Alignment of the gene Family HBG080008 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
Q6DRM6_DANRE Q6DRM6_DANRE -----------PLDASDTCGIAASRSRREKKEKVGRKSALEQLKRAKKGEKVKYEVEEFT A6NMQ1_HUMAN A6NMQ1_HUMAN APVHGDDCEIGASALSDSGSFVSSRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDFT DPOLA_HUMAN DPOLA_HUMAN APVHGDD------SLSDSGSFVSSRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDFT A2A4H0_MOUSE A2A4H0_MOUSE APMHEEDCKLEASAVSDSGSFAASRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDLT DPOLA_MOUSE DPOLA_MOUSE APMHEEDCKLEASAVSDSGSFAASRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDLT DPOLA_RAT DPOLA_RAT APVHGDDCKLETSAVSDSGSFVASRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDLT Q59J88_IGUIG Q59J88_IGUIG ----------------------------------------------------------FT Q59J86_CHICK Q59J86_CHICK -------------------------------------------KKAKAGEKLKYEVEEFT Q59J87_CAICR Q59J87_CAICR ------------------------------------------------------------ Q59J89_TRASC Q59J89_TRASC ----------------------------------------------------------FT Q59J90_AMBME Q59J90_AMBME ------------------------------------------------------------ DPOLA_XENLA DPOLA_XENLA --------------MSDSGSFAASRSRREKTEKSGRKEALERLKRAKAGEKVKYEVEQVS B1WBE2_XENLA B1WBE2_XENLA --------------MSDSGSFAASRSRREKTEKSGRKEALERLKRAKAGEKVKYEVEQVS B7ZRF3_XENLA B7ZRF3_XENLA --------------MSDSGSFAASRSRREKTEKSGRKEALERLKRAKAGEKVKYEVEQVS MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q6DRM6_DANRE Q6DRM6_DANRE SIYDEVDEEQYSKIVRERQDDDWIIDDDGTGYVEDGREIFDEELDDDALGP--KSKQAAK A6NMQ1_HUMAN A6NMQ1_HUMAN GVYEEVDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDADEKGKDGKA DPOLA_HUMAN DPOLA_HUMAN GVYEEVDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDADEKGKDGKA A2A4H0_MOUSE A2A4H0_MOUSE SVYEEVDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDTCGKGSDGKA DPOLA_MOUSE DPOLA_MOUSE SVYEEVDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDTCGKGSDGKA DPOLA_RAT DPOLA_RAT SVYEEVDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDTCGEGSDGKA Q59J88_IGUIG Q59J88_IGUIG SVYDEIDEEQYSKIVRERQEDDWIVDDDGVGYVEDGREIFDEDLEDDVLDSNKKRKRDSA Q59J86_CHICK Q59J86_CHICK GVYDEIDEEQYSKIVRERQDDDWIVDDDGIGYVEDGREIFDEDLDDDALGSSKKGKTGKT Q59J87_CAICR Q59J87_CAICR -----------------------IIDDDGIGYVEDGREIFDEDLEDDALLPIKKGKGDK- Q59J89_TRASC Q59J89_TRASC SVYEEVDEAQYSKMVRERQDDDWIVDDDGIGYVEDGREIFDEDLEDDVLGSKKKGKGDKT Q59J90_AMBME Q59J90_AMBME -----------------------IVDDDGVGYVEDGREIFDDDLQDDVASNSSAAKGKKG DPOLA_XENLA DPOLA_XENLA SIYEEVDEAEYSKLVRDRQDDDWIVDDDGTGYVEDGREIFDDDLEDNALADSGKGAKGA- B1WBE2_XENLA B1WBE2_XENLA SIYEEVDEAEYSKLVRDRQDDDWIVDDDGTGYVEDGREIFDDDLEDNALADSGKGAKGA- B7ZRF3_XENLA B7ZRF3_XENLA SIYEEVDEAEYSKLVRDRQDDDWIVDDDGTGYVEDGREIFDDDLEDNALADSGKGAKGA- MATCH *:**** ***********::*:*:. CONSENSUS ??Y?E?DE??YSK?V??RQ?DDWIVDDDG?GYVEDGREIFD?DL?D??L????K??????

Q6DRM6_DANRE Q6DRM6_DANRE GGDSKKNVKKSSVSKPNSIKSMFMNSNVKKPAEKHVDLSQDDLLGDILQDLHSEKSVVLT A6NMQ1_HUMAN A6NMQ1_HUMAN RNKDKRNVKKLAVTKPNNIKSMFIACAGKKTADKAVDLSKDGLLGDILQDLNTE-TPQIT DPOLA_HUMAN DPOLA_HUMAN RNKDKRNVKKLAVTKPNNIKSMFIACAGKKTADKAVDLSKDGLLGDILQDLNTE-TPQIT A2A4H0_MOUSE A2A4H0_MOUSE HRKDRKDVKKPSVTKPNNIKAMFIASAGKKTTDKAVDLSKDDLLGDILQDLNTE-TAQIT DPOLA_MOUSE DPOLA_MOUSE HRKDRKDVKKPSVTKPNNIKAMFIASAGKKTTDKAVDLSKDDLLGDILQDLNTE-TAQIT DPOLA_RAT DPOLA_RAT HRKDRKDVKKPSVTKPNNIKAMFIASAGKKTTDKTVDLSKDDLLGDILQDLNTE-TPQIA Q59J88_IGUIG Q59J88_IGUIG STKEKKNVKKTLVSKPNTIKSMFMANTGKKNTDKTVDLSKDDLLGDILQDLNAE-SVHIA Q59J86_CHICK Q59J86_CHICK STIGKKNVKKSVVAKPNTIKSMFIASAGKKNTDKTVDLSKDDLLGDILQDLNAE-TVQLS Q59J87_CAICR Q59J87_CAICR -TNDKKNVKKSVVSKPNTIKSMFIASAGKKNTDKAVDLSKDDLLGDILQDLNAE----VT Q59J89_TRASC Q59J89_TRASC STNDKKNVKKSVVSKPNTIKSMFMASAGKKNTDKTVDLSKDDLLGDILQDLNAE-TIQIT Q59J90_AMBME Q59J90_AMBME NAQEKGNLKKPVVSKPNSIKTMFMASAGKKTADKTVDLSKDDLLGDILQDINAA-APIIS DPOLA_XENLA DPOLA_XENLA -PKDKTNVKKSSVSKPNNIKSMFMASAVKKTTDKAVDLSKDDLLGDLLQDLKSQ-AVPIT B1WBE2_XENLA B1WBE2_XENLA -PKDKTNVKKSSVSKPNNIKSMFMASAVKKTTDKAVDLSKDDLLGDLLQDLKSQ-AVPIT B7ZRF3_XENLA B7ZRF3_XENLA -PKDKTNVKKSSVSKPNNIKSMFMASAVKKTTDKAVDLSKDDLLGDLLQDLKSQ-AVPIT MATCH : ::** *:***.**:**: ** ::* ****:*.****:***::: :: CONSENSUS ???????VKK??V?KPN?IK?MF?A?A?KK??DK?VDLSKDDLLGD?LQDL?????????

Q6DRM6_DANRE Q6DRM6_DANRE PPPIITLKKKKTLGSPMNPFSVKPQM--P--KVKIPIPPADPSPR-----SAASVEPSKA A6NMQ1_HUMAN A6NMQ1_HUMAN PPPVMILKKKRSIGASPNPFSVHTATAVPSGKIASPVSRKEP--------PLTPVPLKRA DPOLA_HUMAN DPOLA_HUMAN PPPVMILKKKRSIGASPNPFSVHTATAVPSGKIASPVSRKEP--------PLTPVPLKRA A2A4H0_MOUSE A2A4H0_MOUSE PPPVLIPKKKRSTGALLNPFSVHTPKAIPSGKPASPVLRNEP--------LLTPIPLKRA DPOLA_MOUSE DPOLA_MOUSE PPPVLIPKKKRSTGALLNPFSVHTPKAIPSGKPASPVLRNEP--------LLTPIPLKRA DPOLA_RAT DPOLA_RAT PPPVLIPKKKRSTGASPNPFSVHTATAVPSGKIASPVSRKEP--------PLTPVPLKRA Q59J88_IGUIG Q59J88_IGUIG PPPVPVLKKKRIFGTPLNPFSLQSQAATS--KRFSSVVQKTVTSDKKETFTVNSSHSKHA Q59J86_CHICK Q59J86_CHICK PPPILVLKRKRSAGMPLNPFSVQRQS--P--KVITPVSKKAPVQLRKEARPPASFHPKHP Q59J87_CAICR Q59J87_CAICR PPPVVMMKKKRQAGTSLNPFSVQSQV--P--KVMAPVMQKASTPVRKEAVSLTTSCPKQV Q59J89_TRASC Q59J89_TRASC PPPVVKLRKKRPVGASLNPFSVQSPA--H--MVVTPIVRKAPTTVKKEVISPTTADPKHT Q59J90_AMBME Q59J90_AMBME LPPVVALKKKRLAGVARNPFSVQAPSLKV--TVPRPAVRTTPTLVTKP--SPSIVPGSHT DPOLA_XENLA DPOLA_XENLA PPPVITLKKKKLAGSPLNPFSVPPTA--P--KVLPTSVKRLPAVTK----PGHPAAQSKA B1WBE2_XENLA B1WBE2_XENLA PPPVITLKKKKLAGSPLNPFSVPPTA--P--KVLPTSVKRLPAVTK----PGHPAAQSKA B7ZRF3_XENLA B7ZRF3_XENLA PPPVITLKKKKLAGSPLNPFSVPPTA--P--KVLPASVKRLPAVTK----PGHPAAQSKA MATCH **: ::*: * ****: . .: CONSENSUS PPPV???KKK???G???NPFSV?????????K?????????P??????????????????

