Alignment of the gene Family HBG067762 of HOVERGEN

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Isoforms are ON
B1H1Q6_XENLA B1H1Q6_XENLA ------------------------------------------------------------ Q1ECW3_DANRE Q1ECW3_DANRE ------------------------------------------------------------ Q4STF4_TETNG Q4STF4_TETNG ------------------------------------------------------------ Q4S0D0_TETNG Q4S0D0_TETNG ------------------------------------------------------------ Q4T3X7_TETNG Q4T3X7_TETNG ------------------------------------------------------------ Q4RY11_TETNG Q4RY11_TETNG ------------------------------------------------------------ A8WGG7_XENTR A8WGG7_XENTR ------------------------------------------------------------ A2ALX6_MOUSE A2ALX6_MOUSE ------------------------------------------------------------ Q8C8B2_MOUSE Q8C8B2_MOUSE ------------------------------------------------------------ RHG06_MOUSE RHG06_MOUSE ------------------------------------------------------------ A2ALX7_MOUSE A2ALX7_MOUSE ------------------------------------------------------------ B4DN07_HUMAN B4DN07_HUMAN ------------------------------------------------------------ A8KAL3_HUMAN A8KAL3_HUMAN ------------------------------------------------------------ B4DN35_HUMAN B4DN35_HUMAN ------------------------------------------------------------ RHG06_HUMAN RHG06_HUMAN ------------------------------------------------------------ B7Z8H7_HUMAN B7Z8H7_HUMAN ------------------------------------------------------------ Q59HG6_HUMAN Q59HG6_HUMAN AGDGSAAPAAAGALGAHRRRVSWALLSTALGKPRASPAWHLCLSPFRFPTQSHQRPGREE MATCH CONSENSUS ????????????????????????????????????????????????????????????

B1H1Q6_XENLA B1H1Q6_XENLA ------------------------------------------------------------ Q1ECW3_DANRE Q1ECW3_DANRE ------------------------------------------------------------ Q4STF4_TETNG Q4STF4_TETNG ------------------------------------------------------------ Q4S0D0_TETNG Q4S0D0_TETNG ------------------------------------------------------------ Q4T3X7_TETNG Q4T3X7_TETNG ------------------------------------------------------------ Q4RY11_TETNG Q4RY11_TETNG ------------------------------------------------------------ A8WGG7_XENTR A8WGG7_XENTR ------------------------------------------------------------ A2ALX6_MOUSE A2ALX6_MOUSE ------------------------------------------------------------ Q8C8B2_MOUSE Q8C8B2_MOUSE ------------------------------------------------------------ RHG06_MOUSE RHG06_MOUSE ----------MSAQSLLHSVFSCSSPASGGTASAKGFSKRKLRQTRSLDPALIGGCGS-E A2ALX7_MOUSE A2ALX7_MOUSE ------------------------------------------------------------ B4DN07_HUMAN B4DN07_HUMAN ------------------------------------------------------------ A8KAL3_HUMAN A8KAL3_HUMAN ----------MSAQSLLHSVFSCSSPASSSAASAKGFSKRKLRQTRSLDPALIGGCGSDE B4DN35_HUMAN B4DN35_HUMAN ------------------------------------------------------------ RHG06_HUMAN RHG06_HUMAN ----------MSAQSLLHSVFSCSSPASSSAASAKGFSKRKLRQTRSLDPALIGGCGSDE B7Z8H7_HUMAN B7Z8H7_HUMAN ------------------------------------------------------------ Q59HG6_HUMAN Q59HG6_HUMAN EVVLRCSPAEMSAQSLLHSVFSCSSPASSSAASAKGFSKRKLRQTRSLDPALIGGCGSDE MATCH CONSENSUS ????????????????????????????????????????????????????????????

B1H1Q6_XENLA B1H1Q6_XENLA ------------------------------------------------------------ Q1ECW3_DANRE Q1ECW3_DANRE ------------------------------------------------------------ Q4STF4_TETNG Q4STF4_TETNG ------------------------------------------------------------ Q4S0D0_TETNG Q4S0D0_TETNG ----------------------VCLRPQ-------------------------------- Q4T3X7_TETNG Q4T3X7_TETNG ------------------------------------------------------------ Q4RY11_TETNG Q4RY11_TETNG ------------------------------------------------------------ A8WGG7_XENTR A8WGG7_XENTR ------------------------------------------------------------ A2ALX6_MOUSE A2ALX6_MOUSE -----------------MGDPSYSEKPRLHYA---------------------------- Q8C8B2_MOUSE Q8C8B2_MOUSE -----------------MGDPSYSEKPRLHYA---------------------------- RHG06_MOUSE RHG06_MOUSE MGAEGGLRGSTVSRLHSPQLLAEGLGSRLASSPRSQHLRATRFQTPRPLCSSFSTPSTPQ A2ALX7_MOUSE A2ALX7_MOUSE -----------------MGDPSYSEKPRLHYA---------------------------- B4DN07_HUMAN B4DN07_HUMAN ------------------MKRLHIFGPKIHSS---------------------------- A8KAL3_HUMAN A8KAL3_HUMAN AGAEGSARGATAGRLYSPSLPAESLGPRLASSSRGPPPRATRLPPPGPLCSSFSTPSTPQ B4DN35_HUMAN B4DN35_HUMAN ------------------------------------------------------------ RHG06_HUMAN RHG06_HUMAN AGAEGSARGATAGRLYSPSLPAESLGPRLASSSRGPPPRATRLPPPGPLCSSFSTPSTPQ B7Z8H7_HUMAN B7Z8H7_HUMAN ------------------------------------------------------------ Q59HG6_HUMAN Q59HG6_HUMAN AGAEGSARGATAGRLYSPSLPAESLGPRLASSSRGPPPRATRLPPPGPLCSSFSTPSTPQ MATCH CONSENSUS ????????????????????????????????????????????????????????????

