Alignment of the gene Family HBG079975 of HOVERGEN

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Isoforms are ON
A8R206_APOSY A8R206_APOSY ------------------------------------------------------------ GNAS1_RAT GNAS1_RAT GMLNCLHGNNMSGQHDIPPEVGDQPEQEPLEAQGAAAPGAGVGPAEEM----ETEPSNNE Q9QYZ0_MOUSE Q9QYZ0_MOUSE ------------------------------------------------------------ A8R218_MUSPA A8R218_MUSPA ------------------------------------------------------------ A8R213_MUSCR A8R213_MUSCR ------------------------------------------------------------ A8R216_MUSSI A8R216_MUSSI ------------------------------------------------------------ A2A606_MOUSE A2A606_MOUSE GMFNCLHGNNMSGQHDIPPEVGEQPEQEPLEAPGAAAPGAGAGPAEEMATEPDSEPSNNE GNAS1_MOUSE GNAS1_MOUSE GMFNCLHGNNMSGQHDIPPEVGEQPEQEPLEAPGAAAPGAGAGPAEEMATEPDSEPSNNE A8R220_MUSSP A8R220_MUSSP ------------------------------------------------------------ A8R208_9MURI A8R208_9MURI ------------------------------------------------------------ A8R211_9MURI A8R211_9MURI ------------------------------------------------------------ GNAS1_HUMAN GNAS1_HUMAN GVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEM----ETEPPHNE A5GFT9_PIG A5GFT9_PIG GVRNCLDGNNMSGQRNSPPEHGEQPEQPPLEAPGAAASGAGTGTAEEM----ETEPPHSE A5GFU0_PIG A5GFU0_PIG GVRNCLDGNNMSGQRNSPPEHGEQPEQPPLEAPGAAASGAGTGTAEEM----ETEPPHSE MATCH CONSENSUS ????????????????????????????????????????????????????????????

A8R206_APOSY A8R206_APOSY ------------------------------------------------------------ GNAS1_RAT GNAS1_RAT PIPDETDSEVCGPPEDSKSDIQSPSQAFEEVQVG--GDYSPPPEEAMPFEIQQPSLGDFW Q9QYZ0_MOUSE Q9QYZ0_MOUSE ------------------------------------------------------------ A8R218_MUSPA A8R218_MUSPA ------------------------------------------------------------ A8R213_MUSCR A8R213_MUSCR ------------------------------------------------------------ A8R216_MUSSI A8R216_MUSSI ------------------------------------------------------------ A2A606_MOUSE A2A606_MOUSE PVPDETGSEISGPPEDSKSDIQSPCQAFEEVRVG--GDYSPPPEEAMPFETQQPSLGDFW GNAS1_MOUSE GNAS1_MOUSE PVPDETGSEISGPPEDSKSDIQSPCQAFEEVRVG--GDYSPPPEEAMPFETQQPSLGDFW A8R220_MUSSP A8R220_MUSSP ------------------------------------------------------------ A8R208_9MURI A8R208_9MURI ------------------------------------------------------------ A8R211_9MURI A8R211_9MURI ------------------------------------------------------------ GNAS1_HUMAN GNAS1_HUMAN PIPVENDGEACGPPEVSRPNFQVLNPAFREAGAH--GSYSPPPEEAMPFEAEQPSLGGFW A5GFT9_PIG A5GFT9_PIG PIPIKTEGEASGPPEVSRPNLQSLGQAIKEAGAGDHGDYSPPPEEAMPFEVEQSGLGGFW A5GFU0_PIG A5GFU0_PIG PIPIKTEGEASGPPEVSRPNLQSLGQAIKEAGAGDHGDYSPPPEEAMPFEVEQSGLGGFW MATCH CONSENSUS ????????????????????????????????????????????????????????????

A8R206_APOSY A8R206_APOSY ------------------------------------------------------------ GNAS1_RAT GNAS1_RAT PTLEQPG-PSGTPSGIKAFNPAILEPGTPTGAHPGLGAYSPPPEEAMPFEFNEPAQEDRC Q9QYZ0_MOUSE Q9QYZ0_MOUSE ------------------------------------------------------------ A8R218_MUSPA A8R218_MUSPA ------------------------------------------------------------ A8R213_MUSCR A8R213_MUSCR ------------------------------------------------------------ A8R216_MUSSI A8R216_MUSSI ------------------------------------------------------------ A2A606_MOUSE A2A606_MOUSE PTLEQPG-PSGTPSGLQAFNPAILEPGTPTGASPGLGAYTPPPEEAMPFEFNEPAQGDHS GNAS1_MOUSE GNAS1_MOUSE PTLEQPG-PSGTPSGLQAFNPAILEPGTPTGASPGLGAYTPPPEEAMPFEFNEPAQGDHS A8R220_MUSSP A8R220_MUSSP ------------------------------------------------------------ A8R208_9MURI A8R208_9MURI ------------------------------------------------------------ A8R211_9MURI A8R211_9MURI ------------------------------------------------------------ GNAS1_HUMAN GNAS1_HUMAN PTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRGCS A5GFT9_PIG A5GFT9_PIG PAQEHPGDTPGAGAGLETSSPAIMEPRAFRETIPSLGSYSPPPEEAMPFEFEQPAQGGSS A5GFU0_PIG A5GFU0_PIG PAQEHPGDTPGAGAGLETSSPAIMEPRAFRETIPSLGSYSPPPEEAMPFEFEQPAQGGSS MATCH CONSENSUS ????????????????????????????????????????????????????????????

