPPTQGQPIKKQHQLQAMVGQRMASLNQEWLQRCELRNG A3KMF3_MOUSE A3KMF3_MOUSE DEADDALPRVP--EPRPRLG-----------QLQQLRSSLSRRLTSLDPGWLERC----- RECQ4_MOUSE RECQ4_MOUSE DEADDALPRVP--EPRPRLG-----------QLQQLRSSLSRRLTSLDPGWLERC----- A5D786_BOVIN A5D786_BOVIN ENVNEVLPQPP--RPQLRPG-----------RLQQLRASLSLRLGSLDPDWLQRC----- RECQ4_HUMAN RECQ4_HUMAN EKVSDEPPQLP--EPQPRPG-----------RLQHLQASLSQRLGSLDPGWLQRC----- MATCH CONSENSUS ??????????????P????????????????????L??????R??SL???WL?RC?????

Q4RLC3_TETNG Q4RLC3_TETNG ------------------------------------------------------------ A0JM06_XENTR A0JM06_XENTR AEPMEVTAAEQRNVNREQCDSTWEPLAEGAIES--TDLHITSNNDEFAHS----VTSPTH B1WBC8_XENLA B1WBC8_XENLA VEAMEVTAAEQRTVNRQQCNTMREALGEGAIGGPFTDLQFSSNNDELTHSTQHTVASPKQ Q33DM4_XENLA Q33DM4_XENLA VEAMEVTAAEQRTVNRQQCNTMREALGEGAIEENCKSVKGPPNNDELTHSTQHTVASPKQ Q4JNX8_XENLA Q4JNX8_XENLA VEAMEVTAAEQRTVNRQQCNTMREALGEGAIEENCKSVKGPPNNDELTHSTQHTVASPKQ A3KMF3_MOUSE A3KMF3_MOUSE ------------------------------------------------------------ RECQ4_MOUSE RECQ4_MOUSE ------------------------------------------------------------ A5D786_BOVIN A5D786_BOVIN ------------------------------------------------------------ RECQ4_HUMAN RECQ4_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4RLC3_TETNG Q4RLC3_TETNG ------------------------------------------------------------ A0JM06_XENTR A0JM06_XENTR SVLAFTPGPSQHAASPSLPLTFGRLDKSPEKPKQKAVETP--GRNSIVRSRVTDSVSSRN B1WBC8_XENLA B1WBC8_XENLA KVQAYTPVFSPHAAAPSLPLTFGRQDTRPENPKLKAEEISDFGRSSSVRSQGNDLVSPAF Q33DM4_XENLA Q33DM4_XENLA KVQAYTPVFSPHAAAPSLPLTFGRQDTRPENPKLKAEEISDFGRSSSVRSQGNDLVSPAI Q4JNX8_XENLA Q4JNX8_XENLA KVQAYTPVFSPHAAAPSLPLTFGRQDTRPENPKLKAEEISDFGRSSSVRSQGNDLVSPAI A3KMF3_MOUSE A3KMF3_MOUSE ----HNRVSDLLEVPGACGLDLSAEESQPQMSGKVNIADPDIQSEVSVQS---------- RECQ4_MOUSE RECQ4_MOUSE ----HNRVSDLLEVPGACGLDLSAEESQPQMSGKVNIADPDIQSEVSVQS---------- A5D786_BOVIN A5D786_BOVIN ----HNRTPDFLEVPRTCQPGLGAEDSQLLTPVVESVLSPSAGPEVPLQD---------- RECQ4_HUMAN RECQ4_HUMAN ----HSEVPDFLGAPKACRPDLGSEESQLLIPGESAVLGPGAGSQG-------------- MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4RLC3_TETNG Q4RLC3_TETNG ------------------------------------------------------------ A0JM06_XENTR A0JM06_XENTR KREGVWDPDQQPLERKFPVRQRICVESKASLAEAGMGAHNQLDSKGPMSNGSKQLQDIDV B1WBC8_XENLA B1WBC8_XENLA RREEIWDPEHQPLKRKSPLRKQICGESKMS-SEAGQVA--QLDSKGPMSEHSKRWQDTDE Q33DM4_XENLA Q33DM4_XENLA RREEIWDPEHQPLKRKSPLRKQICGESKMS-SEAGQVA--QLDSKGPMSEHSKRWQDTDE Q4JNX8_XENLA Q4JNX8_XENLA RREEIWDPEHQPLKRKSPLRKQICGESKMS-SEAGQVA--QLDSKGPMSEHSKRWQDTDE A3KMF3_MOUSE A3KMF3_MOUSE ------------------------------------------------------------ RECQ4_MOUSE RECQ4_MOUSE ------------------------------------------------------------ A5D786_BOVIN A5D786_BOVIN ------------------------------------------------------------ RECQ4_HUMAN RECQ4_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4RLC3_TETNG Q4RLC3_TETNG ------------------------------------------------------------ A0JM06_XENTR A0JM06_XENTR GQVMKNRTRPRQQSPQEVDGMPQETIAGGEASAILSKGKRKKRQREISAEQDAVEESPKV B1WBC8_XENLA B1WBC8_XENLA SRAMKNRTGQMQESLQEVD-MSQENIAAEQVSVILAKGKRKKRQRETSAEPDTVEVSPKV Q33DM4_XENLA Q33DM4_XENLA SRAMKNRTGQMQESLQEVD-MSQENIAAEQVSVILAKGKRKKRQRETSAEPDTVEVSPKV Q4JNX8_XENLA Q4JNX8_XENLA SRAMKNRTGQMQESLQEVD-MSQENIAAEQVSVILAKGKRKKRQRETSAEPDTVEVSPKV A3KMF3_MOUSE A3KMF3_MOUSE ---------------PEAIAQQPAQVLSQSPKSINSKGRKRKWNEK--GEDFAQD----- RECQ4_MOUSE RECQ4_MOUSE ---------------PEAIAQQPAQVLSQSPKSINSKGRKRKWNEK--GEDFAQD----- A5D786_BOVIN A5D786_BOVIN ---------------PEAPALPAAAVSAGKCQPVDRQGKKRRQSGELEGRLAQTQ----- RECQ4_HUMAN RECQ4_HUMAN ---------------PEASAFQEVSIRVGSPQPSSSGGEKRRWNEEPWESPAQVQ----- MATCH CONSENSUS ????????????????E????????????????????G??????????????????????