B1H1Q6_XENLA B1H1Q6_XENLA ------------------------------------------------------------ Q1ECW3_DANRE Q1ECW3_DANRE ------------------------------------------------------------ Q4STF4_TETNG Q4STF4_TETNG ------------------------------------------------------------ Q4S0D0_TETNG Q4S0D0_TETNG ------------------------------------------------------------ Q4T3X7_TETNG Q4T3X7_TETNG ------------------------------------------------------------ Q4RY11_TETNG Q4RY11_TETNG ------------------------------------------------------------ A8WGG7_XENTR A8WGG7_XENTR ------------------------------------------------------------ A2ALX6_MOUSE A2ALX6_MOUSE ------------------------------------------------------------ Q8C8B2_MOUSE Q8C8B2_MOUSE ------------------------------------------------------------ RHG06_MOUSE RHG06_MOUSE EKSPSGSFHFDYEVPLSRSGLKKSMAWDLPSVLAGSGSASSRSPASILSSSGGGPNGIFS A2ALX7_MOUSE A2ALX7_MOUSE ------------------------------------------------------------ B4DN07_HUMAN B4DN07_HUMAN ------------------------------------------------------------ A8KAL3_HUMAN A8KAL3_HUMAN EKSPSGSFHFDYEVPLGRGGLKKSMAWDLPSVLA--GPASSRSASSILCSSGGGPNGIFA B4DN35_HUMAN B4DN35_HUMAN ------------------------------------------------------------ RHG06_HUMAN RHG06_HUMAN EKSPSGSFHFDYEVPLGRGGLKKSMAWDLPSVLA--GPASSRSASSILCSSGGGPNGIFA B7Z8H7_HUMAN B7Z8H7_HUMAN ------------------------------------------------------------ Q59HG6_HUMAN Q59HG6_HUMAN EKSPSGSFHFDYEVPLGRGGLKKSMAWDLPSVLA--GPASSRSASSILCSSGGGPNGIFA MATCH CONSENSUS ????????????????????????????????????????????????????????????

B1H1Q6_XENLA B1H1Q6_XENLA -----------------------------------MLGPVLQLHAVHLQSLSELERFRLR Q1ECW3_DANRE Q1ECW3_DANRE -----------------------------------MLGQSVRLQPVAIQSLSELERARLQ Q4STF4_TETNG Q4STF4_TETNG ------------------------------------------------------------ Q4S0D0_TETNG Q4S0D0_TETNG ----------------------------GDFTWKSVSGRSIGLKPVPLQSLSELERCRLQ Q4T3X7_TETNG Q4T3X7_TETNG ---------------------------QGDFTWKSVSGRSIGLKPVPLQSLSELERCRLQ Q4RY11_TETNG Q4RY11_TETNG --------------------------NQGDFTWSSLSGRSVRLTPVDIQSLSELERARLQ A8WGG7_XENTR A8WGG7_XENTR -----------------------------------MSGRSVRLKSVPIQSLSELERARLQ A2ALX6_MOUSE A2ALX6_MOUSE ----------------------------GDFTWNSMSGRSVRLRSVPIQSLSELERARLQ Q8C8B2_MOUSE Q8C8B2_MOUSE ----------------------------GDFTWNSMSGRSVRLRSVPIQSLSELERARLQ RHG06_MOUSE RHG06_MOUSE SPRRWLQQRKFQPPPNSRSHPYVVWRSEGDFTWNSMSGRSVRLRSVPIQSLSELERARLQ A2ALX7_MOUSE A2ALX7_MOUSE ----------------------------GDFTWNSMSGRSVRLRSVPIQSLSELERARLQ B4DN07_HUMAN B4DN07_HUMAN ---------------------GGLWQQKGDFTWNSMSGRSVRLRSVPIQSLSELERARLQ A8KAL3_HUMAN A8KAL3_HUMAN SPRRWLQQRKFQSPPDSRGHPYVVWKSEGDFTWNSMSGRSVRLRSVPIQSLSELERARLQ B4DN35_HUMAN B4DN35_HUMAN ------------------------------------------------------------ RHG06_HUMAN RHG06_HUMAN SPRRWLQQRKFQSPPDSRGHPYVVWKSEGDFTWNSMSGRSVRLRSVPIQSLSELERARLQ B7Z8H7_HUMAN B7Z8H7_HUMAN -----------------------MYRIFGDFTWNSMSGRSVRLRSVPIQSLSELERARLQ Q59HG6_HUMAN Q59HG6_HUMAN SPRRWLQQRKFQSPPDSRGHPYVVWKSEGDFTWNSMSGRSVRLRSVPIQSLSELERARLQ MATCH CONSENSUS ?????????????????????????????????????G?S??L??V??QSLSELER?RLQ