Q6DRM6_DANRE Q6DRM6_DANRE TAA--------------------------QIKKPKIEEPEEE----AIEFDEMDFDEPME A6NMQ1_HUMAN A6NMQ1_HUMAN EFAGDD---------------------------VQVESTEEEQESGAMEFEDGDFDEPME DPOLA_HUMAN DPOLA_HUMAN EFAGDD---------------------------VQVESTEEEQESGAMEFEDGDFDEPME A2A4H0_MOUSE A2A4H0_MOUSE ELAGEL---------------------------AQPECPEDEQELGVMEFEDGDFDESMD DPOLA_MOUSE DPOLA_MOUSE ELAGEL---------------------------AQPECPEDEQELGVMEFEDGDFDESMD DPOLA_RAT DPOLA_RAT EFAGDL---------------------------AQPECPEDEQESGVIEFEDGDFDEPMD Q59J88_IGUIG Q59J88_IGUIG VFPATSEAVKEKSLTPENEADPAE---NGVLLKMKQEDITKEDEQAMMDFDDGDFDVSME Q59J86_CHICK Q59J86_CHICK NYTAKSVTASEENEDTKYVQKATE---NGRVVKTKEEKAIEDDDQGMMDFDDEDFDEPME Q59J87_CAICR Q59J87_CAICR NFAAKTVANSKKNGTADCTVKAEEKALEGRLLKVKEEKVAEEEHQGMMDFDDGDFDEPME Q59J89_TRASC Q59J89_TRASC TYAAKPVAVHKENG-AEYTIKTAE---NEELVKAKPEKAIQENDQGMMDFEDGDFDEPME Q59J90_AMBME Q59J90_AMBME PASSKSFTVKQETIAPINAE-------NGRTVHVKVEEDTAEDDQGMMDFDYLNFDEPME DPOLA_XENLA DPOLA_XENLA SVPRQIKKEPKAELISS------------AVGPLKVEAQVKEEDSGMVEFDDGDFDEPME B1WBE2_XENLA B1WBE2_XENLA SVPRQIKKEPKAELISS------------AVGPLKVEAQVKEEDSGMVEFDDGDFDEPME B7ZRF3_XENLA B7ZRF3_XENLA SVPRQIKKEPKAELISS------------AVGPLKVEAQVKEEDSGMVEFDDGDFDEPME MATCH . : * : ::*: :** .*: CONSENSUS ????????????????????????????????????E????E???G???F?D?DFDE?M?

Q6DRM6_DANRE Q6DRM6_DANRE AENLE-EEPVKEKA-EPETKPIVKVEPKTEPQDK---MLISGLVGGMGWEKMEEGKPIET A6NMQ1_HUMAN A6NMQ1_HUMAN VEEVD-LEPMAAKAWDKESEPAEEVKQEADSGKGTVSYLGSFLPDVSCWDIDQEGDSSFS DPOLA_HUMAN DPOLA_HUMAN VEEVD-LEPMAAKAWDKESEPAEEVKQEADSGKGTVSYLGSFLPDVSCWDIDQEGDSSFS A2A4H0_MOUSE A2A4H0_MOUSE TEKVD-EKPVTAKTWDQETEPVERVEHEADPERGTTSYLENFLPDVSCWDIDQDDES--I DPOLA_MOUSE DPOLA_MOUSE TEKVD-EKPVTAKTWDQETEPVERVEHEADPERGTTSYLENFLPDVSCWDIDQDDES--I DPOLA_RAT DPOLA_RAT TEEVDEEEPVTAKIWDQESEPVEGVKHEADPETGTTSFLDSFLPDVSCWDIDQKDENSFL Q59J88_IGUIG Q59J88_IGUIG ------EDRTVVEAVTSVKEEVKLEDRQEDFEKTGSHFLNSSLPEIFCWDKIDEDEIGHL Q59J86_CHICK Q59J86_CHICK AELMG-AVPETAETLKRDKEVEKKEMEQLESKKKEASALSHSLPDISCWDKVEEDEADLV Q59J87_CAICR Q59J87_CAICR AGDMD-TVPETVRALKRDQEVEKKEAQQGNSVKEEPVG-HSSLPDISCWDRMGEEEVDLV Q59J89_TRASC Q59J89_TRASC AD-----IPETAGALKKEQKLEKKETQQVDSVKEDASFLSSFLPDMSCWTRMDKDETDLV Q59J90_AMBME Q59J90_AMBME AEDLNLLHSQTNIAKKEEEHKSEERAKELKPVKEEMCSQTIQLPEVSCWGKTDQEDSEVV DPOLA_XENLA DPOLA_XENLA -EDVE-ITPVDSSTIKTQAQSIKCVKEE-NIKEEKSSFITSATLNESCWDQIDEAEP--M B1WBE2_XENLA B1WBE2_XENLA -EDVE-ITPVDSSTIKTQAQSIKCVKEE-NIKEEKSSFITSATLNESCWDQIDEAEP--M B7ZRF3_XENLA B7ZRF3_XENLA -EDVE-ITPVDSSTIKTQAQSIKCVKEE-NIKEEKSSFITSATLNESCWDQIDEAEP--M MATCH . : . * . . CONSENSUS ????????P?????????????????????????????????????SCW???????????

Q6DRM6_DANRE Q6DRM6_DANRE PVEVQVDSSQLPLVEGPDGDMVFRFYWLDAFEDQYNQPGVVFLFGKVWIESAEAHVSCCV A6NMQ1_HUMAN A6NMQ1_HUMAN VQEVQVDSSHLPLVKGADEEQVFHFYWLDAYEDQYNQPGVVFLFGKVWIESAETHVSCCV DPOLA_HUMAN DPOLA_HUMAN VQEVQVDSSHLPLVKGADEEQVFHFYWLDAYEDQYNQPGVVFLFGKVWIESAETHVSCCV A2A4H0_MOUSE A2A4H0_MOUSE PQEVQVDSSNLPLVKGADDEQVFQFYWLDAYEDPYNQPGVVFLFGKVWIESVKTHVSCCV DPOLA_MOUSE DPOLA_MOUSE PQEVQVDSSNLPLVKGADDEQVFQFYWLDAYEDPYNQPGVVFLFGKVWIESVKTHVSCCV DPOLA_RAT DPOLA_RAT LQEVQVDSNHLPLVKGADDEQVFQFYWLDAYEDPYNQPGVVFLFGKVWVESAKTHVSCCV Q59J88_IGUIG Q59J88_IGUIG ASEIQVDSSQLPLITGADGQQIFRFYWLDAYEDQYNQPGVVFLFGKVWIESAKSYVSCCV Q59J86_CHICK Q59J86_CHICK ATDVQLDPNLLPLVNGENDDQVLRFYWLDAYEDQYSQPGVVFLFGKVWIESANTYVSCCV Q59J87_CAICR Q59J87_CAICR ASEVQVDPNVFPLVNGEDGDQVFRFYWLDAYEDQYNQPGVVFLFGKVWIESAKAYVSCCV Q59J89_TRASC Q59J89_TRASC ASEVQVDPSCLPLVNGEDGDQVFRFYWLDAYEDQYSQPGVVFLFGKVWIESAETYVSCCV Q59J90_AMBME Q59J90_AMBME VTDVQVDSSSLPLVIGTDGDQVFRFYWLDAYEDQYNQPGVVYLFGKVWIESAEAHVSCCL DPOLA_XENLA DPOLA_XENLA TTEIQVDSSHLPLVTGADGSQVFRFYWLDAYEDQYSQPGVVYLFGKVWIESADAYVSCCV B1WBE2_XENLA B1WBE2_XENLA TTEIQVDSSHLPLVTGADGSQVFRFYWLDAYEDQYSQPGVVYLFGKVWIESADAYVSCCV B7ZRF3_XENLA B7ZRF3_XENLA TTEIQVDSSHLPLVTGADGSQVFRFYWLDAYEDQYSQPGVVYLFGKVWIESADAYVSCCV MATCH ::*:*.. :**: * : . :::******:** *.*****:******:**..::****: CONSENSUS ??E?QVD???LPLV?G?D??QVF?FYWLDAYED?Y?QPGVV?LFGKVWIESA???VSCCV