Q4RLC3_TETNG Q4RLC3_TETNG ------------------------------------------------------------ A0JM06_XENTR A0JM06_XENTR SKKRRKTKMSPDNGEKSSPVQNRRKRGAR-RNDSSDDPSMESPASEQGAKPVSEDLFGEL B1WBC8_XENLA B1WBC8_XENLA SKKRRKTNRSPDNSENSSSVRKRRKKGARCQMDDSDDPAMESPASEQVTKAVSEDLFGEL Q33DM4_XENLA Q33DM4_XENLA SKKRRKTNRSPDNSENSSSVRKRRKKGARCQMDDSDDPAMESPASEQVTKAVSEDLFGEL Q4JNX8_XENLA Q4JNX8_XENLA SKKRRKTNRSPDNSENSSSVRKRRKKGARCQMDDSDDPAMESPASEQVTKAVSEDLFGEL A3KMF3_MOUSE A3KMF3_MOUSE ---QPSSGAGPLSEGARATVHGQDPPGEPTQVNVPQPC-----------NSSNQARTEKA RECQ4_MOUSE RECQ4_MOUSE ---QPSSGAGPLSEGARATVHGQDPPGEPTQVNVPQPC-----------NSSNQARTEKA A5D786_BOVIN A5D786_BOVIN ---QGTDQAGPLPEGAGAAGPAEDCPDQPVKAQPP------------GRTPAS------- RECQ4_HUMAN RECQ4_HUMAN ---QESSQAGPPSEGAGAVAVEEDPPGEPVQAQPPQPCSSPSNPRYHGLSPSSQARAGKA MATCH CONSENSUS ??????????P?????????????????????????????????????????????????

Q4RLC3_TETNG Q4RLC3_TETNG -----------------------GNFVKINLKKKSHVKGYALRGVGLRKQLYMEKFQLKG A0JM06_XENTR A0JM06_XENTR EEETAQRISVKTAKATRMPQIKSENFVRINLKKKSHVKSFALNGQRLRKQMWKQKWQKKG B1WBC8_XENLA B1WBC8_XENLA EEEPVQRSSVKTVN-TRMPQIKSENFVRINLKKKSHVKCVALNGHRLRKQMWKQKWQKKG Q33DM4_XENLA Q33DM4_XENLA EEEPVQRSSVKTVN-TRMPQIKSENFVRINLKKKSHVKCVALNGHRLRKQMWKQKWQKKG Q4JNX8_XENLA Q4JNX8_XENLA EEEPVQRSSVKTVN-TRMPQIKSENFVRINLKKKSHVKCVALNGHRLRKQMWKQKWQKKG A3KMF3_MOUSE A3KMF3_MOUSE KGTTHLHAS------PRPASLDRGNYIRLNMKNKRFVRVGANRGRLLRKQVWKQKWKKKQ RECQ4_MOUSE RECQ4_MOUSE KGTTHLHAS------PRPASLDRGNYIRLNMKNKRFVRVGANRGRLLRKQVWKQKWKKKQ A5D786_BOVIN A5D786_BOVIN ----------------RSAIQDRGNYVRLNMKQRRYVRGRALRGRLLRKQAWKQKWQKKG RECQ4_HUMAN RECQ4_HUMAN EGTAPLHIF------PRLARHDRGNYVRLNMKQKHYVRGRALRSRLLRKQAWKQKWRKKG MATCH *::::*:*:: .*: * .. **** : :*:: * CONSENSUS ????????????????R???????N??R?N?K?K??V???A??G??LRKQ?WKQKW?KK?