B1H1Q6_XENLA B1H1Q6_XENLA EISLYQLHEH---GLCSDITPDQNKARKSVRRRLER--------RDAPPGLFGVPLSDVI Q1ECW3_DANRE Q1ECW3_DANRE EVALYHLERR-DLDFKISIPREIRKRRKSLRRKFDSFSKEK-KDRESAPKAFSIPLSQVI Q4STF4_TETNG Q4STF4_TETNG -------------------------------------------------MAFGIPLSQVI Q4S0D0_TETNG Q4S0D0_TETNG DVAFRRMLRDRDMGCHITIPKYGHKHKKSLRQKLDSLSKEKSKDKEIPPLVFGVPLSQVI Q4T3X7_TETNG Q4T3X7_TETNG DVAFRRMLRDRDMGCHITIPKYGHKHKKSLRQKLDSLSKEKSKDKEIPPLVFGVPLSQVI Q4RY11_TETNG Q4RY11_TETNG EVAFTRLHQDYDLGCQITMPKDGQKRKKSLRRKLDSLAKEKSKDKEFIPQAFSIPLSQVI A8WGG7_XENTR A8WGG7_XENTR EVAFYRLQQDYDLNCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFLPQAFGMPLSQVI A2ALX6_MOUSE A2ALX6_MOUSE EVAFYQLQQDCDLGCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVI Q8C8B2_MOUSE Q8C8B2_MOUSE EVAFYQLQQDCDLGCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVI RHG06_MOUSE RHG06_MOUSE EVAFYQLQQDCDLGCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVI A2ALX7_MOUSE A2ALX7_MOUSE EVAFYQLQQDCDLGCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVI B4DN07_HUMAN B4DN07_HUMAN EVAFYQLQQDCDLSCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVI A8KAL3_HUMAN A8KAL3_HUMAN EVAFYQLQQDCDLSCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVI B4DN35_HUMAN B4DN35_HUMAN ------------------------------------------------------------ RHG06_HUMAN RHG06_HUMAN EVAFYQLQQDCDLSCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVI B7Z8H7_HUMAN B7Z8H7_HUMAN EVAFYQLQQDCDLSCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVI Q59HG6_HUMAN Q59HG6_HUMAN EVAFYQLQQDCDLSCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVI MATCH CONSENSUS ?VA????????D????I?IP????K??KSLR?KLDS??KEK?KD?E??P??FG?PLSQVI

B1H1Q6_XENLA B1H1Q6_XENLA AQDRIERQRV-------FAVRDRRAC-TEVESSVLSFLV--HT-QR-------------- Q1ECW3_DANRE Q1ECW3_DANRE ANDLAYKQRQD------ALKESRRDC-LDLEASVLHFRA--EKWQQ--NGNRPLGKTVLS Q4STF4_TETNG Q4STF4_TETNG ANDRAFKRRQD------ALKESRRDC-LDLEASVLRFRA--EK-RQFFNGSKPPVSSPPA Q4S0D0_TETNG Q4S0D0_TETNG SNDRTLKQRHD------PQWEGYSDP-TELMLSYLHLTSSFKR-AN---------REFSS Q4T3X7_TETNG Q4T3X7_TETNG SNDRTLKQRHD------PQWEGYSDP-TELMLSYLHLTSSFKR-AN---------REFSS Q4RY11_TETNG Q4RY11_TETNG ANDRTHRQRQDGYRQDHLHREEQKDS-SDLVSSILQFAT--KRPSN---------KELSS A8WGG7_XENTR A8WGG7_XENTR ANDRAHKLRQD------SQREEQKDA-VDFVASILPFGS--KR-QN---------KELSS A2ALX6_MOUSE A2ALX6_MOUSE ANDRAYKLKQD------LQREEQKDASSDFVSSLLPFGN--KK-QN---------KELSS Q8C8B2_MOUSE Q8C8B2_MOUSE ANDRAYKLKQD------LQREEQKDASSDFVSSLLPFGN--KK-QN---------KELSS RHG06_MOUSE RHG06_MOUSE ANDRAYKLKQD------LQREEQKDASSDFVSSLLPFGN--KK-QN---------KELSS A2ALX7_MOUSE A2ALX7_MOUSE ANDRAYKLKQD------LQREEQKDASSDFVSSLLPFGN--KK-QN---------KELSS B4DN07_HUMAN B4DN07_HUMAN ANDRAYKLKQD------LQRDEQKDA-SDFVASLLPFGN--KR-QN---------KELSS A8KAL3_HUMAN A8KAL3_HUMAN ANDMAYKLKQD------LQRDEQKDA-SDFVASLLPFGN--KR-QN---------KELSS B4DN35_HUMAN B4DN35_HUMAN ------------------------------------------------------------ RHG06_HUMAN RHG06_HUMAN ANDRAYKLKQD------LQRDEQKDA-SDFVASLLPFGN--KR-QN---------KELSS B7Z8H7_HUMAN B7Z8H7_HUMAN ANDRAYKLKQD------LQRDEQKDA-SDFVASLLPFGN--KR-QN---------KELSS Q59HG6_HUMAN Q59HG6_HUMAN ANDRAYKLKQD------LQRDEQKDA-SDFVASLLPFGN--KR-QN---------KELSS MATCH CONSENSUS ANDR??K???D?????????????D???????S?L?F??????????????????????S