A8R206_APOSY A8R206_APOSY ------------------------------------------------------------ GNAS1_RAT GNAS1_RAT QPPLQVPDLAPGGPE-AWVSRALPAEPGNLGFENTGFREDYSPPPEESVPFQLDGEEFGG Q9QYZ0_MOUSE Q9QYZ0_MOUSE ------------------------------------------------------------ A8R218_MUSPA A8R218_MUSPA ------------------------------------------------------------ A8R213_MUSCR A8R213_MUSCR ------------------------------------------------------------ A8R216_MUSSI A8R216_MUSSI ------------------------------------------------------------ A2A606_MOUSE A2A606_MOUSE QPPLQVPDLAPGGPE-ALVPRALPAEPGNIRFENAGFREDYSPPPEESVPFQVGGEEFGG GNAS1_MOUSE GNAS1_MOUSE QPPLQVPDLAPGGPE-ALVPRALPAEPGNIRFENAGFREDYSPPPEESVPFQVGGEEFGG A8R220_MUSSP A8R220_MUSSP ------------------------------------------------------------ A8R208_9MURI A8R208_9MURI ------------------------------------------------------------ A8R211_9MURI A8R211_9MURI ------------------------------------------------------------ GNAS1_HUMAN GNAS1_HUMAN QLLLQVPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGD A5GFT9_PIG A5GFT9_PIG QPLLQVSDLAPGGPG-AGVFRAPPQEPRALRPANAGFRRGCSPPPEEDMPCEFDGAAFGD A5GFU0_PIG A5GFU0_PIG QPLLQVSDLAPGGPG-AGVFRAPPQEPRALRPANAGFRRGCSPPPEEDMPCEFDGAAFGD MATCH CONSENSUS ????????????????????????????????????????????????????????????

A8R206_APOSY A8R206_APOSY ------------------------------------------------------------ GNAS1_RAT GNAS1_RAT DSPPPGLPRVTPQIGIGGE--FPTVAVPSTLCLAPAANAPPLWVQGAIGRPFREAVRSP- Q9QYZ0_MOUSE Q9QYZ0_MOUSE ------------------------------------------------------------ A8R218_MUSPA A8R218_MUSPA ------------------------------------------------------------ A8R213_MUSCR A8R213_MUSCR ------------------------------------------------------------ A8R216_MUSSI A8R216_MUSSI ------------------------------------------------------------ A2A606_MOUSE A2A606_MOUSE DSPPPGLPRVIPQIGIGGE--FPTVAVPSALCLAPAENAPPLWVRGAIDRPFREAVRSPP GNAS1_MOUSE GNAS1_MOUSE DSPPPGLPRVIPQIGIGGE--FPTVAVPSALCLAPAENAPPLWVRGAIDRPFREAVRSPP A8R220_MUSSP A8R220_MUSSP ------------------------------------------------------------ A8R208_9MURI A8R208_9MURI ------------------------------------------------------------ A8R211_9MURI A8R211_9MURI ------------------------------------------------------------ GNAS1_HUMAN GNAS1_HUMAN DSPPPGLSRVIAQVDGSSQ--FAAVAASSAVRLTPAANAPPLWVPGAIGSPSQEAVRPPS A5GFT9_PIG A5GFT9_PIG DSPPPGLPRALPQIDGSGDSQIAPVAVPSEVLLAPAANEPPLWIPGSGGSPSREAVRPPP A5GFU0_PIG A5GFU0_PIG DSPPPGLPRALPQIDGSGDSQIAPVAVPSEVLLAPAANEPPLWIPGSGGSPSREAVRPPP MATCH CONSENSUS ????????????????????????????????????????????????????????????