Q6DRM6_DANRE Q6DRM6_DANRE AVKNIERTMYLLPREHKVNLATG-EKGVAVGMMDVYKEFNE-ISEKFKIMKFKSKPVTKN A6NMQ1_HUMAN A6NMQ1_HUMAN MVKNIERTLYFLPREMKIDLNTGKETGTPISMKDVYEEFDEKIATKYKIMKFKSKPVEKN DPOLA_HUMAN DPOLA_HUMAN MVKNIERTLYFLPREMKIDLNTGKETGTPISMKDVYEEFDEKIATKYKIMKFKSKPVEKN A2A4H0_MOUSE A2A4H0_MOUSE MVKNIERTLYFLPREMKFDLNTGKETAIPVTMKDVYEEFDSKISAKYKIMKFKSKIVEKN DPOLA_MOUSE DPOLA_MOUSE MVKNIERTLYFLPREMKFDLNTGKETAIPVTMKDVYEEFDSKISAKYKIMKFKSKIVEKN DPOLA_RAT DPOLA_RAT MVKNIERTLYFLPREMKIDLNTGKETATPITMKDVYEEFDSKISAKYKIMKFKSKIVEKN Q59J88_IGUIG Q59J88_IGUIG TVKNIERTIYLLPRESRIDKCSGKETENPVTMMDVYQEFNDHVAEKFKIMKYKSKKVEKN Q59J86_CHICK Q59J86_CHICK TVKNIERTVYLLPRETEMDLSSGKETETPVTIMNVFKEFNDCISPKYKIMKFKSKKVEKY Q59J87_CAICR Q59J87_CAICR TVKNIERTVYLLPRKMEVNLSSGQETENPVTIMSVYKEFNDQISVKYKIMKFKSKKVEKH Q59J89_TRASC Q59J89_TRASC TVKNIERIIYLLPREMQMDLTSGKETENPVTMMNIYQEFNDQIAVKYKIMKFRSKKVEKN Q59J90_AMBME Q59J90_AMBME TVKNIERTVYLLPRETQVDLSSGKETGTPVSMMNVYQEFNERIAEKFKLMKFKSKKIEKN DPOLA_XENLA DPOLA_XENLA SVKNIERTVYLLPRENRVQLSTGKDTGAPVSMMHVYQEFNEAVAEKYKIMKFKSKKVDKD B1WBE2_XENLA B1WBE2_XENLA SVKNIERTVYLLPRENRVQLSTGKDTGVPVSMMHVYQEFNEAVAEKYKIMKFKSKKVDKD B7ZRF3_XENLA B7ZRF3_XENLA SVKNIERTVYLLPRENRVQLSTGKDTGVPVSMMHVYQEFNEAVAEKYKIMKFKSKKVDKD MATCH ****** :*:***: ..: :* :. .: : :::**:. :: *:*:**::** : * CONSENSUS ?VKNIERT?Y?LPRE????L??GK?T??P??M??VY?EF??????K?KIMKFKSK?V?K?

Q6DRM6_DANRE Q6DRM6_DANRE YAFEIPDIPSQSEYLEVKYSAEIPSLPSDLKGTTFSHVFGTNTSSLEHFLLNRKIRGPCW A6NMQ1_HUMAN A6NMQ1_HUMAN YAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETFSHVFGTNTSSLELFLMNRKIKGPCW DPOLA_HUMAN DPOLA_HUMAN YAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETFSHVFGTNTSSLELFLMNRKIKGPCW A2A4H0_MOUSE A2A4H0_MOUSE YAFEIPDVPEKSEYLEVRYSAEVPQLPQNLKGETFSHVFGTNTSSLELFLMNRKIKGPCW DPOLA_MOUSE DPOLA_MOUSE YAFEIPDVPEKSEYLEVRYSAEVPQLPQNLKGETFSHVFGTNTSSLELFLMNRKIKGPCW DPOLA_RAT DPOLA_RAT YAFEIPDVPEKSEYLEVRYSAEVPQLPQNLKGETFSHVFGTNTSSLELFLMNRKIKGPCW Q59J88_IGUIG Q59J88_IGUIG YAFEIPDVPAKSDYLEVRYSAEYSRLPQDLKGETFSHVFGTNTSSLELLLMNRKIKGPGW Q59J86_CHICK Q59J86_CHICK YAFEIPDVPAKSEYLEVKYSAEYPRLPQDLKGETFSHVFGTNTSSLELLLMSRKIKGPCW Q59J87_CAICR Q59J87_CAICR YAFEIPDVPAKSDYLEVRYSAEFSRLPQDLKGETFSHVFGTNSSSLELLLMSRKIKGPCW Q59J89_TRASC Q59J89_TRASC YAFEIPDVPAKSDYLEVRYSAEFPRLPQDLKGETFSHVFGTNTSSLELLLMSRKIKGPSW Q59J90_AMBME Q59J90_AMBME YAFEIPDVPANSEYLEVRYSAELPPLPKDLKGETFSHVFGTNTSSLELFLLSRKIKGPSW DPOLA_XENLA DPOLA_XENLA YAFEIPDVPASSEYLEVRYSADSPQLPQDLKGETFSHVFGTNTSSLELFLLSRKIKGPSW B1WBE2_XENLA B1WBE2_XENLA YAFEIPDVPASSEYLEVRYSADSPQLPQDLKGETFSHVFGTNTSSLELFLLSRKIKGPSW B7ZRF3_XENLA B7ZRF3_XENLA YAFEIPDVPASSEYLEVRYSADSPQLPQDLKGETFSHVFGTNTSSLELFLLSRKIKGPSW MATCH *******:* .*:****:***: . **.:*** *********:**** :*:.***:** * CONSENSUS YAFEIPDVP??S?YLEV?YSA??P?LPQ?LKGETFSHVFGTNTSSLEL?L??RKIKGP?W

Q6DRM6_DANRE Q6DRM6_DANRE LDVTTPQLSNQPISWCKVEAVAQKSDLISVVKD-LSPPPLVVMSISLKTVQNPKTHQNEI A6NMQ1_HUMAN A6NMQ1_HUMAN LEVKSPQLLNQPVSWCKVEAMALKPDLVNVIKD-VSPPPLVVMAFSMKTMQNAKNHQNEI DPOLA_HUMAN DPOLA_HUMAN LEVKSPQLLNQPVSWCKVEAMALKPDLVNVIKD-VSPPPLVVMAFSMKTMQNAKNHQNEI A2A4H0_MOUSE A2A4H0_MOUSE LEVKNPQLLNQPISWCKFEVMALKPDLVNVIKD-VSPPPLVVMSFSMKTMQNVQNHQHEI DPOLA_MOUSE DPOLA_MOUSE LEVKNPQLLNQPISWCKFEVMALKPDLVNVIKD-VSPPPLVVMSFSMKTMQNVQNHQHEI DPOLA_RAT DPOLA_RAT LEVKNPQLLNQPISWCKFEAMALKPDLVNVIKD-VSPPPLVVMSFSMKTMQNVQNHQHEI Q59J88_IGUIG Q59J88_IGUIG LEIKNPQLSSQAVSWCKVELVALKPAFVNVVKD-LPPPPLVIMSLSMKTVQNTKTHQNEI Q59J86_CHICK Q59J86_CHICK LEIKNPQPSNQSVSWCKVEAVAMKPGLVNVVKDLLPPPPLVVMSFSMKTIQNPKTHQNEI Q59J87_CAICR Q59J87_CAICR LEIKNPQPSSQSVSWCKMEAVALKPDLVNVIKD-LPPPPLVVISLSIRTIPNPKTHQNEV Q59J89_TRASC Q59J89_TRASC LEIKNPQPLSHPVSWCKVEATALKPDLVNIVKD-LPPPPLVIMSLSMRTIQNVKTHQHEV Q59J90_AMBME Q59J90_AMBME LEIKTPQLSFQPVSWCKVEAVALKPDLVSVVKD-LPPPPLVVMALSMKTVQNAKTHQNEI DPOLA_XENLA DPOLA_XENLA LEIKSPQLSSQPMSWCKVEAVVTRPDQVSVVKD-LAPPPVVVLSLSMKTVQNAKTHQNEI B1WBE2_XENLA B1WBE2_XENLA LEIKSPQLSSQPMSWCKVEAVVTRPDQVSVVKD-LAPPPVVVLSLSMKTVQNAKTHQNEI B7ZRF3_XENLA B7ZRF3_XENLA LEIKSPQLSSQPMSWCKVEAVVTRPDQVSVVKD-LAPPPVVVLSLSMKTVQNAKTHQNEI MATCH *::..** :.:****.* . :. :.::** :.***:*::::*::*: * :.**:*: CONSENSUS LE?K?PQ???Q??SWCK?E?????PD?V?V?KD???PPP?VV???SMKT?QN???HQ?EI