B1H1Q6_XENLA B1H1Q6_XENLA ----APPQGTSLELPLSPTFRDGVTRIRRRGALSVDSITELDNGDARLLEALQLSHSNEL Q1ECW3_DANRE Q1ECW3_DANRE PGAASSPVLELHSKPPSSAFMDNTSRTHRRGGMSVDSISDMVESQSRLLEALQLSHPNEL Q4STF4_TETNG Q4STF4_TETNG NSVAPAPGLDSQNKPTSPTFQDNTGR-QRRGGLSVDSISDLVESQSRLLEALQLSHPAEL Q4S0D0_TETNG Q4S0D0_TETNG SNSSLSS-SEAPNESPPISTADTAPRTCRRGGVSVDCITDLDDNQSRLLEALHLSVPAET Q4T3X7_TETNG Q4T3X7_TETNG SNSSLSS-SEAPNESPPISTADTAPRTCRRGGVSVDCITDLDDNQSRLLEALHLSVPAET Q4RY11_TETNG Q4RY11_TETNG SNSSLSSTSETANES-SPNTPEAAPRARRRGGMSVDSITDLDDNQSRLLEALQLSLPAET A8WGG7_XENTR A8WGG7_XENTR SNSSLSSTSETPNESTSPNTPEAAPRARRRGAMSVDSITDLDDNQSRLLEALQLSLPAET A2ALX6_MOUSE A2ALX6_MOUSE SNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQLSLPAEA Q8C8B2_MOUSE Q8C8B2_MOUSE SNSSPSSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQLSLPAEA RHG06_MOUSE RHG06_MOUSE SNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQLSLPAEA A2ALX7_MOUSE A2ALX7_MOUSE SNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQLSLPAEA B4DN07_HUMAN B4DN07_HUMAN SNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQLSLPAEA A8KAL3_HUMAN A8KAL3_HUMAN SNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQLSLPAEA B4DN35_HUMAN B4DN35_HUMAN ------------------------------------------------------------ RHG06_HUMAN RHG06_HUMAN SNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQLSLPAEA B7Z8H7_HUMAN B7Z8H7_HUMAN SNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQLSLPAEA Q59HG6_HUMAN Q59HG6_HUMAN SNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQLSLPAEA MATCH CONSENSUS ?????S???E??N???S????????R??RRG??SVDSITDLD??QSRLLEALQLS?PAE?

B1H1Q6_XENLA B1H1Q6_XENLA QDQR-----KEHSQ-RLSMNPVYKQVPRIVERCCSHLESY-------------------- Q1ECW3_DANRE Q1ECW3_DANRE EMKKA----AGRTQAKLSLNPIYRQVPRVVERCCNHIQTY-------------------- Q4STF4_TETNG Q4STF4_TETNG ELKKACPSDGRTPS-RLSLNPIYRQVPRVLERCCSHIEAHGEGTVHVHNDQGTQPSCTVL Q4S0D0_TETNG Q4S0D0_TETNG ACSRK----KRRDK-RLSLNPIYRQVPRVVELCCQHLEQH-------------------- Q4T3X7_TETNG Q4T3X7_TETNG ACSRK----KRRDK-RLSLNPIYRQVPRVVELCCQHLEQH-------------------- Q4RY11_TETNG Q4RY11_TETNG LNKKE----KHRDK-RLSLNPIYPQVPRVVDSCCQHIEKY-------------------- A8WGG7_XENTR A8WGG7_XENTR QSKKE----KERDK-KLSLNPIYRQVPRLVDSCCLHLEKY-----------------VIF A2ALX6_MOUSE A2ALX6_MOUSE QSKKE----KARDK-KLSLNPIYRQVPRLVDSCCQHLEKH-------------------- Q8C8B2_MOUSE Q8C8B2_MOUSE QSKKE----KARDK-KLSLNPIYRQVPRLVDSCCQHLEKH-------------------- RHG06_MOUSE RHG06_MOUSE QSKKE----KARDK-KLSLNPIYRQVPRLVDSCCQHLEKH-------------------- A2ALX7_MOUSE A2ALX7_MOUSE QSKKE----KARDK-KLSLNPIYRQVPRLVDSCCQHLEKH-------------------- B4DN07_HUMAN B4DN07_HUMAN QSKKE----KARDK-KLSLNPIYRQVPRLVDSCCQHLEKH-------------------- A8KAL3_HUMAN A8KAL3_HUMAN QSKKE----KARDK-KLSLNPIYRQVPRLVDSCCQHLEKH-------------------- B4DN35_HUMAN B4DN35_HUMAN ------------------------------------------------------------ RHG06_HUMAN RHG06_HUMAN QSKKE----KARDK-KLSLNPIYRQVPRLVDSCCQHLEKH-------------------- B7Z8H7_HUMAN B7Z8H7_HUMAN QSKKE----KARDK-KLSLNPIYRQVPRLVDSCCQHLEKH-------------------- Q59HG6_HUMAN Q59HG6_HUMAN QSKKE----KARDK-KLSLNPIYRQVPRLVDSCCQHLEKH-------------------- MATCH CONSENSUS ?????????K?R????LSLNPIYRQVPR?V??CC?H?E??????????????????????