A8R206_APOSY A8R206_APOSY --------MEITRPQLEIGRASIGVDDDIAVNMDSPPIASVGPPIEVSGAPDKSQRT--E GNAS1_RAT GNAS1_RAT NFAYDISPMEITRPLLEIGRASTGVDDDTAVNMDSPPIASDGPPIEVSGAPVKSEHA--K Q9QYZ0_MOUSE Q9QYZ0_MOUSE --------MEITRPLLEIGRASIGVDDDTAVNMDSPPIASDGPPIEVSGAPDKSECA--E A8R218_MUSPA A8R218_MUSPA --------MEITRPLLEIGRASIGVDDDTAVNMDSPPIASDGPPIEVSGAPDKSECA--E A8R213_MUSCR A8R213_MUSCR --------MEITRPLLEIGRASIGVDDDTAVNMDSPPIARDGPPIEVSGAPDKSECA--E A8R216_MUSSI A8R216_MUSSI --------MEITRPLLEIGRASIGVDDDTAVNMDSPPIASDGPPIEVSGAPDKSECA--E A2A606_MOUSE A2A606_MOUSE NFACDSPPMEITRPLLEIGRASIGVDDDTAVNMDSPPIASDGPPIEVSGAPDKSECA--E GNAS1_MOUSE GNAS1_MOUSE NFACDSPPMEITRPLLEIGRASIGVDDDTAVNMDSPPIASDGPPIEVSGAPDKSECA--E A8R220_MUSSP A8R220_MUSSP --------MEITRPLLEIGRASIGVDDDTAVNMDSPPIASDGPPIEVSGAPDKSECA--E A8R208_9MURI A8R208_9MURI --------MEITRPLLEIGRASTGVDDDTAVNMDSPPIASDGPPIEVSGAPDKSERT--E A8R211_9MURI A8R211_9MURI --------MEITRPLLEIGRASIGVDDDTAVNMDSPPIASDGPPIEVSGAPDKSELT--E GNAS1_HUMAN GNAS1_HUMAN NFTGSSPWMEISGPPFEIGSAPAGV-DDTPVNMDSPPIALDGPPIKVSGAPDKRERA--E A5GFT9_PIG A5GFT9_PIG HFAGDSPPMEISGPQREAGIAPDGV-DDAPVNVDSPPVAPDSPPIEVSGAPVKREPAEGE A5GFU0_PIG A5GFU0_PIG HFAGDSPPMEISGPQREAGIAPDGV-DDAPVNVDSPPVAPDSPPIEVSGAPVKREPAEGE MATCH ***: * * * *. ** ** .**:****:* .***:***** * : : : CONSENSUS ????????MEI??P??EIG?A??GV?DD??VNMDSPPIA?DGPPIEVSGAP?K?E????E

A8R206_APOSY A8R206_APOSY RPPVEREAAEMEGSP-TTAAAVEGKVPSPEREDRSSTEPEAMDAKPAPAAQADDDITGSE GNAS1_RAT GNAS1_RAT RPPLERQAAETGNSPISSTTAEEAKVPSLERGEGSPTQPETVHIKPAPVAE-----SGTD Q9QYZ0_MOUSE Q9QYZ0_MOUSE RPPVEREAAEMEGSP-TTATAVEGKVPSPERGDGSSTQPEAMDAKPAPAAQAVS--TGSD A8R218_MUSPA A8R218_MUSPA RPPVEREAAEMEGSP-TTAAAVEGKVPSPERGDGSSTQPEAMDAKPAPAAQAVS--TGSD A8R213_MUSCR A8R213_MUSCR RPPVEQEAAEMEGSP-TTATAVEGKVPSPERGDGSSTQPEAMDAKPAPAAQAVS--TGSD A8R216_MUSSI A8R216_MUSSI RPPVEREAAEMEGSP-TTATAVEGKVPSPEREDGSSTQPEAMDAKPAPDAQAVS--TGSD A2A606_MOUSE A2A606_MOUSE RPPVEREAAEMEGSP-TTATAVEGKVPSPERGDGSSTQPEAMDAKPAPAAQAVS--TGSD GNAS1_MOUSE GNAS1_MOUSE RPPVEREAAEMEGSP-TTATAVEGKVPSPERGDGSSTQPEAMDAKPAPAAQAVS--TGSD A8R220_MUSSP A8R220_MUSSP RPPVEREAAEMEGSP-TTATAVEGKVPSPERGDGSSTQPEAMDAKPAPAAQAVS--TGSD A8R208_9MURI A8R208_9MURI RPPVEREAAEKERSS-ITATTMEGKVLSLEKEEGFSTQPEAMDAQPAPAAQAVS--TGSD A8R211_9MURI A8R211_9MURI RPPFEREAAETERSP-ITATTMEGKVPSLEREEGSSTQPEAMDAQPAPAAQAVS--TGSD GNAS1_HUMAN GNAS1_HUMAN RPPVEEEAAEMEG---AADAAEGGKVPSPGYG--------------SPAA---------- A5GFT9_PIG A5GFT9_PIG RPPAEGEEADMEGGS-ASAAAEGSKVPDP--GDG------------APAA---------- A5GFU0_PIG A5GFU0_PIG RPPAEGEEADMEGGS-ASAAAEGSKVPDP--GDG------------APAA---------- MATCH *** * : *: : :: .** . :* * CONSENSUS RPP?E?EAAE?E??????A?A???KVPS?????G????????????APAA??????????