Q6DRM6_DANRE Q6DRM6_DANRE VSIAALVHHTFPLDKAPPRPPFQTHFCESDTP----IKNNFQIASAGSSLKIRTLFYERA A6NMQ1_HUMAN A6NMQ1_HUMAN IAMAALVHHSFALDKAAPKPPFQSHFCVVSKPKDCIFPYAFKEVIEKKNVKVEVAATERT DPOLA_HUMAN DPOLA_HUMAN IAMAALVHHSFALDKAAPKPPFQSHFCVVSKPKDCIFPYAFKEVIEKKNVKVEVAATERT A2A4H0_MOUSE A2A4H0_MOUSE IAMAALVHHSFALDKAPPEPPFQTHFCVVSKPKDCIFPCDFKEVISKKNMKVEIAATERT DPOLA_MOUSE DPOLA_MOUSE IAMAALVHHSFALDKAPPEPPFQTHFCVVSKPKDCIFPCDFKEVISKKNMKVEIAATERT DPOLA_RAT DPOLA_RAT IAMAALVHHNFPLDKAPPKPPFQTHFCVVSKPKDCIFPCAFKEVIKKKNMEVEVAATERT Q59J88_IGUIG Q59J88_IGUIG MVITALVHHKFCLDKAPPVPPFQTHFCVISKPNDCIFPYDFKEIVKTKNAKIEIATTERT Q59J86_CHICK Q59J86_CHICK VAMAALIHQKFPLDKAPPQPPFQTHFCAVSKPNDCIFPYDFKEEIKKKNAKIEIAATERT Q59J87_CAICR Q59J87_CAICR MAIAALVHQNFCLDKAPPQPPFQTHFCVISKPNDCIFPYDFKDVIKTKNAKIEIAATERT Q59J89_TRASC Q59J89_TRASC MAVAALVHQRFCLDKAPPQPPFQTHFCVISKPNDCIFPYDFKEIIKSKNSNVEIAATERT Q59J90_AMBME Q59J90_AMBME VAISVLAHHKFPLDKAPPQPPFQTHFCVVCKPSDCIFPYDYKEAIKQKNANIEVALTERT DPOLA_XENLA DPOLA_XENLA VAIAALVHHTFPLDKAPPQPPFQTHFCVLSKLNDCIFPYDYNEAVKQKNANIEIALTERT B1WBE2_XENLA B1WBE2_XENLA VAIAALVHHTFPLDKAPPQPPFQTHFCVLSKLNDCIFPYDYNEAVKQKNANIEIALTERT B7ZRF3_XENLA B7ZRF3_XENLA VAIAALVHHTFPLDKAPPQPPFQTHFCVLSKLNDCIFPYDYNEAVKQKNANIEIALTERT MATCH : ::.* *: * ****.* ****:*** . : :: .. ::. **: CONSENSUS ?A?AALVH??F?LDKAPP?PPFQTHFCV?SK??DCIFP????E????KN???E?A?TERT

Q6DRM6_DANRE Q6DRM6_DANRE LLGFFPFKMHKIDPDVLLGHDIFGFDLEVLLQRINVCKVPHWSKIGRLRRANMPKLGGRS A6NMQ1_HUMAN A6NMQ1_HUMAN LLGFFLAKVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWSKIGRLKRSNMPKLGGRS DPOLA_HUMAN DPOLA_HUMAN LLGFFLAKVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWSKIGRLKRSNMPKLGGRS A2A4H0_MOUSE A2A4H0_MOUSE LIGFFLAKVHKIDPDILVGHNICSFELEVLLQRINECKVPYWSKIGRLRRSNMPKLGSRS DPOLA_MOUSE DPOLA_MOUSE LIGFFLAKVHKIDPDILVGHNICSFELEVLLQRINECKVPYWSKIGRLRRSNMPKLGSRS DPOLA_RAT DPOLA_RAT LLGFFLAKVHKLDPDILVGHNICGFELEVLLQRINECKVPFWSKIGRLRRSNMPKLGSRS Q59J88_IGUIG Q59J88_IGUIG LLGFFLAKVHKIDPDVIVGHNIYGFDLELLLQRINFCKVPHWSKIGRLRRSNMPKLGGRS Q59J86_CHICK Q59J86_CHICK LLGFFLAKIHKIDPDVVVGHNIYGFDLEVLLQRINVCKVPHWSKIGRLRRSNMPKLGGRG Q59J87_CAICR Q59J87_CAICR LLGFFLAKIHKIDPDVVVGHNIYGFDLEVLLQRINACKVPHWSKIGRLRRSNMPKLGGRG Q59J89_TRASC Q59J89_TRASC LLGFFLAKVHKIDPDIIVGHNIYGFDLEVLLQRINVSKVPHWSKIGRLRRSIMPKLGGRG Q59J90_AMBME Q59J90_AMBME LLGFLLAKIHKIDPDVIVGHDIYGFDLEVLLQRINVCKVPHWSKIGRLRRSIMPKLGGRS DPOLA_XENLA DPOLA_XENLA LLGFFLAKIHKIDPDVIVGHDIYGFDLEVLLQRINSCKVPFWSKIGRLRRSVMPKLGGRS B1WBE2_XENLA B1WBE2_XENLA LLGFFLAKIHKIDPDVIVGHDIYGFDLEVLLQRINSCKVPFWSKIGRLRRSVMPKLGGRS B7ZRF3_XENLA B7ZRF3_XENLA LLGFFLAKIHKIDPDVIVGHDIYGFDLEVLLQRINSCKVPFWSKIGRLRRSVMPKLGGRS MATCH *:**: *:**:***:::**:* .*:**:****** .*.*.*******:*: *****.*. CONSENSUS LLGFFLAK?HKIDPD??VGH?I?GF?LEVLLQRIN?CKVP?WSKIGRLRRS?MPKLG?R?