B1H1Q6_XENLA B1H1Q6_XENLA --GLHTVGIFRIGSSKKRVEQLREEFAVSGDVLLGEDTCVHDVSALLKAFLRDLPDPVLP Q1ECW3_DANRE Q1ECW3_DANRE --GLQTLGIFRVGSSKKRVRQLREDFDNGIDVVLDEEHSVHDVAALLKEFLRDMPDPLLP Q4STF4_TETNG Q4STF4_TETNG FVGLQTVGIFRVGSSKKRVRQLREDFDQGVDVQLDEEHSVHDVAALLKEFLRDMPDPLLP Q4S0D0_TETNG Q4S0D0_TETNG --GLQTVGIFRIGSSRKRVRQLRKEFDRGWEVHLDEEHSVHDVAALLKEFLRDMPDPLLT Q4T3X7_TETNG Q4T3X7_TETNG --GLQTVGIFRIGSSRKRVRQLRKEFDRGWEVHLDEEHSVHDVAALLKEFLRDMPDPLLT Q4RY11_TETNG Q4RY11_TETNG --GLQTVGIFRVGSSKKRVRQLREEFDRGIDVQLDEEHSVHDVAALLKEFLRDMPDPLLT A8WGG7_XENTR A8WGG7_XENTR FTGLQTVGIFRVGSSKKRVRQLREEFDRGIDVALDEEHSVHDIAALLKEFLRDMPDPLLT A2ALX6_MOUSE A2ALX6_MOUSE --GLQTVGIFRVGSSKKRVRQTQE------------------------------------ Q8C8B2_MOUSE Q8C8B2_MOUSE --GLQTVGIFRVGSSKKRVRQTQE------------------------------------ RHG06_MOUSE RHG06_MOUSE --GLQTVGIFRVGSSKKRVRQLREEFDRGVDVCLEEEHSVHDVAALLKEFLRDMPDPLLT A2ALX7_MOUSE A2ALX7_MOUSE --GLQTVGIFRVGSSKKRVRQLREEFDRGVDVCLEEEHSVHDVAALLKEFLRDMPDPLLT B4DN07_HUMAN B4DN07_HUMAN --GLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLT A8KAL3_HUMAN A8KAL3_HUMAN --GLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLT B4DN35_HUMAN B4DN35_HUMAN -----------------------------------------------------MPDPLLT RHG06_HUMAN RHG06_HUMAN --GLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLT B7Z8H7_HUMAN B7Z8H7_HUMAN --GLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLT Q59HG6_HUMAN Q59HG6_HUMAN --GLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLT MATCH CONSENSUS ??GLQTVGIFR?GSSKKRVRQLRE?F?????V?L?E???VHD??ALLK?FLRDMPDPLL?

B1H1Q6_XENLA B1H1Q6_XENLA RELYSAFIHTAGLGKRERLNTLQLLIFALPMCNADTLLRILQLLHNVALHELDTTSSTGE Q1ECW3_DANRE Q1ECW3_DANRE RELYRAFLHANLLRGADQLSYLQQLLYLLPPCNCDTLLRLLTLLHTVQENANSSTGPNKQ Q4STF4_TETNG Q4STF4_TETNG RELYPAFLHANLLRGANQLQYLQHLLYLLPPCNCDTLLRLLSLLHTVQSFAQDAVGTNDE Q4S0D0_TETNG Q4S0D0_TETNG RELYTAFINTVSLTRADQQRALQLLIFLLPPCNSDTLQRLLRMLSTVAEHADD-SDCEGQ Q4T3X7_TETNG Q4T3X7_TETNG RELYTAFINTVSLTRADQQRALQLLIFLLPPCNSDTLQRLLRMLSTVAEHADD-SDCEGQ Q4RY11_TETNG Q4RY11_TETNG KELYTAFINTTLLDAEEQQHVAQLLIYLLPACNSDTLHRLLEFLSTVTDHAHDKQNKDGQ A8WGG7_XENTR A8WGG7_XENTR RELYTAFINTLLLDTDDQLCTLQLLIYLLPPCNCDTLHRLLQFLSTVANHADDTMDKDGQ A2ALX6_MOUSE A2ALX6_MOUSE ----------------------------------------------MKHHSE--AWKDGV Q8C8B2_MOUSE Q8C8B2_MOUSE ----------------------------------------------MKHHSE--AWKDGV RHG06_MOUSE RHG06_MOUSE RELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNVSKDGQ A2ALX7_MOUSE A2ALX7_MOUSE RELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNVSKDGQ B4DN07_HUMAN B4DN07_HUMAN RELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQ A8KAL3_HUMAN A8KAL3_HUMAN RELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQ B4DN35_HUMAN B4DN35_HUMAN RELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQ RHG06_HUMAN RHG06_HUMAN RELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQ B7Z8H7_HUMAN B7Z8H7_HUMAN RELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQ Q59HG6_HUMAN Q59HG6_HUMAN RELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQ MATCH : CONSENSUS RELY?AF?????L????Q???LQ?L??LLP?CN?DTL?RLL??L??V??HA?D?????G?

B1H1Q6_XENLA B1H1Q6_XENLA QVLGNKMSVTNLATVFGPNLLQNVKTPDSEMQ-----SFQDSSAQIRVTETLIQHYQDLY Q1ECW3_DANRE Q1ECW3_DANRE EISGNKMTAANLAVIFGPNLLQKERGSERELSPQALG-IEDSTAVISVTLMLIQNHQHLF Q4STF4_TETNG Q4STF4_TETNG E----------------------------------------------------------- Q4S0D0_TETNG Q4S0D0_TETNG KVLGNKMTTYNLATIFGPNLLHKQKNPEKEFTVQSFARAEESTAVISVVQKMISAHHSLF Q4T3X7_TETNG Q4T3X7_TETNG KVLGNKMTTYNLATIFGPNLLHKQKNPEKEFTVQSFARAEESTAVISVVQKMIAAHHSLF Q4RY11_TETNG Q4RY11_TETNG EVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAVIAVLQRMIASFQTLF A8WGG7_XENTR A8WGG7_XENTR EITGNKMTSLNLATIFGPNLLHKQKSSDKEFTVQSTARAEESTIIIAIVQKMIENFESLF A2ALX6_MOUSE A2ALX6_MOUSE GMKQLK--------------------------------------------------ENVW Q8C8B2_MOUSE Q8C8B2_MOUSE GMKQLK--------------------------------------------------ENVW RHG06_MOUSE RHG06_MOUSE EVTGNKMTSLNLATIFGPNLLHKQKSSDKEYSVQSSARAEESTAIIAVVQKMIENYEALF A2ALX7_MOUSE A2ALX7_MOUSE EVCCYK------ESVF------------------------------------------LW B4DN07_HUMAN B4DN07_HUMAN EVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMIENYEALF A8KAL3_HUMAN A8KAL3_HUMAN EVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMIENYEALF B4DN35_HUMAN B4DN35_HUMAN EVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMIENYEALF RHG06_HUMAN RHG06_HUMAN EVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMIENYEALF B7Z8H7_HUMAN B7Z8H7_HUMAN EVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMIENYEALF Q59HG6_HUMAN Q59HG6_HUMAN EVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMIENYEALF MATCH CONSENSUS ?????K?????????F??????????????????????????????????????????L?