Q4RLC3_TETNG Q4RLC3_TETNG ERF----GGGGRHFGRGRRGGFRGGFGRPGDTCYKCGGTGHWAMHCKGPAPAPSVPEDPP A0JM06_XENTR A0JM06_XENTR EQF----GGGGKHFNRG------------GDTCFRCGGIGHWASQCPGSVPVVRQEVVEI B1WBC8_XENLA B1WBC8_XENLA EQFGGGGGGGGKHFNRS------------GDTCFRCGGMGHWASQCPGSVPVVRQEVAET Q33DM4_XENLA Q33DM4_XENLA EQF-GGGGGGGKHFNRS------------GDTCFRCGGMGHWASQCPGSVPVVRQEVAET Q4JNX8_XENLA Q4JNX8_XENLA EQF----GGGGKHFNRS------------GDTCFRCGGMGHWASQCPGSVPVVRQEVAET A3KMF3_MOUSE A3KMF3_MOUSE AAF----GGSGPRATDK-------------DTCFRCGQFGHWASQCSQPGPTLTVQ-EEG RECQ4_MOUSE RECQ4_MOUSE AAF----GGSGPRATDK-------------DTCFRCGQFGHWASQCSQPGPTLTVQ-EEG A5D786_BOVIN A5D786_BOVIN ECF----GGGQPRAPAQ-------------DSCSQHGQLSQWASRCPQPEPLLVPQKDVK RECQ4_HUMAN RECQ4_HUMAN ECF----GGGGATVTTK-------------ESCFLNEQFDHWAAQCPRP----------- MATCH * **. ::* .:** :* . CONSENSUS ??F????GG?G???????????????????D?C???G???HWA??C????P?????????

Q4RLC3_TETNG Q4RLC3_TETNG ADEEPFELPTLEEVARATGTLRPQPTAASTSEEPSDQEKNAGVYPADEVLLNVIRPDYER A0JM06_XENTR A0JM06_XENTR EEEEEVSLPTLEDVARMTNT----------QLQSTSAEVPSGWCQGPVATLNVVRAVYEP B1WBC8_XENLA B1WBC8_XENLA EEEEEVSLPTLEDVARMTNT----------QLRPNTNEGPSGWCQDPVVTVNVVRAVYEP Q33DM4_XENLA Q33DM4_XENLA EEEEEVSLPTLEDVARMTNT----------QLRPNTNEGLSGWCQDPVVTVNVVRAVYEP Q4JNX8_XENLA Q4JNX8_XENLA EEEEEVSLPTLEDVARMTNT----------QLRPNTNEGLSGWCQDPVVTVNVVRAVYEP A3KMF3_MOUSE A3KMF3_MOUSE DRDDKQPISTLEEVAQRTGT---------ASCHHSGEETQPA---APEL---------QV RECQ4_MOUSE RECQ4_MOUSE DRDDKQPISTLEEVAQRTGT---------ASCHHSGEETQPA---APEL---------QV A5D786_BOVIN A5D786_BOVIN VADGAQTQPTLQEASLRTGA-------ACCQVSAGEEDAEPG---APELLVPTGQSVSRM RECQ4_HUMAN RECQ4_HUMAN ---------------------------------ASEEDTDAV---GPEPLVPSPQPVPEV MATCH : . . CONSENSUS ?????????TL??????T????????????????????????????P?????????????

Q4RLC3_TETNG Q4RLC3_TETNG PAPPPPVEPLYDLDDAGKVRGTTAEVYEALRELGYQSFRPGQEEAIMRILSGLSTLVVLS A0JM06_XENTR A0JM06_XENTR PEPPSPMQALYELEPDGKVKETPAEVYDTLSELGYSSFRPGQEQAVMRILSGLSSLVILS B1WBC8_XENLA B1WBC8_XENLA PTPPPPMQPLYELGPDGRVKETPSEVYDNLSELGYRSFRSGQEQAVMRILSGLSSLVILS Q33DM4_XENLA Q33DM4_XENLA PTPPPPMQPLYELGPDGRVKETPSEVYDNLSELGYRSFRSGQEQAVMRILSGLSSLVILS Q4JNX8_XENLA Q4JNX8_XENLA PTPPPPMQPLYELGPDGRVKETPSEVYDNLSELGYRSFRSGQEQAVMRILSGFSSLGILS A3KMF3_MOUSE A3KMF3_MOUSE PHCPTPMSPLYPPGPLGQVAETPAEVFQALERLGYRAFRPGQERAIMRILSGISTLLVLP RECQ4_MOUSE RECQ4_MOUSE PHCPTPMSPLYPPGPLGQVAETPAEVFQALERLGYRAFRPGQERAIMRILSGISTLLVLP A5D786_BOVIN A5D786_BOVIN PCPPLSVPPLYPPGPSGQVADTPAEVFQALEQLGHHAFYPGQERVVMRVLSGMSTLLVLP RECQ4_HUMAN RECQ4_HUMAN PSLDPTVLPLYSLGPSGQLAETPAEVFQALEQLGHQAFRPGQERAVMRILSGISTLLVLP MATCH * .: .** *:: *.:**:: * .**: :* .***..:**:***:*:* :*. CONSENSUS P??P????PLY???P?G?V??TP?EV???L??LG???FR?GQE?A?MRILSG?S?L??L?