A8R206_APOSY A8R206_APOSY ADGGSPDAAMLGVSDSDLGEGDTDPGTPSDLQSDPEEVGEAPAVRDEPDGGTAPVAP--- GNAS1_RAT GNAS1_RAT SSKADPDSATHAVLQIGPEEVGGVPTMPTDLP--PASEDAGPDVRAEPDGGTAPATPAES Q9QYZ0_MOUSE Q9QYZ0_MOUSE AGA-PTDSAMLTDSQSDAGEDGTAPGTPSDLQSDPEELEEAPAVRADPDGGAAPVAP--- A8R218_MUSPA A8R218_MUSPA AGGAPLDSTMLTDSQSDAGEDGTAPGTPSDLQSDPEELEEAPAVRAEPDGGAAPVAP--- A8R213_MUSCR A8R213_MUSCR AGG-APDSAMLTDSQSDTGEDGTAPGTPSDLQSDPEELEEAPAVRADPDGGAAPVAP--- A8R216_MUSSI A8R216_MUSSI AGA-PADSAMLTDSQSDAGEDGTAPGTPSDLQSDPEELEEAPAVRADPDGGAAPVAP--- A2A606_MOUSE A2A606_MOUSE AGA-PTDSAMLTDSQSDAGEDGTAPGTPSDLQSDPEELEEAPAVRADPDGGAAPVAP--- GNAS1_MOUSE GNAS1_MOUSE AGA-PTDSAMLTDSQSDAGEDGTAPGTPSDLQSDPEELEEAPAVRADPDGGAAPVAP--- A8R220_MUSSP A8R220_MUSSP AGA-PTDSAMLTDSQSDAGEDGTAPGTPSDLQSDPEELEEAPAVRADPDGGAAPVAP--- A8R208_9MURI A8R208_9MURI ASGAPPDAEMLTDTQSDAEEVGTTPGTSSDIQSDPEEDEEAPAVRDEPDGGAAPVAP--- A8R211_9MURI A8R211_9MURI AGGAPPDAEMLTDTQSDAGEVGTTPGTSSDLQSDSEEVEEAPAVRDEPDGGAAPVAP--- GNAS1_HUMAN GNAS1_HUMAN ---------------------GAASADTAA--------RAAPAAPADPDSGATPEDP--- A5GFT9_PIG A5GFT9_PIG ---------------------GAAPASPAA--------GAAPSVPASPAAGAAPEAP--- A5GFU0_PIG A5GFU0_PIG ---------------------GAAPASPAA--------GAAPSVPASPAAGAAPEAP--- MATCH . . .: .* . .* .*::* * CONSENSUS ?????????????????????G??P???????????????AP?V???PD?GAAP?AP???

A8R206_APOSY A8R206_APOSY -----------ATPA------ESEGARDPAA----EPASEAVPATTAESASGAAPITQVE GNAS1_RAT GNAS1_RAT EDNREPAAAAAAEPA---AEPAAEPAAEPAAEPAAEPAAEAVPDTEAESASGAVPDTQEE Q9QYZ0_MOUSE Q9QYZ0_MOUSE -----------ATPA----ESESEGSRDPAA----EPASEAVPATTAESASGAAPVTQVE A8R218_MUSPA A8R218_MUSPA -----------ATPA----ESESEGSRDPAA----EPASEAVPATTAESASGAAPVTQVE A8R213_MUSCR A8R213_MUSCR -----------ATPA----ESESEGSRDPAAA---EPASEAVPATTAESASGAAPVTQVE A8R216_MUSSI A8R216_MUSSI -----------ATPA----ESESEGSRDPAA----EPASEAVPATTAESASGAAPVTQVE A2A606_MOUSE A2A606_MOUSE -----------ATPA----ESESEGSRDPAA----EPASEAVPATTAESASGAAPVTQVE GNAS1_MOUSE GNAS1_MOUSE -----------ATPA----ESESEGSRDPAA----EPASEAVPATTAESASGAAPVTQVE A8R220_MUSSP A8R220_MUSSP -----------ATPA----ESESEGSRDPAA----EPASEAVPATTAESASGAAPVTQVE A8R208_9MURI A8R208_9MURI -----------ATPAESESESESEGVRDPAAEPASEPASEAVPATTAESASGAAPVTQVE A8R211_9MURI A8R211_9MURI -----------ATPA----EPEGEGVRDPAA----EPASEAVPATTAESASGAAPVTQVE GNAS1_HUMAN GNAS1_HUMAN -----------DSGT--------------------APADPDSGAFAADPDSGAAP----- A5GFT9_PIG A5GFT9_PIG -----------AEGA--------------------APATPDSP------ASGAAP----- A5GFU0_PIG A5GFU0_PIG -----------AEGA--------------------APATPDSP------ASGAAP----- MATCH : ** ***.* CONSENSUS ???????????A??A?????????????????????PA????P???A??ASGAAP?????

A8R206_APOSY A8R206_APOSY PAAAAGSATTAEPAARAAPIAPKEPFTRAVPSARAHPAAGAVPGAPAMSASARAAAARAA GNAS1_RAT GNAS1_RAT PAAAAASATPAEPAARAAPVTPTEPATRAVPSARAHPAAGAVPGASAMSAAARAAAARAA Q9QYZ0_MOUSE Q9QYZ0_MOUSE PAAAAVSATLAEPAARAAPITPKEPTTRAVPSARAHPAAGAVPGAPAMSASARAAAARAA A8R218_MUSPA A8R218_MUSPA PAAAAVSATLAEPAARAAPITPTEPAIRAVPSARAHPAAGAVPGAPAMSASARAAAARAA A8R213_MUSCR A8R213_MUSCR PAAAAVSATLAEPAARAVPITPTEPATRAVPSARAHPAAGAVPGAPAMSASARAAAARAA A8R216_MUSSI A8R216_MUSSI PAAAAVSAILAEPAARAAPITPKEPATRAVPSARAHPAAGAVPGAPAMSASARAAAARAA A2A606_MOUSE A2A606_MOUSE PAAAAVSATLAEPAARAAPITPKEPTTRAVPSARAHPAAGAVPGAPAMSASARAAAARAA GNAS1_MOUSE GNAS1_MOUSE PAAAAVSATLAEPAARAAPITPKEPTTRAVPSARAHPAAGAVPGAPAMSASARAAAARAA A8R220_MUSSP A8R220_MUSSP PAAAAVSATLAEPAARAAPITPKEPATRAVPSARAHPAAGAVPGAPAMSASARAAAARAA A8R208_9MURI A8R208_9MURI PAAAAVSATPAEP--RAAPITPTERSTRAIPSARAHPAAGAVPGAPAMSASARAAAARAA A8R211_9MURI A8R211_9MURI PAAAAVSATPAEPAARAAPITPTEPSTRAVPSARAHPAAGAVPGAPAMSASARAAAARAA GNAS1_HUMAN GNAS1_HUMAN -------AAPADPDSGAAPDAPADPDSGAAPDAPADPDAGAAPEAPAAPAAAE------- A5GFT9_PIG A5GFT9_PIG -------AAPDAPAAGAAPAAPAAPAARAAPAVPA------------------------- A5GFU0_PIG A5GFU0_PIG -------AAPDAPAAGAAPAAPAAPAARAAPAVPA------------------------- MATCH * * *.* :* * * . * CONSENSUS ???????A??A?PAA?AAP??P??P??RA?P?A?A?P?AGA?P?A?A??A?A????????