B1H1Q6_XENLA B1H1Q6_XENLA T-----------------VPSHIHGDILISLLHSDPEVIDFLLRRKFSVVQILDG----- Q1ECW3_DANRE Q1ECW3_DANRE M-----------------VSAELQQEVLMSLIQTDPDVIDYLLRRKLSSSSLTVEPDSGG Q4STF4_TETNG Q4STF4_TETNG ------------------VSAELQQEVLMSLIQTDPDIIDYLLRRK-------------- Q4S0D0_TETNG Q4S0D0_TETNG M-----------------VPAELQNEVLMSLLETDCDVVDYLLRRKASQNLEPAGLQAGG Q4T3X7_TETNG Q4T3X7_TETNG M-----------------VPAELQNEVLMSLLETDCDVVDYLLRRKASQNLEPAGLQAGG Q4RY11_TETNG Q4RY11_TETNG TWLFSKGKQEILRCNPSWCLLNCRIEVLMSLLEKDPDVVDYLLRRKASQSS--DLLQTEE A8WGG7_XENTR A8WGG7_XENTR M-----------------VPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPELLRSES A2ALX6_MOUSE A2ALX6_MOUSE I-----------------CP---------------------------------------- Q8C8B2_MOUSE Q8C8B2_MOUSE I-----------------CP---------------------------------------- RHG06_MOUSE RHG06_MOUSE M-----------------VPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDILQTEV A2ALX7_MOUSE A2ALX7_MOUSE I-----------------VHP--------------------------------------- B4DN07_HUMAN B4DN07_HUMAN M-----------------VPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEV A8KAL3_HUMAN A8KAL3_HUMAN M-----------------VPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEV B4DN35_HUMAN B4DN35_HUMAN M-----------------VPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEV RHG06_HUMAN RHG06_HUMAN M-----------------VPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEV B7Z8H7_HUMAN B7Z8H7_HUMAN M-----------------VPPDLQNEVLISLLETDPDVVDYLLRRKASQSSTSSVL---- Q59HG6_HUMAN Q59HG6_HUMAN M-----------------VPPDLQNEVLISLLETDPDVVDYLLRRKASQSSTSSVL---- MATCH CONSENSUS ??????????????????V????????L?SL???D????D?LLRRK??????????????

B1H1Q6_XENLA B1H1Q6_XENLA ---------AAQTTLDMQQLKKDMRSSLLPHRPLQTLMEVLSIGVKSDFLDSRLSRRRPS Q1ECW3_DANRE Q1ECW3_DANRE RR-------DTQSSLDSMGQSSDDLSSREPLCPLYPEHSAIGSLSSEV------------ Q4STF4_TETNG Q4STF4_TETNG ------------------------------------------------------------ Q4S0D0_TETNG Q4S0D0_TETNG PFSVNVPLKERRLSSGSIQVSSGDVSPYDNNSPVLSDGLMGKYPEDSD------------ Q4T3X7_TETNG Q4T3X7_TETNG PFSVNVPLKERRLSSGSIQVSSGDVSPYDNNSPVLSDGLMEKYPEDSD------------ Q4RY11_TETNG Q4RY11_TETNG PFNLS----ECRSSSDSNKPSSGEVSPYDNNSPVMSER-----RAEPGSPDGEQPFHVPG A8WGG7_XENTR A8WGG7_XENTR SFSE-----GRHSSTDSNKASSGDVSPYDNNSPVLSER---AISRQEDSVNSEKLHKVPE A2ALX6_MOUSE A2ALX6_MOUSE ------------------------------------------------------------ Q8C8B2_MOUSE Q8C8B2_MOUSE ------------------------------------------------------------ RHG06_MOUSE RHG06_MOUSE SFSMG----GRHSSTDSNKASSGDISPYDNNSPVLSERSLLAMQEDRARGGSEKLYKVPE A2ALX7_MOUSE A2ALX7_MOUSE ------------------------------------------------------------ B4DN07_HUMAN B4DN07_HUMAN SFSVG----GRHSSTDSNKASSGDISPYDNNSPVLSERSLLAMQEDAAPGGSEKLYRVPG A8KAL3_HUMAN A8KAL3_HUMAN SFSVG----GRHSSTDSNKASSGDISPYDNNSPVLSERSLLAMQEDAAPGGSEKLYRVPG B4DN35_HUMAN B4DN35_HUMAN SFSVG----GRHSSTDSNKASSGDISPYDNNSPVLSERSLLAMQEDAAPGGSEKLYRVPG RHG06_HUMAN RHG06_HUMAN SFSVG----GRHSSTDSNKASSGDISPYDNNSPVLSERSLLAMQEDAAPGGSEKLYRVPG B7Z8H7_HUMAN B7Z8H7_HUMAN ------------------------------------------------------------ Q59HG6_HUMAN Q59HG6_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