Q6DRM6_DANRE Q6DRM6_DANRE GFAEKSATCGRLVCDIEISAKELIRCKSYNLTELVSQILKAERPVVPPENISTFLQVDST A6NMQ1_HUMAN A6NMQ1_HUMAN GFGERNATCGRMICDVEISAKELIRCKSYHLSELVQQILKTERVVIPMENIQNMYS-ESS DPOLA_HUMAN DPOLA_HUMAN GFGERNATCGRMICDVEISAKELIRCKSYHLSELVQQILKTERVVIPMENIQNMYS-ESS A2A4H0_MOUSE A2A4H0_MOUSE GFGERNATCGRMICDVEISAKELIHCKSYHLSELVQQILKTERIVIPTENIRNMYS-ESS DPOLA_MOUSE DPOLA_MOUSE GFGERNATCGRMICDVEISAKELIHCKSYHLSELVQQILKTERIVIPTENIRNMYS-ESS DPOLA_RAT DPOLA_RAT GFGERNATCGRMICDVEISVKELIHCKSYHLSELVQQILKTERIVIPTENIRNMYS-EPS Q59J88_IGUIG Q59J88_IGUIG GFAEKNATCGRMICDVEISAKELIRCKSYHLTELVNQILKVERITVPPEEIRNMYS-DPR Q59J86_CHICK Q59J86_CHICK GFGERNAACGRMICDVEISAKELIRCKSYHLSELVHQILKTERVTILPEEIRNLYS-DSP Q59J87_CAICR Q59J87_CAICR GFAERNAACGRMICDVEISAKELIRCKSYHLSELVHQILKTERITIPPEEIRKMFS-NSS Q59J89_TRASC Q59J89_TRASC GFAERNAACGRMICDVEISAKELIRCKSYHLSELVHQILKTERITIPPEEIRNMYS-DSS Q59J90_AMBME Q59J90_AMBME GFAERNAACGRMICDVQISAKELIRCKSYHLSELVHQILKTERLIIPGENIRNYYS-DSP DPOLA_XENLA DPOLA_XENLA GFAERNAACGRIICDIEISAKELIRCKSYHLSELVHQILKAERVVIPPENIRNAYN-DSV B1WBE2_XENLA B1WBE2_XENLA GFAERNAACGRIICDIEISAKELIRCKSYHLSELVHQILKAERVVIPPENIRNAYN-DSV B7ZRF3_XENLA B7ZRF3_XENLA GFAERNAACGRIICDIEISAKELIRCKSYHLSELVHQILKAERVVIPPENIRNAYN-DSV MATCH **.*:.*:***::**::**.****:****:*:*** ****.** : *:* . . :. CONSENSUS GF?ERNA?CGR?ICD?EISAKELI?CKSYHLSELV?QILK?ER??IP?E?I?N?Y???S?

Q6DRM6_DANRE Q6DRM6_DANRE HLLYLLELTWMDAKLILQIMCELNVLPLALQITNIAGNVMSRTLMGGRSERNEYLLLHAF A6NMQ1_HUMAN A6NMQ1_HUMAN QLLYLLEHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNEFLLLHAF DPOLA_HUMAN DPOLA_HUMAN QLLYLLEHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNEFLLLHAF A2A4H0_MOUSE A2A4H0_MOUSE YLLYLLEHIWKDARFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNEFLLLHAF DPOLA_MOUSE DPOLA_MOUSE YLLYLLEHIWKDARFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNEFLLLHAF DPOLA_RAT DPOLA_RAT HLLYLLEHIWKDARFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNEFLLLHAF Q59J88_IGUIG Q59J88_IGUIG QLLYMVENTWTDAKYILQIMCDLNVLPLALQITNIAGNVMSRTLMGGRAERNEYLLLHAF Q59J86_CHICK Q59J86_CHICK HLLFMLENTWTDAKFILQIMCELNVLPLALQITNISGNVMSRTMMGGRSERNEFLLLHAF Q59J87_CAICR Q59J87_CAICR HLMCMLENSWTDAKFILQIMCELNVLPLALQITNISGNIMSRTMMGGRSERNEYLLLHAF Q59J89_TRASC Q59J89_TRASC HLLYMLENTWTDARFILQIMCELNVLPLALQITNISGNVMSRTMMGGRSERNEFLLLHAF Q59J90_AMBME Q59J90_AMBME QLLYMLEHTWLDTKFILQIMCELNVLPLALQITNIAGNVMSRTLMGGRSERNEYLLLHAF DPOLA_XENLA DPOLA_XENLA HLLYMLENTWIDAKFILQIMCELNVLPLALQITNIAGNVMSRTLMGGRSERNEYLLLHAF B1WBE2_XENLA B1WBE2_XENLA HLLYMLENTWIDAKFILQIMCELNVLPLALQITNIAGNVMSRTLMGGRSERNEYLLLHAF B7ZRF3_XENLA B7ZRF3_XENLA HLLYMLENTWIDAKFILQIMCELNVLPLALQITNIAGNVMSRTLMGGRSERNEYLLLHAF MATCH *: ::* * *:: ******:*************:**:****:****:****:****** CONSENSUS ?LLY?LE??W?DA?FILQIMCELNVLPLALQITNI?GN?MSRT?MGGRSERNE?LLLHAF

Q6DRM6_DANRE Q6DRM6_DANRE HERDFIVPDKQFFKKAQQDLGEDEEG-DSGKGKSNKTRKKAAYAGGLVLDPKVGFYDKFI A6NMQ1_HUMAN A6NMQ1_HUMAN YENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKAAYAGGLVLDPKVGFYDKFI DPOLA_HUMAN DPOLA_HUMAN YENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKAAYAGGLVLDPKVGFYDKFI A2A4H0_MOUSE A2A4H0_MOUSE YENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKATYAGGLVLDPKVGFYDKFI DPOLA_MOUSE DPOLA_MOUSE YENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKATYAGGLVLDPKVGFYDKFI DPOLA_RAT DPOLA_RAT YENNYIVPDKQIFRKPQQKPGDEDEEIDGDTNKYKKGRKKAAYAGGLVLDPKVGFYDKFI Q59J88_IGUIG Q59J88_IGUIG YEKNFIVPDKQLFKKTQKQL-EEDEDFEGDQNKSKTGRKKAAYSGGLVLEPKVGFYDKFI Q59J86_CHICK Q59J86_CHICK YEKDYIVPDKQVFKKPLQKLVDEDEDFE-DQNKSKIGKKKAAYAGGLVLDPKVGFYDKFI Q59J87_CAICR Q59J87_CAICR YERDYIVPDKQVFKKPQQKLVDEDEDFE-DQTKSKIGRKKAAYAGGLVLDPKVGFYDKFI Q59J89_TRASC Q59J89_TRASC YERDYIVPDKQVFKKPQQKLVDEDEGVE-DQNKSKIGRKKAAYAGGLVLDPKVGFYDTFI Q59J90_AMBME Q59J90_AMBME YENNFIVPDKPTFKKPLQNLVDEDEDIENDQGKQKKVRKKAAYAGGLVLDPKVGFYDKFI DPOLA_XENLA DPOLA_XENLA TENNFIVPDKPVFKKMQQTTVEDNDDMGTDQNKNK-SRKKAAYAGGLVLEPKVGFYDKFI B1WBE2_XENLA B1WBE2_XENLA TENNFIVPDKPVFKKMQQTTVEDNDDMGTDQNKNK-SRKKAAYAGGLVLEPKVGFYDKFI B7ZRF3_XENLA B7ZRF3_XENLA TENNFIVPDKPVFKKMQQTTVEDNDDMGTDQNKNK-SRKKAAYAGGLVLEPKVGFYDKFI MATCH *.::***** *:* : :::: . * : :***:*:*****:*******.** CONSENSUS ?E???IVPDK??F?K?QQ???????????D??K?K??RKKAAYAGGLVL?PKVGFYDKFI

Q6DRM6_DANRE Q6DRM6_DANRE LLLDFNSLYPSIIQEFNICFTTVERGATNTRKKTE-EDEDEIPELPDQSLEMGILPKEIR A6NMQ1_HUMAN A6NMQ1_HUMAN LLLDFNSLYPSIIQEFNICFTTVQRVASEAQKVTEDGEQEQIPELPDPSLEMGILPREIR DPOLA_HUMAN DPOLA_HUMAN LLLDFNSLYPSIIQEFNICFTTVQRVASEAQKVTEDGEQEQIPELPDPSLEMGILPREIR A2A4H0_MOUSE A2A4H0_MOUSE LLLDFNSLYPSIIQEFNICFTTVQRVTSEVQKATEDEEQEQIPELPDPNLEMGILPREIR DPOLA_MOUSE DPOLA_MOUSE LLLDFNSLYPSIIQEFNICFTTVQRVTSEVQKATEDEEQEQIPELPDPNLEMGILPREIR DPOLA_RAT DPOLA_RAT LLLDFNSLYPSIIQEFNICFTTVQRVASETLKATEDEEQEQIPELPDPNLDMGILPREIR Q59J88_IGUIG Q59J88_IGUIG LLLDFNSLYPSIIQEFNICFTTVHRVSSSLHKNTEDGEEEEIPELPDSSLDMGILPKEIR Q59J86_CHICK Q59J86_CHICK LLLDFNSLYPSIIQEFNICFTTVQRLSSEAQKRAEVEEEEEIPELPDPSLEMGILPKEIR Q59J87_CAICR Q59J87_CAICR LLLDFNSLYPSIIQEFNICFTTVQRVSSDVQKRTEEGEEEEIPELPDSSLEMGILPKEIR Q59J89_TRASC Q59J89_TRASC LLLDFNSLYPSIIQEFNICFTTVQRESSDAQKRAEDGVQEEIPELPDPSLEMGILPKEIR Q59J90_AMBME Q59J90_AMBME LLLDFNSLYPSIIQEFNICFTTVQRLDSNAQKMPEGEEQDDIPQLPDPDLELGILPREIR DPOLA_XENLA DPOLA_XENLA LLLDFNSLYPSIIQEYNICFTTVHREAPSTQK---GEDQDEIPELPHSDLEMGILPREIR B1WBE2_XENLA B1WBE2_XENLA LLLDFNSLYPSIIQEYNICFTTVHREAPSTQK---GEDQDEIPELPHSDLEMGILPREIR B7ZRF3_XENLA B7ZRF3_XENLA LLLDFNSLYPSIIQEYNICFTTVHREAPSTQK---GEDQDEIPELPHSDLEMGILPREIR MATCH ***************:*******.* .. * :::**:**. .*::****:*** CONSENSUS LLLDFNSLYPSIIQE?NICFTTV?R??????K?????????IPELP???LEMGILP?EIR