A8R206_APOSY A8R206_APOSY YAGPLVWGAR----SLSATPAARASLPARAAAAARAASAARAVIAGQSISAAPSRA---- GNAS1_RAT GNAS1_RAT YAGPLVWGAR----SLSATPAARASLPARAAAAARAASAARAVAAGRSASAAPSRA---- Q9QYZ0_MOUSE Q9QYZ0_MOUSE YAGPLVWGARYSRYSQLLPPLGHPFLPRRAA--ARQASAARAVAAGRSA-LPPHRA---- A8R218_MUSPA A8R218_MUSPA YAGPLVWGAR----SLSATPAARASLPARAAAAARAASAARAVAAGRSASAAPSRA---- A8R213_MUSCR A8R213_MUSCR YAGPLVWGAR----SLSATPAARASLPARAAAAARAASAARAVAAGRSASAAPSRA---- A8R216_MUSSI A8R216_MUSSI YAGPLVWGAR----SLSATPAARASLPARAAAAARAASAARAVAAGRSASAAPSRA---- A2A606_MOUSE A2A606_MOUSE YAGPLVWGAR----SLSATPAARASLPARAAAAARAASAARAVAAGRSASAAPSRA---- GNAS1_MOUSE GNAS1_MOUSE YAGPLVWGAR----SLSATPAARASLPARAAAAARAASAARAVAAGRSASAAPSRA---- A8R220_MUSSP A8R220_MUSSP YAGPLVWGAR----SLSATPAARASLPARAAAAARAASAARAVAAGRSASAAPSRA---- A8R208_9MURI A8R208_9MURI YAGPLVWGAR----SLSATPAARAFLPARAAAAARAASAARAVAAGRSISAASSRA---- A8R211_9MURI A8R211_9MURI YAGPLVWGAR----SLSATPAARASLPARAAAAARAASAARAVAAGRSASAAPSRA---- GNAS1_HUMAN GNAS1_HUMAN --------TR----AAHVAPAA----PDAGAPTAPAASATRAAQVRRAASAAPASGARRK A5GFT9_PIG A5GFT9_PIG --------AR----AASAAPA------ARAAPAARAASASRAV---PDYGARPKIG---- A5GFU0_PIG A5GFU0_PIG --------AR----AASAAPA------ARAAPAARAASASRAV---PDYGARPKIG---- MATCH :* : .* .* * ***:**. . . CONSENSUS ????????AR??????SA?PA?????PARAA?AARAASA?RAV???????A?P???????

A8R206_APOSY A8R206_APOSY -HLRPPSPEIQVADPPTPRPPPRPSAWPDKYEQRGRSCCR---YETATGICEIESSSDES GNAS1_RAT GNAS1_RAT -HLRPPSPEIQVADPPTPRPAPRPSAWPDKYE-RGRSCCR---YEAASGICEIESSSDES Q9QYZ0_MOUSE Q9QYZ0_MOUSE -HL-DPQPRDQVADPPTPRPPPRPTAWPDKYE-RGRSCCR---YEASSGICEIESSSDES A8R218_MUSPA A8R218_MUSPA -HLRPPSPEIQVADPPTPRPPPRPTAWPDKYE-RGRSCCR---YEASSGICEIESSSDES A8R213_MUSCR A8R213_MUSCR -HLRPPSPEIQVADPPTPRPPPRPTAWPDKYE-RGRSCCR---YEASSGICEIESSSDES A8R216_MUSSI A8R216_MUSSI -HLRPPSPEIQVADPPTPRPPPRPTAWPDKYE-RGRSCCR---YEASSGICEIESSSDES A2A606_MOUSE A2A606_MOUSE -HLRPPSPEIQVADPPTPRPPPRPTAWPDKYE-RGRSCCR---YEASSGICEIESSSDES GNAS1_MOUSE GNAS1_MOUSE -HLRPPSPEIQVADPPTPRPPPRPTAWPDKYE-RGRSCCR---YEASSGICEIESSSDES A8R220_MUSSP A8R220_MUSSP -HLRPPSPEIQVADPPTPRPPPRPTAWPDKYE-RGRSCCR---YEASSGICEIESSSDES A8R208_9MURI A8R208_9MURI -HLRPPSPEIQVADPPTPRPAPRPTAWPDNYE-RGRSCCR---YEASSGICEIESSSDES A8R211_9MURI A8R211_9MURI -HLRPPSPEIQVADPPTPRPAPRPTAWPDNYE-RGRSCCR---YEASSGICEIESSSDES GNAS1_HUMAN GNAS1_HUMAN IHLRPPSPEIQAADPPTPRP-TRASAWRGKSE---SSRGRRVYYDEGVASSDDDSSGDES A5GFT9_PIG A5GFT9_PIG -FLRPPSPEIQAADPPTPQP-PRAYAWRGRSE---RCCER---YDDEISVS--SDSGDES A5GFU0_PIG A5GFU0_PIG -FLRPPSPEIQAADPPTPQP-PRAYAWRGRSE---RCCER---YDDEISVS--SDSGDES MATCH .* *.*. *.******:* .*. ** .. * . * *: . . ..*.*** CONSENSUS ?HLRPPSPEIQ?ADPPTPRP?PR??AW????E???RSC?R???Y??????????SS?DES