Q4RLC3_TETNG Q4RLC3_TETNG TGMGKSLCYQLPAYMYAKRFKTITLVISPLVSLMDDQLSGLPASLKAACIHSNMTMKQRE A0JM06_XENTR A0JM06_XENTR TGMGKSLCYQLPAYMYAKRSRCITLVISPLVSLMDDQVSGLPPKLKAVCIHSNMTRTQRE B1WBC8_XENLA B1WBC8_XENLA TGMGKSLCYQLPAYMYAKRSRCISLVISPLVSLMDDQVSGLPPKLKAVCIHSNMTRTQRE Q33DM4_XENLA Q33DM4_XENLA TGMGKSLCYQLPAYMYAKRSRCISLVISPLVSLMDDQVSGLPPKLKAVCIHSNMTRTQRE Q4JNX8_XENLA Q4JNX8_XENLA TGMGKSLCYQLPAYMYAKRSRCISLVISPLVSLMDDQVSGLSPKLKAVCIHSNMTRTQRE A3KMF3_MOUSE A3KMF3_MOUSE TGAGKSMCYQLPALLYAQRSPCLTLVVSPLLSLMDDQVSDLPSCLKAACLHSGMTKKQRE RECQ4_MOUSE RECQ4_MOUSE TGAGKSLCYQLPALLYAQRSPCLTLVVSPLLSLMDDQVSDLPSCLKAACLHSGMTKKQRE A5D786_BOVIN A5D786_BOVIN TGAGKSLCYQLPALLYFRRSPCLTLVISPLTSLMDDQLSGLPPGLKGACIHSGMTKKQRD RECQ4_HUMAN RECQ4_HUMAN TGAGKSLCYQLPALLYSRRSPCLTLVVSPLLSLMDDQVSGLPPCLKAACIHSGMTRKQRE MATCH ** ***:****** :* :* ::**:*** ******:*.*.. **..*:**.** .**: CONSENSUS TG?GKSLCYQLPA??Y??RS?C??LV?SPL?SLMDDQ?S?LP??LKA?C?HS?MT??QRE

Q4RLC3_TETNG Q4RLC3_TETNG AAVEKVKSGQVCVLLLSPEALVGGGGSGSGCLPSAQELPPVAFACIDEAHCVSEWSHNFR A0JM06_XENTR A0JM06_XENTR TAIEKVKQGKVHVLLLSPEALVGGGQSGSSCLPPAEQLPPVAFACIDEAHCVSEWSHNFR B1WBC8_XENLA B1WBC8_XENLA AAIEKVKQGKVHVLLLSPEALVGGGFSGSSCLPPADQLPPVAFACIDEAHCVSEWSHNFR Q33DM4_XENLA Q33DM4_XENLA AAIEKVKQGKVHVLLLSPEALVGGGFSGSSCLPPADQLPPVAFACIDEAHCVSEWSHNFR Q4JNX8_XENLA Q4JNX8_XENLA AAIEKVKQGKVHVLLLSPEALVGGGFSGSSCLPPADQLPPVAFACIDEAHCVSEWSHNFR A3KMF3_MOUSE A3KMF3_MOUSE SVLKKVRAAQVHVLIVSPEALVGCGARGPGSLPQAAQLPPIAFACIDEVHCLSQWSHNFR RECQ4_MOUSE RECQ4_MOUSE SVLKKVRAAQVHVLIVSPEALVGCGARGPGSLPQAAQLPPIAFACIDEVHCLSQWSHNFR A5D786_BOVIN A5D786_BOVIN SALQKARAARVQVLMLSPEALVGAGA-----STLLSQLPPVAFACLDEAHCLSQWSHNFR RECQ4_HUMAN RECQ4_HUMAN SVLQKIRAAQVHVLMLTPEALVGAGG-----LPPAAQLPPVAFACIDEAHCLSQWSHNFR MATCH :.::* : .:* **:::****** * . :***:****:**.**:*:****** CONSENSUS ????K?????V?VL??SPEALVG?G??????LP?A?QLPP?AFACIDE?HC?S?WSHNFR

Q4RLC3_TETNG Q4RLC3_TETNG PCYLRLCKVLRDRLGVQCLLGLTATATLSTALDIARHLDINDQDGIAVRSAAVPPNLHLS A0JM06_XENTR A0JM06_XENTR PCYLRLCKVLRERLGVNCLLGLTATATRATAEDVARHLGVSQEGGIPVRMASVPPNLHLS B1WBC8_XENLA B1WBC8_XENLA PCYLRLCKVLRERLGVNCLLGLTATATRATAEDVAHHLGVSPEGGIPVRMASVPPNLHLS Q33DM4_XENLA Q33DM4_XENLA PCYLRLCKVLRERLGVNCLLGLTATATRATAEDVAHHLGVSPEGGIPVRMASVPPNLHLS Q4JNX8_XENLA Q4JNX8_XENLA PCYLRLCKVLRERLGVNCLLGLTATATRATAEDVAHHLGVSPEGGIPVRMASVPPNLHLS A3KMF3_MOUSE A3KMF3_MOUSE PCYLRVCKVLREHMGVRCFLGLTATATRSTARDVAQHLGIAGEFELS-GSANIPANLHLS RECQ4_MOUSE RECQ4_MOUSE PCYLRVCKVLREHMGVRCFLGLTATATRSTARDVAQHLGIAGEFELS-GSANIPANLHLS A5D786_BOVIN A5D786_BOVIN PCYLRVCQTLRDQMGVHCFLGLTATATRSTALDVAWHLGVTEESVLR-GPATIPDNLHLS RECQ4_HUMAN RECQ4_HUMAN PCYLRVCKVLRERMGVHCFLGLTATATRRTASDVAQHLAVAEEPDLH-GPAPVPTNLHLS MATCH *****:*:.**:::**.*:******** ** *:* ** : : : * :* ***** CONSENSUS PCYLR?CKVLR???GV?C?LGLTATATR?TA?DVA?HL????E???????A??P?NLHLS