Q6DRM6_DANRE Q6DRM6_DANRE KLVERRRQVKQLMKEPDLNPDLYLQYDIRQKALKLTANSMYGCLGFSFSRFYAKPLAALV A6NMQ1_HUMAN A6NMQ1_HUMAN KLVERRKQVKQLMKQQDLNPDLILQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALV DPOLA_HUMAN DPOLA_HUMAN KLVERRKQVKQLMKQQDLNPDLILQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALV A2A4H0_MOUSE A2A4H0_MOUSE KLVERRKQVKQLMKQQDLNPDLVLQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALV DPOLA_MOUSE DPOLA_MOUSE KLVERRKQVKQLMKQQDLNPDLVLQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALV DPOLA_RAT DPOLA_RAT KLVERRKQVKQLMKQQDLNPDLVLQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALV Q59J88_IGUIG Q59J88_IGUIG KLVERRRQVKQLMKQPDLNSDLYLQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALV Q59J86_CHICK Q59J86_CHICK KLVERRRQVKQLMKQPDLNPDLYLQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALV Q59J87_CAICR Q59J87_CAICR KLVERRRQVKQLMKQPHLNPDLYLQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALV Q59J89_TRASC Q59J89_TRASC KLVERRRQVKQLMKQPDLNPDLYLQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALV Q59J90_AMBME Q59J90_AMBME KLVERRRQVKQLMKQSDLNPDLYMQYDIRQKALKLTANSMYGCLGFSFSRFYAKPLAALV DPOLA_XENLA DPOLA_XENLA KLVERRRHVKQLMKQPDLNPDLYLQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALV B1WBE2_XENLA B1WBE2_XENLA KLVERRRHVKQLMKQPDLNPDLYLQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALV B7ZRF3_XENLA B7ZRF3_XENLA KLVERRRHVKQLMKQPDLNPDLYLQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALV MATCH ******::******: .**.** :***********************:************ CONSENSUS KLVERR??VKQLMKQ?DLNPDL?LQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALV

Q6DRM6_DANRE Q6DRM6_DANRE THKGREILMHTKEMVQRMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKLL A6NMQ1_HUMAN A6NMQ1_HUMAN TYKGREILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKLL DPOLA_HUMAN DPOLA_HUMAN TYKGREILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKLL A2A4H0_MOUSE A2A4H0_MOUSE TYKGREILMHTKDMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKLL DPOLA_MOUSE DPOLA_MOUSE TYKGREILMHTKDMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKLL DPOLA_RAT DPOLA_RAT TYKGREILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKNEVNKLYKLL Q59J88_IGUIG Q59J88_IGUIG TFKGREILMHTKEMVEKMNLEVIYGDTDSIMINTNITNLEEVFKLGNKIKSEVNKLYKLL Q59J86_CHICK Q59J86_CHICK THKGREILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLDEVFKLGNKIKSEVNKLYKLL Q59J87_CAICR Q59J87_CAICR THKGREILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVLKLGNKIKSEVNRLYKLL Q59J89_TRASC Q59J89_TRASC THKGREILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKIKSEVNKLYKLL Q59J90_AMBME Q59J90_AMBME THKGREILLHTRDMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKQL DPOLA_XENLA DPOLA_XENLA THQGREILLHTKEMVQKMNLEVIYGDTDSIMINTNCNNLEEVFKLGNRVKSEINKSYKLL B1WBE2_XENLA B1WBE2_XENLA THQGREILLHTKEMVQKMNLEVIYGDTDSIMINTNCNNLEEVFKLGNRVKSEINKSYKLL B7ZRF3_XENLA B7ZRF3_XENLA THQGREILLHTKEMVQKMNLEVIYGDTDSIMINTNCNNLEEVFKLGNRVKSEINKSYKLL MATCH *.:*****:**::**::****************** .**:**:****::*.*:*: ** * CONSENSUS T??GREIL?HTK?MVQKMNLEVIYGDTDSIMINTN??NLEEVFKLGN??KSE?NK?YKLL

Q6DRM6_DANRE Q6DRM6_DANRE EIDIDGVFKSLLLLKKKKYAALMVEPQGDGKYTTKQELKGLDIVRRDWCDLAKECGNYVI A6NMQ1_HUMAN A6NMQ1_HUMAN EIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIVRRDWCDLAKDTGNFVI DPOLA_HUMAN DPOLA_HUMAN EIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIVRRDWCDLAKDTGNFVI A2A4H0_MOUSE A2A4H0_MOUSE EIDIDAVFKSLLLLKKKKYAALVVEPTSDGNYITKQELKGLDIVRRDWCDLAKDTGNFVI DPOLA_MOUSE DPOLA_MOUSE EIDIDAVFKSLLLLKKKKYAALVVEPTSDGNYITKQELKGLDIVRRDWCDLAKDTGNFVI DPOLA_RAT DPOLA_RAT EIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYITKQELKGLDIVRRDWCDLAKDTGNFVI Q59J88_IGUIG Q59J88_IGUIG EIDIDGIFKSLLLLKKKKYAALVVEPTGDGKYITKQELKGLDIVRRDWCDLAKETGNYII Q59J86_CHICK Q59J86_CHICK EIDIDGVFKSLLLLKKKKYAALTVEPTGDGKYVTKQELKGLDIVRRDWCDLAKETGNYVI Q59J87_CAICR Q59J87_CAICR EIDIDGIFKSLLLLKKKKYAALTVEPTGDGNYVTKQELKGLDIVRRDWCDLAKESGNYVI Q59J89_TRASC Q59J89_TRASC EIDIDGVFKSLLLLKKKKYAALTVEPTGDGKYVTKQELKGLDIVRRDWCDLAKETGNYVI Q59J90_AMBME Q59J90_AMBME EIDIDGVFKSLLLLKKKKYAALTMEPAGDGKYVTKQELKGLDIVRRDWCDLAKETGNYII DPOLA_XENLA DPOLA_XENLA EIDIDGIFKSLLLLKKKKYAALTVEPTGDGKYVTKQELKGLDIVRRDWCELAKQAGNYVI B1WBE2_XENLA B1WBE2_XENLA EIDIDGIFKSLLLLKKKKYAALTVEPTGDGKYVTKQELKGLDIVRRDWCELAKQAGNYVI B7ZRF3_XENLA B7ZRF3_XENLA EIDIDGIFKSLLLLKKKKYAALTVEPTGDGKYVTKQELKGLDIVRRDWCELAKQAGNYVI MATCH *****.:*************** :** .**:* ****************:***: **::* CONSENSUS EIDIDG?FKSLLLLKKKKYAAL?VEPT?DG?Y?TKQELKGLDIVRRDWC?LAK??GN?VI