B1H1Q6_XENLA B1H1Q6_XENLA RSQEDLTVCPSEPPTRTVIPSRP------------------------------------- Q1ECW3_DANRE Q1ECW3_DANRE -LLNVLHLNTNRKRSSEVPPKSIVKMRQFHSHHNLLSLTQSSSNAPSDERELQEQ----- Q4STF4_TETNG Q4STF4_TETNG ------------------------------------------------------------ Q4S0D0_TETNG Q4S0D0_TETNG ------------------------------------------------------------ Q4T3X7_TETNG Q4T3X7_TETNG ------------------------------------------------------------ Q4RY11_TETNG Q4RY11_TETNG QYSLVGQVAG--WNRDNMTNVSFSLDTMSEEHANIWGTWHTTLKPILKDQQFTGKSFTVG A8WGG7_XENTR A8WGG7_XENTR PHTLVGHLLS---KTKDSSSTQWCNKEVPEDNFNIWGTWHSTLKSTCKDQGMTDSYGNIY A2ALX6_MOUSE A2ALX6_MOUSE ------------------------------------------------------------ Q8C8B2_MOUSE Q8C8B2_MOUSE ------------------------------------------------------------ RHG06_MOUSE RHG06_MOUSE QYTLVGHLSSPKSKSRESSPGPRLGKEMSEEPFNIWGTWHSTLKSGSKDPGMTGSYGDIF A2ALX7_MOUSE A2ALX7_MOUSE ------------------------------------------------------------ B4DN07_HUMAN B4DN07_HUMAN QFMLVGHLSS--SKSRESSPGPRLGKDLSEEPFDIWGTWHSTLKSGSKDPGMTGTT---- A8KAL3_HUMAN A8KAL3_HUMAN QFMLVGHLSS--SKSRESSPGPRLGKDLSEEPFDIWGTWHSTLKSGSKDPGMTGSSGDIF B4DN35_HUMAN B4DN35_HUMAN QFMLVGHLSS--SKSRESSPGPRLGKDLSEEPFDIWGTWHSTLKSGSKDPGMTGSSGDIF RHG06_HUMAN RHG06_HUMAN QFMLVGHLSS--SKSRESSPGPRLGKDLSEEPFDIWGTWHSTLKSGSKDPGMTGSSGDIF B7Z8H7_HUMAN B7Z8H7_HUMAN ------------------------------------------------------------ Q59HG6_HUMAN Q59HG6_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

B1H1Q6_XENLA B1H1Q6_XENLA --------------------------------------------------RFLPLFSRAT Q1ECW3_DANRE Q1ECW3_DANRE --------------------------------------RQASSRHTCPEERLHFTLSRKD Q4STF4_TETNG Q4STF4_TETNG ------------------------------------------------------------ Q4S0D0_TETNG Q4S0D0_TETNG ------------------------------------------------------------ Q4T3X7_TETNG Q4T3X7_TETNG ------------------------------------------------------------ Q4RY11_TETNG Q4RY11_TETNG SQGNMSEGSSRSSQEGLDVD-----------GRQQATVQWTQTASGPSECRPHPPVTRVC A8WGG7_XENTR A8WGG7_XENTR ENSYLQQGQCCQLQGNHGQNWQQCKNSVKELENGKPTIRRSQTSSAIPEFRSHIPVTRVC A2ALX6_MOUSE A2ALX6_MOUSE ----------------------------------------------------------FC Q8C8B2_MOUSE Q8C8B2_MOUSE ----------------------------------------------------------FC RHG06_MOUSE RHG06_MOUSE ESSSLRPRPCSLSQGNLSLNWPRCQGSPTGLDSGTQVIRRTQTAATVEQCSVHLPVSRVC A2ALX7_MOUSE A2ALX7_MOUSE -------------------------------------------------------CFCYC B4DN07_HUMAN B4DN07_HUMAN -----------------------------------------------------PLLNISS A8KAL3_HUMAN A8KAL3_HUMAN ESSSLRAGPCSLSQGNLSPNWPRWQGSPAELDSDTQGARRTQAAAPATEGRAHPAVSRAC B4DN35_HUMAN B4DN35_HUMAN ESSSLRAGPCSLSQGNLSPNWPRWQGSPAELDSDTQGARRTQAAAPATEGRAHPAVSRAC RHG06_HUMAN RHG06_HUMAN ESSSLRAGPCSLSQGNLSPNWPRWQGSPAELDSDTQGARRTQAAAPATEGRAHPAVSRAC B7Z8H7_HUMAN B7Z8H7_HUMAN -----------------------------------------------------PAAVQAC Q59HG6_HUMAN Q59HG6_HUMAN -----------------------------------------------------PAAVQAC MATCH CONSENSUS ????????????????????????????????????????????????????????????