Q4RLC3_TETNG Q4RLC3_TETNG VSTDREKDQALVSLLKGERFGCLDSIIVYCTRREETVRVAALLRTCLQGVFV-------- A0JM06_XENTR A0JM06_XENTR VSMDRNRDQALVTLLKGERFGCLDSVIVYCTRREETQRISALLRTSLQGVTV---SNLNS B1WBC8_XENLA B1WBC8_XENLA VSMDRNRDQALVTLLKGERFGCLDSVIVYCTRREETQRISALLRTSLQGVTVSANSHLNS Q33DM4_XENLA Q33DM4_XENLA VSMDRNRDQALVTLLKGERFGCLDSVIVYCTRREETQRISALLRTSLQGVTVSANSHLNS Q4JNX8_XENLA Q4JNX8_XENLA VSMDRNRDQALVTLLKGERFGCLDSVIVYCTRREETQRISALLRTSLQGVTVSANSHLNS A3KMF3_MOUSE A3KMF3_MOUSE VSMDRDSDQALVTLLQGDRFRTLDSVIIYCTRRKDTERVAALLRTCLSMVGD-------- RECQ4_MOUSE RECQ4_MOUSE VSMDRDSDQALVTLLQGDRFRTLDSVIIYCTRERIQNGWLALLRTCLSMVGD-------- A5D786_BOVIN A5D786_BOVIN VSSDRDPDQALVTLLRSDRFRALGSVIIYCHRREDTERVAALLRTCLCDAQD-------- RECQ4_HUMAN RECQ4_HUMAN VSMDRDTDQALLTLLQGKRFQNLDSIIIYCNRREDTERIAALLRTCLHAAWV-------- MATCH ** **: ****::**:..** *.*:*:** *.. *****.* . CONSENSUS VS?DR??DQALVTLL?G?RF??LDS?I?YC?RR??T?R??ALLRT?L?????????????

Q4RLC3_TETNG Q4RLC3_TETNG -------KENKQTGSTRKKIRKPLKWQAESYHAGLSAAERRRVQNNFMCGELRIVVATVA A0JM06_XENTR A0JM06_XENTR QEQEEATVSDRKKAQALKKIRRPLKWIAESYHAGMSAAERRRVQNNFMCGQLRLVVATVA B1WBC8_XENLA B1WBC8_XENLA QEQEDTTVSDRKKAQALKKIRRPLKWIAESYHAGMSAAERRRVQNNFMCGQLRLVVATVA Q33DM4_XENLA Q33DM4_XENLA QEQEDTTVSDRKKAQALKKIRRPLKWIAESYHAGMSAAERRRVQNNFMCGQLRLVVATVA Q4JNX8_XENLA Q4JNX8_XENLA QEQEDTTVSDRKKAQALKKIRRPLKWIAESYHAGMSAAERRRVQNNFMCGQLRLVVATVA A3KMF3_MOUSE A3KMF3_MOUSE ---------SRPRGCGPEAI-------AEAYHAGMSSQERRRVQQAFMRGHLRMVVATVA RECQ4_MOUSE RECQ4_MOUSE ---------SRPRGCGPEAI-------AEAYHAGMSSQERRRVQQAFMRGHLRMVVATVA A5D786_BOVIN A5D786_BOVIN ---------PGPHGRALEAV-------AEAYHAGLCSRERRRVQRAFMEGRLRMVVATVA RECQ4_HUMAN RECQ4_HUMAN ---------PGSGGRAPKTT-------AEAYHAGMCSRERRRVQRAFMQGQLRVVVATVA MATCH . : **:****:.: ******. ** *.**:****** CONSENSUS ???????????????????????????AE?YHAG????ERRRVQ??FM?G?LR?VVATVA