Q6DRM6_DANRE Q6DRM6_DANRE GQILSDQNRDTIIENIQKHLIEIGEKVANGNIPLNMFEIHKSLTKEPQDYPDKKSLPHVH A6NMQ1_HUMAN A6NMQ1_HUMAN GQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKDPQDYPDKKSLPHVH DPOLA_HUMAN DPOLA_HUMAN GQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKDPQDYPDKKSLPHVH A2A4H0_MOUSE A2A4H0_MOUSE GQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKDPQDYPDRKSLPHVH DPOLA_MOUSE DPOLA_MOUSE GQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKDPQDYPDRKSLPHVH DPOLA_RAT DPOLA_RAT GQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKDPQDYPDKKSLPHVH Q59J88_IGUIG Q59J88_IGUIG SQILSDQFRDVIVENIQRRLIQIGENVVNGSVPIKQFEINKALTKDPQDYPDKKSLPHVH Q59J86_CHICK Q59J86_CHICK GQILSDQPRDIIVENIQRRLIEIGENVINGQIPVNQFEINKALTKDPQDYPDKKSLPHVH Q59J87_CAICR Q59J87_CAICR GQILSDQTRDIIVENIQRRLIDIGENVTNGTVPISQFEINKALTKDPQDYPDKKSLPHVH Q59J89_TRASC Q59J89_TRASC GQILSDQSRDTIVENIQRRLIEIGENVINGRVPISQFEINKALTKDPQDYPDKKSLPHVH Q59J90_AMBME Q59J90_AMBME TQILSDQPRDTIVENIQKQLIEIGENVVNGSIPINQYEINKALTKDPQDYPDKKSLPHVH DPOLA_XENLA DPOLA_XENLA SQILSDQPRDSIVENIQKKLTEIGENVTNGTVPITQYEINKALTKDPQDYPDKKSLPHVH B1WBE2_XENLA B1WBE2_XENLA SQILSDQPRDSIVENIQKKLTEIGENVTNGTVPITQYEINKALTKDPQDYPDKKSLPHVH B7ZRF3_XENLA B7ZRF3_XENLA SQILSDQPRDSIVENIQKKLTEIGENVTNGTVPITQYEINKALTKDPQDYPDKKSLPHVH MATCH ****** ** *:****::* :***:* ** :*:. :**:*:***:******:******* CONSENSUS ?QILSDQ?RD?IVENIQ??L?EIGENV?NG??P??Q?EINKALTKDPQDYPDKKSLPHVH

Q6DRM6_DANRE Q6DRM6_DANRE VALWINSQGGKKVKAGDTVSYVICQDGSNLAASQRAYTLEQLQKQPGLNLDTQYYLSQQV A6NMQ1_HUMAN A6NMQ1_HUMAN VALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQKQDNLTIDTQYYLAQQI DPOLA_HUMAN DPOLA_HUMAN VALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQKQDNLTIDTQYYLAQQI A2A4H0_MOUSE A2A4H0_MOUSE VALWINSQGGRKVKAGDTVSYVICQDGSNLTATQRAYAPEQLQKLDNLAIDTQYYLAQQI DPOLA_MOUSE DPOLA_MOUSE VALWINSQGGRKVKAGDTVSYVICQDGSNLTATQRAYAPEQLQKLDNLAIDTQYYLAQQI DPOLA_RAT DPOLA_RAT VALWINSQGGRKVKAGDTVSYVICQDGSNLPATQRAYAPEQLQKQDNLAIDTQYYLAQQI Q59J88_IGUIG Q59J88_IGUIG VALWINSQEGRKLKAGDTVSYVICQDGSNLSASQRAYAPEQLKKQENLAIDTQYYLSQQI Q59J86_CHICK Q59J86_CHICK VAMWINSQGGRKVKAGDTVSYIICQDGSNLSASQRAYAPEQLQKQDNLTIDTQYYLSQQI Q59J87_CAICR Q59J87_CAICR VAMWINSQGGRKVKSGDTVSYVICQDGSNLSASQRAYAPEQLQKQENLTIDTQYYLSQQI Q59J89_TRASC Q59J89_TRASC VAMWINSQEGRKVKAGDTVSYVICQDGSNLSASQRAYAPEQLQKQENLTVDTQYYLSQQI Q59J90_AMBME Q59J90_AMBME VALWINSQGGRKMKAGDTVSYIICQDGSNLSASQRAYALEQLQKQDNLAIDTQYYLSQQV DPOLA_XENLA DPOLA_XENLA VALWINSQGGRKVKAGDTISYVICQDGSNLSASQRAYAQEQLQKQENLSIDTQYYLSQQV B1WBE2_XENLA B1WBE2_XENLA VALWINSQGGRKVKAGDTISYVICQDGSNLSASQRAYAQEQLQKQENLSIDTQYYLSQQV B7ZRF3_XENLA B7ZRF3_XENLA VALWINSQGGRKVKAGDTISYVICQDGSNLSASQRAYAQEQLQKQENLSIDTQYYLSQQV MATCH **:***** *:*:*:***:**:********.*:****: ***:* .* :******:**: CONSENSUS VA?WINSQGGRKVKAGDT?SYVICQDGSNL?A?QRAYA?EQLQKQ?NL?IDTQYYL?QQ?

Q6DRM6_DANRE Q6DRM6_DANRE HPVVGRICEPIEGIDAVLIATWLGLDPSHFRA-QQQQREDEADDFLGAPAQLTDEERYRD A6NMQ1_HUMAN A6NMQ1_HUMAN HPVVARICEPIDGIDAVLIATWLGLDPTQFRV-HHYHKDEENDALLGGPAQLTDEEKYRD DPOLA_HUMAN DPOLA_HUMAN HPVVARICEPIDGIDAVLIATWLGLDPTQFRV-HHYHKDEENDALLGGPAQLTDEEKYRD A2A4H0_MOUSE A2A4H0_MOUSE HPVVARICEPIDGIDAVLIALWLGLDSTQFRV-HQYHKDEENDALLGGPAQLTDEEKYKD DPOLA_MOUSE DPOLA_MOUSE HPVVARICEPIDGIDAVLIALWLGLDSTQFRV-HQYHKDEENDALLGGPAQLTDEEKYKD DPOLA_RAT DPOLA_RAT HPVVARICEPIDGIDAVLIALWLGLDSTQFRV-HQYHKDEENDALLGGPAQLTDEEKYKD Q59J88_IGUIG Q59J88_IGUIG HPVVARICEPIDGIDSVLIAAWLGLDPSQFKVYHHYHKDEENDDLLGGPVQLTDEEKYKD Q59J86_CHICK Q59J86_CHICK HPVVARICEPIEGIDSVLIATWLGLDPSQFRVHHHYHKDEENDALVGGPAQLTDEEKYRD Q59J87_CAICR Q59J87_CAICR HPVVARICEPIDGIDSVLIATWLGLDPSQFKVHHHYHKDEENDAFLGGLAQFTDEEKYRD Q59J89_TRASC Q59J89_TRASC HPVVARICEPIDGIDSVLIATWLGLDPSQFKIHHHYHKDEENDALLGGPAQLTDEEKYRD Q59J90_AMBME Q59J90_AMBME HPVVARICEPIDGIDSALIAAWLGLDPSQFRVQSHYQKDEENDAMLGGPSQITDEEKYKD DPOLA_XENLA DPOLA_XENLA HPVVARICEPIDGIDSALIAMWLGLDPSQFRAHRHYQQDEENDALLGGPSQLTDEEKYRD B1WBE2_XENLA B1WBE2_XENLA HPVVARICEPIDGIDSALIAMWLGLDPSQFRAHRHYQQDEENDALLGGPSQLTDEEKYRD B7ZRF3_XENLA B7ZRF3_XENLA HPVVARICEPIDGIDSALIAMWLGLDPSQFRAHRHYQQDEENDALLGGPSQLTDEEKYRD MATCH ****.******:***:.*** *****.::*: : ::::* * ::*. *:****:*:* CONSENSUS HPVVARICEPIDGID??LIA?WLGLD??QF?????Y??DEENDA?LGGP?QLTDEEKY?D