A8R206_APOSY A8R206_APOSY EEGATGCFQWLL-RRNRRPGLPRSHTVGSNPIRNFFTRAFGSCFGLSECIRSR-SLSPRK GNAS1_RAT GNAS1_RAT EEGATGCFQWLL-RRNRRPGQPRSHTVGSNPVRNFFARAFGSCFGLSECTRSR-SLSPGK Q9QYZ0_MOUSE Q9QYZ0_MOUSE EEGATGCFQWLL-RRNRRPGLPRSHTVGSNPVRNFFTRAFGSCFGLSECTRSR-SLSPGK A8R218_MUSPA A8R218_MUSPA EEGATGCFQWLL-RRNRRPGLPRSHTVGSNPVRNFFTRAFGSCFGLSECTRSR-SLSPGK A8R213_MUSCR A8R213_MUSCR EEGATGCFQWLL-RRNRRPGLPRSHTVGSNPVRNFFTRAFGSCFGLSECTRSR-SLSPGK A8R216_MUSSI A8R216_MUSSI EEGATGCFQWLL-RRNRRPGLPRSHTVGSNPVRNFFTRAFGSCFGLSECTRSR-SLSPGK A2A606_MOUSE A2A606_MOUSE EEGATGCFQWLL-RRNRRPGLPRSHTVGSNPVRNFFTRAFGSCFGLSECTRSR-SLSPGK GNAS1_MOUSE GNAS1_MOUSE EEGATGCFQWLL-RRNRRPGLPRSHTVGSNPVRNFFTRAFGSCFGLSECTRSR-SLSPGK A8R220_MUSSP A8R220_MUSSP EEGATGCFQWLL-RRNRRPGLPRSHTVGSNPVRNFFTRAFGSCFGLSECTRSR-SLSPGK A8R208_9MURI A8R208_9MURI EEGATGCFQWLL-RRNRRPGLPRSHTIESNPVRKFFTRVFRRCFKVSACARSR-SHSPTK A8R211_9MURI A8R211_9MURI EEGATGCFQWLL-RRNRRPGLPRSHTVGSNPVRKFFTRAFRSCFNLSACARSR-SLSPKK GNAS1_HUMAN GNAS1_HUMAN DDGTSGCLRWFQHRRNRRRRKPQ-----RNLLRNFLVQAFGGCFGRSESPQPKASRSLKV A5GFT9_PIG A5GFT9_PIG DDGTFGCRRWFLSRRNRRRRKPR-----RNLLRNFLVQAFGGCFCGSESPQSGGSVGPKV A5GFU0_PIG A5GFU0_PIG DDGTFGCRRWFLSRRNRRRRKPR-----RNLLRNFLVQAFGGCFCGSESPQSGGSVGPKV MATCH ::*: ** :*: ***** *: * :*:*:.:.* ** * . :. * . CONSENSUS ??G??GC??W?L?RRNRR???PR??????N??RNF???AFG?CF??SE???S??S?SP??