Q4RLC3_TETNG Q4RLC3_TETNG FGMGLDKSDVRGIVHYNMPKSFESYVQEIGRAGRDGESAHCHLFLDPEGGDLHELRRHIY A0JM06_XENTR A0JM06_XENTR FGMGLDKSDVRGIIHYNMPKNFESYVQEIGRAGRDGKDAQCHLFLDPEEHDMDELRRHIY B1WBC8_XENLA B1WBC8_XENLA FGMGLDKSDVRGIIHYNMPKNFESYVQEIGRAGRDGKDAQCHLFLDPEGQDMDELRRHIY Q33DM4_XENLA Q33DM4_XENLA FGMGLDKSDVRGIIHYNMPKNFESYVQEIGRAGRDGKDAQCHLFLDPEGQDMDELRRHIY Q4JNX8_XENLA Q4JNX8_XENLA FGMGLDKSDVRGIIHYNMPKNFESYVQEIGRAGRDGKDAQCHLFLDPEGQDMDELRRHIY A3KMF3_MOUSE A3KMF3_MOUSE FGMGLDRPDVRAVLHLGLPPSFESYVQAIGRAGRDGKPAHCHLFMHPQGEDLWELRRHAH RECQ4_MOUSE RECQ4_MOUSE FGMGLDRPDVRAVLHLGLPPSFESYVQAIGRAGRDGKPAHCHLFMHPQGEDLWELRRHAH A5D786_BOVIN A5D786_BOVIN FGMGLDRPDVRAVLHLGLPPSFETYVQAVGRAGRDGQPAHCHLFLRPQGQDLRELRRHVH RECQ4_HUMAN RECQ4_HUMAN FGMGLDRPDVRAVLHLGLPPSFESYVQAVGRAGRDGQPAHCHLFLQPQGEDLRELRRHVH MATCH ******:.***.::* .:* .**:*** :*******: *:****: *: *: ***** : CONSENSUS FGMGLD??DVR???H???P??FESYVQ??GRAGRDG??A?CHLF??P?G?D??ELRRH??

Q4RLC3_TETNG Q4RLC3_TETNG ADTVDYYTVKKLVQKVFPP--CKCKQIQQKHQ-------------------ELVKEEGSS A0JM06_XENTR A0JM06_XENTR SDSVDCITVKRLVQKVFPK--CKCRDLEREQQALTNAGEVEDSELLEFLAQSGEEQDGMC B1WBC8_XENLA B1WBC8_XENLA TDSVDYIAVKKLVRKVFPK--CKCRDLHREQQALINAGEVDDSELLQFL-EQGEEQDSMC Q33DM4_XENLA Q33DM4_XENLA TDSVDYIAVKKLVRKVFPK--CKCRDLHREQQALINAGEVDDSELLQFL-EQGEEQDSMC Q4JNX8_XENLA Q4JNX8_XENLA TDSVDYIAVKKLVRKVFPK--CKCRDLHREQQALINAGEVDDSELLQFL-EQGEEQDSMC A3KMF3_MOUSE A3KMF3_MOUSE ADSTDFLAVKRLVQCVFPP--CTCSQRPVSKSS----------------PEEVKEHSGQQ RECQ4_MOUSE RECQ4_MOUSE ADSTDFLAVKRLVQRVFPP--CTCSQRPVSKSS----------------PEEVKEHSGQQ A5D786_BOVIN A5D786_BOVIN ANAVDFFAVKRLVQRVFPP--CACARQPPEQEG------------------SRSEEGHLA RECQ4_HUMAN RECQ4_HUMAN ADSTDFLAVKRLVQRVFPACTCTCTRPPSEQEG------------------AVGGERPVP MATCH :::.* :**:**: *** * * .:. . CONSENSUS ?D??D???VK?LV??VFP???C?C????????????????????????????????????

Q4RLC3_TETNG Q4RLC3_TETNG DWPCP------------------------------------------RVCHTHERAIPIQ A0JM06_XENTR A0JM06_XENTR DTPSSGTDPVCDTPSSGRDPVCDTPVSGRDPVCDTPIIGRDPSMRTPRLCHRHERAIPIE B1WBC8_XENLA B1WBC8_XENLA DTPSSGRDPVCDTPSMGAE----------------------------RLCHRHERAVPIE Q33DM4_XENLA Q33DM4_XENLA DTPSSGRDPVCDTPSMGAE----------------------------RLCHRHERAVPIE Q4JNX8_XENLA Q4JNX8_XENLA DTPSSGRDPVCDTPSMGAE----------------------------RLCHRHERAVPIE A3KMF3_MOUSE A3KMF3_MOUSE TYPVLG-----------------------------------------QACLGHERALPVQ RECQ4_MOUSE RECQ4_MOUSE TYPVLG-----------------------------------------QACLGHERALPVQ A5D786_BOVIN A5D786_BOVIN GAPVAASAQDSGQPSVPHT----------------------------PRCPGHERVLPVQ RECQ4_HUMAN RECQ4_HUMAN KYPPQEAEQLSHQAAPGPR----------------------------RVCMGHERALPIQ MATCH * * ***.:*:: CONSENSUS ??P??????????????????????????????????????????????C??HERA?P??