Q6DRM6_DANRE Q6DRM6_DANRE CERFTFTCPDCGTENIYDNVFEGTGSTLQLSLKSCCHVPCGGSPMDHQVQIGNKLQLDIR A6NMQ1_HUMAN A6NMQ1_HUMAN CERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKASPLTFTVQLSNKLIMDIR DPOLA_HUMAN DPOLA_HUMAN CERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKASPLTFTVQLSNKLIMDIR A2A4H0_MOUSE A2A4H0_MOUSE CEKFKCLCPSCGTENIYDNVFEGSGLDMEPSLYRCSNVDCKVSPLTFMVQLSNKLIMDIR DPOLA_MOUSE DPOLA_MOUSE CEKFKCLCPSCGTENIYDNVFEGSGLDMEPSLYRCSNVDCKVSPLTFMVQLSNKLIMDIR DPOLA_RAT DPOLA_RAT CEKFKCLCPSCGTENIYDNVFEGSGMDMEPSLNRCSNIDCKASPATFMVQLSNKLIMDIR Q59J88_IGUIG Q59J88_IGUIG CERFKFACPKCGTENIYDNVVNGSDMMIEASLLYCSKKECNESPWKYLMQINNRLILDIR Q59J86_CHICK Q59J86_CHICK CERFKFCCLKCGTENIYDNVFDCSGRFIEPSLQRCSKSECEEPPFNHVVQMNNKLLLDIR Q59J87_CAICR Q59J87_CAICR CERFKFPCPKCGTENIYDSVFDGSGQFLEPSLQQCSKKECNELPFCHVTQMNNKLLFDIR Q59J89_TRASC Q59J89_TRASC CERFKFSCPRCGTENIYDNVFDGSGKLMEPSLQQCSKKECDESPFNYTIQMNNKLLLDIR Q59J90_AMBME Q59J90_AMBME CERFKFTCPACGTEGIYDNAFDGSGALMEPILKRCCKPECDASPMHFVIQLQNKLHLDIR DPOLA_XENLA DPOLA_XENLA CERFKFFCPKCGTENIYDNVFDGSGLQIEPGLKRCSKPECDASPLDYVIQVHNKLLLDIR B1WBE2_XENLA B1WBE2_XENLA CERFKFFCPKCGTENIYDNVFDGSGLQIEPGLKRCSKPECDASPLDYVIQVHNKLLLDIR B7ZRF3_XENLA B7ZRF3_XENLA CERFKFFCPKCGTENIYDNVFDGSGLQIEPGLKRCSKPECDASPLDYVIQVHNKLLLDIR MATCH **:*. * ****.***...: :. :: * *.: * * . *: *:* :*** CONSENSUS CE?FK??CP?CGTENIYDNVF?GSG???EP?L??CS???C??SP?????Q??NKL??DIR

Q6DRM6_DANRE Q6DRM6_DANRE RHIRRYYSGWLLCEDQACRNRIRRLPIAFSRSGPICPACLRSTLKPEYSEKALYNQLSFY A6NMQ1_HUMAN A6NMQ1_HUMAN RFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQPEYSDKSLYTQLCFY DPOLA_HUMAN DPOLA_HUMAN RFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQPEYSDKSLYTQLCFY A2A4H0_MOUSE A2A4H0_MOUSE RCIKKYYDGWLICEEPTCCSRLRRLPLHFSRNGPLCPVCMKAVLRPEYSDKSLYTQLCFY DPOLA_MOUSE DPOLA_MOUSE RCIKKYYDGWLICEEPTCCSRLRRLPLHFSRNGPLCPVCMKAVLRPEYSDKSLYTQLCFY DPOLA_RAT DPOLA_RAT RCIKKYYDGWLICEEPTCRNRIRRLPLHFSRNGPLCPACMKAVLRPEYSDKSLYTQLCFY Q59J88_IGUIG Q59J88_IGUIG SYIKKYYTSWLRCEEPTCQYRTRRLPLRFSKNGPLCPVCKKAVVKREYSDKVLFTQLCFY Q59J86_CHICK Q59J86_CHICK RYLKKYYNGWLICEDPTCQNRTRRLPLSFSRSGPICQACRKAILRPEYSDKALYTQLCFY Q59J87_CAICR Q59J87_CAICR CYLKKYYNGWLICEDPACQNRTRRLPLSFSRNGPLCQACRKAVLRPEYSDKALYNQLCFY Q59J89_TRASC Q59J89_TRASC RYLKSYYNSWLICEEPTCQNRTRRLPLSFSQNGALCQACKKAILRPEYSDKALYTQLCFY Q59J90_AMBME Q59J90_AMBME RHIKKYYSAWFICEEPTCQNRTRRLPLNFSRNGPICQACMKATLRPEYPDKALYTQLCFY DPOLA_XENLA DPOLA_XENLA RYIKKYYSGWLVCEEKTCQNRTRRLPLSFSRNGPICQACSKATLRSEYPEKALYTQLCFY B1WBE2_XENLA B1WBE2_XENLA RYIKKYYSGWLVCEEKTCQNRTRRLPLSFSRNGPICQACSKATLRSEYPEKALYTQLCFY B7ZRF3_XENLA B7ZRF3_XENLA RYIKKYYSGWLVCEEKTCQNRTRRLPLSFSRNGPICQACSKATLRSEYPEKALYTQLCFY MATCH :: ** .*: **: :* * *:**: **:.*.:* .* :: :: **.:* *:.**.** CONSENSUS R??KKYY??WL?CE??TC??R?RRLPL?FSR?GP?C??C?KA?L??EY??K?LYTQLCFY

Q6DRM6_DANRE Q6DRM6_DANRE RYIFDWEYAINKVLTG-------------------------------------------- A6NMQ1_HUMAN A6NMQ1_HUMAN RYIFDAECALEKLTTDHEKDKLKKQ-FFTPKVLQDYRKLKNTAEQFLSRSGYSEVNLSKL DPOLA_HUMAN DPOLA_HUMAN RYIFDAECALEKLTTDHEKDKLKKQ-FFTPKVLQDYRKLKNTAEQFLSRSGYSEVNLSKL A2A4H0_MOUSE A2A4H0_MOUSE RYIFDADCALEKL-TEHEKDKLKKQ-FFPLRVLQDYRKVKNIAEQFLSWSGYSEVNLSKL DPOLA_MOUSE DPOLA_MOUSE RYIFDADCALEKL-TEHEKDKLKKQ-FFPLRVLQDYRKVKNIAEQFLSWSGYSEVNLSKL DPOLA_RAT DPOLA_RAT RYIFDADCALEKL-PEHEKDKLKKQ-FFTPRVLQDYRKVKNIAEHFLSWSG--------- Q59J88_IGUIG Q59J88_IGUIG RYIFDVDYAKQKL-TNQEKDRLKSQGFFDNKTMEMYKKLKNTVDQWLAMSSYSEVNLSKL Q59J86_CHICK Q59J86_CHICK RYIFDVEYAMDKVITEEDREFVRRK-PLRKEVSEAYRKLKSTVDKCLSLSSYSEVNLGKL Q59J87_CAICR Q59J87_CAICR RYIFDVEYAMDKVITEEEKVWAEKN-LALKKIKEVYKKLKNTVDTCLSMSSYSEVNLGKL Q59J89_TRASC Q59J89_TRASC RYIFDVDYAMDKVITDQEKESMKRK-LTINE-TEVYRKLKNTVDKFLSMSGYSEVNLSKL Q59J90_AMBME Q59J90_AMBME RYIFDLEYTKEKSVSDVEKRLLKDA-ELD-GTDVVYKRLKGTVDRCLSSSGYSEVNLAKL DPOLA_XENLA DPOLA_XENLA RFIFDWDYALEKVVSEQERGHLKKK-LFQ-ESENQYKKLKSTVDQVLSRSGYSEVNLSKL B1WBE2_XENLA B1WBE2_XENLA RFILDWDYALEKVVSEQERGHLKKK-LFQ-ESENQYKKLKSTVDQVLSRSGYSEVNLSKL B7ZRF3_XENLA B7ZRF3_XENLA RFIFDWDYALEKVVSEQERGHLKKK-LFQ-ESENQYKKLKSTVDQVLSRSGYSEVNLSKL MATCH *:*:* : : :* . CONSENSUS R?IFD???A??K?????E?????????????????Y?K?K??????LS?S?YSEVNL?KL

Q6DRM6_DANRE Q6DRM6_DANRE ------------------ A6NMQ1_HUMAN A6NMQ1_HUMAN FAGCAVKS---------- DPOLA_HUMAN DPOLA_HUMAN FAGCAVKS---------- A2A4H0_MOUSE A2A4H0_MOUSE FANYAGKS---------- DPOLA_MOUSE DPOLA_MOUSE FANYAGKS---------- DPOLA_RAT DPOLA_RAT ------------------ Q59J88_IGUIG Q59J88_IGUIG FQTFNIVKSVGDPST--- Q59J86_CHICK Q59J86_CHICK FSVSMGRS-VGEPSSERQ Q59J87_CAICR Q59J87_CAICR FQTICTAKYVGDASNERQ Q59J89_TRASC Q59J89_TRASC FQTFSIVKSVGDPSNERQ Q59J90_AMBME Q59J90_AMBME FQGLSTMY---------- DPOLA_XENLA DPOLA_XENLA FQTLNTIK---------- B1WBE2_XENLA B1WBE2_XENLA FQTLNTIK---------- B7ZRF3_XENLA B7ZRF3_XENLA FQTLNTIK---------- MATCH CONSENSUS F?????????????????


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