A8R206_APOSY A8R206_APOSY AKDSMAERRKQLRKEVIEMREQMRAEKKRSKEIDKQLEEEKMDYMCTHRLLLL------- GNAS1_RAT GNAS1_RAT AKDPMEERRKQMRKEAMEMREQKRADKKRSKLIDKQLEEEKMDYMCTHRLLLL------- Q9QYZ0_MOUSE Q9QYZ0_MOUSE AKDPMEERRKQMRKEAIEMREQKRADKKRSKLIDKQLEEEKMDYMCTHRLLLL------- A8R218_MUSPA A8R218_MUSPA AKDPMEERRKQMRKEAIEMREQKRADKKRSKLIDKQLEEEKMDYMCTHRLLLL------- A8R213_MUSCR A8R213_MUSCR AKDPMEERRKQMRKEAIEMREQKRADKKRSKLIDKQLEEEKMDYMCTHRLLLL------- A8R216_MUSSI A8R216_MUSSI AKDPMEERRKQMRKEAIEMREQKRADKKRSKLIDKQLEEEKMDYMCTHRLLLL------- A2A606_MOUSE A2A606_MOUSE AKDPMEERRKQMRKEAIEMREQKRADKKRSKLIDKQLEEEKMDYMCTHRLLLL------- GNAS1_MOUSE GNAS1_MOUSE AKDPMEERRKQMRKEAIEMREQKRADKKRSKLIDKQLEEEKMDYMCTHRLLLL------- A8R220_MUSSP A8R220_MUSSP AKDPMEERRKQMRKEAIEMREQKRADKKRSKLIDKQLEEEKMDYMCTHRLLLL------- A8R208_9MURI A8R208_9MURI IKDQMEERRKQMRKEAVELRERRRADKKRSKIIDKQLEEEKMDYMCTHRLLLL------- A8R211_9MURI A8R211_9MURI VKNQMEERRKQMRKEAMELREQKRADKKRSKLIDKQLEEEKMDYMCTHRLLLL------- GNAS1_HUMAN GNAS1_HUMAN KKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLL------- A5GFT9_PIG A5GFT9_PIG KKVPLAEKRRQTRKESIEKRAQKRAEKRRSKLIEKQLQNEKMGYMCTHRLLLLGGKVVPY A5GFU0_PIG A5GFU0_PIG KKVPLAEKRRQTRKESIEKRAQKRAEKRRSKLIEKQLQNEKMGYMCTHRLLLL------- MATCH * : *:*:* *** :* * : **:*:*** *:***::***.********** CONSENSUS ?K????E?R?Q?RKE??E?R?QKRA?KKRSKLIDKQL??EKM?YMCTHRLLLL???????

A8R206_APOSY A8R206_APOSY ------------------------------------------------------------ GNAS1_RAT GNAS1_RAT ---------------------------------GAGESGKSTIVKQMRILHVNGFNGEGG Q9QYZ0_MOUSE Q9QYZ0_MOUSE ------------------------------------------------------------ A8R218_MUSPA A8R218_MUSPA ------------------------------------------------------------ A8R213_MUSCR A8R213_MUSCR ------------------------------------------------------------ A8R216_MUSSI A8R216_MUSSI ------------------------------------------------------------ A2A606_MOUSE A2A606_MOUSE --------------------------------------GRKVVPSDTE-----------G GNAS1_MOUSE GNAS1_MOUSE ---------------------------------GAGESGKSTIVKQMRILHVNGFNGEGG A8R220_MUSSP A8R220_MUSSP ------------------------------------------------------------ A8R208_9MURI A8R208_9MURI ------------------------------------------------------------ A8R211_9MURI A8R211_9MURI ------------------------------------------------------------ GNAS1_HUMAN GNAS1_HUMAN ---------------------------------GAGESGKSTIVKQMRILHVNGFNGEGG A5GFT9_PIG A5GFT9_PIG NTEGRFQLDKPGPAIVRRRRVVGWGTARKAGDSGAGESGKSTIVKQMRILHVNGFNGEGG A5GFU0_PIG A5GFU0_PIG ---------------------------------GAGESGKSTIVKQMRILHVNGFNGEGG MATCH CONSENSUS ????????????????????????????????????????????????????????????

A8R206_APOSY A8R206_APOSY ------------------------------------------------------------ GNAS1_RAT GNAS1_RAT EEDPQAARSNSDGEKATKVQDIKNN-----LKEAIETIVAAMSNLVPPVELANPENQFRV Q9QYZ0_MOUSE Q9QYZ0_MOUSE ------------------------------------------------------------ A8R218_MUSPA A8R218_MUSPA ------------------------------------------------------------ A8R213_MUSCR A8R213_MUSCR ------------------------------------------------------------ A8R216_MUSSI A8R216_MUSSI ------------------------------------------------------------ A2A606_MOUSE A2A606_MOUSE RYRPEASASASDRRLDRRGREVSPELLGWALRGSPGSIVRDRGGLGPS------------ GNAS1_MOUSE GNAS1_MOUSE EEDPQAARSNSDGEKATKVQDIKNN-----LKEAIETIVAAMSNLVPPVELANPENQFRV A8R220_MUSSP A8R220_MUSSP ------------------------------------------------------------ A8R208_9MURI A8R208_9MURI ------------------------------------------------------------ A8R211_9MURI A8R211_9MURI ------------------------------------------------------------ GNAS1_HUMAN GNAS1_HUMAN EEDPQAARSNSDGEKATKVQDIKNN-----LKEAIETIVAAMSNLVPPVELANPENQFRV A5GFT9_PIG A5GFT9_PIG EEDPQAARSNSDGEKATKVQDIKNN-----LKEAIETIVAAMSNLVPPVELANPENQFRV A5GFU0_PIG A5GFU0_PIG EEDPQAARSNSDGEKATKVQDIKNN-----LKEAIETIVAAMSNLVPPVELANPENQFRV MATCH CONSENSUS ????????????????????????????????????????????????????????????