Q4RLC3_TETNG Q4RLC3_TETNG QTVEALDITEEGVETLLCYLELHPQRFVELLHPTLSVCKISCYDGPRQLRRVTKICPPVA A0JM06_XENTR A0JM06_XENTR ETVQGLDIREEAIETLLCYLELHPSHWLEQMHPTLSHCRVVCYSGPQQLRQLASSCPPVA B1WBC8_XENLA B1WBC8_XENLA ETVQSLDIREEAIETMLCYLELNPSHWLEQLHPTLSHCRVVCYSGPQQLRLLARSCPPVA Q33DM4_XENLA Q33DM4_XENLA ETVQSLDIREEAIETMLCYLELNPSHWLEQLHPTLSHCRVVCYSGPQQLRLLARSCPPVA Q4JNX8_XENLA Q4JNX8_XENLA ETVQSLDIREEAIETMLCYLELNPSHWLEQLHPTLSHCRVVCYSGPQQLRLLARSCPPVA A3KMF3_MOUSE A3KMF3_MOUSE STVQALDMTEEAIETLLCYLELHPRHWLELLPWTYAQCHLHCLGGSAQLQALAHRCPPLA RECQ4_MOUSE RECQ4_MOUSE STVQALDMTEEAIETLLCYLELHPRHWLELLPWTYAQCHLHCLGGSAQLQALAHRCPPLA A5D786_BOVIN A5D786_BOVIN PTVQALDMPEEAIETLLCYLELHPRRWLKLLAPTYARCHLRWPGGPTQLQALARRCPPLA RECQ4_HUMAN RECQ4_HUMAN LTVQALDMPEEAIETLLCYLELHPHHWLELLATTYTHCRLNCPGGPAQLQALAHRCPPLA MATCH **:.**: **.:**:******:* :::: : * : *:: .*. **: :: ***:* CONSENSUS ?TVQ?LD??EEAIET?LCYLEL?P??WLE?L??T???C???C??G??QL??LA??CPP?A

Q4RLC3_TETNG Q4RLC3_TETNG VVLARRRMAGERVESCDQLEFDVVEVADTMGWQLPLVKRGLRQLQWSTG-----QGGGRS A0JM06_XENTR A0JM06_XENTR VCLARERLAGVDHTHVSSVEFNVVELADSMGWEMVPVKRALRDLQWKQQPERGFKGTGRS B1WBC8_XENLA B1WBC8_XENLA VCLARERLAGVDHTHVSSTEFNVVELADSMGWEVVPVKRALRDLQWRRQPDKGFKGTGRS Q33DM4_XENLA Q33DM4_XENLA VCLARERLAGVDHTHVSSTEFNVVELADSMGWEVVPVKRALRDLQWRRQPDKGFKGTGRS Q4JNX8_XENLA Q4JNX8_XENLA VCLARERLAGVDHTHVSSTEFNVVELADSMGWEVVPVKRALRDLQWRRQPDKGFKGTGRS A3KMF3_MOUSE A3KMF3_MOUSE ACQAKW-PPKDTSQGRSSLEFGVVELADSMGWKLASVRQALHQLKWDPEPKKGAAQG--T RECQ4_MOUSE RECQ4_MOUSE ACQAKW-PPKDTSQGRSSLEFGVVELADSMGWKLASVRQALHQLKWDPEPKKGAAQG--T A5D786_BOVIN A5D786_BOVIN LCLAQQ-HP-DTKQGCSSVELDLVELADSTGWELGPVRRALLQLQWDPEPGTGVPQG--T RECQ4_HUMAN RECQ4_HUMAN VCLAQQ-LPEDPGQGSSSVEFDMVKLVDSMGWELASVRRALCQLQWDHEPRTGVRRG--T MATCH *: . .. *:.:*::.*: **:: *::.* :*:* : CONSENSUS ?C?A????????????SS?EF??VELADSMGW????V??AL??L?W???P??G???????

Q4RLC3_TETNG Q4RLC3_TETNG GVHVEFSSLSFYFRSYGDLSDEELDRVCQFLHHRVRNQENTQLFQLTACFKAFKSVAFRS A0JM06_XENTR A0JM06_XENTR GVLVEFGRLSFHFRSYGDLTDQELDEVCDFLHQKVTSRERTSLNQLKSCFRAFQSVAYRT B1WBC8_XENLA B1WBC8_XENLA GVLVEFSKLSFHFRSYGDLTDQELDQVCDFLHHKVTSRERTSLNQLKSCFHAFQSVAYRT Q33DM4_XENLA Q33DM4_XENLA GVLVEFSKLSFHFRSYGDLTDQELDQVCDFLHHKVTSRERTSLNQLKSCFHAFQSVAYRT Q4JNX8_XENLA Q4JNX8_XENLA GVLVEFSKLSFHFRSYGDLTDQELDQVCDFLHHKVTSRERTSLNQLKSCFHAFQSVAYRT A3KMF3_MOUSE A3KMF3_MOUSE GVLVKFSELAFHLHSRGDLTDEEKDQICDFLYNRVQAREHKALAHLHQMSKAFRSVAFPS RECQ4_MOUSE RECQ4_MOUSE GVLVKFSELAFHLHSRGDLTDEEKDQICDFLYNRVQAREHKALAHLHQMSKAFRSVAFPS A5D786_BOVIN A5D786_BOVIN GVLVEFRETAFRLHSPGDLTAQERDQICDFLHSRVQAREREALANLHHTFQAFHSVAFPS RECQ4_HUMAN RECQ4_HUMAN GVLVEFSELAFHLRSPGDLTAEEKDQICDFLYGRVQARERQALARLRRTFQAFHSVAFPS MATCH ** *:* :* ::* ***: :* *.:*:**: :* :*. * .* :**:***: : CONSENSUS GVLV?F??L?F???S?GDLT??E?D??CDFL???V??RE???L??L?????AF?SVA???