B1H1Q6_XENLA B1H1Q6_XENLA TSPRPHSLDTSSPVLSPSKLQIVTEEITKTLGFGKTAV---------------------- Q1ECW3_DANRE Q1ECW3_DANRE SGSQPQSPREKGIWVRQNSNASSTTSDDSKTPSNFWDFFTGKIPVVRRSPSLQNFFNDHS Q4STF4_TETNG Q4STF4_TETNG ------------------------------------------------------------ Q4S0D0_TETNG Q4S0D0_TETNG ------------------------------------------------------------ Q4T3X7_TETNG Q4T3X7_TETNG ------------------------------------------------------------ Q4RY11_TETNG Q4RY11_TETNG TSPNVQIGRP-RLQLNIKSLPRATGNGP-------------STNTRPQPGDSSPAALGDS A8WGG7_XENTR A8WGG7_XENTR SNPQTESGKR-NLEYSSRCDQHLSSSNAEDITNKDPSLSYIENKPKPLYLQHIDVSKNEA A2ALX6_MOUSE A2ALX6_MOUSE A----------------------------------------------------------- Q8C8B2_MOUSE Q8C8B2_MOUSE A----------------------------------------------------------- RHG06_MOUSE RHG06_MOUSE STPHIQDGSRGTRRPAASSDPFLSLNSTEDLAEGKEDVAWLQSQARPVYQRPQESGKDDR A2ALX7_MOUSE A2ALX7_MOUSE SI---------------------------------------------------------- B4DN07_HUMAN B4DN07_HUMAN QEDHRQ--------------------------------------------------KDLR A8KAL3_HUMAN A8KAL3_HUMAN STPHVQVAGK-AERPTARSEQYLTLSGAHDLSESELDVAGLQSRATPQCQRPHGSGRDDK B4DN35_HUMAN B4DN35_HUMAN STPHVQVAGK-AERPTARSEQYLTLSGAHDLSESELDVAGLQSRATPQCQRPHGSGRDDK RHG06_HUMAN RHG06_HUMAN STPHVQVAGK-AERPTARSEQYLTLSGAHDLSESELDVAGLQSRATPQCQRPHGSGRDDK B7Z8H7_HUMAN B7Z8H7_HUMAN ------------------------------------------------------------ Q59HG6_HUMAN Q59HG6_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

B1H1Q6_XENLA B1H1Q6_XENLA ------------------------------------------------------------ Q1ECW3_DANRE Q1ECW3_DANRE QSEKR------------------------------------------------------- Q4STF4_TETNG Q4STF4_TETNG ------------------------------------------------------------ Q4S0D0_TETNG Q4S0D0_TETNG ------------------------------------------------------------ Q4T3X7_TETNG Q4T3X7_TETNG ------------------------------------------------------------ Q4RY11_TETNG Q4RY11_TETNG HSPPPYHAHHRLAVSQS-------------------------SPHPATAQQPPLQQGRRN A8WGG7_XENTR A8WGG7_XENTR RLPPPYPGSAKQSAAQTHRSPVFSHEQGLWRLPKSETLAGTSLGRTQVTEQATCNRQISQ A2ALX6_MOUSE A2ALX6_MOUSE ------------------------------------------------------------ Q8C8B2_MOUSE Q8C8B2_MOUSE ------------------------------------------------------------ RHG06_MOUSE RHG06_MOUSE RPPPPYPGSGKPATTSAQLPLEPPLWRLQRHEEGSETAVEGGQQASGEHQTRPKKLSSAY A2ALX7_MOUSE A2ALX7_MOUSE ------------------------------------------------------------ B4DN07_HUMAN B4DN07_HUMAN LIFKIYP----------------------------------------------------- A8KAL3_HUMAN A8KAL3_HUMAN RPPPPYPGPGKPAAAAA--------WIQGPPEGVETPTDQGGQAAEREQQVTQKKLSSAN B4DN35_HUMAN B4DN35_HUMAN RPPPPYPGPGKPAAAAA--------WIQGPPEGVETPTDQGGQAAEREQQVTQKKLSSAN RHG06_HUMAN RHG06_HUMAN RPPPPYPGPGKPAAAAA--------WIQGPPEGVETPTDQGGQAAEREQQVTQKKLSSAN B7Z8H7_HUMAN B7Z8H7_HUMAN ---PQYPAS------------------------MFTP----------------------- Q59HG6_HUMAN Q59HG6_HUMAN ---PQYPAS------------------------MFTP----------------------- MATCH CONSENSUS ????????????????????????????????????????????????????????????

B1H1Q6_XENLA B1H1Q6_XENLA -------------------------------------------- Q1ECW3_DANRE Q1ECW3_DANRE -------------------------------------------- Q4STF4_TETNG Q4STF4_TETNG -------------------------------------------- Q4S0D0_TETNG Q4S0D0_TETNG -------------------------------------------- Q4T3X7_TETNG Q4T3X7_TETNG -------------------------------------------- Q4RY11_TETNG Q4RY11_TETNG NPAAMTEAQMAQQGAEWQDWQRDRWQIWQLLSSENADTLPETLV A8WGG7_XENTR A8WGG7_XENTR KIPDNNQNSRNLTEQDWQDWQRERWQIWELLSADNPDTLPETLV A2ALX6_MOUSE A2ALX6_MOUSE -------------------------------------------- Q8C8B2_MOUSE Q8C8B2_MOUSE -------------------------------------------- RHG06_MOUSE RHG06_MOUSE SLSASEQDKQNLGEASWLDWQRERWQIWELLSTDNPDALPETLV A2ALX7_MOUSE A2ALX7_MOUSE -------------------------------------------- B4DN07_HUMAN B4DN07_HUMAN -------------------------------------------- A8KAL3_HUMAN A8KAL3_HUMAN SLPAGEQDSPRLGGAGWLDWQRERWQIWELLSTDNPDALPETLV B4DN35_HUMAN B4DN35_HUMAN SLPAGEQDSPRLGDAGWLDWQRERWQIWELLSTDNPDALPETLV RHG06_HUMAN RHG06_HUMAN SLPAGEQDSPRLGDAGWLDWQRERWQIWELLSTDNPDALPETLV B7Z8H7_HUMAN B7Z8H7_HUMAN -------------------------------------------- Q59HG6_HUMAN Q59HG6_HUMAN -------------------------------------------- MATCH CONSENSUS ????????????????????????????????????????????


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