A8R206_APOSY A8R206_APOSY ------------------------------------------------------------ GNAS1_RAT GNAS1_RAT DYILSVMNVPNFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQA Q9QYZ0_MOUSE Q9QYZ0_MOUSE ------------------------------------------------------------ A8R218_MUSPA A8R218_MUSPA ------------------------------------------------------------ A8R213_MUSCR A8R213_MUSCR ------------------------------------------------------------ A8R216_MUSSI A8R216_MUSSI ------------------------------------------------------------ A2A606_MOUSE A2A606_MOUSE ----------------------------------------------------------GC GNAS1_MOUSE GNAS1_MOUSE DYILSVMNVPNFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQA A8R220_MUSSP A8R220_MUSSP ------------------------------------------------------------ A8R208_9MURI A8R208_9MURI ------------------------------------------------------------ A8R211_9MURI A8R211_9MURI ------------------------------------------------------------ GNAS1_HUMAN GNAS1_HUMAN DYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQA A5GFT9_PIG A5GFT9_PIG DYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQA A5GFU0_PIG A5GFU0_PIG DYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQA MATCH CONSENSUS ????????????????????????????????????????????????????????????

A8R206_APOSY A8R206_APOSY ------------------------------------------------------------ GNAS1_RAT GNAS1_RAT DYVPSDQDLPRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVV Q9QYZ0_MOUSE Q9QYZ0_MOUSE ------------------------------------------------------------ A8R218_MUSPA A8R218_MUSPA ------------------------------------------------------------ A8R213_MUSCR A8R213_MUSCR ------------------------------------------------------------ A8R216_MUSSI A8R216_MUSSI ------------------------------------------------------------ A2A606_MOUSE A2A606_MOUSE APPPRLARLLRLRQLVVGVCWCPFSV---------------------------------- GNAS1_MOUSE GNAS1_MOUSE DYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVV A8R220_MUSSP A8R220_MUSSP ------------------------------------------------------------ A8R208_9MURI A8R208_9MURI ------------------------------------------------------------ A8R211_9MURI A8R211_9MURI ------------------------------------------------------------ GNAS1_HUMAN GNAS1_HUMAN DYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVV A5GFT9_PIG A5GFT9_PIG DYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVV A5GFU0_PIG A5GFU0_PIG DYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVV MATCH CONSENSUS ????????????????????????????????????????????????????????????

A8R206_APOSY A8R206_APOSY ------------------------------------------------------------ GNAS1_RAT GNAS1_RAT ASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKI Q9QYZ0_MOUSE Q9QYZ0_MOUSE ------------------------------------------------------------ A8R218_MUSPA A8R218_MUSPA ------------------------------------------------------------ A8R213_MUSCR A8R213_MUSCR ------------------------------------------------------------ A8R216_MUSSI A8R216_MUSSI ------------------------------------------------------------ A2A606_MOUSE A2A606_MOUSE ------------------------------------------------------------ GNAS1_MOUSE GNAS1_MOUSE ASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKI A8R220_MUSSP A8R220_MUSSP ------------------------------------------------------------ A8R208_9MURI A8R208_9MURI ------------------------------------------------------------ A8R211_9MURI A8R211_9MURI ------------------------------------------------------------ GNAS1_HUMAN GNAS1_HUMAN ASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKI A5GFT9_PIG A5GFT9_PIG ASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKI A5GFU0_PIG A5GFU0_PIG ASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKI MATCH CONSENSUS ????????????????????????????????????????????????????????????

A8R206_APOSY A8R206_APOSY ------------------------------------------------------------ GNAS1_RAT GNAS1_RAT EDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVD Q9QYZ0_MOUSE Q9QYZ0_MOUSE ------------------------------------------------------------ A8R218_MUSPA A8R218_MUSPA ------------------------------------------------------------ A8R213_MUSCR A8R213_MUSCR ------------------------------------------------------------ A8R216_MUSSI A8R216_MUSSI ------------------------------------------------------------ A2A606_MOUSE A2A606_MOUSE ------------------------------------------------------FACA-- GNAS1_MOUSE GNAS1_MOUSE EDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVD A8R220_MUSSP A8R220_MUSSP ------------------------------------------------------------ A8R208_9MURI A8R208_9MURI ------------------------------------------------------------ A8R211_9MURI A8R211_9MURI ------------------------------------------------------------ GNAS1_HUMAN GNAS1_HUMAN EDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVD A5GFT9_PIG A5GFT9_PIG EDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVD A5GFU0_PIG A5GFU0_PIG EDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVD MATCH CONSENSUS ????????????????????????????????????????????????????????????

A8R206_APOSY A8R206_APOSY -------------------------- GNAS1_RAT GNAS1_RAT TENIRRVFNDCRDIIQRMHLRQYELL Q9QYZ0_MOUSE Q9QYZ0_MOUSE -------------------------- A8R218_MUSPA A8R218_MUSPA -------------------------- A8R213_MUSCR A8R213_MUSCR -------------------------- A8R216_MUSSI A8R216_MUSSI -------------------------- A2A606_MOUSE A2A606_MOUSE -------------------------- GNAS1_MOUSE GNAS1_MOUSE TENIRRVFNDCRDIIQRMHLRQYELL A8R220_MUSSP A8R220_MUSSP -------------------------- A8R208_9MURI A8R208_9MURI -------------------------- A8R211_9MURI A8R211_9MURI -------------------------- GNAS1_HUMAN GNAS1_HUMAN TENIRRVFNDCRDIIQRMHLRQYELL A5GFT9_PIG A5GFT9_PIG TENIRRVFNDCRDIIQRMHLRQYELL A5GFU0_PIG A5GFU0_PIG TENIRRVFNDCRDIIQRMHLRQYELL MATCH CONSENSUS ??????????????????????????


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