Q4RLC3_TETNG Q4RLC3_TETNG VSSCQDQLDDTRSLQLKSLLSEYFDKRR-EGDRVPAPEDYEGLDRYKVLDWEDQIRADIR A0JM06_XENTR A0JM06_XENTR SSACAEQISAERSAQLKALLWEYFEKRV-TE-EAKVEDPDEELREIKLQESKDQVRSDIR B1WBC8_XENLA B1WBC8_XENLA SSACAEKMSAERSAQLKALLLDYFEKRD-TELEAKVEDPDEELQQIKVQEAKDQVRSDVR Q33DM4_XENLA Q33DM4_XENLA SSACAEKMSAERSAQLKALLLDYFEKRD-TELEAKVEDPDEELQQIKVQEAKDQVRSDVR Q4JNX8_XENLA Q4JNX8_XENLA SSACAEKMSAERSAQLKALLLDYFEKRD-TELEAKVEDPDEELQQIKVQEAKDQVRSDVR A3KMF3_MOUSE A3KMF3_MOUSE CGPCLEQSNEEHSNQVKTLVSYYFEEEE-EEEETMTDTQGPKPGQTQLQDWEDQIRRDVR RECQ4_MOUSE RECQ4_MOUSE CGPCLEQSNEEHSNQVKTLVSYYFEEEE-EEEETMTDTQGPKPGQTQLQDWEDQIRRDVR A5D786_BOVIN A5D786_BOVIN CGPCLEQPAWERSSRLKALLSHYFEEES-EQPGGLETEDDPELGQDRLQDWEDQIRRDIR RECQ4_HUMAN RECQ4_HUMAN CGPCLEQQDEERSTRLKDLLGRYFEEEEGQEPGGMEDAQGPEPGQARLQDWEDQVRCDIR MATCH ..* :: :* ::* *: **::. . :: : :**:* *:* CONSENSUS ???C?E????E?S???K?L???YFE???????????????????????Q???DQ?R?D?R

Q4RLC3_TETNG Q4RLC3_TETNG SFLANRSDEKFSGRAVARILHGIGSPCYPAQTYGKDRRYWRKYIQFDFNQLIRLATQEII A0JM06_XENTR A0JM06_XENTR HFLSIHQEERFSGRALARIFHGIGSPCYPAQVFGRDRRFWRKYIHLDFNELMNLSKEEII B1WBC8_XENLA B1WBC8_XENLA HFLSIHEEERFSGRALARIFHGIGSPCYPAQVYGRDRRFWRKYIHLDFNEIMNLSKEEII Q33DM4_XENLA Q33DM4_XENLA HFLSIHEEERFSGRALARIFHGIGSPCYPAQVYGRDRRFWRKYIHLDFNEIMNLSKEEII Q4JNX8_XENLA Q4JNX8_XENLA HFLSIHEEERFSGRALARIFHGIGSPCYPAQVYGRDRRFWRKYIHLDFNEIMNLSKEEII A3KMF3_MOUSE A3KMF3_MOUSE QLLSLRPEERFSGRAVARIFHGIASPCYPAQVYGLDRRFWRKYLHLDFHALMHLATEELL RECQ4_MOUSE RECQ4_MOUSE QLLSLRPEERFSGRAVARIFHGIASPCYPAQVYGLDRRFWRKYLHLDFHALMHLATEELL A5D786_BOVIN A5D786_BOVIN QLLSSWPEQRFSGRAVARVFHGIGSPCYPAQVFGRDRRFWRKYLHLSFPALMHLATQELL RECQ4_HUMAN RECQ4_HUMAN QFLSLRPEEKFSSRAVARIFHGIGSPCYPAQVYGQDRRFWRKYLHLSFHALVGLATEELL MATCH :*: :::**.**:**::***.*******.:* ***:****:::.* :: *:.:*:: CONSENSUS ??LS???EE?FSGRA?ARIFHGI?SPCYPAQV?G?DRRFWRKY?HL?F?????L???E??

Q4RLC3_TETNG Q4RLC3_TETNG G--- A0JM06_XENTR A0JM06_XENTR RLK- B1WBC8_XENLA B1WBC8_XENLA RLK- Q33DM4_XENLA Q33DM4_XENLA RLK- Q4JNX8_XENLA Q4JNX8_XENLA RLK- A3KMF3_MOUSE A3KMF3_MOUSE LRGR RECQ4_MOUSE RECQ4_MOUSE LRGR A5D786_BOVIN A5D786_BOVIN LWGR RECQ4_HUMAN RECQ4_HUMAN QVAR MATCH CONSENSUS ????


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